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WAC Gene

protein-coding   GIFtS: 49

GC10P028861
WW domain containing adaptor with coiled-coil
(Previous name: WW domain-containing adaptor with coiled coil )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases
1110067P07Rik 2
BM-016 1, 2
FLJ31290 1
KIAA1844 3
MGC10753 1, 2
OTTHUMP00000019382 2
OTTHUMP00000019383 2
OTTHUMP00000046067 2
PRO1741 1, 2
Wwp4 1, 2
bA48B24 2
bA48B24.1 2
Descriptions
WW domain containing adaptor with coiled-coil 2
WW domain-containing adapter with a coiled-coil region 2
WW domain-containing adaptor with coiled coil 1, 2
External Ids
HGNC: 173271
Entrez Gene: 513222
UniProtKB: Q9BTA93
Ensembl: ENSG000000957877
Search outside databases for aliases for WAC gene

Previous GC identifers: GC10P028557 GC10P028971 GC10P028825

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for WAC:
The protein encoded by this gene contains a WW domain, which is a protein module found in a wide
range of signaling proteins. This domain mediates protein-protein interactions and binds proteins
containing short linear peptide motifs that are proline-rich or contain at least one proline. This
gene product shares 94% sequence identity with the WAC protein in mouse, however, its exact
function is not known. Alternative splicing results in multiple transcript variants. [provided by
RefSeq]

Gene Wiki entry for WAC
(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the WAC gene  

Ensembl cytogenetic band:  10p11.23   HGNC cytogenetic band: 10p12.1

WAC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P028861:     (about GC identifiers)

Start:
28,861,706 bp from pter
End:
28,949,703 bp from pter
Size:
87,998 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000010.9  NT_008705.15  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: WAC_HUMAN, Q9BTA9 (See protein sequence)
Recommended Name: WW domain-containing adapter protein with coiled-coil  
Size: 647 amino acids; 70724 Da
Subcellular location: Nucleus speckle (By similarity). Note=In distinct nuclear speckles.
Colocalizes with pre-mRNA processing complexes (By similarity)
Sequence caution: Sequence=AAH04258.2; Type=Frameshift; Positions=641;
Secondary accessions: Q53EN9 Q5VXK0 Q5VXK2 Q8TCK1 Q96DP3 Q96FW6 Q96JI3
Alternative splicing: 5 isoforms:  Q9BTA9-1   Q9BTA9-2   Q9BTA9-3   Q9BTA9-4   Q9BTA9-5   

Post-translational modifications:

  • Phosphorylated on tyrosine residues (By similarity)1
  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins (3 alternative transcripts): 
    NP_057712.2  NP_567822.1  NP_567823.1  


    ENSEMBL proteins: 
    ENSP00000364797 ENSP00000304009 ENSP00000341462 ENSP00000364816 ENSP00000346986 ENSP00000311106 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse Abcam for Recombinant Proteins
    Human Recombinant Proteins from Abnova (WAC)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    2 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634 nucleus IEA--
    GO:0016607 nuclear speck IEA--
    About this table

    Antibodies for WAC: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse Antibodies at Sigma-Aldrich
    Browse R&D Systems for Antibodies
    Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
    Browse Abnova for Monoclonal and Polyclonal Antibodies
    Search Novus for antibodies for WAC

    Assays for WAC: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    1 InterPro domain/family:
     IPR001202 WW_Rsp5_WWP


       GeneDecks  WAC for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry Q9BTA9

    ProtoNet protein and cluster: Q9BTA9

    UniProtKB/Swiss-Prot: WAC_HUMAN, Q9BTA9
    Similarity: Contains 1 WW domain

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (WAC)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): NR_024557

                  Applied Biosystems Silencer® siRNAs for WAC

                  Sigma-Aldrich siRNA for WAC  
                         Sigma-Aldrich shRNA for WAC  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for WAC
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_016628
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_016628
                                     untagged cDNA clones in CMV expression vector (see all 4): NM_016628 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_016628

    1 Gene Ontology (GO) molecular function term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515 protein binding IEA--
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section



