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VTN Gene

protein-coding   GIFtS: 68
GCID: GC17M027137

Vitronectin

(Previous names: vitronectin (serum spreading factor, somatomedin B, complement...)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
vitronectin1 2     V752 3
Complement S-Protein1 2     VN2 3
Serum Spreading Factor1 2     VNT2 5
Somatomedin B1 2     Vitronectin (Serum Spreading Factor, Somatomedin B, Complement S-Protein)1
Serum-Spreading Factor2 3     epibolin2
S-protein2 3     

External Ids:    HGNC: 127241   Entrez Gene: 74482   Ensembl: ENSG000001090727   OMIM: 1931905   UniProtKB: P040043   

Export aliases for VTN gene to outside databases

Previous GC identifers: GC17M026549 GC17M028594 GC17M026839 GC17M023718 GC17M026692 GC17M026753 GC17M026890 GC17M026991


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for VTN Gene:
The protein encoded by this gene is a member of the pexin family. It is found in serum and tissues and promotes
cell adhesion and spreading, inhibits the membrane-damaging effect of the terminal cytolytic complement pathway,
and binds to several serpin serine protease inhibitors. It is a secreted protein and exists in either a single
chain form or a clipped, two chain form held together by a disulfide bond. (provided by RefSeq, Jul 2008)

GeneCards Summary for VTN Gene:
VTN (vitronectin) is a protein-coding gene. Diseases associated with VTN include colonic disease, and camptodactyly arthropathy coxa vara pericarditis syndrome. GO annotations related to this gene include heparin binding and scavenger receptor activity. An important paralog of this gene is PRG4.

UniProtKB/Swiss-Prot: VTNC_HUMAN, P04004
Function: Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact
with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as
a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic
complement pathway
Function: Somatomedin-B is a growth hormone-dependent serum factor with protease-inhibiting activity

Gene Wiki entry for VTN (Vitronectin) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000017.11  NC_018928.2  NT_010783.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the VTN gene promoter:
         HTF   p300   NRSF form 1   NF-kappaB   NRSF form 2   GATA-2   ARP-1   NF-kappaB1   LyF-1   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): VTN promoter sequence
   Search Chromatin IP Primers for VTN

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat VTN


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q11   Ensembl cytogenetic band:  17q11.2   HGNC cytogenetic band: 17q11.2

VTN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
VTN gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M027137:  view genomic region     (about GC identifiers)

Start:
26,691,290 bp from pter      End:
26,700,110 bp from pter
Size:
8,821 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: VTNC_HUMAN, P04004 (See protein sequence)
Recommended Name: Vitronectin precursor  
Size: 478 amino acids; 54306 Da
Subunit: Exists in two forms: a single chain 75 kDa form (V75) and a clipped form composed of two chains (65 kDa
and 10 kDa) (V65+V10) which are held together by a disulfide bond. Interacts with SERPINE1/PAI1, insulin and
C1QBP
6 PDB 3D structures from and Proteopedia for VTN:
1OC0 (3D)        1S4G (3D)        1SSU (3D)        2JQ8 (3D)        3BT1 (3D)        3BT2 (3D)    
Secondary accessions: B2R7G0 P01141 Q9BSH7

Explore the universe of human proteins at neXtProt for VTN: NX_P04004

Explore proteomics data for VTN at MOPED

Post-translational modifications: 

  • Sulfated on 2 tyrosine residues1
  • N- and O-glycosylated (By similarity)1
  • Phosphorylation on Thr-69 and Thr-76 favors cell adhesion and spreading1
  • It has been suggested that the active SMB domain may be permitted considerable disulfide bond heterogeneity or
    variability, thus two alternate disulfide patterns based on 3D structures are described with 1 disulfide bond
    conserved in both1
  • Phosphorylation sites are present in the extracellular medium1
  • Glycosylation2 at Asn86, Asn169, Asn242
  • Modification sites at PhosphoSitePlus

  • See VTN Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000629.3  
    ENSEMBL proteins: 
     ENSP00000226218   ENSP00000440439   ENSP00000444503   ENSP00000395142   ENSP00000416240  
    Reactome Protein details: P04004

