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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

VTN Gene

protein-coding GIFtS: 65
GCID: GC17M026890

vitronectin

(Previous names: vitronectin (serum spreading factor, somatomedin B, complement...)

Explore 104 diseases affiliated with
VTN via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Vitronectin¹		Vitronectin (Serum Spreading Factor, Somatomedin B, Complement S-Protein)¹
VN¹ ² ³		Complement S-Protein²
Serum-Spreading Factor² ³		Epibolin¹
S-Protein¹		Serum Spreading Factor²
V75² ³		Somatomedin B²
VNT² ⁵

External Ids:	HGNC: 12724¹	Entrez Gene: 7448²	Ensembl: ENSG00000255604⁷	OMIM: 193190⁵	UniProtKB: P04004³

Export aliases for VTN gene to outside databases

Previous GC identifers: GC17M026549 GC17M028594 GC17M026839 GC17M023718 GC17M026692 GC17M026753

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for VTN:

The protein encoded by this gene is a member of the pexin family. It is found in serum and tissues and promotes cell

adhesion and spreading, inhibits the membrane-damaging effect of the terminal cytolytic complement pathway, and binds

to several serpin serine protease inhibitors. It is a secreted protein and exists in either a single chain form or a

clipped, two chain form held together by a disulfide bond. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: VTNC_HUMAN, P04004

Function: Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with

glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a

cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement

pathway

Function: Somatomedin-B is a growth hormone-dependent serum factor with protease-inhibiting activity

Gene Wiki entry for VTN (Vitronectin)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000017.10 NC_018928.1 NT_010799.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the VTN gene promoter:
HTF p300 NRSF form 1 NF-kappaB NRSF form 2 GATA-2 ARP-1 NF-kappaB1 LyF-1 ATF
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): VTN promoter sequence

Search SABiosciences Chromatin IP Primers for VTN

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat VTN

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q11 Ensembl cytogenetic band: 17q11.2 HGNC cytogenetic band: 17q11.2

VTN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
VTN gene location

GeneLoc information about chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17M026890: view genomic region (about GC identifiers)

Start:	26,694,297 bp from pter	End:	26,700,110 bp from pter
Size:	5,814 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: VTNC_HUMAN, P04004 (See protein sequence)

Recommended Name: Vitronectin precursor

Size: 478 amino acids; 54306 Da

Subunit: Exists in two forms: a single chain 75 kDa form (V75) and a clipped form composed of two chains (65 kDa and 10

kDa) (V65+V10) which are held together by a disulfide bond. Interacts with SERPINE1/PAI1, insulin and C1QBP

Subcellular location: Secreted, extracellular space

6 PDB 3D structures from and Proteopedia for VTN:

1OC0 (3D)

1S4G (3D)

1SSU (3D)

2JQ8 (3D)

3BT1 (3D)

3BT2 (3D)

Secondary accessions: B2R7G0 P01141 Q9BSH7

Explore the universe of human proteins at neXtProt for VTN: NX_P04004

Post-translational modifications:

Sulfated on 2 tyrosine residues¹

N- and O-glycosylated (By similarity)¹

Phosphorylation on Thr-69 and Thr-76 favors cell adhesion and spreading¹

It has been suggested that the active SMB domain may be permitted considerable disulfide bond heterogeneity or

variability, thus two alternate disulfide patterns based on 3D structures are described with 1 disulfide bond

conserved in both¹

Phosphorylation sites are present in the extracellular medium¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P04004

VTN Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_000629.3

ENSEMBL proteins:

ENSP00000226218 ENSP00000440439

Reactome Protein details: P04004
Human Recombinant Protein Products:

	EMD Millipore Purified and/or Recombinant VTN Protein
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	Novus Biologicals VTN Proteins Novus Biologicals VTN Lysates
	Sino Biological Recombinant Protein for VTN
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for VTN

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	--
GO:0005578	proteinaceous extracellular matrix	--	--
GO:0005615	extracellular space	IDA	1695900
GO:0031012	colocalizes with extracellular matrix	ISS	--
GO:0071062	alphav-beta3 integrin-vitronectin complex	TAS	19267251