    1 Interacting protein for WAC (ENSP000003040093) via UniProtKB, MINT, and/or STRING
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BAZ1AENSP000003718593STRING (score=.818)
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for WAC

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (WAC)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): NR_024557

                  Sigma-Aldrich siRNA for WAC  
                         Sigma-Aldrich shRNA for WAC  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_016628  NM_100486  

    REFSEQ mRNAs for WAC gene (3 alternative transcripts): 

    NM_016628.3   NM_100264.1   NM_100486.2   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_016628  NM_100486  

                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_016628
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_016628
                                     untagged cDNA clones in CMV expression vector (see all 4): NM_016628 

    Additional cDNA sequence: 

    AB075491.1 AF208858.1 AK022049.1 AK055852.1 AK091453.1 AK124104.1 AK223600.1 AK225846.1 
    AK290174.1 AK297460.1 AL713727.1 BC004258.1 BC010356.1 

    24/45 DOTS entries (see all 45 ):

    DT.100827239  DT.100773741  DT.99960629  DT.456367  DT.97798353  DT.91760286  DT.121282108  DT.91760302 
    DT.100827235  DT.100827241  DT.121282280  DT.121282190  DT.100827240  DT.121282247  DT.99991382  DT.100030624 
    DT.117023  DT.435098  DT.87046079  DT.95271222  DT.121282314  DT.451988  DT.91674797  DT.91668823 

    24/546 AceView cDNA sequences (see all 546 ):

    AI654518 BI029354 AA677400 BI819612 AA565636 AI299529 CN480377 AW515944 
    BM717528 BX499819 BE467758 AI422679 BQ000607 AI613288 CD671378 AA668936 
    BF196961 BM353589 CA449480 BQ025869 AI934351 AI753571 AA999970 AA812031 

    highest scoring ESTs for WAC:

    N32178 AA012957 AA018507 AA019945 AA019954 AA031552 AA036642 AA059035 AA132911 AA164243 

    Unigene Cluster for WAC:

    WW domain containing adaptor with coiled-coil
    Hs.714700  [show with all ESTs]
    Unigene Representative Sequence: NM_016628


    GeneLoc Exon Structure

    5/17 Alternative Splicing Database (ASD) splice patterns (SP) for WAC (see all 17 )

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b ^ 11a · 11b · 11c ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16a · 16b ·
    SP1:        -     -           -     -     -                 -                       -                                                           -     -         
    SP2:                                                                                -     -     -     -                                         -     -         
    SP3:        -     -           -     -     -                 -                       -     -     -     -                                                         
    SP4:              -           -     -     -                 -                       -                                                                           
    SP5:                                                                                -     -     -     -                                         -     -         

    ExUns: 16c ^ 17 ^ 18a · 18b · 18c ^ 19a · 19b · 19c ^ 20a · 20b
    SP1:              -                       -     -               
    SP2:              -                       -     -               
    SP3:                                                            
    SP4:                                                            
    SP5:              -                                             

    About this scheme

    ECgene alternative splicing isoforms for WAC

    6 Ensembl transcripts including schematic representations:
    ENST00000375646  ENST00000345541  ENST00000338396  ENST00000375664  ENST00000354911  ENST00000347934  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    WAC expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for WAC

    1 / 2 / 3

    13 probe-sets matching WAC gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    43448_at2, 3 U95-B 1 1.00 1.00 0.83 0.73 AW006005 0.80 1.00 0.91 1
    46244_g_at2, 3 U95-B 1 1.00 1.00 0.74 0.89 T65035 0.80 1.00 0.91 1

    46243_at2, 3 U95-B 1 1.00 1.00 0.78 1.08 T65035 0.80 1.00 0.91 1
    60884_g_at2, 3 U95-C 1 1.00 1.00 0.78 0.94 AW009398 0.40 1.00 0.76 1

    45348_at2, 3 U95-B 1 0.94 1.00 0.59 1.38 N32178 1.00 1.00 1.00 1

    222390_at2, 3 U133-B 1 1.00 1.00 -- -- AL135461 0.80 1.00 0.91 1

    219679_s_at2, 3 U133-A 1 1.00 1.00 -- -- NM_018604 0.20 1.00 0.72 1

    222389_s_at2, 3 U133-B 1 1.00 1.00 -- -- BE879807 0.80 1.00 0.91 1

    217742_s_at2, 3 U133-A 1 1.00 1.00 -- -- NM_016628 0.60 1.00 0.82 1

    222390_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    219679_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    222389_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    217742_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    GeneDecks  WAC for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: TTAAAACAAA

