Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



VTI1B Gene

protein-coding   GIFtS: 59
GCID: GC14M068117

Vesicle Transport Through Interaction With T-SNAREs 1B

(Previous name: vesicle transport through interaction with t-SNAREs homolog...)
  Search for VTI1B
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Vesicle Transport Through Interaction With T-SNAREs 1B1 2     v-SNARE2
VTI12 3 5     Vesicle Transport Through Interaction With T-SNAREs Homolog 1B2
VTI1L2 3 5     Vesicle-Associated Soluble NSF Attachment Protein Receptor2
Vesicle Transport V-SNARE Protein Vti1-Like 12 3     vti1-rp12
VTI22 3     VTI1L13
Vesicle Transport Through Interaction With T-SNAREs Homolog 1B (Yeast)1     Vti1-rp13
VTI1-LIKE2     

External Ids:    HGNC: 177931   Entrez Gene: 104902   Ensembl: ENSG000001005687   OMIM: 6032075   UniProtKB: Q9UEU03   

Export aliases for VTI1B gene to outside databases

Previous GC identifers: GC14M061911 GC14M066103 GC14M066107 GC14M067187 GC14M048287


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for VTI1B Gene:
VTI1B (vesicle transport through interaction with t-SNAREs 1B) is a protein-coding gene. An important paralog of this gene is VTI1A.

UniProtKB/Swiss-Prot: VTI1B_HUMAN, Q9UEU0
Function: V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target
membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to
promote fusion of the lipid bilayers. May be concerned with increased secretion of cytokines associated with
cellular senescence

Gene Wiki entry for VTI1B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
Regulatory elements:
   Regulatory transcription factor binding sites in the VTI1B gene promoter:
         TBP   ER-alpha   p53   MEF-2   MyoD   Arnt   AREB6   MEF-2A   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidVTI1B promoter sequence
   Search Chromatin IP Primers for VTI1B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat VTI1B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q24.1   Ensembl cytogenetic band:  14q24.1   HGNC cytogenetic band: 14q23.3

VTI1B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
VTI1B gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M068117:  view genomic region     (about GC identifiers)

Start:
68,113,792 bp from pter      End:
68,141,602 bp from pter
Size:
27,811 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: VTI1B_HUMAN, Q9UEU0 (See protein sequence)
Recommended Name: Vesicle transport through interaction with t-SNAREs homolog 1B  
Size: 232 amino acids; 26688 Da
Subunit: Forms a SNARE complex with STX7, STX8 and VAMP8 which functions in the homotypic fusion of late
endosomes. Component of the SNARE complex composed of STX7, STX8, VAMP7 and VIT1B that is required for
heterotypic fusion of late endosomes with lysosomes (By similarity). May interact with STX17
1 PDB 3D structure from and Proteopedia for VTI1B:
2V8S (3D)    
Secondary accessions: O43547 Q96J28
Alternative splicing: 2 isoforms:  Q9UEU0-1   Q9UEU0-2   

Explore the universe of human proteins at neXtProt for VTI1B: NX_Q9UEU0

Explore proteomics data for VTI1B at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys13
  • Modification sites at PhosphoSitePlus

  • See VTI1B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006361.1  
    ENSEMBL proteins: 
     ENSP00000450731   ENSP00000451661   ENSP00000451759   ENSP00000216456   ENSP00000452366  

    VTI1B Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for VTI1B
    OriGene Protein Over-expression Lysate for VTI1B
    OriGene MassSpec for VTI1B
    OriGene Custom Protein Services for VTI1B
    GenScript Custom Purified and Recombinant Proteins Services for VTI1B
    Novus Biologicals VTI1B Protein
    Novus Biologicals VTI1B Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for VTI1B
    Cloud-Clone Corp. Proteins for VTI1B

     
    Search eBioscience for Proteins for VTI1B 

    VTI1B Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for VTI1B
    OriGene Custom Antibody Services for VTI1B
    Novus Biologicals VTI1B Antibodies
    Abcam antibodies for VTI1B
    Cloud-Clone Corp. Antibodies for VTI1B
    ThermoFisher Antibodies for VTI1B
    LSBio Antibodies in human, mouse, rat for VTI1B

