Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

VWCE Gene

protein-coding   GIFtS: 41
GCID: GC11M061025

Von Willebrand Factor C And EGF Domains

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Von Willebrand Factor C And EGF Domains1 2
URG112 3 5
HBV X Protein Up-Regulated Gene 11 Protein2 3
HBxAg Up-Regulated Gene 11 Protein2 3
VWC12 5
Von Willebrand Factor C And EGF Domain-Containing Protein2

External Ids:    HGNC: 264871   Entrez Gene: 2200012   Ensembl: ENSG000001679927   OMIM: 6111155   UniProtKB: Q96DN23   

Export aliases for VWCE gene to outside databases

Previous GC identifers: GC11M060783 GC11M057353


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for VWCE Gene: 
VWCE (von Willebrand factor C and EGF domains) is a protein-coding gene. Diseases associated with VWCE include hepatitis b, and hypoxia. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is EGFL6.

UniProtKB/Swiss-Prot: VWCE_HUMAN, Q96DN2
Function: May be a regulatory element in the beta-catenin signaling pathway and a target for chemoprevention of
hapatocellular carcinoma




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NT_167190.1  NC_018922.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the VWCE gene promoter:
         Sp1   AML1a   Tal-1   AP-4   AP-2gamma   E47   CREB   deltaCREB   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidVWCE promoter sequence
   Search SABiosciences Chromatin IP Primers for VWCE

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat VWCE


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q12.2   Ensembl cytogenetic band:  11q12.2   HGNC cytogenetic band: 11q12.2

VWCE Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
VWCE gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M061025:  view genomic region     (about GC identifiers)

Start:
61,025,758 bp from pter      End:
61,062,896 bp from pter
Size:
37,139 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: VWCE_HUMAN, Q96DN2 (See protein sequence)
Recommended Name: von Willebrand factor C and EGF domain-containing protein precursor  
Size: 955 amino acids; 99915 Da
Subcellular location: Secreted (Potential). Note=According to PubMed:16496348 is localized in the cytoplasm
Sequence caution: Sequence=AAO47606.1; Type=Frameshift; Positions=210, 232, 745, 761, 769, 837, 912;
Secondary accessions: A5PKV0 Q7Z7L6 Q86WK8
Alternative splicing: 2 isoforms:  Q96DN2-1   Q96DN2-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for VWCE: NX_Q96DN2

Explore proteomics data for VWCE at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96DN2

  • VWCE Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    VWCE Protein Expression
    REFSEQ proteins: NP_689931.2  
    ENSEMBL proteins: 
     ENSP00000301770   ENSP00000334186   ENSP00000442570   ENSP00000441565  

    Human Recombinant Protein Products for VWCE: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for VWCE
    GenScript Custom Purified and Recombinant Proteins Services for VWCE
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--

    VWCE for ontologies           About GeneDecksing



    VWCE Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for VWCE
    GenScript Custom Superior Antibodies Services for VWCE
    Search for Antibodies for VWCE at Abcam
    Browse Antibodies at Cloud-Clone Corp. 
    Search ThermoFisher Antibodies for VWCE
    Search LSBio for Antibodies for VWCE 

    Assay Products for VWCE: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for VWCE
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for VWCE
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/6 InterPro protein domains (see all 6):
     IPR001881 EGF-like_Ca-bd
     IPR000742 EG-like_dom
     IPR013032 EGF-like_CS
     IPR000152 EGF-type_Asp/Asn_hydroxyl_site
     IPR018097 EGF_Ca-bd_CS

    Graphical View of Domain Structure for InterPro Entry Q96DN2

    ProtoNet protein and cluster: Q96DN2

    3 Blocks protein domains:
    IPB000152 Aspartic acid and asparagine hydroxylation site
    IPB001007 von Willebrand factor
    IPB001881 EGF-like calcium-binding


    UniProtKB/Swiss-Prot: VWCE_HUMAN, Q96DN2
    Similarity: Contains 4 EGF-like domains
    Similarity: Contains 6 VWFC domains


    VWCE for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: VWCE_HUMAN, Q96DN2
    Function: May be a regulatory element in the beta-catenin signaling pathway and a target for chemoprevention of
    hapatocellular carcinoma
    Induction: By HBxAg

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding ----
         
    VWCE for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for VWCE:
     Decreased viability 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for VWCE 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for VWCE

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for VWCE 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for VWCE 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat VWCE
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate VWCE
    SwitchGear 3'UTR luciferase reporter plasmidVWCE 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for VWCE
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat VWCE

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for VWCE
    Sirion Biotech Customized adenovirus for overexpression of VWCE

