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Aliases for VWC2L Gene

Aliases for VWC2L Gene

  • Von Willebrand Factor C Domain Containing Protein 2-Like 2 3
  • Von Willebrand Factor C Domain-Containing Protein 2-Like 2 3
  • Brorin-Like 3 4

External Ids for VWC2L Gene

Previous GeneCards Identifiers for VWC2L Gene

  • GC02P214985
  • GC02P215275
  • GC02P207132

Summaries for VWC2L Gene

GeneCards Summary for VWC2L Gene

VWC2L (Von Willebrand Factor C Domain Containing Protein 2-Like) is a Protein Coding gene. An important paralog of this gene is VWC2.

UniProtKB/Swiss-Prot for VWC2L Gene

  • May play a role in neurogenesis. May play a role in bone differentiation and matrix mineralization.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VWC2L Gene

Genomics for VWC2L Gene

Regulatory Elements for VWC2L Gene

Genomic Location for VWC2L Gene

Start:
214,411,065 bp from pter
End:
214,578,959 bp from pter
Size:
167,895 bases
Orientation:
Plus strand

Genomic View for VWC2L Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for VWC2L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VWC2L Gene

Proteins for VWC2L Gene

  • Protein details for VWC2L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    B2RUY7-VWC2L_HUMAN
    Recommended name:
    von Willebrand factor C domain-containing protein 2-like
    Protein Accession:
    B2RUY7
    Secondary Accessions:
    • A6NC69
    • B2RUW7
    • B7X8X1

    Protein attributes for VWC2L Gene

    Size:
    222 amino acids
    Molecular mass:
    24570 Da
    Quaternary structure:
    • Peripherally associated with AMPAR complex. AMPAR complex consists of an inner core made of 4 pore-forming GluA/GRIA proteins (GRIA1, GRIA2, GRIA3 and GRIA4) and 4 major auxiliary subunits arranged in a twofold symmetry. One of the two pairs of distinct binding sites is occupied either by CNIH2, CNIH3 or CACNG2, CACNG3. The other harbors CACNG2, CACNG3, CACNG4, CACNG8 or GSG1L. This inner core of AMPAR complex is complemented by outer core constituents binding directly to the GluA/GRIA proteins at sites distinct from the interaction sites of the inner core constituents. Outer core constituents include at least PRRT1, PRRT2, CKAMP44/SHISA9, FRRS1L and NRN1. The proteins of the inner and outer core serve as a platform for other, more peripherally associated AMPAR constituents, including VWC2L. Alone or in combination, these auxiliary subunits control the gating and pharmacology of the AMPAR complex and profoundly impact their biogenesis and protein processing (By similarity).

    Alternative splice isoforms for VWC2L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for VWC2L Gene

Proteomics data for VWC2L Gene at MOPED

Post-translational modifications for VWC2L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for VWC2L Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for VWC2L Gene

Domains for VWC2L Gene

Protein Domains for VWC2L Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for VWC2L Gene

Graphical View of Domain Structure for InterPro Entry

B2RUY7

UniProtKB/Swiss-Prot:

VWC2L_HUMAN :
  • B2RUY7
Domain:
  • Contains 2 VWFC domains.
genes like me logo Genes that share domains with VWC2L: view

No data available for Gene Families for VWC2L Gene

Function for VWC2L Gene

Molecular function for VWC2L Gene

UniProtKB/Swiss-Prot Function: May play a role in neurogenesis. May play a role in bone differentiation and matrix mineralization.

Gene Ontology (GO) - Molecular Function for VWC2L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with VWC2L: view

Phenotypes for VWC2L Gene

GenomeRNAi human phenotypes for VWC2L:
genes like me logo Genes that share phenotypes with VWC2L: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for VWC2L Gene

Localization for VWC2L Gene

Subcellular locations from UniProtKB/Swiss-Prot for VWC2L Gene

Secreted. Cell junction, synapse.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for VWC2L Gene COMPARTMENTS Subcellular localization image for VWC2L gene
Compartment Confidence
extracellular 3

Gene Ontology (GO) - Cellular Components for VWC2L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IEA --
GO:0030054 cell junction IEA --
GO:0032281 alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex IEA --
GO:0045202 synapse IEA --
genes like me logo Genes that share ontologies with VWC2L: view

Pathways for VWC2L Gene

SuperPathways for VWC2L Gene

No Data Available

Interacting Proteins for VWC2L Gene

Gene Ontology (GO) - Biological Process for VWC2L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030514 negative regulation of BMP signaling pathway IEA --
GO:0045666 positive regulation of neuron differentiation IEA --
genes like me logo Genes that share ontologies with VWC2L: view

