VWDE Gene
protein-coding GIFtS: 36
GCID: GC07M012338
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von Willebrand factor D and EGF domains
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Aliases
for VWDE gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Von Willebrand Factor D And EGF Domains1 2 | | FLJ147121 | | Von Willebrand Factor D And EGF Domain-Containing Protein2 |
Export aliases for VWDE gene to outside databases |
Summaries
for VWDE gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for VWDE gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000007.13 NC_018918.1 NT_007819.17 NT_079592.2
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the VWDE gene promoter:
Sox5 FOXF2 SRF (504 AA) MEF-2 FOXD1 HNF-3beta MEF-2A SRY Sox9 aMEF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for VWDE
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat VWDE |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 7p21.3 Ensembl cytogenetic band: 7p21.3 HGNC cytogenetic band: 7p21.3VWDE Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07M012338: view genomic region
(about GC identifiers)
Start:
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12,370,509 bp from pter |
End:
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12,443,852 bp from pter |
Size:
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73,344 bases |
Orientation:
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minus strand |
1 alternative location:
| Chr7-,CRA_TCAG 12,423,482-12,496,820 |
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Proteins
for VWDE gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: VWDE_HUMAN, Q8N2E2 (See
protein sequence)Recommended Name: von Willebrand factor D and EGF domain-containing protein precursor Size: 1590 amino acids; 176780 Da
Subcellular location: Secreted (Potential)
Sequence caution: Sequence=BAB55237.1; Type=Erroneous initiation; Note=Translation N-terminally extended;Sequence=BAC11671.1; Type=Miscellaneous discrepancy; Note=Intron retention; Sequence=EAW93644.1; Type=Erroneous genemodel prediction;
Secondary accessions: Q96SQ3Explore the universe of human proteins at neXtProt for VWDE: NX_Q8N2E2
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8N2E2
VWDE Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001129396.1
ENSEMBL proteins: ENSP00000275358 ENSP00000428810 ENSP00000401687 ENSP00000317143
Human Recombinant Protein Products for VWDE:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005576 | extracellular region |
IEA | -- |
VWDE for ontologies About GeneDecksing
VWDE Antibody Products:
Assay Products for VWDE: |
Protein
Domains /
Families
for VWDE gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
VWDE for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8N2E2ProtoNet protein and cluster: Q8N2E2 UniProtKB/Swiss-Prot: VWDE_HUMAN, Q8N2E2Similarity: Contains 7 EGF-like domainsSimilarity: Contains 1 VWFD domain |
Function
for VWDE gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for VWDE (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for VWDE
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: VWDE (NM_001135924) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for VWDE | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VWDE |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VWDE |
|
Pathways & Interactions
for VWDE gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for VWDE
|
Drugs & Compounds
for VWDE gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for VWDE
Search CenterWatch for drugs/clinical trials and news about VWDE
|
Transcripts
for VWDE gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for VWDE gene: NM_001135924.1 Unigene Cluster for VWDE: Von Willebrand factor D and EGF domains Hs.669526 [show with all ESTs]Unigene Representative Sequence: BC1443165 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000275358 ENST00000485526 ENST00000521169(uc011jxm.1) ENST00000452576(uc003ssj.2 uc011jxl.1)
ENST00000326715
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for VWDE (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for VWDE
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: VWDE (NM_001135924) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for VWDE | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VWDE |
Additional cDNA sequence: AK027618.1 BC144316.1 BC144319.1 5 DOTS entries: DT.70104089 DT.100721192 DT.40276112 DT.121100373 DT.91804215 4 AceView cDNA sequences: CD656912 AA083940 AK075525 AA083838
GeneLoc Exon Structure
|
Expression
for VWDE gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| VWDE expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See VWDE Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for VWDE
SOURCE GeneReport for Unigene cluster: Hs.669526
SABiosciences Custom PCR Arrays for VWDE
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for VWDE
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat VWDE | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat VWDE | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat VWDE | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VWDE |
Orthologs
for VWDE gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for VWDE gene from 4/12 species (see all 12) About this table
ENSEMBL Gene Tree for VWDE (if available)
TreeFam Gene Tree for VWDE (if available) |
Paralogs
for VWDE gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for VWDE gene
- TENM22 WIF12 TENM12 TENM42 TENM32
5 SIMAP similar genes for VWDE using alignment to 4 protein entries: VWDE_HUMAN (see all proteins):CUBN WIF1 PROS1 NTNG1 SNED1
VWDE for paralogs About GeneDecksing
|
Genomic Variants
for VWDE gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 7 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for VWDE (12370509 - 12443852 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for VWDE: -- | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for VWDE gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 VWDE for disorders About MalaCards
VWDE for disorders About GeneDecksing
Human Genome Epidemiology (HuGE) Navigator: VWDE (1 document)
Export disorders for VWDE gene to outside databases
|
Publications
for VWDE gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for VWDE gene integrated from 9 sources:
(articles sorted by number of sources associating them with VWDE) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1, 2, 3 Otsuki T....Isogai T. (2005)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2, 3 Ota T.... Sugano S. (2004)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- The DNA sequence of human chromosome 7. (PubMed id 12853948)2 Hillier L.W.... Wilson R.K. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for VWDE gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing VWDE gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing VWDE gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing VWDE gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for VWDE | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for VWDE gene:
Search GeneIP for patents involving VWDE
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for VWDE gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for VWDE | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for VWDE | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for VWDE | | | OriGene Protein Over-expression Lysate for VWDE | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for VWDE | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for VWDE | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for VWDE | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for VWDE | | OriGene Custom Protein Services for VWDE | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat VWDE | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing VWDE | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat VWDE | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat VWDE | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat VWDE | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat VWDE |
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 |  |  |  | |
| | | | Search Tocris compounds for VWDE |
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 | | | VWDE Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VWDE |
|  |  |  |  | | | | Search ThermoFisher Antibodies for VWDE |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VWDE |
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