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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

VWF Gene

protein-coding   GIFtS: 70
GCID: GC12M006058

Von Willebrand Factor


(Previous symbol: F8VWF)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Von Willebrand Factor1 2
F8VWF1 2 3
VWD2
Coagulation Factor VIII VWF2
vWF3
F85

External Ids:    HGNC: 127261   Entrez Gene: 74502   Ensembl: ENSG000001107997   OMIM: 6131605   UniProtKB: P042753   

Export aliases for VWF gene to outside databases

Previous GC identifers: GC12M005930 GC12M005928 GC12M005917


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for VWF Gene:
The glycoprotein encoded by this gene functions as both an antihemophilic factor carrier and a platelet-vessel
wall mediator in the blood coagulation system. It is crucial to the hemostasis process. Mutations in this gene or
deficiencies in this protein result in von Willebrand's disease. An unprocessed pseudogene has been found on
chromosome 22. (provided by RefSeq, Jul 2008)

GeneCards Summary for VWF Gene: 
VWF (von Willebrand factor) is a protein-coding gene. Diseases associated with VWF include von willebrand's disease, and type 1 von willebrand disease, and among its related super-pathways are Formation of Fibrin Clot (Clotting Cascade) and Complement and Coagulation Cascades. GO annotations related to this gene include integrin binding and protein homodimerization activity. An important paralog of this gene is MUC5AC.

UniProtKB/Swiss-Prot: VWF_HUMAN, P04275
Function: Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular
injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor
complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury,
stabilizing its heterodimeric structure and protecting it from premature clearance from plasma

Gene Wiki entry for VWF (Von Willebrand factor) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.2  NT_009759.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the VWF gene promoter:
         AML1a   Chx10   MyoD   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidVWF promoter sequence
   Search SABiosciences Chromatin IP Primers for VWF

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat VWF


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13.3   Ensembl cytogenetic band:  12p13.31   HGNC cytogenetic band: 12p13.3

VWF Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
VWF gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M006058:  view genomic region     (about GC identifiers)

Start:
6,058,040 bp from pter      End:
6,233,936 bp from pter
Size:
175,897 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: VWF_HUMAN, P04275 (See protein sequence)
Recommended Name: von Willebrand factor precursor  
Size: 2813 amino acids; 309265 Da
Subunit: Multimeric. Interacts with F8
Subcellular location: Secreted. Secreted, extracellular space, extracellular matrix. Note=Localized to storage
granules
Sequence caution: Sequence=AAB59512.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of
unknown origin in the N-terminal part;
6/22 PDB 3D structures from and Proteopedia for VWF (see all 22):
1AO3 (3D)        1ATZ (3D)        1AUQ (3D)        1FE8 (3D)        1FNS (3D)        1IJB (3D)    
Secondary accessions: Q99806

Explore the universe of human proteins at neXtProt for VWF: NX_P04275

Explore proteomics data for VWF at MOPED 

Post-translational modifications:

  • UniProtKB: All cysteine residues are involved in intrachain or interchain disulfide bonds
  • UniProtKB: N- and O-glycosylated
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P04275

  • VWF Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    VWF Protein Expression
    REFSEQ proteins: NP_000543.2  
    ENSEMBL proteins: 
     ENSP00000261405   ENSP00000461331   ENSP00000459134   ENSP00000461318  
    Reactome Protein details: P04275
    Human Recombinant Protein Products for VWF: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for VWF (vWF-A2)
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    Novus Biologicals VWF Protein
    Novus Biologicals VWF Lysates
    Sino Biological Recombinant Protein for VWF
    Sino Biological Cell Lysate for VWF 
    ProSpec Recombinant Protein for VWF
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005578proteinaceous extracellular matrix IEA--
    GO:0005783endoplasmic reticulum IDA6754744
    GO:0009897external side of plasma membrane IEA--
    GO:0031012extracellular matrix IDA6754744

    VWF for ontologies           About GeneDecksing



    VWF Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/7 InterPro protein domains (see all 7):
     IPR014853 Unchr_dom_Cys-rich
     IPR012011 VWF
     IPR002919 TIL_dom
     IPR006207 Cys_knot_C
     IPR001007 VWF_C

    Graphical View of Domain Structure for InterPro Entry P04275

    ProtoNet protein and cluster: P04275

    5/6 Blocks protein domains (see all 6):
    IPB001007 von Willebrand factor
    IPB001839 Transforming growth factor beta (TGFb)
    IPB001846 Von Willebrand factor
    IPB002035 Von Willebrand factor type A domain signature
    IPB002919 Trypsin inhibitor-like


    UniProtKB/Swiss-Prot: VWF_HUMAN, P04275
    Domain: The von Willebrand antigen 2 is required for multimerization of vWF and for its targeting to storage
    granules
    Similarity: Contains 1 CTCK (C-terminal cystine knot-like) domain
    Similarity: Contains 4 TIL (trypsin inhibitory-like) domains
    Similarity: Contains 3 VWFA domains
    Similarity: Contains 3 VWFC domains
    Similarity: Contains 4 VWFD domains


    VWF for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: VWF_HUMAN, P04275
    Function: Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular
    injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor
    complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury,
    stabilizing its heterodimeric structure and protecting it from premature clearance from plasma

         Genatlas biochemistry entry for VWF:
    coagulation factor VIII (von Willebrand factor),expressed in endothelial megakaryocytes,stored in platelets
    alpha-granules and within the Weibel-Palade bodies of epitheliall cells and released into the plasma forming
    disulfide-linked multimeric structure,assembled from dimers

         Gene Ontology (GO): 5/10 molecular function terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001948glycoprotein binding IDA16409464
    GO:0002020protease binding IPI12775718
    GO:0005178integrin binding IPI9079671
    GO:0005515protein binding IPI11943773
    GO:0005518collagen binding IDA2056120
         
    VWF for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for VWF:
     Cell cycle / mitosis defect  Decreased NANOG protein expres  Decreased OCT4 protein express  Decreased POU5F1-GFP protein e 

         8 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Vwf):
     cardiovascular system  cellular  digestive/alimentary  hematopoietic system  homeostasis/metabolism 
     immune system  mortality/aging  nervous system 

    VWF for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Vwftm1Wgr for VWF

       inGenious Targeting Laboratory - Custom generated mouse model solutions for VWF 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for VWF

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for VWF 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for VWF 

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    Inhib. RNA
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    Gene Editing
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    Clone
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for VWF About   (see all 14)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Formation of Fibrin Clot (Clotting Cascade)
    Formation of Fibrin Clot (Clotting Cascade)0.59
    Blood Coagulation Signaling Pathways0.51
    Intrinsic Pathway0.59
    Blood Clotting Cascade0.42
    2Complement and coagulation cascades
    Complement and Coagulation Cascades0.71
    Complement and coagulation cascades0.71
    3Focal Adhesion
    Focal Adhesion0.64
    Focal adhesion0.64
    4Non-integrin membrane-ECM interactions
    ECM-receptor interaction0.42
    Integrin cell surface interactions0.32
    5Platelet degranulation
    Platelet degranulation 0.94
    Response to elevated platelet cytosolic Ca2+0.94

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for VWF
        Selected targets of C/EBPbeta

    1 R&D Systems Pathway for VWF
        Blood Coagulation Signaling Pathways


    3 BioSystems Pathways for VWF
        Focal Adhesion
    Blood Clotting Cascade
    Complement and Coagulation Cascades


    5/14        Reactome Pathways for VWF (see all 14)
        Hemostasis
    Platelet Adhesion to exposed collagen
    Integrin cell surface interactions
    GP1b-IX-V activation signalling
    Intrinsic Pathway

    1 PharmGKB Pathway for VWF
        Platelet Aggregation Inhibitor Pathway, Pharmacodynamics

    4         Kegg Pathways  (Kegg details for VWF):
        PI3K-Akt signaling pathway
    Focal adhesion
    ECM-receptor interaction
    Complement and coagulation cascades


    VWF for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for VWF

    STRING Interaction Network Preview (showing 5 interactants - click image to see 23)

    5/37 Interacting proteins for VWF (P042751, 2, 3 ENSP000002614054) via UniProtKB, MINT, STRING, and/or I2D (see all 37)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ZNF512BQ96KM62, 3MINT-60830 I2D: score=2 
    GP1BAP073591, 2, 3, ENSP000003293804EBI-981819,EBI-297082 MINT-17868 MINT-24838 I2D: score=3 STRING: ENSP00000329380
    ADAMTS13Q76LX81, 3, ENSP000003609974EBI-981819,EBI-981764 I2D: score=3 STRING: ENSP00000360997
    CALRP277973, ENSP000003208664I2D: score=3 STRING: ENSP00000320866
    COL1A1P024523, ENSP000002259644I2D: score=3 STRING: ENSP00000225964
    About this table

    Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001889liver development IEA--
    GO:0001890placenta development IEA--
    GO:0002576platelet degranulation TAS--
    GO:0007155cell adhesion IDA10764791
    GO:0007596blood coagulation TAS--

    VWF for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    VWF for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for VWF

    1 DrugBank Compound for VWF    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Antihemophilic FactorAHF (see all 3)--targetbinder2942172 2128855 14750934 11858481 10938981

    10/135 Novoseek inferred chemical compound relationships for VWF gene (see all 135)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ristocetin 97.1 956 7887899 (6), 19694940 (5), 17977030 (5), 14757772 (4) (see all 99)
    desmopressin 91.1 630 11992235 (10), 7690994 (6), 17164493 (6), 2108732 (6) (see all 99)
    fibrinogen 87.2 964 17650077 (9), 17622488 (7), 15745313 (7), 9416937 (6) (see all 99)
    crotalin 72.1 3 9473223 (2)
    calin 66 5 9490916 (1), 9164855 (1), 7833474 (1), 10494781 (1)
    aurintricarboxylic acid 65.6 39 1287886 (4), 18957047 (2), 7749846 (1), 9459348 (1) (see all 16)
    adp 64.9 103 2154674 (3), 2401846 (3), 8051492 (3), 2346725 (2) (see all 56)
    kogenate 63.9 9 7639276 (2), 18078401 (2), 7483501 (1), 11122270 (1) (see all 6)
    koate-hp 63.7 2 11563592 (1), 8191394 (1)
    rfviii 61.2 15 10456452 (2), 8199023 (1), 8652394 (1), 18983499 (1) (see all 7)

    Search CenterWatch for drugs/clinical trials and news about VWF

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for VWF gene: 
    NM_000552.3  

    Unigene Cluster for VWF:

    Von Willebrand factor
    Hs.440848  [show with all ESTs]
    Unigene Representative Sequence: NM_000552
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000261405(uc001qnn.1 uc010set.1) ENST00000538635 ENST00000539641
    ENST00000321023 ENST00000538563 ENST00000545906 ENST00000540192 ENST00000572068(uc001qno.1)

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Additional mRNA sequence: 

    AF086470.1 AK128487.1 AK292122.1 AK297600.1 BC022258.1 BC069030.1 K03028.1 M10321.1 
    M17588.1 U81237.1 X02672.1 X04146.1 X04385.1 

    21 DOTS entries:

    DT.91762387  DT.95170468  DT.121129090  DT.121129141  DT.100788530  DT.121129143  DT.100788527  DT.121129166 
    DT.97790477  DT.97846422  DT.121129157  DT.40121611  DT.95170466  DT.99966582  DT.429976  DT.91762385 
    DT.95292632  DT.75146000  DT.91762382  DT.95170467  DT.121129186 

    24/349 AceView cDNA sequences (see all 349):

    AW516991 X02672 BQ024352 BU077753 CA434711 BM931624 AA683280 CB266865 
    CD743187 AI131038 BM699079 T27768 AA323834 BQ722193 BQ709973 AL549326 
    BQ003750 AU140697 BQ882131 X04385 AU158381 AA304286 BQ898017 AU141516 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for VWF (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^
    SP1:                    -     -                             -                                                                                                   
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35 ^ 36 ^ 37 ^ 38a · 38b ^ 39a · 39b ^ 40 ^ 41 ^ 42 ^ 43 ^ 44 ^ 45 ^ 46 ^ 47a ·
    SP1:                                                                                                        -                                               -   
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 47b ^ 48 ^ 49a · 49b ^ 50a · 50b ^ 51 ^ 52 ^ 53
    SP1:              -                 -                     
    SP2:                                                      
    SP3:              -                                       
    SP4:                                                      
    SP5:                                                      


    ECgene alternative splicing isoforms for VWF

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    VWF expression in normal human tissues (normalized intensities)      VWF embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTCTGCTCTT
    VWF Expression
    About this image


    VWF expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/29 selected tissues (see all 29) fully expand
     
     Endothelium (Cardiovascular System)    fully expand to see all 39 entries
             Pericytes Microvessels
             PureStem endothelial progenitor 30-SM2-1
             Endothelial-like cells ( Generation of hematopoietic and endothelial progenitor cells...
             Human Pulmonary Microvascular Endothelial Cells (HPMEC)   
     
     Heart (Cardiovascular System)    fully expand to see all 7 entries
             Heart Tube
             Cardiac progenitor cells
             Human Cardiac Myocytes-adult (HCM-a)   
             mouse/organ system/cardiovascular system   
     
     Blood (Hematopoietic System)    fully expand to see all 7 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
             PureStem endothelial Progenitor 30-SM2-3
             bone marrow   
     
     Umbilical Cord (Extraembryonic Tissues)    fully expand to see all 6 entries
             Wharton's jelly-derived stem cells
             Human Umbilical Vein Endothelial Cells (HUVEC) (BioTime)   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 2 entries
             colon ; endothelial cells   
             Appendix   

    See VWF Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for VWF

    SOURCE GeneReport for Unigene cluster: Hs.440848

    UniProtKB/Swiss-Prot: VWF_HUMAN, P04275
    Tissue specificity: Plasma

        SABiosciences Expression via Pathway-Focused PCR Arrays including VWF: 
              Cell Surface Markers in human mouse rat
              Endothelial Cell Biology in human mouse rat
              Atherosclerosis in human mouse rat
              Mesenchymal Stem Cell in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for VWF
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat VWF
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat VWF
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat VWF
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VWF

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for VWF gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Vwf1 , 5 Von Willebrand factor homolog1, 5 83.68(n)1
    83.4(a)1
      6 (59.32 cM)5
    223711  NM_011708.41  NP_035838.31 
     1255467745 
    chicken
    (Gallus gallus)
    Aves VWF1 von Willebrand factor 61.76(n)
    56.69(a)
      419031  XM_417223.3  XP_417223.3 
    lizard
    (Anolis carolinensis)
    Reptilia VWF6
    Uncharacterized protein
    54(a)
    1 ↔ 1
    5(81821509-82024856)
    zebrafish
    (Danio rerio)
    Actinopterygii vwf1 von Willebrand factor 56.16(n)
    47.86(a)
      570643  XM_002665310.2  XP_002665356.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta Hml3 defense response sugar binding 30(a)   70C4   --


    ENSEMBL Gene Tree for VWF (if available)
    TreeFam Gene Tree for VWF (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for VWF gene
    MUC5AC2  ZAN2  TECTA2  OTOG2  OTOGL2  MUC5B2  MUC62  MUC192  
    FCGBP2  BMPER2  
    3 SIMAP similar genes for VWF using alignment to 5 protein entries:     VWF_HUMAN (see all proteins):
    COL21A1    FCGBP    MG1

    VWF for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for VWF
    PGOHUM00000246202


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/5204 SNPs in VWF are shown (see all 5204)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0058084
    Von Willebrand disease 2 (VWD2)4--see VAR_0058082 F C mis40--------
    VAR_0057924
    Von Willebrand disease 2 (VWD2)4--see VAR_0057922 H D mis40--------
    VAR_0058114
    Von Willebrand disease 2 (VWD2)4--see VAR_0058112 R G mis40--------
    VAR_0058144
    Von Willebrand disease 2 (VWD2)4--see VAR_0058142 V D mis40--------
    VAR_0057834
    Von Willebrand disease 2 (VWD2)4--see VAR_0057832 N S mis40--------
    VAR_0057944
    Von Willebrand disease 2 (VWD2)4--see VAR_0057942 R W mis40--------
    VAR_0058154
    Von Willebrand disease 2 (VWD2)4--see VAR_0058152 G R mis40--------
    VAR_0058094
    Von Willebrand disease 2 (VWD2)4--see VAR_0058092 L P mis40--------
    VAR_0091414
    Von Willebrand disease 2 (VWD2)4--see VAR_0091412 C Y mis40--------
    VAR_0057994
    Von Willebrand disease 2 (VWD2)4--see VAR_0057992 V L mis40--------

    HapMap Linkage Disequilibrium report for VWF (6058040 - 6233936 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for VWF:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2549788CNV Deletion19546169
    nsv509451CNV Insertion20534489
    esv269412CNV Insertion20981092
    dgv1350n71CNV Loss21882294
    nsv832320CNV Loss17160897
    nsv898631CNV Loss21882294
    nsv468988CNV Gain19166990
    nsv470262CNV Gain18288195
    esv26513CNV Gain19812545
    nsv898628CNV Gain21882294


    Human Gene Mutation Database (HGMD): VWF

    Locus Specific Mutation Databases (LSDB): VWF
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing VWF
    DNA2.0 Custom Variant and Variant Library Synthesis for VWF

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 613160   
    OMIM disorders: 613554  193400  277480  
    UniProtKB/Swiss-Prot: VWF_HUMAN, P04275
  • von Willebrand disease 1 (VWD1) [MIM:193400]: A common hemorrhagic disorder due to defects in von
    Willebrand factor protein and resulting in impaired platelet aggregation. Von Willebrand disease type 1 is
    characterized by partial quantitative deficiency of circulating von Willebrand factor, that is otherwise
    structurally and functionally normal. Clinical manifestations are mucocutaneous bleeding, such as epistaxis and
    menorrhagia, and prolonged bleeding after surgery or trauma. Note=The disease is caused by mutations affecting
    the gene represented in this entry
  • von Willebrand disease 2 (VWD2) [MIM:613554]: A hemorrhagic disorder due to defects in von Willebrand
    factor protein and resulting in altered platelet aggregation. Von Willebrand disease type 2 is characterized by
    qualitative deficiency and functional anomalies of von Willebrand factor. It is divided in different subtypes
    including 2A, 2B, 2M and 2N (Normandy variant). The mutant VWF protein in types 2A, 2B and 2M are defective in
    their platelet-dependent function, whereas the mutant protein in type 2N is defective in its ability to bind
    factor VIII. Clinical manifestations are mucocutaneous bleeding, such as epistaxis and menorrhagia, and prolonged
    bleeding after surgery or trauma. Note=The disease is caused by mutations affecting the gene represented in this
    entry
  • von Willebrand disease 3 (VWD3) [MIM:277480]: A severe hemorrhagic disorder due to a total or near total
    absence of von Willebrand factor in the plasma and cellular compartments, also leading to a profound deficiency
    of plasmatic factor VIII. Bleeding usually starts in infancy and can include epistaxis, recurrent mucocutaneous
    bleeding, excessive bleeding after minor trauma, and hemarthroses. Note=The disease is caused by mutations
    affecting the gene represented in this entry

  • 20/241 diseases for VWF (see all 241):    About MalaCards
    von willebrand's disease    type 1 von willebrand disease    type 2b von willebrand disease    acquired von willebrand syndrome
    type 2a von willebrand disease    type 3 von willebrand disease    type 2m von willebrand disease    qualitative platelet defect
    von willibrand disease, type 3    von willebrand disease, type 2a, 2b, 2m, and 2n    thrombotic thrombocytopenic purpura    type 2n von willebrand disease
    eisenmenger syndrome    autoimmune polyglandular syndrome type 3    angiodysplasia    intermittent claudication
    hemarthrosis    bernard-soulier syndrome    coronary thrombosis    african tick-bite fever

    14 diseases from the University of Copenhagen DISEASES database for VWF:
    Von Willebrand's disease     Vascular disease     Thrombophilia     Bernard-Soulier syndrome
    Thrombocytopenia     Heart disease     Glanzmann's thrombasthenia     Diabetes mellitus
    Brain disease     Anemia     Cancer     Connective tissue disease
    Kidney failure     Hypersensitivity reaction type II disease

    VWF for disorders           About GeneDecksing

    10/96 Novoseek inferred disease relationships for VWF gene (see all 96)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    von willebrand disease 97.8 680 8456322 (3), 8236134 (3), 9684782 (3), 1409710 (3) (see all 99)
    purpura thrombotic thrombocytopenic 87.5 100 8438900 (4), 19190805 (2), 9535389 (1), 10227776 (1) (see all 77)
    prolonged bleeding time 82.7 61 7750191 (2), 9881332 (1), 10583513 (1), 11601234 (1) (see all 38)
    von willebrand disease, platelet-type 82.2 11 19951970 (1), 1911886 (1), 7660135 (1), 12637314 (1) (see all 8)
    coagulopathy 81 122 8500791 (2), 18333911 (2), 9873810 (2), 8328650 (1) (see all 99)
    hemophilia a 78.4 41 8500791 (2), 8490173 (2), 8634427 (2), 19506355 (2) (see all 25)
    bleeding tendency 78 41 1284714 (2), 18055987 (2), 19506363 (1), 10595636 (1) (see all 27)
    bernard-soulier syndrome 76.3 12 8000916 (1), 8770359 (1), 20462086 (1), 7900092 (1) (see all 10)
    thrombosis 74.2 185 7823669 (4), 8490173 (4), 11380453 (2), 15870546 (2) (see all 99)
    bleeding 72.3 511 20008188 (5), 8562836 (4), 15166918 (4), 9766795 (3) (see all 99)

    Genatlas disease: VWF
    Willebrand disease,types I,II A and II B and recessive form

    GeneTests: VWF
    GeneReviews: VWF
    Genetic Association Database (GAD): VWF
    Human Genome Epidemiology (HuGE) Navigator: VWF (99 documents)

