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Aliases for VTI1A Gene

Aliases for VTI1A Gene

  • Vesicle Transport Through Interaction With T-SNAREs 1A 2 3 5
  • Vesicle Transport V-SNARE Protein Vti1-Like 2 3 4
  • Vti1-Rp2 3 4
  • Vesicle Transport Through Interaction With T-SNAREs Homolog 1A (Yeast) 2
  • SNARE Vti1a-Beta Protein 3
  • VTI1RP2 3
  • MMDS3 3
  • MVti1 3

External Ids for VTI1A Gene

Previous GeneCards Identifiers for VTI1A Gene

  • GC10P113440
  • GC10P114337
  • GC10P113871
  • GC10P114197
  • GC10P107834

Summaries for VTI1A Gene

Entrez Gene Summary for VTI1A Gene

  • The protein encoded by this gene is a member of the family of soluble N-ethylmaleimide-sensitive fusion protein-attachment protein receptors (SNAREs) that function in intracellular trafficking. This family member is involved in vesicular transport between endosomes and the trans-Golgi network. It is a vesicle-associated SNARE (v-SNARE) that interacts with target membrane SNAREs (t-SNAREs). Polymorphisms in this gene have been associated with binocular function, and also with susceptibility to colorectal and lung cancers. A recurrent rearrangement has been found between this gene and the transcription factor 7-like 2 (TCF7L2) gene in colorectal cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

GeneCards Summary for VTI1A Gene

VTI1A (Vesicle Transport Through Interaction With T-SNAREs 1A) is a Protein Coding gene. Diseases associated with VTI1A include megalencephalic leukoencephalopathy with subcortical cysts. Among its related pathways are Normal wtCFTR traffic / ER-to-Golgi and Vesicle-mediated transport. GO annotations related to this gene include SNARE binding and SNAP receptor activity. An important paralog of this gene is VTI1B.

UniProtKB/Swiss-Prot for VTI1A Gene

  • V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. Involved in vesicular transport from the late endosomes to the trans-Golgi network. Along with VAMP7, involved in an non-conventional RAB1-dependent traffic route to the cell surface used by KCNIP1 and KCND2. May be involved in increased cytokine secretion associated with cellular senescence.

Gene Wiki entry for VTI1A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VTI1A Gene

Genomics for VTI1A Gene

Regulatory Elements for VTI1A Gene

Promoters for VTI1A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around VTI1A on UCSC Golden Path with GeneCards custom track

Genomic Location for VTI1A Gene

Chromosome:
10
Start:
112,446,998 bp from pter
End:
112,855,364 bp from pter
Size:
408,367 bases
Orientation:
Plus strand

Genomic View for VTI1A Gene

Genes around VTI1A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
VTI1A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for VTI1A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VTI1A Gene

Proteins for VTI1A Gene

  • Protein details for VTI1A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96AJ9-VTI1A_HUMAN
    Recommended name:
    Vesicle transport through interaction with t-SNAREs homolog 1A
    Protein Accession:
    Q96AJ9
    Secondary Accessions:
    • A2A307
    • B4E137
    • Q5W0D7

    Protein attributes for VTI1A Gene

    Size:
    217 amino acids
    Molecular mass:
    25218 Da
    Quaternary structure:
    • Interacts with distinct SNARE complexes that contain either STX5 or STX6. Interacts with NAPA and, to a lesser extent, with NAPG. Identified in a complex containing STX6, STX12, VAMP4 and VTI1A.

    Alternative splice isoforms for VTI1A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for VTI1A Gene

Proteomics data for VTI1A Gene at MOPED

Post-translational modifications for VTI1A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for VTI1A Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for VTI1A (VTI1A)

No data available for DME Specific Peptides for VTI1A Gene

Domains & Families for VTI1A Gene

Gene Families for VTI1A Gene

Protein Domains for VTI1A Gene

Suggested Antigen Peptide Sequences for VTI1A Gene

Graphical View of Domain Structure for InterPro Entry

Q96AJ9

UniProtKB/Swiss-Prot:

VTI1A_HUMAN :
  • Belongs to the VTI1 family.
Family:
  • Belongs to the VTI1 family.
genes like me logo Genes that share domains with VTI1A: view

Function for VTI1A Gene

Molecular function for VTI1A Gene

UniProtKB/Swiss-Prot Function:
V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. Involved in vesicular transport from the late endosomes to the trans-Golgi network. Along with VAMP7, involved in an non-conventional RAB1-dependent traffic route to the cell surface used by KCNIP1 and KCND2. May be involved in increased cytokine secretion associated with cellular senescence.

Gene Ontology (GO) - Molecular Function for VTI1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000149 SNARE binding IBA --
genes like me logo Genes that share ontologies with VTI1A: view
genes like me logo Genes that share phenotypes with VTI1A: view

Animal Models for VTI1A Gene

MGI Knock Outs for VTI1A:

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for VTI1A Gene

Localization for VTI1A Gene

Subcellular locations from UniProtKB/Swiss-Prot for VTI1A Gene

Cytoplasmic vesicle. Golgi apparatus membrane; Single-pass type IV membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for VTI1A Gene COMPARTMENTS Subcellular localization image for VTI1A gene
Compartment Confidence
golgi apparatus 5
endosome 4
vacuole 4
cytosol 2
endoplasmic reticulum 1
extracellular 1
mitochondrion 1
nucleus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for VTI1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005768 endosome ISS --
GO:0005829 cytosol IMP 19224922
GO:0008021 synaptic vesicle ISS --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with VTI1A: view

Pathways & Interactions for VTI1A Gene

genes like me logo Genes that share pathways with VTI1A: view

Gene Ontology (GO) - Biological Process for VTI1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006623 protein targeting to vacuole IBA --
GO:0006896 Golgi to vacuole transport IBA --
GO:0090161 Golgi ribbon formation IMP 23677696
genes like me logo Genes that share ontologies with VTI1A: view

