VWA3A Gene
protein-coding GIFtS: 40
GCID: GC16P022103
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|
Von Willebrand Factor A Domain Containing 3A
| |
Aliases
for VWA3A gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
10fRNAdb,
12H-InvDB,
13NCBI,
14NONCODE,
and/or 15RNAdb)
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| Aliases |
|---|
| Von Willebrand Factor A Domain Containing 3A1 2 | | Von Willebrand Factor A Domain-Containing Protein 3A2 |
Export aliases for VWA3A gene to outside databasesPrevious GC identifers: GC16P022015 GC16P020349 |
Summaries
for VWA3A gene(According to Entrez Gene,
GeneCards,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
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GeneCards Summary for VWA3A Gene:
VWA3A (von Willebrand factor A domain containing 3A) is a protein-coding gene. An important paralog of this gene is VWA3B.
|
Genomic Views
for VWA3A gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 75),
Regulatory elements and Epigenetics data according to
QIAGEN, and/or
SwitchGear Genomics)
About This Section
TryGeneCards Plus | RefSeq DNA sequence:- NC_000016.10 NT_187260.1 NC_018927.2
Regulatory elements:
 Regulatory transcription factor binding sites in the VWA3A gene promoter:
c-Fos SRY AP-1 Pbx1a POU2F1 POU2F1a FosB c-Jun MRF-2 Evi-1
Other transcription factors
Search Chromatin IP Primers for VWA3A
Epigenetics:
| | DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat VWA3A |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 16p12.2 Ensembl cytogenetic band: 16p12.2 HGNC cytogenetic band: 16p12.1VWA3A Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 16 GeneLoc Exon Structure GeneLoc location for GC16P022103: view genomic region
(about GC identifiers)
Start:
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22,103,859 bp from pter |
End:
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22,168,287 bp from pter |
Size:
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64,429 bases |
Orientation:
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plus strand |
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Proteins
for VWA3A gene
(According to
1UniProtKB,
HORDE,
2neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to PhosphoSitePlus,
Specific Peptides from DME,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Cloud-Clone Corp.,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Cloud-Clone Corp.,
Antibodies by
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
LSBio,
Abcam, and/or
Cloud-Clone Corp.)
About This Section
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UniProtKB/Swiss-Prot: VWA3A_HUMAN, A6NCI4 (See
protein sequence)Recommended Name: von Willebrand factor A domain-containing protein 3A precursor Size: 1184 amino acids; 134020 Da
Secondary accessions: A4QMU8 A6NNC0 Q6UTX4 Q6ZQZ9 Q8IUY6 Q8N9W1Alternative splicing: 4 isoforms: A6NCI4-1 A6NCI4-2 A6NCI4-3 A6NCI4-4 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for VWA3A: NX_A6NCI4
Explore proteomics data for VWA3A at MOPED
Post-translational modifications:  Glycosylation2 at Asn709 Modification sites at PhosphoSitePlus
See VWA3A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB
REFSEQ proteins: NP_775886.3
ENSEMBL proteins: ENSP00000457368 ENSP00000457770 ENSP00000374049 ENSP00000299840 ENSP00000457167 ENSP00000456513 ENSP00000374048
VWA3A Human Recombinant
Protein Products:VWA3A Antibody
Products:VWA3A Assay Products: |
Domains /
Families
for VWA3A gene(According to HGNC, IUPHAR, InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
TryGeneCards Plus | 1 InterPro protein domain:Graphical View of Domain Structure for InterPro Entry A6NCI4 ProtoNet protein and cluster: A6NCI4 UniProtKB/Swiss-Prot: VWA3A_HUMAN, A6NCI4Similarity: Contains 2 VWFA domains
VWA3A for domains About GeneDecksing
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Function
for VWA3A gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
genOway,
transcription factor targeting from QIAGEN
and/or HOMER,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
SwitchGear Genomics,
Gene Editing from DNA2.0,
Clones from OriGene,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
ESI BIO,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Apr 2014 via
Entrez Gene.)