    Export disorders for VWF gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for VWF gene, integrated from 9 sources (see all 2702) (see top 10):
    (articles sorted by number of sources associating them with VWF)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel von Willebrand disease-causing mutation (Arg273Trp) in the von Willebrand factor propeptide that results in defective multimerization and secretion. (PubMed id 10887119)1, 2, 9 Allen S.... Daly M.E. (2000)
    2. von Willebrand factor storage and multimerization: 2 independent intracellular processes. (PubMed id 10961880)1, 2, 9 Haberichter S.L.... Montgomery R.R. (2000)
    3. The ABO blood group genotype and factor VIII levels as independent risk factors for venous thromboembolism. (PubMed id 15735796)1, 4, 9 Tirado I....Fontcuberta J. (2005)
    4. Measurement of von Willebrand factor-FVIII binding activity in patients with suspected von Willebrand disease type 2N: application of an ELISA-based assay in a reference laboratory. (PubMed id 19298374)1, 4, 9 Zhukov O....Sahud M. (2009)
    5. The Sma I polymorphism in the von Willebrand factor gene associated with acute ischemic stroke. (PubMed id 11755948)1, 4, 9 Dai K....Ruan C. (2001)
    6. von Willebrand disease type B: a missense mutation selectively abolishes ristocetin-induced von Willebrand factor binding to platelet glycoprotein Ib. (PubMed id 1409710)1, 2, 9 Rabinowitz I.... Sadler J.E. (1992)
    7. Distribution of von Willebrand factor levels in young women with and without bleeding symptoms: influence of ABO blood group and promoter haplotypes. (PubMed id 18521502)1, 4, 9 Lethagen S....Friberg B. (2008)
    8. The A/T1381 polymorphism in the A1-domain of von Willebrand factor influences the affinity of von Willebrand factor for platelet glycoprotein Ibalpha. (PubMed id 17598011)1, 4, 9 Szanto T....Vanhoorelbeke K. (2007)
    9. Genetic variability of von Willebrand factor and risk of coronary heart disease: the Rotterdam Study. (PubMed id 14717782)1, 4, 9 van der Meer I.M....Gomez Garcia E.B. (2004)
    10. Defective dimerization of von Willebrand factor subunits due to a Cys-> Arg mutation in type IID von Willebrand disease. (PubMed id 8622978)1, 2, 9 Schneppenheim R.... Ruggeri Z.M. (1996)
    11. Identification of two mutations (Arg611Cys and Arg611His) in the A1 loop of von Willebrand factor (vWF) responsible for type 2 von Willebrand disease with decreased platelet-dependent function of vWF. (PubMed id 7620154)1, 2, 9 Hilbert L.... Mazurier C. (1995)
    12. Characterization of the von Willebrand factor gene (VWF) in von Willebrand disease type III patients from 24 families of Swedish and Finnish origin. (PubMed id 8088787)1, 2, 9 Zhang Z.P.... Anvret M. (1994)
    13. Association between von Willebrand factor gene polymorphism and preeclampsia. (PubMed id 19021456)1, 4, 9 Sun C....Yu S. (2009)
    14. Platelet GPIbalpha, GPIV and vWF polymorphisms and fatal pre-hospital MI among middle-aged men. (PubMed id 17619827)1, 4, 9 Pellikka M....Mikkelsson J. (2007)
    15. Effect of von Willebrand factor Y/C1584 on in vivo protein level and function and interaction with ABO blood group. (PubMed id 17119126)1, 4, 9 Davies J.A....Bowen D.J. (2007)
    16. Impact of the Thr789Ala variant of the von Willebrand factor levels, on ristocetin co-factor and collagen binding capacity and its association with coronary heart disease in patients with diabetes mellitus type 2. (PubMed id 16320153)1, 4, 9 Klemm T....Paschke R. (2005)
    17. von Willebrand factor, platelets and endothelial cell interactions. (PubMed id 12871266)1, 2, 9 Ruggeri Z.M. (2003)
    18. Association studies between -1185A/G von Willebrand factor gene polymorphism and coronary artery disease. (PubMed id 12792699)1, 4, 9 Simon D....Roisenberg I. (2003)
    19. High factor VIII antigen levels increase the risk of venous thrombosis but are not associated with polymorphisms in the von Willebrand factor and factor VIII gene. (PubMed id 11722428)1, 4, 9 Kamphuisen P.W....Bertina R.M. (2001)
    20. The -1185 A/G and -1051 G/A dimorphisms in the von Willebrand factor gene promoter and risk of myocardial infarction. (PubMed id 11736957)1, 4, 9 Di Bitondo R....Winship P.R. (2001)
    21. Activation of human platelets by the membrane-expressed A1 domain of von Willebrand factor. (PubMed id 9373253)1, 2, 9 Schulte am Esch J. II...Robson S.C. (1997)
    22. Identification of a candidate missense mutation in a family with von Willebrand disease type IIC. (PubMed id 7789955)1, 2, 9 Schneppenheim R.... Zeiger B. (1995)
    23. Investigation of type IIC von Willebrand disease. (PubMed id 8011991)1, 2, 9 Uno H.... Tsuda K. (1994)
    24. Characterization of Leu777Pro and Ile865Thr type IIA von Willebrand disease mutations. (PubMed id 8123844)1, 2, 9 Lyons S.E.... Ginsburg D. (1994)
    25. Substitution of cysteine for phenylalanine 751 in mature von Willebrand factor is a novel candidate mutation in a family with type IIA von Willebrand disease. (PubMed id 8435341)1, 2, 9 Gaucher C.... Mazurier C. (1993)
    26. Identification of three candidate mutations causing type IIA von Willebrand disease using a rapid, nonradioactive, allele-specific hybridization method. (PubMed id 8338947)1, 2, 9 Inbal A.... Sadler J.E. (1993)
    27. Molecular study of von Willebrand disease: identification of potential mutations in patients with type IIA and type IIB. (PubMed id 1420817)1, 2, 9 Pietu G.... Meyer D. (1992)
    28. Germ-line mosaicism for a valine-to-methionine substitution at residue 553 in the glycoprotein Ib-binding domain of von Willebrand factor, causing type IIB von Willebrand disease. (PubMed id 1729889)1, 2, 9 Murray E.W.... Lillicrap D. (1992)
    29. Defects in type IIA von Willebrand disease: a cysteine 509 to arginine substitution in the mature von Willebrand factor disrupts a disulphide loop involved in the interaction with platelet glycoprotein Ib-IX. (PubMed id 1419804)1, 2, 9 Lavergne J.-M.... Pietu G. (1992)
    30. Analysis of the relationship of von Willebrand disease (vWD) and hereditary hemorrhagic telangiectasia and identification of a potential type IIA vWD mutation (IIe865 to Thr). (PubMed id 1673047)1, 2, 9 Iannuzzi M.C.... Ginsburg D. (1991)
    31. Molecular basis of von Willebrand disease type IIB. Candidate mutations cluster in one disulfide loop between proposed platelet glycoprotein Ib binding sequences. (PubMed id 2010538)1, 2, 9 Randi A.M.... Sadler J.E. (1991)
    32. C1272F: a novel type 2A von Willebrand's disease mutation in A1 domain; its clinical significance. (PubMed id 21592258)1, 2 Woods A.I....Lazzari M.A. (2012)
    33. New gene functions in megakaryopoiesis and platelet fo rmation. (PubMed id 22139419)1, 4 Gieger C....Soranzo N. (2011)
    34. Accumulation of gene polymorphisms related to plaque disruption and thrombosis is associated with cerebral infarction in subjects wi th type 2 diabetes. (PubMed id 19933990)1, 4 Katakami N....Yamasaki Y. (2010)
    35. Increased serum vWF and sVCAM-1 levels are associated with late or very late angiographic stent thrombosis after sirolimus-eluting s tent implantation. (PubMed id 20508517)1, 4 Jin C....Shen W.F. (2010)
    36. von Willebrand factor variant p.Arg924Gln marks an al lele associated with reduced von Willebrand factor and factor VIII levels. (PubMed id 20492463)1, 4 Hickson N....Goodeve A. (2010)
    37. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    38. Population based allele frequencies of disease associ ated polymorphisms in the Personalized Medicine Research Project. (PubMed id 20565774)1, 4 Cross D.S....McCarty C.A. (2010)
    39. Variation in the von Willebrand Factor gene is associ ated with VWF levels and with the risk of cardiovascular disease. (PubMed id 20940418)1, 4 van Schie M.C....Leebeek F.W. (2010)
    40. Common VWF exon 28 polymorphisms in African Americans affecting the VWF activity assay by ristocetin cofactor. (PubMed id 20231421)1, 4 Flood V.H....Montgomery R.R. (2010)
    41. Hemostatic gene polymorphisms in young Sardinian with non-fatal acute myocardial infarction. (PubMed id 20036902)1, 4 Musino L....Carru C. (2010)
    42. Human Variation in Alcohol Response Is Influenced by Variation in Neuronal Signaling Genes. (PubMed id 20201926)1, 4 Joslyn G....White R.L. (2010)
    43. Genetic Risk Factors for Hepatopulmonary Syndrome in Patients With Advanced Liver Disease. (PubMed id 20346360)1, 4 Roberts K.E....Fallon M.B. (2010)
    44. L-type voltage-dependent calcium channel alpha subuni t 1C is a novel candidate gene associated with secondary hyperparathyroidism: a n application of haplotype-based analysis for multiple linked single nucleotide polymorphisms. (PubMed id 20424473)1, 4 Yokoyama K....Hosoya T. (2010)
    45. Identification of fetal and maternal single nucleotid e polymorphisms in candidate genes that predispose to spontaneous preterm labor with intact membranes. (PubMed id 20452482)1, 4 Romero R....Menon R. (2010)
    46. A genetic association study of maternal and fetal can didate genes that predispose to preterm prelabor rupture of membranes (PROM). (PubMed id 20673868)1, 4 Romero R....Menon R. (2010)
    47. Microsatellite (GT)(n) repeats and SNPs in the von Willebrand factor gene promoter do not influence circulating von Willebrand factor levels under normal conditions. (PubMed id 19190813)1, 4 Daidone V....Casonato A. (2009)
    48. An assessment of the pathogenic significance of the R 924Q von Willebrand factor substitution. (PubMed id 19624459)1, 4 Berber E....Lillicrap D. (2009)
    49. The variant rs1867277 in FOXE1 gene confers thyroid c ancer susceptibility through the recruitment of USF1/USF2 transcription factors . (PubMed id 19730683)1, 4 Landa I....Robledo M. (2009)
    50. Integrative predictive model of coronary artery calci fication in atherosclerosis. (PubMed id 19948975)1, 4 McGeachie M....Ramoni M.F. (2009)
    51. A candidate gene approach to genetic prognostic factors of IgA nephropathy--a result of Polymorphism REsearch to DIstinguish genetic factors Contributing To progression of IgA Nephropathy (PREDICT-IgAN). (PubMed id 19420105)1, 4 Yamamoto R....Rakugi H. (2009)
    52. Impact of 789Ala/Ala genotype on quantitative type of von Willebrand disease. (PubMed id 18923835)1, 4 Ahmad F....Saxena R. (2008)
    53. Alpha 2A adrenergic receptor polymorphism is associated with plasma von Willebrand factor levels in a general population. (PubMed id 18600088)1, 4 Yabe M....Ikeda Y. (2008)
    54. Prothrombotic genetic variants and atherosclerosis in patients with cerebral ischemia of arterial origin. (PubMed id 18848323)1, 4 Pruissen D.M....Algra A. (2008)
    55. Polymorphisms in von Willebrand factor gene promoter influence the glucocorticoid-induced increase in von Willebrand factor: the lesson learned from Cushing syndrome. (PubMed id 18173757)1, 4 Casonato A....Scaroni C. (2008)
    56. Genetic predictors of depressive symptoms in cardiac patients. (PubMed id 18618671)1, 4 McCaffery J.M....Dube M.P. (2008)
    57. Sex differences in environmental and genetic factors for hypertension. (PubMed id 18724972)1, 4 Ruixing Y....Yuming C. (2008)
    58. Tryptic digestion of ubiquitin standards reveals an improved strategy for identifying ubiquitinated proteins by mass spectrometry. (PubMed id 17370265)1, 2 Denis N.J.... Figeys D. (2007)
    59. Von Willebrand factor 1 and factor 2 alleles (intron 40) are suitable markers for carrier detection in von Willebrand disease families in the Indian population. (PubMed id 16424652)1, 4 Trasi S....Ghosh K. (2006)
    60. Association of sixty-one non-synonymous polymorphisms in forty-one hypertension candidate genes with blood pressure variation and hypertension. (PubMed id 17137217)1, 4 Kokubo Y....Miyata T. (2006)
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    83. Two new candidate mutations in type IIA von Willebrand's disease (Arg834-->Gly, Gly846-->Arg) and one polymorphism (Tyr821-->Cys) in the A2 region of the von Willebrand factor. (PubMed id 8348943)1, 2 Donner M.... Holmberg L. (1993)
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    102. Full-length von Willebrand factor (vWF) cDNA encodes a highly repetitive protein considerably larger than the mature vWF subunit. (PubMed id 3019665)1, 2 Verweij C.L.... Pannekoek H. (1986)
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    105. Construction of cDNA coding for human von Willebrand factor using antibody probes for colony-screening and mapping of the chromosomal gene. (PubMed id 3875078)1, 2 Verweij C.L.... Pannekoek H. (1985)
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    110. Laboratory diagnosis of von Willebrand disease type 1 /2E (2A subtype IIE), type 1 Vicenza and mild type 1 caused by mutations in the D3, D4, B1-B3 and C1-C2 domains of the von Willebrand factor gene. Role of von Willebrand factor multimers and the von Willebrand factor propeptide/antigen r atio. (PubMed id 19506359)1, 9 Gadisseur A....Michiels J.J. (2009)
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    113. Evidence that differential packaging of the major platelet granule proteins von Willebrand factor and fibrinogen can support their differential release. (PubMed id 17650077)1, 9 Sehgal S. and Storrie B. (2007)
    114. Ser968Thr mutation within the A3 domain of von Willebrand factor (VWF) in two related patients leads to a defective binding of VWF to collagen. (PubMed id 11583318)1, 9 Ribba A.S....Girma J.P. (2001)
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    118. Microalbuminuria, von Willebrand factor and fibrinogen levels as markers of the severity in COPD exacerbation. (PubMed id 17622488)1, 9 Polatli M....Yenicerioglu Y. (2008)
    119. Assay of the von Willebrand factor (VWF) propeptide to identify patients with type 1 von Willebrand disease with decreased VWF survival. (PubMed id 16835381)1, 9 Haberichter S.L....Montgomery R.R. (2006)
    120. von Willebrand disease R1374C: type 2A or 2M? A challenge to the revised classification. High frequency in the northwest of Spain (Galicia). (PubMed id 16247740)1, 9 Penas N....Batlle J. (2005)
    121. Microsatellite (GT)(n) is part of the von Willebrand factor (VWF) promoter region that influences the glucocorticoid-induced increas e in VWF in Cushing's syndrome. (PubMed id 20156642)1, 9 Daidone V....Casonato A. (2010)
    122. Survival of von Willebrand factor released following DDAVP in a type 1 von Willebrand disease cohort: influence of glycosylation, proteolysis and gene mutations. (PubMed id 18449422)1, 9 Millar C.M....van Mourik J.A. (2008)
    123. An Arg760Cys mutation in the consensus sequence of the von Willebrand factor propeptide cleavage site is responsible for a new von Willebrand disease variant. (PubMed id 12393698)1, 9 Casonato A....Girolami A. (2003)
    124. Solid-phase von Willebrand factor contains a conformationally active RGD motif that mediates endothelial cell adhesion through the alpha v beta 3 receptor. (PubMed id 7505120)1, 9 Denis C....Baruch D. (1993)
    125. Intracellular cotrafficking of factor VIII and von Willebrand factor type 2N variants to storage organelles. (PubMed id 19088379)1, 9 van den Biggelaar M....Mertens K. (2009)
    126. A novel binding site for ADAMTS13 constitutively expo sed on the surface of globular VWF. (PubMed id 19587373)1, 9 Zanardelli S....Lane D.A. (2009)
    127. Multi-step binding of ADAMTS-13 to von Willebrand fac tor. (PubMed id 19765212)1, 9 Feys H.B....Sadler J.E. (2009)
    128. N-linked glycosylation of VWF modulates its interaction with ADAMTS13. (PubMed id 17975018)1, 9 McKinnon T.A....Laffan M.A. (2008)
    129. Requirements for cellular co-trafficking of factor VIII and von Willebrand factor to Weibel-Palade bodies. (PubMed id 17958741)1, 9 van den Biggelaar M....Mertens K. (2007)
    130. Rab3D and annexin A2 play a role in regulated secretion of vWF, but not tPA, from endothelial cells. (PubMed id 15257287)1, 9 Knop M....Gerke V. (2004)
    131. Vasopressin-induced von Willebrand factor secretion from endothelial cells involves V2 receptors and cAMP. (PubMed id 10880054)1, 9 Kaufmann J.E....Vischer U.M. (2000)
    132. Proteolytic resistance conferred to fibrinogen by von Willebrand factor. (PubMed id 20024497)1, 9 Tanka-Salamon A....Komorowicz E. (2010)
    133. Kynurenines and oxidative status are independently as sociated with thrombomodulin and von Willebrand factor levels in patients with end-stage renal disease. (PubMed id 19477487)1, 9 Pawlak K....Pawlak D. (2009)
    134. Changes in plasma von Willebrand factor and ADAMTS13 levels associated with left atrial remodeling in atrial fibrillation. (PubMed id 18996572)1, 9 Uemura T....Ogawa H. (2009)
    135. Role of membrane cholesterol in platelet calcium signalling in response to VWF and collagen under stasis and flow. (PubMed id 18521510)1, 9 van Lier M....Heijnen H.F. (2008)
    136. High von Willebrand factor levels increase the risk of first ischemic stroke: influence of ADAMTS13, inflammation, and genetic variability. (PubMed id 16990571)1, 9 Bongers T.N....Leebeek F.W. (2006)
    137. P-selectin binds to the D'-D3 domains of von Willebrand factor in Weibel-Palade bodies. (PubMed id 16418330)1, 9 Michaux G....Cutler D.F. (2006)
    138. An amino acid polymorphism in von Willebrand factor correlates with increased susceptibility to proteolysis by ADAMTS13. (PubMed id 14525793)1, 9 Bowen D.J. and Collins P.W. (2004)
    139. Increased levels of endothelial haemostatic markers in patients with coronary heart disease. (PubMed id 11864703)1, 9 Schumacher A....Arnesen H. (2002)
    140. Oxidative modification of von Willebrand factor by ne utrophil oxidants inhibits its cleavage by ADAMTS13. (PubMed id 19812385)1, 9 Chen J....LA^pez J.A. (2010)
    141. [Change of HIF-1alpha protein expression in the place nta bed and concentration of vWF in maternal peripheral blood of pre-eclampsia. ] (PubMed id 20197612)1, 9 Peng M....Zhou C. (2010)
    142. Identification of ADAMTS13 peptide sequences binding to von Willebrand factor. (PubMed id 19944670)1, 9 Moriki T....Murata M. (2010)
    143. Amino acid residues Arg(659), Arg(660), and Tyr(661) in the spacer domain of ADAMTS13 are critical for cleavage of von Willebrand fa ctor. (PubMed id 20075158)1, 9 Jin S.Y....Zheng X.L. (2010)
    144. Phospholipase D1 is specifically required for regulated secretion of von Willebrand factor from endothelial cells. (PubMed id 18945966)1, 9 Disse J....Gerke V. (2009)
    145. Shear-induced unfolding activates von Willebrand fact or A2 domain for proteolysis. (PubMed id 19817991)1, 9 Baldauf C....GrAoter F. (2009)
    146. Variations in the ratio between von Willebrand factor and its cleaving protease during systemic inflammation and association with severity and prognosis of organ failure. (PubMed id 19190805)1, 9 Claus R.A....LAPsche W. (2009)
    147. ADAMTS13 and von Willebrand factor and the risk of myocardial infarction in men. (PubMed id 17053057)1, 9 Chion C.K....Rosendaal F.R. (2007)
    148. Shielding of the A1 domain by the D'D3 domains of von Willebrand factor modulates its interaction with platelet glycoprotein Ib-IX-V. (PubMed id 16373331)1, 9 Ulrichts H....Deckmyn H. (2006)
    149. Impact of mutations in the von Willebrand factor A2 domain on ADAMTS13-dependent proteolysis. (PubMed id 16322474)1, 9 Hassenpflug W.A....Schneppenheim R. (2006)
    150. Exosite interactions contribute to tension-induced cleavage of von Willebrand factor by the antithrombotic ADAMTS13 metalloprotease. (PubMed id 17146059)1, 9 Gao W....Sadler J.E. (2006)
    151. Type 2N von Willebrand disease due to compound heterozygosity for R854Q and a novel R763G mutation at the cleavage site of von Willebrand factor propeptide. (PubMed id 16953269)1, 9 Hilbert L....Mazurier C. (2006)
    152. Bombay phenotype is associated with reduced plasma-VWF levels and an increased susceptibility to ADAMTS13 proteolysis. (PubMed id 15886321)1, 9 O'Donnell J.S....Laffan M.A. (2005)
    153. Increased soluble intercellular adhesion molecule-1, breast cancer and the acute phase response. (PubMed id 11914659)1, 9 Blann A.D....Baildam A.D. (2002)
    154. Force-induced cleavage of single VWFA1A2A3 tridomains by ADAMTS-13. (PubMed id 19897584)1, 9 Wu T....Zhu C. (2010)
    155. Leukocyte proteases cleave von Willebrand factor at o r near the ADAMTS13 cleavage site. (PubMed id 19541819)1, 9 Raife T.J....Zheng X.L. (2009)
    156. Levels of von Willebrand factor antigen and von Wille brand factor cleaving protease (ADAMTS13) activity predict clinical events in c hronic heart failure. (PubMed id 19718479)1, 9 Gombos T....ProhA!szka Z. (2009)
    157. Factor VIII-von Willebrand factor binding defects in autosomal recessive von Willebrand disease type Normandy and in mild hemophilia A. New insights into factor VIII-von Willebrand factor interactions. (PubMed id 19506355)1, 9 Jacquemin M. (2009)
    158. Increased plasma von Willebrand factor antigen levels but normal von Willebrand factor cleaving protease (ADAMTS13) activity in preeclampsia. (PubMed id 19190814)1, 9 Molvarec A....ProhA!szka Z. (2009)
    159. Dominant von Willebrand disease type 2A groups I and II due to missense mutations in the A2 domain of the von Willebrand factor gene : diagnosis and management. (PubMed id 19506362)1, 9 Michiels J.J. and van Vliet H.H. (2009)
    160. Nitric oxide inhibits von Willebrand factor-mediated platelet adhesion and spreading through regulation of integrin alpha(IIb)beta(3 ) and myosin light chain. (PubMed id 19765213)1, 9 Roberts W....Naseem K.M. (2009)
    161. Shear-induced interaction of platelets with von Wille brand factor results in glycoprotein Ibalpha shedding. (PubMed id 19820200)1, 9 Cheng H....Dai K. (2009)
    162. Valves of the deep venous system: an overlooked risk factor. (PubMed id 19436051)1, 9 Brooks E.G....Bovill E.G. (2009)
    163. Characterization of W1745C and S1783A: 2 novel mutati ons causing defective collagen binding in the A3 domain of von Willebrand facto r. (PubMed id 19687512)1, 9 Riddell A.F....McKinnon T.A. (2009)
    164. N1421K mutation in the glycoprotein Ib binding domain impairs ristocetin- and botrocetin-mediated binding of von Willebrand factor to platelets. (PubMed id 18637125)1, 9 Lanke E....Lethagen S. (2008)
    165. Functional impairment of von Willebrand factor in hypertrophic cardiomyopathy: relation to rest and exercise obstruction. (PubMed id 18809794)1, 9 Le Tourneau T....Jude B. (2008)
    166. Phenotype and genotype of a cohort of families historically diagnosed with type 1 von Willebrand disease in the European study, Molecular and Clinical Markers for the Diagnosis and Management of Type 1 von Willebrand Disease (MCMDM-1VWD). (PubMed id 16985174)1, 9 Goodeve A....Peake I. (2007)
    167. A common 253-kb deletion involving VWF and TMEM16B in German and Italian patients with severe von Willebrand disease type 3. (PubMed id 17371490)1, 9 Schneppenheim R....Budde U. (2007)
    168. Effect of von Willebrand disease type 2B and type 2M mutations on the susceptibility of von Willebrand factor to ADAMTS-13. (PubMed id 17087728)1, 9 Rayes J....Girma J.P. (2007)
    169. Fluvastatin inhibits regulated secretion of endothelial cell von Willebrand factor in response to diverse secretagogues. (PubMed id 17472573)1, 9 Fish R.J....Kruithof E.K. (2007)
    170. Molecular study of VWF gene from Mexican Mestizo patients with von Willebrand disease, and the finding of three new mutations. (PubMed id 17681836)1, 9 Melo-Nava B.M....Penaloza R. (2007)
    171. von Willebrand factor A1 domain can adequately substitute for A3 domain in recruitment of flowing platelets to collagen. (PubMed id 16805860)1, 9 Bonnefoy A....Hoylaerts M.F. (2006)
    172. Characterization of a core binding site for ADAMTS-13 in the A2 domain of von Willebrand factor. (PubMed id 17121983)1, 9 Wu J.J....Chung D.W. (2006)
    173. Zinc and calcium ions cooperatively modulate ADAMTS13 activity. (PubMed id 16286459)1, 9 Anderson P.J.... Sadler J.E. (2006)
    174. von Willebrand factor: two sides of a coin. (PubMed id 16102036)1, 9 Sadler J.E. (2005)
    175. Osteoprotegerin (OPG) is localized to the Weibel-Palade bodies of human vascular endothelial cells and is physically associated with von Willebrand factor. (PubMed id 15799029)1, 9 Zannettino A.C....Haynes D.R. (2005)
    176. Binding of ADAMTS13 to von Willebrand factor. (PubMed id 15824096)1, 9 Majerus E.M....Sadler J.E. (2005)
    177. Cysteine-mutations in von Willebrand factor associated with increased clearance. (PubMed id 16194200)1, 9 Schooten C.J....Denis C.V. (2005)
    178. Increased shear stress- and ristocetin-induced binding of von Willebrand factor to platelets in cord compared with adult plasma. (PubMed id 15467896)1, 9 Rehak T....Muntean W. (2004)
    179. A new candidate mutation, G1629R, in a patient with type 2A von Willebrand's disease: basic mechanisms and clinical implications. (PubMed id 15377475)1, 9 Hilbert L....Mazurier C. (2004)
    180. Crystal structure of the wild-type von Willebrand factor A1-glycoprotein Ibalpha complex reveals conformation differences with a complex bearing von Willebrand disease mutations. (PubMed id 15039442)1, 9 Dumas J.J....Mosyak L. (2004)
    181. Experimental indication for the existence of multiple Trp rotamers in von Willebrand Factor A3 domain. (PubMed id 15382239)1, 9 Hellings M....De Maeyer M. (2004)
    182. Dimerization and multimerization defects of von Willebrand factor due to mutated cysteine residues. (PubMed id 14995987)1, 9 Tjernberg P....Eikenboom J.C. (2004)
    183. C1272S: a new candidate mutation in type 2A von Willebrand disease that disrupts the disulfide loop responsible for the interaction of VWF with platelet GP Ib-IX. (PubMed id 14755371)1, 9 Penas N....Batlle J. (2004)
