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WAC Gene

protein-coding   GIFtS: 52
GCID: GC10P028861

WW Domain Containing Adaptor With Coiled-Coil

(Previous name: WW domain-containing adaptor with coiled coil)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
WW Domain Containing Adaptor With Coiled-Coil1 2     PRO17412
KIAA18443 5     Wwp42
WW Domain-Containing Adaptor With Coiled Coil1     WW Domain-Containing Adapter Protein With Coiled-Coil2
BM-0162     

External Ids:    HGNC: 173271   Entrez Gene: 513222   Ensembl: ENSG000000957877   OMIM: 6150495   UniProtKB: Q9BTA93   

Export aliases for WAC gene to outside databases

Previous GC identifers: GC10P028557 GC10P028971 GC10P028825


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for WAC Gene:
The protein encoded by this gene contains a WW domain, which is a protein module found in a wide range of
signaling proteins. This domain mediates protein-protein interactions and binds proteins containing short linear
peptide motifs that are proline-rich or contain at least one proline. This gene product shares 94% sequence
identity with the WAC protein in mouse, however, its exact function is not known. Alternative splicing results in
multiple transcript variants. (provided by RefSeq, Dec 2008)

GeneCards Summary for WAC Gene:
WAC (WW domain containing adaptor with coiled-coil) is a protein-coding gene. GO annotations related to this gene include chromatin binding and RNA polymerase II core binding.

UniProtKB/Swiss-Prot: WAC_HUMAN, Q9BTA9
Function: Acts as a linker between gene transcription and histone H2B monoubiquitination at 'Lys-120'
(H2BK120ub1). Interacts with the RNA polymerase II transcriptional machinery via its WW domain and with
RNF20-RNF40 via its coiled coil region, thereby linking and regulating H2BK120ub1 and gene transcription.
Regulates the cell-cycle checkpoint activation in response to DNA damage. Positive regulator of amino acid
starvation-induced autophagy. May negatively regulate the ubiquitin proteasome pathway

Gene Wiki entry for WAC Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the WAC gene promoter:
         MZF-1   c-Myb   CUTL1   Pax-4a   GATA-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidWAC promoter sequence
   Search Chromatin IP Primers for WAC

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat WAC


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10p12.1|10p12.1-p11.2   Ensembl cytogenetic band:  10p12.1   HGNC cytogenetic band: 10p12.1

WAC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WAC gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P028861:  view genomic region     (about GC identifiers)

Start:
28,821,422 bp from pter      End:
28,912,041 bp from pter
Size:
90,620 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: WAC_HUMAN, Q9BTA9 (See protein sequence)
Recommended Name: WW domain-containing adapter protein with coiled-coil  
Size: 647 amino acids; 70724 Da
Subunit: Interacts (via coiled coil domain) with RNF20, RNF40 and UBE2A. Interacts (via WW domain) with RNA
polymerase II
Sequence caution: Sequence=AAH04258.2; Type=Frameshift; Positions=641; Sequence=AAH10356.1; Type=Erroneous
initiation; Note=Translation N-terminally extended; Sequence=BAB47473.1; Type=Miscellaneous discrepancy;
Note=Probable cloning artifact; Sequence=CAH70767.1; Type=Erroneous gene model prediction; Sequence=CAI40921.1;
Type=Erroneous gene model prediction; Sequence=CAI40923.1; Type=Erroneous gene model prediction;
Secondary accessions: A8K2A9 C9JBT9 D3DRW5 D3DRW6 D3DRW7 Q53EN9 Q5JU75 Q5JU77 Q5VXK0 Q5VXK2
Q8TCK1 Q96DP3 Q96FW6 Q96JI3
Alternative splicing: 4 isoforms:  Q9BTA9-1   Q9BTA9-2   Q9BTA9-3   Q9BTA9-5   (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for WAC: NX_Q9BTA9

Explore proteomics data for WAC at MOPED

Post-translational modifications: 

