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Aliases for VTI1B Gene

Aliases for VTI1B Gene

  • Vesicle Transport Through Interaction With T-SNAREs 1B 2 3 5
  • Vesicle Transport V-SNARE Protein Vti1-Like 1 3 4
  • Vti1-Rp1 3 4
  • VTI1L 3 4
  • VTI1 3 4
  • VTI2 3 4
  • Vesicle Transport Through Interaction With T-SNAREs Homolog 1B (Yeast) 2
  • Vesicle Transport Through Interaction With T-SNAREs Homolog 1B 3
  • Vesicle-Associated Soluble NSF Attachment Protein Receptor 3
  • VTI1-LIKE 3
  • V-SNARE 3
  • VTI1L1 4

External Ids for VTI1B Gene

Previous GeneCards Identifiers for VTI1B Gene

  • GC14M061911
  • GC14M066103
  • GC14M066107
  • GC14M067187
  • GC14M068117
  • GC14M048287

Summaries for VTI1B Gene

GeneCards Summary for VTI1B Gene

VTI1B (Vesicle Transport Through Interaction With T-SNAREs 1B) is a Protein Coding gene. Among its related pathways are Delta508-CFTR traffic / ER-to-Golgi in CF and Response to elevated platelet cytosolic Ca2+. GO annotations related to this gene include SNARE binding and chloride channel inhibitor activity. An important paralog of this gene is VTI1A.

UniProtKB/Swiss-Prot for VTI1B Gene

  • V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. May be concerned with increased secretion of cytokines associated with cellular senescence.

Gene Wiki entry for VTI1B Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VTI1B Gene

Genomics for VTI1B Gene

Regulatory Elements for VTI1B Gene

Enhancers for VTI1B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14F067650 0.2 ENCODE 17.5 +23.9 23859 1.1 BHLHE40 CEBPB VTI1B ENSG00000201529 ARG2 GC14M067653
GH14F067709 0.5 ENCODE 6.1 -35.1 -35087 1.1 CBX3 ZNF280D CEBPG ZNF518A HNF1A ATF3 CEBPA ZNF26 ZSCAN29 ZBTB33 RDH11 PIGH ARG2 ENSG00000201529 VTI1B RN7SL369P RPL21P9
GH14F067721 1.1 Ensembl ENCODE 6.1 -47.6 -47568 1.1 ZNF263 RFX1 SUZ12 SAP130 HCFC1 MAFG SIX5 RAD21 ETS1 ZNF316 ARG2 ENSG00000201529 PIGH VTI1B RPL21P9 ENSG00000271697
GH14F067665 0.8 Ensembl ENCODE 5.8 +8.0 8028 2.1 CTCF TFAP4 ZNF654 ARID4B TRIM22 REST RAD21 YY1 ZNF316 IKZF1 ARG2 PIGH ENSG00000201529 RDH11 RDH12 RN7SL369P VTI1B GC14M067658
GH14F067733 0.4 ENCODE 5 -59.7 -59737 2.7 CTCF MTA2 WT1 RDH11 VTI1B ENSG00000271697 RPL21P9
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around VTI1B on UCSC Golden Path with GeneCards custom track

Promoters for VTI1B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000098368 485 2401 PKNOX1 CREB3L1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 SLC30A9 ZNF207

Genomic Location for VTI1B Gene

Chromosome:
14
Start:
67,647,075 bp from pter
End:
67,674,885 bp from pter
Size:
27,811 bases
Orientation:
Minus strand

Genomic View for VTI1B Gene

Genes around VTI1B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
VTI1B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for VTI1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VTI1B Gene

Proteins for VTI1B Gene

  • Protein details for VTI1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UEU0-VTI1B_HUMAN
    Recommended name:
    Vesicle transport through interaction with t-SNAREs homolog 1B
    Protein Accession:
    Q9UEU0
    Secondary Accessions:
    • O43547
    • Q96J28

    Protein attributes for VTI1B Gene

    Size:
    232 amino acids
    Molecular mass:
    26688 Da
    Quaternary structure:
    • Forms a SNARE complex with STX7, STX8 and VAMP8 which functions in the homotypic fusion of late endosomes. Component of the SNARE complex composed of STX7, STX8, VAMP7 and VIT1B that is required for heterotypic fusion of late endosomes with lysosomes (By similarity). May interact with STX17.

    Three dimensional structures from OCA and Proteopedia for VTI1B Gene

    Alternative splice isoforms for VTI1B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for VTI1B Gene

Post-translational modifications for VTI1B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for VTI1B Gene

No data available for DME Specific Peptides for VTI1B Gene

Domains & Families for VTI1B Gene

Gene Families for VTI1B Gene

Protein Domains for VTI1B Gene

Suggested Antigen Peptide Sequences for VTI1B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UEU0

UniProtKB/Swiss-Prot:

VTI1B_HUMAN :
  • Belongs to the VTI1 family.
Family:
  • Belongs to the VTI1 family.
genes like me logo Genes that share domains with VTI1B: view

Function for VTI1B Gene

Molecular function for VTI1B Gene

UniProtKB/Swiss-Prot Function:
V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. May be concerned with increased secretion of cytokines associated with cellular senescence.

Gene Ontology (GO) - Molecular Function for VTI1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000149 SNARE binding IDA 24550300
GO:0005484 SNAP receptor activity IBA --
GO:0005515 protein binding IPI 16189514
GO:0019869 chloride channel inhibitor activity IDA 18570918
genes like me logo Genes that share ontologies with VTI1B: view
genes like me logo Genes that share phenotypes with VTI1B: view

Animal Models for VTI1B Gene

MGI Knock Outs for VTI1B:

Animal Model Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for VTI1B

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for VTI1B Gene

Localization for VTI1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for VTI1B Gene

Late endosome membrane; Single-pass type IV membrane protein. Lysosome membrane. Cytoplasmic granule.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for VTI1B Gene COMPARTMENTS Subcellular localization image for VTI1B gene
Compartment Confidence
endosome 5
golgi apparatus 5
lysosome 5
vacuole 5
cytosol 2
nucleus 2
plasma membrane 2
endoplasmic reticulum 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for VTI1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005764 lysosome IEA --
GO:0005765 lysosomal membrane IEA,IDA 23217709
GO:0005768 endosome IEA --
GO:0005789 endoplasmic reticulum membrane IBA --
genes like me logo Genes that share ontologies with VTI1B: view

Pathways & Interactions for VTI1B Gene

genes like me logo Genes that share pathways with VTI1B: view

Gene Ontology (GO) - Biological Process for VTI1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006623 protein targeting to vacuole IBA --
GO:0006810 transport IEA --
GO:0006886 intracellular protein transport IEA --
GO:0006888 ER to Golgi vesicle-mediated transport IBA --
GO:0006891 intra-Golgi vesicle-mediated transport IBA --
genes like me logo Genes that share ontologies with VTI1B: view

No data available for SIGNOR curated interactions for VTI1B Gene

Drugs & Compounds for VTI1B Gene

(5) Drugs for VTI1B Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(5) Additional Compounds for VTI1B Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with VTI1B: view

Transcripts for VTI1B Gene

Unigene Clusters for VTI1B Gene

Vesicle transport through interaction with t-SNAREs 1B:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for VTI1B

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for VTI1B Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6
SP1: -
SP2: - -
SP3:

Relevant External Links for VTI1B Gene

GeneLoc Exon Structure for
VTI1B
ECgene alternative splicing isoforms for
VTI1B

Expression for VTI1B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for VTI1B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for VTI1B Gene

This gene is overexpressed in Synovial fluid (20.1) and Peripheral blood mononuclear cells (16.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for VTI1B Gene



Protein tissue co-expression partners for VTI1B Gene

NURSA nuclear receptor signaling pathways regulating expression of VTI1B Gene:

VTI1B

SOURCE GeneReport for Unigene cluster for VTI1B Gene:

Hs.741177

mRNA Expression by UniProt/SwissProt for VTI1B Gene:

Q9UEU0-VTI1B_HUMAN
Tissue specificity: Expressed in all tissues examined.
genes like me logo Genes that share expression patterns with VTI1B: view

Primer Products

No data available for mRNA differential expression in normal tissues for VTI1B Gene

Orthologs for VTI1B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for VTI1B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia VTI1B 34 35
  • 100 (n)
cow
(Bos Taurus)
Mammalia VTI1B 34 35
  • 92.1 (n)
dog
(Canis familiaris)
Mammalia VTI1B 34 35
  • 91.67 (n)
rat
(Rattus norvegicus)
Mammalia Vti1b 34
  • 90.38 (n)
mouse
(Mus musculus)
Mammalia Vti1b 34 16 35
  • 88.94 (n)
oppossum
(Monodelphis domestica)
Mammalia VTI1B 35
  • 87 (a)
OneToOne
chicken
(Gallus gallus)
Aves VTI1B 34 35
  • 72.59 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 71 (a)
OneToMany
-- 35
  • 69 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia vti1b 34
  • 63.44 (n)
Str.12013 34
zebrafish
(Danio rerio)
Actinopterygii vti1b 34 35
  • 65.3 (n)
zgc63525 34
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes VTI1 35
  • 22 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10438 35
  • 32 (a)
OneToOne
Species where no ortholog for VTI1B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for VTI1B Gene

ENSEMBL:
Gene Tree for VTI1B (if available)
TreeFam:
Gene Tree for VTI1B (if available)

Paralogs for VTI1B Gene

Paralogs for VTI1B Gene

(1) SIMAP similar genes for VTI1B Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for VTI1B Gene

genes like me logo Genes that share paralogs with VTI1B: view

Variants for VTI1B Gene

Sequence variations from dbSNP and Humsavar for VTI1B Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs10136738 -- 67,658,591(+) gactc(C/T)gtctc intron-variant
rs10139064 -- 67,671,718(+) ctgga(A/G)gctgg intron-variant
rs10146242 -- 67,661,425(+) AGGTA(C/T)CAACT intron-variant
rs10148493 -- 67,667,287(+) GGAAA(C/T)AACTT intron-variant
rs10150344 -- 67,655,786(+) AAAGA(C/G)AGAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for VTI1B Gene

Variant ID Type Subtype PubMed ID
esv2678403 CNV deletion 23128226
esv3551696 CNV deletion 23714750
esv3634806 CNV loss 21293372
nsv521832 CNV loss 19592680

Variation tolerance for VTI1B Gene

Residual Variation Intolerance Score: 78.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.04; 21.27% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for VTI1B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
VTI1B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VTI1B Gene

Disorders for VTI1B Gene

Relevant External Links for VTI1B

Genetic Association Database (GAD)
VTI1B
Human Genome Epidemiology (HuGE) Navigator
VTI1B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
VTI1B

No disorders were found for VTI1B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for VTI1B Gene

Publications for VTI1B Gene

  1. A human homolog can functionally replace the yeast vesicle-associated SNARE Vti1p in two vesicle transport pathways. (PMID: 9446565) Fischer von Mollard G. … Stevens T.H. (J. Biol. Chem. 1998) 2 3 4 22 64
  2. A hVti1 homologue: its expression depends on population doubling levels in both normal and SV40-transformed human fibroblasts. (PMID: 9636656) Li H.-C. … Ide T. (Biochem. Biophys. Res. Commun. 1998) 2 3 4 64
  3. The hairpin-type tail-anchored SNARE syntaxin 17 targets to autophagosomes for fusion with endosomes/lysosomes. (PMID: 23217709) Itakura E. … Mizushima N. (Cell 2012) 3 4 64
  4. Combinational soluble N-ethylmaleimide-sensitive factor attachment protein receptor proteins VAMP8 and Vti1b mediate fusion of antimicrobial and canonical autophagosomes with lysosomes. (PMID: 20089838) Furuta N. … Amano A. (Mol. Biol. Cell 2010) 3 22 64
  5. Endosomal SNARE proteins regulate CFTR activity and trafficking in epithelial cells. (PMID: 18570918) Bilan F. … Thoreau V. (Exp. Cell Res. 2008) 3 22 64

Products for VTI1B Gene

Sources for VTI1B Gene

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