    184. Contributions of Asn2198, Met2199, and Phe2200 in the factor VIII C2 domain to cofactor activity, phospholipid-binding, and von Willebrand factor-binding. (PubMed id 12719775)1, 9 Lewis D.A....Ortel T.L. (2003)
    185. Successful treatment of urgent bleeding in von Willebrand disease with factor VIII/VWF concentrate (Humate-P): use of the ristocetin cofactor assay (VWF:RCo) to measure potency and to guide therapy. (PubMed id 14750934)7, 9 Gill J.C....Schwartz B.A. (2003)
    186. Structures of glycoprotein Ibalpha and its complex with von Willebrand factor A1 domain. (PubMed id 12183630)1, 9 Huizinga E.G.... Gros P. (2002)
    187. Levels of von Willebrand factor, insulin resistance syndrome, and a common vWF gene polymorphism in non-insulin-dependent (type 2) diabetes mellitus. (PubMed id 8862946)4, 9 Heywood D.M....Grant P.J. (1996)
    188. A family having type 2B von Willebrand disease with a n R1306W mutation: Severe thrombocytopenia leads to the normalization of high m olecular weight multimers. (PubMed id 19740526)1, 9 Ozeki M....Kondo N. (2010)
    189. Expression of terminal alpha2-6-linked sialic acid on von Willebrand factor specifically enhances proteolysis by ADAMTS13. (PubMed id 19965639)1, 9 McGrath R.T....O'Donnell J.S. (2010)
    190. A G-quartet oligonucleotide blocks glycoprotein Ib-me diated platelet adhesion and aggregation under flow conditions. (PubMed id 19718474)1, 9 Zhou Z....Dong J.F. (2009)
    191. Vascular endothelial growth factor (VEGF) receptor-2 tyrosine 1175 signaling controls VEGF-induced von Willebrand factor release fro m endothelial cells via phospholipase C-gamma 1- and protein kinase A-dependent pathways. (PubMed id 19570985)1, 9 Xiong Y....Luo J. (2009)
    192. Platelet adhesion to multimerin 1 in vitro: influences of platelet membrane receptors, von Willebrand factor and shear. (PubMed id 19175495)1, 9 Tasneem S....Hayward C.P. (2009)
    193. Mechanoenzymatic cleavage of the ultralarge vascular protein von Willebrand factor. (PubMed id 19498171)1, 9 Zhang X....Springer T.A. (2009)
    194. Integrin alpha(v)beta(3) on human endothelial cells binds von Willebrand factor strings under fluid shear stress. (PubMed id 18927433)1, 9 Huang J....Sadler J.E. (2009)
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    338. Von Willebrand factor and ADAMTS13: a candidate coupl e for preeclampsia pathophysiology. (PubMed id 21512165)1 Stepanian A....Veyradier A. (2011)
    339. Relationship between thrombospondin gene variations, von Willebrand factor levels and the risk of coronary heart disease in an older population. (PubMed id 21518247)1 van Loon J.E....Leebeek F.W. (2011)
    340. N-acetylcysteine reduces the size and activity of von Willebrand factor in human plasma and mice. (PubMed id 21266777)1 Chen J....LA^pez J.A. (2011)
    341. Expression of P-selectin, von Willebrand and endothel in-1 after carotid artery stenting. (PubMed id 21638248)1 Xia Z.Y....Wang L.X. (2011)
    342. New insight into the hypercoagulability of Cushing's syndrome. (PubMed id 21304226)1 Daidone V....Casonato A. (2011)
    343. Cleavage of von Willebrand factor by granzyme M destr oys its factor VIII binding capacity. (PubMed id 21909423)1 Hollestelle M.J....Bovenschen N. (2011)
    344. The role of von Willebrand factor and ADAMTS13 in the no-reflow phenomenon: after primary percutaneous coronary intervention. (PubMed id 22163125)1 Zhao B....Shi H. (2011)
    345. Von Willebrand factor and oxidative stress parameters in acute coronary syndromes. (PubMed id 21904649)1 Koprivica Z....Jakovljevic V. (2011)
    346. Genetic variation associated with plasma von Willebra nd factor levels and the risk of incident venous thrombosis. (PubMed id 21163921)1 Smith N.L....Rosendaal F.R. (2011)
    347. Unraveling the scissile bond: how ADAMTS13 recognizes and cleaves von Willebrand factor. (PubMed id 21715306)1 Crawley J.T....Lane D.A. (2011)
    348. Local elongation of endothelial cell-anchored von Wil lebrand factor strings precedes ADAMTS13 protein-mediated proteolysis. (PubMed id 21896483)1 De Ceunynck K....Vanhoorelbeke K. (2011)
    349. An apparently silent nucleotide substitution (c.7056C >T) in the von Willebrand factor gene is responsible for type 1 von Willebra nd disease. (PubMed id 21393328)1 Daidone V....Casonato A. (2011)
    350. Genetic determinants of plasma von Willebrand factor antigen levels: a target gene SNP and haplotype analysis of ARIC cohort. (PubMed id 21343614)1 Campos M....Dong J.F. (2011)
    351. Lateral self-association of VWF involves the Cys2431- Cys2453 disulfide/dithiol in the C2 domain. (PubMed id 21911836)1 Ganderton T....Hogg P.J. (2011)
    352. Value assignment of the WHO 2nd International Standar d von Willebrand factor, concentrate (09/182). (PubMed id 21831097)1 Hubbard A.R....Heath A.B. (2011)
    353. Large deletions identified in patients with von Wille brand disease using multiple ligation-dependent probe amplification. (PubMed id 21410641)1 Yadegari H....Oldenburg J. (2011)
    354. Interpretation of correlations between coagulation fa ctors FV, FVIII and vWF in normal and type 2 diabetes mellitus patients. (PubMed id 22032085)1 Dayer M.R....Alavi S.M. (2011)
    355. Endothelial von Willebrand factor regulates angiogene sis. (PubMed id 21048155)1 Starke R.D....Randi A.M. (2011)
    356. Toward an understanding of the protein interaction net work of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (2011)
    357. Role of von Willebrand factor in the haemostasis. (PubMed id 21839029)1 Peyvandi F....Baronciani L. (2011)
    358. Elevated plasma von Willebrand factor and propeptide l evels in Malawian children with malaria. (PubMed id 22125593)1 Phiri H.T....Bunn J.E. (2011)
    359. Combined analysis of three genome-wide association st udies on vWF and FVIII plasma levels. (PubMed id 21810271)1 Antoni G....Tregouet D.A. (2011)
    360. Endothelial activation markers soluble E-selectin and von Willebrand factor in primary hyperparathyroidism. (PubMed id 21471547)1 Lumachi F....Fallo F. (2011)
    361. A pH-regulated dimeric bouquet in the structure of vo n Willebrand factor. (PubMed id 21857647)1 Zhou Y.F....Springer T.A. (2011)
    362. Intracellular storage and regulated secretion of von Willebrand factor in quantitative von Willebrand disease. (PubMed id 21596755)1 Wang J.W....Eikenboom J. (2011)
    363. The relationship between levels of von Willebrand fac tor and mean platelet volume in subjects with isolated impaired fasting glucose . (PubMed id 21629201)1 Bostan F. and Coban E. (2011)
    364. Inhibition of von Willebrand factor by ARC1779 in pat ients with acute thrombotic thrombocytopenic purpura. (PubMed id 21174003)1 Jilma-Stohlawetz P....KnAPbl P. (2011)
    365. Shear stress-induced unfolding of VWF accelerates oxi dation of key methionine residues in the A1A2A3 region. (PubMed id 21917758)1 Fu X....LA^pez J.A. (2011)
    366. Differential roles of fibrinogen and von Willebrand fa ctor on clot formation and platelet adhesion in reconstituted and immune thrombo cytopenia. (PubMed id 21474661)1 Misgav M....Martinowitz U. (2011)
    367. Phylogenetic and functional analysis of histidine res idues essential for pH-dependent multimerization of von Willebrand factor. (PubMed id 21592973)1 Dang L.T....Sadler J.E. (2011)
    368. Temperature-dependence of Weibel-Palade body exocytosi s and cell surface dispersal of von Willebrand factor and its propolypeptide. (PubMed id 22096550)1 Hewlett L....Carter T. (2011)
    369. Genetic determinants of von Willebrand factor levels and activity in relation to the risk of cardiovascular disease: a review. (PubMed id 21342431)1 van Schie M.C....Leebeek F.W. (2011)
    370. Platelet glycoprotein Ib beta/IX mediates glycoprotei n Ib alpha localization to membrane lipid domain critical for von Willebrand fa ctor interaction at high shear. (PubMed id 21507943)1 Geng H....Peng Y. (2011)
    371. A conformation-sensitive monoclonal antibody against the A2 domain of von Willebrand factor reduces its proteolysis by ADAMTS13. (PubMed id 21779388)1 Zhang J....Ruan C. (2011)
    372. VWF and ADAMTS13 behavior in estradiol-treated HUVEC. (PubMed id 20958794)1 Powazniak Y....Lazzari M.A. (2011)
    373. Mechanism of von Willebrand factor scissile bond clea vage by a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13 (ADAMTS13). (PubMed id 21705658)1 Xiang Y....Lane D.A. (2011)
    374. Immunohistochemical expression of von Willebrand fact or in the preeclamptic placenta. (PubMed id 21847508)1 Parra-Cordero M....Rodrigo R. (2011)
    375. Key role of glycoprotein Ib/V/IX and von Willebrand f actor in platelet activation-dependent fibrin formation at low shear flow. (PubMed id 21037087)1 Cosemans J.M....Heemskerk J.W. (2011)
    376. Levels of von Willebrand factor and ADAMTS13 determin e clinical outcome after cardioversion for atrial fibrillation. (PubMed id 21136020)1 Freynhofer M.K....Huber K. (2011)
    377. [Von Willebrand factor and ADAMTS13 balancing primary haemostasis]. (PubMed id 21792464)1 Schneppenheim R. and Budde U. (2011)
    378. Factor VIII alters tubular organization and functiona l properties of von Willebrand factor stored in Weibel-Palade bodies. (PubMed id 21940821)1 Bouwens E.A....Mertens K. (2011)
    379. Thrombomodulin and von Willebrand factor: relation to endothelial dysfunction and disease outcome in children with acute lymphoblast ic leukemia. (PubMed id 21150180)1 Hatzipantelis E.S....Athanasiadou-Piperopoulou F. (2011)
    380. Oxidized von Willebrand factor is efficiently cleaved by serine proteases from primary granules of leukocytes: divergence from ADAMT S-13. (PubMed id 21605335)1 Lancellotti S....De Cristofaro R. (2011)
    381. The mechanism of melanoma-associated thrombin activit y and von Willebrand factor release from endothelial cells. (PubMed id 20505748)1 Kerk N....Schneider S.W. (2010)
    382. A mechanically stabilized receptor-ligand flex-bond i mportant in the vasculature. (PubMed id 20725043)1 Kim J....Springer T.A. (2010)
    383. The endothelial cell markers von Willebrand Factor (v WF), CD31 and CD34 are lost in glomerulonephritis and no longer correlate with the morphological indices of glomerular sclerosis, interstitial fibrosis, activ ity and chronicity. (PubMed id 20675279)1 Gluhovschi C....Cioca D. (2010)
    384. Impact on venous thrombosis risk of newly discovered gene variants associated with FVIII and VWF plasma levels. (PubMed id 21029358)1 Morange P.E....TrAcgouAt D.A. (2010)
    385. Pathophysiology of thrombotic thrombocytopenic purpur a. (PubMed id 20058209)1 Tsai H.M. (2010)
    386. von Willebrand factor self-association on platelet Gp Ibalpha under hydrodynamic shear: effect on shear-induced platelet activation. (PubMed id 20696943)1 Dayananda K.M....Neelamegham S. (2010)
    387. The distal carboxyterminal domains of murine ADAMTS13 influence proteolysis of platelet-decorated VWF strings in vivo. (PubMed id 20695979)1 De Maeyer B....Vanhoorelbeke K. (2010)
    388. A common variant in the Von Willebrand factor gene is associated with multiple functional consequences. (PubMed id 20941784)1 Vaidya D....Becker D.M. (2010)
    389. Efficacy of simvastatin or ezetimibe on tissue factor , von Willebrand's factor and C-reactive protein in patients with hypercholeste rolaemia. (PubMed id 20142117)1 Kostakou P....Cokkinos D.V. (2010)
    390. Comparison of plasma-derived and recombinant von Will ebrand factor by atomic force microscopy. (PubMed id 20589314)1 Seyfried B.K....Turecek P.L. (2010)
    391. Repressors NFI and NFY participate in organ-specific regulation of von Willebrand factor promoter activity in transgenic mice. (PubMed id 20431063)1 Nassiri M....Jahroudi N. (2010)
    392. Single-nucleotide polymorphisms, acute rejection, and severity of tubulitis in kidney transplantation, accounting for center-to-center variation. (PubMed id 21085059)4 Israni A....Oetting W.S. (2010)
    393. [Effect of von Willebrand factor on the biological ch aracteristics of colorectal cancer cells]. (PubMed id 20737318)1 Liu G. and Ren Y.M. (2010)
    394. Blood group significantly influences von Willebrand f actor increase and half-life after desmopressin in von Willebrand disease Vicen za. (PubMed id 20561182)1 Castaman G....Rodeghiero F. (2010)
    395. Functional variation in the arginine vasopressin 2 re ceptor as a modifier of human plasma von Willebrand factor levels. (PubMed id 20403097)1 Nossent A.Y....Eikenboom J.C. (2010)
    396. VWF pseudogene: Mimics, masks and spoils. (PubMed id 20060388)1 Kasatkar P....Ghosh K. (2010)
    397. The glycoprotein Ibalpha-von Willebrand factor intera ction induces platelet apoptosis. (PubMed id 19840363)1 Li S....Dai K. (2010)
    398. Evaluation of commercial von Willebrand factor collag en binding assays to assist the discrimination of types 1 and 2 von Willebrand disease. (PubMed id 20806123)1 Favaloro E.J. (2010)
    399. Relationships between sleep duration and von Willebra nd factor, factor VII, and fibrinogen: Whitehall II study. (PubMed id 20651279)1 Miller M.A....Cappuccio F.P. (2010)
    400. Collagen VI microfibril formation is abolished by an {alpha}2(VI) von Willebrand factor type A domain mutation in a patient with Ull rich congenital muscular dystrophy. (PubMed id 20729548)1 Tooley L.D....LamandAc S.R. (2010)
    401. A randomised pilot trial of the anti-von Willebrand f actor aptamer ARC1779 in patients with type 2b von Willebrand disease. (PubMed id 20589313)1 Jilma B....KnAPbl P. (2010)
    402. Factor VIII and platelets synergistically accelerate cleavage of von Willebrand factor by ADAMTS13 under fluid shear stress. (PubMed id 20605782)1 Skipwith C.G....Zheng X.L. (2010)
    403. The dominant-negative von Willebrand factor gene dele tion p.P1127_C1948delinsR: molecular mechanism and modulation. (PubMed id 20570857)1 Casari C....Bernardi F. (2010)
    404. Redox control of I^2-glycoprotein I-von Willebrand fac tor interaction by thioredoxin-1. (PubMed id 20979592)1 Passam F.H....Krilis S.A. (2010)
    405. Severe malaria is associated with a deficiency of von Willebrand factor cleaving protease, ADAMTS13. (PubMed id 20062916)1 LAPwenberg E.C....Dondorp A.M. (2010)
    406. Specific N-linked glycosylation sites modulate synthe sis and secretion of von Willebrand factor. (PubMed id 20418283)1 McKinnon T.A....Laffan M.A. (2010)
    407. Are integrin alpha(2)beta(1), glycoprotein Ib and vWf levels correlated with their contributions to platelet adhesion on collagen un der high-shear flow? (PubMed id 20063990)1 Jung S.M....Moroi M. (2010)
    408. Sources of variation in factor VIII, von Willebrand f actor and fibrinogen measurements: implications for detecting deficiencies and increased plasma levels. (PubMed id 20627205)1 Bach J....Hellstern P. (2010)
    409. An autoantibody epitope comprising residues R660, Y66 1, and Y665 in the ADAMTS13 spacer domain identifies a binding site for the A2 domain of VWF. (PubMed id 20032502)1 Pos W....Luken B.M. (2010)
    410. Premature termination codon mutations in the von Will ebrand factor gene are associated with allele-specific and position-dependent m RNA decay. (PubMed id 19773258)1 PlatA" M....Asselta R. (2010)
    411. Baseline von Willebrand factor plasma levels and no-r eflow phenomenon after primary percutaneous coronary intervention for ST segmen t elevation myocardial infarction. (PubMed id 19732980)1 Sgueglia G.A....Crea F. (2010)
    412. Abnormal VWF modifies megakaryocytopoiesis: studies o f platelets and megakaryocyte cultures from patients with von Willebrand disease type 2B. (PubMed id 20118404)1 Nurden P....Federici A.B. (2010)
    413. Polymorphisms and Mutations in vWF and ADAMTS13 Genes and Their Correlation With Plasma Levels of FVIII and vWF in Patients With Dee p Venous Thrombosis. (PubMed id 20682599)1 Bittar L.F....Annichino-Bizzacchi J.M. (2010)
    414. von Willebrand factor clearance does not involve prot eolysis by ADAMTS-13. (PubMed id 20704649)1 Badirou I....Denis C.V. (2010)
    415. Homozygous type 2N R854W von Willebrand factor is poo rly secreted and causes a severe von Willebrand disease phenotype. (PubMed id 20586924)1 Castaman G....Schneppenheim R. (2010)
    416. The plasma von Willebrand factor O-glycome comprises a surprising variety of structures including ABH antigens and disialosyl motifs . (PubMed id 19874459)1 Canis K....Dell A. (2010)
    417. Disulfide bond reduction of von Willebrand factor by ADAMTS-13. (PubMed id 20946172)1 Yeh H.C....Dong J.F. (2010)
    418. An integrative method for scoring candidate genes fro m association studies: application to warfarin dosing. (PubMed id 21044367)1 Tatonetti N.P....Altman R.B. (2010)
    419. The importance of vicinal cysteines, C1669 and C1670, for von Willebrand factor A2 domain function. (PubMed id 20354169)1 Luken B.M....Crawley J.T. (2010)
    420. Alterations of mRNA processing and stability as a pat hogenic mechanism in von Willebrand factor quantitative deficiencies. (PubMed id 20854374)1 Castaman G....Duga S. (2010)
    421. The mutation N528S in the von Willebrand factor (VWF) propeptide causes defective multimerization and storage of VWF. (PubMed id 20335223)1 Haberichter S.L....Schneppenheim R. (2010)
    422. [Impact of vWF gene A1381T polymorphism and ABO blood group on von Willebrand factor level in plasma]. (PubMed id 20723310)1 Yuan Z.H....Zhu P. (2010)
    423. Destabilization of the A1 domain in von Willebrand fa ctor dissociates the A1A2A3 tri-domain and provokes spontaneous binding to glyc oprotein Ibalpha and platelet activation under shear stress. (PubMed id 20498367)1 Auton M....Cruz M.A. (2010)
    424. Validation of a rapid test (VWF-LIA) for the quantita tive determination of von Willebrand factor antigen in type 1 von Willebrand di sease diagnosis within the European multicenter study MCMDM-1VWD. (PubMed id 20650506)1 Castaman G....Rodeghiero F. (2010)
    425. Comparative study of coagulation and thrombin generat ion in the portal and jugular plasma of patients with cirrhosis. (PubMed id 20806106)1 Delahousse B....Gruel Y. (2010)
    426. A human MAP kinase interactome. (PubMed id 20936779)1 Bandyopadhyay S....Ideker T. (2010)
    427. mRNA levels of CD31, CD144, CD146 and von Willebrand factor do not serve as surrogate markers for circulating endothelial cells. (PubMed id 20589320)1 Strijbos M.H....Lamers C.H. (2010)
    428. A cluster of mutations in the D3 domain of von Willeb rand factor correlates with a distinct subgroup of von Willebrand disease: type 2A/IIE. (PubMed id 20351307)1 Schneppenheim R....Budde U. (2010)
    429. Relevance of chloride binding to von Willebrand facto r in type 2B von Willebrand disease patients. (PubMed id 19943880)1 Baronciani L....de Cristofaro R. (2010)
    430. Functional characterization of a 13-bp deletion (c.-1 522_-1510del13) in the promoter of the von Willebrand factor gene in type 1 von Willebrand disease. (PubMed id 20696945)1 Othman M....Lillicrap D. (2010)
    431. Thrombospondin-1 and ADAMTS13 competitively bind to V WF A2 and A3 domains in vitro. (PubMed id 20705333)1 Wang A....Ruan C. (2010)
    432. Neuropeptide delivery to the brain: a von Willebrand factor signal peptide to direct neuropeptide secretion. (PubMed id 20701764)1 de Backer M.W....Adan R.A. (2010)
    433. A novel alanine or threonine 789 to proline mutation causing type 2N von Willebrand's disease when inherited homozygously or heteroz ygously with arginine 854 to glutamine mutation. (PubMed id 20491956)1 Enayat M.S....Hill F.G. (2010)
    434. Rapid activation of endothelial cells enables Plasmod ium falciparum adhesion to platelet-decorated von Willebrand factor strings. (PubMed id 19897581)1 Bridges D.J....Craig A. (2010)
    435. Novel associations of multiple genetic loci with plas ma levels of factor VII, factor VIII, and von Willebrand factor: The CHARGE (Co horts for Heart and Aging Research in Genome Epidemiology) Consortium. (PubMed id 20231535)1 Smith N.L.... C.J. (2010)
    436. A novel deletion mutation is recurrent in von Willebr and disease types 1 and 3. (PubMed id 19372260)1 Sutherland M.S....Keeney S. (2009)
    437. Genetic alteration of the D2 domain abolishes von Wil lebrand factor multimerization and trafficking into storage. (PubMed id 19192112)1 Haberichter S.L....Gill J.C. (2009)
    438. A novel type 2A von Willebrand factor mutation (V1499E) associated with variable clinical expression. (PubMed id 19346881)1 van den Heuvel E....Versteegh F.G. (2009)
    439. ADAMTS13 bound to endothelial cells exhibits enhanced cleavage of von Willebrand factor. (PubMed id 19729451)1 Vomund A.N. and Majerus E.M. (2009)
    440. Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)
    441. Structural specializations of A2, a force-sensing dom ain in the ultralarge vascular protein von Willebrand factor. (PubMed id 19470641)1 Zhang Q....Springer T.A. (2009)
    442. Heyde's syndrome without a decrease in large von Will ebrand factor multimers: a case of intestinal bleedings reversed by valve repla cement in a patient with aortic stenosis. (PubMed id 19350125)1 Undas A....Sadowski J. (2009)
    443. Platelet morphological changes in 2 patients with von Willebrand disease type 3 caused by large homozygous deletions of the von Will ebrand factor gene. (PubMed id 19608674)1 Nurden P....Federici A.B. (2009)
    444. ADAMTS-13 cleaves long von Willebrand factor multimeric strings anchored to endothelial cells in the absence of flow, platelets or conformation-altering chemicals. (PubMed id 18983500)1 Turner N....Moake J. (2009)
    445. Fluid shear induces conformation change in human bloo d protein von Willebrand factor in solution. (PubMed id 19289057)1 Singh I....Neelamegham S. (2009)
    446. Expression of 14 von Willebrand factor mutations iden tified in patients with type 1 von Willebrand disease from the MCMDM-1VWD study . (PubMed id 19566550)1 Eikenboom J....Goodeve A. (2009)
    447. [Polymorphism of DXS15, CA13, CA22 loci in Guangdong normal population]. (PubMed id 20030949)1 Chu Y.X....Yu C.S. (2009)
    448. Kinetic study of von Willebrand factor self-aggregati on induced by ristocetin. (PubMed id 19647361)1 Di Stasio E....De Cristofaro R. (2009)
    449. A +220 GATA motif mediates basal but not endotoxin-re pressible expression of the von Willebrand factor promoter in Hprt-targeted tra nsgenic mice. (PubMed id 19496923)1 Liu J....Aird W.C. (2009)
    450. Type 2A (IIH) von Willebrand disease is due to mutati ons that affect von Willebrand factor multimerization. (PubMed id 19422453)1 Baronciani L....Mannucci P.M. (2009)
    451. von Willebrand factor cleaved from endothelial cells by ADAMTS13 remains ultralarge in size. (PubMed id 19682236)1 Jin S.Y....Zheng X.L. (2009)
    452. Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. (PubMed id 19159218)2 Chen R.... Zou H. (2009)
    453. Novel missense mutation c.2685G>C (p.Q895H) in VWF gene associated with very low levels of VWF mRNA. (PubMed id 18712522)1 Cabrera N....Aznar J.A. (2009)
    454. Dominant von Willebrand disease type 2M and 2U are va riable expressions of one distinct disease entity caused by loss-of-function mu tations in the A1 domain of the von Willebrand factor gene. (PubMed id 19506361)1 Gadisseur A....Michiels J.J. (2009)
    455. von Willebrand factor assembly and secretion. (PubMed id 19630761)1 Sadler J.E. (2009)
    456. N-Glycans of ADAMTS13 modulate its secretion and von Willebrand factor cleaving activity. (PubMed id 18981290)1 Zhou W. and Tsai H.M. (2009)
    457. Inflammation, hemostasis, and the risk of kidney function decline in the Atherosclerosis Risk in Communities (ARIC) Study. (PubMed id 19110358)1 Bash L.D....Astor B.C. (2009)
    458. Laboratory diagnosis and molecular basis of mild von Willebrand disease type 1. (PubMed id 19506353)1 Michiels J.J....van Vliet H.H. (2009)
    459. Rapid molecular diagnosis of von Willebrand disease b y direct sequencing. Detection of 12 novel putative mutations in VWF gene. (PubMed id 19277422)1 Corrales I....Vidal F. (2009)
    460. Autosomal recessive von Willebrand disease type 1 or 2 due to homozygous or compound heterozygous mutations in the von Willebrand fa ctor gene. A single center experience on molecular heterogeneity and laboratory features in 12 families. (PubMed id 19506356)1 Castaman G....Rodeghiero F. (2009)
    461. Impaired glucose tolerance and endothelial damage, as assessed by levels of von Willebrand factor and circulating endothelial cells, following acute myocardial infarction. (PubMed id 20021313)1 Jessani S.S....Lip G.Y. (2009)
    462. Genetic analysis of Alzheimer's disease in the Uppsala Longitudinal Study of Adult Men. (PubMed id 19141999)4 Giedraitis V....Glaser A. (2009)
    463. Altered megakaryocytopoiesis in von Willebrand type 2 B disease. (PubMed id 19630816)1 Nurden A.T....Nurden P. (2009)
    464. An Alu-mediated novel large deletion is the most frequent cause of type 3 von Willebrand disease in Hungary. (PubMed id 18665926)1 Mohl A....Schneppenheim R. (2008)
    465. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
    466. Characterization of a novel mutation in the von Willebrand factor propeptide in a distinct subtype of recessive von Willebrand disease. (PubMed id 18690339)1 Lanke E....Lethagen S. (2008)
    467. Platelet-VWF complexes are preferred substrates of ADAMTS13 under fluid shear stress. (PubMed id 17901248)1 Shim K....Sadler J.E. (2008)
    468. Effects of von Willebrand factor concentration and platelet collision on shear-induced platelet activation. (PubMed id 18612539)1 Gao Z....Ruan C. (2008)
    469. Type 2B von Willebrand disease associated with the release of platelet agglutinates from megakaryocytes in the bone marrow. (PubMed id 18776767)1 Slayton W.B....Friedman K.D. (2008)
    470. Relationship between von Willebrand factor, cholesterol and triglycerides in non-diabetic subjects. (PubMed id 18042361)1 Lippi G....Franchini M. (2008)
