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Aliases for VTI1A Gene

Aliases for VTI1A Gene

  • Vesicle Transport Through Interaction With T-SNAREs 1A 2 3
  • Vesicle Transport V-SNARE Protein Vti1-Like 2 3 4
  • Vti1-Rp2 3 4
  • VTI1RP2 3 6
  • MMDS3 3 6
  • Vesicle Transport Through Interaction With T-SNAREs Homolog 1A (Yeast) 2
  • Vesicle Transport Through Interaction With T-SNAREs Homolog 1A 3
  • SNARE Vti1a-Beta Protein 3
  • MVti1 3

External Ids for VTI1A Gene

Previous GeneCards Identifiers for VTI1A Gene

  • GC10P113440
  • GC10P114337
  • GC10P113871
  • GC10P114197
  • GC10P107834

Summaries for VTI1A Gene

GeneCards Summary for VTI1A Gene

VTI1A (Vesicle Transport Through Interaction With T-SNAREs 1A) is a Protein Coding gene. Among its related pathways are Delta508-CFTR traffic / ER-to-Golgi in CF and Neuroscience. GO annotations related to this gene include SNAP receptor activity. An important paralog of this gene is VTI1B.

UniProtKB/Swiss-Prot for VTI1A Gene

  • V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. Involved in vesicular transport from the late endosomes to the trans-Golgi network. Along with VAMP7, involved in an non-conventional RAB1-dependent traffic route to the cell surface used by KCNIP1 and KCND2. May be involved in increased cytokine secretion associated with cellular senescence.

Gene Wiki entry for VTI1A Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VTI1A Gene

Genomics for VTI1A Gene

Regulatory Elements for VTI1A Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for VTI1A Gene

Start:
112,446,998 bp from pter
End:
112,855,364 bp from pter
Size:
408,367 bases
Orientation:
Plus strand

Genomic View for VTI1A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for VTI1A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VTI1A Gene

Proteins for VTI1A Gene

  • Protein details for VTI1A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96AJ9-VTI1A_HUMAN
    Recommended name:
    Vesicle transport through interaction with t-SNAREs homolog 1A
    Protein Accession:
    Q96AJ9
    Secondary Accessions:
    • A2A307
    • B4E137
    • Q5W0D7

    Protein attributes for VTI1A Gene

    Size:
    217 amino acids
    Molecular mass:
    25218 Da
    Quaternary structure:
    • Interacts with distinct SNARE complexes that contain either STX5 or STX6. Interacts with NAPA and, to a lesser extent, with NAPG. Identified in a complex containing STX6, STX12, VAMP4 and VTI1A.

    Alternative splice isoforms for VTI1A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for VTI1A Gene

Proteomics data for VTI1A Gene at MOPED

Post-translational modifications for VTI1A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for VTI1A Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for VTI1A (VTI1A)

No data available for DME Specific Peptides for VTI1A Gene

Domains for VTI1A Gene

Protein Domains for VTI1A Gene

Suggested Antigen Peptide Sequences for VTI1A Gene

Graphical View of Domain Structure for InterPro Entry

Q96AJ9

UniProtKB/Swiss-Prot:

VTI1A_HUMAN :
  • Q96AJ9
Family:
  • Belongs to the VTI1 family.
genes like me logo Genes that share domains with VTI1A: view

No data available for Gene Families for VTI1A Gene

Function for VTI1A Gene

Molecular function for VTI1A Gene

UniProtKB/Swiss-Prot Function: V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. Involved in vesicular transport from the late endosomes to the trans-Golgi network. Along with VAMP7, involved in an non-conventional RAB1-dependent traffic route to the cell surface used by KCNIP1 and KCND2. May be involved in increased cytokine secretion associated with cellular senescence.

Gene Ontology (GO) - Molecular Function for VTI1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000149 SNARE binding IBA --
GO:0005484 SNAP receptor activity IDA 15215310
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with VTI1A: view

Phenotypes for VTI1A Gene

genes like me logo Genes that share phenotypes with VTI1A: view

Animal Models for VTI1A Gene

MGI Knock Outs for VTI1A:

Animal Model Products

miRNA for VTI1A Gene

miRTarBase miRNAs that target VTI1A

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for VTI1A

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for VTI1A Gene

Localization for VTI1A Gene

Subcellular locations from UniProtKB/Swiss-Prot for VTI1A Gene

Cytoplasmic vesicle. Golgi apparatus membrane; Single-pass type IV membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for VTI1A Gene COMPARTMENTS Subcellular localization image for VTI1A gene
Compartment Confidence
golgi apparatus 5
cytosol 2
endoplasmic reticulum 1
extracellular 1
mitochondrion 1
nucleus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for VTI1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005768 endosome ISS --
GO:0005789 endoplasmic reticulum membrane IBA --
GO:0005794 Golgi apparatus IDA 19224922
GO:0008021 synaptic vesicle ISS --
genes like me logo Genes that share ontologies with VTI1A: view

Pathways for VTI1A Gene

genes like me logo Genes that share pathways with VTI1A: view

Pathways by source for VTI1A Gene

1 Cell Signaling Technology pathway for VTI1A Gene
1 KEGG pathway for VTI1A Gene
1 GeneGo (Thomson Reuters) pathway for VTI1A Gene

