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Aliases for VWA7 Gene

Aliases for VWA7 Gene

  • Von Willebrand Factor A Domain Containing 7 2 3 5
  • Protein G7c 3 4
  • C6orf27 3 4
  • NG37 3 4
  • G7c 3 4
  • Von Willebrand Factor A Domain-Containing Protein 7 3
  • Chromosome 6 Open Reading Frame 27 2

External Ids for VWA7 Gene

Previous HGNC Symbols for VWA7 Gene

  • C6orf27

Previous GeneCards Identifiers for VWA7 Gene

  • GC06M031740
  • GC06M031766
  • GC06M031771

Summaries for VWA7 Gene

GeneCards Summary for VWA7 Gene

VWA7 (Von Willebrand Factor A Domain Containing 7) is a Protein Coding gene. Diseases associated with VWA7 include Orchitis and Testicular Disease.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VWA7 Gene

Genomics for VWA7 Gene

Regulatory Elements for VWA7 Gene

Enhancers for VWA7 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06F031829 0.2 ENCODE 22 -56.8 -56826 9.1 CREB3L1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 MEF2D GLIS1 ATF6B LSM2 LY6G5B DDX39B SKIV2L DXO GTF2H4 VARS LY6G6C CSNK2B
GH06F031771 1.2 Ensembl ENCODE 19.7 +4.7 4730 1.6 HDGF PKNOX1 MLX ARNT CREB3L1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 DXO GTF2H4 VWA7 LY6G5C VARS LSM2 ATF6B PRRC2A LY6G6C SAPCD1-AS1
GH06F031733 0.9 FANTOM5 ENCODE 12.1 +39.9 39877 8.5 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF263 SP3 LY6G5C MICA LSM2 EHMT2 LY6G5B DXO GTF2H4 VARS ABHD16A ATF6B
GH06F031805 0.7 ENCODE 11.7 -29.5 -29470 2.0 HDGF PKNOX1 ARNT CREB3L1 MLX WRNIP1 ARID4B SIN3A DMAP1 ZNF2 LSM2 DXO ATF6B GTF2H4 RPL3P2 VWA7 ENSG00000201555 SAPCD1 SAPCD1-AS1 MSH5
GH06F031710 0.5 Ensembl 11.7 +65.8 65831 2.2 YBX3 HDGF CTCF KLF1 ESRRA ETV1 KLF17 CDC5L RAD21 ZIC2 LY6G5C SKIV2L MSH5 MSH5-SAPCD1 SAPCD1 SAPCD1-AS1 VWA7 RNU6-850P ENSG00000201555 VARS
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around VWA7 on UCSC Golden Path with GeneCards custom track

Genomic Location for VWA7 Gene

Chromosome:
6
Start:
31,765,401 bp from pter
End:
31,777,331 bp from pter
Size:
11,931 bases
Orientation:
Minus strand

Genomic View for VWA7 Gene

Genes around VWA7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
VWA7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for VWA7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for VWA7 Gene

  • Protein details for VWA7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y334-VWA7_HUMAN
    Recommended name:
    von Willebrand factor A domain-containing protein 7
    Protein Accession:
    Q9Y334
    Secondary Accessions:
    • A2BEX8
    • A6NHR6
    • B0V041
    • Q5SSR5
    • Q96QC8
    • Q9UMP9

    Protein attributes for VWA7 Gene

    Size:
    891 amino acids
    Molecular mass:
    96060 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Found in the major hispocompatibility complex class III region. May be implicated in susceptibility to lung tumors.
    SequenceCaution:
    • Sequence=CAB52192.1; Type=Frameshift; Positions=553, 559, 783; Evidence={ECO:0000305};

    Alternative splice isoforms for VWA7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for VWA7 Gene

Post-translational modifications for VWA7 Gene

  • Glycosylation at Asn 55 and Asn 781
  • Modification sites at PhosphoSitePlus

Other Protein References for VWA7 Gene

No data available for DME Specific Peptides for VWA7 Gene

Domains & Families for VWA7 Gene

Protein Domains for VWA7 Gene

Suggested Antigen Peptide Sequences for VWA7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y334

UniProtKB/Swiss-Prot:

VWA7_HUMAN :
  • Contains 1 VWFA domain.
Domain:
  • Contains 1 VWFA domain.
genes like me logo Genes that share domains with VWA7: view

No data available for Gene Families for VWA7 Gene

Function for VWA7 Gene

Gene Ontology (GO) - Molecular Function for VWA7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with VWA7: view
genes like me logo Genes that share phenotypes with VWA7: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for VWA7 Gene

Localization for VWA7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for VWA7 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for VWA7 Gene COMPARTMENTS Subcellular localization image for VWA7 gene
Compartment Confidence
extracellular 2
plasma membrane 2
cytosol 1
lysosome 1
nucleus 1
vacuole 1

Gene Ontology (GO) - Cellular Components for VWA7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with VWA7: view

Pathways & Interactions for VWA7 Gene

SuperPathways for VWA7 Gene

No Data Available

Interacting Proteins for VWA7 Gene

Gene Ontology (GO) - Biological Process for VWA7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with VWA7: view

No data available for Pathways by source and SIGNOR curated interactions for VWA7 Gene

Transcripts for VWA7 Gene

Unigene Clusters for VWA7 Gene

Von Willebrand factor A domain containing 7:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for VWA7 Gene

No ASD Table

Relevant External Links for VWA7 Gene

GeneLoc Exon Structure for
VWA7
ECgene alternative splicing isoforms for
VWA7

Expression for VWA7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for VWA7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for VWA7 Gene

This gene is overexpressed in Pituitary (x10.2).