    471. Aquaporin 2 gene variations, risk of venous thrombosis and plasma levels of von Willebrand factor and factor VIII. (PubMed id 18515885)1 Nossent A.Y....Eikenboom J.C. (2008)
    472. Magnesium maintains endothelial integrity, up-regulates proteolysis of ultra-large von Willebrand factor, and reduces platelet aggregation under flow conditions. (PubMed id 18327408)1 Dong J.F....Kent T.A. (2008)
    473. Prevalence of type 2b 'Malmo/New York' von Willebrand disease in Italy: the role of von Willebrand factor gene conversion. (PubMed id 18315546)1 Baronciani L....Mannucci P.M. (2008)
    474. Inflammatory cytokines inhibit ADAMTS13 synthesis in hepatic stellate cells and endothelial cells. (PubMed id 18433458)1 Cao W.J....Zheng X.L. (2008)
    475. Prothrombotic gene variation in patients with large and small vessel disease. (PubMed id 18622144)4 Pruissen D.M....Algra A. (2008)
    476. Persistent factor VIII-dependent factor X activation on endothelial cells is independent of von Willebrand factor. (PubMed id 18388497)1 Brinkman H.J....Mertens K. (2008)
    477. Basal secretion of von Willebrand factor from human endothelial cells. (PubMed id 18344423)1 Giblin J.P....Hannah M.J. (2008)
    478. Hepatitis C virus infection protein network. (PubMed id 18985028)1 de Chassey B....Lotteau V. (2008)
    479. Antihemostatic activity of human granzyme B mediated by cleavage of von Willebrand factor. (PubMed id 18577516)1 Buzza M.S....Bird P.I. (2008)
    480. Thrombospondin-1 in von Willebrand factor function. (PubMed id 18855616)1 Bonnefoy A. and Hoylaerts M.F. (2008)
    481. Beta3 integrin haplotype influences gene regulation and plasma von Willebrand factor activity. (PubMed id 18045606)1 Payne K.E....Carter A.M. (2008)
    482. Influence of a GT repeat element on shear stress responsiveness of the VWF gene promoter. (PubMed id 18485092)1 Hough C....Lillicrap D. (2008)
    483. Extracellular control of VWF multimer size and thiol-disulfide exchange. (PubMed id 18503632)1 Luken B.M. (2008)
    484. The effect of exercise on von Willebrand factor and ADAMTS-13 in individuals with type 1 and type 2B von Willebrand disease. (PubMed id 17922807)1 Stakiw J....James P. (2008)
    485. von Willebrand factor: evidence for variable clearance in vivo according to Y/C1584 phenotype and ABO blood group. (PubMed id 17949477)1 Davies J.A....Bowen D.J. (2008)
    486. Is VWF R924Q a benign polymorphism, a marker of a null allele or a factor VIII-binding defect? The debate continues with results from the UKHCDO VWD study. (PubMed id 18841300)1 Lester W....Collins P. (2008)
    487. Hemostatic and inflammatory risk factors for intracerebral hemorrhage in a pooled cohort. (PubMed id 18535282)1 Sturgeon J.D....Cushman M. (2008)
    488. The membrane-proximal intermolecular disulfide bonds in glycoprotein Ib influence receptor binding to von Willebrand factor. (PubMed id 18647229)1 Mo X....Li R. (2008)
    489. Evidence that high von Willebrand factor and low ADAMTS-13 levels independently increase the risk of a non-fatal heart attack. (PubMed id 18194418)1 Crawley J.T....Lowe G.D. (2008)
    490. Type 2B von Willebrand disease in seven individuals from three different families: phenotypic and genotypic characterization. (PubMed id 17598021)1 Szanto T....Vanhoorelbeke K. (2007)
    491. Platelet activation and von Willebrand factor binding to platelets in newborn infants with central venous lines. (PubMed id 17159336)1 Schmugge M....Rand M.L. (2007)
    492. Effects of toll-like receptor-4 gene polymorphisms on soluble P-selectin and von Willebrand factor levels in hypercholesterolemic patients. (PubMed id 17849054)1 Di Nisio M....Porreca E. (2007)
    493. Surface-dependent expression in the platelet GPIb binding domain within human von Willebrand factor studied by atomic force microscopy. (PubMed id 17010412)1 Kang I....Marchant R.E. (2007)
    494. Investigation of von Willebrand factor gene mutations in Korean von Willebrand disease patients. (PubMed id 18094571)1 Song J....Song K.S. (2007)
    495. Characterization of the interaction between von Willebrand factor and osteoprotegerin. (PubMed id 17723135)1 Shahbazi S....Christophe O.D. (2007)
    496. Autosomal recessive von Willebrand disease associated with compound heterozygosity for a novel nonsense mutation (2908 del C) and the missense mutation C2362F: definite evidence for the non-penetrance of the C2362F mutation. (PubMed id 17109387)1 Castaman G....Rodeghiero F. (2007)
    497. Efficiency of von Willebrand factor-mediated targeting of interleukin-8 into Weibel-Palade bodies. (PubMed id 17883593)1 Bierings R....van Mourik J.A. (2007)
    498. A mechanism to safeguard platelet adhesion under high shear flow: von Willebrand factor-glycoprotein Ib and integrin alphabeta-collagen interactions make complementary, collagen-type-specific contributions to adhesion. (PubMed id 17408410)1 Moroi M. and Jung S.M. (2007)
    499. Von Willebrand disease - phenotype versus genotype: deficiency versus disease. (PubMed id 17490730)1 Lillicrap D. (2007)
    500. Von Willebrand factor: looking back and looking forward. (PubMed id 17597991)1 Ruggeri Z.M. (2007)
    501. Haemostatic changes and acquired activated protein C resistance in normal pregnancy. (PubMed id 17890957)1 Mahieu B....Van der Planken M. (2007)
    502. The mutational spectrum of type 1 von Willebrand disease: Results from a Canadian cohort study. (PubMed id 17190853)1 James P.D....Lillicrap D. (2007)
    503. Soluble plasma-derived von Willebrand factor assembles to a haemostatically active filamentous network. (PubMed id 17393012)1 Barg A....Schneider S.W. (2007)
    504. A role for von Willebrand factor in Streptococcus sanguis-induced platelet activation. (PubMed id 18064343)1 McNicol A....Israels S.J. (2007)
    505. Von Willebrand factor short sequence repeat locus 2 (intron 40) consists of three polymorphic subloci. (PubMed id 17159339)1 Othman M....O'Shaughnessy D.F. (2007)
    506. Microfluidic reveals generation of platelet-strings on tumor-activated endothelium. (PubMed id 17721608)1 Goerge T....Schneider S.W. (2007)
    507. Plasma intercellular adhesion molecule-1 and von Willebrand factor in primary graft dysfunction after lung transplantation. (PubMed id 17908278)1 Covarrubias M....Christie J.D. (2007)
    508. Impaired dimerization of von Willebrand factor subunit due to mutation A2801D in the CK domain results in a recessive type 2A subtype IID von Willebrand disease. (PubMed id 16676067)1 Hommais A....Ribba A.S. (2006)
    509. Solution structure of human von Willebrand factor studied using small angle neutron scattering. (PubMed id 17052980)1 Singh I....Neelamegham S. (2006)
    510. ADAMTS13 substrate recognition of von Willebrand factor A2 domain. (PubMed id 16221672)1 Zanardelli S....Lane D.A. (2006)
    511. The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (2006)
    512. The finished DNA sequence of human chromosome 12. (PubMed id 16541075)2 Scherer S.E.... Gibbs R.A. (2006)
    513. Molecular mapping of the chloride-binding site in von Willebrand factor (VWF): energetics and conformational effects on the VWF/ADAMTS-13 interaction. (PubMed id 16899464)1 De Cristofaro R....Mannucci P.M. (2006)
    514. A single high-affinity binding site for von Willebrand factor in collagen III, identified using synthetic triple-helical peptides. (PubMed id 16912226)1 Lisman T....Farndale R.W. (2006)
    515. The interaction of von Willebrand factor-A1 domain with collagen: mutation G1324S (type 2M von Willebrand disease) impairs the conformational change in A1 domain induced by collagen. (PubMed id 16420575)1 Morales L.D....Cruz M.A. (2006)
    516. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    517. p130Cas: a versatile scaffold in signaling networks. (PubMed id 16581250)1 Defilippi P....Cabodi S. (2006)
    518. Mutations C1157F and C1234W of von Willebrand factor cause intracellular retention with defective multimerization and secretion. (PubMed id 16409464)1 Hommais A....Ribba A.S. (2006)
    519. Impact of fibronectin assembly on platelet thrombus formation in response to type I collagen and von Willebrand factor. (PubMed id 16735600)1 Cho J. and Mosher D.F. (2006)
    520. R924Q substitution encoded within exon 21 of the von Willebrand factor gene related to mild bleeding phenotype. (PubMed id 16894469)1 Casais P....Lazzari M.A. (2006)
    521. Physical stress as a model to study variations in ADAMTS-13 activity, von Willebrand factor level and platelet activation. (PubMed id 16634765)1 Claus R.A....Hilberg T. (2006)
    522. Usefulness of von Willebrand factor in cardiac allograft vasculopathy: preliminary experience. (PubMed id 17098004)1 Chamorro C.I....Salvador A. (2006)
    523. Paratope determination of the antithrombotic antibody 82D6A3 based on the crystal structure of its complex with the von Willebrand factor A3-domain. (PubMed id 16314412)1 Staelens S....Deckmyn H. (2006)
    524. Recombinant factor VIII and factor VIII-von Willebrand factor complex do not present danger signals for human dendritic cells. (PubMed id 16953272)1 Pfistershammer K....Reipert B.M. (2006)
    525. Dynamic force spectroscopy of glycoprotein Ib-IX and von Willebrand factor. (PubMed id 15764659)1 Arya M....Anvari B. (2005)
    526. Theoretical structural explanation for Group I and Group II, type 2A von Willebrand disease mutations. (PubMed id 15842374)1 O'Brien L.A....Lillicrap D. (2005)
    527. A tripeptide mimetic of von Willebrand factor residues 981-983 enhances platelet adhesion to fibrinogen by signaling through integrin alpha(IIb)beta3. (PubMed id 15946218)1 Litjens P.E....Akkerman J.W. (2005)
    528. Cleavage of ultra-large von Willebrand factor by ADAMTS-13 under flow conditions. (PubMed id 16102037)1 Dong J.F. (2005)
    529. Platelets adhered to endothelial cell-bound ultra-large von Willebrand factor strings support leukocyte tethering and rolling under high shear stress. (PubMed id 15748247)1 Bernardo A....Dong J.F. (2005)
    530. Plasma von Willebrand factor antigen levels in non-small cell lung cancer patients. (PubMed id 15816602)1 Martini F....Roselli M. (2005)
    531. Enzymatically active ADAMTS13 variants are not inhibited by anti-ADAMTS13 autoantibodies: a novel therapeutic strategy? (PubMed id 16203734)1 Zhou W....Tsai H.M. (2005)
    532. Re-establishment of VWF-dependent Weibel-Palade bodies in VWD endothelial cells. (PubMed id 15331450)1 Haberichter S.L....Montgomery R.R. (2005)
    533. Decreased plasma concentration of von Willebrand factor antigen (VWF:Ag) in patients with glycogen storage disease type Ia. (PubMed id 16435187)1 Muhlhausen C....Santer R. (2005)
    534. Evaluation of the von Willebrand factor Y1584C polymorphism as a potential risk factor for bleeding in patients receiving anticoagulant treatment with vitamin K antagonists. (PubMed id 15842375)1 Tjernberg P....Reitsma P.H. (2005)
    535. Endothelial microparticles induce formation of platelet aggregates via a von Willebrand factor/ristocetin dependent pathway, rendering them resistant to dissociation. (PubMed id 15946221)1 Jy W....Ahn Y.S. (2005)
    536. Recombinant CUB-1 domain polypeptide inhibits the cleavage of ULVWF strings by ADAMTS13 under flow conditions. (PubMed id 16141351)1 Tao Z....Dong J.F. (2005)
    537. Differential kinetics of cell surface loss of von Willebrand factor and its propolypeptide after secretion from Weibel-Palade bodies in living human endothelial cells. (PubMed id 15831502)1 Hannah M.J....Carter T. (2005)
    538. The von Willebrand factor self-association is modulated by a multiple domain interaction. (PubMed id 15748246)1 Ulrichts H....Deckmyn H. (2005)
    539. Von Willebrand factor antigen levels in Behcet disease. (PubMed id 15849757)1 Beyan E....Beyan C. (2005)
    540. The platelet glycoprotein Ib-von Willebrand factor interaction activates the collagen receptor alpha2beta1 to bind collagen: activation-dependent conformational change of the alpha2-I domain. (PubMed id 15514009)1 Cruz M.A....Lopez J.A. (2005)
    541. The proximal carboxyl-terminal domains of ADAMTS13 determine substrate specificity and are all required for cleavage of von Willebrand factor. (PubMed id 15975930)1 Ai J....Zheng X.L. (2005)
    542. Gain of von Willebrand factor-binding function by mutagenesis of a species-conserved residue within the leucine-rich repeat region of platelet glycoprotein Ibalpha. (PubMed id 15933060)1 Peng Y....Lopez J.A. (2005)
    543. The prevalence of the cysteine1584 variant of von Willebrand factor is increased in type 1 von Willebrand disease: co-segregation with increased susceptibility to ADAMTS13 proteolysis but not clinical phenotype. (PubMed id 15755288)2 Bowen D.J....Hill F.G. (2005)
    544. Integrins and Src: dynamic duo of adhesion signaling. (PubMed id 16005629)1 Shattil S.J. (2005)
    545. Plasma von Willebrand factor and arterial aging. (PubMed id 15842373)1 Vischer U.M....Benetos A. (2005)
    546. Cleavage of von Willebrand factor by ADAMTS-13 on endothelial cells. (PubMed id 14727255)1 Lopez J.A. and Dong J.F. (2004)
    547. Von Willebrand factor present in fibrillar collagen enhances platelet adhesion to collagen and collagen-induced platelet aggregation. (PubMed id 15102023)1 Bernardo A....Dong J.F. (2004)
    548. The human plasma proteome: a nonredundant list developed by combination of four separate sources. (PubMed id 14718574)1 Anderson N.L....Lobley A. (2004)
    549. ATP augments von Willebrand factor-dependent shear-induced platelet aggregation through Ca2+-calmodulin and myosin light chain kinase activation. (PubMed id 15087444)1 Oury C....Hoylaerts M.F. (2004)
    550. P-selectin anchors newly released ultralarge von Willebrand factor multimers to the endothelial cell surface. (PubMed id 14630802)1 Padilla A....Dong J.F. (2004)
    551. [Study of C1423T polymorphism of the von Willebrand factor-cleaving protease gene in Chinese Han population] (PubMed id 15182579)1 Gao W.Q....Ruan C.G. (2004)
    552. von Willebrand factor C1C2 domain is involved in platelet adhesion to polymerized fibrin at high shear rate. (PubMed id 14604963)1 Keuren J.F....Lindhout T. (2004)
    553. Fibrin polymerization is crucial for thrombin generation in platelet-rich plasma in a VWF-GPIb-dependent process, defective in Bernard-Soulier syndrome. (PubMed id 14717981)1 Beguin S....Hemker H.C. (2004)
    554. Platelet and von Willebrand factor interactions at the vessel wall. (PubMed id 15029268)1 Ruggeri Z.M. and Ruggeri Z.M. (2004)
    555. A novel type 2A von Willebrand factor mutation located at the last nucleotide of exon 26 (3538G>A) causes skipping of 2 nonadjacent exons. (PubMed id 15226181)1 James P.D....Lillicrap D. (2004)
    556. Surface-exposed hemophilic mutations across the factor VIII C2 domain have variable effects on stability and binding activities. (PubMed id 15471879)1 Spiegel P.C....Stoddard B.L. (2004)
    557. VWF73, a region from D1596 to R1668 of von Willebrand factor, provides a minimal substrate for ADAMTS-13. (PubMed id 14512308)1 Kokame K....Miyata T. (2004)
    558. Molecular modeling of the von Willebrand factor A2 Domain and the effects of associated type 2A von Willebrand disease mutations. (PubMed id 15322948)1 Sutherland J.J....Weaver D.F. (2004)
    559. Crystal structure of the von Willebrand factor A domain of human capillary morphogenesis protein 2: an anthrax toxin receptor. (PubMed id 15079089)1 Lacy D.B.... Collier R.J. (2004)
    560. von Willebrand factor, ADAMTS-13, and thrombotic thrombocytopenic purpura. (PubMed id 14727254)1 Moake J.L. (2004)
    561. Functional proteomics mapping of a human signaling pathway. (PubMed id 15231748)1 Colland F....Gauthier J.M. (2004)
    562. Factor VIII and von Willebrand factor changes during normal pregnancy and puerperium. (PubMed id 14517489)1 Sanchez-Luceros A....Lazzari M.A. (2003)
    563. Von Willebrand factor. (PubMed id 12579041)1 Ruggeri Z.M. (2003)
    564. von Willebrand factor (VWF)-dependent human platelet activation: porcine VWF utilizes different transmembrane signaling pathways than does thrombin to activate platelets, but both require protein phosphatase function. (PubMed id 12871509)1 Song S....Lazarus A.H. (2003)
    565. Collagen-binding mode of vWF-A3 domain determined by a transferred cross-saturation experiment. (PubMed id 12447349)1 Nishida N....Shimada I. (2003)
    566. von Willebrand factor stimulates thrombin-induced exposure of procoagulant phospholipids on the surface of fibrin-adherent platelets. (PubMed id 12871466)1 Briede J.J....Lindhout T. (2003)
    567. Mural thrombus generation in type 2A and 2B von Willebrand disease under flow conditions. (PubMed id 12393671)1 Sugimoto M....Yoshioka A. (2003)
    568. Intercellular calcium communication regulates platelet aggregation and thrombus growth. (PubMed id 12668663)1 Nesbitt W.S....Jackson S.P. (2003)
    569. Activation of pp125FAK by type 2B recombinant von Willebrand factor binding to platelet GPIb at a high shear rate occurs independently of alpha IIb beta 3 engagement. (PubMed id 12543870)1 Mekrache M....Baruch D. (2003)
    570. Molecular defects in type 3 von Willebrand disease: updated results from 40 multiethnic patients. (PubMed id 12737944)1 Baronciani L....Mannucci P.M. (2003)
    571. Aspects of hydrodynamic shear regulating shear-induced platelet activation and self-association of von Willebrand factor in suspension. (PubMed id 12456504)1 Shankaran H....Neelamegham S. (2003)
    572. Hypoxia and altered platelet behavior influence von W illebrand factor multimeric composition in secondary pulmonary hypertension. (PubMed id 14507115)1 CaramurA_ L.H....Lopes A.A. (2003)
    573. Critical roles for the COOH-terminal NITY and RGT sequences of the integrin beta3 cytoplasmic domain in inside-out and outside-in signaling. (PubMed id 12860973)1 Xi X....Du X. (2003)
    574. Anti-heavy-chain monoclonal antibodies directed to the acidic regions of the factor VIII molecule inhibit the binding of factor VIII to phospholipids and von Willebrand factor. (PubMed id 12958606)1 Raut S....Barrowcliffe T.W. (2003)
    575. The NFY transcription factor inhibits von Willebrand factor promoter activation in non-endothelial cells through recruitment of histone deacetylases. (PubMed id 12511565)1 Peng Y. and Jahroudi N. (2003)
    576. Interaction between von Willebrand factor and glycoprotein Ib activates Src kinase in human platelets: role of phosphoinositide 3-kinase. (PubMed id 12393736)1 Wu Y....Ozaki Y. (2003)
    577. Von Willebrand factor targets IL-8 to Weibel-Palade bodies in an endothelial cell line. (PubMed id 12729795)1 Romani de Wit T....van Mourik J.A. (2003)
    578. Mapping the collagen-binding site in the von Willebrand factor-A3 domain. (PubMed id 12582178)1 Romijn R.A....Huizinga E.G. (2003)
    579. Analysis of intracellular storage and regulated secretion of 3 von Willebrand disease-causing variants of von Willebrand factor. (PubMed id 12791651)1 Michaux G....Cutler D.F. (2003)
    580. Platelet aggregation by membrane-expressed A1 domains of von Willebrand Factor is dependent on residues Asp 560 and Gly 561. (PubMed id 12646253)1 Schulte am Esch J....Cruz M.A. (2003)
    581. The mucin-like macroglycopeptide region of glycoprotein Ibalpha is required for cell adhesion to immobilized von Willebrand factor (VWF) under flow but not for static VWF binding. (PubMed id 12362242)1 Li C.Q....Lopez J.A. (2002)
    582. Structural basis of von Willebrand factor activation by the snake toxin botrocetin. (PubMed id 12121649)1 Fukuda K....Liddington R.C. (2002)
    583. Reconstitution of adhesive properties of human platelets in liposomes carrying both recombinant glycoproteins Ia/IIa and Ib alpha under flow conditions: specific synergy of receptor-ligand interactions. (PubMed id 12070018)1 Nishiya T....Ikeda Y. (2002)
    584. Recombinant von Willebrand factor-insight into structure and function through infusion studies in animals with severe von Willebrand disease. (PubMed id 11992244)1 Schwarz H.P....Turecek P.L. (2002)
    585. Binding site on human von Willebrand factor of bitiscetin, a snake venom-derived platelet aggregation inducer. (PubMed id 12069583)1 Matsui T....Titani K. (2002)
    586. Regulation of glycoprotein Ib-IX-von Willebrand factor interaction by cAMP-dependent protein kinase-mediated phosphorylation at Ser 166 of glycoprotein Ib(beta). (PubMed id 12361948)1 Bodnar R.J....Du X. (2002)
    587. Shear-dependent morphology of von Willebrand factor bound to immobilized collagen. (PubMed id 11877281)1 Novak L....Harsfalvi J. (2002)
    588. Shear-induced von Willebrand factor-mediated platelet surface translocation of the CD40 ligand. (PubMed id 12676191)1 Tamura N....Goto S. (2002)
    589. Selective and signal-dependent recruitment of membrane proteins to secretory granules formed by heterologously expressed von Willebrand factor. (PubMed id 12006654)1 Blagoveshchenskaya A.D....Cutler D.F. (2002)
    590. Identification of the regulatory elements of the human von Willebrand factor for binding to platelet GPIb. Importance of structural integrity of the regions flanked by the CYS1272-CYS1458 disulfide bond. (PubMed id 11943773)1 Nakayama T....Saito H. (2002)
    591. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    592. Factor VIIa induced release of von Willebrand factor from human umbilical vein endothelial cells by a tyrosine kinase dependent pathway. (PubMed id 12083486)1 Brown S.A....Collins P.W. (2002)
    593. Site-directed mutagenesis of platelet glycoprotein Ib alpha demonstrating residues involved in the sulfation of tyrosines 276, 278, and 279. (PubMed id 12036871)1 Tait A.S....Chong B.H. (2002)
    594. Molecular genetics of type 2 von Willebrand disease. (PubMed id 11843298)1 Fressinaud E....Meyer D. (2002)
    595. Expression of von Willebrand's factor, CD34, CD31, and vascular endothelial growth factor in uterine leiomyomas. (PubMed id 12215337)1 Poncelet C....Darai E. (2002)
    596. Crystal structure of the platelet glycoprotein Ibalpha N-terminal domain reveals an unmasking mechanism for receptor activation. (PubMed id 12087105)1 Uff S.... Emsley J. (2002)
    597. The role of von Willebrand factor in platelet function. (PubMed id 11992236)1 de Groot P.G. (2002)
    598. Endothelial von Willebrand factor recruits platelets to atherosclerosis-prone sites in response to hypercholesterolemia. (PubMed id 12036879)1 Theilmeier G....Hoylaerts M.F. (2002)
    599. Functional self-association of von Willebrand factor during platelet adhesion under flow. (PubMed id 11756664)1 Savage B....Ruggeri Z.M. (2002)
    600. Association of the 3467C>T mutation (T1156M) in the von Willebrand's factor gene with dominant type 1 von Willebrand's disease. (PubMed id 11529461)4 Casana P....Aznar J.A. (2001)
    601. Selective inactivation of Von Willebrand factor binding to glycoprotein IIb/IIIa and to inhibitor monoclonal antibody 9 by site-directed mutagenesis. (PubMed id 11920243)1 Jumilly A.L....Girma J.P. (2001)
    602. Thrombin-mediated in vitro processing of pro-von Willebrand factor. (PubMed id 11776313)1 Varadi K....Schwarz H.P. (2001)
    603. Coagulation products and their uses. (PubMed id 10938981)7 Shord S.S. and Lindley C.M. (2000)
    604. Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. (PubMed id 10737800)1 Dias Neto E....Simpson A.J.G. (2000)
    605. Mapping the glycoprotein Ib-binding site in the von willebrand factor A1 domain. (PubMed id 10764791)1 Cruz M.A....Handin R.I. (2000)
    606. Angiotensin II receptor subtypes in the skeletal muscle vasculature of patients with severe congestive heart failure. (PubMed id 11056094)1 Malendowicz S.L....LeJemtel T.H. (2000)
    607. Phosphoinositide 3-kinase forms a complex with platel et membrane glycoprotein Ib-IX-V complex and 14-3-3zeta. (PubMed id 10887121)1 Munday A.D....Mitchell C.A. (2000)
    608. Localization of disulfide bonds in the cystine knot domain of human von Willebrand factor. (PubMed id 10831592)1 Katsumi A....Sadler J.E. (2000)
    609. Evidence of increased angiogenesis in patients with acute myeloid leukemia. (PubMed id 10607717)1 Hussong J.W....Shami P.J. (2000)
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    611. A simple immunomagnetic protocol for the selective isolation and long-term culture of human dermal microvascular endothelial cells. (PubMed id 9570915)1 Richard L....Detmar M. (1998)
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    613. The complete cDNA sequence and structural polymorphism of the polypeptide chain of porcine submaxillary mucin. (PubMed id 9407109)1 Eckhardt A.E....Hill R.L. (1997)
    614. Propolypeptide of von Willebrand factor is a novel ligand for very late antigen-4 integrin. (PubMed id 9079671)1 Isobe T....Takagi J. (1997)
    615. Crystal structure of NMC-4 fab anti-von Willebrand factor A1 domain. (PubMed id 9215757)1 Celikel R....Ruggeri Z.M. (1997)
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    618. Identification of three tyrosine residues of glycoprotein Ib alpha with distinct roles in von Willebrand factor and alpha-thrombin binding. (PubMed id 7721887)1 Marchese P....Ruggeri Z.M. (1995)
    619. The affinity and stoichiometry of binding of human factor VIII to von Willebrand factor. (PubMed id 7756647)1 Vlot A.J....Sixma J.J. (1995)
    620. Conserved linkage of neurotrophin-3 and von Willebrand factor on mouse chromosome 6. (PubMed id 8318738)1 Barrow L.L....Meisler M.H. (1993)
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    624. Selective inactivation of the Arg-Gly-Asp-Ser (RGDS) binding site in von Willebrand factor by site-directed mutagenesis. (PubMed id 1737795)1 Beacham D.A....Handin R.I. (1992)
    625. 150-kD von Willebrand factor binding protein extracted from human vascular subendothelium is type VI collagen. (PubMed id 2056120)1 Rand J.H....Potter B.J. (1991)
