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Aliases for VTRNA1-1 Gene

Subcategory (RNA class) for VTRNA1-1 Gene

vault RNA

Quality Score for this RNA gene is


Aliases for VTRNA1-1 Gene

  • Vault RNA 1-1 2 3 5
  • Vault RNA Component 1 2 3
  • VAULTRC1 3
  • Hvg-1 3
  • HVG1 3
  • VRNA 3
  • VR1 3

External Ids for VTRNA1-1 Gene

ORGUL Members for VTRNA1-1 Gene

Previous HGNC Symbols for VTRNA1-1 Gene


Previous GeneCards Identifiers for VTRNA1-1 Gene

  • GC05P140075
  • GC05P135238
  • GC05P140091
  • GC05P140094
  • GC05P140109
  • GC05P141421
  • GC05P141565
  • GC05P141667
  • GC05P141768
  • GC05P141868
  • GC05P141977

Summaries for VTRNA1-1 Gene

Entrez Gene Summary for VTRNA1-1 Gene

  • Vaults are large cytoplasmic ribonucleoproteins of about 13 MD. They are composed of a major vault protein, MVP (MIM 605088), 2 minor vault proteins, TEP1 (MIM 601686) and PARP4 (MIM 607519), and a nontranslated RNA component, VTRNA1-1 (Kickhoefer et al., 1999 [PubMed 10551828]).[supplied by OMIM, Mar 2009]

GeneCards Summary for VTRNA1-1 Gene

VTRNA1-1 (Vault RNA 1-1) is an RNA Gene, and is affiliated with the vault RNA class.

Additional gene information for VTRNA1-1 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VTRNA1-1 Gene

Genomics for VTRNA1-1 Gene

Regulatory Elements for VTRNA1-1 Gene

Enhancers for VTRNA1-1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05H140112 2.1 ENCODE 14.6 -597.3 -597300 3.6 HDGF ARID4B SIN3A ZNF2 CBX5 ZNF416 ZNF207 SP5 ZHX2 MXD4 HARS2 ANKHD1 WDR55 VTRNA1-1 TMCO6 IK GC05P140117 PIR63019
GH05H139744 1.6 Ensembl ENCODE dbSUPER 14.6 -964.9 -964875 4.7 HDGF PKNOX1 SIN3A FEZF1 DMAP1 YBX1 ZNF2 YY1 ZNF416 ZNF143 HARS2 ANKHD1 WDR55 VTRNA1-1 TMCO6 MALINC1 IK PSD2 PURA LOC101929719
GH05H140399 1.2 ENCODE 14.6 -309.2 -309247 4.7 ZFP64 DMAP1 YY1 ZNF143 SP3 NFYC ZNF610 ZNF585B GLIS1 NBN PURA HARS2 IK ANKHD1 PCDHB18P APBB3 PCDHGA6 SRA1 VTRNA1-1 CD14
GH05H140646 1.1 ENCODE 14.8 -63.7 -63656 2.4 HDGF FOXA2 PKNOX1 ARNT SIN3A DMAP1 ZNF2 YY1 ZNF766 ZNF207 ANKHD1 LOC102723915 HDAC3 WDR55 HARS2 VTRNA1-1 SRA1 TMCO6 CD14 IK
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around VTRNA1-1 on UCSC Golden Path with GeneCards custom track

Promoters for VTRNA1-1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000187819 -175 1401 PKNOX1 FOXA2 ARNT ARID4B SIN3A FEZF1 ZNF2 YY1 ZNF766 ZNF143

Genomic Locations for VTRNA1-1 Gene

Genomic Locations for VTRNA1-1 Gene
99 bases
Plus strand

Genomic View for VTRNA1-1 Gene

Genes around VTRNA1-1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
VTRNA1-1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for VTRNA1-1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VTRNA1-1 Gene

Proteins for VTRNA1-1 Gene

Post-translational modifications for VTRNA1-1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for VTRNA1-1 Gene

Domains & Families for VTRNA1-1 Gene

Gene Families for VTRNA1-1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with VTRNA1-1: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for VTRNA1-1 Gene