Protein differential expression in normal tissues from HIPED for VWA7 Gene

This gene is overexpressed in Platelet (44.3) and Heart (24.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for VWA7 Gene



Protein tissue co-expression partners for VWA7 Gene

NURSA nuclear receptor signaling pathways regulating expression of VWA7 Gene:

VWA7

SOURCE GeneReport for Unigene cluster for VWA7 Gene:

Hs.558553

mRNA Expression by UniProt/SwissProt for VWA7 Gene:

Q9Y334-VWA7_HUMAN
Tissue specificity: Expressed at low level in different cell lines.
genes like me logo Genes that share expression patterns with VWA7: view

Primer Products

Orthologs for VWA7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for VWA7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia VWA7 34 35
  • 99.25 (n)
cow
(Bos Taurus)
Mammalia VWA7 34 35
  • 86.23 (n)
dog
(Canis familiaris)
Mammalia VWA7 34 35
  • 85.68 (n)
mouse
(Mus musculus)
Mammalia Vwa7 34 16 35
  • 83.26 (n)
rat
(Rattus norvegicus)
Mammalia Vwa7 34
  • 82.45 (n)
oppossum
(Monodelphis domestica)
Mammalia VWA7 35
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia VWA7 35
  • 63 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia VWA7 35
  • 38 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia vwa7 34
  • 52.6 (n)
zebrafish
(Danio rerio)
Actinopterygii si:ch73-235d11.1 34
  • 50.15 (n)
VWA7 35
  • 30 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 22 (a)
OneToOne
Species where no ortholog for VWA7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for VWA7 Gene

ENSEMBL:
Gene Tree for VWA7 (if available)
TreeFam:
Gene Tree for VWA7 (if available)

Paralogs for VWA7 Gene

No data available for Paralogs for VWA7 Gene

Variants for VWA7 Gene

Sequence variations from dbSNP and Humsavar for VWA7 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs10581485 -- 31,774,175(+) AAAAA(-/A)GGATA intron-variant
rs111413333 -- 31,773,573(+) TTGGC(A/G)CGGTG intron-variant
rs111682977 -- 31,778,966(+) ACACA(C/G)CTTGG upstream-variant-2KB, splice-donor-variant
rs112038006 -- 31,768,335(+) CCAGG(C/G)GTGGT intron-variant
rs112112388 -- 31,775,783(+) TCCTA(C/T)AGGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for VWA7 Gene

Variant ID Type Subtype PubMed ID
dgv10403n54 CNV loss 21841781
dgv10404n54 CNV loss 21841781
esv2763547 CNV loss 21179565
esv3370799 CNV duplication 20981092
nsv1073969 CNV deletion 25765185
nsv1112900 CNV deletion 24896259
nsv1126749 CNV deletion 24896259
nsv601943 CNV loss 21841781

Variation tolerance for VWA7 Gene

Residual Variation Intolerance Score: 96.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.57; 72.30% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for VWA7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
VWA7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VWA7 Gene

Disorders for VWA7 Gene

MalaCards: The human disease database

(2) MalaCards diseases for VWA7 Gene - From: DISEASES

Disorder Aliases PubMed IDs
orchitis
  • inflammation of testis
testicular disease
  • disorder of testis
- elite association - COSMIC cancer census association via MalaCards
Search VWA7 in MalaCards View complete list of genes associated with diseases

Relevant External Links for VWA7

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
VWA7
genes like me logo Genes that share disorders with VWA7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for VWA7 Gene

Publications for VWA7 Gene

  1. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4 64
  2. Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse. (PMID: 14656967) Xie T. … Hood L. (Genome Res. 2003) 3 4 64
  3. G7c, a novel gene in the mouse and human major histocompatibility complex class III region, possibly controlling lung tumor susceptibility. (PMID: 10803853) Snoek M. … Campbell R.D. (Immunogenetics 2000) 3 4 64
  4. SR protein kinases promote splicing of nonconsensus introns. (PMID: 26167880) Lipp J.J. … Guthrie C. (Nat. Struct. Mol. Biol. 2015) 3 64
  5. Refining the association of MHC with multiple sclerosis in African Americans. (PMID: 20466734) McElroy J.P. … Gourraud P.A. (Hum. Mol. Genet. 2010) 3 64

Products for VWA7 Gene

Sources for VWA7 Gene

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