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    633. von Willebrand factor contaminating porcine factor VI II concentrate (Hyate:C) causes platelet aggregation. (PubMed id 2942172)7 Altieri D.C....Mannucci P.M. (1986)
    634. von Willebrand factor, now cloned. (PubMed id 3489483)1 Lynch D.C....Ruggeri Z.M. (1986)
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    636. von Willebrand's disease characterized by increased ristocetin sensitivity and the presence of all von Willebrand factor multimers in plasma. (PubMed id 3488775)1 Holmberg L....Nilsson I.M. (1986)
    637. Isolation and characterization of a collagen binding domain in human von Willebrand factor. (PubMed id 3490481)1 Pareti F.I....Ruggeri Z.M. (1986)
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    639. Factor VIII/von Willebrand factor in subendothelium mediates platelet adhesion. (PubMed id 3872140)1 Turitto V.T....Sussman I.I. (1985)
    640. Studies with a murine monoclonal antibody that abolishes ristocetin-induced binding of von Willebrand factor to platelets: additional evidence in support of GPIb as a platelet receptor for von Willebrand factor. (PubMed id 6336654)1 Coller B.S....Sullivan C.A. (1983)
    641. Potentiation of wheat germ agglutinin aggregation of platelets by von Willebrand protein and by a 116,000 molecular weight tryptic f ragment. (PubMed id 20218000)1 Martin S.E....Marder V.J. (1983)
    642. Immunolocalization of von Willebrand protein in Weibel-Palade bodies of human endothelial cells. (PubMed id 6754744)1 Wagner D.D....Marder V.J. (1982)
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    647. Intravenous DDAVP and factor VIII-von Willebrand factor concentrate for the treatment and prophylaxis of bleedings in patients With von Willebrand disease type 1, 2 and 3. (PubMed id 17164493)9 Michiels J.J....Budde U. (2007)
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    654. Comparison of different assays for von Willebrand factor in hemodialysis patients. (PubMed id 11356999)9 Borawski J....Mysliwiec M. (2000)
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    657. Platelet-vessel wall interactions in thrombosis and restenosis role of von Willebrand factor. (PubMed id 9490916)9 Hoylaerts M.F. (1997)
    658. Significance of plasma von Willebrand factor level and von Willebrand factor-cleaving protease activity in patients with chronic renal diseases. (PubMed id 18272039)9 Lu G.Y....Ruan C.G. (2008)
    659. An update on the von Willebrand factor collagen binding assay: 21 years of age and beyond adolescence but not yet a mature adult. (PubMed id 18175279)9 Favaloro E.J. (2007)
    660. Acquired von Willebrand syndromes: clinical features, aetiology, pathophysiology, classification and management. (PubMed id 11686107)9 Michiels J.J....Berneman Z. (2001)
    661. Desmopressin therapy to assist the functional identification and characterisation of von Willebrand disease: Differential utility from combining two (VWF:CB and VWF:RCo) von Willebrand factor activity assays? (PubMed id 19064279)9 Favaloro E.J....Baker R. (2009)
    662. A novel von Willebrand factor mutation (I1372S) associated with type 2B-like von Willebrand disease: an elusive phenotype and a difficult diagnosis. (PubMed id 18064311)9 Casonato A....Pagnan A. (2007)
    663. Content and functional activity of von Willebrand factor in apheresis plasma. (PubMed id 15260819)9 Burnouf T....Goudemand J. (2004)
    664. Population differences in von Willebrand factor levels affect the diagnosis of von Willebrand disease in African-American women. (PubMed id 11343385)9 Miller C.H....Evatt B.L. (2001)
    665. Laboratory diagnosis of von Willebrand disorder (vWD) and monitoring of DDAVP therapy: efficacy of the PFA-100 and vWF:CBA as combined diagnostic strategies. (PubMed id 11260278)9 Favaloro E.J....Koutts J. (2001)
    666. Platelet aggregation induced by a monoclonal antibody to the A1 domain of von Willebrand factor. (PubMed id 9573016)9 Depraetere H....Baruch D. (1998)
    667. Abnormal collagen binding activity of 2A von Willebrand factor: evidence that the defect depends only on the lack of large multimers. (PubMed id 9016863)9 Casonato A....Girolami A. (1997)
    668. Requirements of von Willebrand factor to protect factor VIII from inactivation by activated protein C. (PubMed id 8630390)9 Koppelman S.J....Sixma J.J. (1996)
    669. Measurement of von Willebrand factor-specific mRNA and release and storage of von Willebrand factor from endothelial cells of dogs with type-I von Willebrand's disease. (PubMed id 8599517)9 Meinkoth J.H. and Meyers K.M. (1995)
    670. Multimer size dependence of von Willebrand factor bin ding to crosslinked or noncrosslinked fibrin. (PubMed id 2107883)9 Ribes J.A. and Francis C.W. (1990)
    671. A shorter von Willebrand factor survival in O blood g roup subjects explains how ABO determinants influence plasma von Willebrand fac tor. (PubMed id 18245665)9 Gallinaro L....Casonato A. (2008)
    672. 2B or not 2B? Disparate discrimination of functional VWF discordance using different assay panels or methodologies may lead to success or failure in the early identification of type 2B VWD. (PubMed id 17721617)9 Favaloro E.J....Marsden K. (2007)
    673. Classification and characterization of hereditary types 2A, 2B, 2C, 2D, 2E, 2M, 2N, and 2U (unclassifiable) von Willebrand disease. (PubMed id 17000885)9 Michiels J.J....van Vliet H. (2006)
    674. Measurement of von Willebrand factor activity: relative effects of ABO blood type and race. (PubMed id 14521604)9 Miller C.H....Evatt B. (2003)
    675. Critical independent regions in the VWF propeptide and mature VWF that enable normal VWF storage. (PubMed id 12393513)9 Haberichter S.L....Montgomery R.R. (2003)
    676. Comparative study on collagen-binding enzyme-linked immunosorbent assay and ristocetin cofactor activity assays for detection of functional activity of von Willebrand factor. (PubMed id 11992238)9 Turecek P.L....Schwarz H.P. (2002)
    677. Discrimination of von Willebrands disease (VWD) subtypes: direct comparison of von Willebrand factor:collagen binding assay (VWF:CBA) with monoclonal antibody (MAB) based VWF-capture systems. (PubMed id 11057847)9 Favaloro E.J....Hertzberg M. (2000)
    678. von Willebrand factor: measuring its antigen or funct ion? Correlation between the level of antigen, activity, and multimer size usin g various detection systems. (PubMed id 9700852)9 Fischer B.E....Dorner F. (1998)
    679. Collagen covalently immobilized onto plastic surfaces simplifies measurement of von Willebrand factor-collagen binding activity. (PubMed id 9619734)9 Fischer B.E....Dorner F. (1998)
    680. Binding of the von Willebrand factor A1 domain to histone. (PubMed id 9219327)9 Ward C.M....Berndt M.C. (1997)
    681. Involvement of calcium and G proteins in the acute release of tissue-type plasminogen activator and von Willebrand factor from cultured human endothelial cells. (PubMed id 9351387)9 van den Eijnden-Schrauwen Y....Emeis J.J. (1997)
    682. Von Willebrand factor abnormalities in IgA nephropathy. (PubMed id 9075127)9 Bertaglia G....Gambaro G. (1997)
    683. Clearance of normal and type 2A von Willebrand factor in the rat. (PubMed id 8781425)9 Stoddart J.H....Lynch D.C. (1996)
    684. Relatively increased von Willebrand factor activity after off-pump coronary artery bypass graft surgery. (PubMed id 17200766)9 Lo B....Fijnheer R. (2007)
    685. von Willebrand factor and its propeptide: the influence of secretion and clearance on protein levels and the risk of venous thrombosis. (PubMed id 17059421)9 Nossent A.Y....Eikenboom H.C. (2006)
    686. Correction of a murine model of von Willebrand disease by gene transfer. (PubMed id 16638935)9 Pergolizzi R.G....Crystal R.G. (2006)
    687. Comparative analysis and classification of von Willebrand factor/factor VIII concentrates: impact on treatment of patients with von Willebrand disease. (PubMed id 16977573)9 Budde U....Muller H.G. (2006)
    688. In vitro studies, pharmacokinetic studies and clinical use of a high purity double virus inactivated FVIII/VWF concentrate (Immunate) in the treatment of von Willebrand disease. (PubMed id 15213847)9 Ver Elst K.M....Leebeek F.W. (2004)
    689. A comparative in vitro evaluation of six von Willebrand factor concentrates. (PubMed id 15086321)9 Lethagen S....Hillarp A. (2004)
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    691. Standardisation of von Willebrand Factor in therapeut ic concentrates: calibration of the 1st International Standard for von Willebra nd Factor concentrate (00/514). (PubMed id 12353064)9 Hubbard A.R....Mazurier C. (2002)
    692. Mapping and functional studies of two alloantibodies developed in patients with type 3 von Willebrand disease. (PubMed id 10739386)9 Tout H....Girma J.P. (2000)
    693. Von Willebrand factor: molecular size and functional activity. (PubMed id 8767102)9 Furlan M. (1996)
    694. Purification and characterization of human platelet von Willebrand factor. (PubMed id 7819071)9 Williams S.B....Gralnick H.R. (1994)
    695. Role of von Willebrand factor in vascular disease. (PubMed id 19151843)9 Paulinska P....Jilma B. (2009)
    696. A highly-sensitive plasma von Willebrand factor ristocetin cofactor (VWF:RCo) activity assay by flow cytometry. (PubMed id 18031294)9 Chen D....Owen W.G. (2008)
    697. von Willebrand factor standards for plasma and concentrate testing. (PubMed id 16862526)9 Hubbard A.R. (2006)
    698. Von Willebrand factor can support platelet aggregation via interaction with activated GPIIb-IIIa and GPIb. (PubMed id 15745313)9 Naimushin Y.A. and Mazurov A.V. (2004)
    699. The role of the D1 domain of the von Willebrand factor propeptide in multimerization of VWF. (PubMed id 12176890)9 Rosenberg J.B....Montgomery R.R. (2002)
    700. Function of von Willebrand factor in children with diarrhea-associated hemolytic-uremic syndrome (D+ HUS). (PubMed id 11446662)9 Sutor A.H....Zimmerhackl L.B. (2001)
    701. Standardisation of factor VIII and von Willebrand factor in plasma: calibration of the 4th International Standard (97/586). (PubMed id 11341497)9 Hubbard A.R....Barrowcliffe T.W. (2001)
    702. In vivo regulation of von willebrand factor synthesis: von Willebrand factor production in endothelial cells after lung transplantation between normal pigs and von Willebrand factor-deficient pigs. (PubMed id 10591687)9 Brouland J.P....Drouet L. (1999)
    703. von Willebrand factor (vWf) as a plasma marker of endothelial activation in diabetes: improved reliability with parallel determination of the vWf propeptide (vWf:AgII). (PubMed id 9869174)9 Vischer U.M....Ingerslev J. (1998)
    704. Acquired von Willebrand disease caused by an autoantibody selectively inhibiting the binding of von Willebrand factor to collagen. (PubMed id 7949092)9 van Genderen P.J....van Vliet H.H. (1994)
    705. A new variant of von Willebrand's disease (type I Padua): doublet-organized plasma von Willebrand factor oligomers in the presence of all size multimers. (PubMed id 7890268)9 Casonato A....Girolami A. (1994)
    706. Quantitative and qualitative assessment of plasma von Willebrand factor in classic Kaposi's sarcoma. (PubMed id 8432918)9 Hodak E....Inbal A. (1993)
    707. The association of factor VIII with von Willebrand factor. (PubMed id 1903173)9 Lollar P. (1991)
    708. Limitations of the ristocetin cofactor assay in measu rement of von Willebrand factor function. (PubMed id 19694940)9 Flood V.H....Montgomery R.R. (2009)
    709. Identification of type 1 von Willebrand disease patients with reduced von Willebrand factor survival by assay of the VWF propeptide in the European study: molecular and clinical markers for the diagnosis and management of type 1 VWD (MCMDM-1VWD). (PubMed id 18344424)9 Haberichter S.L....Montgomery R.R. (2008)
    710. Laboratory diagnosis and monitoring of desmopressin treatment of von Willebrand's disease by flow cytometry. (PubMed id 18055988)9 Giannini S....Gresele P. (2007)
    711. Characterization of recessive severe type 1 and 3 von Willebrand Disease (VWD), asymptomatic heterozygous carriers versus bloodgroup O-related von Willebrand factor deficiency, and dominant type 1 VWD. (PubMed id 16959681)9 Michiels J.J....van Vliet H. (2006)
    712. Comparative response of plasma VWF in dogs to up-regulation of VWF mRNA by interleukin-11 versus Weibel-Palade body release by desmopressin (DDAVP). (PubMed id 12649145)9 Olsen E.H....Nichols T.C. (2003)
    713. Linkage analysis of factor VIII and von Willebrand factor loci as quantitative trait loci. (PubMed id 12911592)9 De Visser M.C....Bertina R.M. (2003)
    714. Molecular diagosis of von Willebrand disease. (PubMed id 12430915)9 Ruan C. (2002)
    715. Type 2M von Willebrand disease variant characterized by abnormal von willebrand factor multimerization. (PubMed id 11150026)9 Casonato A....Girolami A. (2001)
    716. Control of von Willebrand factor multimer size by thrombospondin-1. (PubMed id 11413189)9 Xie L....Hogg P.J. (2001)
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    718. Detection of von Willebrand disorder and identification of qualitative von Willebrand factor defects. Direct comparison of commercial ELISA-based von Willebrand factor activity options. (PubMed id 11026108)9 Favaloro E.J. (2000)
    719. Collagen-bound von Willebrand factor has reduced affinity for factor VIII. (PubMed id 10212199)9 Bendetowicz A.V....Gilbert G.E. (1999)
    720. Abnormalities in circulating von Willebrand factor and survival in pulmonary hypertension. (PubMed id 9688017)9 Lopes A.A....Bydlowski S.P. (1998)
    721. Molecular genetics of von Willebrand disease. (PubMed id 9599650)9 Mazurier C....Meyer D. (1998)
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    723. Molecular basis of von Willebrand disease. (PubMed id 8800502)9 Mazurier C. and Meyer D. (1996)
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    725. A multispecies enzyme-linked immunosorbent assay for von Willebrand's factor. (PubMed id 1583394)9 Benson R.E....Dodds W.J. (1992)
    726. Studies on anti-von Willebrand factor (vWF) monoclonal antibody NMC-4, which inhibits both ristocetin- and botrocetin-induced vWF binding to platelet glycoprotein Ib. (PubMed id 1984791)9 Fujimura Y....Fukui H. (1991)
    727. Discrepant increase in factor VIII: C and von Willebrand factor after DDAVP infusion in a patient with variant von Willebrand's disease. (PubMed id 1768767)9 Casonato A....Girolami . (1991)
    728. High von Willebrand factor concentration compensates a relative adhesion defect in uremic blood. (PubMed id 2156581)9 Zwaginga J.J....Sixma J.J. (1990)
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    731. Linear relationship between ADAMTS13 activity and platelet dynamics even before severe thrombocytopenia. (PubMed id 18988930)9 Song J....Choi J.R. (2008)
    732. Loss of factor VIII and von Willebrand factor activities during cold storage of whole blood is reversed by rewarming. (PubMed id 16751138)9 Refaai M.A....Eby C.S. (2006)
    733. Serum von Willebrand factor, matrix metalloproteinase-9, and vascular endothelial growth factor levels predict the onset of cerebral vasospasm after aneurysmal subarachnoid hemorrhage. (PubMed id 12383357)9 McGirt M.J....Laskowitz D.T. (2002)
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    735. Abnormalities of von Willebrand factor are also part of the prothrombotic state of Cushing's syndrome. (PubMed id 10357009)9 Casonato A....Girolami A. (1999)
    736. Inverse immunostaining pattern for synthesized versus endocytosed alpha-granule proteins in human bone marrow megakaryocytes. (PubMed id 9674731)9 de LarouziA"re V....Cramer E. (1998)
    737. Relation of endothelium, thrombogenesis, and hemorheology in systemic hypertension to ethnicity and left ventricular hypertrophy. (PubMed id 9416937)9 Lip G.Y....Beevers D.G. (1997)
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    739. Lack of effect of 1-desamino-8-D-arginine vasopressin on direct adhesion of platelets to collagen. (PubMed id 7690994)9 Ghosh S. and Rao A.K. (1993)
    740. A monoclonal antibody (NMC-VIII/10) to factor VIII light chain recognizing Glu1675-Glu1684 inhibits factor VIII binding to endogenous von Willebrand factor in human umbilical vein endothelial cells. (PubMed id 1390241)9 Shima M....Fukui H. (1992)
    741. Aprotinin increases release of von Willebrand factor in cultured human umbilical vein endothelial cells. (PubMed id 1381524)9 Havel M.P....Wolner E. (1992)
    742. DDAVP-induced release of von Willebrand factor from e ndothelial cells in vitro: the effect of plasma and blood cells. (PubMed id 2108732)9 Hashemi S....Ganz P.R. (1990)
    743. Plasma von Willebrand factor and thrombomodulin as markers of vascular disorders in patients undergoing regular hemodialysis therapy. (PubMed id 2162087)9 Tomura S....Marumo F. (1990)
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    745. Biomarkers of endothelial dysfunction are elevated and related to prognosis in chronic heart failure patients with diabetes but not in those without diabetes. (PubMed id 18343722)9 Kistorp C....Hildebrandt P. (2008)
    746. Evidence from limited proteolysis of a ristocetin-ind uced conformational change in human von Willebrand factor that promotes its bin ding to platelet glycoprotein Ib-IX-V. (PubMed id 17977030)9 Kang M....Kermode J.C. (2008)
    747. Acute myocardial infarction as a systemic prothrombotic condition evidenced by increased von Willebrand factor protein over ADAMTS13 activity in coronary and systemic circulation. (PubMed id 18810578)9 Horii M....Saito Y. (2008)
    748. Macrophages contribute to the cellular uptake of von Willebrand factor and factor VIII in vivo. (PubMed id 18559674)9 van Schooten C.J....Lenting P.J. (2008)
    749. Simulation of platelet adhesion and aggregation regulated by fibrinogen and von Willebrand factor. (PubMed id 18217141)9 Mori D....Yamaguchi T. (2008)
    750. VWF protects FVIII from endocytosis by dendritic cells and subsequent presentation to immune effectors. (PubMed id 16985172)9 Dasgupta S....Lacroix-Desmazes S. (2007)
    751. Cerebral venous thrombosis and plasma concentrations of factor VIII and von Willebrand factor: a case control study. (PubMed id 17189302)9 Bugnicourt J.M....Godefroy O. (2007)
    752. The cooperative activity between the carboxyl-terminal TSP1 repeats and the CUB domains of ADAMTS13 is crucial for recognition of von Willebrand factor under flow. (PubMed id 17540842)9 Zhang P....Zheng X.L. (2007)
    753. Haemorheological, platelet and endothelial indices in relation to global measures of cardiovascular risk in hypertensive patients: a substudy of the Anglo-Scandinavian Cardiac Outcomes Trial. (PubMed id 17222171)9 Spencer C.G....Lip G.Y. (2007)
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    755. Treatment of von Willebrand disease. (PubMed id 15662613)9 Rodeghiero F. and Castaman G. (2005)
    756. Ability of different glycoprotein IIb-IIIa ligands to support platelet aggregation induced by activating antibody CRC54. (PubMed id 16097942)9 Naimushin Y.A. and Mazurov A.V. (2005)
    757. Association of the antagonism of von Willebrand factor but not fibrinogen by platelet alphaIIbbeta3 antagonists with prolongation of bleeding time. (PubMed id 16150045)9 Aoki T....Mutoh S. (2005)
    758. Biological and genetic factors influencing plasma factor VIII levels in a healthy family population: results from the Stanislas cohort. (PubMed id 15606554)9 Morange P.E....Juhan-Vague I. (2005)
    759. Clearance of fibrinogen and von Willebrand factor in serial double-filtration plasmapheresis. (PubMed id 12874818)9 Lin S.M....Chiu H.C. (2003)
    760. Induction of megakaryocytes to synthesize and store a releasable pool of human factor VIII. (PubMed id 14675082)9 Wilcox D.A....Montgomery R.R. (2003)
    761. Distinct and concerted functions of von Willebrand factor and fibrinogen in mural thrombus growth under high shear flow. (PubMed id 12393609)9 Matsui H....Yoshioka A. (2002)
    762. Insulin resistance is accompanied by increased von Willebrand factor levels in nondiabetic women: a study of offspring of type 2 diabetic subjects compared to offspring of nondiabetic subjects. (PubMed id 12190891)9 Foss C.H....Damsgaard E.M. (2002)
    763. Plasma vascular endothelial growth factor, soluble VE GF receptor FLT-1, and von Willebrand factor in glaucoma. (PubMed id 12386093)9 Lip P.L....Lip G.Y. (2002)
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    765. Interleukin 11 significantly increases plasma von Willebrand factor and factor VIII in wild type and von Willebrand disease mouse models. (PubMed id 11154224)9 Denis C.V....Wagner D.D. (2001)
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    768. Morphological differences between GPIb antibody-induced and shear stress-induced platelet aggregates. (PubMed id 11155036)9 Nomura S....Kambayashi J. (2000)
    769. Partial inhibition of nitric oxide synthase primes the stimulated pathway of vWF-secretion in man. (PubMed id 10580169)9 Pernerstorfer T....Jilma B. (2000)
    770. A new animal model of thrombophilia confirms that high plasma factor VIII levels are thrombogenic. (PubMed id 10064011)9 Kawasaki T....Hoylaerts M.F. (1999)
    771. von Willebrand factor, tissue plasminogen activator, and dehydroepiandrosterone sulphate predict cardiovascular death in a 10 year follow up of survivors of acute myocardial infarction. (PubMed id 9875107)9 Jansson J.H....Johnson O. (1998)
    772. Heparins designed to specifically inhibit platelet interactions with von Willebrand factor. (PubMed id 8598091)9 Sobel M....Harris R.B. (1996)
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    774. DDAVP infusion in haemophilia A carriers: different behaviour of plasma factor VIII and von Willebrand factor. (PubMed id 8874865)9 Casonato A....Girolami A. (1996)
    775. SK&F 96365 inhibits intracellular Ca2+ pumps and raises cytosolic Ca2+ concentration without production of nitric oxide and von Willebrand factor. (PubMed id 8985595)9 Iouzalen L....David-Dufilho M. (1996)
    776. Changes in factor VIII binding capacity of von Willebrand factor and factor VIII coagulant activity in two patients with type 2N von Willebrand disease after hemostatic treatment and during pregnancy. (PubMed id 8854570)9 Nishino M....Yoshioka A. (1996)
    777. Preferential antagonism of the interactions of the integrin alpha IIb beta 3 with immobilized glycoprotein ligands by snake-venom RGD (Arg-Gly-Asp) proteins. Evidence supporting a functional role for the amino acid residues flanking the tripeptide RGD in determining the inhibitory properties of snake-venom RGD proteins. (PubMed id 7529494)9 Lu X....Rahman S. (1994)
    778. The relationship of arterial compliance with endothelial-derived proteins of the hemostatic system. (PubMed id 8445990)9 Smith D.H....Weber M.A. (1993)
    779. Functional analysis of the Arg91Gln substitution in the factor VIII binding domain of von Willebrand factor demonstrates variable phenotypic expression. (PubMed id 8115998)9 Lavergne J.M....Meyer D. (1993)
    780. Heparin binding assay of von Willebrand factor (vWF) in plasma milieu--evidence of the importance of the multimerization degree of v WF. (PubMed id 8322266)9 de Romeuf C. and Mazurier C. (1993)
    781. Tissue-type plasminogen activator and von Willebrand factor plasma levels as markers of endothelial involvement in patients with Raynaud's phenomenon. (PubMed id 1459797)9 Marasini B....Agostoni A. (1992)
    782. Influence of dry heat treatment and anticoagulant on coupling of fibrinogen and fibronectin to von Willebrand factor in normal plasma. (PubMed id 1333636)9 EllegAYrd K.H....Ingerslev J. (1992)
    783. Shear stress-induced von Willebrand factor binding to platelet glycoprotein Ib initiates calcium influx associated with aggregation. (PubMed id 1611079)9 Chow T.W....Kroll M.H. (1992)
    784. Recombinant von Willebrand factor Arg578-->Gln. A type IIB von Willebrand disease mutation affects binding to glycoprotein Ib but not to collagen or heparin. (PubMed id 1400429)9 Randi A.M....Sadler J.E. (1992)
    785. Molecular characterization of a unique von Willebrand disease variant. A novel mutation affecting von Willebrand factor/factor VIII interaction. (PubMed id 1906877)9 Cacheris P.M....Ginsburg D. (1991)
    786. Variability in the fibrinogen and von Willebrand factor content of cryoprecipitate. Implications for reducing donor exposure. (PubMed id 2327369)9 Hoffman M. and Jenner P. (1990)
    787. Evidence for a von Willebrand factor defect in factor VIII binding in three members of a family previously misdiagnosed mild haemophilia A and haemophilia A carriers: consequences for therapy and genetic counselling. (PubMed id 2124499)9 Mazurier C....Goudemand M. (1990)
    788. Effects of carvedilol or metoprolol on PAI-1, tPA-mas s concentration or Von Willebrand factor in chronic heart failure--a COMET subs tudy. (PubMed id 19762071)9 Boman K....Poole-Wilson P. (2010)
    789. Evaluation of von Willebrand factor activity in facto r VIII/von Willebrand factor concentrates with the automated von Willebrand fac tor: activity IL test. (PubMed id 20179578)9 Mori F....Farina C. (2010)
    790. Establishment of reference intervals for von Willebra nd factor antigen and eight coagulation factors in a Korean population followin g the Clinical and Laboratory Standards Institute guidelines. (PubMed id 20160641)9 Jang J.H....Kim S.H. (2010)
    791. Potential role of enhanced cytokinemia and plasma inh ibitor on the decreased activity of plasma ADAMTS13 in patients with alcoholic hepatitis: relationship to endotoxemia. (PubMed id 19094193)9 Ishikawa M....Fukui H. (2010)
