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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

VTN Gene

protein-coding   GIFtS: 66
GCID: GC17M026991

Vitronectin

(Previous names: vitronectin (serum spreading factor, somatomedin B, complement...)
Microbiology & Infectious Diseases Congress
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at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
vitronectin1 2     V752 3
Complement S-Protein1 2     VN2 3
Serum Spreading Factor1 2     VNT2 5
Somatomedin B1 2     Vitronectin (Serum Spreading Factor, Somatomedin B, Complement S-Protein)1
Serum-Spreading Factor2 3     epibolin2
S-protein2 3     

External Ids:    HGNC: 127241   Entrez Gene: 74482   Ensembl: ENSG000002720997   OMIM: 1931905   UniProtKB: P040043   

Export aliases for VTN gene to outside databases

Previous GC identifers: GC17M026549 GC17M028594 GC17M026839 GC17M023718 GC17M026692 GC17M026753 GC17M026890


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for VTN Gene:
The protein encoded by this gene is a member of the pexin family. It is found in serum and tissues and promotes
cell adhesion and spreading, inhibits the membrane-damaging effect of the terminal cytolytic complement pathway,
and binds to several serpin serine protease inhibitors. It is a secreted protein and exists in either a single
chain form or a clipped, two chain form held together by a disulfide bond. (provided by RefSeq, Jul 2008)

GeneCards Summary for VTN Gene: 
VTN (vitronectin) is a protein-coding gene. Diseases associated with VTN include camptodactyly arthropathy coxa vara pericarditis syndrome, and congenital nephrotic syndrome finnish type, and among its related super-pathways are ECM-receptor interaction and Focal Adhesion. GO annotations related to this gene include heparin binding and scavenger receptor activity. An important paralog of this gene is PRG4.

UniProtKB/Swiss-Prot: VTNC_HUMAN, P04004
Function: Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact
with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as
a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic
complement pathway
Function: Somatomedin-B is a growth hormone-dependent serum factor with protease-inhibiting activity

Gene Wiki entry for VTN (Vitronectin) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.2  NT_010799.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the VTN gene promoter:
         HTF   p300   NRSF form 1   NF-kappaB   NRSF form 2   GATA-2   ARP-1   NF-kappaB1   LyF-1   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): VTN promoter sequence
   Search SABiosciences Chromatin IP Primers for VTN

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat VTN


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q11   Ensembl cytogenetic band:  17q11.2   HGNC cytogenetic band: 17q11.2

VTN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
VTN gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M026991:  view genomic region     (about GC identifiers)

Start:
26,694,297 bp from pter      End:
26,700,110 bp from pter
Size:
5,814 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: VTNC_HUMAN, P04004 (See protein sequence)
Recommended Name: Vitronectin precursor  
Size: 478 amino acids; 54306 Da
Subunit: Exists in two forms: a single chain 75 kDa form (V75) and a clipped form composed of two chains (65 kDa
and 10 kDa) (V65+V10) which are held together by a disulfide bond. Interacts with SERPINE1/PAI1, insulin and
C1QBP
Subcellular location: Secreted, extracellular space
6 PDB 3D structures from and Proteopedia for VTN:
1OC0 (3D)        1S4G (3D)        1SSU (3D)        2JQ8 (3D)        3BT1 (3D)        3BT2 (3D)    
Secondary accessions: B2R7G0 P01141 Q9BSH7

Explore the universe of human proteins at neXtProt for VTN: NX_P04004

Explore proteomics data for VTN at MOPED 

Post-translational modifications:

  • UniProtKB: Sulfated on 2 tyrosine residues
  • UniProtKB: N- and O-glycosylated (By similarity)
  • UniProtKB: Phosphorylation on Thr-69 and Thr-76 favors cell adhesion and spreading
  • UniProtKB: It has been suggested that the active SMB domain may be permitted considerable disulfide bond heterogeneity or
    variability, thus two alternate disulfide patterns based on 3D structures are described with 1 disulfide bond
    conserved in both
  • UniProtKB: Phosphorylation sites are present in the extracellular medium
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P04004

  • VTN Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    VTN Protein Expression
    REFSEQ proteins: NP_000629.3  
    ENSEMBL proteins: 
     ENSP00000226218   ENSP00000440439  
    Reactome Protein details: P04004
    Human Recombinant Protein Products for VTN: 
    EMD Millipore Purified and/or Recombinant VTN Protein
    R&D Systems Recombinant & Natural Proteins for VTN (Vitronectin)
    Browse recombinant and purified proteins available from Enzo Life Sciences
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    Novus Biologicals VTN Proteins
    Novus Biologicals VTN Lysates
    Sino Biological Recombinant Protein for VTN
    Sino Biological Cell Lysate for VTN 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for VTN 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005578proteinaceous extracellular matrix IEA--
    GO:0005615extracellular space IDA1695900
    GO:0031012colocalizes with extracellular matrix ISS--
    GO:0071062alphav-beta3 integrin-vitronectin complex TAS19267251

    VTN for ontologies           About GeneDecksing



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    Abcam antibodies for VTN
    Cloud-Clone Corp. Antibodies for VTN 
    ThermoFisher Antibody for VTN
    LSBio Antibodies in human, mouse, rat for VTN 

    Assay Products for VTN: 
    EMD Millipore Kits and Assays for the Analysis of VTN
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for VTN
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for VTN 
    Cloud-Clone Corp. CLIAs for VTN


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5 InterPro protein domains:
     IPR000585 Hemopexin-like_dom
     IPR018486 Hemopexin_CS
     IPR018487 Hemopexin-like_repeat
     IPR020436 Somatomedin_B_chordata
     IPR001212 Somatomedin_B_dom

    Graphical View of Domain Structure for InterPro Entry P04004

    ProtoNet protein and cluster: P04004

    1 Blocks protein domain: IPB001212 Somatomedin B

    UniProtKB/Swiss-Prot: VTNC_HUMAN, P04004
    Domain: The SMB domain mediates interaction with SERPINE1/PAI1. The heparin-binding domain mediates interaction
    with insulin
    Similarity: Contains 4 hemopexin repeats
    Similarity: Contains 1 SMB (somatomedin-B) domain


    VTN for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: VTNC_HUMAN, P04004
    Function: Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact
    with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as
    a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic
    complement pathway
    Function: Somatomedin-B is a growth hormone-dependent serum factor with protease-inhibiting activity

         Genatlas biochemistry entry for VTN:
    vitronectin,complement S protein (75kDa),precursor of 65 and 10kDa chains

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005044scavenger receptor activity IEA--
    GO:0005178integrin binding IPI8837777
    GO:0005515protein binding IPI8900153
    GO:0008201heparin binding IEA--
    GO:0030247polysaccharide binding IEA--
         
    VTN for ontologies           About GeneDecksing


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Vtn):
     hematopoietic system  homeostasis/metabolism  normal 

    VTN for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Vtntm1Dgi for VTN

       inGenious Targeting Laboratory - Custom generated mouse model solutions for VTN 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for VTN

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for VTN 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for VTN 

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    GenScript: all cDNA clones in your preferred vector: VTN (NM_000638)
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for VTN
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VTN
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                         Customized lentivirus expression plasmids for stable overexpression of VTN 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VTN


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for VTN About   (see all 23)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Non-integrin membrane-ECM interactions
    Non-integrin membrane-ECM interactions0.44
    ECM proteoglycans0.38
    Syndecan interactions0.44
    Integrin cell surface interactions0.32
    ECM-receptor interaction0.42
    2Focal Adhesion
    Focal Adhesion0.64
    Focal adhesion0.64
    3Elastic fibre formation
    Elastic fibre formation0.84
    Molecules associated with elastic fibres0.84
    4Immune System
    Immune System0.56
    Innate Immune System0.50
    5Classical antibody-mediated complement activation
    Complement cascade0.76

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5 EMD Millipore Pathways for VTN
        Cytoskeleton remodeling Integrin outside-in signaling
    Development VEGF-family signaling
    Cell adhesion PLAU signaling
    Cell adhesion ECM remodeling
    Cell adhesion Endothelial cell contacts by non-junctional mechanisms

    3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for VTN
        Glioma Invasiveness
    UPA-UPAR Pathway
    Phagocytosis of Microbes

    5 GeneGo (Thomson Reuters) Pathways for VTN
        Development VEGF-family signaling
    Cell adhesion Endothelial cell contacts by non-junctional mechanisms
    Cytoskeleton remodeling Integrin outside-in signaling
    Cell adhesion PLAU signaling
    Cell adhesion ECM remodeling

    5/6 BioSystems Pathways for VTN (see all 6)
        Focal Adhesion
    Senescence and Autophagy
    Integrins in angiogenesis
    amb2 Integrin signaling
    FOXA1 transcription factor network


    5/12        Reactome Pathways for VTN (see all 12)
        Integrin cell surface interactions
    Elastic fibre formation
    ECM proteoglycans
    Molecules associated with elastic fibres
    Extracellular matrix organization


    4         Kegg Pathways  (Kegg details for VTN):
        PI3K-Akt signaling pathway
    Focal adhesion
    ECM-receptor interaction
    Proteoglycans in cancer


    VTN for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for VTN

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/78 Interacting proteins for VTN (P040041, 2, 3 ENSP000002262184) via UniProtKB, MINT, STRING, and/or I2D (see all 78)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SERPINE1P051212, 3, ENSP000002230954MINT-24884 I2D: score=4 STRING: ENSP00000223095
    PASKQ96RG22, 3, ENSP000002340404MINT-8148755 I2D: score=1 STRING: ENSP00000234040
    COPS5Q929053, ENSP000003505124I2D: score=2 STRING: ENSP00000350512
    GEMP550403, ENSP000002975964I2D: score=2 STRING: ENSP00000297596
    IGFBP5P245933, ENSP000002338134I2D: score=2 STRING: ENSP00000233813
    About this table

    Gene Ontology (GO): 5/17 biological process terms (GO ID links to tree view) (see all 17):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006955immune response TAS2418831
    GO:0007155cell adhesion TAS2418831
    GO:0007160cell-matrix adhesion IDA10022831
    GO:0010811positive regulation of cell-substrate adhesion IEA--
    GO:0010951negative regulation of endopeptidase activity IDA1695900

    VTN for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    VTN for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for VTN (VTNC)

    1 DrugBank Compound for VTN    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Abciximab7E3 (see all 4)143653-53-6target--12749745 17160551

    10/106 Novoseek inferred chemical compound relationships for VTN gene (see all 106)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lm 609 85.3 11 18331351 (2), 1703545 (1), 1383272 (1), 11249574 (1) (see all 8)
    grgds 83.2 14 7689480 (2), 7542937 (1), 8972713 (1), 1281631 (1) (see all 13)
    echistatin 80.6 21 8635506 (3), 9353406 (2), 7615123 (2), 7687129 (2) (see all 12)
    fibrinogen 80.2 333 1708387 (7), 1717474 (5), 7545129 (5), 1707057 (5) (see all 99)
    grgdsp 77.8 9 8486712 (1), 10563507 (1), 8761939 (1), 1382615 (1) (see all 8)
    grgdspk 69.8 2 9120775 (1), 9426454 (1)
    heparin 66 268 10037735 (8), 1708387 (7), 11437360 (7), 10545182 (6) (see all 97)
    barbourin 63.7 1 8635506 (1)
    matrigel 62 23 9177878 (2), 8634137 (2), 18599809 (2), 11369141 (1) (see all 20)
    eristostatin 61.2 2 8706902 (1), 8635506 (1)

    Search CenterWatch for drugs/clinical trials and news about VTN / VTNC

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for VTN gene: 
    NM_000638.3  

    Unigene Cluster for VTN:

    Vitronectin
    Hs.2257  [show with all ESTs]
    Unigene Representative Sequence: AK298441
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000226218(uc002hbc.3) ENST00000539746 ENST00000542029
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Additional mRNA sequence: 

    AK298441.1 AK312968.1 BC005046.1 X03168.1 

    15 DOTS entries:

    DT.454116  DT.100885455  DT.100885459  DT.91753762  DT.100885454  DT.100885466  DT.319122  DT.100885475 
    DT.40240655  DT.91753757  DT.86854853  DT.95326649  DT.100885458  DT.91753753  DT.91753755 

    24/411 AceView cDNA sequences (see all 411):

