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Aliases for VTRNA2-1 Gene

Subcategory (RNA class) for VTRNA2-1 Gene

vault RNA

Quality Score for this RNA gene is


Aliases for VTRNA2-1 Gene

  • Vault RNA 2-1 2 3 5
  • MicroRNA 886 2 3
  • Cord Blood Lymphocyte-Derived Noncoding RNA 3 3
  • Noncoding RNA 886 3
  • Vault RNA 2 2
  • Hsa-Mir-886 3
  • SvtRNA2-1a 3
  • MIRN886 3
  • MIR886 3
  • VTRNA2 3
  • CBL-3 3
  • Hvg-5 3
  • Nc886 3
  • CBL3 3

External Ids for VTRNA2-1 Gene

ORGUL Members for VTRNA2-1 Gene

Previous HGNC Symbols for VTRNA2-1 Gene

  • MIR886
  • MIRN886
  • VTRNA2

Previous GeneCards Identifiers for VTRNA2-1 Gene

  • GC05M135417

Summaries for VTRNA2-1 Gene

Entrez Gene Summary for VTRNA2-1 Gene

  • This gene produces an RNA polymerase III transcript that resembles both a component of the ribonucleoprotein vault particle and a pre-microRNA. However, the RNA product does not function as a vault or microRNA; rather, it acts as a direct inhibitor of protein kinase R (also known as eukaryotic translation initiation factor 2-alpha kinase 2, EIF2AK2), and thereby plays an important role in the regulation of cell growth. This gene is located in the vicinity of a differentially methylated region (DMR) and is imprinted and may show allele-specific expression. This gene is also often hypermethylated and repressed in cancers. [provided by RefSeq, Nov 2015]

GeneCards Summary for VTRNA2-1 Gene

VTRNA2-1 (Vault RNA 2-1) is an RNA Gene, and is affiliated with the vault RNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VTRNA2-1 Gene

Genomics for VTRNA2-1 Gene

Regulatory Elements for VTRNA2-1 Gene

Enhancers for VTRNA2-1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around VTRNA2-1 on UCSC Golden Path with GeneCards custom track

Promoters for VTRNA2-1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around VTRNA2-1 on UCSC Golden Path with GeneCards custom track

Genomic Location for VTRNA2-1 Gene

136,080,471 bp from pter
136,080,597 bp from pter
127 bases
Minus strand

Genomic View for VTRNA2-1 Gene

Genes around VTRNA2-1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
VTRNA2-1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for VTRNA2-1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VTRNA2-1 Gene

Proteins for VTRNA2-1 Gene

Post-translational modifications for VTRNA2-1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for VTRNA2-1 Gene

Domains & Families for VTRNA2-1 Gene

Gene Families for VTRNA2-1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with VTRNA2-1: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for VTRNA2-1 Gene

Function for VTRNA2-1 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for VTRNA2-1 Gene

Localization for VTRNA2-1 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for VTRNA2-1 Gene

Pathways & Interactions for VTRNA2-1 Gene

SuperPathways for VTRNA2-1 Gene

No Data Available

Interacting Proteins for VTRNA2-1 Gene

Gene Ontology (GO) - Biological Process for VTRNA2-1 Gene


No data available for Pathways by source and SIGNOR curated interactions for VTRNA2-1 Gene

Drugs & Compounds for VTRNA2-1 Gene

No Compound Related Data Available

Transcripts for VTRNA2-1 Gene

mRNA/cDNA for VTRNA2-1 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for VTRNA2-1 Gene

No ASD Table

Relevant External Links for VTRNA2-1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for VTRNA2-1 Gene

mRNA expression in normal human tissues for VTRNA2-1 Gene

mRNA differential expression in normal tissues according to GTEx for VTRNA2-1 Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (x5.9).
genes like me logo Genes that share expression patterns with VTRNA2-1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for VTRNA2-1 Gene

Orthologs for VTRNA2-1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for VTRNA2-1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia Vault 36
  • 67 (a)
(Canis familiaris)
Mammalia Vault 36
  • 64 (a)
(Monodelphis domestica)
Mammalia Vault 36
  • 50 (a)
(Ornithorhynchus anatinus)
Mammalia Vault 36
  • 58 (a)
Vault 36
  • 66 (a)
Vault 36
  • 57 (a)
Vault 36
  • 62 (a)
Vault 36
  • 57 (a)
Vault 36
  • 56 (a)
Vault 36
  • 62 (a)
(Pan troglodytes)
Mammalia Vault 36
  • 100 (a)
(Gallus gallus)
Aves Vault 36
  • 64 (a)
(Anolis carolinensis)
Reptilia Vault 36
  • 57 (a)
(Danio rerio)
Actinopterygii Vault 36
  • 50 (a)
Vault 36
  • 49 (a)
Vault 36
  • 47 (a)
sea squirt
(Ciona savignyi)
Ascidiacea Vault 36
  • 46 (a)
Species with no ortholog for VTRNA2-1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for VTRNA2-1 Gene

Gene Tree for VTRNA2-1 (if available)
Gene Tree for VTRNA2-1 (if available)

Paralogs for VTRNA2-1 Gene

No data available for Paralogs for VTRNA2-1 Gene

Variants for VTRNA2-1 Gene

Sequence variations from dbSNP and Humsavar for VTRNA2-1 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs917303 -- 136,082,343(-) ATATG(C/T)TATTC upstream-variant-2KB
rs12653557 -- 136,082,209(+) TTTTT(G/T)TGTTT upstream-variant-2KB
rs2346019 -- 136,080,037(+) TACAG(A/G)CCGCC downstream-variant-500B
rs4976364 -- 136,081,514(+) ACAGA(A/C)CCAAA upstream-variant-2KB
rs34577747 -- 136,080,132(+) TGGCG(G/T)GTGGC downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for VTRNA2-1 Gene

Variant ID Type Subtype PubMed ID
dgv1853e1 CNV Complex 17122850
nsv5017 CNV Insertion 18451855

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Variation tolerance and Relevant External Links for VTRNA2-1 Gene

Disorders for VTRNA2-1 Gene

Relevant External Links for VTRNA2-1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for VTRNA2-1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for VTRNA2-1 Gene

Publications for VTRNA2-1 Gene

  1. Cell death/proliferation roles for nc886, a non-coding RNA, in the protein kinase R pathway in cholangiocarcinoma. (PMID: 22926522) Kunkeaw N. … Lee Y.S. (Oncogene 2013) 2 3 67
  2. Epstein-barr virus-induced expression of a novel human vault RNA. (PMID: 19298825) Nandy C. … Polacek N. (J. Mol. Biol. 2009) 2 3
  3. Evolution of vault RNAs. (PMID: 19491402) Stadler P.F. … Ullmann K. (Mol. Biol. Evol. 2009) 2 3
  4. Independent genomewide screens identify the tumor suppressor VTRNA2-1 as a human epiallele responsive to periconceptional environment. (PMID: 26062908) Silver M.J. … Waterland R.A. (Genome Biol. 2015) 3
  5. A Significant Upregulation of miR5-886-p in High Grade and Invasive Bladder Tumors. (PMID: 26135932) Khoshnevisan A. … Mowla S.J. (Urol J 2015) 3

Products for VTRNA2-1 Gene

Sources for VTRNA2-1 Gene