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VWF Gene

protein-coding   GIFtS: 70
GCID: GC12M006058

Von Willebrand Factor


(Previous symbol: F8VWF)
  See VWF-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Von Willebrand Factor1 2
F8VWF1 2 3
VWD2
Coagulation Factor VIII VWF2
vWF3
F85

External Ids:    HGNC: 127261   Entrez Gene: 74502   Ensembl: ENSG000001107997   OMIM: 6131605   UniProtKB: P042753   

Export aliases for VWF gene to outside databases

Previous GC identifers: GC12M005930 GC12M005928 GC12M005917


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for VWF Gene:
The glycoprotein encoded by this gene functions as both an antihemophilic factor carrier and a platelet-vessel
wall mediator in the blood coagulation system. It is crucial to the hemostasis process. Mutations in this gene or
deficiencies in this protein result in von Willebrand's disease. An unprocessed pseudogene has been found on
chromosome 22. (provided by RefSeq, Jul 2008)

GeneCards Summary for VWF Gene:
VWF (von Willebrand factor) is a protein-coding gene. Diseases associated with VWF include von willebrand's disease, and type 1 von willebrand disease. GO annotations related to this gene include protein homodimerization activity and protein N-terminus binding. An important paralog of this gene is MUC5AC.

UniProtKB/Swiss-Prot: VWF_HUMAN, P04275
Function: Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular
injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor
complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury,
stabilizing its heterodimeric structure and protecting it from premature clearance from plasma

Gene Wiki entry for VWF (Von Willebrand factor) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NC_018923.2  NT_009759.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the VWF gene promoter:
         AML1a   Chx10   MyoD   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidVWF promoter sequence
   Search Chromatin IP Primers for VWF

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat VWF


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13.3   Ensembl cytogenetic band:  12p13.31   HGNC cytogenetic band: 12p13.3

VWF Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
VWF gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M006058:  view genomic region     (about GC identifiers)

Start:
6,058,040 bp from pter      End:
6,233,936 bp from pter
Size:
175,897 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: VWF_HUMAN, P04275 (See protein sequence)
Recommended Name: von Willebrand factor precursor  
Size: 2813 amino acids; 309265 Da
Subunit: Multimeric. Interacts with F8
Sequence caution: Sequence=AAB59512.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of
unknown origin in the N-terminal part;
Selected PDB 3D structures from and Proteopedia for VWF (see all 26):
1AO3 (3D)        1ATZ (3D)        1AUQ (3D)        1FE8 (3D)        1FNS (3D)        1IJB (3D)    
Secondary accessions: Q99806

Explore the universe of human proteins at neXtProt for VWF: NX_P04275

Explore proteomics data for VWF at MOPED

Post-translational modifications: 

  • All cysteine residues are involved in intrachain or interchain disulfide bonds1
  • N- and O-glycosylated1
  • Ubiquitination2 at Lys1720
  • Glycosylation2 at Asn99, Asn156, Asn211, Asn666, Asn857, Asn1147, Asn1231, Thr1248, Thr1255, Thr1256,
                                 Ser1263, Thr1468, Thr1477, Ser1486, Thr1487, Asn1515, Asn1574, Thr1679, Asn2223, Asn2290 (see all 26)
  • Modification sites at PhosphoSitePlus

  • See VWF Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000543.2  
    ENSEMBL proteins: 
     ENSP00000261405   ENSP00000461331   ENSP00000459134   ENSP00000461318  
    Reactome Protein details: P04275

    VWF Human Recombinant Protein Products:

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    Novus Biologicals VWF Protein
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    Sino Biological Cell Lysate for VWF
    ProSpec Recombinant Protein for VWF
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for VWF 

    VWF Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of VWF
    R&D Systems Antibodies for VWF (vWF-A2)
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    VWF Assay Products:

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    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for VWF 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ENDOLIG: Endogenous ligands

    Selected InterPro protein domains (see all 7):
     IPR014853 Unchr_dom_Cys-rich
     IPR006207 Cys_knot_C
     IPR012011 VWF
     IPR002919 TIL_dom
     IPR001007 VWF_C

    Graphical View of Domain Structure for InterPro Entry P04275

    ProtoNet protein and cluster: P04275

    Selected Blocks protein domains (see all 6):
    IPB001007 von Willebrand factor
    IPB001839 Transforming growth factor beta (TGFb)
    IPB001846 Von Willebrand factor
    IPB002035 Von Willebrand factor type A domain signature
    IPB002919 Trypsin inhibitor-like


    UniProtKB/Swiss-Prot: VWF_HUMAN, P04275
    Domain: The von Willebrand antigen 2 is required for multimerization of vWF and for its targeting to storage
    granules
    Similarity: Contains 1 CTCK (C-terminal cystine knot-like) domain
    Similarity: Contains 4 TIL (trypsin inhibitory-like) domains
    Similarity: Contains 3 VWFA domains
    Similarity: Contains 3 VWFC domains
    Similarity: Contains 4 VWFD domains


    Find genes that share domains with VWF           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: VWF_HUMAN, P04275
    Function: Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular
    injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor
    complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury,
    stabilizing its heterodimeric structure and protecting it from premature clearance from plasma

         Genatlas biochemistry entry for VWF:
    coagulation factor VIII (von Willebrand factor),expressed in endothelial megakaryocytes,stored in platelets
    alpha-granules and within the Weibel-Palade bodies of epitheliall cells and released into the plasma forming
    disulfide-linked multimeric structure,assembled from dimers

         Gene Ontology (GO): Selected molecular function terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001948glycoprotein binding IDA16409464
    GO:0002020protease binding IPI12775718
    GO:0005178integrin binding IPI9079671
    GO:0005515protein binding IPI11943773
    GO:0005518collagen binding IDA2056120
         
    Find genes that share ontologies with VWF           About GenesLikeMe


    Phenotypes:
         4 GenomeRNAi human phenotypes for VWF:
     Cell cycle / mitosis defect  Decreased NANOG protein expres  Decreased OCT4 protein express  Decreased POU5F1-GFP protein e 

         9 MGI mutant phenotypes (inferred from 7 alleles(MGI details for Vwf):
     cardiovascular system  cellular  digestive/alimentary  hematopoietic system  homeostasis/metabolism 
     immune system  mortality/aging  nervous system  no phenotypic analysis 

    Find genes that share phenotypes with VWF           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Vwftm1Wgr for VWF

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for VWF
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for VWF

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for VWF
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for VWF

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    hsa-miR-4265 hsa-miR-4296
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for VWF
    Predesigned siRNA for gene silencing in human, mouse, rat VWF

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for VWF

    Clone
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    OriGene ORF clones in mouse, rat for VWF
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: VWF (NM_000552)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for VWF
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat VWF

    Cell Line
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    Flow Cytometry
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    eBioscience FlowRNA Probe Sets ( VA1-12338) for VWF 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    VWF_HUMAN, P04275: Secreted. Secreted, extracellular space, extracellular matrix. Note=Localized to storage
    granules
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    extracellular5
    cytoskeleton3
    golgi apparatus2
    nucleus2
    plasma membrane2
    lysosome1
    mitochondrion1
    vacuole1

    Gene Ontology (GO): Selected cellular component terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005578proteinaceous extracellular matrix IEA--
    GO:0005783endoplasmic reticulum IDA6754744
    GO:0009897external side of plasma membrane IEA--
    GO:0031012extracellular matrix IDA6754744

    Find genes that share ontologies with VWF           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for VWF About   (see all 12)  
    See pathways by source

    SuperPathContained pathways About
    1Formation of Fibrin Clot (Clotting Cascade)
    Formation of Fibrin Clot (Clotting Cascade)0.51
    Blood Clotting Cascade0.42
    Blood Coagulation Signaling Pathways0.51
    Intrinsic Pathway0.00
    2Focal adhesion
    Focal adhesion0.65
    ECM-receptor interaction0.31
    Focal Adhesion0.65
    3Complement and coagulation cascades
    Complement and coagulation cascades0.71
    Complement and Coagulation Cascades0.71
    4Integrin alphaIIb beta3 signaling
    Integrin alphaIIb beta3 signaling0.73
    GRB2-SOS provides linkage to MAPK signaling for Intergrins0.00
    Platelet Aggregation (Plug Formation)0.73
    p130Cas linkage to MAPK signaling for integrins0.00
    5Response to elevated platelet cytosolic Ca2+
    Response to elevated platelet cytosolic Ca2+0.94
    Platelet degranulation0.94


    Find genes that share SuperPaths with VWF           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for VWF
        Blood Coagulation Signaling Pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for VWF
        Blood Coagulation Cascade
    Intrinsic Prothrombin Activation Pathway

    3 BioSystems Pathways for VWF
        Focal Adhesion
    Blood Clotting Cascade
    Complement and Coagulation Cascades


    Selected Reactome Pathways for VWF (see all 8)
        Platelet Adhesion to exposed collagen
    Integrin cell surface interactions
    Intrinsic Pathway
    GP1b-IX-V activation signalling
    p130Cas linkage to MAPK signaling for integrins

    1 PharmGKB Pathway for VWF
        Platelet Aggregation Inhibitor Pathway, Pharmacodynamics

    4 Kegg Pathways  (Kegg details for VWF):
        PI3K-Akt signaling pathway
    Focal adhesion
    ECM-receptor interaction
    Complement and coagulation cascades

        Pathway & Disease-focused RT2 Profiler PCR Arrays including VWF: 
              Cell Surface Markers in human mouse rat
              Endothelial Cell Biology in human mouse rat
              Atherosclerosis in human mouse rat
              Mesenchymal Stem Cell in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for VWF

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for VWF (P042751, 2, 3 ENSP000002614054) via UniProtKB, MINT, STRING, and/or I2D (see all 47)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ZNF512BQ96KM62, 3MINT-60830 I2D: score=2 
    VWFP042751, 2EBI-981819,EBI-981819 MINT-8289100
    GP1BAP073591, 2, 3, ENSP000003293804EBI-981819,EBI-297082 MINT-17868 MINT-24838 I2D: score=3 STRING: ENSP00000329380
    ADAMTS13Q76LX81, 3, ENSP000003609974EBI-981819,EBI-981764 I2D: score=3 STRING: ENSP00000360997
    CALRP277973, ENSP000003208664I2D: score=3 STRING: ENSP00000320866
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001889liver development IEA--
    GO:0001890placenta development IEA--
    GO:0002576platelet degranulation TAS--
    GO:0007155cell adhesion IDA10764791
    GO:0007596blood coagulation TAS--

    Find genes that share ontologies with VWF           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for VWF

    1 DrugBank Compound for VWF    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Antihemophilic FactorAHF (see all 3)--targetbinder2942172 2128855 14750934 11858481 10938981

    Selected Novoseek inferred chemical compound relationships for VWF gene (see all 135)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ristocetin 97.1 956 7887899 (6), 19694940 (5), 17977030 (5), 14757772 (4) (see all 99)
    desmopressin 91.1 630 11992235 (10), 7690994 (6), 17164493 (6), 2108732 (6) (see all 99)
    fibrinogen 87.2 964 17650077 (9), 17622488 (7), 15745313 (7), 9416937 (6) (see all 99)
    crotalin 72.1 3 9473223 (2)
    calin 66 5 9490916 (1), 9164855 (1), 7833474 (1), 10494781 (1)
    aurintricarboxylic acid 65.6 39 1287886 (4), 18957047 (2), 7749846 (1), 9459348 (1) (see all 16)
    adp 64.9 103 2154674 (3), 2401846 (3), 8051492 (3), 2346725 (2) (see all 56)
    kogenate 63.9 9 7639276 (2), 18078401 (2), 7483501 (1), 11122270 (1) (see all 6)
    koate-hp 63.7 2 11563592 (1), 8191394 (1)
    rfviii 61.2 15 10456452 (2), 8199023 (1), 8652394 (1), 18983499 (1) (see all 7)



    Find genes that share compounds with VWF           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for VWF gene: 
    NM_000552.3  

    Unigene Cluster for VWF:

    Von Willebrand factor
    Hs.440848  [show with all ESTs]
    Unigene Representative Sequence: NM_000552
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000261405(uc001qnn.1 uc010set.1) ENST00000538635 ENST00000539641
    ENST00000321023 ENST00000538563 ENST00000545906 ENST00000540192 ENST00000572068(uc001qno.1)

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    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: VWF (NM_000552)
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    Primer
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    Flow Cytometry
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    Additional mRNA sequence: 

    AF086470.1 AK128487.1 AK292122.1 AK297600.1 BC022258.1 BC069030.1 K03028.1 M10321.1 
    M17588.1 U81237.1 X02672.1 X04146.1 X04385.1 

    21 DOTS entries:

    DT.91762387  DT.95170468  DT.121129090  DT.121129141  DT.100788530  DT.121129143  DT.100788527  DT.121129166 
    DT.97790477  DT.97846422  DT.121129157  DT.40121611  DT.95170466  DT.99966582  DT.429976  DT.91762385 
    DT.95292632  DT.75146000  DT.91762382  DT.95170467  DT.121129186 

    Selected AceView cDNA sequences (see all 349):

    CA426966 BM978014 AL549326 AW088268 BM931624 CB266691 BC069030 AA683280 
    CB266865 BM992949 BQ882131 BQ722193 M17588 BQ004477 X04385 BU732004 
    AU140314 AA457534 AA323834 BQ029045 BM699079 AU158381 CB267322 BX457215 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for VWF (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^
    SP1:                    -     -                             -                                                                                                   
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35 ^ 36 ^ 37 ^ 38a · 38b ^ 39a · 39b ^ 40 ^ 41 ^ 42 ^ 43 ^ 44 ^ 45 ^ 46 ^ 47a ·
    SP1:                                                                                                        -                                               -   
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 47b ^ 48 ^ 49a · 49b ^ 50a · 50b ^ 51 ^ 52 ^ 53
    SP1:              -                 -                     
    SP2:                                                      
    SP3:              -                                       
    SP4:                                                      
    SP5:                                                      


    ECgene alternative splicing isoforms for VWF

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    VWF expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTCTGCTCTT
    VWF Expression
    About this image


    VWF expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 24) fully expand
     
     Endothelium (Cardiovascular System)    fully expand to see all 39 entries
             Pericytes Microvessels
             Human umbilical vein endothelial cells (HUVEC)
             UEA-1 isolated cells
             Human Aortic Endothelial Cells (HAEC)   
     
     Umbilical Cord (Extraembryonic Tissues)    fully expand to see all 6 entries
             Umbilical cord blood-derived endothelial progenitor cells
             Human Umbilical Artery Endothelial Cells (HUAEC)   
     
     Blood (Hematopoietic System)    fully expand to see all 4 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
             Angiogenic cell precursor
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
             Brain microvascular endothelial cells
             Human Brain Microvascular Endothelial Cells (HBMEC)   
     
     Heart (Cardiovascular System)    fully expand to see all 5 entries
             Endocardial Tube Cells Endocardium
             Heart Tube
             Cardiac progenitor cells
             Human Pulmonary Artery Endothelial Cells (HPAEC)   
    VWF Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    VWF Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.440848

    UniProtKB/Swiss-Prot: VWF_HUMAN, P04275
    Tissue specificity: Plasma

        Pathway & Disease-focused RT2 Profiler PCR Arrays including VWF: 
              Cell Surface Markers in human mouse rat
              Endothelial Cell Biology in human mouse rat
              Atherosclerosis in human mouse rat
              Mesenchymal Stem Cell in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for VWF
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat VWF
    QuantiTect SYBR Green Assays in human, mouse, rat VWF
    QuantiFast Probe-based Assays in human, mouse, rat VWF
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VWF

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for VWF gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Vwf1 , 5 Von Willebrand factor homolog1, 5 83.68(n)1
    83.4(a)1
      6 (59.32 cM)5
    223711  NM_011708.41  NP_035838.31 
     1255467745 
    chicken
    (Gallus gallus)
    Aves VWF1 von Willebrand factor 61.71(n)
    56.63(a)
      419031  XM_417223.4  XP_417223.3 
    lizard
    (Anolis carolinensis)
    Reptilia VWF6
    Uncharacterized protein
    55(a)
    1 ↔ 1
    5(81821509-82024856)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia vwf1 von Willebrand factor 60.41(n)
    55.42(a)
      100492314  NM_001256288.1  NP_001243217.1 
    zebrafish
    (Danio rerio)
    Actinopterygii vwf1 von Willebrand factor 56.17(n)
    47.62(a)
      570643  XM_002665310.3  XP_002665356.3 
    fruit fly
    (Drosophila melanogaster)
    Insecta Hml3 defense response sugar binding 30(a)   70C4   --


    ENSEMBL Gene Tree for VWF (if available)
    TreeFam Gene Tree for VWF (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for VWF gene
    MUC5AC2  ZAN2  TECTA2  MUC22  OTOG2  OTOGL2  MUC62  MUC192  
    FCGBP2  BMPER2  
    3 SIMAP similar genes for VWF using alignment to 5 protein entries:     VWF_HUMAN (see all proteins):
    COL21A1    FCGBP    MG1

    Find genes that share paralogs with VWF           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for VWF
    PGOHUM00000246202


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for VWF (see all 5204)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs617506151,2,,4
    C,FVon Willebrand disease 3 (VWD3)4 untested16035142(-) TCACTC/TCACAA 2 P S mis12Minor allele frequency- T:0.01NA EU 5875
    rs412767381,2,,4
    C,FVon Willebrand disease 2 (VWD2)4 pathogenic16075456(+) ACTTCC/TGGTCC 2 Q R mis14Minor allele frequency- T:0.00NA EU 5871
    rs617539971,2,,4
    CVon Willebrand disease 3 (VWD3)4 untested16116089(-) ACGCCC/TGGACC 2 R W mis11Minor allele frequency- T:0.00NA 4548
    VAR_0058084
    Von Willebrand disease 2 (VWD2)4--see VAR_0058082 F C mis40--------
    VAR_0057924
    Von Willebrand disease 2 (VWD2)4--see VAR_0057922 H D mis40--------
    VAR_0058114
    Von Willebrand disease 2 (VWD2)4--see VAR_0058112 R G mis40--------
    VAR_0058144
    Von Willebrand disease 2 (VWD2)4--see VAR_0058142 V D mis40--------
    VAR_0057834
    Von Willebrand disease 2 (VWD2)4--see VAR_0057832 N S mis40--------
    VAR_0057944
    Von Willebrand disease 2 (VWD2)4--see VAR_0057942 R W mis40--------
    VAR_0058154
    Von Willebrand disease 2 (VWD2)4--see VAR_0058152 G R mis40--------

    HapMap Linkage Disequilibrium report for VWF (6058040 - 6233936 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for VWF:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2549788CNV Deletion19546169
    nsv509451CNV Insertion20534489
    esv269412CNV Insertion20981092
    dgv1350n71CNV Loss21882294
    nsv832320CNV Loss17160897
    nsv898631CNV Loss21882294
    nsv468988CNV Gain19166990
    nsv470262CNV Gain18288195
    esv26513CNV Gain19812545
    nsv898628CNV Gain21882294

    Human Gene Mutation Database (HGMD): VWF
    Locus Specific Mutation Databases (LSDB): VWF

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing VWF
    DNA2.0 Custom Variant and Variant Library Synthesis for VWF

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 613160   
    OMIM disorders: 613554  193400  277480  
    UniProtKB/Swiss-Prot: VWF_HUMAN, P04275
  • von Willebrand disease 1 (VWD1) [MIM:193400]: A common hemorrhagic disorder due to defects in von
    Willebrand factor protein and resulting in impaired platelet aggregation. Von Willebrand disease type 1 is
    characterized by partial quantitative deficiency of circulating von Willebrand factor, that is otherwise
    structurally and functionally normal. Clinical manifestations are mucocutaneous bleeding, such as epistaxis and
    menorrhagia, and prolonged bleeding after surgery or trauma. Note=The disease is caused by mutations affecting
    the gene represented in this entry
  • von Willebrand disease 2 (VWD2) [MIM:613554]: A hemorrhagic disorder due to defects in von Willebrand
    factor protein and resulting in altered platelet aggregation. Von Willebrand disease type 2 is characterized by
    qualitative deficiency and functional anomalies of von Willebrand factor. It is divided in different subtypes
    including 2A, 2B, 2M and 2N (Normandy variant). The mutant VWF protein in types 2A, 2B and 2M are defective in
    their platelet-dependent function, whereas the mutant protein in type 2N is defective in its ability to bind
    factor VIII. Clinical manifestations are mucocutaneous bleeding, such as epistaxis and menorrhagia, and prolonged
    bleeding after surgery or trauma. Note=The disease is caused by mutations affecting the gene represented in this
    entry
  • von Willebrand disease 3 (VWD3) [MIM:277480]: A severe hemorrhagic disorder due to a total or near total
    absence of von Willebrand factor in the plasma and cellular compartments, also leading to a profound deficiency
    of plasmatic factor VIII. Bleeding usually starts in infancy and can include epistaxis, recurrent mucocutaneous
    bleeding, excessive bleeding after minor trauma, and hemarthroses. Note=The disease is caused by mutations
    affecting the gene represented in this entry

  • Selected diseases for VWF (see all 37):    
    About MalaCards
    von willebrand's disease    type 1 von willebrand disease    type 3 von willebrand disease    qualitative platelet defect
    von willebrand disease, types 2a, 2b, 2m, and 2n    type 2m von willebrand disease    acquired von willebrand syndrome    von willibrand disease, type 3
    type 2a von willebrand disease    thrombotic thrombocytopenic purpura    type 2b von willebrand disease    eisenmenger syndrome
    type 2n von willebrand disease    angiodysplasia    mild hemophilia a    autoimmune polyglandular syndrome type 3
    intermittent claudication    fainting    hemarthrosis    coronary thrombosis