VTN for ontologies About GeneDecksing

VTN Antibody Products:

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	Novus Biologicals VTN Antibodies
	Abcam antibodies for VTN
	Uscn Antibodies for VTN
	ThermoFisher Antibody for VTN

Assay Products for VTN:

	EMD Millipore Kits and Assays for the Analysis of VTN
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for VTN
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for VTN

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

VTN for domains About GeneDecksing

5 InterPro domains/families:

IPR000585 Hemopexin/matrixin

IPR018486 Hemopexin/matrixin_CS

IPR018487 Hemopexin/matrixin_repeat

IPR020436 Somatomedin_B_chordata

IPR001212 Somatomedin_B_dom

Graphical View of Domain Structure for InterPro Entry P04004

ProtoNet protein and cluster: P04004

1 Blocks protein family: IPB001212 Somatomedin B

UniProtKB/Swiss-Prot: VTNC_HUMAN, P04004

Domain: The SMB domain mediates interaction with SERPINE1/PAI1. The heparin-binding domain mediates interaction with

insulin

Similarity: Contains 4 hemopexin-like domains

Similarity: Contains 1 SMB (somatomedin-B) domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: VTNC_HUMAN, P04004

Function: Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with

glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a

cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement

pathway

Function: Somatomedin-B is a growth hormone-dependent serum factor with protease-inhibiting activity

Genatlas biochemistry entry for VTN:

vitronectin,complement S protein (75kDa),precursor of 65 and 10kDa chains

miRNA Products:		OriGene 3'-UTR Clone: VTN Browse MicroRNA Expression Plasmids
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for VTN
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VTN

Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005044	scavenger receptor activity	IEA	--
GO:0005178	integrin binding	IPI	8837777
GO:0005515	protein binding	IPI	8900153
GO:0008201	heparin binding	IEA	--
GO:0030247	polysaccharide binding	IEA	--

VTN for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-out Vtn^tm1Dgi for VTN
     3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Vtn):

hematopoietic system

homeostasis/metabolism

normal

VTN for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/17 super-pathways (see all 17) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Cell adhesion_Integrin-mediated cell adhesion and migration

	Cytoskeleton remodeling_Integrin outside-in signaling	0.37			Cell adhesion_Endothelial cell contacts by non-junctional mechanisms	0.21
	Cytoskeleton remodeling Integrin outside-in signaling	0.37			Cell adhesion Endothelial cell contacts by non-junctional mechanisms	0.21

Elastic fibre formation

Elastic fibre formation

1.00

Molecules associated with elastic fibres

0.84

ECM-receptor interaction

ECM-receptor interaction

1.00

Integrin cell surface interactions

0.32

Focal Adhesion

Focal Adhesion

1.00

Focal adhesion

0.66

Cell adhesion_ECM remodeling

Cell adhesion_ECM remodeling

1.00

Cell adhesion ECM remodeling

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

5 EMD Millipore Pathways for VTN

	Cytoskeleton remodeling Integrin outside-in signaling
	Development VEGF-family signaling
	Cell adhesion PLAU signaling
	Cell adhesion ECM remodeling
	Cell adhesion Endothelial cell contacts by non-junctional mechanisms

3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for VTN

	Glioma Invasiveness
	UPA-UPAR Pathway
	Phagocytosis of Microbes

5 GeneGo (Thomson Reuters) Pathways for VTN

	Development VEGF-family signaling
	Cell adhesion Endothelial cell contacts by non-junctional mechanisms
	Cytoskeleton remodeling Integrin outside-in signaling
	Cell adhesion PLAU signaling
	Cell adhesion ECM remodeling

5/6 BioSystems Pathways for VTN (see all 6)

	Focal Adhesion
	Senescence and Autophagy
	FOXA1 transcription factor network
	amb2 Integrin signaling
	Integrins in angiogenesis

5 Reactome Pathways for VTN

	Molecules associated with elastic fibres
	Extracellular matrix organization
	Integrin cell surface interactions
	Elastic fibre formation
	Signal Transduction

