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Aliases for VWA1 Gene

Aliases for VWA1 Gene

  • Von Willebrand Factor A Domain Containing 1 2 3
  • WARP 3 6
  • Von Willebrand Factor A Domain-Containing Protein 1 3
  • Von Willebrand Factor A Domain-Related Protein 3

External Ids for VWA1 Gene

Previous GeneCards Identifiers for VWA1 Gene

  • GC01P001457
  • GC01P001360
  • GC01P000645
  • GC01P001370

Summaries for VWA1 Gene

Entrez Gene Summary for VWA1 Gene

  • VWA1 belongs to the von Willebrand factor (VWF; MIM 613160) A (VWFA) domain superfamily of extracellular matrix proteins and appears to play a role in cartilage structure and function (Fitzgerald et al., 2002 [PubMed 12062410]).[supplied by OMIM, Nov 2010]

GeneCards Summary for VWA1 Gene

VWA1 (Von Willebrand Factor A Domain Containing 1) is a Protein Coding gene. GO annotations related to this gene include identical protein binding. An important paralog of this gene is MATN1.

UniProtKB/Swiss-Prot for VWA1 Gene

  • Promotes matrix assembly.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VWA1 Gene

Genomics for VWA1 Gene

Regulatory Elements for VWA1 Gene

Genomic Location for VWA1 Gene

Start:
1,434,861 bp from pter
End:
1,442,882 bp from pter
Size:
8,022 bases
Orientation:
Plus strand

Genomic View for VWA1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for VWA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VWA1 Gene

Proteins for VWA1 Gene

  • Protein details for VWA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6PCB0-VWA1_HUMAN
    Recommended name:
    von Willebrand factor A domain-containing protein 1
    Protein Accession:
    Q6PCB0
    Secondary Accessions:
    • A8K692
    • B3KUA1
    • E9PB53
    • Q7L5D7
    • Q9H6J5

    Protein attributes for VWA1 Gene

    Size:
    445 amino acids
    Molecular mass:
    46804 Da
    Quaternary structure:
    • Homodimer or homomultimer. Interacts with HSPG2 (By similarity).

    Alternative splice isoforms for VWA1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for VWA1 Gene

Proteomics data for VWA1 Gene at MOPED

Post-translational modifications for VWA1 Gene

Other Protein References for VWA1 Gene

No data available for DME Specific Peptides for VWA1 Gene

Domains for VWA1 Gene

Gene Families for VWA1 Gene

HGNC:
  • FN3 :Fibronectin type III domain containing

Protein Domains for VWA1 Gene

Suggested Antigen Peptide Sequences for VWA1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6PCB0

UniProtKB/Swiss-Prot:

VWA1_HUMAN :
  • Q6PCB0
Domain:
  • Contains 2 fibronectin type-III domains.
  • Contains 1 VWFA domain.
genes like me logo Genes that share domains with VWA1: view

Function for VWA1 Gene

Molecular function for VWA1 Gene

UniProtKB/Swiss-Prot Function: Promotes matrix assembly.

Gene Ontology (GO) - Molecular Function for VWA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0042802 identical protein binding IEA --
genes like me logo Genes that share ontologies with VWA1: view
genes like me logo Genes that share phenotypes with VWA1: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for VWA1 Gene

Localization for VWA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for VWA1 Gene

Secreted, extracellular space, extracellular matrix, basement membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for VWA1 Gene COMPARTMENTS Subcellular localization image for VWA1 gene
Compartment Confidence
extracellular 2
plasma membrane 2
endoplasmic reticulum 1
lysosome 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for VWA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region --
GO:0005604 basement membrane IEA --
GO:0005614 interstitial matrix IEA --
GO:0005615 extracellular space IDA 16502470
GO:0031012 extracellular matrix --
genes like me logo Genes that share ontologies with VWA1: view

Pathways for VWA1 Gene

SuperPathways for VWA1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for VWA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030198 extracellular matrix organization IEA --
GO:0048266 behavioral response to pain IEA --
genes like me logo Genes that share ontologies with VWA1: view

No data available for Pathways by source for VWA1 Gene

Transcripts for VWA1 Gene

Unigene Clusters for VWA1 Gene

Von Willebrand factor A domain containing 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for VWA1 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b · 3c
SP1: - -
SP2:
SP3: -