    14 diseases from the University of Copenhagen DISEASES database for VWF:
    Von Willebrand's disease     Vascular disease     Thrombophilia     Bernard-Soulier syndrome
    Thrombocytopenia     Heart disease     Glanzmann's thrombasthenia     Diabetes mellitus
    Brain disease     Anemia     Cancer     Connective tissue disease
    Kidney failure     Hypersensitivity reaction type II disease

    Find genes that share disorders with VWF           About GenesLikeMe

    Selected Novoseek inferred disease relationships for VWF gene (see all 96)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    von willebrand disease 97.8 680 8456322 (3), 8236134 (3), 9684782 (3), 1409710 (3) (see all 99)
    purpura thrombotic thrombocytopenic 87.5 100 8438900 (4), 19190805 (2), 9535389 (1), 10227776 (1) (see all 77)
    prolonged bleeding time 82.7 61 7750191 (2), 9881332 (1), 10583513 (1), 11601234 (1) (see all 38)
    von willebrand disease, platelet-type 82.2 11 19951970 (1), 1911886 (1), 7660135 (1), 12637314 (1) (see all 8)
    coagulopathy 81 122 8500791 (2), 18333911 (2), 9873810 (2), 8328650 (1) (see all 99)
    hemophilia a 78.4 41 8500791 (2), 8490173 (2), 8634427 (2), 19506355 (2) (see all 25)
    bleeding tendency 78 41 1284714 (2), 18055987 (2), 19506363 (1), 10595636 (1) (see all 27)
    bernard-soulier syndrome 76.3 12 8000916 (1), 8770359 (1), 20462086 (1), 7900092 (1) (see all 10)
    thrombosis 74.2 185 7823669 (4), 8490173 (4), 11380453 (2), 15870546 (2) (see all 99)
    bleeding 72.3 511 20008188 (5), 8562836 (4), 15166918 (4), 9766795 (3) (see all 99)

    Genatlas disease: VWF
    Willebrand disease,types I,II A and II B and recessive form

    GeneTests: VWF
    GeneReviews: VWF
    Genetic Association Database (GAD): VWF
    Human Genome Epidemiology (HuGE) Navigator: VWF (99 documents)

