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Aliases for VWA9 Gene

Aliases for VWA9 Gene

  • Von Willebrand Factor A Domain Containing 9 2 3 5
  • C15orf44 3 4
  • Chromosome 15 Open Reading Frame 44 2
  • UPF0464 Protein C15orf44 3

External Ids for VWA9 Gene

Previous HGNC Symbols for VWA9 Gene

  • C15orf44

Previous GeneCards Identifiers for VWA9 Gene

  • GC15M065872

Summaries for VWA9 Gene

GeneCards Summary for VWA9 Gene

VWA9 (Von Willebrand Factor A Domain Containing 9) is a Protein Coding gene. Among its related pathways are Gene Expression and RNA Polymerase II Transcription Initiation And Promoter Clearance.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VWA9 Gene

Genomics for VWA9 Gene

Regulatory Elements for VWA9 Gene

Promoters for VWA9 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around VWA9 on UCSC Golden Path with GeneCards custom track

Genomic Location for VWA9 Gene

Chromosome:
15
Start:
65,578,753 bp from pter
End:
65,611,289 bp from pter
Size:
32,537 bases
Orientation:
Minus strand

Genomic View for VWA9 Gene

Genes around VWA9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
VWA9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for VWA9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VWA9 Gene

Proteins for VWA9 Gene

  • Protein details for VWA9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96SY0-VWA9_HUMAN
    Recommended name:
    von Willebrand factor A domain-containing protein 9
    Protein Accession:
    Q96SY0
    Secondary Accessions:
    • B4DDI6
    • B4DVD5
    • Q49AH8
    • Q96HX5
    • Q9H0S5

    Protein attributes for VWA9 Gene

    Size:
    518 amino acids
    Molecular mass:
    57471 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for VWA9 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for VWA9 Gene

Proteomics data for VWA9 Gene at MOPED

Post-translational modifications for VWA9 Gene

  • Ubiquitination at Lys 195, Lys 418, and Lys 442
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for VWA9 Gene

Domains & Families for VWA9 Gene

Protein Domains for VWA9 Gene

Suggested Antigen Peptide Sequences for VWA9 Gene

Graphical View of Domain Structure for InterPro Entry

Q96SY0

UniProtKB/Swiss-Prot:

VWA9_HUMAN :
  • Contains 1 VWFA domain.
  • Belongs to the VWA9 family.
Domain:
  • Contains 1 VWFA domain.
Family:
  • Belongs to the VWA9 family.
genes like me logo Genes that share domains with VWA9: view

No data available for Gene Families for VWA9 Gene

Function for VWA9 Gene

genes like me logo Genes that share phenotypes with VWA9: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for VWA9 Gene

Localization for VWA9 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for VWA9 Gene COMPARTMENTS Subcellular localization image for VWA9 gene
Compartment Confidence
nucleus 3
cytosol 2
mitochondrion 2
plasma membrane 2
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for VWA9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with VWA9: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for VWA9 Gene

Pathways & Interactions for VWA9 Gene

genes like me logo Genes that share pathways with VWA9: view

Pathways by source for VWA9 Gene

Interacting Proteins for VWA9 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 8)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000326379%0d%0a9606.ENSP00000310260%0d%0a9606.ENSP00000327889%0d%0a9606.ENSP00000385722%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000323588%0d%0a
Selected Interacting proteins: Q96SY0-VWA9_HUMAN ENSP00000326379 for VWA9 Gene via I2D STRING

Gene Ontology (GO) - Biological Process for VWA9 Gene

None

No data available for SIGNOR curated interactions for VWA9 Gene

Drugs & Compounds for VWA9 Gene

No Compound Related Data Available

Transcripts for VWA9 Gene

Unigene Clusters for VWA9 Gene

Von Willebrand factor A domain containing 9:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for VWA9 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c · 3d · 3e ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14
SP1: - - - - - -
SP2: - -
SP3: - - - - -
SP4: -
SP5:
SP6:
SP7:
SP8:
SP9: - -

