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Aliases for VWDE Gene

Aliases for VWDE Gene

  • Von Willebrand Factor D And EGF Domains 2 3

External Ids for VWDE Gene

Summaries for VWDE Gene

GeneCards Summary for VWDE Gene

VWDE (Von Willebrand Factor D And EGF Domains) is a Protein Coding gene. An important paralog of this gene is WIF1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VWDE Gene

Genomics for VWDE Gene

Genomic Location for VWDE Gene

Start:
12,330,883 bp from pter
End:
12,404,226 bp from pter
Size:
73,344 bases
Orientation:
Minus strand

Genomic View for VWDE Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for VWDE Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VWDE Gene

Regulatory Elements for VWDE Gene

Proteins for VWDE Gene

  • Protein details for VWDE Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N2E2-VWDE_HUMAN
    Recommended name:
    von Willebrand factor D and EGF domain-containing protein
    Protein Accession:
    Q8N2E2
    Secondary Accessions:
    • B7ZM77
    • Q96SQ3

    Protein attributes for VWDE Gene

    Size:
    1590 amino acids
    Molecular mass:
    176780 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAI44320.1; Type=Frameshift; Positions=1487; Evidence={ECO:0000305}; Sequence=BAB55237.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAC11671.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305}; Sequence=EAW93644.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for VWDE Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for VWDE Gene

Proteomics data for VWDE Gene at MOPED

Post-translational modifications for VWDE Gene

  • Glycosylation at Asn367, Asn703, and Asn968

Other Protein References for VWDE Gene

No data available for DME Specific Peptides for VWDE Gene

Domains for VWDE Gene

Protein Domains for VWDE Gene

UniProtKB/Swiss-Prot:

VWDE_HUMAN
Domain:
  • Contains 7 EGF-like domains.:
    • Q8N2E2
  • Contains 1 VWFD domain.:
    • Q8N2E2
genes like me logo Genes that share domains with VWDE: view

No data available for Gene Families for VWDE Gene

Function for VWDE Gene

Gene Ontology (GO) - Molecular Function for VWDE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with VWDE: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for VWDE Gene

Localization for VWDE Gene

Subcellular locations from UniProtKB/Swiss-Prot for VWDE Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for VWDE Gene COMPARTMENTS Subcellular localization image for VWDE gene
Compartment Confidence
extracellular 3
plasma membrane 3
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for VWDE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0016020 membrane --
genes like me logo Genes that share ontologies with VWDE: view

Pathways for VWDE Gene

SuperPathways for VWDE Gene

No Data Available

Interacting Proteins for VWDE Gene

Gene Ontology (GO) - Biological Process for VWDE Gene

None

No data available for Pathways by source for VWDE Gene

Transcripts for VWDE Gene

mRNA/cDNA for VWDE Gene

(4) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for VWDE Gene

Von Willebrand factor D and EGF domains:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for VWDE Gene

No ASD Table

Relevant External Links for VWDE Gene

GeneLoc Exon Structure for
VWDE
ECgene alternative splicing isoforms for
VWDE

Expression for VWDE Gene

mRNA expression in normal human tissues for VWDE Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for VWDE Gene

This gene is overexpressed in Pituitary (14.6) and Heart - Atrial Appendage (8.0).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for VWDE Gene

SOURCE GeneReport for Unigene cluster for VWDE Gene Hs.669526

genes like me logo Genes that share expressions with VWDE: view

Orthologs for VWDE Gene

This gene was present in the common ancestor of animals.

Orthologs for VWDE Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia VWDE 36
  • 98.95 (n)
  • 97.86 (a)
VWDE 37
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia VWDE 36
  • 84.05 (n)
  • 76.71 (a)
dog
(Canis familiaris)
Mammalia VWDE 36
  • 86.43 (n)
  • 80.98 (a)
VWDE 37
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Vwde 36
  • 79.06 (n)
  • 73.36 (a)
Vwde 16
Vwde 37
  • 72 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 37 (a)
OneToMany
-- 37
  • 61 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 3 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Vwde 36
  • 79.44 (n)
  • 74.14 (a)
chicken
(Gallus gallus)
Aves VWDE 36
  • 68.93 (n)
  • 62.19 (a)
VWDE 37
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 76 (a)
OneToMany
-- 37
  • 60 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia vwde 36
  • 64.75 (n)
  • 59.17 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100006681 36
  • 58.73 (n)
  • 53.78 (a)
VWDE 37
  • 45 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta shf 37
  • 26 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea T01D3.1 37
  • 8 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 33 (a)
OneToOne
Species with no ortholog for VWDE:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for VWDE Gene

ENSEMBL:
Gene Tree for VWDE (if available)
TreeFam:
Gene Tree for VWDE (if available)

Paralogs for VWDE Gene

Paralogs for VWDE Gene

Selected SIMAP similar genes for VWDE Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with VWDE: view

Variants for VWDE Gene

Sequence variations from dbSNP and Humsavar for VWDE Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs1888 -- 12,377,635(+) TATTA(C/G)TAATA intron-variant
rs702473 -- 12,390,693(-) TTGCC(C/T)ATTTG intron-variant
rs847990 -- 12,406,097(-) AGACA(C/T)AGATT upstream-variant-2KB
rs847991 -- 12,402,952(-) GACTT(G/T)TTCTT intron-variant
rs847992 -- 12,402,212(-) agaac(A/G)tattt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for VWDE Gene

Variant ID Type Subtype PubMed ID
dgv7191n71 CNV Loss 21882294
dgv7192n71 CNV Gain 21882294
nsv464371 CNV Gain 19166990
nsv887634 CNV Gain 21882294
nsv470044 CNV Loss 18288195
nsv887635 CNV Loss 21882294
nsv464374 CNV Loss 19166990
dgv7193n71 CNV Loss 21882294
nsv516511 CNV Loss 19592680

Relevant External Links for VWDE Gene

HapMap Linkage Disequilibrium report
VWDE

Disorders for VWDE Gene

Relevant External Links for VWDE

Genetic Association Database (GAD)
VWDE
Human Genome Epidemiology (HuGE) Navigator
VWDE
genes like me logo Genes that share disorders with VWDE: view

No data available for UniProtKB/Swiss-Prot for VWDE Gene

Publications for VWDE Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 2 3 4
  2. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PMID: 16303743) Otsuki T. … Isogai T. (DNA Res. 2005) 2 3 4
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 49
  4. Proteomic identification of common SCF ubiquitin ligase FBXO6-interacting glycoproteins in three kinds of cells. (PMID: 22268729) Liu B. … Wang L.S. (J. Proteome Res. 2012) 3
  5. Genetic association with overall survival of taxane-treated lung cancer patients - a genome-wide association study in human lymphoblastoid cell lines followed by a clinical association study. (PMID: 23006423) Niu N. … Wang L. (BMC Cancer 2012) 3

Products for VWDE Gene

Sources for VWDE Gene

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