2 Kegg Pathways (Kegg details for VTN):

	Focal adhesion
	ECM-receptor interaction

VTN for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for VTN

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/77 Interacting proteins for VTN (P04004^{1, 2, 3} ENSP00000226218⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 77)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SERPINE1	P05121²^,³, ENSP00000223095⁴	MINT-24884 I2D: score=4 STRING: ENSP00000223095
PASK	Q96RG2²^,³, ENSP00000234040⁴	MINT-8148755 I2D: score=1 STRING: ENSP00000234040
COPS5	Q92905³, ENSP00000350512⁴	I2D: score=2 STRING: ENSP00000350512
GEM	P55040³, ENSP00000297596⁴	I2D: score=2 STRING: ENSP00000297596
IGFBP5	P24593³, ENSP00000233813⁴	I2D: score=2 STRING: ENSP00000233813

About this table

Gene Ontology (GO): 5/15 biological process terms (GO ID links to tree view) (see all 15): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006955	immune response	IEA	--
GO:0007155	cell adhesion	TAS	2418831
GO:0007160	cell-matrix adhesion	IDA	10022831
GO:0010811	positive regulation of cell-substrate adhesion	--	--
GO:0010951	negative regulation of endopeptidase activity	IDA	1695900

VTN for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

VTN for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for VTN

1 DrugBank Compound for VTN About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Abciximab	7E3 antibody (see all 4)	143653-53-6	target	--	12749745 17160551

10/106 Novoseek chemical compound relationships for VTN gene (see all 106) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
lm 609	85.3	11	18331351 (2), 1703545 (1), 1383272 (1), 11249574 (1) (see all 8)
grgds	83.2	14	7689480 (2), 7542937 (1), 8972713 (1), 1281631 (1) (see all 13)
echistatin	80.6	21	8635506 (3), 9353406 (2), 7615123 (2), 7687129 (2) (see all 12)
fibrinogen	80.2	333	1708387 (7), 1717474 (5), 7545129 (5), 1707057 (5) (see all 99)
grgdsp	77.8	9	8486712 (1), 10563507 (1), 8761939 (1), 1382615 (1) (see all 8)
grgdspk	69.8	2	9120775 (1), 9426454 (1)
heparin	66	268	10037735 (8), 1708387 (7), 11437360 (7), 10545182 (6) (see all 97)
barbourin	63.7	1	8635506 (1)
matrigel	62	23	9177878 (2), 8634137 (2), 18599809 (2), 11369141 (1) (see all 20)
eristostatin	61.2	2	8706902 (1), 8635506 (1)

Search CenterWatch for drugs/clinical trials and news about VTN / VTNC

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for VTN gene:

NM_000638.3

Unigene Cluster for VTN:

Vitronectin

Hs.2257 [show with all ESTs]

Unigene Representative Sequence: AK298441

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000226218(uc002hbc.3) ENST00000539746 ENST00000542029

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat VTN

Additional cDNA sequence:

AK298441.1 AK312968.1 BC005046.1 X03168.1

15 DOTS entries:

DT.454116 DT.100885455 DT.100885459 DT.91753762 DT.100885454 DT.100885466 DT.319122 DT.100885475

DT.40240655 DT.91753757 DT.86854853 DT.95326649 DT.100885458 DT.91753753 DT.91753755

24/411 AceView cDNA sequences (see all 411):

CR615837 T28597 CB114897 CR615135 CB148811 BX405667 BX448138 BM927779

CB146958 CR617303 BU944551 CR605180 CR593593 BX346210 CR616555 CB130122

AI701395 CR608327 AL531136 BC005046 BX956150 BU541932 BX405601 H73713

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

VTN expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCCGGGCCCT

About this image

VTN expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

10/18 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 18)

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Epicardium

Endochondral Osteocytes

Bone

Caudal Endochondral Bones

Endochondral Osteoblasts

Bone

Caudal Endochondral Bones

Endochondral Osteocytes

Bone

Endochondral Facial Bones

Endochondral Osteoblasts

Bone

Endochondral Facial Bones

Endochondral Osteocytes

Bone

Rostral Endochondral Facial Bones

Endochondral Osteoblasts

Bone

Rostral Endochondral Facial Bones

Endochondral Osteocytes

Bone

Stylopod Periosteum

Endochondral Osteocytes

Bone

Zeugopod Periosteum

Endochondral Osteocytes

Bone

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 3 LifeMap Cells

Name

Category

Endoderm progenitor-like cells (Generation and expan...)