    Export disorders for VWF gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for VWF gene, integrated from 10 sources (see all 2729) (see top 10):
    (articles sorted by number of sources associating them with VWF)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel von Willebrand disease-causing mutation (Arg273Trp) in the von Willebrand factor propeptide that results in defective multimerization and secretion. (PubMed id 10887119)1, 2, 9 Allen S.... Daly M.E. (Blood 2000)
    2. von Willebrand factor storage and multimerization: 2 independent intracellular processes. (PubMed id 10961880)1, 2, 9 Haberichter S.L.... Montgomery R.R. (Blood 2000)
    3. The ABO blood group genotype and factor VIII levels as independent risk factors for venous thromboembolism. (PubMed id 15735796)1, 4, 9 Tirado I....Fontcuberta J. (Thromb. Haemost. 2005)
    4. Measurement of von Willebrand factor-FVIII binding activity in patients with suspected von Willebrand disease type 2N: application of an ELISA-based assay in a reference laboratory. (PubMed id 19298374)1, 4, 9 Zhukov O....Sahud M. (Haemophilia 2009)
    5. The Sma I polymorphism in the von Willebrand factor gene associated with acute ischemic stroke. (PubMed id 11755948)1, 4, 9 Dai K....Ruan C. (Thromb. Res. 2001)
    6. von Willebrand disease type B: a missense mutation selectively abolishes ristocetin-induced von Willebrand factor binding to platelet glycoprotein Ib. (PubMed id 1409710)1, 2, 9 Rabinowitz I.... Sadler J.E. (Proc. Natl. Acad. Sci. U.S.A. 1992)
    7. Distribution of von Willebrand factor levels in young women with and without bleeding symptoms: influence of ABO blood group and promoter haplotypes. (PubMed id 18521502)1, 4, 9 Lethagen S....Friberg B. (Thromb. Haemost. 2008)
    8. The A/T1381 polymorphism in the A1-domain of von Willebrand factor influences the affinity of von Willebrand factor for platelet glycoprotein Ibalpha. (PubMed id 17598011)1, 4, 9 SzA!ntA^ T....Vanhoorelbeke K. (Thromb. Haemost. 2007)
    9. Genetic variability of von Willebrand factor and risk of coronary heart disease: the Rotterdam Study. (PubMed id 14717782)1, 4, 9 van der Meer I.M....GA^mez GarcA-a E.B. (Br. J. Haematol. 2004)
    10. Defective dimerization of von Willebrand factor subunits due to a Cys-> Arg mutation in type IID von Willebrand disease. (PubMed id 8622978)1, 2, 9 Schneppenheim R.... Ruggeri Z.M. (Proc. Natl. Acad. Sci. U.S.A. 1996)
    11. Identification of two mutations (Arg611Cys and Arg611His) in the A1 loop of von Willebrand factor (vWF) responsible for type 2 von Willebrand disease with decreased platelet-dependent function of vWF. (PubMed id 7620154)1, 2, 9 Hilbert L.... Mazurier C. (Blood 1995)
    12. Characterization of the von Willebrand factor gene (VWF) in von Willebrand disease type III patients from 24 families of Swedish and Finnish origin. (PubMed id 8088787)1, 2, 9 Zhang Z.P.... Anvret M. (Genomics 1994)
    13. Association between von Willebrand factor gene polymorphism and preeclampsia. (PubMed id 19021456)1, 4, 9 Sun C....Yu S. (J Perinat Med 2009)
    14. Platelet GPIbalpha, GPIV and vWF polymorphisms and fatal pre-hospital MI among middle-aged men. (PubMed id 17619827)1, 4, 9 Pellikka M....Mikkelsson J. (J. Thromb. Thrombolysis 2008)
    15. Effect of von Willebrand factor Y/C1584 on in vivo protein level and function and interaction with ABO blood group. (PubMed id 17119126)1, 4, 9 Davies J.A....Bowen D.J. (Blood 2007)
    16. Impact of the Thr789Ala variant of the von Willebrand factor levels, on ristocetin co-factor and collagen binding capacity and its association with coronary heart disease in patients with diabetes mellitus type 2. (PubMed id 16320153)1, 4, 9 Klemm T....Paschke R. (amp 2005)
    17. von Willebrand factor, platelets and endothelial cell interactions. (PubMed id 12871266)1, 2, 9 Ruggeri Z.M. (J. Thromb. Haemost. 2003)
    18. Association studies between -1185A/G von Willebrand factor gene polymorphism and coronary artery disease. (PubMed id 12792699)1, 4, 9 Simon D....Roisenberg I. (Braz. J. Med. Biol. Res. 2003)
    19. High factor VIII antigen levels increase the risk of venous thrombosis but are not associated with polymorphisms in the von Willebrand factor and factor VIII gene. (PubMed id 11722428)1, 4, 9 Kamphuisen P.W....Bertina R.M. (Br. J. Haematol. 2001)
    20. The -1185 A/G and -1051 G/A dimorphisms in the von Willebrand factor gene promoter and risk of myocardial infarction. (PubMed id 11736957)1, 4, 9 Di Bitondo R....Winship P.R. (Br. J. Haematol. 2001)
    21. Activation of human platelets by the membrane-expressed A1 domain of von Willebrand factor. (PubMed id 9373253)1, 2, 9 Schulte am Esch J. II...Robson S.C. (Blood 1997)
    22. Identification of a candidate missense mutation in a family with von Willebrand disease type IIC. (PubMed id 7789955)1, 2, 9 Schneppenheim R.... Zeiger B. (Hum. Genet. 1995)
    23. Investigation of type IIC von Willebrand disease. (PubMed id 8011991)1, 2, 9 Uno H.... Tsuda K. (Int. J. Hematol. 1994)
    24. Characterization of Leu777Pro and Ile865Thr type IIA von Willebrand disease mutations. (PubMed id 8123844)1, 2, 9 Lyons S.E.... Ginsburg D. (Blood 1994)
    25. Substitution of cysteine for phenylalanine 751 in mature von Willebrand factor is a novel candidate mutation in a family with type IIA von Willebrand disease. (PubMed id 8435341)1, 2, 9 Gaucher C.... Mazurier C. (Br. J. Haematol. 1993)
    26. Identification of three candidate mutations causing type IIA von Willebrand disease using a rapid, nonradioactive, allele-specific hybridization method. (PubMed id 8338947)1, 2, 9 Inbal A.... Sadler J.E. (Blood 1993)
    27. Molecular study of von Willebrand disease: identification of potential mutations in patients with type IIA and type IIB. (PubMed id 1420817)1, 2, 9 Pietu G.... Meyer D. (Blood Coagul. Fibrinolysis 1992)
    28. Germ-line mosaicism for a valine-to-methionine substitution at residue 553 in the glycoprotein Ib-binding domain of von Willebrand factor, causing type IIB von Willebrand disease. (PubMed id 1729889)1, 2, 9 Murray E.W.... Lillicrap D. (Am. J. Hum. Genet. 1992)
    29. Defects in type IIA von Willebrand disease: a cysteine 509 to arginine substitution in the mature von Willebrand factor disrupts a disulphide loop involved in the interaction with platelet glycoprotein Ib-IX. (PubMed id 1419804)1, 2, 9 Lavergne J.-M.... Pietu G. (Br. J. Haematol. 1992)
    30. Analysis of the relationship of von Willebrand disease (vWD) and hereditary hemorrhagic telangiectasia and identification of a potential type IIA vWD mutation (IIe865 to Thr). (PubMed id 1673047)1, 2, 9 Iannuzzi M.C.... Ginsburg D. (Am. J. Hum. Genet. 1991)
    31. Molecular basis of von Willebrand disease type IIB. Candidate mutations cluster in one disulfide loop between proposed platelet glycoprotein Ib binding sequences. (PubMed id 2010538)1, 2, 9 Randi A.M.... Sadler J.E. (J. Clin. Invest. 1991)
    32. C1272F: a novel type 2A von Willebrand's disease mutation in A1 domain; its clinical significance. (PubMed id 21592258)1, 2 Woods A.I....Lazzari M.A. (Haemophilia 2012)
    33. New gene functions in megakaryopoiesis and platelet formation. (PubMed id 22139419)1, 4 Gieger C....Soranzo N. (Nature 2011)
    34. Variation in the von Willebrand factor gene is associated with von Willebrand factor levels and with the risk for cardiovascular disease. (PubMed id 20940418)1, 4 van Schie M.C....Leebeek F.W. (Blood 2011)
    35. Accumulation of gene polymorphisms related to plaque disruption and thrombosis is associated with cerebral infarction in subjects with type 2 diabetes. (PubMed id 19933990)1, 4 Katakami N....Yamasaki Y. (Diabetes Care 2010)
    36. Increased serum vWF and sVCAM-1 levels are associated with late or very late angiographic stent thrombosis after sirolimus-eluting stent implantation. (PubMed id 20508517)1, 4 Jin C....Shen W.F. (Coron. Artery Dis. 2010)
    37. von Willebrand factor variant p.Arg924Gln marks an allele associated with reduced von Willebrand factor and factor VIII levels. (PubMed id 20492463)1, 4 Hickson N....Goodeve A. (J. Thromb. Haemost. 2010)
    38. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    39. Population based allele frequencies of disease associated polymorphisms in the Personalized Medicine Research Project. (PubMed id 20565774)1, 4 Cross D.S....McCarty C.A. (BMC Genet. 2010)
    40. Common VWF exon 28 polymorphisms in African Americans affecting the VWF activity assay by ristocetin cofactor. (PubMed id 20231421)1, 4 Flood V.H....Montgomery R.R. (Blood 2010)
    41. Hemostatic gene polymorphisms in young Sardinian with non-fatal acute myocardial infarction. (PubMed id 20036902)1, 4 Musino L....Carru C. (Front Biosci (Elite Ed) 2010)
    42. Human variation in alcohol response is influenced by variation in neuronal signaling genes. (PubMed id 20201926)1, 4 Joslyn G....White R.L. (Alcohol. Clin. Exp. Res. 2010)
    43. Genetic risk factors for hepatopulmonary syndrome in patients with advanced liver disease. (PubMed id 20346360)1, 4 Roberts K.E....Fallon M.B. (Gastroenterology 2010)
    44. L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism: an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms. (PubMed id 20424473)1, 4 Yokoyama K....Hosoya T. (Nephron Clin Pract 2010)
    45. Identification of fetal and maternal single nucleotide polymorphisms in candidate genes that predispose to spontaneous preterm labor with intact membranes. (PubMed id 20452482)1, 4 Romero R....Menon R. (Am. J. Obstet. Gynecol. 2010)
    46. A genetic association study of maternal and fetal candidate genes that predispose to preterm prelabor rupture of membranes (PROM). (PubMed id 20673868)1, 4 Romero R....Menon R. (Am. J. Obstet. Gynecol. 2010)
    47. Impact of 789Ala/Ala genotype on quantitative type of von Willebrand disease. (PubMed id 18923835)1, 4 Ahmad F....Saxena R. (Ann. Hematol. 2009)
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    64. A novel type 2A (Group II) von Willebrand disease mutation (L1503Q) associated with loss of the highest molecular weight von Willebrand factor multimers. (PubMed id 15219197)1, 4 O'Brien L.A....Lillicrap D. (J. Thromb. Haemost. 2004)
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    68. The contribution of genetic factors to thrombotic and bleeding outcomes in coronary patients randomised to IIb/IIIa antagonists. (PubMed id 12082590)1, 4 Shields D.C....Fitzgerald D.J. (Pharmacogenomics J. 2002)
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    70. Analysis of the -1185A/G von Willebrand factor (VWF) gene polymorphism in two Brazilian ethnic groups and its effect on the plasma VWF levels. (PubMed id 12091053)1, 4 Simon D....Roisenberg I. (Thromb. Res. 2002)
    71. Type 1 von Willebrand disease mutation Cys1149Arg causes intracellular retention and degradation of heterodimers: a possible general mechanism for dominant mutations of oligomeric proteins. (PubMed id 11698279)1, 2 Bodo I.... Sadler J.E. (Blood 2001)
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    78. Effects of different amino-acid substitutions in the leucine 694- proline 708 segment of recombinant von Willebrand factor. (PubMed id 8547152)1, 2 Hilbert L.... Mazurier C. (Br. J. Haematol. 1995)
    79. Genetic heterogeneity of severe von Willebrand disease type III in the German population. (PubMed id 7989040)1, 2 Schneppenheim R....Simeoni E. (Hum. Genet. 1994)
    80. Leu 697-->Val mutation in mature von Willebrand factor is responsible for type IIB von Willebrand disease. (PubMed id 8123843)1, 2 Hilbert L....Mazurier C. (Blood 1994)
    81. von Willebrand factor mutation enhancing interaction with platelets in patients with normal multimeric structure. (PubMed id 8486782)1, 2 Holmberg L....Ruggeri Z.M. (J. Clin. Invest. 1993)
    82. Type IIB mutation His-505-->Asp implicates a new segment in the control of von Willebrand factor binding to platelet glycoprotein Ib. (PubMed id 8376405)1, 2 Rabinowitz I....Sadler J.E. (J. Biol. Chem. 1993)
    83. Two new candidate mutations in type IIA von Willebrand's disease (Arg834-->Gly, Gly846-->Arg) and one polymorphism (Tyr821-->Cys) in the A2 region of the von Willebrand factor. (PubMed id 8348943)1, 2 Donner M.... Holmberg L. (Eur. J. Haematol. 1993)
    84. Characterization of recombinant von Willebrand factor corresponding to mutations in type IIA and type IIB von Willebrand disease. (PubMed id 1429668)1, 2 Ribba A.S.... Pietu G. (J. Biol. Chem. 1992)
    85. Type IIB von Willebrand's disease: gene mutations and clinical presentation in nine families from Denmark, Germany and Sweden. (PubMed id 1419803)1, 2 Donner M.... Holmberg L. (Br. J. Haematol. 1992)
    86. The molecular defect in type IIB von Willebrand disease. Identification of four potential missense mutations within the putative GpIb binding domain. (PubMed id 1672694)1, 2 Cooney K.A.... Ginsburg D. (J. Clin. Invest. 1991)
    87. An Arg545-->Cys545 substitution mutation of the von Willebrand factor in type IIB von Willebrand's disease. (PubMed id 1761120)1, 2 Donner M.... Holmberg L. (Eur. J. Haematol. 1991)
    88. Identification of two point mutations in the von Willebrand factor gene of three families with the 'Normandy' variant of von Willebrand disease. (PubMed id 1832934)1, 2 Gaucher C.... Mazurier C. (Br. J. Haematol. 1991)
    89. Expression of von Willebrand factor 'Normandy': an autosomal mutation that mimics hemophilia A. (PubMed id 1906179)1, 2 Tuley E.A....Mazurier C. (Proc. Natl. Acad. Sci. U.S.A. 1991)
    90. Human von Willebrand factor gene and pseudogene: structural analysis and differentiation by polymerase chain reaction. (PubMed id 1988024)1, 2 Mancuso D.J.... Sadler J.E. (Biochemistry 1991)
    91. Identification of a point mutation in type IIB von Willebrand disease illustrating the regulation of von Willebrand factor affinity for the platelet membrane glycoprotein Ib-IX receptor. (PubMed id 2011604)1, 2 Ware J....Ruggeri Z.M. (Proc. Natl. Acad. Sci. U.S.A. 1991)
    92. Expression of a human proprotein processing enzyme: correct cleavage of the von Willebrand factor precursor at a paired basic amino acid site. (PubMed id 2251280)1, 3 Wise R.J....Kaufman R.J. (Proc. Natl. Acad. Sci. U.S.A. 1990)
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    97. Molecular cloning of the human gene for von Willebrand factor and identification of the transcription initiation site. (PubMed id 3496594)1, 2 Collins C.J.... Lynch D.C. (Proc. Natl. Acad. Sci. U.S.A. 1987)
    98. Identification of disulfide-bridged substructures within human von Willebrand factor. (PubMed id 3502076)1, 2 Marti T.... Walsh K.A. (Biochemistry 1987)
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    101. cDNA sequences for human von Willebrand factor reveal five types of repeated domains and five possible protein sequence polymorphisms. (PubMed id 3488076)1, 2 Shelton-Inloes B.B.... Sadler J.E. (Biochemistry 1986)
    102. Full-length von Willebrand factor (vWF) cDNA encodes a highly repetitive protein considerably larger than the mature vWF subunit. (PubMed id 3019665)1, 2 Verweij C.L.... Pannekoek H. (EMBO J. 1986)
    103. Nucleotide sequence of pre-pro-von Willebrand factor cDNA. (PubMed id 3489923)1, 2 Bonthron D....Orkin S.H. (Nucleic Acids Res. 1986)
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    105. Construction of cDNA coding for human von Willebrand factor using antibody probes for colony-screening and mapping of the chromosomal gene. (PubMed id 3875078)1, 2 Verweij C.L.... Pannekoek H. (Nucleic Acids Res. 1985)
    106. Human von Willebrand factor (vWF): isolation of complementary DNA (cDNA) clones and chromosomal localization. (PubMed id 3874428)1, 2 Ginsburg D.... Orkin S.H. (Science 1985)
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    108. Laboratory diagnosis and molecular classification of von Willebrand disease. (PubMed id 19506352)1, 9 Gadisseur A....Michiels J.J. (Acta Haematol. 2009)
    109. Variation at the von Willebrand factor (vWF) gene locus is associated with plasma vWF:Ag levels: identification of three novel single nucleotide polymorphisms in the vWF gene promoter. (PubMed id 10361125)4, 9 Keightley A.M....Lillicrap D. (Blood 1999)
    110. Laboratory diagnosis of von Willebrand disease type 1/2E (2A subtype IIE), type 1 Vicenza and mild type 1 caused by mutations in the D3, D4, B1-B3 and C1-C2 domains of the von Willebrand factor gene. Role of von Willebrand factor multimers and the von Willebrand factor propeptide/antigen ratio. (PubMed id 19506359)1, 9 Gadisseur A....Michiels J.J. (Acta Haematol. 2009)
    111. Correlation between von Willebrand factor antigen, von Willebrand factor ristocetin cofactor activity and factor VIII activity in plasma. (PubMed id 17786534)1, 9 Lippi G....Guidi G.C. (J. Thromb. Thrombolysis 2008)
    112. Impact of plasma von Willebrand factor levels in the diagnosis of type 1 von Willebrand disease: results from a multicenter European study (MCMDM-1VWD). (PubMed id 17408405)1, 9 Tosetto A....Peake I. (J. Thromb. Haemost. 2007)
    113. Evidence that differential packaging of the major platelet granule proteins von Willebrand factor and fibrinogen can support their differential release. (PubMed id 17650077)1, 9 Sehgal S. and Storrie B. (J. Thromb. Haemost. 2007)
    114. Ser968Thr mutation within the A3 domain of von Willebrand factor (VWF) in two related patients leads to a defective binding of VWF to collagen. (PubMed id 11583318)1, 9 Ribba A.S....Girma J.P. (Thromb. Haemost. 2001)
    115. Type 1 von Willebrand disease due to reduced von Willebrand factor synthesis and/or survival: observations from a case series. (PubMed id 20303469)1, 9 Casonato A....Pagnan A. (Transl Res 2010)
    116. Recessive von Willebrand disease type 2 Normandy: variable expression of mild hemophilia and VWD type 1. (PubMed id 19506358)1, 9 Michiels J.J....Berneman Z. (Acta Haematol. 2009)
    117. Autosomal dominant C1149R von Willebrand disease: phenotypic findings and their implications. (PubMed id 19286880)1, 9 PAcrez-RodrA-guez A....Batlle J. (Haematologica 2009)
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    119. Assay of the von Willebrand factor (VWF) propeptide to identify patients with type 1 von Willebrand disease with decreased VWF survival. (PubMed id 16835381)1, 9 Haberichter S.L....Montgomery R.R. (Blood 2006)
    120. von Willebrand disease R1374C: type 2A or 2M? A challenge to the revised classification. High frequency in the northwest of Spain (Galicia). (PubMed id 16247740)1, 9 Penas N....Batlle J. (Am. J. Hematol. 2005)
    121. Microsatellite (GT)(n) is part of the von Willebrand factor (VWF) promoter region that influences the glucocorticoid-induced increase in VWF in Cushing's syndrome. (PubMed id 20156642)1, 9 Daidone V....Casonato A. (Thromb. Res. 2010)
    122. Survival of von Willebrand factor released following DDAVP in a type 1 von Willebrand disease cohort: influence of glycosylation, proteolysis and gene mutations. (PubMed id 18449422)1, 9 Millar C.M....van Mourik J.A. (Thromb. Haemost. 2008)
    123. An Arg760Cys mutation in the consensus sequence of the von Willebrand factor propeptide cleavage site is responsible for a new von Willebrand disease variant. (PubMed id 12393698)1, 9 Casonato A....Girolami A. (Blood 2003)
    124. Solid-phase von Willebrand factor contains a conformationally active RGD motif that mediates endothelial cell adhesion through the alpha v beta 3 receptor. (PubMed id 7505120)1, 9 Denis C....Baruch D. (Blood 1993)
    125. Intracellular cotrafficking of factor VIII and von Willebrand factor type 2N variants to storage organelles. (PubMed id 19088379)1, 9 van den Biggelaar M....Mertens K. (Blood 2009)
    126. A novel binding site for ADAMTS13 constitutively exposed on the surface of globular VWF. (PubMed id 19587373)1, 9 Zanardelli S....Lane D.A. (Blood 2009)
    127. Multi-step binding of ADAMTS-13 to von Willebrand factor. (PubMed id 19765212)1, 9 Feys H.B....Sadler J.E. (J. Thromb. Haemost. 2009)
    128. N-linked glycosylation of VWF modulates its interaction with ADAMTS13. (PubMed id 17975018)1, 9 McKinnon T.A....Laffan M.A. (Blood 2008)
    129. Requirements for cellular co-trafficking of factor VIII and von Willebrand factor to Weibel-Palade bodies. (PubMed id 17958741)1, 9 van den Biggelaar M....Mertens K. (J. Thromb. Haemost. 2007)
    130. Rab3D and annexin A2 play a role in regulated secretion of vWF, but not tPA, from endothelial cells. (PubMed id 15257287)1, 9 Knop M....Gerke V. (EMBO J. 2004)
    131. Vasopressin-induced von Willebrand factor secretion from endothelial cells involves V2 receptors and cAMP. (PubMed id 10880054)1, 9 Kaufmann J.E....Vischer U.M. (J. Clin. Invest. 2000)
    132. Proteolytic resistance conferred to fibrinogen by von Willebrand factor. (PubMed id 20024497)1, 9 Tanka-Salamon A....Komorowicz E. (Thromb. Haemost. 2010)
    133. Kynurenines and oxidative status are independently associated with thrombomodulin and von Willebrand factor levels in patients with end-stage renal disease. (PubMed id 19477487)1, 9 Pawlak K....Pawlak D. (Thromb. Res. 2009)
    134. Changes in plasma von Willebrand factor and ADAMTS13 levels associated with left atrial remodeling in atrial fibrillation. (PubMed id 18996572)1, 9 Uemura T....Ogawa H. (Thromb. Res. 2009)
    135. Role of membrane cholesterol in platelet calcium signalling in response to VWF and collagen under stasis and flow. (PubMed id 18521510)1, 9 van Lier M....Heijnen H.F. (Thromb. Haemost. 2008)
    136. High von Willebrand factor levels increase the risk of first ischemic stroke: influence of ADAMTS13, inflammation, and genetic variability. (PubMed id 16990571)1, 9 Bongers T.N....Leebeek F.W. ( a journal of cerebral circulation 2006)
    137. P-selectin binds to the D'-D3 domains of von Willebrand factor in Weibel-Palade bodies. (PubMed id 16418330)1, 9 Michaux G....Cutler D.F. (Blood 2006)
    138. An amino acid polymorphism in von Willebrand factor correlates with increased susceptibility to proteolysis by ADAMTS13. (PubMed id 14525793)1, 9 Bowen D.J. and Collins P.W. (Blood 2004)
    139. Increased levels of endothelial haemostatic markers in patients with coronary heart disease. (PubMed id 11864703)1, 9 Schumacher A....Arnesen H. (Thromb. Res. 2002)
    140. Oxidative modification of von Willebrand factor by neutrophil oxidants inhibits its cleavage by ADAMTS13. (PubMed id 19812385)1, 9 Chen J....LA^pez J.A. (Blood 2010)
    141. [Change of HIF-1alpha protein expression in the placenta bed and concentration of vWF in maternal peripheral blood of pre-eclampsia]. (PubMed id 20197612)1, 9 Peng M....Zhou C. (Zhong Nan Da Xue Xue Bao Yi Xue Ban 2010)
