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Aliases for VWA2 Gene

Aliases for VWA2 Gene

  • Von Willebrand Factor A Domain Containing 2 2 3
  • A Domain-Containing Protein Similar To Matrilin And Collagen 3 4
  • Colon Cancer Secreted Protein 2 3 4
  • CCSP-2 3 4
  • AMACO 3 4
  • Von Willebrand Factor A Domain-Containing Protein 2 3
  • Colon Cancer Diagnostic Marker 3
  • NET42 3

External Ids for VWA2 Gene

Previous GeneCards Identifiers for VWA2 Gene

  • GC10P115990
  • GC10P109626

Summaries for VWA2 Gene

Entrez Gene Summary for VWA2 Gene

  • This gene encodes a member of the von Willebrand factor A-like domain protein superfamily. The encoded protein is localized to the extracellular matrix and may serve as a structural component in basement membranes or in anchoring structures on scaffolds of collagen VII or fibrillin. This gene has been linked to type 1A diabetes and is a candidate serological marker for colon cancer. [provided by RefSeq, Jan 2013]

GeneCards Summary for VWA2 Gene

VWA2 (Von Willebrand Factor A Domain Containing 2) is a Protein Coding gene. An important paralog of this gene is MATN1.

Gene Wiki entry for VWA2 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VWA2 Gene

Genomics for VWA2 Gene

Regulatory Elements for VWA2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for VWA2 Gene

114,239,254 bp from pter
114,294,500 bp from pter
55,247 bases
Plus strand

Genomic View for VWA2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for VWA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VWA2 Gene

Proteins for VWA2 Gene

  • Protein details for VWA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    von Willebrand factor A domain-containing protein 2
    Protein Accession:
    Secondary Accessions:
    • A1A5D4
    • B5MDJ8
    • Q6ZS39
    • Q6ZWJ7
    • Q708C5
    • Q70UZ8

    Protein attributes for VWA2 Gene

    755 amino acids
    Molecular mass:
    82012 Da
    Quaternary structure:
    • Forms monomers and multimers.
    • May be used as a serological marker for colon neoplasia

    Alternative splice isoforms for VWA2 Gene


neXtProt entry for VWA2 Gene

Proteomics data for VWA2 Gene at MOPED

Post-translational modifications for VWA2 Gene

Other Protein References for VWA2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for VWA2 Gene

Domains for VWA2 Gene

Protein Domains for VWA2 Gene


Suggested Antigen Peptide Sequences for VWA2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 2 EGF-like domains.
  • Contains 2 EGF-like domains.
  • Contains 3 VWFA domains.
genes like me logo Genes that share domains with VWA2: view

No data available for Gene Families for VWA2 Gene

Function for VWA2 Gene

Gene Ontology (GO) - Molecular Function for VWA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding --
GO:0005515 protein binding IPI 25416956
GO:0042802 identical protein binding IDA 14506275
genes like me logo Genes that share ontologies with VWA2: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for VWA2

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for VWA2 Gene

Localization for VWA2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for VWA2 Gene


Subcellular locations from

Jensen Localization Image for VWA2 Gene COMPARTMENTS Subcellular localization image for VWA2 gene
Compartment Confidence
extracellular 5
cytosol 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for VWA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region --
GO:0005604 basement membrane IEA --
GO:0005615 extracellular space IDA 14506275
GO:0070062 extracellular exosome IDA 19199708
genes like me logo Genes that share ontologies with VWA2: view

Pathways for VWA2 Gene

SuperPathways for VWA2 Gene

No Data Available

Interacting Proteins for VWA2 Gene

Selected Interacting proteins: Q5GFL6-VWA2_HUMAN for VWA2 Gene via UniProtKB

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for VWA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007161 calcium-independent cell-matrix adhesion IEA --
GO:0046626 regulation of insulin receptor signaling pathway IMP 15699509
GO:0051260 protein homooligomerization IDA 14506275
genes like me logo Genes that share ontologies with VWA2: view

No data available for Pathways by source for VWA2 Gene

Transcripts for VWA2 Gene

mRNA/cDNA for VWA2 Gene

(12) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(8) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for VWA2 Gene

Von Willebrand factor A domain containing 2:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for VWA2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for VWA2 Gene

No ASD Table

Relevant External Links for VWA2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for VWA2 Gene

mRNA expression in normal human tissues for VWA2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for VWA2 Gene

This gene is overexpressed in Stomach (7.0).

