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Aliases for VWC2 Gene

Aliases for VWC2 Gene

  • Von Willebrand Factor C Domain Containing 2 2 3
  • Brorin 2 3 6
  • Von Willebrand Factor C Domain-Containing Protein 2 3 4
  • Brain-Specific Chordin-Like Protein 3 4
  • Brain-Specific Chordin-Like 2
  • PSST739 3
  • UNQ739 3

External Ids for VWC2 Gene

Summaries for VWC2 Gene

Entrez Gene Summary for VWC2 Gene

  • This gene encodes a secreted bone morphogenic protein antagonist. The encoded protein is possibly involved in neural function and development and may have a role in cell adhesion.[provided by RefSeq, Oct 2009]

GeneCards Summary for VWC2 Gene

VWC2 (Von Willebrand Factor C Domain Containing 2) is a Protein Coding gene. An important paralog of this gene is VWC2L.

UniProtKB/Swiss-Prot for VWC2 Gene

  • BMP antagonist which may play a role in neural development. Promotes cell adhesion (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VWC2 Gene

Genomics for VWC2 Gene

Regulatory Elements for VWC2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for VWC2 Gene

Start:
49,773,661 bp from pter
End:
49,921,951 bp from pter
Size:
148,291 bases
Orientation:
Plus strand

Genomic View for VWC2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for VWC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VWC2 Gene

Proteins for VWC2 Gene

  • Protein details for VWC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q2TAL6-VWC2_HUMAN
    Recommended name:
    Brorin
    Protein Accession:
    Q2TAL6
    Secondary Accessions:
    • Q6UXE2

    Protein attributes for VWC2 Gene

    Size:
    325 amino acids
    Molecular mass:
    35282 Da
    Quaternary structure:
    • Peripherally associated with AMPAR complex. AMPAR complex consists of an inner core made of 4 pore-forming GluA/GRIA proteins (GRIA1, GRIA2, GRIA3 and GRIA4) and 4 major auxiliary subunits arranged in a twofold symmetry. One of the two pairs of distinct binding sites is occupied either by CNIH2, CNIH3 or CACNG2, CACNG3. The other harbors CACNG2, CACNG3, CACNG4, CACNG8 or GSG1L. This inner core of AMPAR complex is complemented by outer core constituents binding directly to the GluA/GRIA proteins at sites distinct from the interaction sites of the inner core constituents. Outer core constituents include at least PRRT1, PRRT2, CKAMP44/SHISA9, FRRS1L and NRN1. The proteins of the inner and outer core serve as a platform for other, more peripherally associated AMPAR constituents, including VWC2. Alone or in combination, these auxiliary subunits control the gating and pharmacology of the AMPAR complex and profoundly impact their biogenesis and protein processing (By similarity).

neXtProt entry for VWC2 Gene

Proteomics data for VWC2 Gene at MOPED

Post-translational modifications for VWC2 Gene

No Post-translational modifications

Other Protein References for VWC2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for VWC2 Gene

Domains for VWC2 Gene

Protein Domains for VWC2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for VWC2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q2TAL6

UniProtKB/Swiss-Prot:

VWC2_HUMAN :
  • Q2TAL6
Domain:
  • Contains 2 VWFC domains.
genes like me logo Genes that share domains with VWC2: view

No data available for Gene Families for VWC2 Gene

Function for VWC2 Gene

Molecular function for VWC2 Gene

UniProtKB/Swiss-Prot Function: BMP antagonist which may play a role in neural development. Promotes cell adhesion (By similarity).

Gene Ontology (GO) - Molecular Function for VWC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with VWC2: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for VWC2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for VWC2 Gene

Localization for VWC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for VWC2 Gene

Secreted, extracellular space, extracellular matrix, basement membrane. Cell junction, synapse.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for VWC2 Gene COMPARTMENTS Subcellular localization image for VWC2 gene
Compartment Confidence
extracellular 3

Gene Ontology (GO) - Cellular Components for VWC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005604 basement membrane IEA --
GO:0005614 interstitial matrix IEA --
GO:0005615 extracellular space ISS 17400546
GO:0030054 cell junction IEA --
GO:0031012 extracellular matrix --
genes like me logo Genes that share ontologies with VWC2: view

