VWCE Gene
protein-coding GIFtS : 43
GCID: GC11 M061025
von Willebrand factor C and EGF domains
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Aliasesfor VWCE gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Von Willebrand Factor C And EGF Domains 1 2 HBxAg Up-Regulated Gene 11 Protein2 3 URG111 2 3 5 FLJ320091 VWC11 2 5 Von Willebrand Factor C And EGF Domain-Containing Protein2 HBV X Protein Up-Regulated Gene 11 Protein2 3
Export aliases for VWCE gene to outside databases Previous GC identifers: GC11M060783 GC11M057353
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Summariesfor VWCE gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section UniProtKB/Swiss-Prot: VWCE_HUMAN, Q96DN2 Function : May be a regulatory element in the beta-catenin signaling pathway and a target for chemoprevention ofhapatocellular carcinoma
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Genomic Viewsfor VWCE gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000011.9 NC_018922.1 NT_167190.1 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the VWCE gene promoter: Sp1 AML1a Tal-1 AP-4 AP-2gamma E47 CREB deltaCREB Pax-4a Other transcription factors Search SABiosciences Chromatin IP Primers for VWCE Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat VWCE
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 11q12.2 Ensembl cytogenetic band: 11q12.2 HGNC cytogenetic band: 11q12.2 VWCE Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 11 GeneLoc Exon Structure
GeneLoc location for GC11M061025: view genomic region
(about GC identifiers )
Start:
61,025,758 bp from pter
End:
61,062,896 bp from pter
Size:
37,139 bases
Orientation:
minus strand
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Proteinsfor VWCE gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: VWCE_HUMAN, Q96DN2 (See
protein sequence )Recommended Name: von Willebrand factor C and EGF domain-containing protein precursor Size : 955 amino acids; 99915 Da
Subcellular location : Secreted (Potential). Note=According to PubMed:16496348 is localized in the cytoplasm
Sequence caution : Sequence=AAO47606.1; Type=Frameshift; Positions=210, 232, 745, 761, 769, 837, 912;
Secondary accessions : A5PKV0 Q7Z7L6 Q86WK8Alternative splicing : 2 isoforms : Q96DN2-1 Q96DN2-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for VWCE: NX_Q96DN2 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q96DN2 VWCE Protein expression data from MOPED and PaxDb : About this image REFSEQ proteins: NP_689931.2 ENSEMBL proteins: ENSP00000301770 ENSP00000334186 ENSP00000442570 ENSP00000441565 Human Recombinant Protein Products for VWCE: Gene Ontology (GO): 1 cellular component term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005576 extracellular region
IEA --
VWCE for ontologies About GeneDecksing VWCE Antibody Products: Assay Products for VWCE:
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Protein
Domains / Familiesfor VWCE gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
VWCE for domains About GeneDecksing 5/6 InterPro domains/families (see all 6 ):
Graphical View of Domain Structure for InterPro Entry Q96DN2 ProtoNet protein and cluster: Q96DN2
3 Blocks protein families : IPB000152 Aspartic acid and asparagine hydroxylation site IPB001007 von Willebrand factor IPB001881 EGF-like calcium-binding UniProtKB/Swiss-Prot: VWCE_HUMAN, Q96DN2 Similarity : Contains 4 EGF-like domainsSimilarity : Contains 6 VWFC domains
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Functionfor VWCE gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory ,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase ,
shRNA from
OriGene ,
Sirion Biotech ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Sirion Biotech ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
Sirion Biotech ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Molecular Function: UniProtKB/Swiss-Prot Summary: VWCE_HUMAN, Q96DN2 Function : May be a regulatory element in the beta-catenin signaling pathway and a target for chemoprevention ofhapatocellular carcinoma Induction : By HBxAg
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005509 calcium ion binding
IEA --
VWCE for ontologies About GeneDecksing Phenotypes: 1 GenomeRNAi human phenotype for VWCE :Animal Models: Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for VWCE (see all 2 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for VWCEOriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: VWCE (NM_152718 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for VWCE Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat VWCE
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VWCE
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Pathways & Interactionsfor VWCE gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for VWCE
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Drugs & Compoundsfor VWCE gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for VWCE Search CenterWatch for drugs/clinical trials and news about VWCE
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Transcriptsfor VWCE gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
Sirion Biotech ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for VWCE gene: NM_152718.2 Unigene Cluster for VWCE:
Von Willebrand factor C and EGF domains Hs.60640 [show with all ESTs ] Unigene Representative Sequence: NM_152718 7 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000301770 ENST00000335613 (uc001nra.3 uc001nrb.3 ) ENST00000535710 ENST00000538438 ENST00000398808 ENST00000535599 ENST00000538579 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for VWCE (see all 2 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for VWCEOriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: VWCE (NM_152718 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for VWCE Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat VWCE
Additional cDNA sequence: AK056571.1 AK299583.1 AK302241.1 BC042143.1 BC052564.1 BC077719.1 BC142624.1
5 DOTS entries : DT.100778136 DT.207448
DT.207449 DT.100715608 DT.120754830 24/54 AceView cDNA sequences (see all 54 ):
H74100 BC052564 CB988642 BQ066320 BQ642831 AA328361 BC042143 BQ653752 BM694786 AK056571 NM_152718 BC077719 BE464430 AW015067 BI252025 BX283551 CB240652 CD637970 AW081236 CD637965 AY205235 BX371953 CD637969 BQ062827 GeneLoc Exon Structure 3 Alternative Splicing Database (ASD) splice patterns (SP) for VWCE About this scheme ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b · 15c ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 SP1 :                               -                 SP2 :                               -   -               SP3 :                                              
ECgene alternative splicing isoforms for VWCE
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Expression for VWCE gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section VWCE expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: CGTCTCTCTGAbout this image VWCE expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table
See VWCE Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for VWCE SOURCE GeneReport for Unigene cluster: Hs.60640 UniProtKB/Swiss-Prot: VWCE_HUMAN, Q96DN2 Tissue specificity : Expressed in liver SABiosciences Custom PCR Arrays for VWCE Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for VWCEBrowse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat VWCE QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat VWCE QIAGEN QuantiFast Probe-based Assays in human , mouse , rat VWCE In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VWCE
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Orthologsfor VWCE gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of animals.
