Aliases for VWA3A Gene
External Ids for VWA3A Gene
- HGNC: 27088
- Entrez Gene: 146177
- Ensembl: ENSG00000175267
- UniProtKB: A6NCI4
Previous GeneCards Identifiers for VWA3A Gene
- GC16P022015
- GC16P020349
Summaries for VWA3A Gene
GeneCards Summary for VWA3A Gene
VWA3A (Von Willebrand Factor A Domain Containing 3A) is a Protein Coding gene. An important paralog of this gene is VWA3B.
No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VWA3A Gene
Genomics for VWA3A Gene
Regulatory Elements for VWA3A Gene
Enhancers for VWA3A Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around VWA3A on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for VWA3A Gene
- Chromosome:
- 16
- Start:
- 22,091,914 bp from pter
- End:
- 22,156,966 bp from pter
- Size:
- 65,053 bases
- Orientation:
- Plus strand
Genomic View for VWA3A Gene
Genes around VWA3A on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 16p12.2 by Ensembl
- 16p12.2 by Entrez Gene
- 16p12.2 by HGNC
VWA3A Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for VWA3A Gene
Proteins for VWA3A Gene
-
Protein details for VWA3A Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- A6NCI4-VWA3A_HUMAN
- Recommended name:
- von Willebrand factor A domain-containing protein 3A
- Protein Accession:
- A6NCI4
- A4QMU8
- A6NNC0
- Q6UTX4
- Q6ZQZ9
- Q8IUY6
- Q8N9W1
Protein attributes for VWA3A Gene
- Size:
- 1184 amino acids
- Molecular mass:
- 134020 Da
- Quaternary structure:
- No Data Available
Protein Expression for VWA3A Gene
Post-translational modifications for VWA3A Gene
Other Protein References for VWA3A Gene
Antibody Products
- Novus Biologicals Antibodies for VWA3A
-
Cloud-Clone Corp. Antibodies for VWA3A
- Invitrogen Antibodies for VWA3A
- Search GeneTex for Antibodies for VWA3A
Protein Products
-
OriGene Purified Proteins for VWA3A
- Search Origene for MassSpec and Protein Over-expression Lysates for VWA3A
- Origene Custom Protein Services for VWA3A
- Novus Biologicals proteins for VWA3A
-
Cloud-Clone Corp. Proteins for VWA3A
- Search GeneTex for Proteins for VWA3A
Assay Products
-
Cloud-Clone Corp Assay Kits for VWA3A
No data available for DME Specific Peptides for VWA3A Gene
Domains & Families for VWA3A Gene
Suggested Antigen Peptide Sequences for VWA3A Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for Gene Families and UniProtKB/Swiss-Prot for VWA3A Gene
Function for VWA3A Gene
Phenotypes for VWA3A Gene
- GenomeRNAi human phenotypes for VWA3A:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for VWA3A
-
-
ViGene Biosciences lentiviral particle packaged cDNA for VWA3A gene
-
ViGene Biosciences ready-to-package AAV shRNAs for VWA3A gene
- Search ViGene Biosciences for VWA3A
CRISPR Products
-
OriGene CRISPR knockouts for VWA3A
-
Santa Cruz Biotechnology (SCBT) CRISPR for VWA3A
- GenScript: Design CRISPR guide RNA sequences for VWA3A
miRNA Products
- Search ViGene Biosciences for VWA3A
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for VWA3A
- Browse OriGene Inhibitory RNA Products For VWA3A
-
ViGene Biosciences ready-to-package AAV shRNAs for VWA3A gene
Clone Products
- VectorBuilder custom plasmid, inducible vectors for VWA3A
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for VWA3A
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for VWA3A
-
ViGene Biosciences adenoviral particle packaged cDNA for VWA3A gene
-
ViGene Biosciences lentiviral particle packaged cDNA for VWA3A gene
-
ViGene Biosciences ready-to-package AAV shRNAs for VWA3A gene
No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for VWA3A Gene
Localization for VWA3A Gene
Subcellular locations from UniProtKB/Swiss-Prot for VWA3A Gene
- Secreted.
| Compartment | Confidence |
|---|---|
| extracellular | 3 |
| mitochondrion | 2 |
| cytosol | 2 |
| nucleus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | IEA | -- |
Transcripts for VWA3A Gene
mRNA/cDNA for VWA3A Gene
- (9) REFSEQ mRNAs :
- (7) Additional mRNA sequences :
- (32) Selected AceView cDNA sequences:
- (8) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for VWA3A Gene
CRISPR Products
-
OriGene CRISPR knockouts for VWA3A
-
Santa Cruz Biotechnology (SCBT) CRISPR for VWA3A
- GenScript: Design CRISPR guide RNA sequences for VWA3A
miRNA Products
- Search ViGene Biosciences for VWA3A
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for VWA3A
- Browse OriGene Inhibitory RNA Products For VWA3A
-
ViGene Biosciences ready-to-package AAV shRNAs for VWA3A gene
Clone Products
- VectorBuilder custom plasmid, inducible vectors for VWA3A
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for VWA3A
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19a | · | 19b | ^ | 20 | ^ | 21a | · | 21b | ^ | 22 | ^ | 23 | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - |
| ExUns: | 24 | ^ | 25a | · | 25b | ^ | 26 | ^ | 27 | ^ | 28 | ^ | 29 | ^ | 30 | ^ | 31 | ^ | 32 | ^ | 33a | · | 33b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||||||||||||
| SP2: | |||||||||||||||||||||||
| SP3: | |||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||
| SP5: |
Expression for VWA3A Gene
mRNA differential expression in normal tissues according to GTEx for VWA3A Gene
This gene is overexpressed in Cervix - Endocervix (x8.9), Pituitary (x8.7), and Fallopian Tube (x5.2).