    142. Identification of ADAMTS13 peptide sequences binding to von Willebrand factor. (PubMed id 19944670)1, 9 Moriki T....Murata M. (Biochem. Biophys. Res. Commun. 2010)
    143. Amino acid residues Arg(659), Arg(660), and Tyr(661) in the spacer domain of ADAMTS13 are critical for cleavage of von Willebrand factor. (PubMed id 20075158)1, 9 Jin S.Y....Zheng X.L. (Blood 2010)
    144. Phospholipase D1 is specifically required for regulated secretion of von Willebrand factor from endothelial cells. (PubMed id 18945966)1, 9 Disse J....Gerke V. (Blood 2009)
    145. Shear-induced unfolding activates von Willebrand factor A2 domain for proteolysis. (PubMed id 19817991)1, 9 Baldauf C....GrAoter F. (J. Thromb. Haemost. 2009)
    146. Variations in the ratio between von Willebrand factor and its cleaving protease during systemic inflammation and association with severity and prognosis of organ failure. (PubMed id 19190805)1, 9 Claus R.A....LAPsche W. (Thromb. Haemost. 2009)
    147. ADAMTS13 and von Willebrand factor and the risk of myocardial infarction in men. (PubMed id 17053057)1, 9 Chion C.K....Rosendaal F.R. (Blood 2007)
    148. Shielding of the A1 domain by the D'D3 domains of von Willebrand factor modulates its interaction with platelet glycoprotein Ib-IX-V. (PubMed id 16373331)1, 9 Ulrichts H....Deckmyn H. (J. Biol. Chem. 2006)
    149. Impact of mutations in the von Willebrand factor A2 domain on ADAMTS13-dependent proteolysis. (PubMed id 16322474)1, 9 Hassenpflug W.A....Schneppenheim R. (Blood 2006)
    150. Exosite interactions contribute to tension-induced cleavage of von Willebrand factor by the antithrombotic ADAMTS13 metalloprotease. (PubMed id 17146059)1, 9 Gao W....Sadler J.E. (Proc. Natl. Acad. Sci. U.S.A. 2006)
    151. Type 2N von Willebrand disease due to compound heterozygosity for R854Q and a novel R763G mutation at the cleavage site of von Willebrand factor propeptide. (PubMed id 16953269)1, 9 Hilbert L....Mazurier C. (Thromb. Haemost. 2006)
    152. Bombay phenotype is associated with reduced plasma-VWF levels and an increased susceptibility to ADAMTS13 proteolysis. (PubMed id 15886321)1, 9 O'Donnell J.S....Laffan M.A. (Blood 2005)
    153. Increased soluble intercellular adhesion molecule-1, breast cancer and the acute phase response. (PubMed id 11914659)1, 9 Blann A.D....Baildam A.D. (amp 2002)
    154. Force-induced cleavage of single VWFA1A2A3 tridomains by ADAMTS-13. (PubMed id 19897584)1, 9 Wu T....Zhu C. (Blood 2010)
    155. Leukocyte proteases cleave von Willebrand factor at or near the ADAMTS13 cleavage site. (PubMed id 19541819)1, 9 Raife T.J....Zheng X.L. (Blood 2009)
    156. Levels of von Willebrand factor antigen and von Willebrand factor cleaving protease (ADAMTS13) activity predict clinical events in chronic heart failure. (PubMed id 19718479)1, 9 Gombos T....ProhA!szka Z. (Thromb. Haemost. 2009)
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    158. Increased plasma von Willebrand factor antigen levels but normal von Willebrand factor cleaving protease (ADAMTS13) activity in preeclampsia. (PubMed id 19190814)1, 9 Molvarec A....ProhA!szka Z. (Thromb. Haemost. 2009)
    159. Dominant von Willebrand disease type 2A groups I and II due to missense mutations in the A2 domain of the von Willebrand factor gene: diagnosis and management. (PubMed id 19506362)1, 9 Michiels J.J. and van Vliet H.H. (Acta Haematol. 2009)
    160. Nitric oxide inhibits von Willebrand factor-mediated platelet adhesion and spreading through regulation of integrin alpha(IIb)beta(3) and myosin light chain. (PubMed id 19765213)1, 9 Roberts W....Naseem K.M. (J. Thromb. Haemost. 2009)
    161. Shear-induced interaction of platelets with von Willebrand factor results in glycoprotein Ibalpha shedding. (PubMed id 19820200)1, 9 Cheng H....Dai K. (Am. J. Physiol. Heart Circ. Physiol. 2009)
    162. Valves of the deep venous system: an overlooked risk factor. (PubMed id 19436051)1, 9 Brooks E.G....Bovill E.G. (Blood 2009)
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    164. N1421K mutation in the glycoprotein Ib binding domain impairs ristocetin- and botrocetin-mediated binding of von Willebrand factor to platelets. (PubMed id 18637125)1, 9 Lanke E....Lethagen S. (Eur. J. Haematol. 2008)
    165. Functional impairment of von Willebrand factor in hypertrophic cardiomyopathy: relation to rest and exercise obstruction. (PubMed id 18809794)1, 9 Le Tourneau T....Jude B. (Circulation 2008)
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    167. A common 253-kb deletion involving VWF and TMEM16B in German and Italian patients with severe von Willebrand disease type 3. (PubMed id 17371490)1, 9 Schneppenheim R....Budde U. (J. Thromb. Haemost. 2007)
    168. Effect of von Willebrand disease type 2B and type 2M mutations on the susceptibility of von Willebrand factor to ADAMTS-13. (PubMed id 17087728)1, 9 Rayes J....Girma J.P. (J. Thromb. Haemost. 2007)
    169. Fluvastatin inhibits regulated secretion of endothelial cell von Willebrand factor in response to diverse secretagogues. (PubMed id 17472573)1, 9 Fish R.J....Kruithof E.K. (Biochem. J. 2007)
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    336. High VWF, low ADAMTS13, and oral contraceptives increase the risk of ischemic stroke and myocardial infarction in young women. (PubMed id 22110247)1 Andersson H.M....Rosendaal F.R. (Blood 2012)
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    358. HIV-1 and recombinant gp120 affect the survival and differentiation of human vessel wall-derived mesenchymal stem cells. (PubMed id 21612582)1 Gibellini D....Re M.C. (Retrovirology 2011)
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    432. Are integrin alpha(2)beta(1), glycoprotein Ib and vWf levels correlated with their contributions to platelet adhesion on collagen under high-shear flow? (PubMed id 20063990)1 Jung S.M....Moroi M. (Platelets 2010)
    433. Sources of variation in factor VIII, von Willebrand factor and fibrinogen measurements: implications for detecting deficiencies and increased plasma levels. (PubMed id 20627205)1 Bach J....Hellstern P. (Thromb. Res. 2010)
    434. An autoantibody epitope comprising residues R660, Y661, and Y665 in the ADAMTS13 spacer domain identifies a binding site for the A2 domain of VWF. (PubMed id 20032502)1 Pos W....Luken B.M. (Blood 2010)
    435. Premature termination codon mutations in the von Willebrand factor gene are associated with allele-specific and position-dependent mRNA decay. (PubMed id 19773258)1 PlatA" M....Asselta R. (Haematologica 2010)
    436. Baseline von Willebrand factor plasma levels and no-reflow phenomenon after primary percutaneous coronary intervention for ST segment elevation myocardial infarction. (PubMed id 19732980)1 Sgueglia G.A....Crea F. (Int. J. Cardiol. 2010)
    437. Abnormal VWF modifies megakaryocytopoiesis: studies of platelets and megakaryocyte cultures from patients with von Willebrand disease type 2B. (PubMed id 20118404)1 Nurden P....Federici A.B. (Blood 2010)
    438. von Willebrand factor clearance does not involve proteolysis by ADAMTS-13. (PubMed id 20704649)1 Badirou I....Denis C.V. (J. Thromb. Haemost. 2010)
    439. Homozygous typeA 2N R854W von Willebrand factor is poorly secreted and causes a severe von Willebrand disease phenotype. (PubMed id 20586924)1 Castaman G....Schneppenheim R. (J. Thromb. Haemost. 2010)
    440. The plasma von Willebrand factor O-glycome comprises a surprising variety of structures including ABH antigens and disialosyl motifs. (PubMed id 19874459)1 Canis K....Dell A. (J. Thromb. Haemost. 2010)
    441. Disulfide bond reduction of von Willebrand factor by ADAMTS-13. (PubMed id 20946172)1 Yeh H.C....Dong J.F. (J. Thromb. Haemost. 2010)
    442. An integrative method for scoring candidate genes from association studies: application to warfarin dosing. (PubMed id 21044367)1 Tatonetti N.P....Altman R.B. (BMC Bioinformatics 2010)
    443. The importance of vicinal cysteines, C1669 and C1670, for von Willebrand factor A2 domain function. (PubMed id 20354169)1 Luken B.M....Crawley J.T. (Blood 2010)
    444. Alterations of mRNA processing and stability as a pathogenic mechanism in von Willebrand factor quantitative deficiencies. (PubMed id 20854374)1 Castaman G....Duga S. (J. Thromb. Haemost. 2010)
    445. The mutation N528S in the von Willebrand factor (VWF) propeptide causes defective multimerization and storage of VWF. (PubMed id 20335223)1 Haberichter S.L....Schneppenheim R. (Blood 2010)
    446. [Impact of vWF gene A1381T polymorphism and ABO blood group on von Willebrand factor level in plasma]. (PubMed id 20723310)1 Yuan Z.H....Zhu P. (Zhongguo Shi Yan Xue Ye Xue Za Zhi 2010)
    447. Destabilization of the A1 domain in von Willebrand factor dissociates the A1A2A3 tri-domain and provokes spontaneous binding to glycoprotein Ibalpha and platelet activation under shear stress. (PubMed id 20498367)1 Auton M....Cruz M.A. (J. Biol. Chem. 2010)
    448. Validation of a rapid test (VWF-LIA) for the quantitative determination of von Willebrand factor antigen in type 1 von Willebrand disease diagnosis within the European multicenter study MCMDM-1VWD. (PubMed id 20650506)1 Castaman G....Rodeghiero F. (Thromb. Res. 2010)
    449. Comparative study of coagulation and thrombin generation in the portal and jugular plasma of patients with cirrhosis. (PubMed id 20806106)1 Delahousse B....Gruel Y. (Thromb. Haemost. 2010)
    450. A human MAP kinase interactome. (PubMed id 20936779)1 Bandyopadhyay S....Ideker T. (Nat. Methods 2010)
    451. mRNA levels of CD31, CD144, CD146 and von Willebrand factor do not serve as surrogate markers for circulating endothelial cells. (PubMed id 20589320)1 Strijbos M.H....Lamers C.H. (Thromb. Haemost. 2010)
    452. A cluster of mutations in the D3 domain of von Willebrand factor correlates with a distinct subgroup of von Willebrand disease: type 2A/IIE. (PubMed id 20351307)1 Schneppenheim R....Budde U. (Blood 2010)
    453. Relevance of chloride binding to von Willebrand factor in type 2B von Willebrand disease patients. (PubMed id 19943880)1 Baronciani L....de Cristofaro R. (J. Thromb. Haemost. 2010)
    454. Functional characterization of a 13-bp deletion (c.-1522_-1510del13) in the promoter of the von Willebrand factor gene in type 1 von Willebrand disease. (PubMed id 20696945)1 Othman M....Lillicrap D. (Blood 2010)
    455. Thrombospondin-1 and ADAMTS13 competitively bind to VWF A2 and A3 domains in vitro. (PubMed id 20705333)1 Wang A....Ruan C. (Thromb. Res. 2010)
    456. Neuropeptide delivery to the brain: a von Willebrand factor signal peptide to direct neuropeptide secretion. (PubMed id 20701764)1 de Backer M.W....Adan R.A. (BMC Neurosci 2010)
    457. A novel alanine or threonine 789 to proline mutation causing type 2N von Willebrand's disease when inherited homozygously or heterozygously with arginine 854 to glutamine mutation. (PubMed id 20491956)1 Enayat M.S....Hill F.G. (Haemophilia 2010)
    458. Rapid activation of endothelial cells enables Plasmodium falciparum adhesion to platelet-decorated von Willebrand factor strings. (PubMed id 19897581)1 Bridges D.J....Craig A. (Blood 2010)
    459. Novel associations of multiple genetic loci with plasma levels of factor VII, factor VIII, and von Willebrand factor: The CHARGE (Cohorts for Heart and Aging Research in Genome Epidemiology) Consortium. (PubMed id 20231535)1 Smith N.L....O'Donnell C.J. (Circulation 2010)
    460. A novel deletion mutation is recurrent in von Willebrand disease types 1 and 3. (PubMed id 19372260)1 Sutherland M.S....Keeney S. (Blood 2009)
    461. Genetic alteration of the D2 domain abolishes von Willebrand factor multimerization and trafficking into storage. (PubMed id 19192112)1 Haberichter S.L....Gill J.C. (J. Thromb. Haemost. 2009)
    462. A novel type 2A von Willebrand factor mutation (V1499E) associated with variable clinical expression. (PubMed id 19346881)1 van den Heuvel E....Versteegh F.G. (J. Pediatr. Hematol. Oncol. 2009)
    463. ADAMTS13 bound to endothelial cells exhibits enhanced cleavage of von Willebrand factor. (PubMed id 19729451)1 Vomund A.N. and Majerus E.M. (J. Biol. Chem. 2009)
    464. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (Am. J. Hum. Genet. 2009)
    465. Structural specializations of A2, a force-sensing domain in the ultralarge vascular protein von Willebrand factor. (PubMed id 19470641)1 Zhang Q....Springer T.A. (Proc. Natl. Acad. Sci. U.S.A. 2009)
    466. Heyde's syndrome without a decrease in large von Willebrand factor multimers: a case of intestinal bleedings reversed by valve replacement in a patient with aortic stenosis. (PubMed id 19350125)1 Undas A....Sadowski J. (Thromb. Haemost. 2009)
    467. Platelet morphological changes in 2 patients with von Willebrand disease type 3 caused by large homozygous deletions of the von Willebrand factor gene. (PubMed id 19608674)1 Nurden P....Federici A.B. (Haematologica 2009)
    468. ADAMTS-13 cleaves long von Willebrand factor multimeric strings anchored to endothelial cells in the absence of flow, platelets or conformation-altering chemicals. (PubMed id 18983500)1 Turner N....Moake J. (J. Thromb. Haemost. 2009)
    469. Fluid shear induces conformation change in human blood protein von Willebrand factor in solution. (PubMed id 19289057)1 Singh I....Neelamegham S. (Biophys. J. 2009)
    470. Expression of 14 von Willebrand factor mutations identified in patients with type 1 von Willebrand disease from the MCMDM-1VWD study. (PubMed id 19566550)1 Eikenboom J....Goodeve A. (J. Thromb. Haemost. 2009)
    471. [Polymorphism of DXS15, CA13, CA22 loci in Guangdong normal population]. (PubMed id 20030949)1 Chu Y.X....Yu C.S. (Zhongguo Shi Yan Xue Ye Xue Za Zhi 2009)
    472. Kinetic study of von Willebrand factor self-aggregation induced by ristocetin. (PubMed id 19647361)1 Di Stasio E....De Cristofaro R. (Biophys. Chem. 2009)
    473. A +220 GATA motif mediates basal but not endotoxin-repressible expression of the von Willebrand factor promoter in Hprt-targeted transgenic mice. (PubMed id 19496923)1 Liu J....Aird W.C. (J. Thromb. Haemost. 2009)
    474. Type 2A (IIH) von Willebrand disease is due to mutations that affect von Willebrand factor multimerization. (PubMed id 19422453)1 Baronciani L....Mannucci P.M. (J. Thromb. Haemost. 2009)
    475. Large-scale proteomics and phosphoproteomics of urinary exosomes. (PubMed id 19056867)1 Gonzales P.A....Knepper M.A. (J. Am. Soc. Nephrol. 2009)
    476. von Willebrand factor cleaved from endothelial cells by ADAMTS13 remains ultralarge in size. (PubMed id 19682236)1 Jin S.Y....Zheng X.L. (J. Thromb. Haemost. 2009)
    477. Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. (PubMed id 19159218)2 Chen R.... Zou H. (J. Proteome Res. 2009)
    478. Novel missense mutation c.2685G&gt;C (p.Q895H) in VWF gene associated with very low levels of VWF mRNA. (PubMed id 18712522)1 Cabrera N....Aznar J.A. (Ann. Hematol. 2009)
    479. Dominant von Willebrand disease type 2M and 2U are variable expressions of one distinct disease entity caused by loss-of-function mutations in the A1 domain of the von Willebrand factor gene. (PubMed id 19506361)1 Gadisseur A....Michiels J.J. (Acta Haematol. 2009)
    480. von Willebrand factor assembly and secretion. (PubMed id 19630761)1 Sadler J.E. (J. Thromb. Haemost. 2009)
    481. N-Glycans of ADAMTS13 modulate its secretion and von Willebrand factor cleaving activity. (PubMed id 18981290)1 Zhou W. and Tsai H.M. (Blood 2009)
    482. Inflammation, hemostasis, and the risk of kidney function decline in the Atherosclerosis Risk in Communities (ARIC) Study. (PubMed id 19110358)1 Bash L.D....Astor B.C. (Am. J. Kidney Dis. 2009)
    483. Laboratory diagnosis and molecular basis of mild von Willebrand disease type 1. (PubMed id 19506353)1 Michiels J.J....van Vliet H.H. (Acta Haematol. 2009)
    484. Rapid molecular diagnosis of von Willebrand disease by direct sequencing. Detection of 12 novel putative mutations in VWF gene. (PubMed id 19277422)1 Corrales I....Vidal F. (Thromb. Haemost. 2009)
    485. Autosomal recessive von Willebrand disease type 1 or 2 due to homozygous or compound heterozygous mutations in the von Willebrand factor gene. A single center experience on molecular heterogeneity and laboratory features in 12 families. (PubMed id 19506356)1 Castaman G....Rodeghiero F. (Acta Haematol. 2009)
    486. A strategy for precise and large scale identification of core fucosylated glycoproteins. (PubMed id 19139490)2 Jia W.... Qian X.H. (Mol. Cell. Proteomics 2009)
    487. Impaired glucose tolerance and endothelial damage, as assessed by levels of von Willebrand factor and circulating endothelial cells, following acute myocardial infarction. (PubMed id 20021313)1 Jessani S.S....Lip G.Y. (Ann. Med. 2009)
    488. Genetic analysis of Alzheimer's disease in the Uppsala Longitudinal Study of Adult Men. (PubMed id 19141999)4 Giedraitis V....Glaser A. (Dement Geriatr Cogn Disord 2009)
    489. Altered megakaryocytopoiesis in von Willebrand type 2B disease. (PubMed id 19630816)1 Nurden A.T....Nurden P. (J. Thromb. Haemost. 2009)
    490. An Alu-mediated novel large deletion is the most frequent cause of type 3 von Willebrand disease in Hungary. (PubMed id 18665926)1 Mohl A....Schneppenheim R. (J. Thromb. Haemost. 2008)
    491. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)
    492. Characterization of a novel mutation in the von Willebrand factor propeptide in a distinct subtype of recessive von Willebrand disease. (PubMed id 18690339)1 Lanke E....Lethagen S. (Thromb. Haemost. 2008)
    493. Platelet-VWF complexes are preferred substrates of ADAMTS13 under fluid shear stress. (PubMed id 17901248)1 Shim K....Sadler J.E. (Blood 2008)
    494. Effects of von Willebrand factor concentration and platelet collision on shear-induced platelet activation. (PubMed id 18612539)1 Gao Z....Ruan C. (Thromb. Haemost. 2008)
    495. Type 2B von Willebrand disease associated with the release of platelet agglutinates from megakaryocytes in the bone marrow. (PubMed id 18776767)1 Slayton W.B....Friedman K.D. (J. Pediatr. Hematol. Oncol. 2008)
    496. Relationship between von Willebrand factor, cholesterol and triglycerides in non-diabetic subjects. (PubMed id 18042361)1 Lippi G....Franchini M. (Nutr Metab Cardiovasc Dis 2008)
    497. Aquaporin 2 gene variations, risk of venous thrombosis and plasma levels of von Willebrand factor and factor VIII. (PubMed id 18515885)1 Nossent A.Y....Eikenboom J.C. (Haematologica 2008)
    498. Magnesium maintains endothelial integrity, up-regulates proteolysis of ultra-large von Willebrand factor, and reduces platelet aggregation under flow conditions. (PubMed id 18327408)1 Dong J.F....Kent T.A. (Thromb. Haemost. 2008)
    499. Global analysis of host-pathogen interactions that regulate early-stage HIV-1 replication. (PubMed id 18854154)1 KAPnig R....Chanda S.K. (Cell 2008)
    500. Prevalence of type 2b 'MalmAP/New York' von Willebrand disease in Italy: the role of von Willebrand factor gene conversion. (PubMed id 18315546)1 Baronciani L....Mannucci P.M. (J. Thromb. Haemost. 2008)
    501. Inflammatory cytokines inhibit ADAMTS13 synthesis in hepatic stellate cells and endothelial cells. (PubMed id 18433458)1 Cao W.J....Zheng X.L. (J. Thromb. Haemost. 2008)
    502. Prothrombotic gene variation in patients with large and small vessel disease. (PubMed id 18622144)4 Pruissen D.M....Algra A. (Neuroepidemiology 2008)
    503. Persistent factor VIII-dependent factor X activation on endothelial cells is independent of von Willebrand factor. (PubMed id 18388497)1 Brinkman H.J....Mertens K. (amp 2008)
    504. Basal secretion of von Willebrand factor from human endothelial cells. (PubMed id 18344423)1 Giblin J.P....Hannah M.J. (Blood 2008)
    505. Hepatitis C virus infection protein network. (PubMed id 18985028)1 de Chassey B....Lotteau V. (Mol. Syst. Biol. 2008)
    506. Antihemostatic activity of human granzyme B mediated by cleavage of von Willebrand factor. (PubMed id 18577516)1 Buzza M.S....Bird P.I. (J. Biol. Chem. 2008)
    507. Thrombospondin-1 in von Willebrand factor function. (PubMed id 18855616)1 Bonnefoy A. and Hoylaerts M.F. (Curr Drug Targets 2008)
    508. Beta3 integrin haplotype influences gene regulation and plasma von Willebrand factor activity. (PubMed id 18045606)1 Payne K.E....Carter A.M. (Atherosclerosis 2008)
    509. Influence of a GT repeat element on shear stress responsiveness of the VWF gene promoter. (PubMed id 18485092)1 Hough C....Lillicrap D. (J. Thromb. Haemost. 2008)
    510. Extracellular control of VWF multimer size and thiol-disulfide exchange. (PubMed id 18503632)1 Luken B.M. (J. Thromb. Haemost. 2008)
    511. The effect of exercise on von Willebrand factor and ADAMTS-13 in individuals with type 1 and type 2B von Willebrand disease. (PubMed id 17922807)1 Stakiw J....James P. (J. Thromb. Haemost. 2008)
    512. von Willebrand factor: evidence for variable clearance in vivo according to Y/C1584 phenotype and ABO blood group. (PubMed id 17949477)1 Davies J.A....Bowen D.J. (J. Thromb. Haemost. 2008)
    513. Is VWF R924Q a benign polymorphism, a marker of a null allele or a factor VIII-binding defect? The debate continues with results from the UKHCDO VWD study. (PubMed id 18841300)1 Lester W....Collins P. (Thromb. Haemost. 2008)
    514. Hemostatic and inflammatory risk factors for intracerebral hemorrhage in a pooled cohort. (PubMed id 18535282)1 Sturgeon J.D....Cushman M. ( a journal of cerebral circulation 2008)
    515. The membrane-proximal intermolecular disulfide bonds in glycoprotein Ib influence receptor binding to von Willebrand factor. (PubMed id 18647229)1 Mo X....Li R. (J. Thromb. Haemost. 2008)
    516. Evidence that high von Willebrand factor and low ADAMTS-13 levels independently increase the risk of a non-fatal heart attack. (PubMed id 18194418)1 Crawley J.T....Lowe G.D. (J. Thromb. Haemost. 2008)
    517. Type 2B von Willebrand disease in seven individuals from three different families: phenotypic and genotypic characterization. (PubMed id 17598021)1 SzA!ntA^ T....Vanhoorelbeke K. (Thromb. Haemost. 2007)
    518. Platelet activation and von Willebrand factor binding to platelets in newborn infants with central venous lines. (PubMed id 17159336)1 Schmugge M....Rand M.L. (Acta Haematol. 2007)
    519. Effects of toll-like receptor-4 gene polymorphisms on soluble P-selectin and von Willebrand factor levels in hypercholesterolemic patients. (PubMed id 17849054)1 Di Nisio M....Porreca E. (Thromb. Haemost. 2007)
