Aliases for VTI1A Gene
External Ids for VTI1A Gene
Previous GeneCards Identifiers for VTI1A Gene
The protein encoded by this gene is a member of the family of soluble N-ethylmaleimide-sensitive fusion protein-attachment protein receptors (SNAREs) that function in intracellular trafficking. This family member is involved in vesicular transport between endosomes and the trans-Golgi network. It is a vesicle-associated SNARE (v-SNARE) that interacts with target membrane SNAREs (t-SNAREs). Polymorphisms in this gene have been associated with binocular function, and also with susceptibility to colorectal and lung cancers. A recurrent rearrangement has been found between this gene and the transcription factor 7-like 2 (TCF7L2) gene in colorectal cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
GeneCards Summary for VTI1A Gene
VTI1A (Vesicle Transport Through Interaction With T-SNAREs 1A) is a Protein Coding gene. Diseases associated with VTI1A include Megalencephalic Leukoencephalopathy With Subcortical Cysts. Among its related pathways are Normal wtCFTR traffic / ER-to-Golgi and Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics. GO annotations related to this gene include SNARE binding and SNAP receptor activity. An important paralog of this gene is VTI1B.
UniProtKB/Swiss-Prot for VTI1A Gene
V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. Involved in vesicular transport from the late endosomes to the trans-Golgi network. Along with VAMP7, involved in an non-conventional RAB1-dependent traffic route to the cell surface used by KCNIP1 and KCND2. May be involved in increased cytokine secretion associated with cellular senescence.