Free for academic non-profit institutions. Other users need a Commercial license

Aliases for VWCE Gene

Aliases for VWCE Gene

  • Von Willebrand Factor C And EGF Domains 2 3 5
  • HBV X Protein Up-Regulated Gene 11 Protein 3 4
  • HBxAg Up-Regulated Gene 11 Protein 3 4
  • URG11 3 4
  • VWC1 3

External Ids for VWCE Gene

Previous GeneCards Identifiers for VWCE Gene

  • GC11M060783
  • GC11M061025
  • GC11M057353

Summaries for VWCE Gene

GeneCards Summary for VWCE Gene

VWCE (Von Willebrand Factor C And EGF Domains) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is KCP.

UniProtKB/Swiss-Prot for VWCE Gene

  • May be a regulatory element in the beta-catenin signaling pathway and a target for chemoprevention of hapatocellular carcinoma.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VWCE Gene

Genomics for VWCE Gene

Regulatory Elements for VWCE Gene

Enhancers for VWCE Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around VWCE on UCSC Golden Path with GeneCards custom track

Promoters for VWCE Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around VWCE on UCSC Golden Path with GeneCards custom track

Genomic Location for VWCE Gene

61,258,286 bp from pter
61,295,424 bp from pter
37,139 bases
Minus strand

Genomic View for VWCE Gene

Genes around VWCE on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
VWCE Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for VWCE Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VWCE Gene

Proteins for VWCE Gene

  • Protein details for VWCE Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    von Willebrand factor C and EGF domain-containing protein
    Protein Accession:
    Secondary Accessions:
    • A5PKV0
    • Q7Z7L6
    • Q86WK8

    Protein attributes for VWCE Gene

    955 amino acids
    Molecular mass:
    99915 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAO47606.1; Type=Frameshift; Positions=210, 232, 745, 761, 769, 837, 912; Evidence={ECO:0000305};

    Alternative splice isoforms for VWCE Gene


neXtProt entry for VWCE Gene

Proteomics data for VWCE Gene at MOPED

Post-translational modifications for VWCE Gene

  • Glycosylation at Asn 462, Asn 472, and Ser 885
  • Modification sites at PhosphoSitePlus

Other Protein References for VWCE Gene

No data available for DME Specific Peptides for VWCE Gene

Domains & Families for VWCE Gene

Suggested Antigen Peptide Sequences for VWCE Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 4 EGF-like domains.
  • Contains 4 EGF-like domains.
  • Contains 6 VWFC domains.
genes like me logo Genes that share domains with VWCE: view

No data available for Gene Families for VWCE Gene

Function for VWCE Gene

Molecular function for VWCE Gene

UniProtKB/Swiss-Prot Function:
May be a regulatory element in the beta-catenin signaling pathway and a target for chemoprevention of hapatocellular carcinoma.
UniProtKB/Swiss-Prot Induction:
By HBxAg.
genes like me logo Genes that share phenotypes with VWCE: view

Animal Model Products

  • Taconic Biosciences Mouse Models for VWCE

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for VWCE Gene

Localization for VWCE Gene

Subcellular locations from UniProtKB/Swiss-Prot for VWCE Gene

Secreted. Note=According to PubMed:16496348 is localized in the cytoplasm. {ECO:0000269 PubMed:16496348}.

Subcellular locations from

Jensen Localization Image for VWCE Gene COMPARTMENTS Subcellular localization image for VWCE gene
Compartment Confidence
extracellular 4
plasma membrane 4
cytosol 2
nucleus 2

No data available for Gene Ontology (GO) - Cellular Components for VWCE Gene

Pathways & Interactions for VWCE Gene

SuperPathways for VWCE Gene

No Data Available

Interacting Proteins for VWCE Gene

Gene Ontology (GO) - Biological Process for VWCE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009966 regulation of signal transduction IEA --
genes like me logo Genes that share ontologies with VWCE: view

No data available for Pathways by source and SIGNOR curated interactions for VWCE Gene

Drugs & Compounds for VWCE Gene

No Compound Related Data Available

Transcripts for VWCE Gene

Unigene Clusters for VWCE Gene

Von Willebrand factor C and EGF domains:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for VWCE Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b · 15c ^ 16 ^ 17 ^ 18 ^ 19 ^ 20
SP1: -
SP2: - -

Relevant External Links for VWCE Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for VWCE Gene

mRNA expression in normal human tissues for VWCE Gene

mRNA differential expression in normal tissues according to GTEx for VWCE Gene

This gene is overexpressed in Liver (x9.7) and Ovary (x5.1).