    520. Surface-dependent expression in the platelet GPIb binding domain within human von Willebrand factor studied by atomic force microscopy. (PubMed id 17010412)1 Kang I....Marchant R.E. (Thromb. Res. 2007)
    521. Investigation of von Willebrand factor gene mutations in Korean von Willebrand disease patients. (PubMed id 18094571)1 Song J....Song K.S. (Korean J Lab Med 2007)
    522. Characterization of the interaction between von Willebrand factor and osteoprotegerin. (PubMed id 17723135)1 Shahbazi S....Christophe O.D. (J. Thromb. Haemost. 2007)
    523. Autosomal recessive von Willebrand disease associated with compound heterozygosity for a novel nonsense mutation (2908 del C) and the missense mutation C2362F: definite evidence for the non-penetrance of the C2362F mutation. (PubMed id 17109387)1 Castaman G....Rodeghiero F. (Am. J. Hematol. 2007)
    524. Efficiency of von Willebrand factor-mediated targeting of interleukin-8 into Weibel-Palade bodies. (PubMed id 17883593)1 Bierings R....van Mourik J.A. (J. Thromb. Haemost. 2007)
    525. A mechanism to safeguard platelet adhesion under high shear flow: von Willebrand factor-glycoprotein Ib and integrin alphabeta-collagen interactions make complementary, collagen-type-specific contributions to adhesion. (PubMed id 17408410)1 Moroi M. and Jung S.M. (J. Thromb. Haemost. 2007)
    526. Von Willebrand disease - phenotype versus genotype: deficiency versus disease. (PubMed id 17490730)1 Lillicrap D. (Thromb. Res. 2007)
    527. Von Willebrand factor: looking back and looking forward. (PubMed id 17597991)1 Ruggeri Z.M. (Thromb. Haemost. 2007)
    528. Haemostatic changes and acquired activated protein C resistance in normal pregnancy. (PubMed id 17890957)1 Mahieu B....Van der Planken M. (amp 2007)
    529. The mutational spectrum of type 1 von Willebrand disease: Results from a Canadian cohort study. (PubMed id 17190853)1 James P.D....Lillicrap D. (Blood 2007)
    530. Soluble plasma-derived von Willebrand factor assembles to a haemostatically active filamentous network. (PubMed id 17393012)1 Barg A....Schneider S.W. (Thromb. Haemost. 2007)
    531. A role for von Willebrand factor in Streptococcus sanguis-induced platelet activation. (PubMed id 18064343)1 McNicol A....Israels S.J. (Thromb. Haemost. 2007)
    532. Von Willebrand factor short sequence repeat locus 2 (intron 40) consists of three polymorphic subloci. (PubMed id 17159339)1 Othman M....O'Shaughnessy D.F. (Acta Haematol. 2007)
    533. Microfluidic reveals generation of platelet-strings on tumor-activated endothelium. (PubMed id 17721608)1 Goerge T....Schneider S.W. (Thromb. Haemost. 2007)
    534. Plasma intercellular adhesion molecule-1 and von Willebrand factor in primary graft dysfunction after lung transplantation. (PubMed id 17908278)1 Covarrubias M....Christie J.D. (Am. J. Transplant. 2007)
    535. Impaired dimerization of von Willebrand factor subunit due to mutation A2801D in the CK domain results in a recessive type 2A subtype IID von Willebrand disease. (PubMed id 16676067)1 Hommais A....Ribba A.S. (Thromb. Haemost. 2006)
    536. Solution structure of human von Willebrand factor studied using small angle neutron scattering. (PubMed id 17052980)1 Singh I....Neelamegham S. (J. Biol. Chem. 2006)
    537. ADAMTS13 substrate recognition of von Willebrand factor A2 domain. (PubMed id 16221672)1 Zanardelli S....Lane D.A. (J. Biol. Chem. 2006)
    538. The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (Science 2006)
    539. The finished DNA sequence of human chromosome 12. (PubMed id 16541075)2 Scherer S.E.... Gibbs R.A. (Nature 2006)
    540. Molecular mapping of the chloride-binding site in von Willebrand factor (VWF): energetics and conformational effects on the VWF/ADAMTS-13 interaction. (PubMed id 16899464)1 De Cristofaro R....Mannucci P.M. (J. Biol. Chem. 2006)
    541. A single high-affinity binding site for von Willebrand factor in collagen III, identified using synthetic triple-helical peptides. (PubMed id 16912226)1 Lisman T....Farndale R.W. (Blood 2006)
    542. The interaction of von Willebrand factor-A1 domain with collagen: mutation G1324S (type 2M von Willebrand disease) impairs the conformational change in A1 domain induced by collagen. (PubMed id 16420575)1 Morales L.D....Cruz M.A. (J. Thromb. Haemost. 2006)
    543. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    544. p130Cas: a versatile scaffold in signaling networks. (PubMed id 16581250)1 Defilippi P....Cabodi S. (Trends Cell Biol. 2006)
    545. Mutations C1157F and C1234W of von Willebrand factor cause intracellular retention with defective multimerization and secretion. (PubMed id 16409464)1 Hommais A....Ribba A.S. (J. Thromb. Haemost. 2006)
    546. Impact of fibronectin assembly on platelet thrombus formation in response to type I collagen and von Willebrand factor. (PubMed id 16735600)1 Cho J. and Mosher D.F. (Blood 2006)
    547. R924Q substitution encoded within exon 21 of the von Willebrand factor gene related to mild bleeding phenotype. (PubMed id 16894469)1 Casais P....Lazzari M.A. (Thromb. Haemost. 2006)
    548. Physical stress as a model to study variations in ADAMTS-13 activity, von Willebrand factor level and platelet activation. (PubMed id 16634765)1 Claus R.A....Hilberg T. (J. Thromb. Haemost. 2006)
    549. Usefulness of von Willebrand factor in cardiac allograft vasculopathy: preliminary experience. (PubMed id 17098004)1 Chamorro C.I....Salvador A. (Transplant. Proc. 2006)
    550. Paratope determination of the antithrombotic antibody 82D6A3 based on the crystal structure of its complex with the von Willebrand factor A3-domain. (PubMed id 16314412)1 Staelens S....Deckmyn H. (J. Biol. Chem. 2006)
    551. Recombinant factor VIII and factor VIII-von Willebrand factor complex do not present danger signals for human dendritic cells. (PubMed id 16953272)1 Pfistershammer K....Reipert B.M. (Thromb. Haemost. 2006)
    552. Dynamic force spectroscopy of glycoprotein Ib-IX and von Willebrand factor. (PubMed id 15764659)1 Arya M....Anvari B. (Biophys. J. 2005)
    553. Theoretical structural explanation for Group I and Group II, type 2A von Willebrand disease mutations. (PubMed id 15842374)1 O'Brien L.A....Lillicrap D. (J. Thromb. Haemost. 2005)
    554. A tripeptide mimetic of von Willebrand factor residues 981-983 enhances platelet adhesion to fibrinogen by signaling through integrin alpha(IIb)beta3. (PubMed id 15946218)1 Litjens P.E....Akkerman J.W. (J. Thromb. Haemost. 2005)
    555. Cleavage of ultra-large von Willebrand factor by ADAMTS-13 under flow conditions. (PubMed id 16102037)1 Dong J.F. (J. Thromb. Haemost. 2005)
    556. Platelets adhered to endothelial cell-bound ultra-large von Willebrand factor strings support leukocyte tethering and rolling under high shear stress. (PubMed id 15748247)1 Bernardo A....Dong J.F. (J. Thromb. Haemost. 2005)
    557. Plasma von Willebrand factor antigen levels in non-small cell lung cancer patients. (PubMed id 15816602)1 Martini F....Roselli M. (Anticancer Res. 2005)
    558. Enzymatically active ADAMTS13 variants are not inhibited by anti-ADAMTS13 autoantibodies: a novel therapeutic strategy? (PubMed id 16203734)1 Zhou W....Tsai H.M. (J. Biol. Chem. 2005)
    559. Re-establishment of VWF-dependent Weibel-Palade bodies in VWD endothelial cells. (PubMed id 15331450)1 Haberichter S.L....Montgomery R.R. (Blood 2005)
    560. Decreased plasma concentration of von Willebrand factor antigen (VWF:Ag) in patients with glycogen storage disease type Ia. (PubMed id 16435187)1 MA1hlhausen C....Santer R. (J. Inherit. Metab. Dis. 2005)
    561. Evaluation of the von Willebrand factor Y1584C polymorphism as a potential risk factor for bleeding in patients receiving anticoagulant treatment with vitamin K antagonists. (PubMed id 15842375)1 Tjernberg P....Reitsma P.H. (J. Thromb. Haemost. 2005)
    562. Endothelial microparticles induce formation of platelet aggregates via a von Willebrand factor/ristocetin dependent pathway, rendering them resistant to dissociation. (PubMed id 15946221)1 Jy W....Ahn Y.S. (J. Thromb. Haemost. 2005)
    563. Recombinant CUB-1 domain polypeptide inhibits the cleavage of ULVWF strings by ADAMTS13 under flow conditions. (PubMed id 16141351)1 Tao Z....Dong J.F. (Blood 2005)
    564. Differential kinetics of cell surface loss of von Willebrand factor and its propolypeptide after secretion from Weibel-Palade bodies in living human endothelial cells. (PubMed id 15831502)1 Hannah M.J....Carter T. (J. Biol. Chem. 2005)
    565. The von Willebrand factor self-association is modulated by a multiple domain interaction. (PubMed id 15748246)1 Ulrichts H....Deckmyn H. (J. Thromb. Haemost. 2005)
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    568. The proximal carboxyl-terminal domains of ADAMTS13 determine substrate specificity and are all required for cleavage of von Willebrand factor. (PubMed id 15975930)1 Ai J....Zheng X.L. (J. Biol. Chem. 2005)
    569. Gain of von Willebrand factor-binding function by mutagenesis of a species-conserved residue within the leucine-rich repeat region of platelet glycoprotein Ibalpha. (PubMed id 15933060)1 Peng Y....LA^pez J.A. (Blood 2005)
    570. The prevalence of the cysteine1584 variant of von Willebrand factor is increased in type 1 von Willebrand disease: co-segregation with increased susceptibility to ADAMTS13 proteolysis but not clinical phenotype. (PubMed id 15755288)2 Bowen D.J.... Hill F.G. (Br. J. Haematol. 2005)
    571. Integrins and Src: dynamic duo of adhesion signaling. (PubMed id 16005629)1 Shattil S.J. (Trends Cell Biol. 2005)
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    574. Von Willebrand factor present in fibrillar collagen enhances platelet adhesion to collagen and collagen-induced platelet aggregation. (PubMed id 15102023)1 Bernardo A....Dong J.F. (J. Thromb. Haemost. 2004)
    575. The human plasma proteome: a nonredundant list developed by combination of four separate sources. (PubMed id 14718574)1 Anderson N.L....Lobley A. (amp 2004)
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    577. P-selectin anchors newly released ultralarge von Willebrand factor multimers to the endothelial cell surface. (PubMed id 14630802)1 Padilla A....Dong J.F. (Blood 2004)
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    580. Fibrin polymerization is crucial for thrombin generation in platelet-rich plasma in a VWF-GPIb-dependent process, defective in Bernard-Soulier syndrome. (PubMed id 14717981)1 BAcguin S....Hemker H.C. (J. Thromb. Haemost. 2004)
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    582. A novel type 2A von Willebrand factor mutation located at the last nucleotide of exon 26 (3538G&gt;A) causes skipping of 2 nonadjacent exons. (PubMed id 15226181)1 James P.D....Lillicrap D. (Blood 2004)
    583. Surface-exposed hemophilic mutations across the factor VIII C2 domain have variable effects on stability and binding activities. (PubMed id 15471879)1 Spiegel P.C....Stoddard B.L. (J. Biol. Chem. 2004)
    584. VWF73, a region from D1596 to R1668 of von Willebrand factor, provides a minimal substrate for ADAMTS-13. (PubMed id 14512308)1 Kokame K....Miyata T. (Blood 2004)
    585. Molecular modeling of the von Willebrand factor A2 Domain and the effects of associated type 2A von Willebrand disease mutations. (PubMed id 15322948)1 Sutherland J.J....Weaver D.F. (J Mol Model 2004)
    586. Crystal structure of the von Willebrand factor A domain of human capillary morphogenesis protein 2: an anthrax toxin receptor. (PubMed id 15079089)1 Lacy D.B.... Collier R.J. (Proc. Natl. Acad. Sci. U.S.A. 2004)
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    592. Collagen-binding mode of vWF-A3 domain determined by a transferred cross-saturation experiment. (PubMed id 12447349)1 Nishida N....Shimada I. (Nat. Struct. Biol. 2003)
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    594. Mural thrombus generation in type 2A and 2B von Willebrand disease under flow conditions. (PubMed id 12393671)1 Sugimoto M....Yoshioka A. (Blood 2003)
    595. Intercellular calcium communication regulates platelet aggregation and thrombus growth. (PubMed id 12668663)1 Nesbitt W.S....Jackson S.P. (J. Cell Biol. 2003)
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    600. Critical roles for the COOH-terminal NITY and RGT sequences of the integrin beta3 cytoplasmic domain in inside-out and outside-in signaling. (PubMed id 12860973)1 Xi X....Du X. (J. Cell Biol. 2003)
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    699. 2B or not 2B? Disparate discrimination of functional VWF discordance using different assay panels or methodologies may lead to success or failure in the early identification of type 2B VWD. (PubMed id 17721617)9 Favaloro E.J....Marsden K. (Thromb. Haemost. 2007)
    700. Classification and characterization of hereditary types 2A, 2B, 2C, 2D, 2E, 2M, 2N, and 2U (unclassifiable) von Willebrand disease. (PubMed id 17000885)9 Michiels J.J....van Vliet H. (Clin. Appl. Thromb. Hemost. 2006)
    701. Measurement of von Willebrand factor activity: relative effects of ABO blood type and race. (PubMed id 14521604)9 Miller C.H....Evatt B. (J. Thromb. Haemost. 2003)
    702. Critical independent regions in the VWF propeptide and mature VWF that enable normal VWF storage. (PubMed id 12393513)9 Haberichter S.L....Montgomery R.R. (Blood 2003)
    703. Comparative study on collagen-binding enzyme-linked immunosorbent assay and ristocetin cofactor activity assays for detection of functional activity of von Willebrand factor. (PubMed id 11992238)9 Turecek P.L....Schwarz H.P. (Semin. Thromb. Hemost. 2002)
    704. Discrimination of von Willebrands disease (VWD) subtypes: direct comparison of von Willebrand factor:collagen binding assay (VWF:CBA) with monoclonal antibody (MAB) based VWF-capture systems. (PubMed id 11057847)9 Favaloro E.J....Hertzberg M. (Thromb. Haemost. 2000)
    705. von Willebrand factor: measuring its antigen or function? Correlation between the level of antigen, activity, and multimer size using various detection systems. (PubMed id 9700852)9 Fischer B.E....Dorner F. (Thromb. Res. 1998)
    706. Collagen covalently immobilized onto plastic surfaces simplifies measurement of von Willebrand factor-collagen binding activity. (PubMed id 9619734)9 Fischer B.E....Dorner F. (Ann. Hematol. 1998)
    707. Binding of the von Willebrand factor A1 domain to histone. (PubMed id 9219327)9 Ward C.M....Berndt M.C. (Thromb. Res. 1997)
    708. Involvement of calcium and G proteins in the acute release of tissue-type plasminogen activator and von Willebrand factor from cultured human endothelial cells. (PubMed id 9351387)9 van den Eijnden-Schrauwen Y....Emeis J.J. (Arterioscler. Thromb. Vasc. Biol. 1997)
    709. Von Willebrand factor abnormalities in IgA nephropathy. (PubMed id 9075127)9 Bertaglia G....Gambaro G. (Nephrol. Dial. Transplant. 1997)
    710. Clearance of normal and type 2A von Willebrand factor in the rat. (PubMed id 8781425)9 Stoddart J.H....Lynch D.C. (Blood 1996)
    711. Relatively increased von Willebrand factor activity after off-pump coronary artery bypass graft surgery. (PubMed id 17200766)9 Lo B....Fijnheer R. (Thromb. Haemost. 2007)
    712. von Willebrand factor and its propeptide: the influence of secretion and clearance on protein levels and the risk of venous thrombosis. (PubMed id 17059421)9 Nossent A.Y....Eikenboom H.C. (J. Thromb. Haemost. 2006)
    713. Correction of a murine model of von Willebrand disease by gene transfer. (PubMed id 16638935)9 Pergolizzi R.G....Crystal R.G. (Blood 2006)
    714. Comparative analysis and classification of von Willebrand factor/factor VIII concentrates: impact on treatment of patients with von Willebrand disease. (PubMed id 16977573)9 Budde U....MA1ller H.G. (Semin. Thromb. Hemost. 2006)
    715. In vitro studies, pharmacokinetic studies and clinical use of a high purity double virus inactivated FVIII/VWF concentrate (Immunate) in the treatment of von Willebrand disease. (PubMed id 15213847)9 Ver Elst K.M....Leebeek F.W. (Thromb. Haemost. 2004)
    716. A comparative in vitro evaluation of six von Willebrand factor concentrates. (PubMed id 15086321)9 Lethagen S....Hillarp A. (Haemophilia 2004)
    717. Use of the collagen-binding assay for von Willebrand factor in the analysis of type 2M von Willebrand disease: a comparison with the ristocetin cofactor assay. (PubMed id 11841416)9 Riddell A.F....Brown S.A. (Br. J. Haematol. 2002)
    718. Standardisation of von Willebrand Factor in therapeutic concentrates: calibration of the 1st International Standard for von Willebrand Factor concentrate (00/514). (PubMed id 12353064)9 Hubbard A.R....Mazurier C. (Thromb. Haemost. 2002)
    719. Mapping and functional studies of two alloantibodies developed in patients with type 3 von Willebrand disease. (PubMed id 10739386)9 Tout H....Girma J.P. (Thromb. Haemost. 2000)
    720. Von Willebrand factor: molecular size and functional activity. (PubMed id 8767102)9 Furlan M. (Ann. Hematol. 1996)
    721. Purification and characterization of human platelet von Willebrand factor. (PubMed id 7819071)9 Williams S.B....Gralnick H.R. (Br. J. Haematol. 1994)
    722. Role of von Willebrand factor in vascular disease. (PubMed id 19151843)9 Paulinska P....Jilma B. (Hamostaseologie 2009)
    723. A highly-sensitive plasma von Willebrand factor ristocetin cofactor (VWF:RCo) activity assay by flow cytometry. (PubMed id 18031294)9 Chen D....Owen W.G. (J. Thromb. Haemost. 2008)
    724. von Willebrand factor standards for plasma and concentrate testing. (PubMed id 16862526)9 Hubbard A.R. (Semin. Thromb. Hemost. 2006)
    725. Von Willebrand factor can support platelet aggregation via interaction with activated GPIIb-IIIa and GPIb. (PubMed id 15745313)9 Naimushin Y.A. and Mazurov A.V. (Platelets 2004)
    726. The role of the D1 domain of the von Willebrand factor propeptide in multimerization of VWF. (PubMed id 12176890)9 Rosenberg J.B....Montgomery R.R. (Blood 2002)
    727. Function of von Willebrand factor in children with diarrhea-associated hemolytic-uremic syndrome (D+ HUS). (PubMed id 11446662)9 Sutor A.H....Zimmerhackl L.B. (Semin. Thromb. Hemost. 2001)
    728. Standardisation of factor VIII and von Willebrand factor in plasma: calibration of the 4th International Standard (97/586). (PubMed id 11341497)9 Hubbard A.R....Barrowcliffe T.W. (Thromb. Haemost. 2001)
    729. In vivo regulation of von willebrand factor synthesis: von Willebrand factor production in endothelial cells after lung transplantation between normal pigs and von Willebrand factor-deficient pigs. (PubMed id 10591687)9 Brouland J.P....Drouet L. (Arterioscler. Thromb. Vasc. Biol. 1999)
    730. von Willebrand factor (vWf) as a plasma marker of endothelial activation in diabetes: improved reliability with parallel determination of the vWf propeptide (vWf:AgII). (PubMed id 9869174)9 Vischer U.M....Ingerslev J. (Thromb. Haemost. 1998)
    731. Acquired von Willebrand disease caused by an autoantibody selectively inhibiting the binding of von Willebrand factor to collagen. (PubMed id 7949092)9 van Genderen P.J....van Vliet H.H. (Blood 1994)
    732. A new variant of von Willebrand's disease (type I Padua): doublet-organized plasma von Willebrand factor oligomers in the presence of all size multimers. (PubMed id 7890268)9 Casonato A....Girolami A. (Haematologia (Budap) 1994)
    733. Quantitative and qualitative assessment of plasma von Willebrand factor in classic Kaposi's sarcoma. (PubMed id 8432918)9 Hodak E....Inbal A. (J. Am. Acad. Dermatol. 1993)
    734. The association of factor VIII with von Willebrand factor. (PubMed id 1903173)9 Lollar P. (Mayo Clin. Proc. 1991)
    735. Limitations of the ristocetin cofactor assay in measurement of von Willebrand factor function. (PubMed id 19694940)9 Flood V.H....Montgomery R.R. (J. Thromb. Haemost. 2009)
    736. Identification of type 1 von Willebrand disease patients with reduced von Willebrand factor survival by assay of the VWF propeptide in the European study: molecular and clinical markers for the diagnosis and management of type 1 VWD (MCMDM-1VWD). (PubMed id 18344424)9 Haberichter S.L....Montgomery R.R. (Blood 2008)
    737. Laboratory diagnosis and monitoring of desmopressin treatment of von Willebrand's disease by flow cytometry. (PubMed id 18055988)9 Giannini S....Gresele P. (Haematologica 2007)
    738. Characterization of recessive severe type 1 and 3 von Willebrand Disease (VWD), asymptomatic heterozygous carriers versus bloodgroup O-related von Willebrand factor deficiency, and dominant type 1 VWD. (PubMed id 16959681)9 Michiels J.J....van Vliet H. (Clin. Appl. Thromb. Hemost. 2006)
    739. Comparative response of plasma VWF in dogs to up-regulation of VWF mRNA by interleukin-11 versus Weibel-Palade body release by desmopressin (DDAVP). (PubMed id 12649145)9 Olsen E.H....Nichols T.C. (Blood 2003)
    740. Linkage analysis of factor VIII and von Willebrand factor loci as quantitative trait loci. (PubMed id 12911592)9 De Visser M.C....Bertina R.M. (J. Thromb. Haemost. 2003)
    741. Molecular diagosis of von Willebrand disease. (PubMed id 12430915)9 Ruan C. (Int. J. Hematol. 2002)
    742. Type 2M von Willebrand disease variant characterized by abnormal von willebrand factor multimerization. (PubMed id 11150026)9 Casonato A....Girolami A. (J. Lab. Clin. Med. 2001)
    743. Control of von Willebrand factor multimer size by thrombospondin-1. (PubMed id 11413189)9 Xie L....Hogg P.J. (J. Exp. Med. 2001)
    744. [Von Willebrand factor in patients with subarachnoid hemorrhage]. (PubMed id 11935674)9 Beuth W....Sniegocki M. (Neurol. Neurochir. Pol. 2001)
    745. Detection of von Willebrand disorder and identification of qualitative von Willebrand factor defects. Direct comparison of commercial ELISA-based von Willebrand factor activity options. (PubMed id 11026108)9 Favaloro E.J. (Am. J. Clin. Pathol. 2000)
    746. Collagen-bound von Willebrand factor has reduced affinity for factor VIII. (PubMed id 10212199)9 Bendetowicz A.V....Gilbert G.E. (J. Biol. Chem. 1999)
    747. Abnormalities in circulating von Willebrand factor and survival in pulmonary hypertension. (PubMed id 9688017)9 Lopes A.A....Bydlowski S.P. (Am. J. Med. 1998)
    748. Molecular genetics of von Willebrand disease. (PubMed id 9599650)9 Mazurier C....Meyer D. (Ann. Genet. 1998)
    749. von Willebrand factor binds to native collagen VI primarily via its A1 domain. (PubMed id 9164855)9 Hoylaerts M.F....Vermylen J. (Biochem. J. 1997)
    750. Molecular basis of von Willebrand disease. (PubMed id 8800502)9 Mazurier C. and Meyer D. (Baillieres Clin. Haematol. 1996)