Pancreatic endoderm/endocrine precursor-like cells (A scalable, suspensi...)

Podocalyxin+, CD24+, GCTM2- (Derivation and sorti...)

See VTN Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for VTN

SOURCE GeneReport for Unigene cluster: Hs.2257

UniProtKB/Swiss-Prot: VTNC_HUMAN, P04004

Tissue specificity: Plasma

SABiosciences Expression via Pathway-Focused PCR Arrays including VTN:

Extracellular Matrix & Adhesion Molecules in human mouse rat

Wound Healing in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VTN

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for VTN gene from 4/14 species (see all 14) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	VTN¹	vitronectin	64.64(n) 61.35(a)		395935 NM_205061.1 NP_990392.1
lizard (Anolis carolinensis)	Reptilia	VTN⁶	--	52(a)	1 ↔ 1	GL343470.1(569004-573873)
African clawed frog (Xenopus laevis)	Amphibia	Xl.9844²	Xenopus laevis transcribed sequence with weak similarity more	75.03(n)		CF547304.1
zebrafish (Danio rerio)	Actinopterygii	Dr.13466²	Danio rerio cDNA clone IMAGE5409846, partial cds	71.23(n)		BC055570.1

ENSEMBL Gene Tree for VTN (if available)
TreeFam Gene Tree for VTN (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for VTN gene

ENSG00000258852² PRG4²

1 SIMAP similar gene for VTN using alignment to 3 protein entries: VTNC_HUMAN (see all proteins):

PRG4

VTN for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 17 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs2227719^1,2	C,F,	--	22905972(-)	`AGAGAG/CATAAA`	1	--	us2k¹		10		NS WA	1436
rs16964236^1,2	C,H	--	22906142(-)	`CCAGGG/AATGTG`	1	--	us2k¹		5		MN EA NS NA	532
rs2227717^1,2	C	--	22906780(-)	`ACGTGG/AGAGCA`	1	--	us2k¹		3		NS	640
rs71372373^1,2	C,F	--	22906995(+)	`GAGGCG/TGGGCG`	1	--	us2k¹		2		NA	4
rs11407609^1,2	C,	--	22907083(+)	`GTCGG-/CCCGGG`	1	--	us2k¹		0	--	--	--	--
rs113251283^1,2	C,F,	--	22907383(-)	`GGACCC/TGAGAG`	1	--	us2k¹		2		NS WA	672
rs113936866^1,2	C,F,	--	22907399(-)	`GGTTTT/CGGGAA`	1	--	ut5¹		2		NS WA	674
rs75957834^1,2	C,F,	--	26693846(+)	`GCACAG/ATGACT`	2	--	us2k¹ ds500¹		2		NS NA	654
rs183296109^1,2		--	26693924(+)	`CAGAAC/TCCCAC`	2	--	ds500¹ us2k¹		0	--	--	--	--
rs2227731^1,2	C,F,	--	26693956(-)	`GGTCTT/CGGAGG`	2	--	us2k¹ ds500¹		4		NS WA	738

HapMap Linkage Disequilibrium report for VTN (26694297 - 26700110 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for VTN: --
Human Gene Mutation Database (HGMD): VTN