    792. New developments in lung endothelial heterogeneity: V on Willebrand factor, P-selectin, and the Weibel-Palade body. (PubMed id 20490980)9 Ochoa C.D....Stevens T. (2010)
    793. The active conformation of von Willebrand factor in p atients with thrombotic thrombocytopenic purpura in remission. (PubMed id 19548905)9 Groot E....Lenting P.J. (2009)
    794. [Study on dynamic changes in coagulability and von Wi llebrand factor and its correlation with prognosis of cardiopulmonary resuscita tion] (PubMed id 20042140)9 Zhou J.X....Cheng R.N. (2009)
    795. Bleeding symptoms and laboratory correlation in patie nts with severe von Willebrand disease. (PubMed id 19473418)9 Metjian A.D....Konkle B.A. (2009)
    796. Endothelial haemostatic markers in members of families with familial combined hyperlipidemia. (PubMed id 18417194)9 KarA!sek D....NovotnA1 D. (2009)
    797. Response to DDAVP in children with von Willebrand disease type 2. (PubMed id 19404524)9 Schneppenheim R....Schrum J. (2009)
    798. Fibrinogen and von Willebrand factor mediated platelet adhesion to polystyrene under flow conditions. (PubMed id 18854129)9 Zhang M....Horbett T.A. (2008)
    799. ADAMTS-13 activity in the presence of elevated von Willebrand factor levels as a novel mechanism of residual platelet reactivity in high risk coronary patients on antiplatelet treatment. (PubMed id 18603284)9 Marcucci R....Gori A.M. (2008)
    800. Prospective evaluation of coagulopathy in multiple myeloma patients before, during and after various chemotherapeutic regimens. (PubMed id 18241919)9 van Marion A.M....Leebeek F.W. (2008)
    801. Clinicopathologic correlation of retinal angiomatous proliferation. (PubMed id 19064845)9 Monson D.M....Wilson D.J. (2008)
    802. Effect of adsorbed von Willebrand factor and fibrinogen on platelet interactions with synthetic materials under flow conditions. (PubMed id 17969019)9 Wu Y....Horbett T.A. (2008)
    803. Cerebral endothelial injury in elderly patients with severe head injury measured by serum thrombomodulin and von Willebrand factor. (PubMed id 17895610)9 Yokota H....Yamamoto Y. (2007)
    804. Increased von Willebrand factor over decreased ADAMTS13 activity may contribute to the development of liver disturbance and multiorgan failure in patients with alcoholic hepatitis. (PubMed id 17331163)9 Matsuyama T....Fukui H. (2007)
    805. The relationship between ABO groups and subgroups, factor VIII and von Willebrand factor. (PubMed id 17296574)9 Sousa N.C....Barjas-Castro M.L. (2007)
    806. Relationship between the binding sites for von Willebrand factor, phospholipid, and human factor VIII C2 inhibitor alloantibodies within the factor VIII C2 domain. (PubMed id 17483075)9 Nogami K....Yoshioka A. (2007)
    807. Factor VIII inhibitors: role of von Willebrand factor on the uptake of factor VIII by dendritic cells. (PubMed id 18078399)9 Kaveri S.V....Lacroix-Desmazes S. (2007)
    808. Effects of blood pressure on the prothrombotic risk in 1235 patients with non-valvular atrial fibrillation. (PubMed id 17005711)9 Varughese G.I....Lip G.Y. (2007)
    809. Increased circulating endothelial cells in acute heart failure: comparison with von Willebrand factor and soluble E-selectin. (PubMed id 16185922)9 Chong A.Y....Blann A.D. (2006)
    810. Effect of sedation on soluble P-selectin levels, coagulation and myocardial damage following a coronary intervention. (PubMed id 16700848)9 Yazici M....Sagkan O. (2006)
    811. Hemostasis and fibrinolysis in non-diabetic overweight and obese men and women. Is there still a role for leptin? (PubMed id 16914603)9 Mertens I....Van Gaal L.F. (2006)
    812. Plasma ADAMTS13 activity may predict early adverse events in living donor liver transplantation: observations in 3 cases. (PubMed id 16528712)9 Ko S....Nakajima Y. (2006)
    813. [The association of von Willebrand factor and von Willebrand factor-cleaving protease in systemic lupus erythematosus] (PubMed id 16624087)9 Lu G.Y....Ruan C.G. (2006)
    814. Regulated release of VWF and FVIII and the biologic implications. (PubMed id 16470522)9 Haberichter S.L....Montgomery R.R. (2006)
    815. The angiopoietin/Tie-2 system in proliferative sickle retinopathy: relation to vascular endothelial growth factor, its soluble receptor Flt-1 and von Willebrand factor, and to the effects of laser treatment. (PubMed id 15965157)9 Mohan J.S....Lip G.Y. (2005)
    816. High pulse pressure and nondipping circadian blood pressure in patients with coronary artery disease: Relationship to thrombogenesis and endothelial damage/dysfunction. (PubMed id 15691624)9 Lee K.W....Lip G.Y. (2005)
    817. Angiogenic factors in atrial fibrillation: a possible role in thrombogenesis? (PubMed id 16179272)9 Freestone B....Lip G.Y. (2005)
    818. Reassessment of ABO blood group, sex, and age on laboratory parameters used to diagnose von Willebrand disorder: potential influence on the diagnosis vs the potential association with risk of thrombosis. (PubMed id 16416741)9 Favaloro E.J....Favaloro J.W. (2005)
    819. Circulating endothelial cells in acute ischaemic stroke. (PubMed id 16270621)9 Nadar S.K....Blann A.D. (2005)
    820. Type 2N von Willebrand disease. (PubMed id 16131435)9 Mazurier C. and Hilbert L. (2005)
    821. Identification of the amino acid residues of the platelet glycoprotein Ib (GPIb) essential for the von Willebrand factor binding by clustered charged-to-alanine scanning mutagenesis. (PubMed id 14757772)9 Shimizu A....Hirai M. (2004)
    822. Factor VIII expression in liver disease. (PubMed id 14961153)9 Hollestelle M.J....van Mourik J.A. (2004)
    823. Relationships between factor VIII:Ag and factor VIII in recombinant and plasma-derived factor VIII concentrates. (PubMed id 15357771)9 Lin Y....Ofosu F.A. (2004)
    824. Plasma levels of von Willebrand factor regulate ADAMTS-13, its major cleaving protease. (PubMed id 15238142)9 Mannucci P.M....Canciani M.T. (2004)
    825. Deletion of alanine 2201 in the FVIII C2 domain results in mild hemophilia A by impairing FVIII binding to VWF and phospholipids and destroys a major FVIII antigenic determinant involved in inhibitor development. (PubMed id 12969981)9 d'Oiron R....Jacquemin M. (2004)
    826. Thrombomodulin, von Willebrand factor and E-selectin as plasma markers of endothelial damage/dysfunction and activation in pregnancy induced hypertension. (PubMed id 15115667)9 Nadar S.K....Lip G.Y. (2004)
    827. Viral load and disease progression as responsible for endothelial activation and/or injury in human immunodeficiency virus-1-infected patients. (PubMed id 12544723)9 de LarraA+aga G.F....Benetucci J.A. (2003)
    828. Expression of human factor VIII under control of the platelet-specific alphaIIb promoter in megakaryocytic cell line as well as storage together with VWF. (PubMed id 12765843)9 Shi Q....Montgomery R.R. (2003)
    829. [Effect of tongxinluo capsule on function of vascular endothelium in patients with unstable angina pectoris] (PubMed id 14503056)9 Wang H.J....Sun J. (2003)
    830. Shear stress and von Willebrand factor in health and disease. (PubMed id 14631548)9 Tsai H.M. (2003)
    831. Surgery for gastric cancer increases plasma levels of vascular endothelial growth factor and von Willebrand factor. (PubMed id 12378339)9 Ikeda M....Satomi T. (2002)
    832. Blood coagulation and fibrinolysis in patients with hyperthyroidism. (PubMed id 12030606)9 Erem C....Telatar M. (2002)
    833. Persistent increase in plasma thrombomodulin in patients with a history of lupus nephritis: endothelial cell activation markers. (PubMed id 11296951)9 Frijns R....Derksen R. (2001)
    834. Plasma homocysteine, methylene tetrahydrofolate reductase C677T and factor II G20210A polymorphisms, factor VIII, and VWF in central retinal vein occlusion. (PubMed id 11673296)9 Boyd S....Hykin P.G. (2001)
    835. Endothelial perturbation in children and adolescents with type 1 diabetes: association with markers of the inflammatory reaction. (PubMed id 11522718)9 Romano M....DavA- G. (2001)
    836. Fibrinolytic actions of intra-arterial angiotensin II and bradykinin in vivo in man. (PubMed id 10974219)9 Labinjoh C....Webb D.J. (2000)
    837. Conformational changes in the D' domain of von Willebrand factor induced by CYS 25 and CYS 95 mutations lead to factor VIII binding defect and multimeric impairment. (PubMed id 10807780)9 Jorieux S....Mazurier C. (2000)
    838. Assembly of multimeric von Willebrand factor directs sorting of P-selectin. (PubMed id 10894814)9 Hop C....Pannekoek H. (2000)
    839. Enhanced shear-induced von Willebrand factor binding to platelets in acute myocardial infarction. (PubMed id 11113268)9 Li M....Handa S. (2000)
    840. Soluble cell adhesion molecules in patients with acute coronary syndrome. (PubMed id 11775266)9 Xie Y....Gong L. (2000)
    841. Mosaic-like distribution of endothelial cell antigens in capillaries and juxta-alveolar microvessels in the normal human lung. (PubMed id 10792772)9 Kawanami O....Takemura T. (2000)
    842. Effects of fixed low-dose warfarin, aspirin-warfarin combination therapy, and dose-adjusted warfarin on thrombogenesis in chronic atrial fibrillation. (PubMed id 10753983)9 Li-Saw-Hee F.L....Lip G.Y. (2000)
    843. Heterogeneous distribution of thrombomodulin and von Willebrand factor in endothelial cells in the human pulmonary microvessels. (PubMed id 10754601)9 Kawanami O....Ferrans V.J. (2000)
    844. Homocysteine concentration in primary and systemic sclerosis associated Raynaud's phenomenon. (PubMed id 11093443)9 Marasini B....Biondi M.L. (2000)
    845. A cross-sectional and diurnal study of thrombogenesis among patients with chronic atrial fibrillation. (PubMed id 10841245)9 Li-Saw-Hee F.L....Lip G.Y. (2000)
    846. Plasma VEGF and soluble VEGF receptor FLT-1 in proliferative retinopathy: relationship to endothelial dysfunction and laser treatment. (PubMed id 10892852)9 Lip P.L....Lip G.Y. (2000)
    847. Identification and characterization of endothelial glycoprotein Ib using viper venom proteins modulating cell adhesion. (PubMed id 10194440)9 Tan L....Niewiarowski S. (1999)
    848. Effect of von Willebrand Factor and its proteolytic fragments on kinetics of interaction between the light and heavy chains of human factor VIII. (PubMed id 10605949)9 Saenko E.L....Sarafanov A.G. (1999)
    849. Transcriptional expression of tissue factor pathway inhibitor, thrombomodulin and von Willebrand factor in normal human tissues. (PubMed id 10494762)9 Bajaj M.S....Bajaj S.P. (1999)
    850. Socioeconomic status and determinants of hemostatic function in healthy women. (PubMed id 10073947)9 Wamala S.P....Orth-GomAcr K. (1999)
    851. The light chain of factor VIII comprises a binding si te for low density lipoprotein receptor-related protein. (PubMed id 10446132)9 Lenting P.J....van Zonneveld A.J. (1999)
    852. Antifactor VIII antibody inhibiting allogeneic but not autologous factor VIII in patients with mild hemophilia A. (PubMed id 10090936)9 Peerlinck K....Vermylen J. (1999)
    853. Endothelial haemostatic factors are associated with progression of urinary albumin excretion in clinically healthy subjects: a 4-year prospective study. (PubMed id 10369792)9 Clausen P....Jensen J.S. (1999)
    854. Sex differences in coagulation and fibrinolysis in subjects with coronary artery disease. (PubMed id 9569183)9 Ossei-Gerning N....Grant P.J. (1998)
    855. The evaluation of factor VIII binding activity of von Willebrand factor by means of an ELISA method: significance and practical implications. (PubMed id 9495210)9 Casonato A....Girolami A. (1998)
    856. Diagnosis of von Willebrand disease type 2N: a simplified method for measurement of factor VIII binding to von Willebrand factor. (PubMed id 9692396)9 Miller C.H....Green D. (1998)
    857. Clinical management of patients with von Willebrand's disease with a VHP vWF concentrate: the French experience. (PubMed id 10028319)9 Goudemand J....Sultan Y. (1998)
    858. Evidence of a local mechanism for desmopressin-induced tissue-type plasminogen activator release in human forearm. (PubMed id 9427706)9 Wall U....Jern C. (1998)
    859. Requirement of prestimulated THP-1 monocytic cells for endothelial cell activation. Involvement of TNF alpha. (PubMed id 9105636)9 Roux M.E....Dosne A.M. (1997)
    860. Effects of hormone-replacement therapy on hemostatic factors, lipid factors, and endothelial function in women undergoing surgical menopause: implications for prevention of atherosclerosis. (PubMed id 9351746)9 Lip G.Y....Beevers D.G. (1997)
    861. Endothelial cell markers in bone marrow transplant recipients with and without acute graft-versus-host disease. (PubMed id 9156265)9 Salat C....Hiller E. (1997)
    862. Sympathoadrenal activation and muscarinic receptor stimulation induce acute release of tissue-type plasminogen activator but not von Willebrand factor across the human forearm. (PubMed id 9268190)9 Jern C....Jern S. (1997)
    863. Physiologic cleavage of von Willebrand factor by a plasma protease is dependent on its conformation and requires calcium ion. (PubMed id 8639782)9 Tsai H.M. (1996)
    864. Von Willebrand factor, thrombomodulin, thromboxane, beta-thromboglobulin and markers of fibrinolysis in primary Raynaud's phenomenon and systemic sclerosis. (PubMed id 8712862)9 Herrick A.L....Jayson M.I. (1996)
    865. Uremic patients have decreased shear-induced platelet aggregation mediated by decreased availability of glycoprotein IIb-IIIa receptors. (PubMed id 8604704)9 Sreedhara R....Hakim R.M. (1996)
    866. Factor VIII C2 domain missense mutations exhibit defective trafficking of biologically functional proteins. (PubMed id 8810344)9 Pipe S.W. and Kaufman R.J. (1996)
    867. Purification and characterization of bitiscetin, a no vel von Willebrand factor modulator protein from Bitis arietans snake venom. (PubMed id 8806626)9 Hamako J....Titani K. (1996)
    868. Factor VIII inhibitor antibodies with C2 domain specificity are less inhibitory to factor VIII complexed with von Willebrand factor. (PubMed id 8950785)9 Suzuki T....Fukutake K. (1996)
    869. Increased plasma levels of immunoreactive endothelin and von Willebrand factor in NIDDM patients. (PubMed id 7698054)9 Morise T....Takeda R. (1995)
    870. The role of von Willebrand factor in haemostasis and blood loss during and after cardiopulmonary bypass surgery. (PubMed id 8562836)9 Perrin E.J....Hawson G.A. (1995)
    871. [Subcutaneous administration of desmopressin to plasma donors: a controlled study] (PubMed id 8523926)9 Palacios S....Vicente V. (1995)
    872. Fibrinogen and markers of fibrinolysis and endothelial damage following resolution of critical limb ischaemia. (PubMed id 7552524)9 Woodburn K.R....Pollock J.G. (1995)
    873. Hemostatic abnormalities in patients with pulmonary embolism compared with that in deep vein thrombosis. (PubMed id 8562833)9 Yamada N....Suzuki K. (1995)
    874. Biological effect of desmopressin in eight patients with type 2N ('Normandy') von Willebrand disease. Collaborative Group. (PubMed id 7819109)9 Mazurier C....Goudemand M. (1994)
    875. [Coagulation and fibrinolytic parameters in patients with various angiopathies--analysis in cerebral thrombosis, diabetic and vasculitic neuropathies] (PubMed id 8403679)9 Kohriyama T....Nakamura S. (1993)
    876. Abnormalities of von Willebrand factor multimers in drug-associated thrombotic microangiopathies. (PubMed id 8438900)9 Charba D....Hester J.P. (1993)
    877. Transmembrane calcium influx associated with von Willebrand factor binding to GP Ib in the initiation of shear-induced platelet aggregation. (PubMed id 8391728)9 Ikeda Y....Itagaki I. (1993)
    878. Repeated infusions of DDAVP induce low response of FVIII and vWF but not of plasminogen activators. (PubMed id 8322282)9 Vicente V....Aznar J. (1993)
    879. Further evidence for recessive inheritance of von Willebrand disease with abnormal binding of von Willebrand factor to factor VIII. (PubMed id 1566742)9 Lopez-Fernandez M.F....Batlle J. (1992)
    880. Aurin tricarboxylic acid inhibits platelet adhesion to collagen by binding to the 509-695 disulphide loop of von Willebrand factor and competing with glycoprotein Ib. (PubMed id 1287886)9 Girma J.P....Meyer D. (1992)
    881. Monocytes enhance endothelial von Willebrand factor r elease and prostacyclin production with different kinetics and dependency on in tercellular contact between these two cell types. (PubMed id 1581234)9 Hakkert B.C....van Mourik J.A. (1992)
    882. Impaired release of tissue plasminogen activator (t-PA) following DDAVP infusion in von Willebrand's disease with low platelet von Willebrand factor content. (PubMed id 1606286)9 Casonato A....Girolami A. (1992)
    883. Aprotinin does not inhibit the release of PGI2 or vWF from cultured human endothelial cells. (PubMed id 1377415)9 Royston B.D....Pearson J.D. (1992)
    884. Fibrinolytic system during long-distance running in IDDM patients and in healthy subjects. (PubMed id 1505332)9 van Loon B.J....Meinders A.E. (1992)
    885. The mutation Arg (53)----Trp causes von Willebrand disease Normandy by abolishing binding to factor VIII. Studies with recombinant von Willebrand factor. (PubMed id 1732004)9 Jorieux S....Sadler J.E. (1992)
    886. Qualitative assessment of von Willebrand factor (vWF) in cirrhotics following repeated doses of desmopressin acetate. (PubMed id 1909903)9 Cardin F....Burroughs A.K. (1991)
    887. Abnormal binding of factor VIII is linked with the substitution of glutamine for arginine 91 in von Willebrand factor in a variant form of von Willebrand disease. (PubMed id 1918030)9 Kroner P.A....Montgomery R.R. (1991)
    888. Ristocetin and botrocetin involve two distinct domains of von Willebrand factor for binding to platelet membrane glycoprotein Ib. (PubMed id 1702906)9 Girma J.P....Meyer D. (1990)
    889. Studies on the pathogenesis of coagulopathy in patients with arterial thromboembolism and malignancy. (PubMed id 2148228)9 Uchiyama T....Kobayashi N. (1990)
    890. Secondhand smoke (SHS) exposure is associated with ci rculating markers of inflammation and endothelial function in adult men and wom en. (PubMed id 19700161)9 Jefferis B.J....Whincup P.H. (2010)
    891. Von Willebrand factor, ADAMTS-13, and thrombotic thro mbocytopenic purpura. (PubMed id 20391298)9 Zhou Z....Dong J.F. (2010)
    892. 25-Hydroxyvitamin D and pre-clinical alterations in i nflammatory and hemostatic markers: a cross sectional analysis in the 1958 Brit ish Birth Cohort. (PubMed id 20520739)9 HyppAPnen E....Power C. (2010)
    893. [Homocysteine and von Willebrand factor in chronic al coholism] (PubMed id 20524338)9 Koriakin A.M....GorbatovskiA- I.a.A. (2010)
    894. Coagulation factors as biological risk markers of end othelial dysfunction. Association with the thrombotic episodes of chronic hemod ialysis patients. (PubMed id 20011089)9 Sioulis A....Grekas D. (2009)
    895. Managing patients with von Willebrand disease type 1, 2 and 3 with desmopressin and von Willebrand factor-factor VIII concentrate in surgical settings. (PubMed id 19506363)9 Michiels J.J....Gadisseur A. (2009)
    896. von Willebrand factor is a major determinant of ADAMTS-13 decrease during mouse sepsis induced by cecum ligation and puncture. (PubMed id 19187073)9 Lerolle N....Baruch D. (2009)
    897. Effect of ginkgo leaf extract on vascular endothelial function in patients with early stage diabetic nephropathy. (PubMed id 19271166)9 Li X.S....Ye S.H. (2009)
    898. [Clinical effect and mechanismn of xuefu zhuyu capsule in treating unstable angina pectoris] (PubMed id 19338157)9 Zheng G.L. and Wang S.H. (2009)
    899. von Willebrand factor-cleaving protease ADAMTS13 redu ces ischemic brain injury in experimental stroke. (PubMed id 19687510)9 Zhao B.Q....Wagner D.D. (2009)
    900. Effects of losartan on fibrinolytic parameters and vo n Willebrand factor in Chinese subjects with hypertension: a comparative study versus atenolol. (PubMed id 19589241)9 Liu J....Huang J.H. (2009)
    901. Oxidative stress but not endothelial dysfunction exists in non-obese, young group of patients with polycystic ovary syndrome. (PubMed id 19308750)9 KuA9Asu N.K. and Var A. (2009)
    902. Proliferative diabetic retinopathy-The influence of diabetes control on the activation of the intraocular molecule system. (PubMed id 19237221)9 Adamiec-Mroczek J....Misiuk-HojA8o M. (2009)
    903. [Development of a monoclonal antibody to factor VIII C2 domain and its functional study] (PubMed id 19642361)9 Li Z.Y....Ruan C.G. (2009)
    904. In vitro plasma-induced endothelial oxidative stress and circulating markers of endothelial dysfunction in preeclampsia: an observational study. (PubMed id 19437231)9 Pottecher J....Tsatsaris V. (2009)
    905. Early initiation of low-dose atorvastatin treatment after an acute ST-elevated myocardial infarction, decreases inflammatory process and prevents endothelial injury and activation. (PubMed id 18187214)9 Stefanadi E....Stefanadis C. (2009)
    906. ADAMTS-13 attenuates thrombus formation on type I collagen surface and disrupted plaques under flow conditions. (PubMed id 18801485)9 Moriguchi-Goto S....Asada Y. (2009)
    907. Levothyroxine (LT4) suppression treatment for benign thyroid nodules alters coagulation. (PubMed id 19138314)9 Demir T....Yesil S. (2009)
    908. Decreased ADAMTS13 levels in patients after living do nor liver transplantation. (PubMed id 19423151)9 Kobayashi T....Isaji S. (2009)
    909. Increased thrombin-activatable fibrinolysis inhibitor and decreased tissue factor pathway inhibitor in patients with hypothyroidism. (PubMed id 18958631)9 Erem C....Ersoz H.O. (2009)
    910. Influence of atrial fibrillation on plasma von willebrand factor, soluble E-selectin, and N-terminal pro B-type natriuretic peptide levels in systolic heart failure. (PubMed id 18339785)9 Freestone B....Lip G.Y. (2008)
    911. Reduced number and activity of circulating endothelial progenitor cells in patients with idiopathic pulmonary arterial hypertension. (PubMed id 18394873)9 Junhui Z....Junzhu C. (2008)
    912. Flow induces loop-to-beta-hairpin transition on the beta-switch of platelet glycoprotein Ib alpha. (PubMed id 18772372)9 Lou J. and Zhu C. (2008)
    913. Biologic response to subcutaneous and intranasal ther apy with desmopressin in a large Amish kindred with Type 2M von Willebrand dise ase. (PubMed id 18312368)9 Sharthkumar A....Shapiro A. (2008)
    914. Association between thrombotic microangiopathy and reduced ADAMTS13 activity in malignant hypertension. (PubMed id 18332284)9 van den Born B.J....van Montfrans G.A. (2008)
    915. Evidence-based diagnosis of type 1 von Willebrand disease: a Bayes theorem approach. (PubMed id 18187661)9 Tosetto A....Rodeghiero F. (2008)
    916. A phase II prospective open-label escalating dose trial of recombinant interleukin-11 in mild von Willebrand disease. (PubMed id 18680527)9 Ragni M.V....Nichols T.C. (2008)
    917. Changes in plasma von Willebrand factor-cleaving protease (ADAMTS13) levels in patients with unstable angina. (PubMed id 18295305)9 Fuchigami S....Ogawa H. (2008)
    918. [Effects of puerarin with aspirin on the markers of damaged vascular endothelial cells in patients with acute cerebral infarction] (PubMed id 19260323)9 Hu H.T....Ding M.P. (2008)
    919. PFA-100 monitoring of von Willebrand factor (VWF) responses to desmopressin (DDAVP) and factor VIII/VWF concentrate substitution in von Willebrand disease type 1 and 2. (PubMed id 18766263)9 van Vliet H.H....Michiels J.J. (2008)
    920. ADAMTS13 cleavage efficiency is altered by mutagenic and, to a lesser extent, polymorphic sequence changes in the A1 and A2 domains of von Willebrand factor. (PubMed id 18986390)9 Pruss C.M....Lillicrap D. (2008)
    921. Interaction of the cysteine-rich domain of snake venom metalloproteinases with the A1 domain of von Willebrand factor promotes site-specific proteolysis of von Willebrand factor and inhibition of von Willebrand factor-mediated platelet aggregation. (PubMed id 17578514)9 Serrano S.M....Fox J.W. (2007)
    922. An IAP retrotransposon in the mouse ADAMTS13 gene creates ADAMTS13 variant proteins that are less effective in cleaving von Willebrand factor multimers. (PubMed id 17426255)9 Zhou W....Tsai H.M. (2007)
    923. Coagulation, fibrinolytic system activation and endothelial dysfunction in patients with mitral stenosis and sinus rhythm. (PubMed id 17351162)9 Topaloglu S....Korkmaz S. (2007)
    924. Differences in inflammatory and thrombotic markers between unstable angina and acute myocardial infarction. (PubMed id 16787670)9 Tousoulis D....Stefanadis C. (2007)
    925. Mapping von Willebrand factor A domain binding sites on a snake venom metalloproteinase cysteine-rich domain. (PubMed id 17118332)9 Pinto A.F....Fox J.W. (2007)
    926. Serial changes in von Willebrand factor-cleaving protease (ADAMTS13) and prognosis after acute myocardial infarction. (PubMed id 17719316)9 Matsukawa M....Ogawa H. (2007)
    927. Time course of platelet activation and von Willebrand factor in patients with non-valvular atrial fibrillation after ischemic stroke. (PubMed id 17322628)9 Yip H.K....Liou C.W. (2007)
    928. The effects of direct current cardioversion for persistent atrial fibrillation on indices of endothelial damage/dysfunction. (PubMed id 16318868)9 Freestone B....Lip G.Y. (2006)
    929. Analysis on the molecular species and concentration of circulating ADAMTS13 in Blood. (PubMed id 16428330)9 Soejima K....Nakagaki T. (2006)
    930. Endothelial activation, dysfunction, and damage in congestive heart failure and the relation to brain natriuretic peptide and outcomes. (PubMed id 16490435)9 Chong A.Y....Lip G.Y. (2006)