Relevant External Links for VWA1 Gene

GeneLoc Exon Structure for
VWA1
ECgene alternative splicing isoforms for
VWA1

Expression for VWA1 Gene

mRNA expression in normal human tissues for VWA1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for VWA1 Gene

SOURCE GeneReport for Unigene cluster for VWA1 Gene Hs.449009

genes like me logo Genes that share expressions with VWA1: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for VWA1 Gene

Orthologs for VWA1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for VWA1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia VWA1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia VWA1 35
  • 83.5 (n)
  • 85.44 (a)
VWA1 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia VWA1 35
  • 84.09 (n)
  • 83.41 (a)
VWA1 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Vwa1 35
  • 80.71 (n)
  • 80.46 (a)
Vwa1 16
Vwa1 36
  • 79 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia VWA1 36
  • 51 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia VWA1 36
  • 1 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Vwa1 35
  • 80.29 (n)
  • 79.95 (a)
chicken
(Gallus gallus)
Aves VWA1 35
  • 62.4 (n)
  • 54.77 (a)
VWA1 36
  • 42 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia VWA1 36
  • 55 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100485693 35
  • 56.23 (n)
  • 54.29 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC568379 35
  • 50.67 (n)
  • 39.35 (a)
vwa1 36
  • 30 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10963 36
  • 8 (a)
OneToMany
Species with no ortholog for VWA1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for VWA1 Gene

ENSEMBL:
Gene Tree for VWA1 (if available)
TreeFam:
Gene Tree for VWA1 (if available)

Paralogs for VWA1 Gene

Paralogs for VWA1 Gene

Selected SIMAP similar genes for VWA1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with VWA1: view

Variants for VWA1 Gene

Sequence variations from dbSNP and Humsavar for VWA1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs4590 -- 1,440,430(-) GTCAC(C/G)TGTCC utr-variant-3-prime
rs11313 -- 1,439,978(+) GGCTG(C/G)GGCCT utr-variant-3-prime
rs11805 -- 1,439,312(+) GTCCA(A/G)CGTGN reference, missense, utr-variant-3-prime
rs13683 -- 1,440,567(+) CTTCT(G/T)GCTGT utr-variant-3-prime
rs711180 -- 1,442,793(-) CCACG(C/T)TTGGA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for VWA1 Gene

Variant ID Type Subtype PubMed ID
nsv10161 CNV Gain+Loss 18304495
dgv10n71 CNV Loss 21882294
dgv12n71 CNV Loss 21882294
dgv19n71 CNV Loss 21882294
dgv20n71 CNV Loss 21882294
dgv25n71 CNV Loss 21882294
dgv30n71 CNV Gain 21882294
dgv31n71 CNV Gain 21882294
dgv32n71 CNV Gain+Loss 21882294
dgv33n71 CNV Loss 21882294
dgv34n71 CNV Loss 21882294
dgv38n71 CNV Loss 21882294
nsv871837 CNV Loss 21882294
nsv871690 CNV Gain 21882294
essv5472 CNV CNV 17122850
dgv9e1 CNV Complex 17122850
dgv40n71 CNV Loss 21882294
nsv871787 CNV Loss 21882294
dgv41n71 CNV Gain 21882294

Relevant External Links for VWA1 Gene

HapMap Linkage Disequilibrium report
VWA1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VWA1 Gene

Disorders for VWA1 Gene

No disorders were found for VWA1 Gene.

No data available for UniProtKB/Swiss-Prot for VWA1 Gene

Publications for VWA1 Gene

  1. Is there an evolutionary relationship between WARP (von Willebrand factor A-domain-related protein) and the FACIT and FACIT-like collagens? (PMID: 14527666) Fitzgerald J. … Bateman J.F. (FEBS Lett. 2003) 2 3 23
  2. WARP is a new member of the von Willebrand factor A-domain superfamily of extracellular matrix proteins. (PMID: 12062410) Fitzgerald J. … Bateman J.F. (FEBS Lett. 2002) 2 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. WARP is a novel multimeric component of the chondrocyte pericellular matrix that interacts with perlecan. (PMID: 16407285) Allen J.M. … Fitzgerald J. (J. Biol. Chem. 2006) 3
  5. Human colostrum: identification of minor proteins in the aqueous phase by proteomics. (PMID: 16502470) Palmer D.J. … Cooper G.J. (Proteomics 2006) 3

Products for VWA1 Gene

Sources for VWA1 Gene

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