Gene Ontology (GO) - Biological Process for VTI1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006623 protein targeting to vacuole IBA --
GO:0006886 intracellular protein transport --
GO:0006888 ER to Golgi vesicle-mediated transport ISS --
GO:0006891 intra-Golgi vesicle-mediated transport IBA --
GO:0006896 Golgi to vacuole transport IBA --
genes like me logo Genes that share ontologies with VTI1A: view

Transcripts for VTI1A Gene

Unigene Clusters for VTI1A Gene

Vesicle transport through interaction with t-SNAREs 1A:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for VTI1A

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for VTI1A Gene

No ASD Table

Relevant External Links for VTI1A Gene

GeneLoc Exon Structure for
VTI1A
ECgene alternative splicing isoforms for
VTI1A

Expression for VTI1A Gene

mRNA expression in normal human tissues for VTI1A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for VTI1A Gene

SOURCE GeneReport for Unigene cluster for VTI1A Gene Hs.194554

genes like me logo Genes that share expressions with VTI1A: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for VTI1A Gene

Orthologs for VTI1A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for VTI1A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia VTI1A 35
  • 100 (n)
  • 100 (a)
VTI1A 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia VTI1A 35
  • 94.15 (n)
  • 99.12 (a)
VTI1A 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia VTI1A 35
  • 94.47 (n)
  • 96.31 (a)
VTI1A 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Vti1a 35
  • 89.71 (n)
  • 94.93 (a)
Vti1a 16
Vti1a 36
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia VTI1A 36
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia VTI1A 36
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Vti1a 35
  • 90.63 (n)
  • 96.31 (a)
chicken
(Gallus gallus)
Aves VTI1A 35
  • 84.11 (n)
  • 88.79 (a)
VTI1A 36
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 60 (a)
OneToMany
-- 36
  • 60 (a)
OneToMany
-- 36
  • 87 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia Xl.24211 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.11914 35
vti1a 35
  • 78.97 (n)
  • 88.24 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6797 35
zebrafish
(Danio rerio)
Actinopterygii vti1a 35
  • 75 (n)
  • 80.43 (a)
vti1a 36
  • 78 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009322 35
  • 51.2 (n)
  • 43.06 (a)
fruit fly
(Drosophila melanogaster)
Insecta Vti1 35
  • 48.15 (n)
  • 41.06 (a)
Vti1 36
  • 33 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea vti-1 35
  • 51.13 (n)
  • 43.2 (a)
vti-1 36
  • 38 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFL168W 35
  • 42.19 (n)
  • 25.12 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes VTI1 36
  • 29 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons SGR4 35
  • 47.76 (n)
  • 34.62 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU05959 35
  • 44.66 (n)
  • 33.98 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes vti1 35
  • 44.99 (n)
  • 34.48 (a)
Species with no ortholog for VTI1A:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for VTI1A Gene

ENSEMBL:
Gene Tree for VTI1A (if available)
TreeFam:
Gene Tree for VTI1A (if available)

Paralogs for VTI1A Gene

Paralogs for VTI1A Gene

Selected SIMAP similar genes for VTI1A Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with VTI1A: view

Variants for VTI1A Gene

Sequence variations from dbSNP and Humsavar for VTI1A Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs172602 -- 112,832,891(-) CTACC(C/T)TGCAA intron-variant
rs217140 -- 112,841,353(+) GTGTT(C/T)TGGAA intron-variant
rs477167 -- 112,851,745(-) AATGC(C/G)TCTCC intron-variant
rs478854 -- 112,816,015(-) TCAGC(A/C)AAAAA utr-variant-3-prime, intron-variant
rs482358 -- 112,855,132(+) GACCC(A/G)GGATG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for VTI1A Gene

Variant ID Type Subtype PubMed ID
nsv7211 OTHER Inversion 18451855
nsv831990 CNV Loss 17160897
nsv831991 CNV Loss 17160897
esv271283 CNV Insertion 20981092
nsv526766 CNV Loss 19592680
nsv510234 CNV Loss 20534489
nsv525880 CNV Loss 19592680
nsv831992 CNV Loss 17160897

Relevant External Links for VTI1A Gene

HapMap Linkage Disequilibrium report
VTI1A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VTI1A Gene

Disorders for VTI1A Gene

(1) OMIM Diseases for VTI1A Gene (614316)

Relevant External Links for VTI1A

Genetic Association Database (GAD)
VTI1A
Human Genome Epidemiology (HuGE) Navigator
VTI1A
genes like me logo Genes that share disorders with VTI1A: view

No data available for UniProtKB/Swiss-Prot for VTI1A Gene

Publications for VTI1A Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  2. A human homolog can functionally replace the yeast vesicle-associated SNARE Vti1p in two vesicle transport pathways. (PMID: 9446565) Fischer von Mollard G. … Stevens T.H. (J. Biol. Chem. 1998) 2 3
  3. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A. … Goate A. (Am. J. Hum. Genet. 2006) 3 48
  4. Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study. (PMID: 17975119) Shiffman D. … Psaty B.M. (Arterioscler. Thromb. Vasc. Biol. 2008) 3 48
  5. A syntaxin 10-SNARE complex distinguishes two distinct transport routes from endosomes to the trans-Golgi in human cells. (PMID: 18195106) Ganley I.G. … Pfeffer S.R. (J. Cell Biol. 2008) 3 4

Products for VTI1A Gene

Sources for VTI1A Gene

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