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Aliases & Descriptions for WAC
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases 1110067P07Rik 2 BM-016 1 , 2 FLJ31290 1 KIAA1844 3 MGC10753 1 , 2 OTTHUMP00000019382 2 OTTHUMP00000019383 2 OTTHUMP00000046067 2 PRO1741 1 , 2 Wwp4 1 , 2 bA48B24 2 bA48B24.1 2
Descriptions WW domain containing adaptor with coiled-coil 2 WW domain-containing adapter with a coiled-coil region 2 WW domain-containing adaptor with coiled coil 1 , 2
Search outside databases for aliases for WAC genePrevious GC identifers: GC10P028557 GC10P028971 GC10P028825
Summaries for WAC (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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EntrezGene summary for WAC : The protein encoded by this gene contains a WW domain, which is a protein module found in a widerange of signaling proteins. This domain mediates protein-protein interactions and binds proteinscontaining short linear peptide motifs that are proline-rich or contain at least one proline. Thisgene product shares 94% sequence identity with the WAC protein in mouse, however, its exactfunction is not known. Alternative splicing results in multiple transcript variants. [provided byRefSeq] Gene Wiki entry for WAC
Genomic Location for WAC
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
Genomic Views according to
UCSC and
Ensembl ,
Transcription factor binding sites according to
SABiosciences )About This Section
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Genomic View : UCSC Golden Path with GeneCards custom track Transcription factor binding sites upstream to the WAC gene Ensembl cytogenetic band: 10p11.23 HGNC cytogenetic band: 10p12.1 WAC Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 10 GeneLoc Exon Structure
GeneLoc location for GC10P028861:
(about GC identifiers )
Start:
28,861,706 bp from pter
End:
28,949,703 bp from pter
Size:
87,998 bases
Orientation:
plus strand
RefSeq DNA sequence: NC_000010.9 NT_008705.15 Proteins for WAC
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: WAC_HUMAN, Q9BTA9 (See
protein sequence )Recommended Name: WW domain-containing adapter protein with coiled-coil Size : 647 amino acids; 70724 Da
Subcellular location : Nucleus speckle (By similarity). Note=In distinct nuclear speckles.Colocalizes with pre-mRNA processing complexes (By similarity)
Sequence caution : Sequence=AAH04258.2; Type=Frameshift; Positions=641;
Secondary accessions : Q53EN9 Q5VXK0 Q5VXK2 Q8TCK1 Q96DP3 Q96FW6 Q96JI3Alternative splicing : 5 isoforms : Q9BTA9-1 Q9BTA9-2 Q9BTA9-3 Q9BTA9-4 Q9BTA9-5
Post-translational modifications:
Phosphorylated on tyrosine residues (By similarity)1
View phosphorylation sites using PhosphoSite 2
REFSEQ proteins (3 alternative transcripts):
NP_057712.2 NP_567822.1 NP_567823.1 ENSEMBL proteins: ENSP00000364797 ENSP00000304009 ENSP00000341462 ENSP00000364816 ENSP00000346986 ENSP00000311106 Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 2 Gene Ontology (GO) cellular component terms (links to tree view) :
About this table Antibodies for WAC: Assays for WAC:
Protein
Domains/ Families for WAC(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry Q9BTA9 ProtoNet protein and cluster: Q9BTA9
UniProtKB/Swiss-Prot: WAC_HUMAN, Q9BTA9 Similarity : Contains 1 WW domain
Gene Function for WAC
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
shRNA from
OriGene ,
Sigma-Aldrich , RNAi from
Sigma-Aldrich ,
RNAi Products ,
Clones , and
Q-PCR Products
from Invitrogen ,
Millipore ,
OriGene , and/or
Abnova ,
siRNAs from
Applied Biosystems ,
SYBR primers from OriGene ,
Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4 ): NR_024557 Applied Biosystems Silencer ® siRNAs for WAC Sigma-Aldrich siRNA for WAC Sigma-Aldrich shRNA for WAC Explore Sigma-Aldrich super-pooled esiRNAs                OriGene GFP tagged cDNA clones in CMV expression vector (see all 3 ): NM_016628                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 3 ): NM_016628                                  untagged cDNA clones in CMV expression vector (see all 4 ): NM_016628  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_016628 1 Gene Ontology (GO) molecular function term (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0005515 protein binding
IEA --
About this table
Pathways & Interactions for WAC
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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1 Interacting protein for WAC (ENSP00000304009 3 ) via UniProtKB, MINT, and/or STRING About this table
Drugs & Compounds for WAC (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
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Browse Tocris compounds for WAC
Transcripts for WAC(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from Invitrogen ,
Millipore , and/or
Abnova ,
siRNAs from Applied Biosystems ,
Sigma-Aldrich ,
shRNA from
Sigma-Aldrich ,
OriGene ,
Tagged/untagged cDNA clones from
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4 ): NR_024557 Sigma-Aldrich siRNA for WAC Sigma-Aldrich shRNA for WAC Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_016628 NM_100486
REFSEQ mRNAs for WAC gene (3 alternative transcripts): NM_016628.3 NM_100264.1 NM_100486.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_016628 NM_100486