    VTI1B Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for VTI1B
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for VTI1B
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for VTI1B
    Cloud-Clone Corp. CLIAs for VTI1B
    Search eBioscience for ELISAs for VTI1B 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    3 InterPro protein domains:
     IPR010989 t-SNARE
     IPR000727 T_SNARE_dom
     IPR007705 Vesicle_trsprt_v-SNARE_N

    Graphical View of Domain Structure for InterPro Entry Q9UEU0

    ProtoNet protein and cluster: Q9UEU0

    1 Blocks protein domain: IPB007705 Vesicle transport v-SNARE

    UniProtKB/Swiss-Prot: VTI1B_HUMAN, Q9UEU0
    Similarity: Belongs to the VTI1 family


    Find genes that share domains with VTI1B           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: VTI1B_HUMAN, Q9UEU0
    Function: V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target
    membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to
    promote fusion of the lipid bilayers. May be concerned with increased secretion of cytokines associated with
    cellular senescence

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    Find genes that share ontologies with VTI1B           About GenesLikeMe


    Phenotypes:
         7 MGI mutant phenotypes (inferred from 1 allele(MGI details for Vti1b):
     cellular  endocrine/exocrine gland  growth/size/body  liver/biliary system  mortality/aging 
     nervous system  vision/eye 

    Find genes that share phenotypes with VTI1B           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Vti1btm1Gfvm for VTI1B

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for VTI1B
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for VTI1B

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for VTI1B
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for VTI1B

    miRNA
    Products:
        
    miRTarBase miRNAs that target VTI1B:
    hsa-mir-16-5p (MIRT001397), hsa-mir-33a-5p (MIRT028226)

    Block miRNA regulation of human, mouse, rat VTI1B using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate VTI1B:
    hsa-miR-23b hsa-miR-130a* hsa-miR-23a hsa-miR-556-3p hsa-miR-23c
    SwitchGear 3'UTR luciferase reporter plasmidVTI1B 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for VTI1B
    Predesigned siRNA for gene silencing in human, mouse, rat VTI1B

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for VTI1B

    Clone
    Products:
         
    OriGene clones in human, mouse for VTI1B (see all 7)
    OriGene ORF clones in mouse, rat for VTI1B
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: VTI1B (NM_006370)
    Sino Biological Human cDNA Clone for VTI1B
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for VTI1B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VTI1B
    Addgene plasmids for VTI1B 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for VTI1B
    Browse ESI BIO Cell Lines and PureStem Progenitors for VTI1B 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VTI1B


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    VTI1B_HUMAN, Q9UEU0: Late endosome membrane; Single-pass type IV membrane protein. Lysosome membrane. Cytoplasmic
    granule
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endosome5
    golgi apparatus5
    lysosome5
    vacuole5
    nucleus2
    cytosol1
    mitochondrion1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005765lysosomal membrane IDA--
    GO:0005794Golgi apparatus IDA19224922
    GO:0016020membrane ----
    GO:0016021integral component of membrane IEA--
    GO:0031201SNARE complex IEA--

    Find genes that share ontologies with VTI1B           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for VTI1B About    
    See pathways by source

    SuperPathContained pathways About
    1Clathrin dependent protein traffic
    Transport Clathrin coated vesicle cycle0.66
    wtCFTR and delta508 CFTR traffic Generic schema norm and CF 0.37
    2Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics
    SNARE interactions in vesicular transport0.40
    3wtCFTR and deltaF508 traffic Late endosome and Lysosome norm and CF
    wtCFTR and deltaF508 traffic Late endosome and Lysosome norm and CF


    Find genes that share SuperPaths with VTI1B           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 GeneGo (Thomson Reuters) Pathways for VTI1B
        wtCFTR and delta508-CFTR traffic / Generic schema (norm and CF)
    Transport Clathrin-coated vesicle cycle
    wtCFTR and deltaF508 traffic / Late endosome and Lysosome (norm and CF)



    1 Kegg Pathway  (Kegg details for VTI1B):
        SNARE interactions in vesicular transport

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for VTI1B
    Interactions:

        GeneGlobe Interaction Network for VTI1B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for VTI1B (Q9UEU02, 3 ENSP000002164564) via UniProtKB, MINT, STRING, and/or I2D (see all 79)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    STX8Q9UNK02, 3, ENSP000003052554MINT-66165 I2D: score=7 STRING: ENSP00000305255
    GOLGB1Q147892, 3, ENSP000003418484MINT-64183 I2D: score=4 STRING: ENSP00000341848
    TNK2Q079122, 3MINT-64709 I2D: score=3 
    NSFP464593, ENSP000003812934I2D: score=3 STRING: ENSP00000381293
    STX7O154003, ENSP000003569184I2D: score=3 STRING: ENSP00000356918
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000046NOT autophagic vacuole fusion IMP--
    GO:0006886intracellular protein transport IEA--
    GO:0006904vesicle docking involved in exocytosis TAS9446565
    GO:0008283cell proliferation TAS9446565
    GO:0016192vesicle-mediated transport TAS9446565

    Find genes that share ontologies with VTI1B           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for VTI1B

    10 Novoseek inferred chemical compound relationships for VTI1B gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lm-a1 87.5 1 9657146 (1)
    vti 1 84.5 1 9446565 (1)
    n-ethylmaleimide 61.6 5 11066058 (1), 15037235 (1), 12244131 (1), 11781091 (1)
    calcium 33.3 11 19195551 (2), 17204559 (1), 16390104 (1), 19195550 (1) (see all 5)
    atp 28.4 2 11423412 (1), 15608145 (1)
    phospholipid 18.7 2 19195551 (1)
    lipid 13.9 7 11463334 (1), 19195551 (1), 16390104 (1), 19195550 (1)
    cysteine 12.7 2 17081110 (1), 14567912 (1)
    gtp 8.19 1 9657146 (1)
    glucose 2.91 1 10713150 (1)



    Find genes that share compounds with VTI1B           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for VTI1B gene: 
    NM_006370.2  

    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000554659(uc001xjt.3 uc010aqp.3 uc001xju.3) ENST00000554636
    ENST00000556461 ENST00000216456 ENST00000553619 ENST00000555543
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat VTI1B using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate VTI1B:
    hsa-miR-23b hsa-miR-130a* hsa-miR-23a hsa-miR-556-3p hsa-miR-23c
    SwitchGear 3'UTR luciferase reporter plasmidVTI1B 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for VTI1B
    Predesigned siRNA for gene silencing in human, mouse, rat VTI1B
    Clone
    Products:
         
    OriGene clones in human, mouse for VTI1B (see all 7)
    OriGene ORF clones in mouse, rat for VTI1B
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: VTI1B (NM_006370)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for VTI1B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VTI1B
    Addgene plasmids for VTI1B 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for VTI1B
    OriGene qSTAR qPCR primer pairs in human, mouse for VTI1B
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat VTI1B
      QuantiTect SYBR Green Assays in human, mouse, rat VTI1B
      QuantiFast Probe-based Assays in human, mouse, rat VTI1B

    Selected AceView cDNA sequences (see all 1100):

    AI963481 BM044225 BM721186 BE267556 AI056325 BQ947895 BQ890697 BE273727 
    BM661519 BE294361 BP360309 BU955833 BU541331 BE408821 CA419546 BE407156 
    BM128395 AW519091 BI114283 BM272282 BI825624 AA306983 BQ775842 BQ676126 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for VTI1B    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6
    SP1:                    -                                 
    SP2:              -     -                                 
    SP3:                                                      


    ECgene alternative splicing isoforms for VTI1B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    VTI1B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATGTTAGGGA
    VTI1B Expression
    About this image


    VTI1B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)
             Cerebral Cortex
     
     Thyroid (Endocrine System)
     
     Colon (Gastrointestinal Tract)
     
     Testis (Reproductive System)
     
     Adipose (Muscoskeletal System)
    VTI1B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    VTI1B Protein Expression

    UniProtKB/Swiss-Prot: VTI1B_HUMAN, Q9UEU0
    Tissue specificity: Expressed in all tissues examined