    751. The roles of von Willebrand factor and factor VIII in arterial thrombosis: studies in canine von Willebrand disease and hemophilia A. (PubMed id 8490173)9 Nichols T.C....Read M.S. (Blood 1993)
    752. A multispecies enzyme-linked immunosorbent assay for von Willebrand's factor. (PubMed id 1583394)9 Benson R.E....Dodds W.J. (J. Lab. Clin. Med. 1992)
    753. Studies on anti-von Willebrand factor (vWF) monoclonal antibody NMC-4, which inhibits both ristocetin- and botrocetin-induced vWF binding to platelet glycoprotein Ib. (PubMed id 1984791)9 Fujimura Y....Fukui H. (Blood 1991)
    754. Discrepant increase in factor VIII: C and von Willebrand factor after DDAVP infusion in a patient with variant von Willebrand's disease. (PubMed id 1768767)9 Casonato A....Girolami . (amp 1991)
    755. High von Willebrand factor concentration compensates a relative adhesion defect in uremic blood. (PubMed id 2156581)9 Zwaginga J.J....Sixma J.J. (Blood 1990)
    756. (PubMed id 19335767)9 
    757. Reduced ADAMTS13 in children with severe meningococcal sepsis is associated with severity and outcome. (PubMed id 20390223)9 Bongers T.N....Leebeek F.W. (Thromb. Haemost. 2010)
    758. Linear relationship between ADAMTS13 activity and platelet dynamics even before severe thrombocytopenia. (PubMed id 18988930)9 Song J....Choi J.R. (Ann. Clin. Lab. Sci. 2008)
    759. Loss of factor VIII and von Willebrand factor activities during cold storage of whole blood is reversed by rewarming. (PubMed id 16751138)9 Refaai M.A....Eby C.S. (Lab Hematol 2006)
    760. Serum von Willebrand factor, matrix metalloproteinase-9, and vascular endothelial growth factor levels predict the onset of cerebral vasospasm after aneurysmal subarachnoid hemorrhage. (PubMed id 12383357)9 McGirt M.J....Laskowitz D.T. (Neurosurgery 2002)
    761. A novel cause of mild/moderate hemophilia A: mutations scattered in the factor VIII C1 domain reduce factor VIII binding to von Willebrand factor. (PubMed id 10910910)9 Jacquemin M.... Saint-Remy J.-M.R. (Blood 2000)
    762. Abnormalities of von Willebrand factor are also part of the prothrombotic state of Cushing's syndrome. (PubMed id 10357009)9 Casonato A....Girolami A. (amp 1999)
    763. Inverse immunostaining pattern for synthesized versus endocytosed alpha-granule proteins in human bone marrow megakaryocytes. (PubMed id 9674731)9 de LarouziA"re V....Cramer E. (Br. J. Haematol. 1998)
    764. Relation of endothelium, thrombogenesis, and hemorheology in systemic hypertension to ethnicity and left ventricular hypertrophy. (PubMed id 9416937)9 Lip G.Y....Beevers D.G. (Am. J. Cardiol. 1997)
    765. Promotion of binding of von Willebrand factor to platelet glycoprotein Ib by dimers of ristocetin. (PubMed id 7887899)9 Hoylaerts M.F....Vermylen J. (Biochem. J. 1995)
    766. Lack of effect of 1-desamino-8-D-arginine vasopressin on direct adhesion of platelets to collagen. (PubMed id 7690994)9 Ghosh S. and Rao A.K. (Thromb. Res. 1993)
    767. A monoclonal antibody (NMC-VIII/10) to factor VIII light chain recognizing Glu1675-Glu1684 inhibits factor VIII binding to endogenous von Willebrand factor in human umbilical vein endothelial cells. (PubMed id 1390241)9 Shima M....Fukui H. (Br. J. Haematol. 1992)
    768. Aprotinin increases release of von Willebrand factor in cultured human umbilical vein endothelial cells. (PubMed id 1381524)9 Havel M.P....Wolner E. (Surgery 1992)
    769. DDAVP-induced release of von Willebrand factor from endothelial cells in vitro: the effect of plasma and blood cells. (PubMed id 2108732)9 Hashemi S....Ganz P.R. (Biochim. Biophys. Acta 1990)
    770. Plasma von Willebrand factor and thrombomodulin as markers of vascular disorders in patients undergoing regular hemodialysis therapy. (PubMed id 2162087)9 Tomura S....Marumo F. (Thromb. Res. 1990)
    771. Lower levels of ADAMTS13 are associated with cardiovascular disease in young patients. (PubMed id 19439298)9 Bongers T.N....Leebeek F.W. (Atherosclerosis 2009)
    772. Biomarkers of endothelial dysfunction are elevated and related to prognosis in chronic heart failure patients with diabetes but not in those without diabetes. (PubMed id 18343722)9 Kistorp C....Hildebrandt P. (Eur. J. Heart Fail. 2008)
    773. Evidence from limited proteolysis of a ristocetin-induced conformational change in human von Willebrand factor that promotes its binding to platelet glycoprotein Ib-IX-V. (PubMed id 17977030)9 Kang M....Kermode J.C. (amp 2008)
    774. Acute myocardial infarction as a systemic prothrombotic condition evidenced by increased von Willebrand factor protein over ADAMTS13 activity in coronary and systemic circulation. (PubMed id 18810578)9 Horii M....Saito Y. (Heart Vessels 2008)
    775. Macrophages contribute to the cellular uptake of von Willebrand factor and factor VIII in vivo. (PubMed id 18559674)9 van Schooten C.J....Lenting P.J. (Blood 2008)
    776. Simulation of platelet adhesion and aggregation regulated by fibrinogen and von Willebrand factor. (PubMed id 18217141)9 Mori D....Yamaguchi T. (Thromb. Haemost. 2008)
    777. VWF protects FVIII from endocytosis by dendritic cells and subsequent presentation to immune effectors. (PubMed id 16985172)9 Dasgupta S....Lacroix-Desmazes S. (Blood 2007)
    778. Cerebral venous thrombosis and plasma concentrations of factor VIII and von Willebrand factor: a case control study. (PubMed id 17189302)9 Bugnicourt J.M....Godefroy O. (J. Neurol. Neurosurg. Psychiatr. 2007)
    779. The cooperative activity between the carboxyl-terminal TSP1 repeats and the CUB domains of ADAMTS13 is crucial for recognition of von Willebrand factor under flow. (PubMed id 17540842)9 Zhang P....Zheng X.L. (Blood 2007)
    780. Haemorheological, platelet and endothelial indices in relation to global measures of cardiovascular risk in hypertensive patients: a substudy of the Anglo-Scandinavian Cardiac Outcomes Trial. (PubMed id 17222171)9 Spencer C.G....Lip G.Y. (J. Intern. Med. 2007)
    781. Increased cardiovascular risk markers in obesity are associated with body adiposity: role of leptin. (PubMed id 16732378)9 GA^mez-Ambrosi J....FrA1hbeck G. (Thromb. Haemost. 2006)
    782. Treatment of von Willebrand disease. (PubMed id 15662613)9 Rodeghiero F. and Castaman G. (Semin. Hematol. 2005)
    783. Ability of different glycoprotein IIb-IIIa ligands to support platelet aggregation induced by activating antibody CRC54. (PubMed id 16097942)9 Naimushin Y.A. and Mazurov A.V. (Biochemistry Mosc. 2005)
    784. Association of the antagonism of von Willebrand factor but not fibrinogen by platelet alphaIIbbeta3 antagonists with prolongation of bleeding time. (PubMed id 16150045)9 Aoki T....Mutoh S. (J. Thromb. Haemost. 2005)
    785. Biological and genetic factors influencing plasma factor VIII levels in a healthy family population: results from the Stanislas cohort. (PubMed id 15606554)9 Morange P.E....Juhan-Vague I. (Br. J. Haematol. 2005)
    786. Clearance of fibrinogen and von Willebrand factor in serial double-filtration plasmapheresis. (PubMed id 12874818)9 Lin S.M....Chiu H.C. (J Clin Apher 2003)
    787. Induction of megakaryocytes to synthesize and store a releasable pool of human factor VIII. (PubMed id 14675082)9 Wilcox D.A....Montgomery R.R. (J. Thromb. Haemost. 2003)
    788. Distinct and concerted functions of von Willebrand factor and fibrinogen in mural thrombus growth under high shear flow. (PubMed id 12393609)9 Matsui H....Yoshioka A. (Blood 2002)
    789. Insulin resistance is accompanied by increased von Willebrand factor levels in nondiabetic women: a study of offspring of type 2 diabetic subjects compared to offspring of nondiabetic subjects. (PubMed id 12190891)9 Foss C.H....Damsgaard E.M. (J. Intern. Med. 2002)
    790. Plasma vascular endothelial growth factor, soluble VEGF receptor FLT-1, and von Willebrand factor in glaucoma. (PubMed id 12386093)9 Lip P.L....Lip G.Y. (Br J Ophthalmol 2002)
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    792. Interleukin 11 significantly increases plasma von Willebrand factor and factor VIII in wild type and von Willebrand disease mouse models. (PubMed id 11154224)9 Denis C.V....Wagner D.D. (Blood 2001)
    793. [Changes in plasma von Willebrand factor and nitric oxide levels in patients with pregnancy induced hypertension]. (PubMed id 12536509)9 Jin L.P....Chen J.L. (Hunan Yi Ke Da Xue Xue Bao 2001)
    794. [Chronic peripheral arterial occlusive disease, platelet glycoproteins GPIIb-IIIa and GP Ib-IX, plasma von Willebrand factor and plasma fibrinogen concentrations in patients with type 2 diabetes mellitus]. (PubMed id 11236240)9 Gosk-Bierska I....Ciosek W. (Pol. Arch. Med. Wewn. 2000)
    795. Morphological differences between GPIb antibody-induced and shear stress-induced platelet aggregates. (PubMed id 11155036)9 Nomura S....Kambayashi J. (Haemostasis 2000)
    796. Partial inhibition of nitric oxide synthase primes the stimulated pathway of vWF-secretion in man. (PubMed id 10580169)9 Pernerstorfer T....Jilma B. (Atherosclerosis 2000)
    797. A new animal model of thrombophilia confirms that high plasma factor VIII levels are thrombogenic. (PubMed id 10064011)9 Kawasaki T....Hoylaerts M.F. (Thromb. Haemost. 1999)
    798. von Willebrand factor, tissue plasminogen activator, and dehydroepiandrosterone sulphate predict cardiovascular death in a 10 year follow up of survivors of acute myocardial infarction. (PubMed id 9875107)9 Jansson J.H....Johnson O. (Heart 1998)
    799. Heparins designed to specifically inhibit platelet interactions with von Willebrand factor. (PubMed id 8598091)9 Sobel M....Harris R.B. (Circulation 1996)
    800. Characterisation of type 2N von Willebrand disease using phenotypic and molecular techniques. (PubMed id 8822593)9 Nesbitt I.M....Peake I.R. (Thromb. Haemost. 1996)
    801. DDAVP infusion in haemophilia A carriers: different behaviour of plasma factor VIII and von Willebrand factor. (PubMed id 8874865)9 Casonato A....Girolami A. (amp 1996)
    802. SK&amp;F 96365 inhibits intracellular Ca2+ pumps and raises cytosolic Ca2+ concentration without production of nitric oxide and von Willebrand factor. (PubMed id 8985595)9 Iouzalen L....David-Dufilho M. (Cell Calcium 1996)
    803. Changes in factor VIII binding capacity of von Willebrand factor and factor VIII coagulant activity in two patients with type 2N von Willebrand disease after hemostatic treatment and during pregnancy. (PubMed id 8854570)9 Nishino M....Yoshioka A. (Int. J. Hematol. 1996)
    804. Preferential antagonism of the interactions of the integrin alpha IIb beta 3 with immobilized glycoprotein ligands by snake-venom RGD (Arg-Gly-Asp) proteins. Evidence supporting a functional role for the amino acid residues flanking the tripeptide RGD in determining the inhibitory properties of snake-venom RGD proteins. (PubMed id 7529494)9 Lu X....Rahman S. (Biochem. J. 1994)
    805. The relationship of arterial compliance with endothelial-derived proteins of the hemostatic system. (PubMed id 8445990)9 Smith D.H....Weber M.A. (Life Sci. 1993)
    806. Functional analysis of the Arg91Gln substitution in the factor VIII binding domain of von Willebrand factor demonstrates variable phenotypic expression. (PubMed id 8115998)9 Lavergne J.M....Meyer D. (Thromb. Haemost. 1993)
    807. Heparin binding assay of von Willebrand factor (vWF) in plasma milieu--evidence of the importance of the multimerization degree of vWF. (PubMed id 8322266)9 de Romeuf C. and Mazurier C. (Thromb. Haemost. 1993)
    808. Tissue-type plasminogen activator and von Willebrand factor plasma levels as markers of endothelial involvement in patients with Raynaud's phenomenon. (PubMed id 1459797)9 Marasini B....Agostoni A. (Int J Microcirc Clin Exp 1992)
    809. Influence of dry heat treatment and anticoagulant on coupling of fibrinogen and fibronectin to von Willebrand factor in normal plasma. (PubMed id 1333636)9 EllegAYrd K.H....Ingerslev J. (Scand. J. Clin. Lab. Invest. 1992)
    810. Shear stress-induced von Willebrand factor binding to platelet glycoprotein Ib initiates calcium influx associated with aggregation. (PubMed id 1611079)9 Chow T.W....Kroll M.H. (Blood 1992)
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    812. Molecular characterization of a unique von Willebrand disease variant. A novel mutation affecting von Willebrand factor/factor VIII interaction. (PubMed id 1906877)9 Cacheris P.M....Ginsburg D. (J. Biol. Chem. 1991)
    813. Variability in the fibrinogen and von Willebrand factor content of cryoprecipitate. Implications for reducing donor exposure. (PubMed id 2327369)9 Hoffman M. and Jenner P. (Am. J. Clin. Pathol. 1990)
    814. Evidence for a von Willebrand factor defect in factor VIII binding in three members of a family previously misdiagnosed mild haemophilia A and haemophilia A carriers: consequences for therapy and genetic counselling. (PubMed id 2124499)9 Mazurier C....Goudemand M. (Br. J. Haematol. 1990)
    815. Effects of carvedilol or metoprolol on PAI-1, tPA-mass concentration or Von Willebrand factor in chronic heart failure--a COMET substudy. (PubMed id 19762071)9 Boman K....Poole-Wilson P. (Thromb. Res. 2010)
    816. Evaluation of von Willebrand factor activity in factor VIII/von Willebrand factor concentrates with the automated von Willebrand factor: activity IL test. (PubMed id 20179578)9 Mori F....Farina C. (amp 2010)
    817. Establishment of reference intervals for von Willebrand factor antigen and eight coagulation factors in a Korean population following the Clinical and Laboratory Standards Institute guidelines. (PubMed id 20160641)9 Jang J.H....Kim S.H. (amp 2010)
    818. Potential role of enhanced cytokinemia and plasma inhibitor on the decreased activity of plasma ADAMTS13 in patients with alcoholic hepatitis: relationship to endotoxemia. (PubMed id 19094193)9 Ishikawa M....Fukui H. (Alcohol. Clin. Exp. Res. 2010)
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    820. The active conformation of von Willebrand factor in patients with thrombotic thrombocytopenic purpura in remission. (PubMed id 19548905)9 Groot E....Lenting P.J. (J. Thromb. Haemost. 2009)
    821. [Study on dynamic changes in coagulability and von Willebrand factor and its correlation with prognosis of cardiopulmonary resuscitation]. (PubMed id 20042140)9 Zhou J.X....Cheng R.N. (Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 2009)
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    823. Endothelial haemostatic markers in members of families with familial combined hyperlipidemia. (PubMed id 18417194)9 KarA!sek D....NovotnA1 D. (Thromb. Res. 2009)
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    825. Fibrinogen and von Willebrand factor mediated platelet adhesion to polystyrene under flow conditions. (PubMed id 18854129)9 Zhang M....Horbett T.A. (J Biomater Sci Polym Ed 2008)
    826. ADAMTS-13 activity in the presence of elevated von Willebrand factor levels as a novel mechanism of residual platelet reactivity in high risk coronary patients on antiplatelet treatment. (PubMed id 18603284)9 Marcucci R....Gori A.M. (Thromb. Res. 2008)
    827. Prospective evaluation of coagulopathy in multiple myeloma patients before, during and after various chemotherapeutic regimens. (PubMed id 18241919)9 van Marion A.M....Leebeek F.W. (Leuk. Res. 2008)
    828. Clinicopathologic correlation of retinal angiomatous proliferation. (PubMed id 19064845)9 Monson D.M....Wilson D.J. (Arch. Ophthalmol. 2008)
    829. Effect of adsorbed von Willebrand factor and fibrinogen on platelet interactions with synthetic materials under flow conditions. (PubMed id 17969019)9 Wu Y....Horbett T.A. (J Biomed Mater Res A 2008)
    830. Cerebral endothelial injury in elderly patients with severe head injury measured by serum thrombomodulin and von Willebrand factor. (PubMed id 17895610)9 Yokota H....Yamamoto Y. (Neurol. Med. Chir. (Tokyo) 2007)
    831. Increased von Willebrand factor over decreased ADAMTS13 activity may contribute to the development of liver disturbance and multiorgan failure in patients with alcoholic hepatitis. (PubMed id 17331163)9 Matsuyama T....Fukui H. (Alcohol. Clin. Exp. Res. 2007)
    832. The relationship between ABO groups and subgroups, factor VIII and von Willebrand factor. (PubMed id 17296574)9 Sousa N.C....Barjas-Castro M.L. (Haematologica 2007)
    833. Relationship between the binding sites for von Willebrand factor, phospholipid, and human factor VIII C2 inhibitor alloantibodies within the factor VIII C2 domain. (PubMed id 17483075)9 Nogami K....Yoshioka A. (Int. J. Hematol. 2007)
    834. Factor VIII inhibitors: role of von Willebrand factor on the uptake of factor VIII by dendritic cells. (PubMed id 18078399)9 Kaveri S.V....Lacroix-Desmazes S. (Haemophilia 2007)
    835. Effects of blood pressure on the prothrombotic risk in 1235 patients with non-valvular atrial fibrillation. (PubMed id 17005711)9 Varughese G.I....Lip G.Y. (Heart 2007)
    836. Increased circulating endothelial cells in acute heart failure: comparison with von Willebrand factor and soluble E-selectin. (PubMed id 16185922)9 Chong A.Y....Blann A.D. (Eur. J. Heart Fail. 2006)
    837. Effect of sedation on soluble P-selectin levels, coagulation and myocardial damage following a coronary intervention. (PubMed id 16700848)9 Yazici M....Sagkan O. (Int. J. Clin. Pract. 2006)
    838. Hemostasis and fibrinolysis in non-diabetic overweight and obese men and women. Is there still a role for leptin? (PubMed id 16914603)9 Mertens I....Van Gaal L.F. (Eur. J. Endocrinol. 2006)
    839. Plasma ADAMTS13 activity may predict early adverse events in living donor liver transplantation: observations in 3 cases. (PubMed id 16528712)9 Ko S....Nakajima Y. (Liver Transpl. 2006)
    840. [The association of von Willebrand factor and von Willebrand factor-cleaving protease in systemic lupus erythematosus]. (PubMed id 16624087)9 Lu G.Y....Ruan C.G. (Zhonghua Nei Ke Za Zhi 2006)
    841. Regulated release of VWF and FVIII and the biologic implications. (PubMed id 16470522)9 Haberichter S.L....Montgomery R.R. (amp 2006)
    842. The angiopoietin/Tie-2 system in proliferative sickle retinopathy: relation to vascular endothelial growth factor, its soluble receptor Flt-1 and von Willebrand factor, and to the effects of laser treatment. (PubMed id 15965157)9 Mohan J.S....Lip G.Y. (Br J Ophthalmol 2005)
    843. High pulse pressure and nondipping circadian blood pressure in patients with coronary artery disease: Relationship to thrombogenesis and endothelial damage/dysfunction. (PubMed id 15691624)9 Lee K.W....Lip G.Y. (Am. J. Hypertens. 2005)
    844. Angiogenic factors in atrial fibrillation: a possible role in thrombogenesis? (PubMed id 16179272)9 Freestone B....Lip G.Y. (Ann. Med. 2005)
    845. Reassessment of ABO blood group, sex, and age on laboratory parameters used to diagnose von Willebrand disorder: potential influence on the diagnosis vs the potential association with risk of thrombosis. (PubMed id 16416741)9 Favaloro E.J....Favaloro J.W. (Am. J. Clin. Pathol. 2005)
    846. Circulating endothelial cells in acute ischaemic stroke. (PubMed id 16270621)9 Nadar S.K....Blann A.D. (Thromb. Haemost. 2005)
    847. Type 2N von Willebrand disease. (PubMed id 16131435)9 Mazurier C. and Hilbert L. (Curr. Hematol. Rep. 2005)
    848. Identification of the amino acid residues of the platelet glycoprotein Ib (GPIb) essential for the von Willebrand factor binding by clustered charged-to-alanine scanning mutagenesis. (PubMed id 14757772)9 Shimizu A....Hirai M. (J. Biol. Chem. 2004)
    849. Factor VIII expression in liver disease. (PubMed id 14961153)9 Hollestelle M.J....van Mourik J.A. (Thromb. Haemost. 2004)
    850. Relationships between factor VIII:Ag and factor VIII in recombinant and plasma-derived factor VIII concentrates. (PubMed id 15357771)9 Lin Y....Ofosu F.A. (Haemophilia 2004)
    851. Plasma levels of von Willebrand factor regulate ADAMTS-13, its major cleaving protease. (PubMed id 15238142)9 Mannucci P.M....Canciani M.T. (Br. J. Haematol. 2004)
    852. Deletion of alanine 2201 in the FVIII C2 domain results in mild hemophilia A by impairing FVIII binding to VWF and phospholipids and destroys a major FVIII antigenic determinant involved in inhibitor development. (PubMed id 12969981)9 d'Oiron R....Jacquemin M. (Blood 2004)
    853. Thrombomodulin, von Willebrand factor and E-selectin as plasma markers of endothelial damage/dysfunction and activation in pregnancy induced hypertension. (PubMed id 15115667)9 Nadar S.K....Lip G.Y. (Thromb. Res. 2004)
    854. Viral load and disease progression as responsible for endothelial activation and/or injury in human immunodeficiency virus-1-infected patients. (PubMed id 12544723)9 de LarraA+aga G.F....Benetucci J.A. (amp 2003)
    855. Expression of human factor VIII under control of the platelet-specific alphaIIb promoter in megakaryocytic cell line as well as storage together with VWF. (PubMed id 12765843)9 Shi Q....Montgomery R.R. (Mol. Genet. Metab. 2003)
    856. [Effect of tongxinluo capsule on function of vascular endothelium in patients with unstable angina pectoris]. (PubMed id 14503056)9 Wang H.J....Sun J. (Zhongguo Zhong Xi Yi Jie He Za Zhi 2003)
    857. Shear stress and von Willebrand factor in health and disease. (PubMed id 14631548)9 Tsai H.M. (Semin. Thromb. Hemost. 2003)
    858. Surgery for gastric cancer increases plasma levels of vascular endothelial growth factor and von Willebrand factor. (PubMed id 12378339)9 Ikeda M....Satomi T. (Gastric Cancer 2002)
    859. Blood coagulation and fibrinolysis in patients with hyperthyroidism. (PubMed id 12030606)9 Erem C....Telatar M. (J. Endocrinol. Invest. 2002)
    860. Persistent increase in plasma thrombomodulin in patients with a history of lupus nephritis: endothelial cell activation markers. (PubMed id 11296951)9 Frijns R....Derksen R. (J. Rheumatol. 2001)
    861. Plasma homocysteine, methylene tetrahydrofolate reductase C677T and factor II G20210A polymorphisms, factor VIII, and VWF in central retinal vein occlusion. (PubMed id 11673296)9 Boyd S....Hykin P.G. (Br J Ophthalmol 2001)
    862. Endothelial perturbation in children and adolescents with type 1 diabetes: association with markers of the inflammatory reaction. (PubMed id 11522718)9 Romano M....DavA- G. (Diabetes Care 2001)
    863. Fibrinolytic actions of intra-arterial angiotensin II and bradykinin in vivo in man. (PubMed id 10974219)9 Labinjoh C....Webb D.J. (Cardiovasc. Res. 2000)
    864. Conformational changes in the D' domain of von Willebrand factor induced by CYS 25 and CYS 95 mutations lead to factor VIII binding defect and multimeric impairment. (PubMed id 10807780)9 Jorieux S....Mazurier C. (Blood 2000)