Pathways for VWC2 Gene

SuperPathways for VWC2 Gene

No Data Available

Interacting Proteins for VWC2 Gene

Gene Ontology (GO) - Biological Process for VWC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010811 positive regulation of cell-substrate adhesion IEA --
GO:0030514 negative regulation of BMP signaling pathway ISS 17400546
GO:0045666 positive regulation of neuron differentiation ISS 17400546
genes like me logo Genes that share ontologies with VWC2: view

No data available for Pathways by source for VWC2 Gene

Transcripts for VWC2 Gene

mRNA/cDNA for VWC2 Gene

(1) REFSEQ mRNAs :
(5) Selected AceView cDNA sequences:
(3) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for VWC2 Gene

Von Willebrand factor C domain containing 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for VWC2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for VWC2 Gene

No ASD Table

Relevant External Links for VWC2 Gene

GeneLoc Exon Structure for
VWC2
ECgene alternative splicing isoforms for
VWC2

Expression for VWC2 Gene

mRNA expression in normal human tissues for VWC2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for VWC2 Gene

This gene is overexpressed in Heart - Left Ventricle (8.2), Ovary (6.4), Heart - Atrial Appendage (6.0), Brain - Cerebellar Hemisphere (5.5), and Brain - Cerebellum (4.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for VWC2 Gene

SOURCE GeneReport for Unigene cluster for VWC2 Gene Hs.629302

genes like me logo Genes that share expressions with VWC2: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for VWC2 Gene

Orthologs for VWC2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for VWC2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia VWC2 35
  • 99.9 (n)
  • 99.69 (a)
VWC2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia VWC2 35
  • 88 (n)
  • 92.31 (a)
VWC2 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia VWC2 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Vwc2 35
  • 87.86 (n)
  • 90.43 (a)
Vwc2 16
Vwc2 36
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia VWC2 36
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia VWC2 36
  • 78 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Vwc2 35
  • 87.45 (n)
  • 90.74 (a)
chicken
(Gallus gallus)
Aves VWC2 35
  • 78.33 (n)
  • 77.71 (a)
VWC2 36
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia VWC2 36
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia vwc2 35
  • 65.52 (n)
  • 67.08 (a)
zebrafish
(Danio rerio)
Actinopterygii vwc2 35
  • 74.03 (n)
  • 81.77 (a)
vwc2 36
  • 53 (a)
OneToOne
Species with no ortholog for VWC2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for VWC2 Gene

ENSEMBL:
Gene Tree for VWC2 (if available)
TreeFam:
Gene Tree for VWC2 (if available)

Paralogs for VWC2 Gene

Paralogs for VWC2 Gene

Selected SIMAP similar genes for VWC2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with VWC2: view

Variants for VWC2 Gene

Sequence variations from dbSNP and Humsavar for VWC2 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs475180 -- 49,852,355(-) GCCAG(G/T)CCTCT intron-variant
rs477954 -- 49,862,940(-) attga(G/T)acatc intron-variant
rs481076 -- 49,778,721(-) TGACA(A/C)ATCTC intron-variant
rs481343 -- 49,812,730(+) catct(C/G)ccata intron-variant
rs481551 -- 49,812,797(-) ATTAC(A/G)GGCAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for VWC2 Gene

Variant ID Type Subtype PubMed ID
nsv830996 CNV Gain 17160897

Relevant External Links for VWC2 Gene

HapMap Linkage Disequilibrium report
VWC2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VWC2 Gene

Disorders for VWC2 Gene

No disorders were found for VWC2 Gene.

No data available for UniProtKB/Swiss-Prot for VWC2 Gene

Publications for VWC2 Gene

  1. Brorin, a novel secreted bone morphogenetic protein antagonist, promotes neurogenesis in mouse neural precursor cells. (PMID: 17400546) Koike N. … Itoh N. (J. Biol. Chem. 2007) 2 3 4
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  4. von Willebrand factor type C domain-containing proteins regulate bone morphogenetic protein signaling through different recognition mechanisms. (PMID: 17483092) Zhang J.L. … Sebald W. (J. Biol. Chem. 2007) 3
  5. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 4

Products for VWC2 Gene

Sources for VWC2 Gene

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