    VTN Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant VTN Protein
    R&D Systems Recombinant & Natural Proteins for VTN (Vitronectin)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for VTN
    OriGene Protein Over-expression Lysate for VTN
    OriGene MassSpec for VTN
    OriGene Custom Protein Services for VTN
    GenScript Custom Purified and Recombinant Proteins Services for VTN
    Novus Biologicals VTN Proteins
    Novus Biologicals VTN Lysates
    Sino Biological Recombinant Protein for VTN
    Sino Biological Cell Lysate for VTN
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for VTN

    VTN Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of VTN
    R&D Systems Antibodies for VTN (Vitronectin)
    OriGene Antibodies for VTN
    OriGene Custom Antibody Services for VTN
    Novus Biologicals VTN Antibodies
    Abcam antibodies for VTN
    Cloud-Clone Corp. Antibodies for VTN
    ThermoFisher Antibody for VTN
    LSBio Antibodies in human, mouse, rat for VTN

    VTN Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for VTN
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for VTN
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for VTN
    Cloud-Clone Corp. CLIAs for VTN


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ENDOLIG: Endogenous ligands

    5 InterPro protein domains:
     IPR000585 Hemopexin-like_dom
     IPR018486 Hemopexin_CS
     IPR018487 Hemopexin-like_repeat
     IPR001212 Somatomedin_B_dom
     IPR020436 Somatomedin_B_chordata

    Graphical View of Domain Structure for InterPro Entry P04004

    ProtoNet protein and cluster: P04004

    1 Blocks protein domain: IPB001212 Somatomedin B

    UniProtKB/Swiss-Prot: VTNC_HUMAN, P04004
    Domain: The SMB domain mediates interaction with SERPINE1/PAI1. The heparin-binding domain mediates interaction
    with insulin
    Similarity: Contains 4 hemopexin repeats
    Similarity: Contains 1 SMB (somatomedin-B) domain


    VTN for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: VTNC_HUMAN, P04004
    Function: Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact
    with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as
    a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic
    complement pathway
    Function: Somatomedin-B is a growth hormone-dependent serum factor with protease-inhibiting activity

         Genatlas biochemistry entry for VTN:
    vitronectin,complement S protein (75kDa),precursor of 65 and 10kDa chains

         Gene Ontology (GO): Selected molecular function terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ----
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity ----
    GO:0005044scavenger receptor activity IEA--
    GO:0005178integrin binding IPI8837777
         
    VTN for ontologies           About GeneDecksing


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Vtn):
     hematopoietic system  homeostasis/metabolism  normal 

    VTN for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Vtntm1Dgi for VTN

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for VTN
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for VTN

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for VTN
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for VTN

    miRNA
    Products:
        
    miRTarBase miRNAs that target VTN:
    hsa-mir-335-5p (MIRT018592), hsa-mir-26b-5p (MIRT029971)

    Block miRNA regulation of human, mouse, rat VTN using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate VTN
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for VTN
    Predesigned siRNA for gene silencing in human, mouse, rat VTN

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for VTN

    Clone
    Products:
         
    OriGene clones in human, mouse for VTN (see all 6)
    OriGene ORF clones in mouse, rat for VTN
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: VTN (NM_000638)
    Sino Biological Human cDNA Clone for VTN
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for VTN
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VTN

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for VTN
    Browse ESI BIO Cell Lines and PureStem Progenitors for VTN 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VTN


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    VTNC_HUMAN, P04004: Secreted, extracellular space

    Gene Ontology (GO): Selected cellular component terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ----
    GO:0005576extracellular region TAS--
    GO:0005578proteinaceous extracellular matrix IEA--
    GO:0005615extracellular space IDA1695900
    GO:0005634nucleus ----

    VTN for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for VTN About   (see all 23)  
    See pathways by source

    SuperPathContained pathways About
    1Focal adhesion
    Focal adhesion0.65
    ECM-receptor interaction0.31
    Focal Adhesion0.65
    2Elastic fibre formation
    Elastic fibre formation0.73
    Molecules associated with elastic fibres0.73
    3Non-integrin membrane-ECM interactions
    Non-integrin membrane-ECM interactions0.35
    Syndecan interactions0.00
    4Creation of C4 and C2 activators
    Complement cascade0.68
    5Apoptotic Pathways in Synovial Fibroblasts
    Glioma Invasiveness0.64

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for VTN
        Glioma Invasiveness
    UPA-UPAR Pathway
    Phagocytosis of Microbes

    5 GeneGo (Thomson Reuters) Pathways for VTN
        Development VEGF-family signaling
    Cell adhesion Endothelial cell contacts by non-junctional mechanisms
    Cytoskeleton remodeling Integrin outside-in signaling
    Cell adhesion PLAU signaling
    Cell adhesion ECM remodeling

    Selected BioSystems Pathways for VTN (see all 6)
        Focal Adhesion
    Senescence and Autophagy
    amb2 Integrin signaling
    FOXA1 transcription factor network
    Integrins in angiogenesis


    5 Reactome Pathways for VTN
        Molecules associated with elastic fibres
    ECM proteoglycans
    Integrin cell surface interactions
    Regulation of Complement cascade
    Syndecan interactions


    4 Kegg Pathways  (Kegg details for VTN):
        PI3K-Akt signaling pathway
    Focal adhesion
    ECM-receptor interaction
    Proteoglycans in cancer


    VTN for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including VTN: 
              Extracellular Matrix & Adhesion Molecules in human mouse rat
              Wound Healing in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for VTN

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for VTN (P040041, 2, 3 ENSP000002262184) via UniProtKB, MINT, STRING, and/or I2D (see all 79)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SERPINE1P051212, 3, ENSP000002230954MINT-24884 I2D: score=4 STRING: ENSP00000223095
    PASKQ96RG22, 3, ENSP000002340404MINT-8148755 I2D: score=1 STRING: ENSP00000234040
    COPS5Q929053, ENSP000003505124I2D: score=2 STRING: ENSP00000350512
    GEMP550403, ENSP000002975964I2D: score=2 STRING: ENSP00000297596
    IGFBP5P245933, ENSP000002338134I2D: score=2 STRING: ENSP00000233813
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 22):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated ----
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0006955immune response TAS2418831
    GO:0007155cell adhesion TAS2418831
    GO:0007160cell-matrix adhesion IDA10022831

    VTN for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for VTN (VTNC)

    1 DrugBank Compound for VTN    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Abciximab7E3 (see all 4)143653-53-6target--12749745 17160551

    Selected Novoseek inferred chemical compound relationships for VTN gene (see all 106)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lm 609 85.3 11 18331351 (2), 1703545 (1), 1383272 (1), 11249574 (1) (see all 8)
    grgds 83.2 14 7689480 (2), 7542937 (1), 8972713 (1), 1281631 (1) (see all 13)
    echistatin 80.6 21 8635506 (3), 9353406 (2), 7615123 (2), 7687129 (2) (see all 12)
    fibrinogen 80.2 333 1708387 (7), 1717474 (5), 7545129 (5), 1707057 (5) (see all 99)
    grgdsp 77.8 9 8486712 (1), 10563507 (1), 8761939 (1), 1382615 (1) (see all 8)
    grgdspk 69.8 2 9120775 (1), 9426454 (1)
    heparin 66 268 10037735 (8), 1708387 (7), 11437360 (7), 10545182 (6) (see all 97)
    barbourin 63.7 1 8635506 (1)
    matrigel 62 23 9177878 (2), 8634137 (2), 18599809 (2), 11369141 (1) (see all 20)
    eristostatin 61.2 2 8706902 (1), 8635506 (1)



    VTN for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for VTN gene: 
    NM_000638.3  

    Unigene Cluster for VTN:

    Vitronectin
    Hs.2257  [show with all ESTs]
    Unigene Representative Sequence: AK298441
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000226218(uc002hbc.3) ENST00000539746 ENST00000542029 ENST00000536498
    ENST00000438614 ENST00000431468(uc010wai.1)
    miRNA
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    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat VTN
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    GenScript: all cDNA clones in your preferred vector: VTN (NM_000638)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for VTN
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VTN
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for VTN
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat VTN
      QuantiTect SYBR Green Assays in human, mouse, rat VTN
      QuantiFast Probe-based Assays in human, mouse, rat VTN

    Additional mRNA sequence: 

    AK298441.1 AK312968.1 BC005046.1 X03168.1 

    15 DOTS entries:

    DT.454116  DT.100885455  DT.100885459  DT.91753762  DT.100885454  DT.100885466  DT.319122  DT.100885475 
    DT.40240655  DT.91753757  DT.86854853  DT.95326649  DT.100885458  DT.91753753  DT.91753755 

    Selected AceView cDNA sequences (see all 411):

    CR608327 CB146958 CB114897 CR590168 CR620941 CR592341 T28597 CR615837 
    CR593802 CR622872 BU164632 CR621228 CB115667 CR619020 CR616555 BX380761 
    CA397800 H94112 CA390457 AL532020 CR593593 CR625072 BX346210 CB141697 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    VTN expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCGGGCCCT
    VTN Expression
    About this image


    VTN expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 16) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 9 entries
             Endochondral Osteocytes Zeugopod Periosteum
     
     Heart (Cardiovascular System)    fully expand to see all 2 entries
             Subepicardial Cells Epicardium
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Floor Plate Cells Spinal Floor Plate
             Metencephalon
     
     Liver (Hepatobiliary System)    fully expand to see all 2 entries
             Liver Lobule
             Hepatocyte-like cells
     
     Primitive Streak (Early Embryonic Tissues)    fully expand to see all 2 entries
             Notochord Cells Notochord
             Notochord
    VTN Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    VTN Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.2257

    UniProtKB/Swiss-Prot: VTNC_HUMAN, P04004
    Tissue specificity: Plasma

        Pathway & Disease-focused RT2 Profiler PCR Arrays including VTN: 
              Extracellular Matrix & Adhesion Molecules in human mouse rat
              Wound Healing in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for VTN
    OriGene qSTAR qPCR primer pairs in human, mouse for VTN
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat VTN
    QuantiTect SYBR Green Assays in human, mouse, rat VTN
    QuantiFast Probe-based Assays in human, mouse, rat VTN
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VTN

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for VTN gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Vtn1 , 5 vitronectin1, 5 79.38(n)1
    75.64(a)1
      11 (46.74 cM)5
    223701  NM_011707.21  NP_035837.11 
     784990915 
    chicken
    (Gallus gallus)
    Aves VTN1 vitronectin 64.95(n)
    61.74(a)
      395935  NM_205061.1  NP_990392.1 
    lizard
    (Anolis carolinensis)
    Reptilia VTN6
    vitronectin
    51(a)
    1 ↔ 1
    GL343470.1(569004-573873)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.98442 Xenopus laevis transcribed sequence with weak similarity more 75.03(n)    CF547304.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.134662 Danio rerio cDNA clone IMAGE5409846, partial cds 71.23(n)    BC055570.1 


    ENSEMBL Gene Tree for VTN (if available)
    TreeFam Gene Tree for VTN (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for VTN gene
    PRG42  ENSG000002731712  
    3 SIMAP similar genes for VTN using alignment to 4 protein entries:     VTNC_HUMAN (see all proteins):
    SEBOX    DUX2    PRG4

    VTN for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for VTN (see all 134)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs22277291,2
    C,F,A,H--26694296(-) TAAAAT/CTATTG 1 -- ds500121Minor allele frequency- C:0.16NS EA NA CSA WA 3014
    rs776792591,2
    C--26694329(+) ATTGGG/ACTGGG 1 -- ut313Minor allele frequency- A:0.01CSA NS WA 655
    rs1502413351,2
    F--26694432(+) TGAGCG/AATGGA 2 /I syn11Minor allele frequency- A:0.00NA 4540
    rs1413686341,2
    C--26694460(+) CCACAA/GTGTCC 2 T I mis10--------
    rs22277281,2
    C,F,O,A,H--26694483(-) GTCAAT/CCTTCG 2 /N syn128Minor allele frequency- C:0.12NS NA EA CSA WA EU 9008
    rs1437890071,2
    C--26694484(+) GAAGAC/TTGACT 2 N S mis10--------
    rs22277271,2
    C,F--26694528(-) CTCACG/ACATCC 1 -- int15Minor allele frequency- A:0.02NS WA 750
    rs1512866721,2
    C--26694529(+) GATGCA/GTGAGG 1 -- int10--------
    rs1404743031,2
    --26694575(+) TCTAGA/GGTCTC 1 -- int10--------
    rs22277261,2
    C,F,A,H--26694661(-) CTGAAC/TGCAGC 1 -- int17Minor allele frequency- T:0.17NS NA CSA WA EA 459

    HapMap Linkage Disequilibrium report for VTN (26691290 - 26700110 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for VTN:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv519388CNV Loss19592680

    Human Gene Mutation Database (HGMD): VTN
    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing VTN
    DNA2.0 Custom Variant and Variant Library Synthesis for VTN

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 193190    OMIM disorders: --