  • Phosphorylated on tyrosine residues (By similarity)1
  • Ubiquitination2 at Lys466, Lys486
  • Modification sites at PhosphoSitePlus

  • See WAC Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_057712.2  NP_567823.1  

    ENSEMBL proteins: 
     ENSP00000364816   ENSP00000434903   ENSP00000364797   ENSP00000311106   ENSP00000346986  
     ENSP00000404758   ENSP00000404125   ENSP00000400848   ENSP00000395008   ENSP00000415645  
     ENSP00000415727   ENSP00000399706  

    WAC Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for WAC
    OriGene Custom MassSpec
    OriGene Custom Protein Services for WAC
    GenScript Custom Purified and Recombinant Proteins Services for WAC
    Novus Biologicals WAC Protein
    Novus Biologicals WAC Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for WAC

     
    Search eBioscience for Proteins for WAC 

     
    antibodies-online proteins for WAC (3 products) 

     
    antibodies-online peptides for WAC

    WAC Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of WAC
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    antibodies-online antibodies for WAC (11 products) 

    WAC Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for WAC
    Cloud-Clone Corp. CLIAs for WAC
    Search eBioscience for ELISAs for WAC 
    antibodies-online kits for WAC (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR001202 WW_dom

    Graphical View of Domain Structure for InterPro Entry Q9BTA9

    ProtoNet protein and cluster: Q9BTA9

    UniProtKB/Swiss-Prot: WAC_HUMAN, Q9BTA9
    Similarity: Contains 1 WW domain


    Find genes that share domains with WAC           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: WAC_HUMAN, Q9BTA9
    Function: Acts as a linker between gene transcription and histone H2B monoubiquitination at 'Lys-120'
    (H2BK120ub1). Interacts with the RNA polymerase II transcriptional machinery via its WW domain and with
    RNF20-RNF40 via its coiled coil region, thereby linking and regulating H2BK120ub1 and gene transcription.
    Regulates the cell-cycle checkpoint activation in response to DNA damage. Positive regulator of amino acid
    starvation-induced autophagy. May negatively regulate the ubiquitin proteasome pathway

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000993RNA polymerase II core binding IDA--
    GO:0003682chromatin binding IDA--
    GO:0005515protein binding IPI17500595
         
    Find genes that share ontologies with WAC           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for WAC:
     Decreased POU5F1-GFP protein e  Synthetic lethal with Ras 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for WAC

    miRNA
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    miRTarBase miRNAs that target WAC:
    hsa-mir-17-5p (MIRT051026), hsa-mir-93-5p (MIRT048913), hsa-mir-20a-5p (MIRT050624), hsa-mir-15b-5p (MIRT046410), hsa-mir-18a-5p (MIRT050717), hsa-mir-484 (MIRT042156), hsa-mir-18b-5p (MIRT042412)

    Block miRNA regulation of human, mouse, rat WAC using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate WAC (see all 83):
    hsa-miR-3678-3p hsa-miR-300 hsa-miR-4272 hsa-miR-106a hsa-miR-578 hsa-miR-4275 hsa-miR-4274 hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmidWAC 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat WAC

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    OriGene clones in human, mouse for WAC (see all 13)
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    GenScript: all cDNA clones in your preferred vector (see all 2): WAC (NM_016628)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for WAC
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WAC

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WAC


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    WAC_HUMAN, Q9BTA9: Nucleus speckle (By similarity). Nucleus. Note=In distinct nuclear speckles. Colocalizes
    with pre-mRNA processing complexes (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus TAS--
    GO:0005681spliceosomal complex IEA--
    GO:0005730NOT nucleolus IDA--
    GO:0016607nuclear speck IEA--

    Find genes that share ontologies with WAC           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for WAC
    Interactions:

