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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

WAC Gene

protein-coding   GIFtS: 54
GCID: GC10P028861

WW Domain Containing Adaptor With Coiled-Coil

(Previous name: WW domain-containing adaptor with coiled coil)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
WW Domain Containing Adaptor With Coiled-Coil1 2     Wwp42
WW Domain-Containing Adaptor With Coiled Coil1     WW Domain-Containing Adapter Protein With Coiled-Coil2
BM-0162     KIAA18443
PRO17412     

External Ids:    HGNC: 173271   Entrez Gene: 513222   Ensembl: ENSG000000957877   OMIM: 6150495   UniProtKB: Q9BTA93   
ORGUL members:         
NONCODE14:n407062      

Export aliases for WAC gene to outside databases

Previous GC identifers: GC10P028557 GC10P028971 GC10P028825


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for WAC Gene:
The protein encoded by this gene contains a WW domain, which is a protein module found in a wide range of
signaling proteins. This domain mediates protein-protein interactions and binds proteins containing short linear
peptide motifs that are proline-rich or contain at least one proline. This gene product shares 94% sequence
identity with the WAC protein in mouse, however, its exact function is not known. Alternative splicing results in
multiple transcript variants. (provided by RefSeq, Dec 2008)

GeneCards Summary for WAC Gene: 
WAC (WW domain containing adaptor with coiled-coil) is a protein-coding gene, and is affiliated with the lncRNA class. Diseases associated with WAC include intrahepatic cholangiocarcinoma, and cholangiocarcinoma. GO annotations related to this gene include chromatin binding and RNA polymerase II core binding.

UniProtKB/Swiss-Prot: WAC_HUMAN, Q9BTA9
Function: Acts as a linker between gene transcription and histone H2B monoubiquitination at 'Lys-120'
(H2BK120ub1). Interacts with the RNA polymerase II transcriptional machinery via its WW domain and with
RNF20-RNF40 via its coiled coil region, thereby linking and regulating H2BK120ub1 and gene transcription.
Regulates the cell-cycle checkpoint activation in response to DNA damage. Positive regulator of amino acid
starvation-induced autophagy. May negatively regulate the ubiquitin proteasome pathway

Gene Wiki entry for WAC Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NT_008705.16  NC_018921.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the WAC gene promoter:
         MZF-1   c-Myb   CUTL1   Pax-4a   GATA-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidWAC promoter sequence
   Search SABiosciences Chromatin IP Primers for WAC

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WAC


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10p12.1|10p12.1-p11.2   Ensembl cytogenetic band:  10p12.1   HGNC cytogenetic band: 10p12.1

WAC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WAC gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P028861:  view genomic region     (about GC identifiers)

Start:
28,821,422 bp from pter      End:
28,909,928 bp from pter
Size:
88,507 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: WAC_HUMAN, Q9BTA9 (See protein sequence)
Recommended Name: WW domain-containing adapter protein with coiled-coil  
Size: 647 amino acids; 70724 Da
Subunit: Interacts (via coiled coil domain) with RNF20, RNF40 and UBE2A. Interacts (via WW domain) with RNA
polymerase II
Subcellular location: Nucleus speckle (By similarity). Nucleus. Note=In distinct nuclear speckles. Colocalizes
with pre-mRNA processing complexes (By similarity)
Sequence caution: Sequence=AAH04258.2; Type=Frameshift; Positions=641; Sequence=AAH10356.1; Type=Erroneous
initiation; Note=Translation N-terminally extended; Sequence=BAB47473.1; Type=Miscellaneous discrepancy;
Note=Probable cloning artifact; Sequence=CAH70767.1; Type=Erroneous gene model prediction; Sequence=CAI40921.1;
Type=Erroneous gene model prediction; Sequence=CAI40923.1; Type=Erroneous gene model prediction;
Secondary accessions: A8K2A9 C9JBT9 D3DRW5 D3DRW6 D3DRW7 Q53EN9 Q5JU75 Q5JU77 Q5VXK0 Q5VXK2
Q8TCK1 Q96DP3 Q96FW6 Q96JI3
Alternative splicing: 4 isoforms:  Q9BTA9-1   Q9BTA9-2   Q9BTA9-3   Q9BTA9-5   (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for WAC: NX_Q9BTA9

Explore proteomics data for WAC at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated on tyrosine residues (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9BTA9

  • WAC Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    WAC Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_057712.2  NP_567823.1  

    ENSEMBL proteins: 
     ENSP00000364816   ENSP00000434903   ENSP00000364797   ENSP00000311106   ENSP00000346986  
     ENSP00000404758   ENSP00000404125   ENSP00000400848   ENSP00000395008   ENSP00000415645  
     ENSP00000415727   ENSP00000399706  

    Human Recombinant Protein Products for WAC: 
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    OriGene Protein Over-expression Lysate for WAC
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    Novus Biologicals WAC Protein
    Novus Biologicals WAC Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for WAC 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus TAS--
    GO:0005681spliceosomal complex IEA--
    GO:0016607nuclear speck IEA--