    931. Impaired flow-mediated vasodilation, carotid artery intima-media thickening, and elevated endothelial plasma markers in obese children: the impact of cardiovascular risk factors. (PubMed id 16651309)9 Meyer A.A....Kienast W. (2006)
    932. Endothelial dysfunction and systemic inflammation in persons with echolucent carotid plaques. (PubMed id 16807651)9 With NotA...Hansen J.B. (2006)
    933. The role of ADAMT-13 in platelet adhesion in flow: methods for diagnosis of thrombotic thrombocytopenic purpura. (PubMed id 16855353)9 Shenkman B. (2006)
    934. Validity of plasma fibrinogen, D-dimer, and the von Willebrand factor as markers of cardiovascular morbidity in patients on chronic hemodialysis. (PubMed id 16449948)9 Kirmizis D....Barboutis K. (2006)
    935. The 80th anniversary of von Willebrand's disease: history, management and research. (PubMed id 17083505)9 Federici A.B....Lee C.A. (2006)
    936. Genetic influences on fibrinogen, tissue plasminogen activator-antigen and von Willebrand factor in males and females. (PubMed id 16525567)9 de Lange M....Snieder H. (2006)
    937. The association between fibrinogen, von Willebrand Factor, antithrombin III, and D-dimer levels and survival outcome by 36 months from ovarian cancer. (PubMed id 16444428)9 Koh S.C....Choolani M. (2006)
    938. Plasma haemostatic markers, endothelial function and ambulatory blood pressure changes with home versus hospital cardiac rehabilitation: the Birmingham Rehabilitation Uptake Maximisation Study. (PubMed id 16807272)9 Lee K.W....Lip G.Y. (2006)
    939. Interplay between ADAMTS13 and von Willebrand factor in inherited and acquired thrombotic microangiopathies. (PubMed id 15662617)9 Soejima K. and Nakagaki T. (2005)
    940. Inflammatory response and re-stenosis after percutaneous coronary intervention in heart transplant recipients and patients with native atherosclerosis. (PubMed id 16102437)9 Hognestad A....Andreassen A.K. (2005)
    941. Impaired tissue Doppler diastolic function in patients with coronary artery disease: relationship to endothelial damage/dysfunction and platelet activation. (PubMed id 16209979)9 Lee K.W....Lip G.Y. (2005)
    942. Characterization of a myeloma patient with a life-threatening hemorrhagic diathesis: presence of a lambda dimer protein inhibiting shear-induced platelet aggregation by binding to the A1 domain of von Willebrand factor. (PubMed id 15886805)9 Shinagawa A....Nagasawa T. (2005)
    943. Incremental shuttle walking is associated with activation of haemostatic and haemorheological markers in patients with coronary artery disease: the Birmingham rehabilitation uptake maximization study (BRUM). (PubMed id 15774609)9 Lee K.W....Lip G.Y. (2005)
    944. Cleavage of von Willebrand factor by ADAMTS-13 in vitro: effect of temperature and barium ions on the proteolysis kinetics. (PubMed id 16269936)9 Perutelli P....Molinari A.C. (2005)
    945. [Von Willebrand disease: from diagnosis to treatment] (PubMed id 16519045)9 Fressinaud E. and Meyer D. (2005)
    946. Impact of surgery and chemotherapy on von Willebrand factor and vascular endothelial growth factor levels in colorectal cancer. (PubMed id 15960922)9 Gil-Bazo I....GarcA-a-Foncillas LA^pez J. (2005)
    947. Lack of desmopressin (DDAVP) response in men with hemophilia A following liver transplantation. (PubMed id 16194203)9 Lamont P.A. and Ragni M.V. (2005)
    948. Effects of exercise training and deconditioning on platelet aggregation induced by alternating shear stress in men. (PubMed id 15569820)9 Wang J.S....Chen Y.W. (2005)
    949. Plasma levels of tissue factor and soluble E-selectin in sickle cell disease: relationship to genotype and to inflammation. (PubMed id 15795541)9 Mohan J.S....Blann A.D. (2005)
    950. [Study on changes of blood coagulation factors in rats with hemorrhagic shock] (PubMed id 15748447)9 Zhang Y.J....Wang M.S. (2005)
    951. Insulin resistance and endothelial dysfunction in type 2 diabetes patients with or without microalbuminuria. (PubMed id 15223221)9 Yu Y....Tang H. (2004)
    952. Endothelial nitric oxide synthase expression in neuro genic urinary bladders treated with intravesical resiniferatoxin. (PubMed id 14764132)9 Apostolidis A.N....Anand P. (2004)
    953. Intense exercise increases shear-induced platelet aggregation in men through enhancement of von Willbrand factor binding, glycoprotein IIb/IIIa activation, and P-selectin expression on platelets. (PubMed id 14872251)9 Wang J.S. (2004)
    954. [Von Willebrand factor and thrombomodulin as markers of endothelial cell functions in children with chronic viral hepatitis] (PubMed id 15557702)9 Kulwas A....Kotschy M. (2004)
    955. Severity of venous insufficiency is related to the density of microvascular deposition of PAI-1, uPA and von Willebrand factor. (PubMed id 15061043)9 Kolbach D.N....Cleutjens J.P. (2004)
    956. Can von Willebrand factor, platelet-endothelial cell adhesion molecule-1 and thrombomodulin be used as alternative markers of endothelial cell injury in human glomerulonephritis? (PubMed id 15631346)9 Niemir Z.I....Czekalski S. (2004)
    957. Haemostatic and inflammatory biomarkers in advanced chronic heart failure: role of oral anticoagulants and successful heart transplantation. (PubMed id 15198737)9 Cugno M....Gregorini L. (2004)
    958. Endothelial dysfunction and damage in congestive heart failure: relation of flow-mediated dilation to circulating endothelial cells, plasma indexes of endothelial damage, and brain natriuretic peptide. (PubMed id 15364797)9 Chong A.Y....Lip G.Y. (2004)
    959. Oxidised and native low-density lipoproteins induce the release of von Willebrand factor from human endothelial cells in vitro. (PubMed id 14560792)9 Blann A.D....McCollum C.N. (2003)
    960. Acute release of plasminogen activator inhibitor-1 in ST-segment elevation myocardial infarction predicts mortality. (PubMed id 12860898)9 Collet J.P....Thomas D. (2003)
    961. Von Willebrand disease type 1: a diagnosis in search of a disease. (PubMed id 12411289)9 Sadler J.E. (2003)
    962. Vitamin C affects thrombosis/ fibrinolysis system and reactive hyperemia in patients with type 2 diabetes and coronary artery disease. (PubMed id 14514574)9 Tousoulis D....Stefanadis C. (2003)
    963. Endothelial markers and HIV infection in the era of highly active antiretroviral treatment. (PubMed id 12893023)9 de Larranaga G.F....Benetucci J.A. (2003)
    964. [Thrombomodulin, von Willebrand factor and tissue plasminogen activator in the blood plasma of obese women and men] (PubMed id 15058251)9 RoA9A8 D....Michalski A. (2003)
    965. Plasmatic nitric oxide, but not von Willebrand Factor, is an early marker of endothelial damage, in type 1 diabetes mellitus patients without microvascular complications. (PubMed id 12954155)9 Correa R.C. and Alfieri A.B. (2003)
    966. Neither carvedilol nor bisoprolol in maximally tolerated doses has any specific advantage in lowering chronic heart failure oxidant stress: implications for beta-blocker selection. (PubMed id 12841846)9 Chin B.S....Lip G.Y. (2003)
    967. Markers of endothelial function in pediatric stem cell transplantation for acute leukemia. (PubMed id 12426679)9 Luzzatto G....Zanesco L. (2003)
    968. Prognostic value of plasma von Willebrand factor and soluble P-selectin as indices of endothelial damage and platelet activation in 994 patients with nonvalvular atrial fibrillation. (PubMed id 12796127)9 Conway D.S....Lip G.Y. (2003)
    969. [Effect of tetramethylpyrazine on endothelin, von Willebrand factor and thromboxane A2 during cardiopulmonary bypass in patients of congenital heart disease with pulmonary hypertension] (PubMed id 12764908)9 Huang R.J....Chen D.Z. (2003)
    970. von Willebrand factor and its propeptide in children with diabetes. Relation between endothelial dysfunction and microalbuminuria. (PubMed id 12595584)9 Verrotti A....Chiarelli F. (2003)
    971. Angiogenesis, thrombogenesis, endothelial dysfunction and angiographic severity of coronary artery disease. (PubMed id 14617549)9 Chung N.A....Lip G.Y. (2003)
    972. Platelets' glycoproteins and their ligands in patients with intermittent claudication. (PubMed id 12865882)9 Gosk-Bierska I....Szuba A. (2003)
    973. Effects of dexamethasone on clinical course, C-reacti ve protein, S100B protein and von Willebrand factor antigen after paediatric ca rdiac surgery. (PubMed id 12765886)9 Lindberg L....Olsson A.K. (2003)
    974. Overexpression of von Willebrand factor is an independent risk factor for pathogenesis of intimal hyperplasia: preliminary studies. (PubMed id 12563218)9 Qin F....Dardik H. (2003)
    975. Proline-rich tyrosine kinase 2 and focal adhesion kinase are involved in different phases of platelet activation by vWF. (PubMed id 11916084)9 Canobbio I....Torti M. (2002)
    976. Angiotensin-converting enzyme activity is involved in the mechanism of increased endogenous nitric oxide synthase inhibitor in patients with type 2 diabetes mellitus. (PubMed id 12224817)9 Ito A....Takeshita A. (2002)
    977. Uremic medium causes expression, redistribution and shedding of adhesion molecules in cultured endothelial cells. (PubMed id 12368160)9 Serradell M....Escolar G. (2002)
    978. Comparative short-term prognostic value of hemostatic and inflammatory markers in patients with non-ST elevation acute coronary syndromes. (PubMed id 11899586)9 Passoni F....De Servi S. (2002)
    979. Distinct glycoprotein Ib/V/IX and integrin alpha IIbbeta 3-dependent calcium signals cooperatively regulate platelet adhesion under flow. (PubMed id 11713259)9 Nesbitt W.S....Jackson S.P. (2002)
    980. Expression of the endothelial markers PECAM-1, vWf, and CD34 in vivo and in vitro. (PubMed id 12009786)9 Muller A.M....Kirkpatrick C.J. (2002)
    981. Angiogenesis in pterygium: morphometric and immunohis tochemical study. (PubMed id 12518239)9 Marcovich A.L....Bar-Dayan Y. (2002)
    982. Treatment of Raynaud's phenomenon with intravenous prostaglandin E1alpha-cyclodextrin improves endothelial cell injury in systemic sclerosis. (PubMed id 11327251)9 Gardinali M....Stabilini R. (2001)
    983. Poly(ethylenimine)-mediated gene delivery affects endothelial cell function and viability. (PubMed id 11214758)9 Godbey W.T....Mikos A.G. (2001)
    984. Differential effects of radiocontrast agents on human umbilical vein endothelial cells: cytotoxicity and modulators of thrombogenicity. (PubMed id 11726305)9 Fauser C....Haller C. (2001)
    985. Abnormalities of hemorheological, endothelial, and platelet function in patients with chronic heart failure in sinus rhythm: effects of angiotensin-converting enzyme inhibitor and beta-blocker therapy. (PubMed id 11282905)9 Gibbs C.R....Lip G.Y. (2001)
    986. Increased soluble P-selectin in patients with haematological and breast cancer: a comparison with fibrinogen, plasminogen activator inhibitor and von Willebrand factor. (PubMed id 11229826)9 Blann A.D....Lip G.Y. (2001)
    987. Effect of acute exercise on the raised plasma fibrinogen, soluble P-selectin and von Willebrand factor levels in chronic atrial fibrillation. (PubMed id 11346250)9 Li-Saw-Hee F.L....Lip G.Y. (2001)
    988. Co-adsorbed fibrinogen and von Willebrand factor augment platelet procoagulant activity and spreading. (PubMed id 11334184)9 Grunkemeier J.M....Horbett T.A. (2001)
    989. Endothelial dysfunction, nitric oxide and platelet activation in hypertensive and diabetic type II patients. (PubMed id 11323020)9 OuviA+a S.M....Sassetti B. (2001)
    990. Effects of fixed low-dose warfarin on hemostatic factors in continuous ambulatory peritoneal dialysis patients. (PubMed id 11157376)9 Kim S.B....Yang W.S. (2001)
    991. Haemostasis in ischaemic stroke and vascular dementia. (PubMed id 11734665)9 Stott D.J....Lowe G.D. (2001)
    992. Endothelial perturbation in cystic fibrosis. (PubMed id 11776300)9 Romano M....DavA- G. (2001)
    993. Sequential changes in von Willebrand factor and soluble thrombomodulin in acute ischemic stroke. (PubMed id 17903836)9 Nomura E....Nakamura S. (2001)
    994. Adherence properties of Staphylococcus aureus under static and flow conditions: roles of agr and sar loci, platelets, and plasma ligands. (PubMed id 11401988)9 Shenkman B....Varon D. (2001)
    995. Type 1 von Willebrand disease - a clinical retrospective study of the diagnosis, the influence of the ABO blood group and the role of the bleeding history. (PubMed id 10691852)9 Nitu-Whalley I.C....Pasi K.J. (2000)
    996. Von Willebrand's factor mediates the adherence of hum an tumoral cells to human endothelial cells and ticlopidine interferes with thi s effect. (PubMed id 11100896)9 Morganti M....Mittermayer C. (2000)
    997. Serum soluble vascular cell adhesion molecule-1: role as a surrogate marker of angiogenesis. (PubMed id 10944555)9 Byrne G.J....Bundred N.J. (2000)
    998. Mutation in the leucine-rich repeat of platelet glycoprotein Ib alpha results in defects in its interaction with immobilized von Willebrand factor under flow. (PubMed id 11776050)9 Dong J....Lopez J.A. (2000)
    999. Increased platelet activation and endothelial dysfunction in patients with atrial fibrillation immediately following percutaneous balloon mitral valvuloplasty. (PubMed id 10941544)9 Goldsmith I.R....Lip G.Y. (2000)
    1000. von Willebrand factor binding to heparin in various t ypes of von Willebrand disease. (PubMed id 11920189)9 Rastegar-Lari G....Baruch D. (2000)
    1001. A new approach to antiplatelet therapy: inhibitor of GPIb/V/IX-vWF interaction. (PubMed id 11182627)9 Ikeda Y....Goto S. (2000)
    1002. von Willebrand factor, fibrinogen, and soluble P-selectin levels after mitral valve replacement versus mitral valve repair. (PubMed id 10802004)9 Goldsmith I.R....Lip G.Y. (2000)
    1003. Vascular endothelial growth factor expression and neovascularisation in non-small cell lung cancer. (PubMed id 10738124)9 Yano T....Horie T. (2000)
    1004. Desmopressin: therapeutic limitations in children and adults with inherited coagulation disorders. (PubMed id 10929043)9 Nolan B....Smith O.P. (2000)
    1005. The effect of adsorbed fibrinogen, fibronectin, von Willebrand factor and vitronectin on the procoagulant state of adherent platelets. (PubMed id 11026630)9 Grunkemeier J.M....Horbett T.A. (2000)
    1006. Plasma fibrinogen, haemostatic factors and prediction of peripheral arterial disease in the Edinburgh Artery Study. (PubMed id 10691098)9 Smith F.B....Fowkes F.G. (2000)
    1007. Local and systemic effects of intra-arterial desmopressin in healthy volunteers and patients with type 3 von Willebrand disease. Role of interleukin-6. (PubMed id 10959689)9 Newby D.E....Ludlam C.A. (2000)
    1008. Analysis of the roles of 14-3-3 in the platelet glycoprotein Ib-IX-mediated activation of integrin alpha(IIb)beta(3) using a reconstituted mammalian cell expression model. (PubMed id 10579727)9 Gu M....Du X. (1999)
    1009. Correlation between von Willebrand factor levels and early graft function in clinical liver transplantation. (PubMed id 10081631)9 Basile J....Miller C.M. (1999)
    1010. Plasma levels of the three endothelial-specific proteins von Willebrand factor, tissue factor pathway inhibitor, and thrombomodulin do not predict the development of acute respiratory distress syndrome. (PubMed id 10654210)9 Bajaj M.S. and Tricomi S.M. (1999)
    1011. Serotonin-induced secretion of von Willebrand factor from human umbilical vein endothelial cells via the cyclic AMP-signaling systems independent of increased cytoplasmic calcium concentration. (PubMed id 11230807)9 SchlA1ter T. and Bohnensack R. (1999)
    1012. Real-time analysis of mural thrombus formation in various platelet aggregation disorders: distinct shear-dependent roles of platelet receptors and adhesive proteins under flow. (PubMed id 10419888)9 Tsuji S....Yoshioka A. (1999)
    1013. Platelet von Willebrand factor in Hermansky-Pudlak syndrome. (PubMed id 9766795)9 McKeown L.P....Rick M.E. (1998)
    1014. Effects of human recombinant, plasma-derived and porcine von Willebrand factor in pigs with severe von Willebrand disease. (PubMed id 9690808)9 Roussi J....Drouet L. (1998)
    1015. Impaired release of tissue plasminogen activator from the endothelium in Graves' disease - indicator of endothelial dysfunction and reduced fibrinolytic capacity. (PubMed id 9893018)9 Li Y....Sun X. (1998)
    1016. In-vitro effect of oncostatin M on the release by endothelial cells of von Willebrand factor, tissue-type plasminogen activator and plasminogen activator inhibitor-1. (PubMed id 9863709)9 Pourtau J....Vasse M. (1998)
    1017. Ser752 mutation to Pro or Ala in the beta3 integrin subunit differentially affects the kinetics of cell spreading to von Willebrand factor and fibrinogen. (PubMed id 9865467)9 Perrault C....Baruch D. (1998)
    1018. Circulating von Willebrand factor antigen II in atherosclerosis: a comparison with von Willebrand factor and soluble thrombomodulin. (PubMed id 9663709)9 Blann A.D....McCollum C.N. (1998)
    1019. Type 2M von Willebrand disease: F606I and I662F mutations in the glycoprotein Ib binding domain selectively impair ristocetin- but not botrocetin-mediated binding of von Willebrand factor to platelets. (PubMed id 9473222)9 Hillery C.A....Montgomery R.R. (1998)
    1020. A novel mutation in the D3 domain of von Willebrand factor markedly decreases its ability to bind factor VIII and affects its multimerization. (PubMed id 9845532)9 Jorieux S....Mazurier C. (1998)
    1021. Hemoperfusion with polymyxin B-immobilized fiber attenuates the increased plasma levels of thrombomodulin and von Willebrand factor from patients with septic shock. (PubMed id 9736787)9 Nakamura T....Koide H. (1998)
    1022. Effects of histamine and nitric oxide synthase inhibition on plasma levels of von Willebrand factor antigen. (PubMed id 9488498)9 Jilma B....Kapiotis S. (1998)
    1023. High plasminogen activator inhibitor and tissue plasminogen activator levels in plasma precede a first acute myocardial infarction in both men and women: evidence for the fibrinolytic system as an independent primary risk factor. (PubMed id 9826309)9 ThAPgersen A.M....Hallmans G. (1998)
    1024. A study of desmopressin and blood loss during spinal fusion for neuromuscular scoliosis: a randomized, controlled, double-blinded st udy. (PubMed id 9286889)9 Theroux M.C....Kettrick R.G. (1997)
    1025. An endothelial storage granule for tissue-type plasminogen activator. (PubMed id 9314543)9 Emeis J.J....Lupu F. (1997)
    1026. Respective evaluation of the prevalence of haemostasis abnormalities in unexplained primary early recurrent miscarriages. The Nimes Obstetricians and Haematologists (NOHA) Study. (PubMed id 9241739)9 Gris J.C....MarA"s P. (1997)
    1027. Percutaneous interventions alter the hemostatic profile of patients with unstable versus stable angina. (PubMed id 9350928)9 Yazdani S....Rabbani L.E. (1997)
    1028. von Willebrand factor and factor VIII: C in acute cerebrovascular disease. Relationship to stroke subtype and mortality. (PubMed id 9241740)9 Catto A.J....Grant P.J. (1997)
    1029. Distribution of adhesion molecules on HeLa cells, platelets and endothelium in an in vitro model mimicking the early phase of metastasis. An immunogold electron microscopic study. (PubMed id 9269301)9 Klementsen B....rgensen L. (1997)
    1030. Decreased half-life time of plasma von Willebrand factor collagen binding activity in essential thrombocythaemia: normalization after cytoreduction of the increased platelet count. (PubMed id 9432029)9 van Genderen P.J....Michiels J.J. (1997)
    1031. Coexistence of anti-phospholipid antibodies and endothelial perturbation in systemic lupus erythematosus patients with ongoing prothrombotic state. (PubMed id 9118509)9 Ferro D....Violi F. (1997)
    1032. Hemostasis in patients with severe von Willebrand disease improves after normal platelet transfusion and normalizes with further correction of the plasma defect. (PubMed id 9280321)9 Castillo R....Ordinas A. (1997)
    1033. Relative importance of the glycoprotein Ib-binding domain and the RGD sequence of von Willebrand factor for its interaction with endothelial cells. (PubMed id 9310484)9 Perrault C....Baruch D. (1997)
    1034. Lower androgenicity is associated with higher plasma levels of prothrombotic factors irrespective of age, obesity, body fat distribution, and related metabolic parameters in men. (PubMed id 9361687)9 De Pergola G....Giorgino R. (1997)
    1035. Vascular endothelial lesion in patients undergoing bone marrow transplantation. (PubMed id 8932851)9 Richard S....Boisseau M. (1996)
    1036. Proteolysis of von Willebrand factor is decreased in acute promyelocytic leukaemia by treatment with all-trans-retinoic acid. (PubMed id 8616045)9 Federici A.B....Mannucci P.M. (1996)
    1037. Plasma von Willebrand Factor Antigen (vWF:AG) and thrombomodulin (TM) levels in Adult Thrombotic Thrombocytopenic Purpura/Hemolytic Uremic Syndromes (TTP/HUS) and bone marrow transplant-associated thrombotic microangiopathy (BMT-TM). (PubMed id 8948657)9 Zeigler Z.R....George J.N. (1996)
    1038. Effect of deamino-8-D-arginine desmopressin in uremic bleeding. (PubMed id 8854651)9 Hong S.Y. and Yang D.H. (1996)
    1039. Factor VII hyperactivity and endothelial cell damage are found in elderly hypertensives only when concomitant with microalbuminuria. (PubMed id 8630673)9 Kario K....Shimada K. (1996)
    1040. Raised serum sialic acid concentration precedes onset of microalbuminuria in IDDM. A 10-year follow-up study. (PubMed id 8732705)9 Yokoyama H....Deckert T. (1996)
    1041. The defective interaction between von Willebrand factor and factor VIII in a patient with type 1 von Willebrand disease is caused by substitution of Arg19 and His54 in mature von Willebrand factor. (PubMed id 8562925)9 Kroner P.A....Montgomery R.R. (1996)
    1042. Expression of tissue-type plasminogen activator, plasminogen activator inhibitor and von Willebrand factor in the supernatant of endothelial cell cultures in response to the seeding of adenocarcinoma cell line HRT-18. (PubMed id 8952858)9 Morganti M....Sagripanti A. (1996)
    1043. von Willebrand factor, a possible indicator of endothelial cell damage, decreases during long-term compliance with a lipid-lowering diet. (PubMed id 7782727)9 Blann A.D....Watts G.F. (1995)
    1044. Hyperhomocysteinaemia and endothelial dysfunction in young patients with peripheral arterial occlusive disease. (PubMed id 7781664)9 Van den Berg M....Stehouwert C.D. (1995)
    1045. Reactive oxygen intermediates induce regulated secretion of von Willebrand factor from cultured human vascular endothelial cells. (PubMed id 7756649)9 Vischer U.M....Theler J.M. (1995)
    1046. Increased markers of thrombogenesis in chronic atrial fibrillation: effects of warfarin treatment. (PubMed id 7626351)9 Lip G.Y....Dunn F.G. (1995)
    1047. Different organization of von Willebrand factor oligomers in type-2A and -2B von Willebrand disease variants: effects of DDAVP infusion and protease inhibitors. (PubMed id 7578526)9 Casonato A....Girolami A. (1995)
    1048. Effect of nifedipine on changes in fibrinogen and von Willebrand factor in haemodialysis patients treated with recombinant human erythropoietin. (PubMed id 7605873)9 Taylor J.E....Stewart W.K. (1995)
    1049. Endothelial haemostatic factors may be associated with mortality in patients on long-term anticoagulant treatment. (PubMed id 8584993)9 BrAonnstrAPm M....Nilsson T.K. (1995)
    1050. Von Willebrand factor antigen in assessment of vasculitis in patients with connective tissue diseases. (PubMed id 8187441)9 Kloczko J....Radziwon P. (1994)
    1051. Absence of ligands bound to glycoprotein IIB-IIIA on the exposed surface of a thrombus may limit thrombus growth in flowing blood. (PubMed id 8083351)9 Heynen H.F....Sixma J.J. (1994)
    1052. Multiple platelet surface receptors mediate platelet adhesion to surfaces coated with plasma proteins. (PubMed id 8041127)9 DiFazio L.T....Haimovich B. (1994)
    1053. Monoclonal antibodies to platelet glycoproteins Ib and IIb/IIIa inhibit adhesion of platelets to purified solid-phase von Willebrand factor. (PubMed id 8051492)9 Danton M.C....Olson J.D. (1994)
    1054. Secretory response of the vessel wall to DDAVP and venous occlusion in von Willebrand's disease. (PubMed id 7992599)9 Bykowska K....Lopaciuk S. (1994)
    1055. Immunohistochemical staining of von Willebrand factor in endometrium of women during the first year of Norplant implants use. (PubMed id 7859456)9 Au C.L....Rogers P.A. (1994)
    1056. Purification of factor VIII/von Willebrand factor from human plasma on immobilized lentil lectin. (PubMed id 8054845)9 Zhou F.L....Burnouf T. (1994)
    1057. Expression of adhesion molecules in endothelial cells during allogeneic bone marrow transplantation. (PubMed id 7517372)9 Shen N....Dechavanne M. (1994)
    1058. Biological effects of a S/D-treated, very high purity, von Willebrand factor concentrate in five patients with severe von Willebrand disease. (PubMed id 8148475)9 Meriane F....Mazurier C. (1993)
    1059. Demonstration of Rickettsia conorii-induced endothelial injury in vivo by measuring circulating endothelial cells, thrombomodulin, and von Willebrand factor in patients with Mediterranean spotted fever. (PubMed id 7691249)9 George F....Sampol J. (1993)
    1060. Expression of platelet alpha-granule proteins in a human megakaryocytic leukemia cell line (CMK 11-5). (PubMed id 7693024)9 Hamamoto K....Sato T. (1993)
    1061. Abnormal plasma fibrinolysis in patients with rheumatoid arthritis and impaired endothelial fibrinolytic response in those complicated by vasculitis. (PubMed id 8239758)9 Lau C.S....Belch J.J. (1993)
    1062. Echicetin: a snake venom protein that inhibits binding of von Willebrand factor and alboaggregins to platelet glycoprotein Ib. (PubMed id 8481512)9 Peng M....Kirby E.P. (1993)