        Custom PCR Arrays for VTI1B
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for VTI1B
    OriGene qSTAR qPCR primer pairs in human, mouse for VTI1B
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat VTI1B
    QuantiTect SYBR Green Assays in human, mouse, rat VTI1B
    QuantiFast Probe-based Assays in human, mouse, rat VTI1B
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VTI1B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for VTI1B gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Vti1b1 , 5 vesicle transport through interaction with t-SNAREs more1, 5 88.94(n)1
    92.67(a)1
      12 (35.51 cM)5
    536121  NM_016800.31  NP_058080.21 
     791560175 
    chicken
    (Gallus gallus)
    Aves VTI1B1 vesicle transport through interaction with t-SNAREs more 72.59(n)
    78.22(a)
      423273  XM_421192.4  XP_421192.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    71(a)
    69(a)
    1 ↔ many
    1 ↔ many
    GL343272.1(1006371-1024225)
    GL343444.1(119277-121482)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.120132 Transcribed sequence with weak similarity to protein more 71.77(n)    BX732625.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc635252 similar to vesicle transport through interaction with more 73.28(n)   394011  BC055131.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes VTI16
    Protein involved in cis-Golgi membrane traffic; v-...
    22(a)
    1 → many
    XIII(658545-659198) YMR197C


    ENSEMBL Gene Tree for VTI1B (if available)
    TreeFam Gene Tree for VTI1B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for VTI1B gene
    VTI1A2  
    1 SIMAP similar gene for VTI1B using alignment to 5 protein entries:     VTI1B_HUMAN (see all proteins):
    VTI1A

    Find genes that share paralogs with VTI1B           About GenesLikeMe


    4 Pseudogenes.org Pseudogenes for VTI1B
    PGOHUM00000239791 PGOHUM00000238116 PGOHUM00000246153 PGOHUM00000236776


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for VTI1B (see all 561)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs350584301,2
    C--49109043(+) AAAAAA/-TTAAT 1 -- int11Minor allele frequency- -:0.00NA 2
    rs1910226151,2
    --68119085(+) TGAAGA/TCAATC 1 -- int10--------
    rs171045471,2
    C,F,H--68119093(+) ATCCCA/GTTTCT 1 -- int19Minor allele frequency- G:0.07NA NS EA CSA WA 682
    rs1823650691,2
    --68119099(+) TTTCTC/TGGGAA 1 -- int10--------
    rs171045501,2
    C,F--68119120(+) AGCCAG/ACTGAT 1 -- int16Minor allele frequency- A:0.11NA WA EA 500
    rs1163126411,2
    F--68119219(+) TTCCAT/CTCTTC 1 -- int11Minor allele frequency- C:0.08WA 118
    rs1874317591,2
    --68119294(+) GGTCCC/TCTGGG 1 -- int10--------
    rs1116977591,2
    C,F--68119534(+) GAGACG/AGAGTC 1 -- int11Minor allele frequency- A:0.50WA 2
    rs1495392821,2
    --68119541(+) AGTCTC/TGCTTT 1 -- int10--------
    rs1112696781,2
    C,F--68119577(+) GCCATC/TTCGGC 1 -- int11Minor allele frequency- T:0.50CSA 2

    HapMap Linkage Disequilibrium report for VTI1B (68113792 - 68141602 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for VTI1B:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2678403CNV Deletion23128226
    nsv521832CNV Loss19592680
    nsv902068CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing VTI1B
    DNA2.0 Custom Variant and Variant Library Synthesis for VTI1B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 603207    OMIM disorders: --


    Find genes that share disorders with VTI1B           About GenesLikeMe

    2 Novoseek inferred disease relationships for VTI1B gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tetanus 35.8 2 17567262 (1), 14973236 (1)
    insulin resistance 4.9 1 17848561 (1)

    Genetic Association Database (GAD): VTI1B
    Human Genome Epidemiology (HuGE) Navigator: VTI1B (1 document)

