Free for academic non-profit institutions. Other users need a Commercial license

Aliases for VWC2L Gene

Aliases for VWC2L Gene

  • Von Willebrand Factor C Domain Containing Protein 2 Like 2 3 5
  • Von Willebrand Factor C Domain-Containing Protein 2-Like 2 3
  • Brorin-Like 3 4

External Ids for VWC2L Gene

Previous GeneCards Identifiers for VWC2L Gene

  • GC02P214985
  • GC02P215275
  • GC02P207132

Summaries for VWC2L Gene

GeneCards Summary for VWC2L Gene

VWC2L (Von Willebrand Factor C Domain Containing Protein 2 Like) is a Protein Coding gene. An important paralog of this gene is VWC2.

UniProtKB/Swiss-Prot for VWC2L Gene

  • May play a role in neurogenesis. May play a role in bone differentiation and matrix mineralization.

Additional gene information for VWC2L Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VWC2L Gene

Genomics for VWC2L Gene

GeneHancer (GH) Regulatory Elements for VWC2L Gene

Promoters and enhancers for VWC2L Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I214411 Promoter 1.2 EPDnew 550.8 0.0 -30 0.1 ARID4B SIN3A ZNF48 SLC30A9 ZNF143 NFYC MXD4 MIER2 REST PPARG VWC2L GC02P214401 ENSG00000197585
GH02I214481 Enhancer 0.5 ENCODE 0.2 +70.3 70347 0.2 MEF2D PKNOX1 POLR2A ZNF83 TRIM28 VWC2L-IT1 VWC2L ENSG00000197585
GH02I214465 Enhancer 0.3 Ensembl 0.2 +54.6 54636 0.2 CEBPG VWC2L-IT1 VWC2L ENSG00000197585
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around VWC2L on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the VWC2L gene promoter:

Genomic Locations for VWC2L Gene

Genomic Locations for VWC2L Gene
167,973 bases
Plus strand

Genomic View for VWC2L Gene

Genes around VWC2L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
VWC2L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for VWC2L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VWC2L Gene

Proteins for VWC2L Gene

  • Protein details for VWC2L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    von Willebrand factor C domain-containing protein 2-like
    Protein Accession:
    Secondary Accessions:
    • A6NC69
    • B2RUW7
    • B7X8X1

    Protein attributes for VWC2L Gene

    222 amino acids
    Molecular mass:
    24570 Da
    Quaternary structure:
    • Peripherally associated with AMPAR complex. AMPAR complex consists of an inner core made of 4 pore-forming GluA/GRIA proteins (GRIA1, GRIA2, GRIA3 and GRIA4) and 4 major auxiliary subunits arranged in a twofold symmetry. One of the two pairs of distinct binding sites is occupied either by CNIH2, CNIH3 or CACNG2, CACNG3. The other harbors CACNG2, CACNG3, CACNG4, CACNG8 or GSG1L. This inner core of AMPAR complex is complemented by outer core constituents binding directly to the GluA/GRIA proteins at sites distinct from the interaction sites of the inner core constituents. Outer core constituents include at least PRRT1, PRRT2, CKAMP44/SHISA9, FRRS1L and NRN1. The proteins of the inner and outer core serve as a platform for other, more peripherally associated AMPAR constituents, including VWC2L. Alone or in combination, these auxiliary subunits control the gating and pharmacology of the AMPAR complex and profoundly impact their biogenesis and protein processing (By similarity).

    Alternative splice isoforms for VWC2L Gene


neXtProt entry for VWC2L Gene

Post-translational modifications for VWC2L Gene

No Post-translational modifications

Other Protein References for VWC2L Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for VWC2L Gene

Domains & Families for VWC2L Gene

Gene Families for VWC2L Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for VWC2L Gene


Suggested Antigen Peptide Sequences for VWC2L Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with VWC2L: view

No data available for UniProtKB/Swiss-Prot for VWC2L Gene

Function for VWC2L Gene

Molecular function for VWC2L Gene

UniProtKB/Swiss-Prot Function:
May play a role in neurogenesis. May play a role in bone differentiation and matrix mineralization.

Phenotypes From GWAS Catalog for VWC2L Gene

Gene Ontology (GO) - Molecular Function for VWC2L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 27107012
genes like me logo Genes that share ontologies with VWC2L: view
genes like me logo Genes that share phenotypes with VWC2L: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for VWC2L Gene

Localization for VWC2L Gene

Subcellular locations from UniProtKB/Swiss-Prot for VWC2L Gene

Secreted. Cell junction, synapse.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for VWC2L gene
Compartment Confidence
extracellular 4
plasma membrane 2

Gene Ontology (GO) - Cellular Components for VWC2L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IEA --
GO:0030054 cell junction IEA --
GO:0032281 AMPA glutamate receptor complex IEA --
GO:0045202 synapse IEA --
genes like me logo Genes that share ontologies with VWC2L: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for VWC2L Gene

