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Aliases for VWCE Gene

Aliases for VWCE Gene

  • Von Willebrand Factor C And EGF Domains 2 3 5
  • HBV X Protein Up-Regulated Gene 11 Protein 3 4
  • HBxAg Up-Regulated Gene 11 Protein 3 4
  • URG11 3 4
  • Von Willebrand Factor C And EGF Domain-Containing Protein 3
  • VWC1 3

External Ids for VWCE Gene

Previous GeneCards Identifiers for VWCE Gene

  • GC11M060783
  • GC11M061025
  • GC11M057353

Summaries for VWCE Gene

GeneCards Summary for VWCE Gene

VWCE (Von Willebrand Factor C And EGF Domains) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is KCP.

UniProtKB/Swiss-Prot for VWCE Gene

  • May be a regulatory element in the beta-catenin signaling pathway and a target for chemoprevention of hapatocellular carcinoma.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VWCE Gene

Genomics for VWCE Gene

Regulatory Elements for VWCE Gene

Enhancers for VWCE Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G061267 0.9 ENCODE 12.3 +27.8 27801 0.2 CBX3 RB1 MLX ARID4B E2F7 ZNF48 RARA YY1 GATA2 SP5 VWCE DDB1 TKFC PGA5
GH11G061265 0.8 ENCODE 12.3 +29.9 29934 0.8 ELF3 FOXA2 MLX MAX CEBPG THRB ZSCAN9 RARA ZNF121 NCOR1 VWCE DDB1 TKFC PGA5
GH11G061254 0.8 ENCODE 11.5 +40.8 40821 0.2 HDGF CTCF PKNOX1 CBX3 RB1 WRNIP1 ARID4B RAD21 ZNF143 SMC3 VWCE DDB1 TKFC PGA5
GH11G061693 1.9 FANTOM5 Ensembl ENCODE dbSUPER 4.7 -402.5 -402501 8.5 PKNOX1 SIN3A ZBTB7B FOS DEK ZNF263 ZHX2 REST SMARCB1 ZNF592 MYRF DKFZP434K028 DAGLA SYT7 FTH1 CYB561A3 VWCE SDHAF2 DDB1 CPSF7
GH11G061256 0.2 ENCODE 11.5 +38.5 38501 0.2 VWCE DDB1 TKFC PGA5
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around VWCE on UCSC Golden Path with GeneCards custom track

Promoters for VWCE Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000040240 524 1001 ARID4B FEZF1 DMAP1 ZNF48 SLC30A9 GLIS2 SP5 MXD4 PPARG KAT8

Genomic Location for VWCE Gene

Chromosome:
11
Start:
61,258,286 bp from pter
End:
61,295,424 bp from pter
Size:
37,139 bases
Orientation:
Minus strand

Genomic View for VWCE Gene

Genes around VWCE on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
VWCE Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for VWCE Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VWCE Gene

Proteins for VWCE Gene

  • Protein details for VWCE Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96DN2-VWCE_HUMAN
    Recommended name:
    von Willebrand factor C and EGF domain-containing protein
    Protein Accession:
    Q96DN2
    Secondary Accessions:
    • A5PKV0
    • Q7Z7L6
    • Q86WK8

    Protein attributes for VWCE Gene

    Size:
    955 amino acids
    Molecular mass:
    99915 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAO47606.1; Type=Frameshift; Positions=210, 232, 745, 761, 769, 837, 912; Evidence={ECO:0000305};

    Alternative splice isoforms for VWCE Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for VWCE Gene

Post-translational modifications for VWCE Gene

  • Glycosylation at isoforms=462, isoforms=472, and isoforms=885
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for VWCE Gene

Domains & Families for VWCE Gene

Suggested Antigen Peptide Sequences for VWCE Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with VWCE: view

No data available for Gene Families and UniProtKB/Swiss-Prot for VWCE Gene

Function for VWCE Gene

Molecular function for VWCE Gene

UniProtKB/Swiss-Prot Function:
May be a regulatory element in the beta-catenin signaling pathway and a target for chemoprevention of hapatocellular carcinoma.
UniProtKB/Swiss-Prot Induction:
By HBxAg.

Gene Ontology (GO) - Molecular Function for VWCE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
genes like me logo Genes that share ontologies with VWCE: view
genes like me logo Genes that share phenotypes with VWCE: view

Animal Model Products

  • Taconic Biosciences Mouse Models for VWCE

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for VWCE Gene

Localization for VWCE Gene

Subcellular locations from UniProtKB/Swiss-Prot for VWCE Gene

Secreted. Note=According to PubMed:16496348 is localized in the cytoplasm. {ECO:0000269 PubMed:16496348}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for VWCE gene
Compartment Confidence
plasma membrane 4
extracellular 4
nucleus 2
cytosol 2

Gene Ontology (GO) - Cellular Components for VWCE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with VWCE: view

Pathways & Interactions for VWCE Gene

No Data Available

Interacting Proteins for VWCE Gene

Gene Ontology (GO) - Biological Process for VWCE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008284 positive regulation of cell proliferation IEA --
GO:0009966 regulation of signal transduction IEA --
genes like me logo Genes that share ontologies with VWCE: view

No data available for Pathways by source and SIGNOR curated interactions for VWCE Gene

Drugs & Compounds for VWCE Gene

No Compound Related Data Available

Transcripts for VWCE Gene

Unigene Clusters for VWCE Gene

Von Willebrand factor C and EGF domains:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for VWCE Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b · 15c ^ 16 ^ 17 ^ 18 ^ 19 ^ 20
SP1: -
SP2: - -
SP3:

Relevant External Links for VWCE Gene

GeneLoc Exon Structure for
VWCE
ECgene alternative splicing isoforms for
VWCE

Expression for VWCE Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for VWCE Gene

mRNA differential expression in normal tissues according to GTEx for VWCE Gene

This gene is overexpressed in Liver (x9.7) and Ovary (x5.1).