    Export disorders for VTI1B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for VTI1B gene, integrated from 10 sources (see all 107):
    (articles sorted by number of sources associating them with VTI1B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A human homolog can functionally replace the yeast vesicle-associated SNARE Vti1p in two vesicle transport pathways. (PubMed id 9446565)1, 2, 3, 9 Fischer von Mollard G. and Stevens T.H. (J. Biol. Chem. 1998)
    2. A hVti1 homologue: its expression depends on population doubling levels in both normal and SV40-transformed human fibroblasts. (PubMed id 9636656)1, 2, 3 Li H.-C.... Ide T. (Biochem. Biophys. Res. Commun. 1998)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Combinational soluble N-ethylmaleimide-sensitive factor attachment protein receptor proteins VAMP8 and Vti1b mediate fusion of antimicrobial and canonical autophagosomes with lysosomes. (PubMed id 20089838)1, 9 Furuta N....Amano A. (Mol. Biol. Cell 2010)
    5. Endosomal SNARE proteins regulate CFTR activity and trafficking in epithelial cells. (PubMed id 18570918)1, 9 Bilan F....Thoreau V. (Exp. Cell Res. 2008)
    6. The hairpin-type tail-anchored SNARE syntaxin 17 targets to autophagosomes for fusion with endosomes/lysosomes. (PubMed id 23217709)2 Itakura E.... Mizushima N. (Cell 2012)
    7. Comparative large scale characterization of plant versus mammal proteins reveals similar and idiosyncratic N-I+-acetylation features. (PubMed id 22223895)2 Bienvenut W.V....Giglione C. (amp 2012)
    8. Defective HIV-1 particle assembly in AP-3-deficient cells derived from patients with Hermansky-Pudlak syndrome type 2. (PubMed id 22875976)1 Liu L....Dong X. (J. Virol. 2012)
    9. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 10490 HGNC: 17793 AceView: VTI1B Ensembl:ENSG00000100568 euGenes: HUgn10490
    ECgene: VTI1B Kegg: 10490 H-InvDB: VTI1B

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for VTI1B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for VTI1B gene:
    Search GeneIP for patents involving VTI1B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for VTI1B   OriGene RNAi products in human, mouse, rat for VTI1B  
     OriGene qPCR primer pairs and template standards for VTI1B   OriGene Protein Over-expression Lysate for VTI1B  
     OriGene MassSpec something-or-other for VTI1B   OriGene clones in human, mouse for VTI1B  
     OriGene qSTAR qPCR primer pairs in human, mouse for VTI1B   OriGene Purified Protein for VTI1B  
     OriGene ORF clones in mouse, rat for VTI1B   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for VTI1B   OriGene Custom Protein Services for VTI1B  

     
     
     Block miRNA regulation of human, mouse, rat VTI1B using miScript Target Protectors SeqTarget long-range PCR primers for resequencing VTI1B
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat VTI1B Predesigned siRNA for gene silencing in human, mouse, rat VTI1B
     QuantiFast Probe-based Assays in human, mouse, rat VTI1B QuantiTect SYBR Green Assays in human, mouse, rat VTI1B
     Custom PCR Arrays for VTI1B Search Chromatin IP Primers for VTI1B
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat VTI1B  GeneGlobe Interaction Network for VTI1B
     Regulatory tfbs in VTI1B promoter
     GenScript Custom Purified and Recombinant Proteins Services for VTI1B GenScript cDNA clones with any tag delivered in your preferred vector for VTI1B
     GenScript Custom Assay Services for VTI1B GenScript Custom overexpressing Cell Line Services for VTI1B
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for VTI1B
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for VTI1B
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     VTI1B antibodies
     VTI1B proteins
     VTI1B lysates
     Antibodies for VTI1B
     See all of Abcam's Antibodies, Kits and Proteins for VTI1B
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for VTI1B
     Proteins for VTI1B
     Antibodies for VTI1B
     ELISAs for VTI1B
     CLIAs for VTI1B



     Browse ESI BIO Cell Lines and PureStem Progenitors for VTI1B
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VTI1B
     SwitchGear 3'UTR luciferase reporter plasmids for VTI1B
     SwitchGear Promoter luciferase reporter plasmids for VTI1B
     ThermoFisher Antibodies for VTI1B
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VTI1B
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for VTI1B
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for VTI1B
     LSBio Antibodies in human, mouse, rat for VTI1B
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Addgene plasmids for VTI1B
      Search eBioscience for proteins for VTI1B
      Search eBioscience for elisas for VTI1B
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      VTI1B gene at Home site.
    Version: 3.12.212 17 Sep 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4