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

VTN for disorders           About GeneDecksing

OMIM gene information: 193190    OMIM disorders: --

20/104 diseases for VTN (see all 104):    About MalaCards

camptodactyly-arthropathy-coxa vara-pericarditis syndrome disseminated intravascular coagulation glanzmann's thrombasthenia congenital nephrotic syndrome finnish type

proliferative diabetic retinopathy age related macular degeneration diabetic retinopathy thrombasthenia

hemorrhagic fever proliferative vitreoretinopathy macular degeneration squamous cell carcinoma

pericarditis nephrotic syndrome hemorrhagic fever with renal syndrome lupus erythematosus

vitreoretinopathy mouth disease haemophilus influenzae myocardial infarction

10/92 Novoseek disease relationships for VTN gene (see all 92) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
glanzmann thrombasthenia	56.3	3	9361020 (1), 1726706 (1)
drusen	55.6	28	10064614 (4), 10329419 (4), 11846519 (2), 10783137 (2) (see all 13)
metastasis	48.4	17	12447999 (2), 7694604 (1), 11988838 (1), 15493875 (1) (see all 13)
melanoma	47.2	40	9096674 (4), 7545129 (3), 10428859 (1), 8423675 (1) (see all 32)
tumors	42.3	102	10389948 (4), 11433393 (4), 1721625 (3), 8751559 (3) (see all 54)
neovascularization	35.9	3	15596522 (2), 12766088 (1)
vitreoretinopathy proliferative	33.7	11	1694159 (2), 7514582 (2), 1708748 (1), 1698696 (1) (see all 6)
glioma	32.3	38	10389948 (4), 7749720 (4), 17886558 (4), 7543163 (3) (see all 17)
osteosarcoma	30.3	8	16569238 (2), 16897174 (1), 1712876 (1), 16012763 (1) (see all 6)
fibrosarcoma	28.8	10	9164658 (3), 16052409 (2), 7521757 (1), 12447999 (1)

Human Genome Epidemiology (HuGE) Navigator: VTN (8 documents)

Export disorders for VTN gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for VTN gene, integrated from 9 sources (see all 1108):
(articles sorted by number of sources associating them with VTN)

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world of online information

Nucleotide sequence and organization of the human S-protein gene: repeating peptide motifs in the 'pexin' family and a model for their evolution. (PubMed id 2447940)^{1, 2, 3} Jenne D.E. and Stanley K.K. (1987)
Phosphorylation of vitronectin by casein kinase II. Identification of the sites and their promotion of cell adhesion and spreading. (PubMed id 9733784)^{1, 2, 9} Seger D.... Shaltiel S. (1998)
Identification of a PAI-1 binding site in vitronectin. (PubMed id 7522053)^{1, 2, 9} Sigurdardottir O. and Wiman B. (1994)
Evidence that type 1 plasminogen activator inhibitor binds to the somatomedin B domain of vitronectin. (PubMed id 1704366)^{1, 2, 9} Seiffert D. and Loskutoff D.J. (1991)
How vitronectin binds PAI-1 to modulate fibrinolysis and cell migration. (PubMed id 12808446)^{1, 2, 9} Zhou A.... Read R.J. (2003)
The phosphorylation of the two-chain form of vitronectin by protein kinase A is heparin dependent. (PubMed id 1696913)^{1, 2, 9} Chain D.... Shaltiel S. (1990)
The binding protein for globular heads of complement C1q, gC1qR. Functional expression and characterization as a novel vitronectin binding factor. (PubMed id 8900153)^{1, 2, 9} Lim B.L....Preissner K.T. (1996)
Phosphoproteomic analysis of the human pituitary. (PubMed id 16807684)^{1, 2} Beranova-Giorgianni S.... Giorgianni F. (2006)
Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)^{1, 2} Liu T.... Smith R.D. (2005)
Screening for N-glycosylated proteins by liquid chromatography mass spectrometry. (PubMed id 14760718)^{1, 2} Bunkenborg J.... Wisniewski J.R. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 7448	HGNC: 12724	AceView: VTN	Ensembl:ENSG00000255604	euGenes: HUgn7448
ECgene: VTN	Kegg: 7448	H-InvDB: VTN

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for VTN	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for VTN	Genetics and Cytogenetics in Oncology and Haematology
SeattleSNPs	http://pga.gs.washington.edu/data/vtn/

Intellectual Property for VTN gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for VTN gene:
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GeneCards and IP:
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