Protein differential expression in normal tissues from HIPED for VWCE Gene

This gene is overexpressed in Placenta (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for VWCE Gene



Protein tissue co-expression partners for VWCE Gene

NURSA nuclear receptor signaling pathways regulating expression of VWCE Gene:

VWCE

SOURCE GeneReport for Unigene cluster for VWCE Gene:

Hs.60640

mRNA Expression by UniProt/SwissProt for VWCE Gene:

Q96DN2-VWCE_HUMAN
Tissue specificity: Expressed in liver.
genes like me logo Genes that share expression patterns with VWCE: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for VWCE Gene

Orthologs for VWCE Gene

This gene was present in the common ancestor of animals.

Orthologs for VWCE Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia VWCE 34 35
  • 98.6 (n)
dog
(Canis familiaris)
Mammalia VWCE 34 35
  • 84.58 (n)
cow
(Bos Taurus)
Mammalia VWCE 34 35
  • 84.51 (n)
mouse
(Mus musculus)
Mammalia Vwce 34 16 35
  • 80.76 (n)
rat
(Rattus norvegicus)
Mammalia Vwce 34
  • 79.49 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 75 (a)
OneToMany
-- 35
  • 56 (a)
OneToMany
-- 35
  • 30 (a)
OneToMany
-- 35
  • 29 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia VWCE 35
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves VWCE 35
  • 58 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia VWCE 35
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100488202 34
  • 58.35 (n)
zebrafish
(Danio rerio)
Actinopterygii VWCE 35
  • 23 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea mua-3 35
  • 6 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 5 (a)
OneToMany
Species where no ortholog for VWCE was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for VWCE Gene

ENSEMBL:
Gene Tree for VWCE (if available)
TreeFam:
Gene Tree for VWCE (if available)

Paralogs for VWCE Gene

Paralogs for VWCE Gene

genes like me logo Genes that share paralogs with VWCE: view

Variants for VWCE Gene

Sequence variations from dbSNP and Humsavar for VWCE Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000005426 -- 61,294,270(+) GCGCC(A/C)CCCGG intron-variant
rs1000052842 -- 61,287,501(+) ACTGC(A/G)TGCAG intron-variant
rs1000282236 -- 61,261,452(+) AAATC(A/T)TCAAA intron-variant
rs1000291661 -- 61,269,169(+) CCTAA(A/G)GAGGA intron-variant
rs1000348749 -- 61,261,598(+) AAAAA(G/T)TAACC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for VWCE Gene

Variant ID Type Subtype PubMed ID
esv2759831 CNV gain+loss 17122850
esv28446 CNV loss 19812545
esv3344020 CNV duplication 20981092
esv3626577 CNV loss 21293372
nsv1070460 CNV deletion 25765185
nsv1143542 CNV deletion 24896259
nsv1148857 CNV duplication 26484159
nsv341 CNV insertion 18451855
nsv428259 CNV gain+loss 18775914
nsv509415 CNV insertion 20534489
nsv832177 CNV loss 17160897
nsv8834 CNV gain+loss 18304495

Variation tolerance for VWCE Gene

Residual Variation Intolerance Score: 32.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.00; 49.87% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for VWCE Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
VWCE

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VWCE Gene

Disorders for VWCE Gene

Relevant External Links for VWCE

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
VWCE

No disorders were found for VWCE Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for VWCE Gene

Publications for VWCE Gene

  1. Enhanced cell survival of Hep3B cells by the hepatitis B x antigen effector, URG11, is associated with upregulation of beta-catenin. (PMID: 16496348) Lian Z. … Feitelson M.A. (Hepatology 2006) 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. Upregulated expression of a unique gene by hepatitis B x antigen promotes hepatocellular growth and tumorigenesis. (PMID: 12869306) Lian Z. … Feitelson M.A. (Neoplasia 2003) 2 3 64
  4. Knockdown of Upregulated Gene 11 (URG11) Inhibits Proliferation, Invasion, and I^-Catenin Expression in Non-Small Cell Lung Cancer Cells. (PMID: 27458101) Liu Z.L. … Chen Y.J. (Oncol. Res. 2016) 3 64
  5. [Increased expression URG11 in hepatocellular carcinoma tissues promotes the growth of hepatocellular carcinoma cells]. (PMID: 26522362) Xie H. … Liu J. (Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2015) 3 64

Products for VWCE Gene

Sources for VWCE Gene

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