Pathways & Interactions for VWC2L Gene

SuperPathways for VWC2L Gene

No Data Available

Gene Ontology (GO) - Biological Process for VWC2L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development IEA --
GO:0030514 negative regulation of BMP signaling pathway IEA --
GO:0045666 positive regulation of neuron differentiation IEA --
genes like me logo Genes that share ontologies with VWC2L: view

No data available for Pathways by source and SIGNOR curated interactions for VWC2L Gene

Drugs & Compounds for VWC2L Gene

No Compound Related Data Available

Transcripts for VWC2L Gene

mRNA/cDNA for VWC2L Gene

(2) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for VWC2L Gene

Von Willebrand factor C domain containing protein 2-like:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for VWC2L Gene

No ASD Table

Relevant External Links for VWC2L Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for VWC2L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for VWC2L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for VWC2L Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x9.1), Brain - Hypothalamus (x8.7), Brain - Anterior cingulate cortex (BA24) (x7.2), Brain - Cortex (x5.8), Brain - Hippocampus (x5.4), and Brain - Substantia nigra (x5.0).

NURSA nuclear receptor signaling pathways regulating expression of VWC2L Gene:


SOURCE GeneReport for Unigene cluster for VWC2L Gene:


Evidence on tissue expression from TISSUES for VWC2L Gene

  • Nervous system(4)
genes like me logo Genes that share expression patterns with VWC2L: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for VWC2L Gene

Orthologs for VWC2L Gene

This gene was present in the common ancestor of chordates.

Orthologs for VWC2L Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia VWC2L 33 34
  • 99.55 (n)
(Canis familiaris)
Mammalia VWC2L 33 34
  • 96.25 (n)
(Bos Taurus)
Mammalia VWC2L 33 34
  • 95.05 (n)
(Monodelphis domestica)
Mammalia VWC2L 34
  • 95 (a)
(Mus musculus)
Mammalia Vwc2l 33 16 34
  • 94.74 (n)
(Ornithorhynchus anatinus)
Mammalia VWC2L 34
  • 87 (a)
(Gallus gallus)
Aves VWC2L 33 34
  • 87.39 (n)
(Anolis carolinensis)
Reptilia VWC2L 34
  • 83 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia vwc2l 33
  • 79.28 (n)
(Danio rerio)
Actinopterygii vwc2l 33 34
  • 72.82 (n)
Species where no ortholog for VWC2L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for VWC2L Gene

Gene Tree for VWC2L (if available)
Gene Tree for VWC2L (if available)

Paralogs for VWC2L Gene

Paralogs for VWC2L Gene

(1) SIMAP similar genes for VWC2L Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with VWC2L: view

Variants for VWC2L Gene

Sequence variations from dbSNP and Humsavar for VWC2L Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000023534 -- 214,543,198(+) C/G intron_variant
rs1000024065 -- 214,540,618(+) C/T intron_variant
rs1000029180 -- 214,470,461(+) G/C intron_variant
rs1000039448 -- 214,419,642(+) C/G intron_variant
rs1000047112 -- 214,572,753(+) T/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for VWC2L Gene

Variant ID Type Subtype PubMed ID
esv2721442 CNV deletion 23290073
esv2721443 CNV deletion 23290073
esv2721444 CNV deletion 23290073
esv2721445 CNV deletion 23290073
esv3560966 CNV deletion 23714750
esv3575332 CNV gain 25503493
esv3594260 CNV loss 21293372
esv3594261 CNV loss 21293372
nsv1007833 CNV loss 25217958
nsv1123428 CNV deletion 24896259

Variation tolerance for VWC2L Gene

Residual Variation Intolerance Score: 64.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.63; 13.54% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for VWC2L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VWC2L Gene

Disorders for VWC2L Gene

Additional Disease Information for VWC2L

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for VWC2L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for VWC2L Gene

Publications for VWC2L Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  2. Evidence for genes on chromosome 2 contributing to alcohol dependence with conduct disorder and suicide attempts. (PMID: 20468071) Dick DM … Bierut L (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2010) 3 44 58
  3. Pooled-matrix protein interaction screens using Barcode Fusion Genetics. (PMID: 27107012) Yachie N … Roth FP (Molecular systems biology 2016) 3 58
  4. Generalization of variants identified by genome-wide association studies for electrocardiographic traits in African Americans. (PMID: 23534349) Jeff JM … Crawford DC (Annals of human genetics 2013) 3 58
  5. Modulation of matrix mineralization by Vwc2-like protein and its novel splicing isoforms. (PMID: 22209847) Ohyama Y … Mochida Y (Biochemical and biophysical research communications 2012) 3 58

Products for VWC2L Gene

Sources for VWC2L Gene

Loading form....