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Aliases for VWA3B Gene

Aliases for VWA3B Gene

  • Von Willebrand Factor A Domain Containing 3B 2 3

External Ids for VWA3B Gene

Summaries for VWA3B Gene

GeneCards Summary for VWA3B Gene

VWA3B (Von Willebrand Factor A Domain Containing 3B) is a Protein Coding gene. An important paralog of this gene is VWA3A.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VWA3B Gene

Genomics for VWA3B Gene

Genomic Location for VWA3B Gene

Start:
98,087,116 bp from pter
End:
98,313,299 bp from pter
Size:
226,184 bases
Orientation:
Plus strand

Genomic View for VWA3B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for VWA3B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VWA3B Gene

Regulatory Elements for VWA3B Gene

Proteins for VWA3B Gene

  • Protein details for VWA3B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q502W6-VWA3B_HUMAN
    Recommended name:
    von Willebrand factor A domain-containing protein 3B
    Protein Accession:
    Q502W6
    Secondary Accessions:
    • B9EK71
    • Q86T73
    • Q8N2D0
    • Q8N770
    • Q8NA79
    • Q8ND63
    • Q8ND65
    • Q8WW02

    Protein attributes for VWA3B Gene

    Size:
    1294 amino acids
    Molecular mass:
    145748 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC04047.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAD89964.1; Type=Frameshift; Positions=1071, 1087, 1110, 1147, 1153, 1195, 1207; Evidence={ECO:0000305};

    Alternative splice isoforms for VWA3B Gene

neXtProt entry for VWA3B Gene

Proteomics data for VWA3B Gene at MOPED

Post-translational modifications for VWA3B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for VWA3B Gene

Domains for VWA3B Gene

Protein Domains for VWA3B Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

VWA3B_HUMAN
Domain:
  • Contains 1 VWFA domain.:
    • Q502W6
genes like me logo Genes that share domains with VWA3B: view

No data available for Gene Families for VWA3B Gene

Function for VWA3B Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for VWA3B Gene

Localization for VWA3B Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for VWA3B Gene COMPARTMENTS Subcellular localization image for VWA3B gene
Compartment Confidence
nucleus 2
plasma membrane 2
cytosol 1
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for VWA3B Gene

Pathways for VWA3B Gene

SuperPathways for VWA3B Gene

No Data Available

Interacting Proteins for VWA3B Gene

Gene Ontology (GO) - Biological Process for VWA3B Gene

None

No data available for Pathways by source for VWA3B Gene

Transcripts for VWA3B Gene

Unigene Clusters for VWA3B Gene

Von Willebrand factor A domain containing 3B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for VWA3B Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^
SP1: - - - - -
SP2: - - - -
SP3: -
SP4: - -
SP5:

ExUns: 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29a · 29b
SP1:
SP2: -
SP3: -
SP4: -
SP5:

Relevant External Links for VWA3B Gene

GeneLoc Exon Structure for
VWA3B
ECgene alternative splicing isoforms for
VWA3B

Expression for VWA3B Gene

mRNA expression in normal human tissues for VWA3B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for VWA3B Gene

This gene is overexpressed in Testis (34.6).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for VWA3B Gene

SOURCE GeneReport for Unigene cluster for VWA3B Gene Hs.269977

genes like me logo Genes that share expressions with VWA3B: view

Orthologs for VWA3B Gene

This gene was present in the common ancestor of chordates.

Orthologs for VWA3B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia VWA3B 36
  • 99.2 (n)
  • 98.76 (a)
VWA3B 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia VWA3B 36
  • 84.17 (n)
  • 78.48 (a)
VWA3B 37
  • 72 (a)
OneToOne
dog
(Canis familiaris)
Mammalia VWA3B 36
  • 85.85 (n)
  • 80.95 (a)
VWA3B 37
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Vwa3b 36
  • 79.02 (n)
  • 72.75 (a)
Vwa3b 16
Vwa3b 37
  • 71 (a)
OneToMany
Vwa3b 37
  • 64 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia VWA3B 37
  • 45 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia VWA3B 37
  • 49 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Vwa3b 36
  • 78.37 (n)
  • 72.19 (a)
chicken
(Gallus gallus)
Aves VWA3B 36
  • 62.25 (n)
  • 54.11 (a)
VWA3B 37
  • 44 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia VWA3B 37
  • 47 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia vwa3b 36
  • 57.38 (n)
  • 47.98 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 40 (a)
OneToOne
Species with no ortholog for VWA3B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for VWA3B Gene

ENSEMBL:
Gene Tree for VWA3B (if available)
TreeFam:
Gene Tree for VWA3B (if available)

Paralogs for VWA3B Gene

Paralogs for VWA3B Gene

Selected SIMAP similar genes for VWA3B Gene using alignment to 10 proteins:

genes like me logo Genes that share paralogs with VWA3B: view

Variants for VWA3B Gene

Sequence variations from dbSNP and Humsavar for VWA3B Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs213170 -- 98,086,532(-) CAGGG(A/C)GCTGC upstream-variant-2KB
rs298914 -- 98,094,875(-) ggaca(A/G)tctct intron-variant
rs298915 -- 98,094,076(-) cacaa(C/T)agcca intron-variant
rs298916 -- 98,093,780(-) aagat(A/G)ttagt intron-variant
rs298917 -- 98,093,221(-) AGCCC(A/G)TGCAG synonymous-codon, reference, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for VWA3B Gene

Variant ID Type Subtype PubMed ID
dgv222n21 CNV Gain 19592680
nsv518056 CNV Gain 19592680
nsv834309 CNV Gain 17160897
nsv527817 CNV Loss 19592680
esv2720429 CNV Deletion 23290073
esv2672637 CNV Deletion 23128226
nsv818075 CNV Loss 17921354
nsv517669 CNV Loss 19592680
nsv437289 CNV Loss 16327808
esv2674476 CNV Deletion 23128226
esv24326 CNV Loss 19812545
nsv10105 CNV Loss 18304495
nsv438363 CNV Loss 16468122
esv6339 CNV Gain 19470904

Relevant External Links for VWA3B Gene

HapMap Linkage Disequilibrium report
VWA3B
Human Gene Mutation Database (HGMD)
VWA3B

Disorders for VWA3B Gene

Relevant External Links for VWA3B

Genetic Association Database (GAD)
VWA3B
Human Genome Epidemiology (HuGE) Navigator
VWA3B
genes like me logo Genes that share disorders with VWA3B: view

No data available for UniProtKB/Swiss-Prot for VWA3B Gene

Publications for VWA3B Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 49
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4
  5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 4

Products for VWA3B Gene

Sources for VWA3B Gene

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