    865. Assembly of multimeric von Willebrand factor directs sorting of P-selectin. (PubMed id 10894814)9 Hop C....Pannekoek H. (Arterioscler. Thromb. Vasc. Biol. 2000)
    866. Enhanced shear-induced von Willebrand factor binding to platelets in acute myocardial infarction. (PubMed id 11113268)9 Li M....Handa S. (Thromb. Res. 2000)
    867. Soluble cell adhesion molecules in patients with acute coronary syndrome. (PubMed id 11775266)9 Xie Y....Gong L. (Chin. Med. J. 2000)
    868. Mosaic-like distribution of endothelial cell antigens in capillaries and juxta-alveolar microvessels in the normal human lung. (PubMed id 10792772)9 Kawanami O....Takemura T. (Pathol. Int. 2000)
    869. Effects of fixed low-dose warfarin, aspirin-warfarin combination therapy, and dose-adjusted warfarin on thrombogenesis in chronic atrial fibrillation. (PubMed id 10753983)9 Li-Saw-Hee F.L....Lip G.Y. ( a journal of cerebral circulation 2000)
    870. Heterogeneous distribution of thrombomodulin and von Willebrand factor in endothelial cells in the human pulmonary microvessels. (PubMed id 10754601)9 Kawanami O....Ferrans V.J. (J Nippon Med Sch 2000)
    871. Homocysteine concentration in primary and systemic sclerosis associated Raynaud's phenomenon. (PubMed id 11093443)9 Marasini B....Biondi M.L. (J. Rheumatol. 2000)
    872. A cross-sectional and diurnal study of thrombogenesis among patients with chronic atrial fibrillation. (PubMed id 10841245)9 Li-Saw-Hee F.L....Lip G.Y. (J. Am. Coll. Cardiol. 2000)
    873. Plasma VEGF and soluble VEGF receptor FLT-1 in proliferative retinopathy: relationship to endothelial dysfunction and laser treatment. (PubMed id 10892852)9 Lip P.L....Lip G.Y. (amp 2000)
    874. Identification and characterization of endothelial glycoprotein Ib using viper venom proteins modulating cell adhesion. (PubMed id 10194440)9 Tan L....Niewiarowski S. (Blood 1999)
    875. Effect of von Willebrand Factor and its proteolytic fragments on kinetics of interaction between the light and heavy chains of human factor VIII. (PubMed id 10605949)9 Saenko E.L....Sarafanov A.G. (Thromb. Res. 1999)
    876. Transcriptional expression of tissue factor pathway inhibitor, thrombomodulin and von Willebrand factor in normal human tissues. (PubMed id 10494762)9 Bajaj M.S....Bajaj S.P. (Thromb. Haemost. 1999)
    877. Socioeconomic status and determinants of hemostatic function in healthy women. (PubMed id 10073947)9 Wamala S.P....Orth-GomAcr K. (Arterioscler. Thromb. Vasc. Biol. 1999)
    878. The light chain of factor VIII comprises a binding site for low density lipoprotein receptor-related protein. (PubMed id 10446132)9 Lenting P.J....van Zonneveld A.J. (J. Biol. Chem. 1999)
    879. Antifactor VIII antibody inhibiting allogeneic but not autologous factor VIII in patients with mild hemophilia A. (PubMed id 10090936)9 Peerlinck K....Vermylen J. (Blood 1999)
    880. Endothelial haemostatic factors are associated with progression of urinary albumin excretion in clinically healthy subjects: a 4-year prospective study. (PubMed id 10369792)9 Clausen P....Jensen J.S. (Clin. Sci. 1999)
    881. Sex differences in coagulation and fibrinolysis in subjects with coronary artery disease. (PubMed id 9569183)9 Ossei-Gerning N....Grant P.J. (Thromb. Haemost. 1998)
    882. The evaluation of factor VIII binding activity of von Willebrand factor by means of an ELISA method: significance and practical implications. (PubMed id 9495210)9 Casonato A....Girolami A. (Am. J. Clin. Pathol. 1998)
    883. Diagnosis of von Willebrand disease type 2N: a simplified method for measurement of factor VIII binding to von Willebrand factor. (PubMed id 9692396)9 Miller C.H....Green D. (Am. J. Hematol. 1998)
    884. Clinical management of patients with von Willebrand's disease with a VHP vWF concentrate: the French experience. (PubMed id 10028319)9 Goudemand J....Sultan Y. (Haemophilia 1998)
    885. Evidence of a local mechanism for desmopressin-induced tissue-type plasminogen activator release in human forearm. (PubMed id 9427706)9 Wall U....Jern C. (Blood 1998)
    886. Requirement of prestimulated THP-1 monocytic cells for endothelial cell activation. Involvement of TNF alpha. (PubMed id 9105636)9 Roux M.E....Dosne A.M. (amp 1997)
    887. Effects of hormone-replacement therapy on hemostatic factors, lipid factors, and endothelial function in women undergoing surgical menopause: implications for prevention of atherosclerosis. (PubMed id 9351746)9 Lip G.Y....Beevers D.G. (Am. Heart J. 1997)
    888. Endothelial cell markers in bone marrow transplant recipients with and without acute graft-versus-host disease. (PubMed id 9156265)9 Salat C....Hiller E. (Bone Marrow Transplant. 1997)
    889. Sympathoadrenal activation and muscarinic receptor stimulation induce acute release of tissue-type plasminogen activator but not von Willebrand factor across the human forearm. (PubMed id 9268190)9 Jern C....Jern S. (Thromb. Haemost. 1997)
    890. Physiologic cleavage of von Willebrand factor by a plasma protease is dependent on its conformation and requires calcium ion. (PubMed id 8639782)9 Tsai H.M. (Blood 1996)
    891. Von Willebrand factor, thrombomodulin, thromboxane, beta-thromboglobulin and markers of fibrinolysis in primary Raynaud's phenomenon and systemic sclerosis. (PubMed id 8712862)9 Herrick A.L....Jayson M.I. (Ann. Rheum. Dis. 1996)
    892. Uremic patients have decreased shear-induced platelet aggregation mediated by decreased availability of glycoprotein IIb-IIIa receptors. (PubMed id 8604704)9 Sreedhara R....Hakim R.M. (Am. J. Kidney Dis. 1996)
    893. Factor VIII C2 domain missense mutations exhibit defective trafficking of biologically functional proteins. (PubMed id 8810344)9 Pipe S.W. and Kaufman R.J. (J. Biol. Chem. 1996)
    894. Purification and characterization of bitiscetin, a novel von Willebrand factor modulator protein from Bitis arietans snake venom. (PubMed id 8806626)9 Hamako J....Titani K. (Biochem. Biophys. Res. Commun. 1996)
    895. Factor VIII inhibitor antibodies with C2 domain specificity are less inhibitory to factor VIII complexed with von Willebrand factor. (PubMed id 8950785)9 Suzuki T....Fukutake K. (Thromb. Haemost. 1996)
    896. Increased plasma levels of immunoreactive endothelin and von Willebrand factor in NIDDM patients. (PubMed id 7698054)9 Morise T....Takeda R. (Diabetes Care 1995)
    897. The role of von Willebrand factor in haemostasis and blood loss during and after cardiopulmonary bypass surgery. (PubMed id 8562836)9 Perrin E.J....Hawson G.A. (amp 1995)
    898. [Subcutaneous administration of desmopressin to plasma donors: a controlled study]. (PubMed id 8523926)9 Palacios S....Vicente V. (Med Clin (Barc) 1995)
    899. Fibrinogen and markers of fibrinolysis and endothelial damage following resolution of critical limb ischaemia. (PubMed id 7552524)9 Woodburn K.R....Pollock J.G. (Eur J Vasc Endovasc Surg 1995)
    900. Hemostatic abnormalities in patients with pulmonary embolism compared with that in deep vein thrombosis. (PubMed id 8562833)9 Yamada N....Suzuki K. (amp 1995)
    901. Biological effect of desmopressin in eight patients with type 2N ('Normandy') von Willebrand disease. Collaborative Group. (PubMed id 7819109)9 Mazurier C....Goudemand M. (Br. J. Haematol. 1994)
    902. [Coagulation and fibrinolytic parameters in patients with various angiopathies--analysis in cerebral thrombosis, diabetic and vasculitic neuropathies]. (PubMed id 8403679)9 Kohriyama T....Nakamura S. (Rinsho Shinkeigaku 1993)
    903. Abnormalities of von Willebrand factor multimers in drug-associated thrombotic microangiopathies. (PubMed id 8438900)9 Charba D....Hester J.P. (Am. J. Hematol. 1993)
    904. Transmembrane calcium influx associated with von Willebrand factor binding to GP Ib in the initiation of shear-induced platelet aggregation. (PubMed id 8391728)9 Ikeda Y....Itagaki I. (Thromb. Haemost. 1993)
    905. Repeated infusions of DDAVP induce low response of FVIII and vWF but not of plasminogen activators. (PubMed id 8322282)9 Vicente V....Aznar J. (Thromb. Res. 1993)
    906. Further evidence for recessive inheritance of von Willebrand disease with abnormal binding of von Willebrand factor to factor VIII. (PubMed id 1566742)9 LA^pez-FernA!ndez M.F....Batlle J. (Am. J. Hematol. 1992)
    907. Aurin tricarboxylic acid inhibits platelet adhesion to collagen by binding to the 509-695 disulphide loop of von Willebrand factor and competing with glycoprotein Ib. (PubMed id 1287886)9 Girma J.P....Meyer D. (Thromb. Haemost. 1992)
    908. Monocytes enhance endothelial von Willebrand factor release and prostacyclin production with different kinetics and dependency on intercellular contact between these two cell types. (PubMed id 1581234)9 Hakkert B.C....van Mourik J.A. (Br. J. Haematol. 1992)
    909. Impaired release of tissue plasminogen activator (t-PA) following DDAVP infusion in von Willebrand's disease with low platelet von Willebrand factor content. (PubMed id 1606286)9 Casonato A....Girolami A. (amp 1992)
    910. Aprotinin does not inhibit the release of PGI2 or vWF from cultured human endothelial cells. (PubMed id 1377415)9 Royston B.D....Pearson J.D. (Thromb. Haemost. 1992)
    911. Fibrinolytic system during long-distance running in IDDM patients and in healthy subjects. (PubMed id 1505332)9 van Loon B.J....Meinders A.E. (Diabetes Care 1992)
    912. The mutation Arg (53)----Trp causes von Willebrand disease Normandy by abolishing binding to factor VIII. Studies with recombinant von Willebrand factor. (PubMed id 1732004)9 Jorieux S....Sadler J.E. (Blood 1992)
    913. Qualitative assessment of von Willebrand factor (vWF) in cirrhotics following repeated doses of desmopressin acetate. (PubMed id 1909903)9 Cardin F....Burroughs A.K. (amp 1991)
    914. Abnormal binding of factor VIII is linked with the substitution of glutamine for arginine 91 in von Willebrand factor in a variant form of von Willebrand disease. (PubMed id 1918030)9 Kroner P.A....Montgomery R.R. (J. Biol. Chem. 1991)
    915. Ristocetin and botrocetin involve two distinct domains of von Willebrand factor for binding to platelet membrane glycoprotein Ib. (PubMed id 1702906)9 Girma J.P....Meyer D. (Thromb. Haemost. 1990)
    916. Studies on the pathogenesis of coagulopathy in patients with arterial thromboembolism and malignancy. (PubMed id 2148228)9 Uchiyama T....Kobayashi N. (Thromb. Res. 1990)
    917. Secondhand smoke (SHS) exposure is associated with circulating markers of inflammation and endothelial function in adult men and women. (PubMed id 19700161)9 Jefferis B.J....Whincup P.H. (Atherosclerosis 2010)
    918. Von Willebrand factor, ADAMTS-13, and thrombotic thrombocytopenic purpura. (PubMed id 20391298)9 Zhou Z....Dong J.F. (Semin. Thromb. Hemost. 2010)
    919. 25-Hydroxyvitamin D and pre-clinical alterations in inflammatory and hemostatic markers: a cross sectional analysis in the 1958 British Birth Cohort. (PubMed id 20520739)9 HyppAPnen E....Power C. (PLoS ONE 2010)
    920. [Homocysteine and von Willebrand factor in chronic alcoholism]. (PubMed id 20524338)9 Koriakin A.M....GorbatovskiA- I.a.A. (Klin. Lab. Diagn. 2010)
    921. Coagulation factors as biological risk markers of endothelial dysfunction. Association with the thrombotic episodes of chronic hemodialysis patients. (PubMed id 20011089)9 Sioulis A....Grekas D. (Hippokratia 2009)
    922. Managing patients with von Willebrand disease type 1, 2 and 3 with desmopressin and von Willebrand factor-factor VIII concentrate in surgical settings. (PubMed id 19506363)9 Michiels J.J....Gadisseur A. (Acta Haematol. 2009)
    923. von Willebrand factor is a major determinant of ADAMTS-13 decrease during mouse sepsis induced by cecum ligation and puncture. (PubMed id 19187073)9 Lerolle N....Baruch D. (J. Thromb. Haemost. 2009)
    924. Effect of Ginkgo leaf extract on vascular endothelial function in patients with early stage diabetic nephropathy. (PubMed id 19271166)9 Li X.S....Ye S.H. (Chin J Integr Med 2009)
    925. [Clinical effect and mechanismn of xuefu zhuyu capsule in treating unstable angina pectoris]. (PubMed id 19338157)9 Zheng G.L. and Wang S.H. (Zhongguo Zhong Xi Yi Jie He Za Zhi 2009)
    926. von Willebrand factor-cleaving protease ADAMTS13 reduces ischemic brain injury in experimental stroke. (PubMed id 19687510)9 Zhao B.Q....Wagner D.D. (Blood 2009)
    927. Effects of losartan on fibrinolytic parameters and von Willebrand factor in Chinese subjects with hypertension: a comparative study versus atenolol. (PubMed id 19589241)9 Liu J....Huang J.H. (J. Int. Med. Res. 2009)
    928. Oxidative stress but not endothelial dysfunction exists in non-obese, young group of patients with polycystic ovary syndrome. (PubMed id 19308750)9 KuA9Asu N.K. and Var A. (Acta Obstet Gynecol Scand 2009)
    929. Proliferative diabetic retinopathy-The influence of diabetes control on the activation of the intraocular molecule system. (PubMed id 19237221)9 Adamiec-Mroczek J....Misiuk-HojA8o M. (Diabetes Res. Clin. Pract. 2009)
    930. [Development of a monoclonal antibody to factor VIII C2 domain and its functional study]. (PubMed id 19642361)9 Li Z.Y....Ruan C.G. (Zhonghua Xue Ye Xue Za Zhi 2009)
    931. In vitro plasma-induced endothelial oxidative stress and circulating markers of endothelial dysfunction in preeclampsia: an observational study. (PubMed id 19437231)9 Pottecher J....Tsatsaris V. (Hypertens Pregnancy 2009)
    932. Early initiation of low-dose atorvastatin treatment after an acute ST-elevated myocardial infarction, decreases inflammatory process and prevents endothelial injury and activation. (PubMed id 18187214)9 Stefanadi E....Stefanadis C. (Int. J. Cardiol. 2009)
    933. ADAMTS-13 attenuates thrombus formation on type I collagen surface and disrupted plaques under flow conditions. (PubMed id 18801485)9 Moriguchi-Goto S....Asada Y. (Atherosclerosis 2009)
    934. Levothyroxine (LT4) suppression treatment for benign thyroid nodules alters coagulation. (PubMed id 19138314)9 Demir T....Yesil S. (Clin. Endocrinol. (Oxf) 2009)
    935. Decreased ADAMTS13 levels in patients after living donor liver transplantation. (PubMed id 19423151)9 Kobayashi T....Isaji S. (Thromb. Res. 2009)
    936. Increased thrombin-activatable fibrinolysis inhibitor and decreased tissue factor pathway inhibitor in patients with hypothyroidism. (PubMed id 18958631)9 Erem C....Ersoz H.O. (Endocrine 2009)
    937. Influence of atrial fibrillation on plasma von willebrand factor, soluble E-selectin, and N-terminal pro B-type natriuretic peptide levels in systolic heart failure. (PubMed id 18339785)9 Freestone B....Lip G.Y. (Chest 2008)
    938. Reduced number and activity of circulating endothelial progenitor cells in patients with idiopathic pulmonary arterial hypertension. (PubMed id 18394873)9 Junhui Z....Junzhu C. (Respir Med 2008)
    939. Flow induces loop-to-beta-hairpin transition on the beta-switch of platelet glycoprotein Ib alpha. (PubMed id 18772372)9 Lou J. and Zhu C. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    940. Biologic response to subcutaneous and intranasal therapy with desmopressin in a large Amish kindred with Type 2M von Willebrand disease. (PubMed id 18312368)9 Sharthkumar A....Shapiro A. (Haemophilia 2008)
    941. Association between thrombotic microangiopathy and reduced ADAMTS13 activity in malignant hypertension. (PubMed id 18332284)9 van den Born B.J....van Montfrans G.A. (Hypertension 2008)
    942. Evidence-based diagnosis of type 1 von Willebrand disease: a Bayes theorem approach. (PubMed id 18187661)9 Tosetto A....Rodeghiero F. (Blood 2008)
    943. A phase II prospective open-label escalating dose trial of recombinant interleukin-11 in mild von Willebrand disease. (PubMed id 18680527)9 Ragni M.V....Nichols T.C. (Haemophilia 2008)
    944. Changes in plasma von Willebrand factor-cleaving protease (ADAMTS13) levels in patients with unstable angina. (PubMed id 18295305)9 Fuchigami S....Ogawa H. (Thromb. Res. 2008)
    945. [Effects of puerarin with aspirin on the markers of damaged vascular endothelial cells in patients with acute cerebral infarction]. (PubMed id 19260323)9 Hu H.T....Ding M.P. (Zhongguo Zhong Yao Za Zhi 2008)
    946. PFA-100 monitoring of von Willebrand factor (VWF) responses to desmopressin (DDAVP) and factor VIII/VWF concentrate substitution in von Willebrand disease type 1 and 2. (PubMed id 18766263)9 van Vliet H.H....Michiels J.J. (Thromb. Haemost. 2008)
    947. ADAMTS13 cleavage efficiency is altered by mutagenic and, to a lesser extent, polymorphic sequence changes in the A1 and A2 domains of von Willebrand factor. (PubMed id 18986390)9 Pruss C.M....Lillicrap D. (Br. J. Haematol. 2008)
    948. Interaction of the cysteine-rich domain of snake venom metalloproteinases with the A1 domain of von Willebrand factor promotes site-specific proteolysis of von Willebrand factor and inhibition of von Willebrand factor-mediated platelet aggregation. (PubMed id 17578514)9 Serrano S.M....Fox J.W. (FEBS J. 2007)
    949. An IAP retrotransposon in the mouse ADAMTS13 gene creates ADAMTS13 variant proteins that are less effective in cleaving von Willebrand factor multimers. (PubMed id 17426255)9 Zhou W....Tsai H.M. (Blood 2007)
    950. Coagulation, fibrinolytic system activation and endothelial dysfunction in patients with mitral stenosis and sinus rhythm. (PubMed id 17351162)9 Topaloglu S....Korkmaz S. (Angiology 2007)
    951. Differences in inflammatory and thrombotic markers between unstable angina and acute myocardial infarction. (PubMed id 16787670)9 Tousoulis D....Stefanadis C. (Int. J. Cardiol. 2007)
    952. Mapping von Willebrand factor A domain binding sites on a snake venom metalloproteinase cysteine-rich domain. (PubMed id 17118332)9 Pinto A.F....Fox J.W. (Arch. Biochem. Biophys. 2007)
    953. Serial changes in von Willebrand factor-cleaving protease (ADAMTS13) and prognosis after acute myocardial infarction. (PubMed id 17719316)9 Matsukawa M....Ogawa H. (Am. J. Cardiol. 2007)
    954. Time course of platelet activation and von Willebrand factor in patients with non-valvular atrial fibrillation after ischemic stroke. (PubMed id 17322628)9 Yip H.K....Liou C.W. (Circ. J. 2007)
    955. The effects of direct current cardioversion for persistent atrial fibrillation on indices of endothelial damage/dysfunction. (PubMed id 16318868)9 Freestone B....Lip G.Y. (Thromb. Res. 2006)
    956. Analysis on the molecular species and concentration of circulating ADAMTS13 in Blood. (PubMed id 16428330)9 Soejima K....Nakagaki T. (J. Biochem. 2006)
    957. Endothelial activation, dysfunction, and damage in congestive heart failure and the relation to brain natriuretic peptide and outcomes. (PubMed id 16490435)9 Chong A.Y....Lip G.Y. (Am. J. Cardiol. 2006)
    958. Impaired flow-mediated vasodilation, carotid artery intima-media thickening, and elevated endothelial plasma markers in obese children: the impact of cardiovascular risk factors. (PubMed id 16651309)9 Meyer A.A....Kienast W. (Pediatrics 2006)
    959. Endothelial dysfunction and systemic inflammation in persons with echolucent carotid plaques. (PubMed id 16807651)9 With NotA...Hansen J.B. (Thromb. Haemost. 2006)
    960. The role of ADAMT-13 in platelet adhesion in flow: methods for diagnosis of thrombotic thrombocytopenic purpura. (PubMed id 16855353)9 Shenkman B. (Pathophysiol. Haemost. Thromb. 2006)
    961. Validity of plasma fibrinogen, D-dimer, and the von Willebrand factor as markers of cardiovascular morbidity in patients on chronic hemodialysis. (PubMed id 16449948)9 Kirmizis D....Barboutis K. (Med. Sci. Monit. 2006)
    962. The 80th anniversary of von Willebrand's disease: history, management and research. (PubMed id 17083505)9 Federici A.B....Lee C.A. (Haemophilia 2006)
    963. Genetic influences on fibrinogen, tissue plasminogen activator-antigen and von Willebrand factor in males and females. (PubMed id 16525567)9 de Lange M....Snieder H. (Thromb. Haemost. 2006)
    964. The association between fibrinogen, von Willebrand Factor, antithrombin III, and D-dimer levels and survival outcome by 36 months from ovarian cancer. (PubMed id 16444428)9 Koh S.C....Choolani M. (Clin. Appl. Thromb. Hemost. 2006)
    965. Plasma haemostatic markers, endothelial function and ambulatory blood pressure changes with home versus hospital cardiac rehabilitation: the Birmingham Rehabilitation Uptake Maximisation Study. (PubMed id 16807272)9 Lee K.W....Lip G.Y. (Heart 2006)
    966. Interplay between ADAMTS13 and von Willebrand factor in inherited and acquired thrombotic microangiopathies. (PubMed id 15662617)9 Soejima K. and Nakagaki T. (Semin. Hematol. 2005)
    967. Inflammatory response and re-stenosis after percutaneous coronary intervention in heart transplant recipients and patients with native atherosclerosis. (PubMed id 16102437)9 Hognestad A....Andreassen A.K. (J. Heart Lung Transplant. 2005)
    968. Impaired tissue Doppler diastolic function in patients with coronary artery disease: relationship to endothelial damage/dysfunction and platelet activation. (PubMed id 16209979)9 Lee K.W....Lip G.Y. (Am. Heart J. 2005)
    969. Characterization of a myeloma patient with a life-threatening hemorrhagic diathesis: presence of a lambda dimer protein inhibiting shear-induced platelet aggregation by binding to the A1 domain of von Willebrand factor. (PubMed id 15886805)9 Shinagawa A....Nagasawa T. (Thromb. Haemost. 2005)
    970. Incremental shuttle walking is associated with activation of haemostatic and haemorheological markers in patients with coronary artery disease: the Birmingham rehabilitation uptake maximization study (BRUM). (PubMed id 15774609)9 Lee K.W....Lip G.Y. (Heart 2005)
    971. Cleavage of von Willebrand factor by ADAMTS-13 in vitro: effect of temperature and barium ions on the proteolysis kinetics. (PubMed id 16269936)9 Perutelli P....Molinari A.C. (amp 2005)
    972. [Von Willebrand disease: from diagnosis to treatment]. (PubMed id 16519045)9 Fressinaud E. and Meyer D. (Rev Prat 2005)
    973. Impact of surgery and chemotherapy on von Willebrand factor and vascular endothelial growth factor levels in colorectal cancer. (PubMed id 15960922)9 Gil-Bazo I....GarcA-a-Foncillas LA^pez J. (amp 2005)
    974. Lack of desmopressin (DDAVP) response in men with hemophilia A following liver transplantation. (PubMed id 16194203)9 Lamont P.A. and Ragni M.V. (J. Thromb. Haemost. 2005)
    975. Effects of exercise training and deconditioning on platelet aggregation induced by alternating shear stress in men. (PubMed id 15569820)9 Wang J.S....Chen Y.W. (Arterioscler. Thromb. Vasc. Biol. 2005)
