VWA7 Gene
protein-coding GIFtS: 38
GCID: GC06M031740
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von Willebrand factor A domain containing 7(Previous name: chromosome 6 open reading frame 27 )
(Previous symbol: C6orf27)
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Aliases
for VWA7 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Von Willebrand Factor A Domain Containing 71 2 | | Protein G7c2 3 | | C6orf271 2 3 5 | | G7C3 5 | | NG371 2 3 | | Chromosome 6 Open Reading Frame 271 | | G7c1 2 | | Von Willebrand Factor A Domain-Containing Protein 72 |
Export aliases for VWA7 gene to outside databases |
Summaries
for VWA7 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for VWA7 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000006.11 NC_018917.1 NT_007592.15 NT_113891.2 NT_167244.1 NT_167245.1 NT_167247.1 NT_167249.1
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for VWA7
Other transcription factors
Search SABiosciences Chromatin IP Primers for VWA7
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat VWA7 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6p21.33 Ensembl cytogenetic band: 6p21.33 HGNC cytogenetic band: 6p21VWA7 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06M031740: view genomic region
(about GC identifiers)
Start:
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31,733,367 bp from pter |
End:
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31,745,108 bp from pter |
Size:
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11,742 bases |
Orientation:
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minus strand |
5 alternative locations:
| Chr6-,ALT_REF_LOCI_5 31,724,491-31,736,228 | Chr6-,ALT_REF_LOCI_2 31,720,750-31,771,663 | Chr6-,ALT_REF_LOCI_3 31,715,552-31,738,331 | | Chr6-,ALT_REF_LOCI_1 31,744,721-31,764,761 | Chr6-,ALT_REF_LOCI_7 31,653,649-31,665,385 |
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Proteins
for VWA7 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: VWA7_HUMAN, Q9Y334 (See
protein sequence)Recommended Name: von Willebrand factor A domain-containing protein 7 precursor Size: 891 amino acids; 96060 Da
Subcellular location: Secreted (Potential)
Miscellaneous: Found in the major hispocompatibility complex class III region. May be implicated in susceptibility tolung tumors
Sequence caution: Sequence=CAB52192.1; Type=Frameshift; Positions=553, 559, 783;
Secondary accessions: A2BEX8 A6NHR6 B0V041 Q5SSR5 Q96QC8 Q9UMP9Alternative splicing: 2 isoforms: Q9Y334-1 Q9Y334-2 (Ref.1 (AAD21820) sequence is in conflict in position: 837:H->Y)Explore the universe of human proteins at neXtProt for VWA7: NX_Q9Y334
VWA7 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_079534.2
ENSEMBL proteins: ENSP00000364840 ENSP00000364838 ENSP00000390554
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005575 | cellular_component |
ND | -- | | GO:0005576 | extracellular region |
IEA | -- |
VWA7 for ontologies About GeneDecksing
VWA7 Antibody Products:
Assay Products for VWA7: |
Protein
Domains /
Families
for VWA7 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
VWA7 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9Y334ProtoNet protein and cluster: Q9Y334 1 Blocks protein family: IPB002035 Von Willebrand factor type A domain signature
UniProtKB/Swiss-Prot: VWA7_HUMAN, Q9Y334Similarity: Contains 1 VWFA domain |
Function
for VWA7 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for VWA7 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for VWA7
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript Custom all cDNA clones Services for VWA7 | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for VWA7 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VWA7 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VWA7 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003674 | molecular_function |
ND | -- |
VWA7 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for VWA7:
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Pathways & Interactions
for VWA7 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for VWA7
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008150 | biological_process |
ND | -- |
VWA7 for ontologies About GeneDecksing
|
Drugs & Compounds
for VWA7 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for VWA7
Search CenterWatch for drugs/clinical trials and news about VWA7
|
Transcripts
for VWA7 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for VWA7 gene: NM_025258.2 Unigene Cluster for VWA7: Von Willebrand factor A domain containing 7 Hs.558553 [show with all ESTs]Unigene Representative Sequence: NM_0252587 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000375688 ENST00000486423 ENST00000467576 ENST00000487013 ENST00000497645
ENST00000375686(uc011dog.2 uc003nxd.2) ENST00000447450(uc011doh.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for VWA7 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for VWA7
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript Custom all cDNA clones Services for VWA7 | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for VWA7 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VWA7 |
Additional cDNA sequence: AJ245418.1 AK304058.1 AK304266.1 BC114625.1 3 DOTS entries: DT.40217088 DT.91785732 DT.100016688 20 AceView cDNA sequences: NM_025258 AA069495 BI711260 BI770580 AJ245418 BV181047 BV183539 BI711669 AK098390 BQ723157 AA133560 CK820534 BF855921 CD632613 CD632614 BF855920 CD632616 CD632615 AA757711 AA069267
GeneLoc Exon Structure
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Expression
for VWA7 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| VWA7 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTTTCCTCCG
About this image
See VWA7 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for VWA7
SOURCE GeneReport for Unigene cluster: Hs.558553
UniProtKB/Swiss-Prot: VWA7_HUMAN, Q9Y334Tissue specificity: Expressed at low level in different cell lines
SABiosciences Custom PCR Arrays for VWA7
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for VWA7
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat VWA7 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat VWA7 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat VWA7 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VWA7 |
Orthologs
for VWA7 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for VWA7 gene from 3/11 species (see all 11) About this table
ENSEMBL Gene Tree for VWA7 (if available)
TreeFam Gene Tree for VWA7 (if available) |
Paralogs
for VWA7 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for VWA7 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 6 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for VWA7 (31733367 - 31745108 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for VWA7: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing VWA7 |
|
Disorders
/ Diseases
for VWA7 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
VWA7 for disorders About GeneDecksing
OMIM gene information: 609693
OMIM disorders: --
2  diseases for VWA7: About MalaCardssystemic lupus erythematosus lupus erythematosus
Export disorders for VWA7 gene to outside databases
|
Publications
for VWA7 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for VWA7 gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with VWA7) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
- Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse. (PubMed id 14656967)1, 2 Xie T.... Hood L. (2003)
- G7c, a novel gene in the mouse and human major histocompatibility complex class III region, possibly controlling lung tumor susceptibility. (PubMed id 10803853)1, 2 Snoek M.... Campbell R.D. (2000)
- Refining the association of MHC with multiple scleros is in African Americans. (PubMed id 20466734)1 McElroy J.P....Gourraud P.A. (2010)
- Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)
- High-density SNP screening of the major histocompatib ility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PubMed id 19851445)1 Barcellos L.F....Criswell L.A. (2009)
- Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer's disease. (PubMed id 19204726)1 Chapuis J....Lambert J.C. (2009)
- Several loci in the HLA class III region are associated with T1D risk after adjusting for DRB1-DQB1. (PubMed id 19143814)1 Valdes A.M. and Thomson G. (2009)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- G7c in the lung tumor susceptibility (Lts) region of the Mhc class III region encodes a von Willebrand factor type A domain protein. (PubMed id 11261934)1 KumA!novics A. and Lindahl K.F. (2001)
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External Searches for VWA7 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing VWA7 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing VWA7 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing VWA7 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for VWA7 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for VWA7 gene:
Search GeneIP for patents involving VWA7
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for VWA7 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for VWA7 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for VWA7 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for VWA7 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for VWA7 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for VWA7 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for VWA7 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat VWA7 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing VWA7 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat VWA7 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat VWA7 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat VWA7 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat VWA7 |
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| | | | Search Tocris compounds for VWA7 |
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 | | | VWA7 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VWA7 |
|  |  |  | | | | ThermoFisher Antibody for VWA7 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VWA7 |
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