VWC2L Gene
protein-coding GIFtS: 38
GCID: GC02P215275
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von Willebrand factor C domain containing protein 2-like(Previous name: von Willebrand factor C domain-containing protein 2-like...)
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Aliases
for VWC2L gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Von Willebrand Factor C Domain Containing Protein 2-Like1 2 | | Von Willebrand Factor C Domain-Containing Protein 2-Like1 2 | | Brorin-Like1 | | Brorin-Like1 |
Export aliases for VWC2L gene to outside databasesPrevious GC identifers: GC02P214985 GC02P207132 |
Summaries
for VWC2L gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: VWC2L_HUMAN, B2RUY7Function: May play a role in neurogenesis (By similarity). May play a role in bone differentiation and matrixmineralization (By similarity)
|
Genomic Views
for VWC2L gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_005403.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the VWC2L gene promoter:
SRF Bach1 SRF (504 AA) RORalpha1 AREB6 MEF-2A Pax-3 Zic1 aMEF-2 Ik-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for VWC2L
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat VWC2L |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2q34-q35 Ensembl cytogenetic band: 2q34 HGNC cytogenetic band: 2q34-q35VWC2L Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02P215275: view genomic region
(about GC identifiers)
Start:
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215,275,789 bp from pter |
End:
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215,443,683 bp from pter |
Size:
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167,895 bases |
Orientation:
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plus strand |
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Proteins
for VWC2L gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: VWC2L_HUMAN, B2RUY7 (See
protein sequence)Recommended Name: von Willebrand factor C domain-containing protein 2-like precursor Size: 222 amino acids; 24570 Da
Subunit: Peripherally associated with AMPAR complex. AMPAR complex consists of an inner core made of 4 pore-formingGluA/GRIA proteins (GRIA1, GRIA2, GRIA3 and GRIA4) and 4 major auxiliary subunits arranged in a twofold symmetry. Oneof the two pairs of distinct binding sites is occupied either by CNIH2, CNIH3 or CACNG2, CACNG3. The other harborsCACNG2, CACNG3, CACNG4, CACNG8 or GSG1L. This inner core of AMPAR complex is complemented by outer core constituentsbinding directly to the GluA/GRIA proteins at sites distinct from the interaction sites of the inner coreconstituents. Outer core constituents include at least PRRT1, PRRT2, CKAMP44/SHISA9, FRRS1L and NRN1. The proteins ofthe inner and outer core serve as a platform for other, more peripherally associated AMPAR constituents, includingVWC2L. Alone or in combination, these auxiliary subunits control the gating and pharmacology of the AMPAR complex andprofoundly impact their biogenesis and protein processing (By similarity)
Subcellular location: Secreted (By similarity). Cell junction, synapse (By similarity)
Secondary accessions: A6NC69 B2RUW7 B7X8X1Alternative splicing: 2 isoforms: B2RUY7-1 B2RUY7-2 Explore the universe of human proteins at neXtProt for VWC2L: NX_B2RUY7
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_B2RUY7
VWC2L Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001073969.1
ENSEMBL proteins: ENSP00000308976 ENSP00000403779
Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
VWC2L for ontologies About GeneDecksing
VWC2L Antibody Products:
Assay Products for VWC2L: |
Protein
Domains /
Families
for VWC2L gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
VWC2L for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry B2RUY7ProtoNet protein and cluster: B2RUY7 UniProtKB/Swiss-Prot: VWC2L_HUMAN, B2RUY7Similarity: Contains 2 VWFC domains |
Function
for VWC2L gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: VWC2L_HUMAN, B2RUY7Function: May play a role in neurogenesis (By similarity). May play a role in bone differentiation and matrixmineralization (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for VWC2L (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for VWC2L
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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Synthesis Service for VWC2L | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VWC2L |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VWC2L |
1 GenomeRNAi human phenotype for VWC2L:
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Pathways & Interactions
for VWC2L gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for VWC2L
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0030514 | negative regulation of BMP signaling pathway |
IEA | -- | | GO:0045666 | positive regulation of neuron differentiation |
IEA | -- |
VWC2L for ontologies About GeneDecksing
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Drugs & Compounds
for VWC2L gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for VWC2L
Search CenterWatch for drugs/clinical trials and news about VWC2L
|
Transcripts
for VWC2L gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for VWC2L gene: NM_001080500.2 Unigene Cluster for VWC2L: Von Willebrand factor C domain containing protein 2-like Hs.534834 [show with all ESTs]Unigene Representative Sequence: NM_0010805003 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000312504(uc002vet.2) ENST00000427124(uc010zjl.1) ENST00000477752
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for VWC2L (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for VWC2L
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: VWC2L (NM_001080500) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for VWC2L | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VWC2L |
Additional cDNA sequence: AB374231.1 BC146903.1 BC146911.1 BC146931.1 BC146935.1 BC171841.1 EF552207.1 EU541473.1 1 DOTS entry: DT.120940757
GeneLoc Exon Structure
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Expression
for VWC2L gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| VWC2L expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTTAACACAA
About this image
See VWC2L Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.534834
SABiosciences Custom PCR Arrays for VWC2L
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for VWC2L
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat VWC2L | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat VWC2L | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat VWC2L | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VWC2L |
Orthologs
for VWC2L gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for VWC2L gene from 4/10 species (see all 10) About this table
ENSEMBL Gene Tree for VWC2L (if available)
TreeFam Gene Tree for VWC2L (if available) |
Paralogs
for VWC2L gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for VWC2L gene
- VWC22
1 SIMAP similar gene for VWC2L using alignment to 2 protein entries: VWC2L_HUMAN (see all proteins):VWC2
VWC2L for paralogs About GeneDecksing
|
Genomic Variants
for VWC2L gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for VWC2L (215275789 - 215443683 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for VWC2L
1 CNV: 39277 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing VWC2L |
|
Disorders
/ Diseases
for VWC2L gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
VWC2L for disorders About GeneDecksing
2  diseases for VWC2L: About MalaCardsconduct disorder neuronitis
Human Genome Epidemiology (HuGE) Navigator: VWC2L (3 documents)
Export disorders for VWC2L gene to outside databases
|
Publications
for VWC2L gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for VWC2L gene integrated from 9 sources:
(articles sorted by number of sources associating them with VWC2L) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Modulation of matrix mineralization by Vwc2-like prote in and its novel splicing isoforms. (PubMed id 22209847)1 Ohyama Y....Mochida Y. (2012)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- Evidence for genes on chromosome 2 contributing to al cohol dependence with conduct disorder and suicide attempts. (PubMed id 20468071)1 Dick D.M....Bierut L. (2010)
- A novel neural-specific BMP antagonist, Brorin-like, of the Chordin family. (PubMed id 19852960)2 Miwa H....Itoh N. (2009)
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W....Wilson R.K. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for VWC2L gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing VWC2L gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing VWC2L gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing VWC2L gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for VWC2L | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for VWC2L gene:
Search GeneIP for patents involving VWC2L
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for VWC2L gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for VWC2L | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for VWC2L | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for VWC2L | | | OriGene Protein Over-expression Lysate for VWC2L | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for VWC2L | | OriGene 3'-UTR Clone for VWC2L | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for VWC2L | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for VWC2L | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for VWC2L | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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 | | | VWC2L Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VWC2L |
|  |  |  | | | | Search ThermoFisher Antibodies for VWC2L |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VWC2L |
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