Aliases for VWF Gene
External Ids for VWF Gene
Previous Symbols for VWF Gene
The glycoprotein encoded by this gene functions as both an antihemophilic factor carrier and a platelet-vessel wall mediator in the blood coagulation system. It is crucial to the hemostasis process. Mutations in this gene or deficiencies in this protein result in von Willebrand's disease. An unprocessed pseudogene has been found on chromosome 22. [provided by RefSeq, Jul 2008]
GeneCards Summary for VWF Gene
VWF (Von Willebrand Factor) is a Protein Coding gene. Diseases associated with VWF include qualitative platelet defect and type 2n von willebrand disease. Among its related pathways are PI3K-Akt signaling pathway and Signaling by GPCR. GO annotations related to this gene include protein homodimerization activity and protein N-terminus binding. An important paralog of this gene is OTOGL.
UniProtKB/Swiss-Prot for VWF Gene
Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma