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Aliases for VTN Gene

Aliases for VTN Gene

  • Vitronectin 2 3 5
  • Serum Spreading Factor 2 3
  • Serum-Spreading Factor 3 4
  • Complement S-Protein 2 3
  • Somatomedin B 2 3
  • S-Protein 3 4
  • V75 3 4
  • VN 3 4
  • Vitronectin (Serum Spreading Factor, Somatomedin B, Complement S-Protein) 2
  • Epibolin 3
  • VNT 3

External Ids for VTN Gene

Previous GeneCards Identifiers for VTN Gene

  • GC17M026549
  • GC17M028594
  • GC17M026839
  • GC17M023718
  • GC17M026692
  • GC17M026753
  • GC17M026890
  • GC17M026991
  • GC17M027137
  • GC17M028368
  • GC17M028457

Summaries for VTN Gene

Entrez Gene Summary for VTN Gene

  • The protein encoded by this gene is a member of the pexin family. It is found in serum and tissues and promotes cell adhesion and spreading, inhibits the membrane-damaging effect of the terminal cytolytic complement pathway, and binds to several serpin serine protease inhibitors. It is a secreted protein and exists in either a single chain form or a clipped, two chain form held together by a disulfide bond. [provided by RefSeq, Jul 2008]

GeneCards Summary for VTN Gene

VTN (Vitronectin) is a Protein Coding gene. Diseases associated with VTN include glanzmann thrombasthenia and lateral sinus thrombosis. Among its related pathways are Complement and coagulation cascades and ECM-receptor interaction. GO annotations related to this gene include heparin binding and scavenger receptor activity. An important paralog of this gene is ENSG00000273171.

UniProtKB/Swiss-Prot for VTN Gene

  • Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway.

  • Somatomedin-B is a growth hormone-dependent serum factor with protease-inhibiting activity.

Gene Wiki entry for VTN Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VTN Gene

Genomics for VTN Gene

Regulatory Elements for VTN Gene

Enhancers for VTN Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around VTN on UCSC Golden Path with GeneCards custom track

Promoters for VTN Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around VTN on UCSC Golden Path with GeneCards custom track

Genomic Location for VTN Gene

Chromosome:
17
Start:
28,367,276 bp from pter
End:
28,373,091 bp from pter
Size:
5,816 bases
Orientation:
Minus strand

Genomic View for VTN Gene

Genes around VTN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
VTN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for VTN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VTN Gene

Proteins for VTN Gene

  • Protein details for VTN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P04004-VTNC_HUMAN
    Recommended name:
    Vitronectin
    Protein Accession:
    P04004
    Secondary Accessions:
    • B2R7G0
    • P01141
    • Q9BSH7

    Protein attributes for VTN Gene

    Size:
    478 amino acids
    Molecular mass:
    54306 Da
    Quaternary structure:
    • Exists in two forms: a single chain 75 kDa form (V75) and a clipped form composed of two chains (65 kDa and 10 kDa) (V65+V10) which are held together by a disulfide bond. Interacts with SERPINE1/PAI1, insulin and C1QBP.

    Three dimensional structures from OCA and Proteopedia for VTN Gene

neXtProt entry for VTN Gene

Proteomics data for VTN Gene at MOPED

Post-translational modifications for VTN Gene

  • It has been suggested that the active SMB domain may be permitted considerable disulfide bond heterogeneity or variability, thus two alternate disulfide patterns based on 3D structures are described with 1 disulfide bond conserved in both.
  • N- and O-glycosylated.
  • Phosphorylation on Thr-69 and Thr-76 favors cell adhesion and spreading.
  • Phosphorylation sites are present in the extracellular medium.
  • Sulfated on 2 tyrosine residues.
  • Glycosylation at Asn 86, Asn 169, and Asn 242
  • Modification sites at PhosphoSitePlus

Other Protein References for VTN Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for VTN Gene

Domains & Families for VTN Gene

Gene Families for VTN Gene

Suggested Antigen Peptide Sequences for VTN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P04004

UniProtKB/Swiss-Prot:

VTNC_HUMAN :
  • The SMB domain mediates interaction with SERPINE1/PAI1. The heparin-binding domain mediates interaction with insulin.
  • Contains 4 hemopexin repeats.
Domain:
  • The SMB domain mediates interaction with SERPINE1/PAI1. The heparin-binding domain mediates interaction with insulin.
  • Contains 1 SMB (somatomedin-B) domain.
Similarity:
  • Contains 4 hemopexin repeats.
genes like me logo Genes that share domains with VTN: view

Function for VTN Gene

Molecular function for VTN Gene

GENATLAS Biochemistry:
vitronectin,complement S protein (75kDa),precursor of 65 and 10kDa chains
UniProtKB/Swiss-Prot Function:
Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway.
UniProtKB/Swiss-Prot Function:
Somatomedin-B is a growth hormone-dependent serum factor with protease-inhibiting activity.

Gene Ontology (GO) - Molecular Function for VTN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005044 scavenger receptor activity IEA --
GO:0005178 integrin binding IPI 8837777
genes like me logo Genes that share ontologies with VTN: view
genes like me logo Genes that share phenotypes with VTN: view

Animal Models for VTN Gene

MGI Knock Outs for VTN:

Animal Model Products

miRNA for VTN Gene

miRTarBase miRNAs that target VTN

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for VTN Gene

Localization for VTN Gene

Subcellular locations from UniProtKB/Swiss-Prot for VTN Gene

Secreted, extracellular space.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for VTN Gene COMPARTMENTS Subcellular localization image for VTN gene
Compartment Confidence
extracellular 5
plasma membrane 5
cytoskeleton 2
cytosol 2
endoplasmic reticulum 2
mitochondrion 2
nucleus 2
chloroplast 1
endosome 1
golgi apparatus 1
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for VTN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0071062 alphav-beta3 integrin-vitronectin complex TAS 19267251
genes like me logo Genes that share ontologies with VTN: view

Pathways & Interactions for VTN Gene

genes like me logo Genes that share pathways with VTN: view

Gene Ontology (GO) - Biological Process for VTN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006898 receptor-mediated endocytosis IEA --
GO:0006955 immune response IEA --
GO:0007155 cell adhesion TAS 2418831
GO:0007160 cell-matrix adhesion IEA,IDA 10022831
GO:0030195 negative regulation of blood coagulation IC 1695900
genes like me logo Genes that share ontologies with VTN: view

No data available for SIGNOR curated interactions for VTN Gene

Drugs & Compounds for VTN Gene

(34) Drugs for VTN Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Abciximab Approved Pharma Target 64

(72) Additional Compounds for VTN Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with VTN: view

Transcripts for VTN Gene

mRNA/cDNA for VTN Gene

Unigene Clusters for VTN Gene

Vitronectin:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for VTN Gene

No ASD Table

Relevant External Links for VTN Gene

GeneLoc Exon Structure for
VTN
ECgene alternative splicing isoforms for
VTN

Expression for VTN Gene

mRNA expression in normal human tissues for VTN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for VTN Gene

This gene is overexpressed in Serum (22.2), Synovial fluid (10.6), and Plasma (10.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for VTN Gene



SOURCE GeneReport for Unigene cluster for VTN Gene Hs.2257

mRNA Expression by UniProt/SwissProt for VTN Gene

P04004-VTNC_HUMAN
Tissue specificity: Plasma.
genes like me logo Genes that share expression patterns with VTN: view

Protein tissue co-expression partners for VTN Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for VTN Gene

Orthologs for VTN Gene

This gene was present in the common ancestor of chordates.