This gene is overexpressed in Plasma (39.2), Serum (21.6), and Seminal vesicle (7.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for VWA3A Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of VWA3A Gene:
VWA3ASOURCE GeneReport for Unigene cluster for VWA3A Gene:
Hs.10697Evidence on tissue expression from TISSUES for VWA3A Gene
- Nervous system(4.2)
Primer Products
-
OriGene qPCR primer pairs for VWA3A
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for VWA3A Gene
Orthologs for VWA3A Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | VWA3A 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | VWA3A 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | VWA3A 34 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Vwa3a 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Vwa3a 34 16 35 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | VWA3A 35 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | VWA3A 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | VWA3A 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | VWA3A 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | vwa3a 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | LOC100535802 34 |
|
||
| VWA3A 35 |
|
OneToOne | |||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
OneToOne |
- Species where no ortholog for VWA3A was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for VWA3A Gene
(1) SIMAP similar genes for VWA3A Gene using alignment to 5 proteins:
Variants for VWA3A Gene
| SNP ID | Clin | Chr 16 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000032270 | -- | 22,127,795(+) | TGGCC(C/T)AACAG | intron-variant | |
| rs1000058282 | -- | 22,124,503(+) | TACAA(A/C)GTATT | intron-variant | |
| rs1000100238 | -- | 22,120,676(+) | GGTGA(A/C)CTGTC | intron-variant, upstream-variant-2KB | |
| rs1000189972 | -- | 22,092,497(+) | TTACC(C/T)TGGAG | intron-variant, upstream-variant-2KB | |
| rs1000210271 | -- | 22,138,680(+) | TCCCG(C/T)GGGGG | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv3n1 | OTHER | inversion | 15895083 |
| dgv47n16 | OTHER | inversion | 17901297 |
| esv3368991 | OTHER | inversion | 20981092 |
| esv3638195 | CNV | gain | 21293372 |
| esv3638196 | CNV | gain | 21293372 |
| esv3638198 | CNV | gain | 21293372 |
| esv3638199 | CNV | loss | 21293372 |
| esv998989 | OTHER | inversion | 20482838 |
| nsv1077770 | OTHER | inversion | 25765185 |
| nsv1140248 | OTHER | inversion | 24896259 |
| nsv469628 | CNV | gain | 16826518 |
| nsv469818 | CNV | loss | 16826518 |
| nsv499139 | OTHER | inversion | 21111241 |
| nsv7280 | OTHER | inversion | 18451855 |
Residual Variation Intolerance Score:
96.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
6.02;
74.97% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for VWA3A Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- VWA3A
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VWA3A Gene
Disorders for VWA3A Gene
Relevant External Links for VWA3A
No disorders were found for VWA3A Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for VWA3A Gene
Publications for VWA3A Gene
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 64
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64
- The sequence and analysis of duplication-rich human chromosome 16. (PMID: 15616553) Martin J. … Pennacchio L.A. (Nature 2004) 4 64
Products for VWA3A Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
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- OriGene Purified Proteins for VWA3A
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- Origene Custom Protein Services for VWA3A
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for VWA3A
- Browse OriGene Inhibitory RNA Products For VWA3A
- OriGene qPCR primer pairs for VWA3A
- OriGene CRISPR knockouts for VWA3A
- OriGene ORF clones in human for VWA3A
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For VWA3A
- GenScript: Next-day shipping cDNA ORF clone for VWA3A in any vector
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- GenScript Custom Assay Services for VWA3A
- GenScript Custom overexpressing Cell Line Services for VWA3A
- GenScript: Design CRISPR guide RNA sequences for VWA3A
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
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- Novus Biologicals Antibodies for VWA3A
- Novus Biologicals proteins for VWA3A
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Cloud-Clone Corp. Antibodies for VWA3A
- Cloud-Clone Corp. Proteins for VWA3A
- Cloud-Clone Corp Assay Kits for VWA3A
- Invitrogen Antibodies for VWA3A
- Search GeneTex for Antibodies for VWA3A
- Search GeneTex for Proteins for VWA3A
- ViGene Biosciences adenoviral particle packaged cDNA for VWA3A gene
- ViGene Biosciences lentiviral particle packaged cDNA for VWA3A gene
- ViGene Biosciences ready-to-package AAV shRNAs for VWA3A gene
- Search ViGene Biosciences for VWA3A
- Horizon Cell Lines for VWA3A
- Cyagen custom Knockout/knockin (KOKI) mouse models for VWA3A
- VectorBuilder custom plasmid, inducible vectors for VWA3A
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for VWA3A
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for VWA3A Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
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- (122) diseasecard
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- (124) Orphanet
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- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer