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Aliases for VTI1B Gene

Aliases for VTI1B Gene

  • Vesicle Transport Through Interaction With T-SNAREs 1B 2 3
  • VTI1L 3 4 6
  • VTI1 3 4 6
  • Vesicle Transport V-SNARE Protein Vti1-Like 1 3 4
  • Vti1-Rp1 3 4
  • VTI2 3 4
  • Vesicle Transport Through Interaction With T-SNAREs Homolog 1B (Yeast) 2
  • Vesicle Transport Through Interaction With T-SNAREs Homolog 1B 3
  • Vesicle-Associated Soluble NSF Attachment Protein Receptor 3
  • VTI1-LIKE 3
  • V-SNARE 3
  • VTI1L1 4

External Ids for VTI1B Gene

Previous GeneCards Identifiers for VTI1B Gene

  • GC14M061911
  • GC14M066103
  • GC14M066107
  • GC14M067187
  • GC14M068117
  • GC14M048287

Summaries for VTI1B Gene

GeneCards Summary for VTI1B Gene

VTI1B (Vesicle Transport Through Interaction With T-SNAREs 1B) is a Protein Coding gene. Among its related pathways are Delta508-CFTR traffic / ER-to-Golgi in CF and Delta508-CFTR traffic / ER-to-Golgi in CF. An important paralog of this gene is VTI1A.

UniProtKB/Swiss-Prot for VTI1B Gene

  • V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. May be concerned with increased secretion of cytokines associated with cellular senescence

Gene Wiki entry for VTI1B Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VTI1B Gene

Genomics for VTI1B Gene

Regulatory Elements for VTI1B Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for VTI1B Gene

Start:
67,647,075 bp from pter
End:
67,674,885 bp from pter
Size:
27,811 bases
Orientation:
Minus strand

Genomic View for VTI1B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for VTI1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VTI1B Gene

Proteins for VTI1B Gene

  • Protein details for VTI1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UEU0-VTI1B_HUMAN
    Recommended name:
    Vesicle transport through interaction with t-SNAREs homolog 1B
    Protein Accession:
    Q9UEU0
    Secondary Accessions:
    • O43547
    • Q96J28

    Protein attributes for VTI1B Gene

    Size:
    232 amino acids
    Molecular mass:
    26688 Da
    Quaternary structure:
    • Forms a SNARE complex with STX7, STX8 and VAMP8 which functions in the homotypic fusion of late endosomes. Component of the SNARE complex composed of STX7, STX8, VAMP7 and VIT1B that is required for heterotypic fusion of late endosomes with lysosomes (By similarity). May interact with STX17.

    Three dimensional structures from OCA and Proteopedia for VTI1B Gene

    Alternative splice isoforms for VTI1B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for VTI1B Gene

Proteomics data for VTI1B Gene at MOPED

Post-translational modifications for VTI1B Gene

  • Ubiquitination at Lys13
  • Modification sites at PhosphoSitePlus

Other Protein References for VTI1B Gene

No data available for DME Specific Peptides for VTI1B Gene

Domains for VTI1B Gene

Protein Domains for VTI1B Gene

Suggested Antigen Peptide Sequences for VTI1B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UEU0

UniProtKB/Swiss-Prot:

VTI1B_HUMAN :
  • Q9UEU0
Family:
  • Belongs to the VTI1 family.
genes like me logo Genes that share domains with VTI1B: view

No data available for Gene Families for VTI1B Gene

Function for VTI1B Gene

Molecular function for VTI1B Gene

UniProtKB/Swiss-Prot Function: V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. May be concerned with increased secretion of cytokines associated with cellular senescence

Gene Ontology (GO) - Molecular Function for VTI1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000149 SNARE binding IDA 24550300
GO:0005484 SNAP receptor activity IBA --
GO:0005515 protein binding IPI 25416956
GO:0019869 chloride channel inhibitor activity IDA 18570918
genes like me logo Genes that share ontologies with VTI1B: view
genes like me logo Genes that share phenotypes with VTI1B: view

Animal Models for VTI1B Gene

MGI Knock Outs for VTI1B:

Animal Model Products

miRNA for VTI1B Gene

miRTarBase miRNAs that target VTI1B

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for VTI1B

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for VTI1B Gene

Localization for VTI1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for VTI1B Gene

Late endosome membrane; Single-pass type IV membrane protein. Lysosome membrane. Cytoplasmic granule.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for VTI1B Gene COMPARTMENTS Subcellular localization image for VTI1B gene
Compartment Confidence
endosome 5
golgi apparatus 5
lysosome 5
vacuole 5
nucleus 2
cytosol 1
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for VTI1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005765 lysosomal membrane IDA 23217709
GO:0005789 endoplasmic reticulum membrane IBA --
GO:0005794 Golgi apparatus IDA --
GO:0008021 synaptic vesicle ISS --
genes like me logo Genes that share ontologies with VTI1B: view

Pathways for VTI1B Gene

genes like me logo Genes that share pathways with VTI1B: view

Gene Ontology (GO) - Biological Process for VTI1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000046 NOT autophagic vacuole fusion IMP 23217709
GO:0006623 protein targeting to vacuole IBA --
GO:0006886 intracellular protein transport --
GO:0006888 ER to Golgi vesicle-mediated transport IBA --
GO:0006891 intra-Golgi vesicle-mediated transport IBA --
genes like me logo Genes that share ontologies with VTI1B: view

Compounds for VTI1B Gene

(10) Novoseek inferred chemical compound relationships for VTI1B Gene

Compound -log(P) Hits PubMed IDs
lm-a1 87.5 1
vti 1 84.5 1
n-ethylmaleimide 61.6 4
calcium 33.3 6
atp 28.4 2
genes like me logo Genes that share compounds with VTI1B: view

Transcripts for VTI1B Gene

Unigene Clusters for VTI1B Gene

Vesicle transport through interaction with t-SNAREs 1B:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for VTI1B

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for VTI1B Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6
SP1: -
SP2: - -
SP3:

Relevant External Links for VTI1B Gene

GeneLoc Exon Structure for
VTI1B
ECgene alternative splicing isoforms for
VTI1B

Expression for VTI1B Gene

mRNA expression in normal human tissues for VTI1B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for VTI1B Gene

SOURCE GeneReport for Unigene cluster for VTI1B Gene Hs.741177

mRNA Expression by UniProt/SwissProt for VTI1B Gene

Q9UEU0-VTI1B_HUMAN
Tissue specificity: Expressed in all tissues examined
genes like me logo Genes that share expressions with VTI1B: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for VTI1B Gene

Orthologs for VTI1B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for VTI1B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia VTI1B 35
  • 100 (n)
  • 100 (a)
VTI1B 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia VTI1B 35
  • 92.1 (n)
  • 94.83 (a)
VTI1B 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia VTI1B 35
  • 91.67 (n)
  • 95.69 (a)
VTI1B 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Vti1b 35
  • 88.94 (n)
  • 92.67 (a)
Vti1b 16
Vti1b 36
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia VTI1B 36
  • 87 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Vti1b 35
  • 90.38 (n)
  • 93.03 (a)
chicken
(Gallus gallus)
Aves VTI1B 35
  • 72.59 (n)
  • 78.22 (a)
VTI1B 36
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 71 (a)
OneToMany
-- 36
  • 69 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.12013 35
vti1b 35
  • 63.44 (n)
  • 67.28 (a)
zebrafish
(Danio rerio)
Actinopterygii vti1b 35
  • 65.3 (n)
  • 64.55 (a)
vti1b 36
  • 61 (a)
OneToOne
zgc63525 35
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes VTI1 36
  • 22 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10438 36
  • 32 (a)
OneToOne
Species with no ortholog for VTI1B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for VTI1B Gene

ENSEMBL:
Gene Tree for VTI1B (if available)
TreeFam:
Gene Tree for VTI1B (if available)

Paralogs for VTI1B Gene

Paralogs for VTI1B Gene

Selected SIMAP similar genes for VTI1B Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for VTI1B Gene

genes like me logo Genes that share paralogs with VTI1B: view

Variants for VTI1B Gene

Sequence variations from dbSNP and Humsavar for VTI1B Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs761513 -- 67,668,272(+) GGTAA(C/T)TGGAG intron-variant
rs761514 -- 67,668,458(+) TACTT(C/T)GGAGA intron-variant
rs1535088 -- 67,655,417(+) GACAG(C/T)AGACT intron-variant
rs2092691 -- 67,669,570(+) CCCCC(A/G)TATGT intron-variant
rs2234502 -- 67,675,401(-) cagcc(G/T)ccggg upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for VTI1B Gene

Variant ID Type Subtype PubMed ID
nsv902068 CNV Gain 21882294
esv2678403 CNV Deletion 23128226
nsv521832 CNV Loss 19592680

Relevant External Links for VTI1B Gene

HapMap Linkage Disequilibrium report
VTI1B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VTI1B Gene

Disorders for VTI1B Gene

(2) Novoseek inferred disease relationships for VTI1B Gene

Disease -log(P) Hits PubMed IDs
tetanus 35.8 2
insulin resistance 4.9 1

Relevant External Links for VTI1B

Genetic Association Database (GAD)
VTI1B
Human Genome Epidemiology (HuGE) Navigator
VTI1B
genes like me logo Genes that share disorders with VTI1B: view

No data available for UniProtKB/Swiss-Prot for VTI1B Gene

Publications for VTI1B Gene

  1. A human homolog can functionally replace the yeast vesicle-associated SNARE Vti1p in two vesicle transport pathways. (PMID: 9446565) Fischer von Mollard G. … Stevens T.H. (J. Biol. Chem. 1998) 2 3 4 23
  2. A hVti1 homologue: its expression depends on population doubling levels in both normal and SV40-transformed human fibroblasts. (PMID: 9636656) Li H.-C. … Ide T. (Biochem. Biophys. Res. Commun. 1998) 2 3 4
  3. Endosomal SNARE proteins regulate CFTR activity and trafficking in epithelial cells. (PMID: 18570918) Bilan F. … Thoreau V. (Exp. Cell Res. 2008) 3 23
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. The hairpin-type tail-anchored SNARE syntaxin 17 targets to autophagosomes for fusion with endosomes/lysosomes. (PMID: 23217709) Itakura E. … Mizushima N. (Cell 2012) 3 4

Products for VTI1B Gene

  • Addgene plasmids for VTI1B

Sources for VTI1B Gene

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