Free for academic non-profit institutions. Other users need a Commercial license

Aliases for WAC Gene

Aliases for WAC Gene

  • WW Domain Containing Adaptor With Coiled-Coil 2 3 5
  • WW Domain-Containing Adaptor With Coiled Coil 2
  • KIAA1844 4
  • PRO1741 3
  • BM-016 3
  • DESSH 3
  • WWP4 3

External Ids for WAC Gene

Previous GeneCards Identifiers for WAC Gene

  • GC10P028971
  • GC10P028825
  • GC10P028861

Summaries for WAC Gene

Entrez Gene Summary for WAC Gene

  • The protein encoded by this gene contains a WW domain, which is a protein module found in a wide range of signaling proteins. This domain mediates protein-protein interactions and binds proteins containing short linear peptide motifs that are proline-rich or contain at least one proline. This gene product shares 94% sequence identity with the WAC protein in mouse, however, its exact function is not known. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2008]

GeneCards Summary for WAC Gene

WAC (WW Domain Containing Adaptor With Coiled-Coil) is a Protein Coding gene. GO annotations related to this gene include chromatin binding and RNA polymerase II core binding.

UniProtKB/Swiss-Prot for WAC Gene

  • Acts as a linker between gene transcription and histone H2B monoubiquitination at Lys-120 (H2BK120ub1). Interacts with the RNA polymerase II transcriptional machinery via its WW domain and with RNF20-RNF40 via its coiled coil region, thereby linking and regulating H2BK120ub1 and gene transcription. Regulates the cell-cycle checkpoint activation in response to DNA damage. Positive regulator of amino acid starvation-induced autophagy. May negatively regulate the ubiquitin proteasome pathway.

Gene Wiki entry for WAC Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WAC Gene

Genomics for WAC Gene

Regulatory Elements for WAC Gene

Enhancers for WAC Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around WAC on UCSC Golden Path with GeneCards custom track

Promoters for WAC Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around WAC on UCSC Golden Path with GeneCards custom track

Genomic Location for WAC Gene

Chromosome:
10
Start:
28,532,493 bp from pter
End:
28,623,112 bp from pter
Size:
90,620 bases
Orientation:
Plus strand

Genomic View for WAC Gene

Genes around WAC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WAC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WAC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WAC Gene

Proteins for WAC Gene

  • Protein details for WAC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BTA9-WAC_HUMAN
    Recommended name:
    WW domain-containing adapter protein with coiled-coil
    Protein Accession:
    Q9BTA9
    Secondary Accessions:
    • A8K2A9
    • C9JBT9
    • D3DRW5
    • D3DRW6
    • D3DRW7
    • Q53EN9
    • Q5JU75
    • Q5JU77
    • Q5VXK0
    • Q5VXK2
    • Q8TCK1
    • Q96DP3
    • Q96FW6
    • Q96JI3

    Protein attributes for WAC Gene

    Size:
    647 amino acids
    Molecular mass:
    70724 Da
    Quaternary structure:
    • Interacts (via coiled coil domain) with RNF20, RNF40 and UBE2A. Interacts (via WW domain) with RNA polymerase II.
    SequenceCaution:
    • Sequence=AAH04258.2; Type=Frameshift; Positions=641; Evidence={ECO:0000305}; Sequence=AAH10356.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB47473.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305}; Sequence=CAH70767.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI40921.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI40923.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for WAC Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for WAC Gene

Proteomics data for WAC Gene at MOPED

Post-translational modifications for WAC Gene

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for WAC

No data available for DME Specific Peptides for WAC Gene

Domains & Families for WAC Gene

Protein Domains for WAC Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9BTA9

UniProtKB/Swiss-Prot:

WAC_HUMAN :
  • Contains 1 WW domain.
Domain:
  • Contains 1 WW domain.
genes like me logo Genes that share domains with WAC: view

No data available for Gene Families for WAC Gene

Function for WAC Gene

Molecular function for WAC Gene

UniProtKB/Swiss-Prot Function:
Acts as a linker between gene transcription and histone H2B monoubiquitination at Lys-120 (H2BK120ub1). Interacts with the RNA polymerase II transcriptional machinery via its WW domain and with RNF20-RNF40 via its coiled coil region, thereby linking and regulating H2BK120ub1 and gene transcription. Regulates the cell-cycle checkpoint activation in response to DNA damage. Positive regulator of amino acid starvation-induced autophagy. May negatively regulate the ubiquitin proteasome pathway.

Gene Ontology (GO) - Molecular Function for WAC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding IDA 21329877
genes like me logo Genes that share ontologies with WAC: view
genes like me logo Genes that share phenotypes with WAC: view

Animal Model Products

miRNA for WAC Gene

miRTarBase miRNAs that target WAC

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for WAC Gene

Localization for WAC Gene

Subcellular locations from UniProtKB/Swiss-Prot for WAC Gene

Nucleus speckle. Nucleus. Note=In distinct nuclear speckles. Colocalizes with pre-mRNA processing complexes (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for WAC Gene COMPARTMENTS Subcellular localization image for WAC gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for WAC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with WAC: view

Pathways & Interactions for WAC Gene

SuperPathways for WAC Gene

No Data Available

Gene Ontology (GO) - Biological Process for WAC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006974 cellular response to DNA damage stimulus IMP 21329877
GO:0016239 positive regulation of macroautophagy IMP 22354037
GO:0045893 positive regulation of transcription, DNA-templated IMP 21329877
GO:0071894 histone H2B conserved C-terminal lysine ubiquitination IMP 21329877
genes like me logo Genes that share ontologies with WAC: view