Protein differential expression in normal tissues for VWA2 Gene

This gene is overexpressed in Heart (35.6), Fetal heart (22.0), and Pancreas (9.8).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for VWA2 Gene

SOURCE GeneReport for Unigene cluster for VWA2 Gene Hs.197741

mRNA Expression by UniProt/SwissProt for VWA2 Gene

Tissue specificity: Expression is generally absent in normal colon and other normal body tissues, but it is induced an average of 78-fold in Stage II, III, and IV colon cancers, as well as in colon adenomas and colon cancer cell lines.
genes like me logo Genes that share expressions with VWA2: view

Expression partners for VWA2 Gene

* - Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

Orthologs for VWA2 Gene

This gene was present in the common ancestor of animals.

Orthologs for VWA2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia VWA2 35
  • 82.91 (n)
  • 79.95 (a)
VWA2 36
  • 72 (a)
(Canis familiaris)
Mammalia VWA2 35
  • 85.61 (n)
  • 82.2 (a)
VWA2 36
  • 75 (a)
(Mus musculus)
Mammalia Vwa2 35
  • 81.78 (n)
  • 80.59 (a)
Vwa2 16
Vwa2 36
  • 72 (a)
(Pan troglodytes)
Mammalia VWA2 35
  • 98.19 (n)
  • 97.34 (a)
VWA2 36
  • 92 (a)
(Rattus norvegicus)
Mammalia Vwa2 35
  • 81.21 (n)
  • 79.39 (a)
(Monodelphis domestica)
Mammalia VWA2 36
  • 63 (a)
(Ornithorhynchus anatinus)
Mammalia VWA2 36
  • 55 (a)
(Gallus gallus)
Aves VWA2 35
  • 65.42 (n)
  • 60.56 (a)
VWA2 36
  • 54 (a)
(Anolis carolinensis)
Reptilia VWA2 36
  • 51 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia vwa2 35
  • 62.48 (n)
  • 54.41 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.1564 35
(Danio rerio)
Actinopterygii vwa2 35
  • 59.66 (n)
  • 51.21 (a)
vwa2 36
  • 45 (a)
(Caenorhabditis elegans)
Secernentea mup-4 36
  • 6 (a)
Species with no ortholog for VWA2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for VWA2 Gene

Gene Tree for VWA2 (if available)
Gene Tree for VWA2 (if available)

Paralogs for VWA2 Gene

Paralogs for VWA2 Gene

(2) SIMAP similar genes for VWA2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with VWA2: view

Variants for VWA2 Gene

Sequence variations from dbSNP and Humsavar for VWA2 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs476525 -- 114,275,115(+) ggtcA(C/T)ctagg intron-variant
rs489262 -- 114,259,186(-) tgttt(A/T)cgggg intron-variant
rs526930 -- 114,265,563(+) ATCCA(A/G)TAGGC intron-variant
rs538262 -- 114,242,599(+) TCTCT(C/G)TGTAC intron-variant
rs540609 -- 114,280,242(+) CACTG(A/G)GGGCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for VWA2 Gene

Variant ID Type Subtype PubMed ID
nsv7211 OTHER Inversion 18451855
esv2646179 CNV Insertion 19546169
dgv826n71 CNV Loss 21882294

Relevant External Links for VWA2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VWA2 Gene

Disorders for VWA2 Gene

Relevant External Links for VWA2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for VWA2 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for VWA2 Gene

Publications for VWA2 Gene

  1. Identification and characterization of AMACO, a new member of the von Willebrand factor A-like domain protein superfamily with a regulated expression in the kidney. (PMID: 14506275) Sengle G. … Wagener R. (J. Biol. Chem. 2003) 2 3 4 23
  2. Colon cancer secreted protein-2 (CCSP-2), a novel candidate serological marker of colon neoplasia. (PMID: 15580307) Xin B. … Markowitz S. (Oncogene 2005) 2 3 4 23
  3. O-glucosylation and O-fucosylation occur together in close proximity on the first epidermal growth factor repeat of AMACO (VWA2 protein). (PMID: 18434322) Gebauer J.M. … Wagener R. (J. Biol. Chem. 2008) 3 23
  4. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A. … Goate A. (Am. J. Hum. Genet. 2006) 3 48
  5. Extensive contacts between ADAMTS13 exosites and von Willebrand factor domain A2 contribute to substrate specificity. (PMID: 18492952) Gao W. … Sadler J.E. (Blood 2008) 3

Products for VWA2 Gene

Sources for VWA2 Gene

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