Protein differential expression in normal tissues from HIPED for VWCE Gene

This gene is overexpressed in Placenta (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for VWCE Gene

SOURCE GeneReport for Unigene cluster for VWCE Gene Hs.60640

mRNA Expression by UniProt/SwissProt for VWCE Gene

Tissue specificity: Expressed in liver.
genes like me logo Genes that share expression patterns with VWCE: view

Protein tissue co-expression partners for VWCE Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for VWCE Gene

Orthologs for VWCE Gene

This gene was present in the common ancestor of animals.

Orthologs for VWCE Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia VWCE 35
  • 84.51 (n)
  • 82.93 (a)
  • 83 (a)
(Canis familiaris)
Mammalia VWCE 35
  • 84.58 (n)
  • 82.57 (a)
  • 81 (a)
(Mus musculus)
Mammalia Vwce 35
  • 80.76 (n)
  • 79.29 (a)
Vwce 16
Vwce 36
  • 79 (a)
(Pan troglodytes)
Mammalia VWCE 35
  • 98.6 (n)
  • 98.09 (a)
  • 98 (a)
(Rattus norvegicus)
Mammalia Vwce 35
  • 79.49 (n)
  • 77.8 (a)
(Monodelphis domestica)
Mammalia VWCE 36
  • 72 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 56 (a)
-- 36
  • 30 (a)
-- 36
  • 29 (a)
-- 36
  • 75 (a)
(Gallus gallus)
Aves VWCE 36
  • 58 (a)
(Anolis carolinensis)
Reptilia VWCE 36
  • 67 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100488202 35
  • 58.35 (n)
  • 54.32 (a)
(Danio rerio)
Actinopterygii VWCE 36
  • 23 (a)
(Caenorhabditis elegans)
Secernentea mua-3 36
  • 6 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 5 (a)
Species with no ortholog for VWCE:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for VWCE Gene

Gene Tree for VWCE (if available)
Gene Tree for VWCE (if available)

Paralogs for VWCE Gene

Paralogs for VWCE Gene Pseudogenes for VWCE Gene

genes like me logo Genes that share paralogs with VWCE: view

Variants for VWCE Gene

Sequence variations from dbSNP and Humsavar for VWCE Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs3750982 - 61,259,018(+) GTCGA(C/G)GGGAG downstream-variant-500B, reference, missense
rs1048498 -- 61,258,506(-) CCCAA(A/G)AAGTG utr-variant-3-prime
rs1108769 -- 61,287,420(-) TGCCC(G/T)TTTGA intron-variant
rs1815842 -- 61,265,755(+) ATGAA(C/G)AATTT intron-variant
rs2001746 -- 61,266,053(-) ATTTT(A/T)TTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for VWCE Gene

Variant ID Type Subtype PubMed ID
nsv428259 CNV Gain+Loss 18775914
dgv390e1 CNV Complex 17122850
nsv832177 CNV Loss 17160897
nsv341 CNV Insertion 18451855
esv28446 CNV Loss 19812545
nsv509415 CNV Insertion 20534489
nsv8834 CNV Gain+Loss 18304495

Variation tolerance for VWCE Gene

Residual Variation Intolerance Score: 32.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.00; 49.87% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for VWCE Gene

Disorders for VWCE Gene

Relevant External Links for VWCE

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for VWCE Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for VWCE Gene

Publications for VWCE Gene

  1. Enhanced cell survival of Hep3B cells by the hepatitis B x antigen effector, URG11, is associated with upregulation of beta-catenin. (PMID: 16496348) Lian Z. … Feitelson M.A. (Hepatology 2006) 3 4 67
  2. Upregulated expression of a unique gene by hepatitis B x antigen promotes hepatocellular growth and tumorigenesis. (PMID: 12869306) Lian Z. … Feitelson M.A. (Neoplasia 2003) 2 3
  3. [Increased expression URG11 in hepatocellular carcinoma tissues promotes the growth of hepatocellular carcinoma cells]. (PMID: 26522362) Xie H. … Liu J. (Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2015) 3
  4. URG11 predicts poor prognosis of pancreatic cancer by enhancing epithelial-mesenchymal transition-driven invasion. (PMID: 24930007) Peng W. … Liu J. (Med. Oncol. 2014) 3
  5. Association of URG11 and Twist with clinical pathological characteristics and prognosis in patients with IgA nephropathy. (PMID: 23828164) Du R. … Sun S. (Nephrol. Dial. Transplant. 2013) 3

Products for VWCE Gene

Sources for VWCE Gene