    Selected diseases for VTN (see all 99):    
    About MalaCards
    colonic disease    camptodactyly arthropathy coxa vara pericarditis syndrome    congenital nephrotic syndrome finnish type    thrombasthenia
    proliferative diabetic retinopathy    mastitis    glanzmann's thrombasthenia    dense deposit disease
    diabetic retinopathy    hemorrhagic fever with renal syndrome    pericarditis    proliferative vitreoretinopathy
    arthropathy    nephrotic syndrome    nephritis    pseudoxanthoma elasticum
    fibrosarcoma    disseminated intravascular coagulation    dermatomyositis    mouth disease


    VTN for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for VTN gene (see all 92)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glanzmann thrombasthenia 56.3 3 9361020 (1), 1726706 (1)
    drusen 55.6 28 10064614 (4), 10329419 (4), 11846519 (2), 10783137 (2) (see all 13)
    metastasis 48.4 17 12447999 (2), 7694604 (1), 11988838 (1), 15493875 (1) (see all 13)
    melanoma 47.2 40 9096674 (4), 7545129 (3), 10428859 (1), 8423675 (1) (see all 32)
    tumors 42.3 102 10389948 (4), 11433393 (4), 1721625 (3), 8751559 (3) (see all 54)
    neovascularization 35.9 3 15596522 (2), 12766088 (1)
    vitreoretinopathy proliferative 33.7 11 1694159 (2), 7514582 (2), 1708748 (1), 1698696 (1) (see all 6)
    glioma 32.3 38 10389948 (4), 7749720 (4), 17886558 (4), 7543163 (3) (see all 17)
    osteosarcoma 30.3 8 16569238 (2), 16897174 (1), 1712876 (1), 16012763 (1) (see all 6)
    fibrosarcoma 28.8 10 9164658 (3), 16052409 (2), 7521757 (1), 12447999 (1)

    Genetic Association Database (GAD): VTN
    Human Genome Epidemiology (HuGE) Navigator: VTN (8 documents)

    Export disorders for VTN gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for VTN gene, integrated from 10 sources (see all 1118):
    (articles sorted by number of sources associating them with VTN)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Nucleotide sequence and organization of the human S-protein gene: repeating peptide motifs in the 'pexin' family and a model for their evolution. (PubMed id 2447940)1, 2, 3 Jenne D.E. and Stanley K.K. (Biochemistry 1987)
    2. Phosphorylation of vitronectin by casein kinase II. Identification of the sites and their promotion of cell adhesion and spreading. (PubMed id 9733784)1, 2, 9 Seger D.... Shaltiel S. (J. Biol. Chem. 1998)
    3. Identification of a PAI-1 binding site in vitronectin. (PubMed id 7522053)1, 2, 9 Sigurdardottir O. and Wiman B. (Biochim. Biophys. Acta 1994)
    4. Evidence that type 1 plasminogen activator inhibitor binds to the somatomedin B domain of vitronectin. (PubMed id 1704366)1, 2, 9 Seiffert D. and Loskutoff D.J. (J. Biol. Chem. 1991)
    5. How vitronectin binds PAI-1 to modulate fibrinolysis and cell migration. (PubMed id 12808446)1, 2, 9 Zhou A.... Read R.J. (Nat. Struct. Biol. 2003)
    6. The phosphorylation of the two-chain form of vitronectin by protein kinase A is heparin dependent. (PubMed id 1696913)1, 2, 9 Chain D.... Shaltiel S. (FEBS Lett. 1990)
    7. The binding protein for globular heads of complement C1q, gC1qR. Functional expression and characterization as a novel vitronectin binding factor. (PubMed id 8900153)1, 2, 9 Lim B.L....Preissner K.T. (J. Biol. Chem. 1996)
    8. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    9. The variant rs1867277 in FOXE1 gene confers thyroid cancer susceptibility through the recruitment of USF1/USF2 transcription factors. (PubMed id 19730683)1, 4 Landa I....Robledo M. (PLoS Genet. 2009)
    10. Association between the SERPING1 gene and age-related macular degeneration: a two-stage case-control study. (PubMed id 18842294)1, 4 Ennis S....Lotery A. (Lancet 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7448 HGNC: 12724 AceView: VTN Ensembl:ENSG00000109072 euGenes: HUgn7448
    ECgene: VTN Kegg: 7448 H-InvDB: VTN

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for VTN Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for VTN Genetics and Cytogenetics in Oncology and Haematology
    SeattleSNPshttp://pga.gs.washington.edu/data/vtn/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for VTN gene:
    Search GeneIP for patents involving VTN

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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