No data available for SIGNOR curated interactions for VTI1A Gene

Drugs & Compounds for VTI1A Gene

No Compound Related Data Available

Transcripts for VTI1A Gene

Unigene Clusters for VTI1A Gene

Vesicle transport through interaction with t-SNAREs 1A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for VTI1A Gene

No ASD Table

Relevant External Links for VTI1A Gene

GeneLoc Exon Structure for
VTI1A
ECgene alternative splicing isoforms for
VTI1A

Expression for VTI1A Gene

mRNA expression in normal human tissues for VTI1A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for VTI1A Gene

This gene is overexpressed in Nasal epithelium (53.9) and Fetal Brain (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for VTI1A Gene



SOURCE GeneReport for Unigene cluster for VTI1A Gene Hs.194554

genes like me logo Genes that share expression patterns with VTI1A: view

Protein tissue co-expression partners for VTI1A Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for VTI1A Gene

Orthologs for VTI1A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for VTI1A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia VTI1A 35
  • 94.15 (n)
  • 99.12 (a)
VTI1A 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia VTI1A 35
  • 94.47 (n)
  • 96.31 (a)
VTI1A 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Vti1a 35
  • 89.71 (n)
  • 94.93 (a)
Vti1a 16
Vti1a 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia VTI1A 35
  • 100 (n)
  • 100 (a)
VTI1A 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Vti1a 35
  • 90.63 (n)
  • 96.31 (a)
oppossum
(Monodelphis domestica)
Mammalia VTI1A 36
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia VTI1A 36
  • 90 (a)
OneToOne
chicken
(Gallus gallus)
Aves VTI1A 35
  • 84.11 (n)
  • 88.79 (a)
VTI1A 36
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 60 (a)
OneToMany
-- 36
  • 60 (a)
OneToMany
-- 36
  • 87 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.11914 35
vti1a 35
  • 78.97 (n)
  • 88.24 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.24211 35
zebrafish
(Danio rerio)
Actinopterygii vti1a 35
  • 75 (n)
  • 80.43 (a)
vti1a 36
  • 78 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6797 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009322 35
  • 51.2 (n)
  • 43.06 (a)
fruit fly
(Drosophila melanogaster)
Insecta Vti1 35
  • 48.15 (n)
  • 41.06 (a)
Vti1 36
  • 33 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea vti-1 35
  • 51.13 (n)
  • 43.2 (a)
vti-1 36
  • 38 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFL168W 35
  • 42.19 (n)
  • 25.12 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes VTI1 36
  • 29 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons SGR4 35
  • 47.76 (n)
  • 34.62 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU05959 35
  • 44.66 (n)
  • 33.98 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes vti1 35
  • 44.99 (n)
  • 34.48 (a)
Species with no ortholog for VTI1A:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for VTI1A Gene

ENSEMBL:
Gene Tree for VTI1A (if available)
TreeFam:
Gene Tree for VTI1A (if available)

Paralogs for VTI1A Gene

Paralogs for VTI1A Gene

(1) SIMAP similar genes for VTI1A Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with VTI1A: view

Variants for VTI1A Gene

Sequence variations from dbSNP and Humsavar for VTI1A Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs217140 -- 112,841,353(+) GTGTT(C/T)TGGAA intron-variant
rs172602 -- 112,832,891(-) CTACC(C/T)TGCAA intron-variant
rs307636 -- 112,829,181(+) ggctc(A/C)cgcct intron-variant
rs307637 -- 112,829,196(+) tccca(A/G)cactt intron-variant
rs545520 -- 112,837,336(-) CCAGG(A/T)ttttt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for VTI1A Gene

Variant ID Type Subtype PubMed ID
nsv7211 OTHER Inversion 18451855
nsv831990 CNV Loss 17160897
nsv831991 CNV Loss 17160897
esv271283 CNV Insertion 20981092
nsv526766 CNV Loss 19592680
nsv510234 CNV Loss 20534489
nsv525880 CNV Loss 19592680
nsv831992 CNV Loss 17160897

Variation tolerance for VTI1A Gene

Residual Variation Intolerance Score: 42.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.83; 17.36% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for VTI1A Gene

HapMap Linkage Disequilibrium report
VTI1A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VTI1A Gene

Disorders for VTI1A Gene

MalaCards: The human disease database

(1) MalaCards diseases for VTI1A Gene - From: GeneCards

Disorder Aliases PubMed IDs
megalencephalic leukoencephalopathy with subcortical cysts
  • vacuolating megalencephalic leukoencephalopathy with subcortical cysts
- elite association - COSMIC cancer census association via MalaCards
Search VTI1A in MalaCards View complete list of genes associated with diseases

Relevant External Links for VTI1A

Genetic Association Database (GAD)
VTI1A
Human Genome Epidemiology (HuGE) Navigator
VTI1A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
VTI1A
genes like me logo Genes that share disorders with VTI1A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for VTI1A Gene

Publications for VTI1A Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48 67
  2. A human homolog can functionally replace the yeast vesicle-associated SNARE Vti1p in two vesicle transport pathways. (PMID: 9446565) Fischer von Mollard G. … Stevens T.H. (J. Biol. Chem. 1998) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Endosomal sorting of VAMP3 is regulated by PI4K2A. (PMID: 25002402) JoviA8 M. … Balla T. (J. Cell. Sci. 2014) 3
  5. Trans-ethnic genome-wide association study of colorectal cancer identifies a new susceptibility locus in VTI1A. (PMID: 25105248) Wang H. … Le Marchand L. (Nat Commun 2014) 3

Products for VTI1A Gene

Sources for VTI1A Gene

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