Orthologs for VTN Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia VTN 35
  • 80.71 (n)
  • 72.49 (a)
VTN 36
  • 71 (a)
OneToOne
dog
(Canis familiaris)
Mammalia VTN 35
  • 82.51 (n)
  • 77.52 (a)
VTN 36
  • 74 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Vtn 35
  • 79.38 (n)
  • 75.64 (a)
Vtn 16
Vtn 36
  • 72 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia VTN 35
  • 99.37 (n)
  • 99.37 (a)
VTN 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Vtn 35
  • 77.01 (n)
  • 76.34 (a)
oppossum
(Monodelphis domestica)
Mammalia VTN 36
  • 58 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia VTN 36
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves VTN 35
  • 64.95 (n)
  • 61.74 (a)
VTN 36
  • 57 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia VTN 36
  • 51 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.15366 35
vtn 35
  • 60.67 (n)
  • 58.13 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.9844 35
zebrafish
(Danio rerio)
Actinopterygii Dr.13466 35
vtnb 35
  • 55.89 (n)
  • 53.03 (a)
vtna 36
  • 41 (a)
OneToMany
vtnb 36
  • 44 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11199 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 32 (a)
OneToMany
Species with no ortholog for VTN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for VTN Gene

ENSEMBL:
Gene Tree for VTN (if available)
TreeFam:
Gene Tree for VTN (if available)

Paralogs for VTN Gene

Paralogs for VTN Gene

(3) SIMAP similar genes for VTN Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with VTN: view

Variants for VTN Gene

Sequence variations from dbSNP and Humsavar for VTN Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
VAR_012983 -
rs2227723 - 28,368,895(-) TGGCC(A/G)GGAGC reference, missense
rs704 - 28,367,840(-) CGCCA(C/T)GTGGC reference, missense
rs916657 -- 28,367,869(-) CGCAA(C/T)CAGAA reference, synonymous-codon
rs2227722 -- 28,369,055(-) CCATA(C/T)CCCTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for VTN Gene

Variant ID Type Subtype PubMed ID
nsv519388 CNV Loss 19592680

Variation tolerance for VTN Gene

Residual Variation Intolerance Score: 40.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.84; 34.48% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for VTN Gene

HapMap Linkage Disequilibrium report
VTN
Human Gene Mutation Database (HGMD)
VTN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VTN Gene

Disorders for VTN Gene

MalaCards: The human disease database

(19) MalaCards diseases for VTN Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
glanzmann thrombasthenia
  • glanzmann's thrombasthenia
lateral sinus thrombosis
  • thrombosis of lateral venous sinus
camptodactyly-arthropathy-coxa vara-pericarditis syndrome
  • cdags syndrome
thrombasthenia
hemorrhagic fever with renal syndrome
  • hemorrhagic fever, russian
- elite association - COSMIC cancer census association via MalaCards
Search VTN in MalaCards View complete list of genes associated with diseases

Relevant External Links for VTN

Genetic Association Database (GAD)
VTN
Human Genome Epidemiology (HuGE) Navigator
VTN
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
VTN
genes like me logo Genes that share disorders with VTN: view

No data available for UniProtKB/Swiss-Prot and Genatlas for VTN Gene

Publications for VTN Gene

  1. Nucleotide sequence and organization of the human S-protein gene: repeating peptide motifs in the 'pexin' family and a model for their evolution. (PMID: 2447940) Jenne D.E. … Stanley K.K. (Biochemistry 1987) 2 3 4 67
  2. Neisseria meningitidis Opc invasin binds to the sulphated tyrosines of activated vitronectin to attach to and invade human brain endothelial cells. (PMID: 20502634) Sa E Cunha C. … Virji M. (PLoS Pathog. 2010) 3 23
  3. Integrin-linked kinase is required for vitronectin-mediated internalization of Streptococcus pneumoniae by host cells. (PMID: 19118218) Bergmann S. … Hammerschmidt S. (J. Cell. Sci. 2009) 3 23
  4. Vitronectin promotes oligodendrocyte differentiation during neurogenesis of human embryonic stem cells. (PMID: 19162023) Gil J.E. … Kim J.H. (FEBS Lett. 2009) 3 23
  5. Vitronectin concentrations predict risk in patients undergoing coronary stenting. (PMID: 20031688) Derer W. … Dechend R. (Circ Cardiovasc Interv 2009) 3 23

Products for VTN Gene

Sources for VTN Gene

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