        Search GeneGlobe Interaction Network for WAC

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for WAC (Q9BTA92, 3 ENSP000003469864) via UniProtKB, MINT, STRING, and/or I2D (see all 58)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBQLN4Q9NRR52, 3, ENSP000003572924MINT-2873200 I2D: score=3 STRING: ENSP00000357292
    KRT15P190123, ENSP000002540434I2D: score=4 STRING: ENSP00000254043
    POLR2AP249283, ENSP000003149494I2D: score=1 STRING: ENSP00000314949
    RNF20Q5VTR23, ENSP000003737724I2D: score=1 STRING: ENSP00000373772
    RNF40O751503, ENSP000003256774I2D: score=1 STRING: ENSP00000325677
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006974cellular response to DNA damage stimulus IMP--
    GO:0010390histone monoubiquitination IMP--
    GO:0016239positive regulation of macroautophagy IMP--
    GO:0032435negative regulation of proteasomal ubiquitin-dependent protein catabolic process IMP--

    Find genes that share ontologies with WAC           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for WAC



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for WAC gene (3 alternative transcripts): 
    NM_016628.4  NM_100486.3  NM_100264.1  

    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 20):
    ENST00000375664(uc001iud.3 uc001iue.3 uc001iuf.3 uc001iug.3 uc001iuh.3)
    ENST00000526722 ENST00000528491 ENST00000532233 ENST00000375646 ENST00000347934
    ENST00000354911 ENST00000420266 ENST00000424454(uc009xlb.3) ENST00000530865
    ENST00000442148 ENST00000448193 ENST00000414108 ENST00000439676 ENST00000345541
    ENST00000472862 ENST00000476046 ENST00000495268
    miRNA
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    Block miRNA regulation of human, mouse, rat WAC using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate WAC (see all 83):
    hsa-miR-3678-3p hsa-miR-300 hsa-miR-4272 hsa-miR-106a hsa-miR-578 hsa-miR-4275 hsa-miR-4274 hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmidWAC 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat WAC
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    OriGene ORF clones in mouse, rat for WAC
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): WAC (NM_016628)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for WAC
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WAC
    Primer
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    OriGene qPCR primer pairs and template standards for WAC
    OriGene qSTAR qPCR primer pairs in human, mouse for WAC
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat WAC
      QuantiTect SYBR Green Assays in human, mouse, rat WAC
      QuantiFast Probe-based Assays in human, mouse, rat WAC

    Selected AceView cDNA sequences (see all 546):

    AW410293 D58830 AA565636 N28219 AI650315 AI356179 BM725015 BE385012 
    AI582764 AI472639 CA424345 CB069736 AV715931 CA429979 AA702742 AA337539 
    BX499819 AA058391 AA334893 AA375507 AI468978 AK055852 BU618476 BE881585 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for WAC (see all 17)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b ^ 11a · 11b · 11c ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16a · 16b ·
    SP1:        -     -           -     -     -                 -                       -                                                           -     -         
    SP2:                                                                                -     -     -     -                                         -     -         
    SP3:        -     -           -     -     -                 -                       -     -     -     -                                                         
    SP4:              -           -     -     -                 -                       -                                                                           
    SP5:                                                                                -     -     -     -                                         -     -         

    ExUns: 16c ^ 17 ^ 18a · 18b · 18c ^ 19a · 19b · 19c ^ 20a · 20b
    SP1:              -                       -     -               
    SP2:              -                       -     -               
    SP3:                                                            
    SP4:                                                            
    SP5:              -                                             


    ECgene alternative splicing isoforms for WAC

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    WAC expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTAAAACAAA
    WAC Expression
    About this image


    WAC expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 16) fully expand
     
     Brain (Nervous System)
             Cerebral Cortex
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Colon (Gastrointestinal Tract)
     
     Uterus (Reproductive System)
     
     Thyroid (Endocrine System)
    WAC Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    WAC Protein Expression
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    QuantiFast Probe-based Assays in human, mouse, rat WAC
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WAC