    CR619430 CR615837 T28597 BX448138 CR593802 H94112 BU164632 BU541932 
    CB146949 BQ957084 CR616555 CB124827 AV647187 AL540697 CB141723 CB115667 
    CR592778 CR601125 BE221615 CR601563 CR620941 AV658551 CR615135 BX380761 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    VTN expression in normal human tissues (normalized intensities)      VTN embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCGGGCCCT
    VTN Expression
    About this image


    VTN expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/17 selected tissues (see all 17) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 9 entries
             Endochondral Osteocytes Zeugopod Periosteum
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Floor Plate Cells Spinal Floor Plate
             Metencephalon
     
     Liver (Hepatobiliary System)    fully expand to see all 2 entries
             Liver Lobule
             Human Hepatocyte (HH)   
     
     Primitive Streak (Early Embryonic Tissues)    fully expand to see all 2 entries
             Notochord Cells Notochord
             Notochord
     
     Pancreas (Endocrine System)    fully expand to see all 2 entries
             Pancreatic endoderm/endocrine precursor-like cells ( A scalable, suspension protocol...
             visceral organ/gut/foregut-midgut junction   

    See VTN Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for VTN

    SOURCE GeneReport for Unigene cluster: Hs.2257

    UniProtKB/Swiss-Prot: VTNC_HUMAN, P04004
    Tissue specificity: Plasma

        SABiosciences Expression via Pathway-Focused PCR Arrays including VTN: 
              Extracellular Matrix & Adhesion Molecules in human mouse rat
              Wound Healing in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VTN

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for VTN gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Vtn1 , 5 vitronectin1, 5 79.48(n)1
    75.8(a)1
      11 (46.74 cM)5
    223701  NM_011707.21  NP_035837.11 
     784990915 
    chicken
    (Gallus gallus)
    Aves VTN1 vitronectin 64.64(n)
    61.35(a)
      395935  NM_205061.1  NP_990392.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.98442 Xenopus laevis transcribed sequence with weak similarity more 75.03(n)    CF547304.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.134662 Danio rerio cDNA clone IMAGE5409846, partial cds 71.23(n)    BC055570.1 


    ENSEMBL Gene Tree for VTN (if available)
    TreeFam Gene Tree for VTN (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for VTN gene
    PRG42  
    1 SIMAP similar gene for VTN using alignment to 2 protein entries:     VTNC_HUMAN (see all proteins):
    SEBOX

    VTN for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/134 SNPs in VTN are shown (see all 134)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs22277291,2
    C,F,A,H--26694296(-) TAAAAT/CTATTG 1 -- ds500121Minor allele frequency- C:0.16NS EA NA CSA WA 3014
    rs776792591,2
    C--26694329(+) ATTGGG/ACTGGG 1 -- ut313Minor allele frequency- A:0.01CSA NS WA 655
    rs1502413351,2
    F--26694432(+) TGAGCG/AATGGA 2 /I syn11Minor allele frequency- A:0.00NA 4540
    rs1413686341,2
    C--26694460(+) CCACAA/GTGTCC 2 T I mis10--------
    rs22277281,2
    C,F,O,A,H--26694483(-) GTCAAT/CCTTCG 2 /N syn128Minor allele frequency- C:0.12NS NA EA CSA WA EU 9008
    rs1437890071,2
    C--26694484(+) GAAGAC/TTGACT 2 N S mis10--------
    rs22277271,2
    C,F--26694528(-) CTCACG/ACATCC 1 -- int15Minor allele frequency- A:0.02NS WA 750
    rs1512866721,2
    C--26694529(+) GATGCA/GTGAGG 1 -- int10--------
    rs1404743031,2
    --26694575(+) TCTAGA/GGTCTC 1 -- int10--------
    rs22277261,2
    C,F,A,H--26694661(-) CTGAAC/TGCAGC 1 -- int17Minor allele frequency- T:0.17NS NA CSA WA EA 459

    HapMap Linkage Disequilibrium report for VTN (26694297 - 26700110 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for VTN:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv519388CNV Loss19592680


    Human Gene Mutation Database (HGMD): VTN
    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing VTN
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 193190    OMIM disorders: --

