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Aliases for VWCE Gene

Aliases for VWCE Gene

  • Von Willebrand Factor C And EGF Domains 2 3
  • URG11 3 4 6
  • HBV X Protein Up-Regulated Gene 11 Protein 3 4
  • HBxAg Up-Regulated Gene 11 Protein 3 4
  • VWC1 3 6
  • Von Willebrand Factor C And EGF Domain-Containing Protein 3

External Ids for VWCE Gene

Summaries for VWCE Gene

GeneCards Summary for VWCE Gene

VWCE (Von Willebrand Factor C And EGF Domains) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is NPNT.

UniProtKB/Swiss-Prot for VWCE Gene

  • May be a regulatory element in the beta-catenin signaling pathway and a target for chemoprevention of hapatocellular carcinoma.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VWCE Gene

Genomics for VWCE Gene

Genomic Location for VWCE Gene

Start:
61,258,286 bp from pter
End:
61,295,424 bp from pter
Size:
37,139 bases
Orientation:
Minus strand

Genomic View for VWCE Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for VWCE Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VWCE Gene

Regulatory Elements for VWCE Gene

Proteins for VWCE Gene

  • Protein details for VWCE Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96DN2-VWCE_HUMAN
    Recommended name:
    von Willebrand factor C and EGF domain-containing protein
    Protein Accession:
    Q96DN2
    Secondary Accessions:
    • A5PKV0
    • Q7Z7L6
    • Q86WK8

    Protein attributes for VWCE Gene

    Size:
    955 amino acids
    Molecular mass:
    99915 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAO47606.1; Type=Frameshift; Positions=210, 232, 745, 761, 769, 837, 912; Evidence={ECO:0000305};

    Alternative splice isoforms for VWCE Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for VWCE Gene

Proteomics data for VWCE Gene at MOPED

Post-translational modifications for VWCE Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn462, Asn472, Ser879, and Ser885

Other Protein References for VWCE Gene

No data available for DME Specific Peptides for VWCE Gene

Domains for VWCE Gene

UniProtKB/Swiss-Prot:

VWCE_HUMAN
Domain:
  • Contains 4 EGF-like domains.:
    • Q96DN2
  • Contains 6 VWFC domains.:
    • Q96DN2
genes like me logo Genes that share domains with VWCE: view

No data available for Gene Families for VWCE Gene

Function for VWCE Gene

Molecular function for VWCE Gene

UniProtKB/Swiss-Prot Function: May be a regulatory element in the beta-catenin signaling pathway and a target for chemoprevention of hapatocellular carcinoma.
UniProtKB/Swiss-Prot Induction: By HBxAg.

Gene Ontology (GO) - Molecular Function for VWCE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with VWCE: view

Phenotypes for VWCE Gene

GenomeRNAi human phenotypes for VWCE:
genes like me logo Genes that share phenotypes with VWCE: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for VWCE Gene

Localization for VWCE Gene

Subcellular locations from UniProtKB/Swiss-Prot for VWCE Gene

Secreted. Note=According to PubMed:16496348 is localized in the cytoplasm. {ECO:0000269 PubMed:16496348}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for VWCE Gene COMPARTMENTS Subcellular localization image for VWCE gene
Compartment Confidence
cytosol 3
extracellular 3
nucleus 3
plasma membrane 3

Gene Ontology (GO) - Cellular Components for VWCE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with VWCE: view

Pathways for VWCE Gene

SuperPathways for VWCE Gene

No Data Available

Interacting Proteins for VWCE Gene

Gene Ontology (GO) - Biological Process for VWCE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008284 positive regulation of cell proliferation IEA --
GO:0009966 regulation of signal transduction IEA --
genes like me logo Genes that share ontologies with VWCE: view

No data available for Pathways by source for VWCE Gene

Transcripts for VWCE Gene

Unigene Clusters for VWCE Gene

Von Willebrand factor C and EGF domains:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for VWCE Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b · 15c ^ 16 ^ 17 ^ 18 ^ 19 ^ 20
SP1: -
SP2: - -
SP3:

Relevant External Links for VWCE Gene

GeneLoc Exon Structure for
VWCE
ECgene alternative splicing isoforms for
VWCE

Expression for VWCE Gene

mRNA expression in normal human tissues for VWCE Gene

mRNA differential expression in normal tissues according to GTEx for VWCE Gene

This gene is overexpressed in Liver (9.7) and Ovary (5.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for VWCE Gene

SOURCE GeneReport for Unigene cluster for VWCE Gene Hs.60640

mRNA Expression by UniProt/SwissProt for VWCE Gene

Q96DN2-VWCE_HUMAN
Tissue specificity: Expressed in liver.
genes like me logo Genes that share expressions with VWCE: view

Orthologs for VWCE Gene

This gene was present in the common ancestor of animals.