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for WAC gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Wac1 , 5 WW domain containing adaptor with coiled-coil1, 5 92.83(n)1
    95.2(a)1
      18 (4.62 cM)5
    2251311  NM_153085.41  NP_694725.31 
     78688325 
    chicken
    (Gallus gallus)
    Aves WAC1 WW domain containing adaptor with coiled-coil 87.78(n)
    90.67(a)
      428414  XM_004939206.1  XP_004939263.1 
    lizard
    (Anolis carolinensis)
    Reptilia WAC6
    WW domain containing adaptor with coiled-coil
    89(a)
    1 ↔ 1
    6(13819205-13888072)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.178462 Xenopus laevis transcribed sequence with moderate similarity more 81.27(n)    CB983386.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufc13f042 wufc13f04 77.66(n)   323904  BC048888.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG89496
    --
    18(a)
    1 ↔ 1
    X(16962750-16971930)


    ENSEMBL Gene Tree for WAC (if available)
    TreeFam Gene Tree for WAC (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for WAC (see all 1861)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0363514
    A colorectal cancer sample4--see VAR_0363512 S L mis40--------
    rs10725231,2
    C,F,H--28537552(-) attccT/Cacact 1 -- us2k120Minor allele frequency- C:0.39NA NS EA WA 2712
    rs778643401,2
    C,F--28537553(+) GTGTGG/AGAATG 1 -- us2k11Minor allele frequency- A:0.07EA 120
    rs1444156201,2
    --28538500(+) TCTATC/TAGGTC 2 -- int10--------
    rs1884799461,2
    --28538534(+) TACCAA/CGTAAA 2 -- int10--------
    rs1149816351,2
    F--28538567(+) AGGGGG/ATTGTT 2 -- int11Minor allele frequency- A:0.03WA 118
    rs93314081,2
    C--28816152(+) TTTTT-/T/TT  
            
    CTGTT
    6 -- nc-transcript-variantut311NA 2
    rs1839678411,2
    --28823498(+) GAGGTC/TTTTGG 3 -- int10--------
    rs1381546311,2
    --28823747(+) ACTGTC/TTTCTG 3 -- int10--------
    rs1417811401,2
    --28823756(+) TGATAC/TGTAAA 3 -- int10--------

    HapMap Linkage Disequilibrium report for WAC (28821422 - 28912041 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for WAC:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2734606CNV Deletion23290073
    nsv894990CNV Loss21882294

    Human Gene Mutation Database (HGMD): WAC
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing WAC
    DNA2.0 Custom Variant and Variant Library Synthesis for WAC

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 615049    OMIM disorders: --


    Find genes that share disorders with WAC           About GenesLikeMe


    Export disorders for WAC gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for WAC gene, integrated from 10 sources (see all 38):
    (articles sorted by number of sources associating them with WAC)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genome-wide siRNA screen reveals amino acid starvation-induced autophagy requires SCOC and WAC. (PubMed id 22354037)1, 2 McKnight N.C.... Tooze S.A. (EMBO J. 2012)
    2. WAC, a functional partner of RNF20/40, regulates histone H2B ubiquitination and gene transcription. (PubMed id 21329877)1, 2 Zhang F. and Yu X. (Mol. Cell 2011)
    3. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (Nat. Biotechnol. 2006)
    4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (Nature 2004)
    8. WAC, a novel WW domain-containing adapter with a coiled-coil region, is colocalized with splicing factor SC35. (PubMed id 11827461)1, 3 Xu G.M. and Arnaout M.A. (Genomics 2002)
    9. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11347906)1, 2 Nagase T.... Ohara O. (DNA Res. 2001)
    10. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 51322 HGNC: 17327 AceView: WAC Ensembl:ENSG00000095787 euGenes: HUgn51322
    ECgene: WAC H-InvDB: WAC

    (According to HUGE)
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    HUGE: KIAA1844

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for WAC Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for WAC gene:
    Search GeneIP for patents involving WAC

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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