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Animal Models:
Inhib. RNA
Products: |  | OriGene RNAi products in human, mouse, rat for VWA3A
| | | Predesigned siRNA for gene silencing in human, mouse, rat VWA3A |
Cell Line
Products: |  | GenScript Custom overexpressing Cell Line Services for VWA3A | |  | Browse ESI BIO Cell Lines and PureStem Progenitors for VWA3A  | In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VWA3A |
Localization
for VWA3A gene
(According to UniProtKB, COMPARTMENTS Subcellular localization database,
Ontologies according to Gene Ontology Consortium 01 Apr 2014 via
Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot VWA3A_HUMAN, A6NCI4: Secreted (Potential)Subcellular locations from COMPARTMENTS:
| Compartment | Confidence |
|---|
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| extracellular | 3 | | cytosol | 2 | | mitochondrion | 2 | | nucleus | 1 | | plasma membrane | 1 |
Gene Ontology (GO): 1 cellular component term: About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005576 | extracellular region |
IEA | -- |
VWA3A for ontologies About GeneDecksing
|
Pathways & Interactions
for VWA3A gene
(SuperPaths according to PathCards,
Pathways according to
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Sino Biological,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
QIAGEN,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2014 via
Entrez Gene).
About This Section
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Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for VWA3A
Interactions:
Search GeneGlobe Interaction Network for VWA3A
|
Drugs & Compounds
for VWA3A gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience,
ApexBio,
HMDB,
BitterDB, and/or
Novoseek,
Ligands according to IUPHAR,
and Drugs according to DrugBank,
Enzo Life Sciences, and/or
PharmGKB)
About This Section
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 Browse compounds at ApexBio
 Browse Tocris compounds for VWA3A
|
Transcripts
for VWA3A gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
Conferences by KenesGroup,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
SwitchGear Genomics,
Tagged/untagged cDNA clones from
OriGene,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene, and/or
QIAGEN
)
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REFSEQ mRNAs for VWA3A gene (2 alternative transcripts): NM_175059.2 NM_173615.4 Unigene Cluster for VWA3A: Von Willebrand factor A domain containing 3A Hs.10697 [show with all ESTs]Unigene Representative Sequence: NM_1736159 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000562340 ENST00000567131 ENST00000566668 ENST00000568328 ENST00000389398(uc010bxc.2 uc010vbq.2 uc010bxd.3 uc002dkg.4)
ENST00000299840 ENST00000563389 ENST00000563755 ENST00000389397(uc010bxe.1)
Inhib. RNA
Products: | | OriGene RNAi products in human, mouse, rat for VWA3A
| |
| | Predesigned siRNA for gene silencing in human, mouse, rat VWA3A |
Primer
Products: | | OriGene qSTAR qPCR primer pairs in human, mouse for VWA3A
| | | Pre-validated RT2 qPCR Primer Assay in human, mouse, rat VWA3A | | | QuantiTect SYBR Green Assays in human, mouse, rat VWA3A | | | QuantiFast Probe-based Assays in human, mouse, rat VWA3A |
Additional mRNA sequence: AK093467.1 AK128606.1 AK307544.1 AY360464.1 BC038400.1 BC109294.1 BC109295.1 8 DOTS entries: DT.407129 DT.99998669 DT.100019005 DT.120658560 DT.120658938 DT.91923781 DT.120658787 DT.91666892 Selected AceView cDNA sequences (see all 32): BC038400 BF739772 CB241886 BU684516 AX748144 AA398185 AA781930 CB241369 BM998658 BI916787 BX114698 AY360464 AK128606 BE466460 BU683697 AI016658 N47075 AI192034 AK098260 AK093467 BI755006 BG570684 BI035585 CD705779
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for VWA3A About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19a | · | 19b | ^ | 20 | ^ | 21a | · | 21b | ^ | 22 | ^ | 23 | ^ |
|---|
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| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | - | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 24 | ^ | 25a | · | 25b | ^ | 26 | ^ | 27 | ^ | 28 | ^ | 29 | ^ | 30 | ^ | 31 | ^ | 32 | ^ | 33a | · | 33b |
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| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for VWA3A
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Expression
for VWA3A gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
Protein expression images according to data from SPIRE 1MOPED,
2PaxDb, and 3MaxQB,
plus additional links to
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
QIAGEN,
Primers from
OriGene, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
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VWA3A expression in normal human tissues
(normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: ACTTTAACTG
About this image VWA3A Protein expression data from MOPED1, PaxDb2 and
MaxQB3: About this image
SOURCE GeneReport for Unigene cluster: Hs.10697
Custom PCR Arrays for VWA3A
Primer
Products: | | OriGene qSTAR qPCR primer pairs in human, mouse for VWA3A
| | | Pre-validated RT2 qPCR Primer Assay in human, mouse, rat VWA3A | | | QuantiTect SYBR Green Assays in human, mouse, rat VWA3A | | | QuantiFast Probe-based Assays in human, mouse, rat VWA3A | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VWA3A |
Orthologs
for VWA3A gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the common ancestor of chordates.