    WAC for ontologies           About GeneDecksing



    WAC Antibody Products: 
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    Cloud-Clone Corp. CLIAs for WAC


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR001202 WW_dom

    Graphical View of Domain Structure for InterPro Entry Q9BTA9

    ProtoNet protein and cluster: Q9BTA9

    UniProtKB/Swiss-Prot: WAC_HUMAN, Q9BTA9
    Similarity: Contains 1 WW domain


    WAC for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: WAC_HUMAN, Q9BTA9
    Function: Acts as a linker between gene transcription and histone H2B monoubiquitination at 'Lys-120'
    (H2BK120ub1). Interacts with the RNA polymerase II transcriptional machinery via its WW domain and with
    RNF20-RNF40 via its coiled coil region, thereby linking and regulating H2BK120ub1 and gene transcription.
    Regulates the cell-cycle checkpoint activation in response to DNA damage. Positive regulator of amino acid
    starvation-induced autophagy. May negatively regulate the ubiquitin proteasome pathway

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000993RNA polymerase II core binding IDA--
    GO:0003682chromatin binding IDA--
    GO:0005515protein binding IPI--
         
    WAC for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for WAC:
     Decreased POU5F1-GFP protein e  Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for WAC 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for WAC

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for WAC 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for WAC 

    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidWAC 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WAC


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for WAC

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    5/12 Interacting proteins for WAC (Q9BTA92, 3 ENSP000003469864) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBQLN4Q9NRR52, 3, ENSP000003572924MINT-2873200 I2D: score=3 STRING: ENSP00000357292
    KRT15P190123, ENSP000002540434I2D: score=4 STRING: ENSP00000254043
    POLR2AP249283, ENSP000003149494I2D: score=1 STRING: ENSP00000314949
    RNF20Q5VTR23, ENSP000003737724I2D: score=1 STRING: ENSP00000373772
    RNF40O751503, ENSP000003256774I2D: score=1 STRING: ENSP00000325677
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000075cell cycle checkpoint ----
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006974response to DNA damage stimulus IMP--
    GO:0010390histone monoubiquitination IMP--
    GO:0016239positive regulation of macroautophagy IMP--

    WAC for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for WAC

    Search CenterWatch for drugs/clinical trials and news about WAC

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for WAC gene (3 alternative transcripts): 
    NM_016628.4  NM_100486.3  NM_100264.1  

    Unigene Cluster for WAC:

    WW domain containing adaptor with coiled-coil
    Hs.743224  [show with all ESTs]
    Unigene Representative Sequence: NR_024557
    18/20 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 20):
    ENST00000375664(uc001iud.3 uc001iue.3 uc001iuf.3 uc001iug.3 uc001iuh.3)
    ENST00000526722 ENST00000528491 ENST00000532233 ENST00000375646 ENST00000347934
    ENST00000354911 ENST00000420266 ENST00000424454(uc009xlb.3) ENST00000530865
    ENST00000442148 ENST00000448193 ENST00000414108 ENST00000439676 ENST00000345541
    ENST00000472862 ENST00000476046 ENST00000495268
    miRNA
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    8/83 QIAGEN miScript miRNA Assays for microRNAs that regulate WAC (see all 83):
    hsa-miR-3678-3p hsa-miR-300 hsa-miR-4272 hsa-miR-106a hsa-miR-578 hsa-miR-4275 hsa-miR-4274 hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmidWAC 3' UTR sequence
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WAC

    Additional mRNA sequence: 

    AB075491.1 AF208858.1 AK022049.1 AK055852.1 AK124104.1 AK223600.1 AK225846.1 AK290174.1 
    AK297460.1 AL713727.1 BC004258.1 BC010356.1 NR_024557.2 

    24/46 DOTS entries (see all 46):

    DT.100827239  DT.100773741  DT.99960629  DT.456367  DT.97798353  DT.91760286  DT.121282108  DT.91760302 
    DT.100827235  DT.121282280  DT.121282190  DT.100827241  DT.100827240  DT.121282247  DT.99991382  DT.100030624 
    DT.435098  DT.91760301  DT.95271222  DT.451988  DT.121282314  DT.105773  DT.87046079  DT.91668823 

    24/546 AceView cDNA sequences (see all 546):

    AI435324 BQ722382 AI149149 AA702742 BI030141 BE041552 AA337219 AW810673 
    AK055852 D58830 BF512534 H93776 BE881585 AU279958 BI819612 AA825970 
    AI582775 AA670037 CA417977 AW410294 CK821501 AL713727 AW184010 AI886698 