No data available for Pathways by source and SIGNOR curated interactions for WAC Gene

Drugs & Compounds for WAC Gene

No Compound Related Data Available

Transcripts for WAC Gene

Unigene Clusters for WAC Gene

WW domain containing adaptor with coiled-coil:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for WAC Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b ^ 11a · 11b · 11c ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16a · 16b ·
SP1: - - - - - - - - -
SP2: - - - - - -
SP3: - - - - - - - - - -
SP4: - - - - - -
SP5: - - - - - -
SP6: - -
SP7: - - -
SP8: - - - - - - - - - - - - - - - -
SP9:
SP10:
SP11: - - - -
SP12: - -
SP13: - - -
SP14:
SP15:
SP16:
SP17:

ExUns: 16c ^ 17 ^ 18a · 18b · 18c ^ 19a · 19b · 19c ^ 20a · 20b
SP1: - - -
SP2: - - -
SP3:
SP4:
SP5: -
SP6: - - -
SP7: -
SP8:
SP9: - -
SP10: -
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:

Relevant External Links for WAC Gene

GeneLoc Exon Structure for
WAC
ECgene alternative splicing isoforms for
WAC

Expression for WAC Gene

mRNA expression in normal human tissues for WAC Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for WAC Gene

This gene is overexpressed in Heart (31.6), CD8 Tcells (8.5), and Liver, secretome (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for WAC Gene



SOURCE GeneReport for Unigene cluster for WAC Gene Hs.743224

genes like me logo Genes that share expression patterns with WAC: view

Protein tissue co-expression partners for WAC Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for WAC Gene

Orthologs for WAC Gene

This gene was present in the common ancestor of animals.

Orthologs for WAC Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia WAC 35
  • 94.96 (n)
  • 97.04 (a)
WAC 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia WAC 35
  • 95.63 (n)
  • 96.87 (a)
-- 36
  • 96 (a)
OneToMany
-- 36
  • 97 (a)
OneToMany
-- 36
  • 91 (a)
OneToMany
-- 36
  • 96 (a)
OneToMany
-- 36
  • 89 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Wac 35
  • 92.83 (n)
  • 95.2 (a)
Wac 16
Wac 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia WAC 35
  • 99.74 (n)
  • 99.54 (a)
WAC 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1562407 35
  • 92.62 (n)
  • 94.58 (a)
oppossum
(Monodelphis domestica)
Mammalia WAC 36
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia WAC 36
  • 94 (a)
OneToOne
chicken
(Gallus gallus)
Aves WAC 35
  • 87.78 (n)
  • 90.67 (a)
WAC 36
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia WAC 36
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.2721 35
wac 35
  • 80.78 (n)
  • 84.19 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.17846 35
zebrafish
(Danio rerio)
Actinopterygii waca 35
  • 66.67 (n)
  • 72.91 (a)
wufc13f04 35
WAC (3 of 3) 36
  • 55 (a)
OneToMany
waca 36
  • 71 (a)
OneToMany
wacb 36
  • 61 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG8949 36
  • 18 (a)
OneToOne
Species with no ortholog for WAC:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for WAC Gene

ENSEMBL:
Gene Tree for WAC (if available)
TreeFam:
Gene Tree for WAC (if available)

Paralogs for WAC Gene

No data available for Paralogs for WAC Gene

Variants for WAC Gene

Sequence variations from dbSNP and Humsavar for WAC Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs11595926 - 28,595,848(+) AGTAG(A/T)TCTAC intron-variant, nc-transcript-variant, reference, missense
rs7127 - 28,616,207(-) AGAAG(A/T)ATGAT nc-transcript-variant, reference, missense
VAR_036351 A colorectal cancer sample
rs2232791 - 28,608,191(+) AATCT(A/G)CATCA nc-transcript-variant, reference, missense
rs167967 -- 28,622,050(+) TTTTG(C/T)ATTTT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for WAC Gene

Variant ID Type Subtype PubMed ID
esv2734606 CNV Deletion 23290073
nsv894990 CNV Loss 21882294

Variation tolerance for WAC Gene

Residual Variation Intolerance Score: 22.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.75; 66.50% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for WAC Gene

HapMap Linkage Disequilibrium report
WAC
Human Gene Mutation Database (HGMD)
WAC

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WAC Gene

Disorders for WAC Gene

Relevant External Links for WAC

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
WAC

No disorders were found for WAC Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WAC Gene

Publications for WAC Gene

  1. Genome-wide siRNA screen reveals amino acid starvation-induced autophagy requires SCOC and WAC. (PMID: 22354037) McKnight N.C. … Tooze S.A. (EMBO J. 2012) 3 4 67
  2. WAC, a novel WW domain-containing adapter with a coiled-coil region, is colocalized with splicing factor SC35. (PMID: 11827461) Xu G.M. … Arnaout M.A. (Genomics 2002) 2 3
  3. KCMF1 (potassium channel modulatory factor 1) Links RAD6 to UBR4 (ubiquitin N-recognin domain-containing E3 ligase 4) and lysosome-mediated degradation. (PMID: 25582440) Hong J.H. … Raught B. (Mol. Cell Proteomics 2015) 3
  4. Control of a neuronal morphology program by an RNA-binding zinc finger protein, Unkempt. (PMID: 25737280) Murn J. … Shi Y. (Genes Dev. 2015) 3
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3

Products for WAC Gene

Sources for WAC Gene

Content