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for VWCE (see all 7)
    OriGene ORF clones in mouse, rat for VWCE
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: VWCE (NM_152718)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for VWCE
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VWCE
    Sirion Biotech Customized lentivirus for stable overexpression of VWCE 
                         Customized lentivirus expression plasmids for stable overexpression of VWCE 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for VWCE
    Search LifeMap BioReagents cell lines for VWCE
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VWCE


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for VWCE

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for VWCE

    Search CenterWatch for drugs/clinical trials and news about VWCE

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for VWCE gene: 
    NM_152718.2  

    Unigene Cluster for VWCE:

    Von Willebrand factor C and EGF domains
    Hs.60640  [show with all ESTs]
    Unigene Representative Sequence: NM_152718
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000301770 ENST00000335613(uc001nra.3 uc001nrb.3) ENST00000535710
    ENST00000538438 ENST00000398808 ENST00000535599 ENST00000538579
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat VWCE
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate VWCE
    SwitchGear 3'UTR luciferase reporter plasmidVWCE 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for VWCE
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat VWCE
    Clone
    Products:
         
    OriGene clones in human, mouse for VWCE (see all 7)
    OriGene ORF clones in mouse, rat for VWCE
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: VWCE (NM_152718)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for VWCE
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VWCE
    Sirion Biotech Customized lentivirus for stable overexpression of VWCE 
                         Customized lentivirus expression plasmids for stable overexpression of VWCE 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for VWCE
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat VWCE
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat VWCE
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat VWCE

    Additional mRNA sequence: 

    AK056571.1 AK299583.1 AK302241.1 BC042143.1 BC052564.1 BC077719.1 BC142624.1 

    5 DOTS entries:

    DT.100778136  DT.207448  DT.207449  DT.100715608  DT.120754830 

    24/54 AceView cDNA sequences (see all 54):

    BQ066320 BC052564 CB988642 AK056571 BC077719 BE464430 H74100 BC042143 
    BQ653752 BM694786 NM_152718 BQ642831 AA328361 CD637970 BX283551 BU731294 
    BQ641995 AY205235 CD637960 AW081236 CD637963 CB240652 BQ644098 CD637965 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for VWCE    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b · 15c ^ 16 ^ 17 ^ 18 ^ 19 ^ 20
    SP1:                                                                                            -                                             
    SP2:                                                                                            -     -                                       
    SP3:                                                                                                                                          


    ECgene alternative splicing isoforms for VWCE

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    VWCE expression in normal human tissues (normalized intensities)      VWCE embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CGTCTCTCTG
    VWCE Expression
    About this image


    VWCE expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/6 selected tissues (see all 6) fully expand
     
     Mesenchymal Stem Cells (Integumentary System)    fully expand to see all 4 entries
             Human Mesenchymal Stem Cells (hMSC)-1   
     
     Endothelium (Cardiovascular System)    fully expand to see all 3 entries
             PureStem endothelial progenitor 30-SM2-1
     
     Heart (Cardiovascular System)
             Human Cardiac Fibroblasts-adult ventrical (HCF-av)   
     
     Tooth
             Dental pulp Stem Cells (DPSC)   
     
     Blood (Hematopoietic System)
             PureStem endothelial progenitor 30-MV2-12

    See VWCE Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for VWCE

    SOURCE GeneReport for Unigene cluster: Hs.60640

    UniProtKB/Swiss-Prot: VWCE_HUMAN, Q96DN2
    Tissue specificity: Expressed in liver

        SABiosciences Custom PCR Arrays for VWCE
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for VWCE
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat VWCE
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat VWCE
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat VWCE
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VWCE

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for VWCE gene from 3/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Vwce1 , 5 von Willebrand factor C and EGF domains1, 5 80.76(n)1
    79.29(a)1
      19 (6.87 cM)5
    717681  NM_027913.11  NP_082189.11 
     106342335 
    chicken
    (Gallus gallus)
    Aves VWCE6
    von Willebrand factor C and EGF domains
    58(a)
    1 ↔ 1
    5(406183-412683)
    lizard
    (Anolis carolinensis)
    Reptilia VWCE6
    Uncharacterized protein
    65(a)
    1 ↔ 1
    GL343235.1(706284-741993)


    ENSEMBL Gene Tree for VWCE (if available)
    TreeFam Gene Tree for VWCE (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for VWCE gene
    EGFL62  NPNT2  

    VWCE for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for VWCE
    PGOHUM00000260288 PGOHUM00000260289