No data available for Pathways by source for VWC2L Gene

Transcripts for VWC2L Gene

mRNA/cDNA for VWC2L Gene

(8) Additional mRNA sequences :
(2) REFSEQ mRNAs :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for VWC2L Gene

Von Willebrand factor C domain containing protein 2-like:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for VWC2L

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for VWC2L

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for VWC2L Gene

No ASD Table

Relevant External Links for VWC2L Gene

GeneLoc Exon Structure for
VWC2L
ECgene alternative splicing isoforms for
VWC2L

Expression for VWC2L Gene

mRNA expression in normal human tissues for VWC2L Gene

mRNA differential expression in normal tissues according to GTEx for VWC2L Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (9.1), Brain - Hypothalamus (8.7), Brain - Anterior cingulate cortex (BA24) (7.2), Brain - Cortex (5.8), Brain - Hippocampus (5.4), and Brain - Substantia nigra (5.0).

SOURCE GeneReport for Unigene cluster for VWC2L Gene Hs.534834

genes like me logo Genes that share expressions with VWC2L: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein expression and mRNA Expression by UniProt/SwissProt for VWC2L Gene

Orthologs for VWC2L Gene

This gene was present in the common ancestor of chordates.

Orthologs for VWC2L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia VWC2L 35
  • 99.55 (n)
  • 100 (a)
VWC2L 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia VWC2L 35
  • 95.05 (n)
  • 99.55 (a)
VWC2L 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia VWC2L 35
  • 96.25 (n)
  • 98.65 (a)
VWC2L 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Vwc2l 35
  • 94.74 (n)
  • 98.65 (a)
Vwc2l 16
Vwc2l 36
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia VWC2L 36
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia VWC2L 36
  • 87 (a)
OneToOne
chicken
(Gallus gallus)
Aves VWC2L 35
  • 87.39 (n)
  • 95.5 (a)
VWC2L 36
  • 95 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia VWC2L 36
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia vwc2l 35
  • 79.28 (n)
  • 88.74 (a)
zebrafish
(Danio rerio)
Actinopterygii vwc2l 35
  • 72.82 (n)
  • 78.38 (a)
vwc2l 36
  • 79 (a)
OneToOne
Species with no ortholog for VWC2L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for VWC2L Gene

ENSEMBL:
Gene Tree for VWC2L (if available)
TreeFam:
Gene Tree for VWC2L (if available)

Paralogs for VWC2L Gene

Paralogs for VWC2L Gene

Selected SIMAP similar genes for VWC2L Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with VWC2L: view

Variants for VWC2L Gene

Sequence variations from dbSNP and Humsavar for VWC2L Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs2037254 -- 214,576,316(-) TATTT(C/T)CCCTG downstream-variant-500B
rs3046806 -- 214,575,054(+) aaaaa(-/AAA)GAGCC intron-variant
rs3924563 -- 214,414,880(-) AGAAA(A/G)CATAT intron-variant
rs3935486 -- 214,490,994(+) ATTCA(C/T)AGATA intron-variant
rs4129194 -- 214,460,167(-) tctca(G/T)gattt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for VWC2L Gene

Variant ID Type Subtype PubMed ID
esv2721442 CNV Deletion 23290073
nsv875830 CNV Gain 21882294
esv2721443 CNV Deletion 23290073
esv2721444 CNV Deletion 23290073
esv2721445 CNV Deletion 23290073

Relevant External Links for VWC2L Gene

HapMap Linkage Disequilibrium report
VWC2L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VWC2L Gene

Disorders for VWC2L Gene

Relevant External Links for VWC2L

Genetic Association Database (GAD)
VWC2L
Human Genome Epidemiology (HuGE) Navigator
VWC2L
genes like me logo Genes that share disorders with VWC2L: view

No data available for UniProtKB/Swiss-Prot for VWC2L Gene

Publications for VWC2L Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  2. Evidence for genes on chromosome 2 contributing to alcohol dependence with conduct disorder and suicide attempts. (PMID: 20468071) Dick D.M. … Bierut L. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010) 3 48
  3. Modulation of matrix mineralization by Vwc2-like protein and its novel splicing isoforms. (PMID: 22209847) Ohyama Y. … Mochida Y. (Biochem. Biophys. Res. Commun. 2012) 3
  4. Generalization of Variants Identified by Genome-Wide Association Studies for Electrocardiographic Traits in African Americans. (PMID: 23534349) Jeff J.M. … Crawford D.C. (Ann. Hum. Genet. 2013) 3
  5. Genetic associations of variants in genes encoding HIV-dependency factors required for HIV-1 infection. (PMID: 21083371) Chinn L.W. … O'Brien S.J. (J. Infect. Dis. 2010) 48

Products for VWC2L Gene

Sources for VWC2L Gene

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