    GeneLoc Exon Structure

    5/17 Alternative Splicing Database (ASD) splice patterns (SP) for WAC (see all 17)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b ^ 11a · 11b · 11c ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16a · 16b ·
    SP1:        -     -           -     -     -                 -                       -                                                           -     -         
    SP2:                                                                                -     -     -     -                                         -     -         
    SP3:        -     -           -     -     -                 -                       -     -     -     -                                                         
    SP4:              -           -     -     -                 -                       -                                                                           
    SP5:                                                                                -     -     -     -                                         -     -         

    ExUns: 16c ^ 17 ^ 18a · 18b · 18c ^ 19a · 19b · 19c ^ 20a · 20b
    SP1:              -                       -     -               
    SP2:              -                       -     -               
    SP3:                                                            
    SP4:                                                            
    SP5:              -                                             


    ECgene alternative splicing isoforms for WAC

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    WAC expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTAAAACAAA
    WAC Expression
    About this image


    See WAC Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for WAC

    SOURCE GeneReport for Unigene cluster: Hs.743224
        SABiosciences Custom PCR Arrays for WAC
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for WAC gene from 6/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Wac1 , 5 WW domain containing adaptor with coiled-coil1, 5 92.83(n)1
    95.2(a)1
      18 (4.62 cM)5
    2251311  NM_153085.31  NP_694725.31 
     78688325 
    chicken
    (Gallus gallus)
    Aves WAC1 WW domain containing adaptor with coiled-coil 88.35(n)
    91.3(a)
      428414  XM_425975.3  XP_425975.3 
    lizard
    (Anolis carolinensis)
    Reptilia WAC6
    WW domain containing adaptor with coiled-coil
    89(a)
    1 ↔ 1
    6(13819205-13888072)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.178462 Xenopus laevis transcribed sequence with moderate similarity more 81.27(n)    CB983386.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufc13f042 wufc13f04 77.66(n)   323904  BC048888.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG89496
    --
    17(a)
    1 ↔ 1
    X(16962750-16971930)


    ENSEMBL Gene Tree for WAC (if available)
    TreeFam Gene Tree for WAC (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1861 SNPs in WAC are shown (see all 1861)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0363514
    A colorectal cancer sample4--see VAR_0363512 S L mis40--------
    rs10725231,2
    C,F,H--28537552(-) attccT/Cacact 1 -- us2k120Minor allele frequency- C:0.39NA NS EA WA 2712
    rs778643401,2
    C,F--28537553(+) GTGTGG/AGAATG 1 -- us2k11Minor allele frequency- A:0.07EA 120
    rs1444156201,2
    --28538500(+) TCTATC/TAGGTC 2 -- int10--------
    rs1884799461,2
    --28538534(+) TACCAA/CGTAAA 2 -- int10--------
    rs1149816351,2
    F--28538567(+) AGGGGG/ATTGTT 2 -- int11Minor allele frequency- A:0.03WA 118
    rs93314081,2
    C--28816152(+) TTTTT-/T/TT  
            
    CTGTT
    6 -- nc-transcript-variantut311NA 2
    rs1839678411,2
    --28823498(+) GAGGTC/TTTTGG 3 -- int10--------
    rs1381546311,2
    --28823747(+) ACTGTC/TTTCTG 3 -- int10--------
    rs1417811401,2
    --28823756(+) TGATAC/TGTAAA 3 -- int10--------

    HapMap Linkage Disequilibrium report for WAC (28821422 - 28909928 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for WAC:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2734606CNV Deletion23290073
    nsv894990CNV Loss21882294


    Human Gene Mutation Database (HGMD): WAC
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing WAC
    DNA2.0 Custom Variant and Variant Library Synthesis for WAC

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 615049    OMIM disorders: --

    3 diseases for WAC:    About MalaCards
    intrahepatic cholangiocarcinoma    cholangiocarcinoma    schizophrenia


    WAC for disorders           About GeneDecksing


    Export disorders for WAC gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for WAC gene, integrated from 9 sources (see all 36):
    (articles sorted by number of sources associating them with WAC)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genome-wide siRNA screen reveals amino acid starvation-induced autophagy requires SCOC and WAC. (PubMed id 22354037)1, 2 McKnight N.C.... Tooze S.A. (2012)
    2. WAC, a functional partner of RNF20/40, regulates histone H2B ubiquitination and gene transcription. (PubMed id 21329877)1, 2 Zhang F. and Yu X. (2011)
    3. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (2006)
    4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (2004)
    8. WAC, a novel WW domain-containing adapter with a coiled-coil region, is colocalized with splicing factor SC35. (PubMed id 11827461)1, 3 Xu G.M. and Arnaout M.A. (2002)
    9. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11347906)1, 2 Nagase T.... Ohara O. (2001)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 51322 HGNC: 17327 AceView: WAC Ensembl:ENSG00000095787 euGenes: HUgn51322
    ECgene: WAC H-InvDB: WAC

    (According to HUGE)
    About This Section
    HUGE: KIAA1844

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for WAC Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for WAC gene:
    Search GeneIP for patents involving WAC

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

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     Regulatory tfbs in WAC promoter
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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