Orthologs for VWCE Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia VWCE 36
  • 98.6 (n)
  • 98.09 (a)
VWCE 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia VWCE 36
  • 84.51 (n)
  • 82.93 (a)
VWCE 37
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia VWCE 36
  • 84.58 (n)
  • 82.57 (a)
VWCE 37
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Vwce 36
  • 80.76 (n)
  • 79.29 (a)
Vwce 16
Vwce 37
  • 79 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia VWCE 37
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 56 (a)
OneToMany
-- 37
  • 30 (a)
OneToMany
-- 37
  • 29 (a)
OneToMany
-- 37
  • 75 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Vwce 36
  • 79.49 (n)
  • 77.8 (a)
chicken
(Gallus gallus)
Aves VWCE 37
  • 58 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia VWCE 37
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100488202 36
  • 58.35 (n)
  • 54.32 (a)
zebrafish
(Danio rerio)
Actinopterygii VWCE 37
  • 23 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea mua-3 37
  • 6 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 5 (a)
OneToMany
Species with no ortholog for VWCE:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for VWCE Gene

ENSEMBL:
Gene Tree for VWCE (if available)
TreeFam:
Gene Tree for VWCE (if available)

Paralogs for VWCE Gene

Paralogs for VWCE Gene

Pseudogenes.org Pseudogenes for VWCE Gene

genes like me logo Genes that share paralogs with VWCE: view

Variants for VWCE Gene

Sequence variations from dbSNP and Humsavar for VWCE Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs1048498 -- 61,258,506(-) CCCAA(A/G)AAGTG utr-variant-3-prime
rs1108769 -- 61,287,420(-) TGCCC(G/T)TTTGA intron-variant
rs1815842 -- 61,265,755(+) ATGAA(C/G)AATTT intron-variant
rs2001746 -- 61,266,053(-) ATTTT(A/T)TTTTT intron-variant
rs2014786 -- 61,265,721(+) GTCAT(C/T)CCGCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for VWCE Gene

Variant ID Type Subtype PubMed ID
nsv428259 CNV Gain+Loss 18775914
dgv390e1 CNV Complex 17122850
nsv832177 CNV Loss 17160897
nsv341 CNV Insertion 18451855
esv28446 CNV Loss 19812545
nsv509415 CNV Insertion 20534489
nsv8834 CNV Gain+Loss 18304495

Relevant External Links for VWCE Gene

HapMap Linkage Disequilibrium report
VWCE

Disorders for VWCE Gene

No disorders were found for VWCE Gene.

No data available for UniProtKB/Swiss-Prot for VWCE Gene

Publications for VWCE Gene

  1. Upregulated expression of a unique gene by hepatitis B x antigen promotes hepatocellular growth and tumorigenesis. (PMID: 12869306) Lian Z. … Feitelson M.A. (Neoplasia 2003) 2 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Enhanced cell survival of Hep3B cells by the hepatitis B x antigen effector, URG11, is associated with upregulation of beta-catenin. (PMID: 16496348) Lian Z. … Feitelson M.A. (Hepatology 2006) 3 4
  4. URG11 promotes gastric cancer growth and invasion by activation of beta-catenin signalling pathway. (PMID: 19413886) Du R. … Fan D. (J. Cell. Mol. Med. 2010) 3
  5. URG11 mediates hypoxia-induced epithelial-to-mesenchymal transition by modulation of E-cadherin and beta-catenin. (PMID: 19900406) Du R. … Fan D. (Biochem. Biophys. Res. Commun. 2010) 3

Products for VWCE Gene

Sources for VWCE Gene

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