    20/96 diseases for VTN (see all 96):    About MalaCards
    camptodactyly arthropathy coxa vara pericarditis syndrome    congenital nephrotic syndrome finnish type    colonic disease    mastitis
    thrombasthenia    diabetic retinopathy    proliferative diabetic retinopathy    glanzmann's thrombasthenia
    hemorrhagic fever with renal syndrome    pericarditis    proliferative vitreoretinopathy    nephrotic syndrome
    fibrosarcoma    arthropathy    dermatomyositis    disseminated intravascular coagulation
    mouth disease    differentiating neuroblastoma    hemangioblastoma    interstitial lung disease


    VTN for disorders           About GeneDecksing

    10/92 Novoseek inferred disease relationships for VTN gene (see all 92)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glanzmann thrombasthenia 56.3 3 9361020 (1), 1726706 (1)
    drusen 55.6 28 10064614 (4), 10329419 (4), 11846519 (2), 10783137 (2) (see all 13)
    metastasis 48.4 17 12447999 (2), 7694604 (1), 11988838 (1), 15493875 (1) (see all 13)
    melanoma 47.2 40 9096674 (4), 7545129 (3), 10428859 (1), 8423675 (1) (see all 32)
    tumors 42.3 102 10389948 (4), 11433393 (4), 1721625 (3), 8751559 (3) (see all 54)
    neovascularization 35.9 3 15596522 (2), 12766088 (1)
    vitreoretinopathy proliferative 33.7 11 1694159 (2), 7514582 (2), 1708748 (1), 1698696 (1) (see all 6)
    glioma 32.3 38 10389948 (4), 7749720 (4), 17886558 (4), 7543163 (3) (see all 17)
    osteosarcoma 30.3 8 16569238 (2), 16897174 (1), 1712876 (1), 16012763 (1) (see all 6)
    fibrosarcoma 28.8 10 9164658 (3), 16052409 (2), 7521757 (1), 12447999 (1)

    Genetic Association Database (GAD): VTN
    Human Genome Epidemiology (HuGE) Navigator: VTN (8 documents)

    Export disorders for VTN gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for VTN gene, integrated from 9 sources (see all 1113):
    (articles sorted by number of sources associating them with VTN)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Nucleotide sequence and organization of the human S-protein gene: repeating peptide motifs in the 'pexin' family and a model for their evolution. (PubMed id 2447940)1, 2, 3 Jenne D.E. and Stanley K.K. (1987)
    2. Phosphorylation of vitronectin by casein kinase II. Identification of the sites and their promotion of cell adhesion and spreading. (PubMed id 9733784)1, 2, 9 Seger D.... Shaltiel S. (1998)
    3. Identification of a PAI-1 binding site in vitronectin. (PubMed id 7522053)1, 2, 9 Sigurdardottir O. and Wiman B. (1994)
    4. Evidence that type 1 plasminogen activator inhibitor binds to the somatomedin B domain of vitronectin. (PubMed id 1704366)1, 2, 9 Seiffert D. and Loskutoff D.J. (1991)
    5. How vitronectin binds PAI-1 to modulate fibrinolysis and cell migration. (PubMed id 12808446)1, 2, 9 Zhou A.... Read R.J. (2003)
    6. The phosphorylation of the two-chain form of vitronectin by protein kinase A is heparin dependent. (PubMed id 1696913)1, 2, 9 Chain D.... Shaltiel S. (1990)
    7. The binding protein for globular heads of complement C1q, gC1qR. Functional expression and characterization as a novel vitronectin binding factor. (PubMed id 8900153)1, 2, 9 Lim B.L....Preissner K.T. (1996)
    8. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    9. The variant rs1867277 in FOXE1 gene confers thyroid c ancer susceptibility through the recruitment of USF1/USF2 transcription factors . (PubMed id 19730683)1, 4 Landa I....Robledo M. (2009)
    10. Association between the SERPING1 gene and age-related macular degeneration: a two-stage case-control study. (PubMed id 18842294)1, 4 Ennis S....Lotery A. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7448 HGNC: 12724 AceView: VTN Ensembl:ENSG00000272099 euGenes: HUgn7448
    ECgene: VTN Kegg: 7448 H-InvDB: VTN

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for VTN Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for VTN Genetics and Cytogenetics in Oncology and Haematology
    SeattleSNPshttp://pga.gs.washington.edu/data/vtn/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for VTN gene:
    Search GeneIP for patents involving VTN

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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