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/835 SNPs in VWCE are shown (see all 835)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1395526671,2
    --57392644(+) ATACAA/CAGAAC 1 -- us2k10--------
    rs744008921,2
    C--61025288(-) GCTCCC/AACTTA 1 -- ds50013Minor allele frequency- A:0.17NA 6
    rs122802391,2
    C,H--61025343(+) ctgggG/Ttctat 1 -- ds50015Minor allele frequency- T:0.00NS EA NA 422
    rs1139968721,2
    C--61025470(+) TTTAAC/GTATAT 1 -- ds50010--------
    rs617429211,2
    C,F--61025737(+) GTAAGC/TGGTGA 1 -- ds50011Minor allele frequency- T:0.02NS 60
    rs1425015971,2
    --61025738(+) TAAGCA/GGTGAA 1 -- ds50010--------
    rs1459378551,2
    C--61025921(+) CCAGGC/GAGGAT 1 -- ut310--------
    rs1385036101,2
    --61026017(+) TTCCAC/TCCTCA 1 -- ut310--------
    rs112306481,2
    C,F,H--61026130(+) TCTCCC/TGGACA 1 -- ut31 ese310Minor allele frequency- T:0.01NS EA NA EU 2271
    rs1831147941,2
    C--61026131(+) CTCCCA/GGACAC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for VWCE (61025758 - 61062896 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for VWCE:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv341CNV Insertion18451855
    nsv509415CNV Insertion20534489
    nsv832177CNV Loss17160897
    esv28446CNV Loss19812545
    nsv428259CNV Gain+Loss18775914
    nsv8834CNV Gain+Loss18304495
    dgv390e1CNV Complex17122850

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing VWCE
    DNA2.0 Custom Variant and Variant Library Synthesis for VWCE

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 611115    OMIM disorders: --

    4 diseases for VWCE:    About MalaCards
    hepatitis b    hypoxia    gastric cancer    hepatitis


    VWCE for disorders           About GeneDecksing


    Export disorders for VWCE gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for VWCE gene integrated from 9 sources:
    (articles sorted by number of sources associating them with VWCE)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Enhanced cell survival of Hep3B cells by the hepatitis B x antigen effector, URG11, is associated with upregulation of beta-catenin. (PubMed id 16496348)1, 2 Lian Z....Feitelson M.A. (2006)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. Upregulated expression of a unique gene by hepatitis B x antigen promotes hepatocellular growth and tumorigenesis. (PubMed id 12869306)1, 3 Lian Z....Feitelson M.A. (2003)
    4. URG11 promotes gastric cancer growth and invasion by activation of beta-catenin signalling pathway. (PubMed id 19413886)1 Du R....Fan D. (2010)
    5. URG11 mediates hypoxia-induced epithelial-to-mesenchy mal transition by modulation of E-cadherin and beta-catenin. (PubMed id 19900406)1 Du R....Fan D. (2010)
    6. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    9. Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence. (PubMed id 7566098)1 Adams M.D....White O. (1995)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 220001 HGNC: 26487 AceView: FLJ32009 Ensembl:ENSG00000167992 euGenes: HUgn220001
    ECgene: VWCE H-InvDB: VWCE

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for VWCE Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for VWCE gene:
    Search GeneIP for patents involving VWCE

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for VWCE  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for VWCE  
     OriGene qSTAR qPCR primer pairs in human, mouse for VWCE   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for VWCE   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for VWCE   OriGene Custom Protein Services for VWCE  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat VWCE
     QIAGEN SeqTarget long-range PCR primers for resequencing VWCE
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat VWCE
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat VWCE
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat VWCE
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat VWCE
     GenScript Custom Purified and Recombinant Proteins Services for VWCE GenScript cDNA clones with any tag delivered in your preferred vector for VWCE
     GenScript Custom Assay Services for VWCE GenScript Custom Superior Antibodies Services for VWCE
     GenScript Custom overexpressing Cell Line Services for VWCE CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in VWCE promoter
     Search Chromatin IP Primers for VWCE
     RT2 qPCR Primer Assay in human, mouse, rat VWCE
     Search GNC Networks for VWCE
     SABiosciences Custom PCR Arrays for VWCE
     Search Tocris compounds for VWCE
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Biologicals
     Novus Tissue Slides
     Search for Antibodies for VWCE at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for VWCE
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.
     Search LifeMap BioReagents cell lines for VWCE
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VWCE
     SwitchGear 3'UTR luciferase reporter plasmids for VWCE
     SwitchGear Promoter luciferase reporter plasmids for VWCE
     Search ThermoFisher Antibodies for VWCE
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VWCE
     inGenious Targeting Laboratory - Custom generated mouse model solutions for VWCE
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for VWCE
    Customized:
     lentivirus for stable overexpression of VWCE
     lentivirus expression plasmids for stable overexpression of VWCE
     adenovirus for overexpression of VWCE
     Search LSBio for Antibodies for VWCE
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      VWCE gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4