Relevant External Links for VWA9 Gene

GeneLoc Exon Structure for
VWA9
ECgene alternative splicing isoforms for
VWA9

Expression for VWA9 Gene

mRNA expression in normal human tissues for VWA9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for VWA9 Gene

This gene is overexpressed in Lymph node (27.2) and Breast (10.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for VWA9 Gene



SOURCE GeneReport for Unigene cluster for VWA9 Gene Hs.6686

mRNA Expression by UniProt/SwissProt for VWA9 Gene

Q96SY0-VWA9_HUMAN
Tissue specificity: Strongly expressed in numerous cancer cells compared with their non-cancerous counterparts (lung, prostate, colon, stomach and skin).
genes like me logo Genes that share expression patterns with VWA9: view

Protein tissue co-expression partners for VWA9 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for VWA9 Gene

Orthologs for VWA9 Gene

This gene was present in the common ancestor of animals.

Orthologs for VWA9 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia VWA9 35
  • 92.52 (n)
  • 97.44 (a)
VWA9 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia VWA9 35
  • 93.95 (n)
  • 97.86 (a)
VWA9 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Vwa9 35
  • 90.97 (n)
  • 97.85 (a)
Vwa9 16
Vwa9 36
  • 85 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia VWA9 35
  • 99.79 (n)
  • 99.79 (a)
VWA9 36
  • 87 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Vwa9 35
  • 90.75 (n)
  • 97.42 (a)
oppossum
(Monodelphis domestica)
Mammalia VWA9 36
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia VWA9 36
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves C10H15ORF44 35
  • 81.41 (n)
  • 93.8 (a)
VWA9 36
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia VWA9 36
  • 94 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia vwa9 35
  • 77.78 (n)
  • 87.82 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.3805 35
zebrafish
(Danio rerio)
Actinopterygii vwa9 35
  • 71.63 (n)
  • 79.34 (a)
wufi19c12 35
vwa9 36
  • 69 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007540 35
  • 49.79 (n)
  • 44.86 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG4785 35
  • 47.17 (n)
  • 37.97 (a)
CG4785 36
  • 27 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7256 36
  • 36 (a)
OneToOne
Species with no ortholog for VWA9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for VWA9 Gene

ENSEMBL:
Gene Tree for VWA9 (if available)
TreeFam:
Gene Tree for VWA9 (if available)

Paralogs for VWA9 Gene

No data available for Paralogs for VWA9 Gene

Variants for VWA9 Gene

Sequence variations from dbSNP and Humsavar for VWA9 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs9415 -- 65,593,493(-) ATACC(C/T)AACTT nc-transcript-variant, reference, synonymous-codon
rs10914 -- 65,579,082(+) GAGCC(C/T)CTGCC nc-transcript-variant, utr-variant-3-prime
rs11484 -- 65,579,360(-) AAATG(A/C)TTTAG nc-transcript-variant, utr-variant-3-prime
rs2174331 -- 65,593,097(-) TTTTT(A/T)AATTT intron-variant
rs2292114 -- 65,584,631(+) CAAAT(A/C)CCTTT intron-variant

Variation tolerance for VWA9 Gene

Residual Variation Intolerance Score: 27.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.91; 18.87% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for VWA9 Gene

HapMap Linkage Disequilibrium report
VWA9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for VWA9 Gene

Disorders for VWA9 Gene

Relevant External Links for VWA9

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
VWA9

No disorders were found for VWA9 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for VWA9 Gene

Publications for VWA9 Gene

  1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  4. The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells. (PMID: 23667531) Cox J.L. … Rizzino A. (PLoS ONE 2013) 3
  5. Interactome study suggests multiple cellular functions of hepatoma-derived growth factor (HDGF). (PMID: 21907836) Zhao J. … Yang P. (J Proteomics 2011) 3

Products for VWA9 Gene

Sources for VWA9 Gene

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