Orthologs for VWA3A gene from Selected species (see all 12) About this table
ENSEMBL Gene Tree for VWA3A (if available)
TreeFam Gene Tree for VWA3A (if available) |
Paralogs
for VWA3A gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
TryGeneCards Plus | Paralogs for VWA3A gene
- VWA3B2
1 SIMAP similar gene for VWA3A using alignment to 5 protein entries: VWA3A_HUMAN (see all proteins):VWA3B
VWA3A for paralogs About GeneDecksing
|
Genomic Variants
for VWA3A gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
4UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD), the Human Cytochrome P450 Allele
Nomenclature Database, and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section
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| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 16 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for VWA3A (22103859 - 22168287 bp)
Structural Variations
Database of Genomic Variants (DGV) Selected variations for VWA3A (see all 18): About this table
| | Site Specific Mutation Identification with PCR Assays |
| | SeqTarget long-range PCR primers for resequencing VWA3A |
|
Disorders
/ Diseases
for VWA3A gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Conferences by KenesGroup,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
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VWA3A for disorders About GeneDecksing
Genetic Association Database (GAD): VWA3A
Export disorders for VWA3A gene to outside databases
|
Publications
for VWA3A gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
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PubMed articles for VWA3A gene integrated from 10 sources:
(articles sorted by number of sources associating them with VWA3A) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
- The sequence and analysis of duplication-rich human chromosome 16. (PubMed id 15616553)2 Martin J.... Pennacchio L.A. (Nature 2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
- The sequence of the human genome. (PubMed id 11181995)1 Venter J.C.... Zhu X. (Science 2001)
- (PubMed id )2
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External Searches for VWA3A gene (in PubMed,
OMIM, and NCBI Bookshelf)
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|
Genome Databases showing VWA3A gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
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|
Other Databases showing VWA3A gene
(According to HUGE)
About This Section
TryGeneCards Plus | -- |
Specialized Databases showing VWA3A gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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| Name | Description |
| PharmGKB entry for VWA3A | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
TryGeneCards Plus | Patent Information for VWA3A gene:
Search GeneIP for patents involving VWA3A
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for VWA3A gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or
ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory,
genOway)
About This Section
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 | |
 |
| | | | |
 |
 |
|  | Block miRNA regulation of human, mouse, rat VWA3A using miScript Target Protectors | | SeqTarget long-range PCR primers for resequencing VWA3A | | | DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat VWA3A | | Predesigned siRNA for gene silencing in human, mouse, rat VWA3A | | | QuantiFast Probe-based Assays in human, mouse, rat VWA3A | | QuantiTect SYBR Green Assays in human, mouse, rat VWA3A | | | Custom PCR Arrays for VWA3A | | Search Chromatin IP Primers for VWA3A | | | Pre-validated RT2 qPCR Primer Assay in human, mouse, rat VWA3A | | Search GeneGlobe Interaction Network for VWA3A | | | Regulatory tfbs in VWA3A promoter |
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 |  |  |  | |
| | | Search Tocris compounds for VWA3A |
| | |  |  |  |
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 |
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 |  | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VWA3A |
| |  |  |  |  | | | ThermoFisher Antibodies for VWA3A |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat VWA3A |
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