    1063. Pharmacokinetics of monoclonally-purified and recombinant factor VIII in patients with severe von Willebrand disease. (PubMed id 8236134)9 Morfini M....Arter A. (1993)
    1064. Addition of serum from patients with collagen diseases increases to cultured human endothelial cells production and release of von Willebrand factor. (PubMed id 8438904)9 Kagawa H....Yasunaga K. (1993)
    1065. Membrane fluidity and platelet aggregation: dibucaine permits ristocetin-induced platelet aggregation with low-molecular-weight von Willebrand multimers. (PubMed id 1420815)9 GjA...Brosstad F. (1992)
    1066. Clinical significance of the venous occlusion test on systemic lupus erythematosus patients with a focus on changes in blood levels of tissue plasminogen activator, von Willebrand factor antigen, and thrombomodulin. (PubMed id 1329422)9 Matsuda J....Kinoshita T. (1992)
    1067. Blood coagulation, fibrinolytic and inhibitory profil es in renal transplant recipients: comparison of cyclosporine and azathioprine. (PubMed id 1639529)9 Vaziri N.D....Gonzales E. (1992)
    1068. Adhesive protein expression on thrombin-stimulated platelets: time-dependent modulation of anti-fibrinogen, -fibronectin, and -von Willebrand factor antibody binding. (PubMed id 1737104)9 Peerschke E.I. (1992)
    1069. von Willebrand factor bound to glycoprotein Ib is cle ared from the platelet surface after platelet activation by thrombin. (PubMed id 1562727)9 HourdillAc P....Nurden A.T. (1992)
    1070. Angiotensin converting enzyme: an in vivo and in vitro marker of endothelial injury. (PubMed id 1325530)9 Matucci-Cerinic M....Kahaleh B. (1992)
    1071. Circulating thrombomodulin as a novel endothelial cell marker: comparison of its behavior with von Willebrand factor and tissue-type plasminogen activator. (PubMed id 1323930)9 Takahashi H....Shibata A. (1992)
    1072. The roles of protein kinase C and intracellular Ca2+ in the secretion of von Willebrand factor from human vascular endothelial cells. (PubMed id 1530595)9 Carew M.A....Pearson J.D. (1992)
    1073. A probable double heterozygous type II von Willebrand 's disease with increased ristocetin induced platelet aggregation. (PubMed id 1609773)9 Kinoshita S....Takamiya O. (1992)
    1074. Comparison of four virus-inactivated plasma concentrates for treatment of severe von Willebrand disease: a cross-over randomized trial. (PubMed id 1596562)9 Mannucci P.M....Rodeghiero F. (1992)
    1075. Identification of a new congenital defect of platelet function characterized by severe impairment of platelet responses to adenosine diphosphate. (PubMed id 1333302)9 Cattaneo M....Mannucci P.M. (1992)
    1076. Clinical significance of endothelial damage markers in essential mixed cryoglobulinemia. (PubMed id 1950376)9 Toschi V....Gibelli A. (1991)
    1077. Role of manganese in MG-63 osteosarcoma cell attachment to fibrinogen and von Willebrand factor. (PubMed id 1712876)9 Lampugnani M.G....Dejana E. (1991)
    1078. von Willebrand factor mediates protection of factor VIII from activated protein C-catalyzed inactivation. (PubMed id 1846615)9 Fay P.J....Walker F.J. (1991)
    1079. Site-directed mutagenesis of a soluble recombinant fr agment of platelet glycoprotein Ib alpha demonstrating negatively charged resid ues involved in von Willebrand factor binding. (PubMed id 1651333)9 Murata M....Ruggeri Z.M. (1991)
    1080. Changes in endothelial-related coagulation proteins in response to venous occlusion. (PubMed id 2057919)9 Jennings I....Harper P.L. (1991)
    1081. [Desmopressin in hemophilia A and Von Willebrand's disease] (PubMed id 1901629)9 Castro Cabezas M....Hart H.C. (1991)
    1082. Effects of desmopressin acetate on platelet aggregati on, von Willebrand factor, and blood loss after cardiac surgery with extracorpo real circulation. (PubMed id 2106402)9 Andersson T.L....Vinge E. (1990)
    1083. Inhibition of von Willebrand factor-induced platelet agglutination by ADP does not result from reduced binding of total von Willebrand factor or its larger multimers. (PubMed id 2401846)9 Zucker M.B....Mauss E.A. (1990)
    1084. Enhanced ristocetin-induced von Willebrand factor bin ding to platelet glycoprotein Ib in patients with steroid-responsive nephrotic syndrome. (PubMed id 2242824)9 Taira K....Fujimura Y. (1990)
    1085. Haemostatic measures in type 2 diabetic patients with microalbuminuria. (PubMed id 2142055)9 Schmitz A. and Ingerslev J. (1990)
    1086. Effect of platelet activation on the agglutination of platelets by von Willebrand factor. (PubMed id 2154674)9 Mills D.C....Kirby E.P. (1990)
    1087. Alterations of bone marrow sinusoidal endothelium in rat and patients with liver cirrhosis. (PubMed id 19333758)9 Zhao S....Zhang W.H. (2010)
    1088. Pivotal role of ADAMTS13 function in liver diseases. (PubMed id 20054668)9 Uemura M....Fukui H. (2010)
    1089. Loss of high-molecular-weight von Willebrand factor m ultimers mainly affects platelet aggregation in patients with aortic stenosis. (PubMed id 20024494)9 Panzer S....Lang I.M. (2010)
    1090. Role of local production of endothelium-derived nitri c oxide on cGMP signaling and S-nitrosylation. (PubMed id 19855060)9 Qian J....Fulton D.J. (2010)
    1091. Correlation between plasma asymmetric dimethylarginin e and different types of coronary heart disease. (PubMed id 20448350)9 Cao Y....Xiao L. (2010)
    1092. Involvement of platelet coagulation and inflammation in the endothelium of Schlemm's canal. (PubMed id 19696181)9 Watanabe Y....Murakami A. (2010)
    1093. Role of modulation of vascular endothelial growth fac tor and tumor necrosis factor-alpha in gastric ulcer healing in diabetic rats. (PubMed id 20144589)9 Baraka A.M....Gawad H.A. (2010)
    1094. Diagnosis of platelet-type von Willebrand disease by flow cytometry. (PubMed id 19951970)9 Giannini S....Gresele P. (2010)
    1095. Prognostic value of plasma von Willebrand factor-clea ving protease (ADAMTS13) antigen levels in patients with coronary artery disease. (PubMed id 20135067)9 Miura M....Ogawa H. (2010)
    1096. [Relationship of von Willebrand factor gene single-nu cleotide polymorphism with thrombosis diseases] (PubMed id 20416208)9 Yuan Z.H. and Zhu P. (2010)
    1097. Patients with antiphospholipid syndrome display endot helial perturbation. (PubMed id 19656656)9 Cugno M....Meroni P.L. (2010)
    1098. Idiopathic venous thrombosis is related to systemic i nflammatory response and to increased levels of circulating markers of endothel ial dysfunction. (PubMed id 20502419)9 Jezovnik M.K. and Poredos P. (2010)
    1099. Comparison of antiplatelet potency of sarpogrelate, a spirin, and beraprost in healthy volunteers according to in-vitro closure time. (PubMed id 20124989)9 Kim K.M....Kim S.B. (2010)
    1100. Desmopressin improves platelet dysfunction measured b y in vitro closure time in uremic patients. (PubMed id 20090366)9 Lee H.K....Kim S.B. (2010)
    1101. ADAMTS13 binds to CD36: a potential mechanism for platelet and endothelial localization of ADAMTS13. (PubMed id 19389207)9 Davis A.K....Dzik W.H. (2009)
    1102. [Effect of XueBiJing injection upon related proinflam matory factors and blood coagulation factors of vascular endothelial cells in s evere septic patients] (PubMed id 20137594)9 Li C.S....Wu C.J. (2009)
    1103. Causes, etiology and diagnosis of acquired von Willeb rand disease: a prospective diagnostic workup to establish the most effective t herapeutic strategies. (PubMed id 19506364)9 Sucker C....Zotz R.B. (2009)
    1104. A comprehensive assessment of endothelial function in overweight women with and without polycystic ovary syndrome. (PubMed id 18851710)9 Moran L.J....Teede H.J. (2009)
    1105. Atorvastatin improves endothelial function and cardia c performance in patients with dilated cardiomyopathy: the role of inflammation . (PubMed id 19636689)9 Liu M....Jin R. (2009)
    1106. Autoantibodies to heat shock protein 60 promote thrombus formation in a murine model of arterial thrombosis. (PubMed id 19192108)9 DieudAc M....Rauch J. (2009)
    1107. The distal carboxyl-terminal domains of ADAMTS13 are required for regulation of in vivo thrombus formation. (PubMed id 19109562)9 Banno F....Miyata T. (2009)
    1108. Reduced ADAMTS13 activity in delayed cerebral ischemi a after aneurysmal subarachnoid hemorrhage. (PubMed id 19584892)9 Vergouwen M.D....Meijers J.C. (2009)
    1109. Potential supplementary utility of combined PFA-100 a nd functional von Willebrand factor testing for the laboratory assessment of de smopressin and factor concentrate therapy in von Willebrand disease. (PubMed id 19584715)9 Favaloro E.J....Baker R. (2009)
    1110. Fibrinogen is required for maintenance of platelet in tracellular and cell-surface P-selectin expression. (PubMed id 19332769)9 Yang H....Ni H. (2009)
    1111. Eptifibatide does not suppress the increase of inflammatory markers in patients with non-ST-segment elevation acute coronary syndrome. (PubMed id 18163196)9 Mazaev A.A....Mazurov A.V. (2009)
    1112. Reduced von Willebrand factor survival in von Willebr and disease: pathophysiologic and clinical relevance. (PubMed id 19630772)9 Castaman G....Rodeghiero F. (2009)
    1113. Differential effect of extracellular acidosis on the release and dispersal of soluble and membrane proteins secreted from the Weibel-Palade body. (PubMed id 19258324)9 Babich V....Carter T. (2009)
    1114. Genetics of platelet reactivity in normal, healthy in dividuals. (PubMed id 19740098)9 Kunicki T.J....Nugent D.J. (2009)
    1115. Protein phosphatase 2B inhibition promotes the secret ion of von Willebrand factor from endothelial cells. (PubMed id 19344364)9 Nolasco L.H....Vijayan K.V. (2009)
    1116. Endothelial markers in schistosomiasis patients with or without portal hypertension. (PubMed id 18754093)9 de Toledo C.F....Borges D.R. (2009)
    1117. Optimizing treatment of von Willebrand disease by usi ng phenotypic and molecular data. (PubMed id 20008189)9 Rodeghiero F....Tosetto A. (2009)
    1118. Relevance of hemostatic risk factors on coronary morp hology in patients with diabetes mellitus type 2. (PubMed id 19419582)9 Jax T.W....Schoebel F.C. (2009)
    1119. Essential role of the disintegrin-like domain in ADAM TS13 function. (PubMed id 19234142)9 de Groot R....Crawley J.T. (2009)
    1120. Homocysteine and endothelial markers are increased in patients with chronic liver diseases. (PubMed id 19712849)9 RemkovA! A. and Remko M. (2009)
    1121. Genipin inhibits endothelial exocytosis via nitric oxide in cultured human umbilical vein endothelial cells. (PubMed id 19349964)9 Wang G.F....Zhang J.J. (2009)
    1122. Classification of inherited von Willebrand disease an d implications in clinical practice. (PubMed id 19944257)9 Federici A.B. (2009)
    1123. Platelet turnover, coagulation factors, and soluble markers of platelet and endothelial activation in essential thrombocythemia: relationship with thrombosis occurrence and JAK2 V617F allele burden. (PubMed id 19105233)9 Arellano-Rodrigo E....Cervantes F. (2009)
    1124. Aurintricarboxylic acid inhibits endothelial activation, complement activation, and von Willebrand factor secretion in vitro and attenuates hyperacute rejection in an ex vivo model of pig-to-human pulmonary xenotransplantation. (PubMed id 18957047)9 Kim H.K....Kim Y.T. (2008)
    1125. Expression patterns of adhesion molecules P-selectin, von Willebrand factor and PECAM-1 in lungs: a comparative study in cases of burn shock and hemorrhagic shock. (PubMed id 17597321)9 Weis A. and Bohnert M. (2008)
    1126. Predictors of inflammation in response to anthracycline-based chemotherapy for breast cancer. (PubMed id 17706918)9 Mills P.J....von KAonel R. (2008)
    1127. L1503R is a member of group I mutation and has dominant-negative effect on secretion of full-length VWF multimers: an analysis of two patients with type 2A von Willebrand disease. (PubMed id 18397285)9 Kashiwagi T....Kojima T. (2008)
    1128. Expression of vasohibin, an antiangiogenic factor, in human choroidal neovascular membranes. (PubMed id 18486097)9 Wakusawa R....Nishida K. (2008)
    1129. Measurement of hemostatic factors in EDTA plasma. (PubMed id 18854275)9 Green D....Tian L. (2008)
    1130. Diagnostic workup of patients with acquired von Willebrand syndrome: a retrospective single-centre cohort study. (PubMed id 18208537)9 Tiede A....Budde U. (2008)
    1131. The use of desmopressin in von Willebrand disease: the experience of the first 30 years (1977-2007). (PubMed id 18173689)9 Federici A.B. (2008)
    1132. Endothelial dysfunction and inflammation predict development of diabetic nephropathy in the Irbesartan in Patients with Type 2 Diabetes and Microalbuminuria (IRMA 2) study. (PubMed id 18609080)9 Persson F....Parving H.H. (2008)
    1133. Autonomic function and prothrombotic activity in women after an acute coronary event. (PubMed id 18788988)9 von KAonel R. and Orth-GomAcr K. (2008)
    1134. Shear stress and vascular smooth muscle cells promote endothelial differentiation of endothelial progenitor cells via activation of Akt. (PubMed id 17928113)9 Ye C....Jiang Z.L. (2008)
    1135. [Genetic polymorphism of von Willebrand factor (VWF)-cleaving protease, ADAMTS13] (PubMed id 19069166)9 Kokame K. (2008)
    1136. Impact of nebivolol on levels of serum nitric oxide, plasma von Willebrand factor and exercise stress testing parameters in hypertensive and ischemic heart disease patients. (PubMed id 18651401)9 Kobusiak-Prokopowicz M....Skalik R. (2008)
    1137. Successful surgical haemostasis in patients with von Willebrand disease with Koate DVI. (PubMed id 18445014)9 Viswabandya A....Srivastava A. (2008)
    1138. Soluble CD40 ligand and atrial fibrillation: relationship to platelet activation, and endothelial damage/dysfunction. (PubMed id 17555832)9 Blann A.D....Lip G.Y. (2008)
    1139. Prokineticin 2/Bv8 is expressed in Kupffer cells in liver and is down regulated in human hepatocellular carcinoma. (PubMed id 18300343)9 Monnier J....Samson M. (2008)
    1140. Nocturnal hypertension is associated with an exacerbation of the endothelial damage in preeclampsia. (PubMed id 18097134)9 Bouchlariotou S....Stefanidis I. (2008)
    1141. Walking, vigorous physical activity, and markers of hemostasis and inflammation in healthy men and women. (PubMed id 18248547)9 Hamer M. and Steptoe A. (2008)
    1142. The VWF/ADAMTS13 axis in the antiphospholipid syndrome: ADAMTS13 antibodies and ADAMTS13 dysfunction. (PubMed id 18341632)9 Austin S.K....Mackie I.J. (2008)
    1143. Genetics of hemostasis: differential effects of heritability and household components influencing lipid concentrations and clotting factor levels in 282 pediatric stroke families. (PubMed id 18560491)9 Nowak-GAPttl U....Stoll M. (2008)
    1144. Relationships of inflammatory and haemostatic markers with social class: results from a population-based study of older men. (PubMed id 17395187)9 Ramsay S....Wannamethee S.G. (2008)
    1145. Pre-treatment of porcine pulmonary xenograft with desmopressin: a novel strategy to attenuate platelet activation and systemic intravascular coagulation in an ex-vivo model of swine-to-human pulmonary xenotransplantation. (PubMed id 18333911)9 Kim Y.T....Kang H.J. (2008)
    1146. Extracorporeal shockwave therapy shows regeneration in hip necrosis. (PubMed id 18356180)9 Wang C.J....Yang Y.J. (2008)
    1147. Extensive contacts between ADAMTS13 exosites and von Willebrand factor domain A2 contribute to substrate specificity. (PubMed id 18492952)9 Gao W....Sadler J.E. (2008)
    1148. Properties of a concentrated minipool solvent-detergent treated cryoprecipitate processed in single-use bag systems. (PubMed id 18565126)9 Burnouf T....El-Ekiaby M. (2008)
    1149. Non-surgical bleeding in patients with ventricular as sist devices could be explained by acquired von Willebrand disease. (PubMed id 18282712)9 Geisen U....Zieger B. (2008)
    1150. Response to desmopressin is influenced by the genotype and phenotype in type 1 von Willebrand disease (VWD): results from the European Study MCMDM-1VWD. (PubMed id 18230755)9 Castaman G....Rodeghiero F. (2008)
    1151. [Coagulation activity of platelets] (PubMed id 17938762)9 Reininger A.J. (2007)
    1152. Thrombin-generating capacity in patients with von Willebrand's disease. (PubMed id 18055987)9 Rugeri L....Dargaud Y. (2007)
    1153. [The isolation, subculture and identification of human adipose derived endothelial progenitor cells] (PubMed id 17393699)9 Liu B....Cao Y.L. (2007)
    1154. Hemostatic response to acute physical exercise in healthy adolescents. (PubMed id 16844409)9 Ribeiro J....Duarte J. (2007)
    1155. Biochemical characterization of a recombinant von Willebrand factor (VWF) with combined type 2B and type 1 defects in the VWF gene in two patients with a type 2A phenotype of von Willebrand disease. (PubMed id 17155947)9 Baronciani L....Mannucci P.M. (2007)
    1156. A comparison of the associations between seven hemostatic or inflammatory variables and coronary heart disease. (PubMed id 17723116)9 Woodward M....Lowe G. (2007)
    1157. Plasma biomarkers of endothelial dysfunction in patients with hypertrophic cardiomyopathy. (PubMed id 18195461)9 Dimitrow P.P....Dubiel J.S. (2007)
    1158. Effects of 'newer' and 'older' antihypertensive drugs on hemorrheological, platelet, and endothelial factors. A substudy of the Anglo-Scandinavian Cardiac Outcomes Trial. (PubMed id 17531931)9 Spencer C.G....Lip G.Y. (2007)
    1159. Genetics of type 1 von Willebrand disease. (PubMed id 17934350)9 Goodeve A. (2007)
    1160. Menorrhagia associated with laboratory abnormalities of hemostasis: epidemiological, diagnostic and therapeutic aspects. (PubMed id 17635724)9 Kouides P.A. and Kadir R.A. (2007)
    1161. Inflammatory activation during coronary artery surgery and its dose-dependent modulation by statin/ACE-inhibitor combination. (PubMed id 17823365)9 Radaelli A....Ferrari A.U. (2007)
    1162. Purified A2 domain of von Willebrand factor binds to the active conformation of von Willebrand factor and blocks the interaction wit h platelet glycoprotein Ibalpha. (PubMed id 17389010)9 Martin C....Cruz M.A. (2007)
    1163. Long-term erythropoietin therapy does not affect endothelial markers, coagulation activation and oxidative stress in haemodialyzed patients. (PubMed id 17391740)9 Pawlak K....Mysliwiec M. (2007)
    1164. Altered platelet plug formation in hyperthyroidism and hypothyroidism. (PubMed id 17488803)9 Homoncik M....Vierhapper H. (2007)
    1165. Further characterization of ADAMTS-13 inactivation by thrombin. (PubMed id 17355572)9 Lam J.K....Crawley J.T. (2007)
    1166. von Willebrand factor, von Willebrand factor-cleaving protease, and shear stress. (PubMed id 17979694)9 Perutelli P. and Molinari A.C. (2007)
    1167. [Development of a novel ADAMTS13 activity assay for diagnosis of TMA and criteria for judgment of platelet transfusion] (PubMed id 17319494)9 Hiura H. (2007)
    1168. Coagulation markers in healthy human subjects exposed to diesel exhaust. (PubMed id 17321570)9 Carlsten C....Sullivan J.H. (2007)
    1169. Endothelial dysfunction, ambulatory pulse pressure and albuminuria are associated in Type 2 diabetic subjects. (PubMed id 17559428)9 Knudsen S.T....Poulsen P.L. (2007)
    1170. Antibody to human leukocyte antigen triggers endothelial exocytosis. (PubMed id 17229850)9 Yamakuchi M....Lowenstein C.J. (2007)
    1171. Periodontitis is characterized by elevated PAI-1 activity. (PubMed id 17535288)9 Bizzarro S....Loos B.G. (2007)
    1172. Platelet-type von Willebrand disease and type 2B von Willebrand disease: a story of nonidentical twins when two different genetic abnormalities evolve into similar phenotypes. (PubMed id 18175283)9 Othman M. (2007)
    1173. VWF/FVIII complex and the management of patient with inhibitors: from laboratory to clinical practice. (PubMed id 18078401)9 Berntorp E. (2007)
    1174. Treatment of urgent bleeding in von Willebrand disease. (PubMed id 17490729)9 Gill J.C. (2007)
    1175. Indices of angiogenesis, platelet activation, and endothelial damage/dysfunction in relation to ethnicity and coronary artery disease: differences in central versus peripheral levels. (PubMed id 17934908)9 Jaumdally R.J....Lip G.Y. (2007)
    1176. TTP and ADAMTS13: When Is Testing Appropriate? (PubMed id 18024619)9 Mannucci P.M. and Peyvandi F. (2007)
    1177. Plasma von Willebrand factor and soluble E-selectin levels in stable outpatients with systolic heart failure: the Frederiksberg heart failure study. (PubMed id 17027106)9 Chong A.Y....Lip G.Y. (2007)
    1178. Early-life and adult socioeconomic status and inflammatory risk markers in adulthood. (PubMed id 17225957)9 Pollitt R.A....Heiss G. (2007)
    1179. Thrombotic molecule expression in cerebral vascular malformations. (PubMed id 17646102)9 Storer K.P....Stoodley M.A. (2007)
    1180. The clinical utility of ADAMTS13 activity, antigen and autoantibody assays in thrombotic thrombocytopenic purpura. (PubMed id 17367414)9 Starke R....Mackie I. (2007)
    1181. Construction of tissue-engineered heart valves by using decellularized scaffolds and endothelial progenitor cells. (PubMed id 17517187)9 Fang N.T....Pan L.F. (2007)
    1182. Cerebral endothelial damage after severe head injury. (PubMed id 17965526)9 Yokota H. (2007)
    1183. von Willebrand factor mediates platelet spreading through glycoprotein Ib and alpha(IIb)beta3 in the presence of botrocetin and ristocetin, respectively. (PubMed id 16706984)9 McCarty O.J....Watson S.P. (2006)
    1184. Genetic polymorphisms G894T on the eNOS gene is associated with endothelial function and vWF levels in premature myocardial infarction survivors. (PubMed id 16337503)9 Antoniades C....Stefanadis C. (2006)
    1185. Association of cardiovascular risk factors with markers of endothelial dysfunction in middle-aged men and women. Results from the MONICA/KORA Augsburg Study. (PubMed id 16543972)9 Thorand B....Koenig W. (2006)
    1186. Laboratory identification of von Willebrand disease: technical and scientific perspectives. (PubMed id 16862518)9 Favaloro E.J. (2006)
    1187. Novel monoclonal antibody-based enzyme immunoassay for determining plasma levels of ADAMTS13 activity. (PubMed id 16934083)9 Kato S....Fujimura Y. (2006)
    1188. [Hemostatic markers of endothelial injury in ischaemic stroke caused by large or small vessel disease] (PubMed id 17345834)9 Iskra T....Szczudlik A. (2006)
    1189. The role of platelet adhesion receptor GPIbalpha far exceeds that of its main ligand, von Willebrand factor, in arterial thrombosis. (PubMed id 17075060)9 Bergmeier W....Wagner D.D. (2006)
    1190. Measurement of von Willebrand factor binding to a rec ombinant fragment of glycoprotein Ibalpha in an enzyme-linked immunosorbent ass ay-based method: performances in patients with type 2B von Willebrand disease. (PubMed id 16704443)9 Caron C....Mazurier C. (2006)
    1191. Apical sorting of ADAMTS13 in vascular endothelial cells and Madin-Darby canine kidney cells depends on the CUB domains and their association with lipid rafts. (PubMed id 16597588)9 Shang D....Zheng X.L. (2006)
    1192. Management of inherited von Willebrand disease in 2006. (PubMed id 16977571)9 Federici A.B. (2006)
    1193. Clustering of insulin resistance with vascular dysfunction and low-grade inflammation in type 2 diabetes. (PubMed id 16567539)9 Natali A....Ferrannini E. (2006)
    1194. Identification of amino acid residues essential for h eparin binding by the A1 domain of human von Willebrand factor. (PubMed id 16338223)9 Adachi T....Naoe T. (2006)
    1195. Differential effects of the loss of intrachain- versu s interchain-disulfide bonds in the cystine-knot domain of von Willebrand facto r on the clinical phenotype of von Willebrand disease. (PubMed id 17139364)9 Tjernberg P....Eikenboom J.C. (2006)
    1196. Differential regulation of endothelial exocytosis of P-selectin and von Willebrand factor by protease-activated receptors and cAMP. (PubMed id 16332977)9 Cleator J.H....Hamm H.E. (2006)
    1197. A minipool process for solvent-detergent treatment of cryoprecipitate at blood centres using a disposable bag system. (PubMed id 16756602)9 Burnouf T....El-Ekiaby M. (2006)
    1198. Effects of omega-3 polyunsaturated fatty acids on plasma indices of thrombogenesis and inflammation in patients post-myocardial infarction. (PubMed id 16154181)9 Lee K.W....Lip G.Y. (2006)
    1199. [Markers of endothelial dysfunction in patients with iodine induced hyperthyroidism] (PubMed id 16832784)9 Zonenberg A....GA^rska M. (2006)
    1200. Fibrinolytic dysfunction in insulin-resistant women with previous gestational diabetes. (PubMed id 16634839)9 Farhan S....Kautzky-Willer A. (2006)
    1201. Von Willebrand's disease: clinical management. (PubMed id 16684011)9 Federici A.B....Berntorp E. (2006)
    1202. Size regulation of von Willebrand factor-mediated platelet thrombi by ADAMTS13 in flowing blood. (PubMed id 16293606)9 Donadelli R....Ruggeri Z.M. (2006)
    1203. Oxidative stress, nitric oxide, endothelial dysfunction and tinnitus. (PubMed id 16753839)9 Neri S....Tsami A. (2006)
    1204. Platelet-activating factor synthesis and response on pancreatic islet endothelial cells: relevance for islet transplantation. (PubMed id 16495796)9 Biancone L....Camussi G. (2006)
    1205. Prophylaxis and von Willebrand's disease (vWD). (PubMed id 16580053)9 Abshire T.C. (2006)
    1206. Cold storage of citrated whole blood induces drastic time-dependent losses in factor VIII and von Willebrand factor: potential for m isdiagnosis of haemophilia and von Willebrand disease. (PubMed id 16607078)9 BAPhm M....Scharrer I. (2006)
    1207. Long-term behavior of endothelial and coagulation markers in Eisenmenger syndrome. (PubMed id 16708119)9 Caramuru L.H....Filho C.C. (2006)
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