    976. Plasma levels of tissue factor and soluble E-selectin in sickle cell disease: relationship to genotype and to inflammation. (PubMed id 15795541)9 Mohan J.S....Blann A.D. (amp 2005)
    977. [Study on changes of blood coagulation factors in rats with hemorrhagic shock]. (PubMed id 15748447)9 Zhang Y.J....Wang M.S. (Zhongguo Shi Yan Xue Ye Xue Za Zhi 2005)
    978. Insulin resistance and endothelial dysfunction in type 2 diabetes patients with or without microalbuminuria. (PubMed id 15223221)9 Yu Y....Tang H. (Diabetes Res. Clin. Pract. 2004)
    979. Endothelial nitric oxide synthase expression in neurogenic urinary bladders treated with intravesical resiniferatoxin. (PubMed id 14764132)9 Apostolidis A.N....Anand P. (BJU Int. 2004)
    980. Intense exercise increases shear-induced platelet aggregation in men through enhancement of von Willbrand factor binding, glycoprotein IIb/IIIa activation, and P-selectin expression on platelets. (PubMed id 14872251)9 Wang J.S. (Eur. J. Appl. Physiol. 2004)
    981. [Von Willebrand factor and thrombomodulin as markers of endothelial cell functions in children with chronic viral hepatitis]. (PubMed id 15557702)9 Kulwas A....Kotschy M. (Med Wieku Rozwoj 2004)
    982. Severity of venous insufficiency is related to the density of microvascular deposition of PAI-1, uPA and von Willebrand factor. (PubMed id 15061043)9 Kolbach D.N....Cleutjens J.P. (VASA 2004)
    983. Can von Willebrand factor, platelet-endothelial cell adhesion molecule-1 and thrombomodulin be used as alternative markers of endothelial cell injury in human glomerulonephritis? (PubMed id 15631346)9 Niemir Z.I....Czekalski S. (Rocz. Akad. Med. Bialymst. 2004)
    984. Haemostatic and inflammatory biomarkers in advanced chronic heart failure: role of oral anticoagulants and successful heart transplantation. (PubMed id 15198737)9 Cugno M....Gregorini L. (Br. J. Haematol. 2004)
    985. Endothelial dysfunction and damage in congestive heart failure: relation of flow-mediated dilation to circulating endothelial cells, plasma indexes of endothelial damage, and brain natriuretic peptide. (PubMed id 15364797)9 Chong A.Y....Lip G.Y. (Circulation 2004)
    986. Oxidised and native low-density lipoproteins induce the release of von Willebrand factor from human endothelial cells in vitro. (PubMed id 14560792)9 Blann A.D....McCollum C.N. (Br. J. Biomed. Sci. 2003)
    987. Acute release of plasminogen activator inhibitor-1 in ST-segment elevation myocardial infarction predicts mortality. (PubMed id 12860898)9 Collet J.P....Thomas D. (Circulation 2003)
    988. Von Willebrand disease type 1: a diagnosis in search of a disease. (PubMed id 12411289)9 Sadler J.E. (Blood 2003)
    989. Vitamin C affects thrombosis/ fibrinolysis system and reactive hyperemia in patients with type 2 diabetes and coronary artery disease. (PubMed id 14514574)9 Tousoulis D....Stefanadis C. (Diabetes Care 2003)
    990. Endothelial markers and HIV infection in the era of highly active antiretroviral treatment. (PubMed id 12893023)9 de LarraA+aga G.F....Benetucci J.A. (Thromb. Res. 2003)
    991. [Thrombomodulin, von Willebrand factor and tissue plasminogen activator in the blood plasma of obese women and men]. (PubMed id 15058251)9 RoA9A8 D....Michalski A. (Pol. Merkur. Lekarski 2003)
    992. Plasmatic nitric oxide, but not von Willebrand Factor, is an early marker of endothelial damage, in type 1 diabetes mellitus patients without microvascular complications. (PubMed id 12954155)9 Correa R.C. and Alfieri A.B. (J. Diabetes Complicat. 2003)
    993. Neither carvedilol nor bisoprolol in maximally tolerated doses has any specific advantage in lowering chronic heart failure oxidant stress: implications for beta-blocker selection. (PubMed id 12841846)9 Chin B.S....Lip G.Y. (Clin. Sci. 2003)
    994. Markers of endothelial function in pediatric stem cell transplantation for acute leukemia. (PubMed id 12426679)9 Luzzatto G....Zanesco L. (Med. Pediatr. Oncol. 2003)
    995. Prognostic value of plasma von Willebrand factor and soluble P-selectin as indices of endothelial damage and platelet activation in 994 patients with nonvalvular atrial fibrillation. (PubMed id 12796127)9 Conway D.S....Lip G.Y. (Circulation 2003)
    996. [Effect of tetramethylpyrazine on endothelin, von Willebrand factor and thromboxane A2 during cardiopulmonary bypass in patients of congenital heart disease with pulmonary hypertension]. (PubMed id 12764908)9 Huang R.J....Chen D.Z. (Zhongguo Zhong Xi Yi Jie He Za Zhi 2003)
    997. von Willebrand factor and its propeptide in children with diabetes. Relation between endothelial dysfunction and microalbuminuria. (PubMed id 12595584)9 Verrotti A....Chiarelli F. (Pediatr. Res. 2003)
    998. Angiogenesis, thrombogenesis, endothelial dysfunction and angiographic severity of coronary artery disease. (PubMed id 14617549)9 Chung N.A....Lip G.Y. (Heart 2003)
    999. Platelets' glycoproteins and their ligands in patients with intermittent claudication. (PubMed id 12865882)9 Gosk-Bierska I....Szuba A. (Int Angiol 2003)
    1000. Effects of dexamethasone on clinical course, C-reactive protein, S100B protein and von Willebrand factor antigen after paediatric cardiac surgery. (PubMed id 12765886)9 Lindberg L....Olsson A.K. (Br J Anaesth 2003)
    1001. Overexpression of von Willebrand factor is an independent risk factor for pathogenesis of intimal hyperplasia: preliminary studies. (PubMed id 12563218)9 Qin F....Dardik H. (J. Vasc. Surg. 2003)
    1002. Proline-rich tyrosine kinase 2 and focal adhesion kinase are involved in different phases of platelet activation by vWF. (PubMed id 11916084)9 Canobbio I....Torti M. (Thromb. Haemost. 2002)
    1003. Angiotensin-converting enzyme activity is involved in the mechanism of increased endogenous nitric oxide synthase inhibitor in patients with type 2 diabetes mellitus. (PubMed id 12224817)9 Ito A....Takeshita A. (Circ. J. 2002)
    1004. Uremic medium causes expression, redistribution and shedding of adhesion molecules in cultured endothelial cells. (PubMed id 12368160)9 Serradell M....Escolar G. (Haematologica 2002)
    1005. Comparative short-term prognostic value of hemostatic and inflammatory markers in patients with non-ST elevation acute coronary syndromes. (PubMed id 11899586)9 Passoni F....De Servi S. (Ital Heart J 2002)
    1006. Distinct glycoprotein Ib/V/IX and integrin alpha IIbbeta 3-dependent calcium signals cooperatively regulate platelet adhesion under flow. (PubMed id 11713259)9 Nesbitt W.S....Jackson S.P. (J. Biol. Chem. 2002)
    1007. Expression of the endothelial markers PECAM-1, vWf, and CD34 in vivo and in vitro. (PubMed id 12009786)9 MA1ller A.M....Kirkpatrick C.J. (Exp. Mol. Pathol. 2002)
    1008. Angiogenesis in pterygium: morphometric and immunohistochemical study. (PubMed id 12518239)9 Marcovich A.L....Bar-Dayan Y. (Curr. Eye Res. 2002)
    1009. Treatment of Raynaud's phenomenon with intravenous prostaglandin E1alpha-cyclodextrin improves endothelial cell injury in systemic sclerosis. (PubMed id 11327251)9 Gardinali M....Stabilini R. (J. Rheumatol. 2001)
    1010. Poly(ethylenimine)-mediated gene delivery affects endothelial cell function and viability. (PubMed id 11214758)9 Godbey W.T....Mikos A.G. (Biomaterials 2001)
    1011. Differential effects of radiocontrast agents on human umbilical vein endothelial cells: cytotoxicity and modulators of thrombogenicity. (PubMed id 11726305)9 Fauser C....Haller C. (Eur. J. Med. Res. 2001)
    1012. Abnormalities of hemorheological, endothelial, and platelet function in patients with chronic heart failure in sinus rhythm: effects of angiotensin-converting enzyme inhibitor and beta-blocker therapy. (PubMed id 11282905)9 Gibbs C.R....Lip G.Y. (Circulation 2001)
    1013. Increased soluble P-selectin in patients with haematological and breast cancer: a comparison with fibrinogen, plasminogen activator inhibitor and von Willebrand factor. (PubMed id 11229826)9 Blann A.D....Lip G.Y. (amp 2001)
    1014. Effect of acute exercise on the raised plasma fibrinogen, soluble P-selectin and von Willebrand factor levels in chronic atrial fibrillation. (PubMed id 11346250)9 Li-Saw-Hee F.L....Lip G.Y. (Clin Cardiol 2001)
    1015. Co-adsorbed fibrinogen and von Willebrand factor augment platelet procoagulant activity and spreading. (PubMed id 11334184)9 Grunkemeier J.M....Horbett T.A. (J Biomater Sci Polym Ed 2001)
    1016. Endothelial dysfunction, nitric oxide and platelet activation in hypertensive and diabetic type II patients. (PubMed id 11323020)9 OuviA+a S.M....Sassetti B. (Thromb. Res. 2001)
    1017. Effects of fixed low-dose warfarin on hemostatic factors in continuous ambulatory peritoneal dialysis patients. (PubMed id 11157376)9 Kim S.B....Yang W.S. (Am. J. Kidney Dis. 2001)
    1018. Haemostasis in ischaemic stroke and vascular dementia. (PubMed id 11734665)9 Stott D.J....Lowe G.D. (amp 2001)
    1019. Endothelial perturbation in cystic fibrosis. (PubMed id 11776300)9 Romano M....DavA- G. (Thromb. Haemost. 2001)
    1020. Sequential changes in von Willebrand factor and soluble thrombomodulin in acute ischemic stroke. (PubMed id 17903836)9 Nomura E....Nakamura S. (J Stroke Cerebrovasc Dis 2001)
    1021. Adherence properties of Staphylococcus aureus under static and flow conditions: roles of agr and sar loci, platelets, and plasma ligands. (PubMed id 11401988)9 Shenkman B....Varon D. (Infect. Immun. 2001)
    1022. Type 1 von Willebrand disease - a clinical retrospective study of the diagnosis, the influence of the ABO blood group and the role of the bleeding history. (PubMed id 10691852)9 Nitu-Whalley I.C....Pasi K.J. (Br. J. Haematol. 2000)
    1023. Von Willebrand's factor mediates the adherence of human tumoral cells to human endothelial cells and ticlopidine interferes with this effect. (PubMed id 11100896)9 Morganti M....Mittermayer C. (amp 2000)
    1024. Serum soluble vascular cell adhesion molecule-1: role as a surrogate marker of angiogenesis. (PubMed id 10944555)9 Byrne G.J....Bundred N.J. (J. Natl. Cancer Inst. 2000)
    1025. Mutation in the leucine-rich repeat of platelet glycoprotein Ib alpha results in defects in its interaction with immobilized von Willebrand factor under flow. (PubMed id 11776050)9 Dong J....LA^pez J.A. (Chin. Med. J. 2000)
    1026. Increased platelet activation and endothelial dysfunction in patients with atrial fibrillation immediately following percutaneous balloon mitral valvuloplasty. (PubMed id 10941544)9 Goldsmith I.R....Lip G.Y. (Clin Cardiol 2000)
    1027. von Willebrand factor binding to heparin in various types of von Willebrand disease. (PubMed id 11920189)9 Rastegar-Lari G....Baruch D. (Hematol. J. 2000)
    1028. A new approach to antiplatelet therapy: inhibitor of GPIb/V/IX-vWF interaction. (PubMed id 11182627)9 Ikeda Y....Goto S. (Haemostasis 2000)
    1029. von Willebrand factor, fibrinogen, and soluble P-selectin levels after mitral valve replacement versus mitral valve repair. (PubMed id 10802004)9 Goldsmith I.R....Lip G.Y. (Am. J. Cardiol. 2000)
    1030. Vascular endothelial growth factor expression and neovascularisation in non-small cell lung cancer. (PubMed id 10738124)9 Yano T....Horie T. (Eur. J. Cancer 2000)
    1031. Desmopressin: therapeutic limitations in children and adults with inherited coagulation disorders. (PubMed id 10929043)9 Nolan B....Smith O.P. (Br. J. Haematol. 2000)
    1032. The effect of adsorbed fibrinogen, fibronectin, von Willebrand factor and vitronectin on the procoagulant state of adherent platelets. (PubMed id 11026630)9 Grunkemeier J.M....Horbett T.A. (Biomaterials 2000)
    1033. Plasma fibrinogen, haemostatic factors and prediction of peripheral arterial disease in the Edinburgh Artery Study. (PubMed id 10691098)9 Smith F.B....Fowkes F.G. (amp 2000)
    1034. Local and systemic effects of intra-arterial desmopressin in healthy volunteers and patients with type 3 von Willebrand disease. Role of interleukin-6. (PubMed id 10959689)9 Newby D.E....Ludlam C.A. (Thromb. Haemost. 2000)
    1035. Analysis of the roles of 14-3-3 in the platelet glycoprotein Ib-IX-mediated activation of integrin alpha(IIb)beta(3) using a reconstituted mammalian cell expression model. (PubMed id 10579727)9 Gu M....Du X. (J. Cell Biol. 1999)
    1036. Correlation between von Willebrand factor levels and early graft function in clinical liver transplantation. (PubMed id 10081631)9 Basile J....Miller C.M. (Clin Transplant 1999)
    1037. Plasma levels of the three endothelial-specific proteins von Willebrand factor, tissue factor pathway inhibitor, and thrombomodulin do not predict the development of acute respiratory distress syndrome. (PubMed id 10654210)9 Bajaj M.S. and Tricomi S.M. (Intensive Care Med 1999)
    1038. Serotonin-induced secretion of von Willebrand factor from human umbilical vein endothelial cells via the cyclic AMP-signaling systems independent of increased cytoplasmic calcium concentration. (PubMed id 11230807)9 SchlA1ter T. and Bohnensack R. (Biochem. Pharmacol. 1999)
    1039. Real-time analysis of mural thrombus formation in various platelet aggregation disorders: distinct shear-dependent roles of platelet receptors and adhesive proteins under flow. (PubMed id 10419888)9 Tsuji S....Yoshioka A. (Blood 1999)
    1040. Platelet von Willebrand factor in Hermansky-Pudlak syndrome. (PubMed id 9766795)9 McKeown L.P....Rick M.E. (Am. J. Hematol. 1998)
    1041. Effects of human recombinant, plasma-derived and porcine von Willebrand factor in pigs with severe von Willebrand disease. (PubMed id 9690808)9 Roussi J....Drouet L. (amp 1998)
    1042. Impaired release of tissue plasminogen activator from the endothelium in Graves' disease - indicator of endothelial dysfunction and reduced fibrinolytic capacity. (PubMed id 9893018)9 Li Y....Sun X. (Eur. J. Clin. Invest. 1998)
    1043. In-vitro effect of oncostatin M on the release by endothelial cells of von Willebrand factor, tissue-type plasminogen activator and plasminogen activator inhibitor-1. (PubMed id 9863709)9 Pourtau J....Vasse M. (amp 1998)
    1044. Ser752 mutation to Pro or Ala in the beta3 integrin subunit differentially affects the kinetics of cell spreading to von Willebrand factor and fibrinogen. (PubMed id 9865467)9 Perrault C....Baruch D. (Cell Adhes. Commun. 1998)
    1045. Circulating von Willebrand factor antigen II in atherosclerosis: a comparison with von Willebrand factor and soluble thrombomodulin. (PubMed id 9663709)9 Blann A.D....McCollum C.N. (amp 1998)
    1046. Type 2M von Willebrand disease: F606I and I662F mutations in the glycoprotein Ib binding domain selectively impair ristocetin- but not botrocetin-mediated binding of von Willebrand factor to platelets. (PubMed id 9473222)9 Hillery C.A....Montgomery R.R. (Blood 1998)
    1047. A novel mutation in the D3 domain of von Willebrand factor markedly decreases its ability to bind factor VIII and affects its multimerization. (PubMed id 9845532)9 Jorieux S....Mazurier C. (Blood 1998)
    1048. Hemoperfusion with polymyxin B-immobilized fiber attenuates the increased plasma levels of thrombomodulin and von Willebrand factor from patients with septic shock. (PubMed id 9736787)9 Nakamura T....Koide H. (Blood Purif. 1998)
    1049. Effects of histamine and nitric oxide synthase inhibition on plasma levels of von Willebrand factor antigen. (PubMed id 9488498)9 Jilma B....Kapiotis S. (J. Lab. Clin. Med. 1998)
    1050. High plasminogen activator inhibitor and tissue plasminogen activator levels in plasma precede a first acute myocardial infarction in both men and women: evidence for the fibrinolytic system as an independent primary risk factor. (PubMed id 9826309)9 ThAPgersen A.M....Hallmans G. (Circulation 1998)
    1051. A study of desmopressin and blood loss during spinal fusion for neuromuscular scoliosis: a randomized, controlled, double-blinded study. (PubMed id 9286889)9 Theroux M.C....Kettrick R.G. (Anesthesiology 1997)
    1052. An endothelial storage granule for tissue-type plasminogen activator. (PubMed id 9314543)9 Emeis J.J....Lupu F. (J. Cell Biol. 1997)
    1053. Respective evaluation of the prevalence of haemostasis abnormalities in unexplained primary early recurrent miscarriages. The Nimes Obstetricians and Haematologists (NOHA) Study. (PubMed id 9241739)9 Gris J.C....MarA"s P. (Thromb. Haemost. 1997)
    1054. Percutaneous interventions alter the hemostatic profile of patients with unstable versus stable angina. (PubMed id 9350928)9 Yazdani S....Rabbani L.E. (J. Am. Coll. Cardiol. 1997)
    1055. von Willebrand factor and factor VIII: C in acute cerebrovascular disease. Relationship to stroke subtype and mortality. (PubMed id 9241740)9 Catto A.J....Grant P.J. (Thromb. Haemost. 1997)
    1056. Distribution of adhesion molecules on HeLa cells, platelets and endothelium in an in vitro model mimicking the early phase of metastasis. An immunogold electron microscopic study. (PubMed id 9269301)9 Klementsen B....rgensen L. (APMIS 1997)
    1057. Decreased half-life time of plasma von Willebrand factor collagen binding activity in essential thrombocythaemia: normalization after cytoreduction of the increased platelet count. (PubMed id 9432029)9 van Genderen P.J....Michiels J.J. (Br. J. Haematol. 1997)
    1058. Coexistence of anti-phospholipid antibodies and endothelial perturbation in systemic lupus erythematosus patients with ongoing prothrombotic state. (PubMed id 9118509)9 Ferro D....Violi F. (Circulation 1997)
    1059. Hemostasis in patients with severe von Willebrand disease improves after normal platelet transfusion and normalizes with further correction of the plasma defect. (PubMed id 9280321)9 Castillo R....Ordinas A. (Transfusion 1997)
    1060. Relative importance of the glycoprotein Ib-binding domain and the RGD sequence of von Willebrand factor for its interaction with endothelial cells. (PubMed id 9310484)9 Perrault C....Baruch D. (Blood 1997)
    1061. Lower androgenicity is associated with higher plasma levels of prothrombotic factors irrespective of age, obesity, body fat distribution, and related metabolic parameters in men. (PubMed id 9361687)9 De Pergola G....Giorgino R. (Metab. Clin. Exp. 1997)
    1062. Vascular endothelial lesion in patients undergoing bone marrow transplantation. (PubMed id 8932851)9 Richard S....Boisseau M. (Bone Marrow Transplant. 1996)
    1063. Proteolysis of von Willebrand factor is decreased in acute promyelocytic leukaemia by treatment with all-trans-retinoic acid. (PubMed id 8616045)9 Federici A.B....Mannucci P.M. (Br. J. Haematol. 1996)
    1064. Plasma von Willebrand Factor Antigen (vWF:AG) and thrombomodulin (TM) levels in Adult Thrombotic Thrombocytopenic Purpura/Hemolytic Uremic Syndromes (TTP/HUS) and bone marrow transplant-associated thrombotic microangiopathy (BMT-TM). (PubMed id 8948657)9 Zeigler Z.R....George J.N. (Am. J. Hematol. 1996)
    1065. Effect of deamino-8-D-arginine desmopressin in uremic bleeding. (PubMed id 8854651)9 Hong S.Y. and Yang D.H. (Korean J. Intern. Med. 1996)
    1066. Factor VII hyperactivity and endothelial cell damage are found in elderly hypertensives only when concomitant with microalbuminuria. (PubMed id 8630673)9 Kario K....Shimada K. (Arterioscler. Thromb. Vasc. Biol. 1996)
    1067. Raised serum sialic acid concentration precedes onset of microalbuminuria in IDDM. A 10-year follow-up study. (PubMed id 8732705)9 Yokoyama H....Deckert T. (Diabetes Care 1996)
    1068. The defective interaction between von Willebrand factor and factor VIII in a patient with type 1 von Willebrand disease is caused by substitution of Arg19 and His54 in mature von Willebrand factor. (PubMed id 8562925)9 Kroner P.A....Montgomery R.R. (Blood 1996)
    1069. Expression of tissue-type plasminogen activator, plasminogen activator inhibitor and von Willebrand factor in the supernatant of endothelial cell cultures in response to the seeding of adenocarcinoma cell line HRT-18. (PubMed id 8952858)9 Morganti M....Sagripanti A. (amp 1996)
    1070. von Willebrand factor, a possible indicator of endothelial cell damage, decreases during long-term compliance with a lipid-lowering diet. (PubMed id 7782727)9 Blann A.D....Watts G.F. (J. Intern. Med. 1995)
    1071. Hyperhomocysteinaemia and endothelial dysfunction in young patients with peripheral arterial occlusive disease. (PubMed id 7781664)9 Van den Berg M....Stehouwert C.D. (Eur. J. Clin. Invest. 1995)
    1072. Reactive oxygen intermediates induce regulated secretion of von Willebrand factor from cultured human vascular endothelial cells. (PubMed id 7756649)9 Vischer U.M....Theler J.M. (Blood 1995)
    1073. Increased markers of thrombogenesis in chronic atrial fibrillation: effects of warfarin treatment. (PubMed id 7626351)9 Lip G.Y....Dunn F.G. (Br Heart J 1995)
    1074. Different organization of von Willebrand factor oligomers in type-2A and -2B von Willebrand disease variants: effects of DDAVP infusion and protease inhibitors. (PubMed id 7578526)9 Casonato A....Girolami A. (Ann. Hematol. 1995)
    1075. Effect of nifedipine on changes in fibrinogen and von Willebrand factor in haemodialysis patients treated with recombinant human erythropoietin. (PubMed id 7605873)9 Taylor J.E....Stewart W.K. (amp 1995)
    1076. Endothelial haemostatic factors may be associated with mortality in patients on long-term anticoagulant treatment. (PubMed id 8584993)9 BrAonnstrAPm M....Nilsson T.K. (Thromb. Haemost. 1995)
    1077. Von Willebrand factor antigen in assessment of vasculitis in patients with connective tissue diseases. (PubMed id 8187441)9 Kloczko J....Radziwon P. (Clin. Rheumatol. 1994)
    1078. Absence of ligands bound to glycoprotein IIB-IIIA on the exposed surface of a thrombus may limit thrombus growth in flowing blood. (PubMed id 8083351)9 Heynen H.F....Sixma J.J. (J. Clin. Invest. 1994)
    1079. Multiple platelet surface receptors mediate platelet adhesion to surfaces coated with plasma proteins. (PubMed id 8041127)9 DiFazio L.T....Haimovich B. (J. Surg. Res. 1994)
    1080. Monoclonal antibodies to platelet glycoproteins Ib and IIb/IIIa inhibit adhesion of platelets to purified solid-phase von Willebrand factor. (PubMed id 8051492)9 Danton M.C....Olson J.D. (J. Lab. Clin. Med. 1994)
    1081. Secretory response of the vessel wall to DDAVP and venous occlusion in von Willebrand's disease. (PubMed id 7992599)9 Bykowska K....Lopaciuk S. (Acta Haematol Pol 1994)
    1082. Immunohistochemical staining of von Willebrand factor in endometrium of women during the first year of Norplant implants use. (PubMed id 7859456)9 Au C.L....Rogers P.A. (Contraception 1994)
    1083. Purification of factor VIII/von Willebrand factor from human plasma on immobilized lentil lectin. (PubMed id 8054845)