Function for VTRNA1-1 Gene

Phenotypes From GWAS Catalog for VTRNA1-1 Gene

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for VTRNA1-1 Gene

Localization for VTRNA1-1 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for VTRNA1-1 Gene

Pathways & Interactions for VTRNA1-1 Gene

SuperPathways for VTRNA1-1 Gene

No Data Available

Interacting Proteins for VTRNA1-1 Gene

Gene Ontology (GO) - Biological Process for VTRNA1-1 Gene


No data available for Pathways by source and SIGNOR curated interactions for VTRNA1-1 Gene

Drugs & Compounds for VTRNA1-1 Gene

No Compound Related Data Available

Transcripts for VTRNA1-1 Gene

mRNA/cDNA for VTRNA1-1 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for VTRNA1-1 Gene

No ASD Table

Relevant External Links for VTRNA1-1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for VTRNA1-1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for VTRNA1-1 Gene

genes like me logo Genes that share expression patterns with VTRNA1-1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for VTRNA1-1 Gene

Orthologs for VTRNA1-1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for VTRNA1-1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia Vault 34
  • 99 (a)
(Bos Taurus)
Mammalia Vault 34
  • 78 (a)
(Monodelphis domestica)
Mammalia Vault 34
  • 56 (a)
(Mus musculus)
Mammalia Vaultrc5 34
  • 50 (a)
(Gallus gallus)
Aves Vault 34
  • 63 (a)
(Anolis carolinensis)
Reptilia Vault 34
  • 57 (a)
(Danio rerio)
Actinopterygii Vault 34 34 34
  • 49 (a)
sea squirt
(Ciona savignyi)
Ascidiacea Vault 34
  • 50 (a)
Species where no ortholog for VTRNA1-1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for VTRNA1-1 Gene

Gene Tree for VTRNA1-1 (if available)
Gene Tree for VTRNA1-1 (if available)

Paralogs for VTRNA1-1 Gene

No data available for Paralogs for VTRNA1-1 Gene

Variants for VTRNA1-1 Gene

Sequence variations from dbSNP and Humsavar for VTRNA1-1 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1000344319 -- 140,711,731(+) ACTTG(A/C)TCATT intron-variant, downstream-variant-500B
rs1001729269 -- 140,711,271(+) GCAAC(C/G)TCCGG upstream-variant-2KB
rs1001781729 -- 140,711,063(+) ACACA(A/C)CTGCG upstream-variant-2KB
rs1002745450 -- 140,709,623(+) AATAG(A/G)TGTTC upstream-variant-2KB
rs1003434823 -- 140,710,744(+) CCAGT(A/G)CACTG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for VTRNA1-1 Gene

Variant ID Type Subtype PubMed ID
nsv830508 CNV loss 17160897
nsv327820 CNV deletion 16902084
esv3570455 CNV loss 25503493
esv2730831 CNV deletion 23290073

Relevant External Links for VTRNA1-1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for VTRNA1-1 Gene

Disorders for VTRNA1-1 Gene

Relevant External Links for VTRNA1-1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for VTRNA1-1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for VTRNA1-1 Gene

Publications for VTRNA1-1 Gene

  1. Epstein-barr virus-induced expression of a novel human vault RNA. (PMID: 19298825) Nandy C … Polacek N (Journal of molecular biology 2009) 2 3 60
  2. Evolution of vault RNAs. (PMID: 19491402) Stadler PF … Ullmann K (Molecular biology and evolution 2009) 2 3 60
  3. Vaults are up-regulated in multidrug-resistant cancer cell lines. (PMID: 9535882) Kickhoefer VA … Rome LH (The Journal of biological chemistry 1998) 2 3 60
  4. The BTB and CNC homology 1 (BACH1) target genes are involved in the oxidative stress response and in control of the cell cycle. (PMID: 21555518) Warnatz HJ … Yaspo ML (The Journal of biological chemistry 2011) 3 60
  5. Vaults and telomerase share a common subunit, TEP1. (PMID: 10551828) Kickhoefer VA … Rome LH (The Journal of biological chemistry 1999) 3 60

Products for VTRNA1-1 Gene

Sources for VTRNA1-1 Gene

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