Orthologs for VWCE gene from 3/15 species (see all 15 ) About this table
Organism
Taxonomic classification
Gene
Description
Human Similarity
Orthology Type
Details
lizard (Anolis carolinensis)
Reptilia
VWCE6
--
64(a)
1 ↔ 1
GL343235.1(711401-741544)
zebrafish (Danio rerio)
Actinopterygii
CABZ01075689.16
--
1 → many
22(4162619-4176901)
worm (Caenorhabditis elegans)
Secernentea
fbn-16
FiBrilliN homolog family member (fbn-1)
4(a)
1 → many
III(7625311-7640988)
ENSEMBL Gene Tree for VWCE (if available)TreeFam Gene Tree for VWCE (if available)
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Paralogsfor VWCE gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for VWCE gene CHRD 2 CHRDL1 2 CRIM1 2 CHRDL2 2
VWCE for paralogs About GeneDecksing 2 Pseudogenes.org Pseudogenes for VWCE PGOHUM00000260288 PGOHUM00000260289
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Genomic Variantsfor VWCE gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 11 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for VWCE (61025758 - 61062896 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 8 variations for VWCE 8 CNVs : 4748 65970 30557 85813 31826 3854 85814 34999
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing VWCE
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Disorders
/ Diseasesfor VWCE gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
VWCE for disorders About GeneDecksing
OMIM gene information: 611115
OMIM disorders : --5 diseases for VWCE : About MalaCards hepatitis b gastric cancer hepatitis hypoxia carcinoma Export disorders for VWCE gene to outside databases
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Publicationsfor VWCE gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for VWCE gene integrated from 9 sources : (articles sorted by number of sources associating them with VWCE) Utopia : connect your pdf to the dynamic world of online information
Enhanced cell survival of Hep3B cells by the hepatitis B x antigen effector, URG11, is associated with upregulation of beta-catenin. (PubMed id 16496348) 1 , 2 Lian Z....Feitelson M.A. (2006) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 1 , 2 Ota T.... Sugano S. (2004) Upregulated expression of a unique gene by hepatitis B x antigen promotes hepatocellular growth and tumorigenesis. (PubMed id 12869306) 1 , 3 Lian Z....Feitelson M.A. (2003) URG11 promotes gastric cancer growth and invasion by activation of beta-catenin signalling pathway. (PubMed id 19413886) 1 Du R....Fan D. (2010) URG11 mediates hypoxia-induced epithelial-to-mesenchy mal transition by modulation of E-cadherin and beta-catenin. (PubMed id 19900406) 1 Du R....Fan D. (2010) Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560) 1 Kimura K.... Sugano S. (2006) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 2 Gerhard D.S....Malek J. (2004) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 Strausberg R.L....Marra M.A. (2002) Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence. (PubMed id 7566098) 1 Adams M.D....White O. (1995)
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External Searches for VWCE gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing VWCE gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing VWCE gene
(According to HUGE )
About This Section --
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Specialized Databases showing VWCE gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for VWCE Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for VWCE gene: Search GeneIP for patents involving VWCE GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor VWCE gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 and Sirion Biotech , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript , LifeMap BioReagents , and Sirion Biotech , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences , In Situ Hybridization Assays from Advanced Cell Diagnostics , Animal models from inGenious Targeting Laboratory )About This Section
Browse OriGene Antibodies OriGene shRNA RFP for VWCE OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for VWCE OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for VWCE Browse OriGene Protein Over-expression Lysates Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for VWCE OriGene 3'-UTR Clone for VWCE OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for VWCE OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for VWCE Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for VWCE OriGene Custom Protein Services for VWCE OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat VWCE QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing VWCE QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat VWCE QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat VWCE QIAGEN QuantiFast Probe-based Assays in human , mouse , rat VWCE QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat VWCE
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VWCE Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VWCE
Search ThermoFisher Antibodies for VWCE
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat VWCE
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Aliases for VWCE
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Disorders / Diseases for VWCE
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Expression for VWCE
Function for VWCE
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