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Aliases for VWA7 Gene

Aliases for VWA7 Gene

  • Von Willebrand Factor A Domain Containing 7 2 3 5
  • Protein G7c 3 4
  • C6orf27 3 4
  • NG37 3 4
  • G7c 3 4
  • Chromosome 6 Open Reading Frame 27 2

External Ids for VWA7 Gene

Previous HGNC Symbols for VWA7 Gene

  • C6orf27

Previous GeneCards Identifiers for VWA7 Gene

  • GC06M031740

Summaries for VWA7 Gene

GeneCards Summary for VWA7 Gene

VWA7 (Von Willebrand Factor A Domain Containing 7) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VWA7 Gene

Genomics for VWA7 Gene

Regulatory Elements for VWA7 Gene

Enhancers for VWA7 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around VWA7 on UCSC Golden Path with GeneCards custom track

Promoters for VWA7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around VWA7 on UCSC Golden Path with GeneCards custom track

Genomic Location for VWA7 Gene

Chromosome:
6
Start:
31,765,401 bp from pter
End:
31,777,331 bp from pter
Size:
11,931 bases
Orientation:
Minus strand

Genomic View for VWA7 Gene

Genes around VWA7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
VWA7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for VWA7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for VWA7 Gene

  • Protein details for VWA7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y334-VWA7_HUMAN
    Recommended name:
    von Willebrand factor A domain-containing protein 7
    Protein Accession:
    Q9Y334
    Secondary Accessions:
    • A2BEX8
    • A6NHR6
    • B0V041
    • Q5SSR5
    • Q96QC8
    • Q9UMP9

    Protein attributes for VWA7 Gene

    Size:
    891 amino acids
    Molecular mass:
    96060 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Found in the major hispocompatibility complex class III region. May be implicated in susceptibility to lung tumors.
    SequenceCaution:
    • Sequence=CAB52192.1; Type=Frameshift; Positions=553, 559, 783; Evidence={ECO:0000305};

    Alternative splice isoforms for VWA7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for VWA7 Gene

Proteomics data for VWA7 Gene at MOPED

Post-translational modifications for VWA7 Gene

  • Glycosylation at Asn 55 and Asn 781
  • Modification sites at PhosphoSitePlus

Other Protein References for VWA7 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for VWA7 Gene

Domains & Families for VWA7 Gene

Protein Domains for VWA7 Gene

Suggested Antigen Peptide Sequences for VWA7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y334

UniProtKB/Swiss-Prot:

VWA7_HUMAN :
  • Contains 1 VWFA domain.
Domain:
  • Contains 1 VWFA domain.
genes like me logo Genes that share domains with VWA7: view

No data available for Gene Families for VWA7 Gene

Function for VWA7 Gene

Phenotypes for VWA7 Gene

genes like me logo Genes that share phenotypes with VWA7: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for VWA7 Gene

Localization for VWA7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for VWA7 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for VWA7 Gene COMPARTMENTS Subcellular localization image for VWA7 gene
Compartment Confidence
extracellular 2
plasma membrane 2
cytosol 1
lysosome 1
nucleus 1
vacuole 1

Gene Ontology (GO) - Cellular Components for VWA7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with VWA7: view

Pathways & Interactions for VWA7 Gene

SuperPathways for VWA7 Gene

No Data Available

Interacting Proteins for VWA7 Gene

Gene Ontology (GO) - Biological Process for VWA7 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for VWA7 Gene

Drugs & Compounds for VWA7 Gene

No Compound Related Data Available

Transcripts for VWA7 Gene

Unigene Clusters for VWA7 Gene

Von Willebrand factor A domain containing 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for VWA7 Gene

No ASD Table

Relevant External Links for VWA7 Gene

GeneLoc Exon Structure for
VWA7
ECgene alternative splicing isoforms for
VWA7

Expression for VWA7 Gene

mRNA expression in normal human tissues for VWA7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for VWA7 Gene

This gene is overexpressed in Pituitary (x10.2).

Protein differential expression in normal tissues from HIPED for VWA7 Gene

This gene is overexpressed in Platelet (44.3) and Heart (24.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for VWA7 Gene



SOURCE GeneReport for Unigene cluster for VWA7 Gene Hs.558553

mRNA Expression by UniProt/SwissProt for VWA7 Gene

Q9Y334-VWA7_HUMAN
Tissue specificity: Expressed at low level in different cell lines.
genes like me logo Genes that share expression patterns with VWA7: view

Protein tissue co-expression partners for VWA7 Gene

Primer Products

Orthologs for VWA7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for VWA7 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia VWA7 35
  • 86.23 (n)
  • 85.67 (a)
VWA7 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia VWA7 35
  • 85.68 (n)
  • 84.22 (a)
VWA7 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Vwa7 35
  • 83.26 (n)
  • 82.36 (a)
Vwa7 16
Vwa7 36
  • 82 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia VWA7 35
  • 99.25 (n)
  • 98.43 (a)
VWA7 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Vwa7 35
  • 82.45 (n)
  • 81.21 (a)
oppossum
(Monodelphis domestica)
Mammalia VWA7 36
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia VWA7 36
  • 63 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia VWA7 36
  • 38 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia vwa7 35
  • 52.6 (n)
  • 45.49 (a)
zebrafish
(Danio rerio)
Actinopterygii si:ch73-235d11.1 35
  • 50.15 (n)
  • 44.01 (a)
VWA7 36
  • 30 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 22 (a)
OneToOne
Species with no ortholog for VWA7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for VWA7 Gene

ENSEMBL:
Gene Tree for VWA7 (if available)
TreeFam:
Gene Tree for VWA7 (if available)

Paralogs for VWA7 Gene

No data available for Paralogs for VWA7 Gene

Variants for VWA7 Gene

Sequence variations from dbSNP and Humsavar for VWA7 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs17207531 - 31,776,061(+) CCAGG(A/C/T)GCGCG nc-transcript-variant, reference, missense
rs11966331 - 31,769,058(+) CGTCT(A/C/G/T)GAATG nc-transcript-variant, reference, missense
VAR_056886 -
VAR_056887 -
VAR_056888 -

Variation tolerance for VWA7 Gene

Residual Variation Intolerance Score: 96.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.57; 72.30% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for VWA7 Gene

Disorders for VWA7 Gene

Relevant External Links for VWA7

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
VWA7

No disorders were found for VWA7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for VWA7 Gene

Publications for VWA7 Gene

  1. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4 67
  2. SR protein kinases promote splicing of nonconsensus introns. (PMID: 26167880) Lipp J.J. … Guthrie C. (Nat. Struct. Mol. Biol. 2015) 3
  3. Refining the association of MHC with multiple sclerosis in African Americans. (PMID: 20466734) McElroy J.P. … Gourraud P.A. (Hum. Mol. Genet. 2010) 3
  4. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PMID: 21145461) Bennett E.J. … Harper J.W. (Cell 2010) 3
  5. Several loci in the HLA class III region are associated with T1D risk after adjusting for DRB1-DQB1. (PMID: 19143814) Valdes A.M. … Thomson G. (Diabetes Obes Metab 2009) 3

Products for VWA7 Gene

Sources for VWA7 Gene

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