    SOURCE GeneReport for Unigene cluster: Hs.714700
    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for WAC gene from 5/8 species (see all 8 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    chimpanzee
    (Pan troglodytes)
    WAC1   -- WW domain containing adaptor with coiled-coil 99.74(n)
    99.53(a)
    450378  XM_507721.2  XP_507721.2 
    cow
    (Bos taurus)
    WAC1   -- WW domain containing adaptor with coiled-coil 95.22(n)
    97.29(a)
    532597  XM_611722.3  XP_611722.3 
    mouse
    (Mus musculus)
    Wac1, 5 185
    WW domain containing adaptor with coiled-coil1, 5 92.78(n)1
    95.05(a)1
    2251311  NM_153085.21  NP_694725.21 
     AF3209965  AI2567355  (see all 25)
    chicken
    (Gallus gallus)
    WAC1   -- WW domain containing adaptor with coiled-coil 88.39(n)
    91.45(a)
    428414  XM_425975.2  XP_425975.2 
    zebrafish
    (Danio rerio)
    wufc13f042   -- wufc13f04 77.66(n) 323904  BC048888.1 
    About this table        Species with no ortholog for WAC

    ENSEMBL Gene Tree for WAC
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

      --
    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/447 NCBI SNPs in WAC are shown (see all 447 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 144)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 10 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs22327911,2
    C,F,H28937126(+) AATCTA/GCATCA 3 T/A mis1 ese34Minor allele frequency- G:0.01EU EA WA 406
    rs71271,2
    C,F28945142(-) AGAAGT/AATGAT 3 S/T mis11Minor allele frequency- A:0.02MN 184
    --
    rs123603261,2
    H28945250(+) AAAATC/TTCATA 3 L/F mis14Minor allele frequency- T:0.00EU EA WA 406
    rs115959261,2
    H28924783(+) AGTAGT/ATCTAC 3 R/S mis1 int1 ese34Minor allele frequency- A:0.00EU EA WA 418
    rs341205021,2
    F28946711(-) TGCTCT/CCGCAA 3 R/R syn11Minor allele frequency- C:0.03NA 78
    rs3321441,2
    A,C,F,H,O28907961(+) AAGTCG/ATTCCC 3 -- int124Minor allele frequency- A:0.41NS NA EU EA WA 1864
    rs25327411,2
    A,C,F,H,O28903814(+) TTTTTC/GACTGC 3 -- int1 trp311Minor allele frequency- G:0.44EU EA WA NA 974
    rs3321331,2
    A,C,F,H,O28894646(+) ATGCTG/AATTTT 3 -- int18Minor allele frequency- A:0.36MN EU EA WA NA 744
    rs3321391,2
    A,C,F,H,O28899085(-) GTAGCA/GTATTA 3 -- int121Minor allele frequency- G:0.12NS MN NA EU EA WA 1690
    rs28077591,2
    A,C,F,H,O28877617(-) TAACAT/CGGGTA 3 -- int17Minor allele frequency- C:0.10NA EU EA WA 558
    About this table

    HapMap Linkage Disequilibrium images for WAC (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

      --

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/19 PubMed articles for WAC gene (see all 19 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 51322 HGNC: 17327 AceView: WAC Ensembl:ENSG00000095787 euGenes: HUgn51322
    ECgene: WAC H-InvDB: WAC
    (According to HUGE)
    About This Section

    HUGE: KIAA1844
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

      --
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for WAC:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
      Invitrogen Antibodies  Invitrogen Assays
      Invitrogen Clones  Invitrogen Q-PCR Products
      Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for WAC-related products

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services


     Predesigned and custom siRNAs for WAC Browse antibodies at Sigma-Aldrich
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for WAC Browse small molecules at Sigma-Aldrich
     "Your Favorite Gene" Pathwaysfeedback


      
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