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 3 ): NM_016628                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 3 ): NM_016628                                  untagged cDNA clones in CMV expression vector (see all 4 ): NM_016628  
Additional cDNA sequence: AB075491.1 AF208858.1 AK022049.1 AK055852.1 AK091453.1 AK124104.1 AK223600.1 AK225846.1 AK290174.1 AK297460.1 AL713727.1 BC004258.1 BC010356.1
24/45 DOTS entries (see all 45
): DT.100827239 DT.100773741 DT.99960629 DT.456367 DT.97798353 DT.91760286 DT.121282108 DT.91760302 DT.100827235 DT.100827241 DT.121282280 DT.121282190 DT.100827240 DT.121282247 DT.99991382 DT.100030624 DT.117023 DT.435098 DT.87046079 DT.95271222 DT.121282314 DT.451988 DT.91674797 DT.91668823
24/546 AceView cDNA sequences (see all 546
):AI654518 BI029354 AA677400 BI819612 AA565636 AI299529 CN480377 AW515944 BM717528 BX499819 BE467758 AI422679 BQ000607 AI613288 CD671378 AA668936 BF196961 BM353589 CA449480 BQ025869 AI934351 AI753571 AA999970 AA812031
highest scoring ESTs for WAC :N32178 AA012957 AA018507 AA019945 AA019954 AA031552 AA036642 AA059035 AA132911 AA164243
Unigene Cluster for WAC: WW domain containing adaptor with coiled-coil Hs.714700 [show with all ESTs ] Unigene Representative Sequence: NM_016628 GeneLoc Exon Structure 5/17 Alternative Splicing Database (ASD) splice patterns (SP) for WAC (see all 17
) ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b ^ 11a · 11b · 11c ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16a · 16b · SP1 :   -   -     -   -   -       -         -                     -   -     SP2 :                           -   -   -   -               -   -     SP3 :   -   -     -   -   -       -         -   -   -   -                     SP4 :     -     -   -   -       -         -                           SP5 :                           -   -   -   -               -   -    
ExUns: 16c ^ 17 ^ 18a · 18b · 18c ^ 19a · 19b · 19c ^ 20a · 20b SP1 :     -         -   -       SP2 :     -         -   -       SP3 :                     SP4 :                     SP5 :     -                
About this scheme ECgene alternative splicing isoforms for WAC 6 Ensembl transcripts including schematic representations : ENST00000375646
ENST00000345541
ENST00000338396
ENST00000375664
ENST00000354911
ENST00000347934
Expression for WAC
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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WAC expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for WAC 1 / 2 / 3
13 probe-sets matching WAC gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: TTAAAACAAASOURCE GeneReport for Unigene cluster: Hs.714700
Orthologs for WAC
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for WAC gene from 5/8 species (see all 8
)
About this table Species with no ortholog for WAC ENSEMBL Gene Tree for WAC Paralogs for WAC (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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--
SNPs/Variants for WAC (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for WAC (up to first 250kb)
Disorders & Mutations for WAC
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
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Medical News for WAC (Possibly Related Articles in
Doctor's Guide )
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Publications for WAC (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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10/19 PubMed articles for WAC gene (see all 19
): A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243) 3, 4 Beausoleil S.A.... Gygi S.P. (2006) Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983) 3, 4 Olsen J.V....Mann M. (2006) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 3, 4 Gerhard D.S....Malek J. (2004) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 3, 4 Ota T....Sugano S. (2004) The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054) 3, 4 Deloukas P.... Rogers J. (2004) WAC, a novel WW domain-containing adapter with a coiled-coil region, is colocalized with splicing factor SC35. (PubMed id 11827461) 2, 3 Xu G.M. and Arnaout M.A. (2002) Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11347906) 3, 4 Nagase T....Ohara O. (2001) Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis. (PubMed id 18220336) 4 Cantin G.T....Yates J.R. III (2008) A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648) 4 Dephoure N.... Gygi S.P. (2008) The full-ORF clone resource of the German cDNA Consortium. (PubMed id 17974005) 4 Bechtel S....Schupp I. (2007)
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Genome Databases showing WAC
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
and/or
H-InvDB )
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Other Databases showing WAC
(According to HUGE )
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Specialized Databases showing WAC (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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-- Services for WAC (Reagents available from Applied Biosystems , Antibodies and assays by Cell
Signaling Technology , Abcam , Novus Biologicals ,Sigma-Aldrich , R&D Systems , Millipore , Abnova , and/or Invitrogen , Clones available from OriGene ,and/or Invitrogen , Drugs and/or compounds by Sigma-Aldrich , Enzo Life Sciences , and/or Tocris Bioscience )About This Section
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