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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

VTI1A Gene

protein-coding   GIFtS: 55
GCID: GC10P114197

Vesicle Transport Through Interaction With T-SNAREs 1A

(Previous name: vesicle transport through interaction with t-SNAREs homolog...)
Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Vesicle Transport Through Interaction With T-SNAREs 1A1 2     MVti12
Vesicle Transport V-SNARE Protein Vti1-Like 22 3     VTI1RP22
Vti1-rp22 3     SNARE Vti1a-Beta Protein2
Vesicle Transport Through Interaction With T-SNAREs Homolog 1A (Yeast)1     Vesicle Transport Through Interaction With T-SNAREs Homolog 1A2
MMDS32     

External Ids:    HGNC: 177921   Entrez Gene: 1431872   Ensembl: ENSG000001515327   OMIM: 6143165   UniProtKB: Q96AJ93   

Export aliases for VTI1A gene to outside databases

Previous GC identifers: GC10P113440 GC10P114337 GC10P113871 GC10P107834


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for VTI1A Gene: 
VTI1A (vesicle transport through interaction with t-SNAREs 1A) is a protein-coding gene. Diseases associated with VTI1A include myocardial infarction, and alzheimer's disease, and among its related super-pathways are Clathrin-dependent protein traffic and Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics. GO annotations related to this gene include SNAP receptor activity. An important paralog of this gene is VTI1B.

UniProtKB/Swiss-Prot: VTI1A_HUMAN, Q96AJ9
Function: V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target
membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to
promote fusion of the lipid bilayers. Involved in vesicular transport from the late endosomes to the trans-Golgi
network. Along with VAMP7, involved in an non-conventional RAB1-dependent traffic route to the cell surface used
by KCNIP1 and KCND2. May be involved in increased cytokine secretion associated with cellular senescence

Gene Wiki entry for VTI1A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NT_030059.13  NC_018921.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the VTI1A gene promoter:
         AML1a   MyoD   HNF-3beta   GATA-1   C/EBPalpha   RORalpha1   FOXC1   Sox9   En-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidVTI1A promoter sequence
   Search SABiosciences Chromatin IP Primers for VTI1A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat VTI1A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q25.2   Ensembl cytogenetic band:  10q25.2   HGNC cytogenetic band: 10q25.2

VTI1A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
VTI1A gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P114197:  view genomic region     (about GC identifiers)

Start:
114,206,756 bp from pter      End:
114,578,503 bp from pter
Size:
371,748 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: VTI1A_HUMAN, Q96AJ9 (See protein sequence)
Recommended Name: Vesicle transport through interaction with t-SNAREs homolog 1A  
Size: 217 amino acids; 25218 Da
Subunit: Interacts with distinct SNARE complexes that contain either STX5 or STX6 (By similarity). Interacts with
NAPA and, to a lesser extent, with NAPG (By similarity). Identified in a complex containing STX6, STX12, VAMP4
and VTI1A (By similarity)
Subcellular location: Cytoplasmic vesicle. Golgi apparatus membrane; Single-pass type IV membrane protein (By
similarity)
Secondary accessions: A2A307 B4E137 Q5W0D7
Alternative splicing: 2 isoforms:  Q96AJ9-2   Q96AJ9-1   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for VTI1A: NX_Q96AJ9

Explore proteomics data for VTI1A at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96AJ9

  • VTI1A Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    VTI1A Protein Expression
    REFSEQ proteins: NP_660207.2  
    ENSEMBL proteins: 
     ENSP00000395017   ENSP00000376792  

    Human Recombinant Protein Products for VTI1A: 
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    Sino Biological Recombinant Protein for VTI1A
    Sino Biological Cell Lysate for VTI1A 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for VTI1A 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IEA--
    GO:0005794Golgi apparatus IDA19224922
    GO:0016020membrane ----
    GO:0016021integral to membrane IEA--
    GO:0016023cytoplasmic membrane-bounded vesicle IEA--

    VTI1A for ontologies           About GeneDecksing



    VTI1A Antibody Products: 
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    LSBio Antibodies in human, mouse, rat for VTI1A 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR000727 T_SNARE_dom
     IPR010989 t-SNARE
     IPR007705 Vesicle_trsprt_v-SNARE_N

    Graphical View of Domain Structure for InterPro Entry Q96AJ9

    ProtoNet protein and cluster: Q96AJ9

    UniProtKB/Swiss-Prot: VTI1A_HUMAN, Q96AJ9
    Similarity: Belongs to the VTI1 family


    VTI1A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: VTI1A_HUMAN, Q96AJ9
    Function: V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target
    membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to
    promote fusion of the lipid bilayers. Involved in vesicular transport from the late endosomes to the trans-Golgi
    network. Along with VAMP7, involved in an non-conventional RAB1-dependent traffic route to the cell surface used
    by KCNIP1 and KCND2. May be involved in increased cytokine secretion associated with cellular senescence

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005484SNAP receptor activity IDA15215310
    GO:0005515protein binding ----
         
    VTI1A for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for VTI1A:
     Synthetic lethal with Ras 

         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Vti1a):
     cellular  mortality/aging  nervous system  normal  vision/eye 

    VTI1A for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Vti1atm1Gfvm for VTI1A

       inGenious Targeting Laboratory - Custom generated mouse model solutions for VTI1A 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for VTI1A

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for VTI1A 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for VTI1A 

    miRNA
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    hsa-miR-576-3p hsa-miR-607 hsa-miR-15a hsa-miR-218-1* hsa-miR-938 hsa-miR-550a* hsa-miR-3613-3p hsa-miR-200b
    SwitchGear 3'UTR luciferase reporter plasmidVTI1A 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VTI1A


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for VTI1A About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Clathrin-dependent protein traffic
    Transport Clathrin-coated vesicle cycle0.66
    2Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics
    SNARE interactions in vesicular transport0.40
    3Neuroscience
    Neuroscience

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for VTI1A
        Neuroscience

    1 GeneGo (Thomson Reuters) Pathway for VTI1A
        Transport Clathrin-coated vesicle cycle



    1         Kegg Pathway  (Kegg details for VTI1A):
        SNARE interactions in vesicular transport


    VTI1A for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for VTI1A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/46 Interacting proteins for VTI1A (Q96AJ92, 3 ENSP000003767924) via UniProtKB, MINT, STRING, and/or I2D (see all 46)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    STX6O437522, 3, ENSP000002583014MINT-4052274 MINT-4052302 MINT-4052327 MINT-4052351 I2D: score=1 STRING: ENSP00000258301
    VAMP4O753792, 3, ENSP000002361924MINT-4052274 MINT-4052302 MINT-4052327 MINT-4052351 I2D: score=1 STRING: ENSP00000236192
    STX12Q86Y822, ENSP000003630544MINT-4052274 MINT-4052302 MINT-4052327 MINT-4052351 STRING: ENSP00000363054
    NAPBQ9H1153, ENSP000003662254I2D: score=2 STRING: ENSP00000366225
    STX8Q9UNK03, ENSP000003052554I2D: score=2 STRING: ENSP00000305255
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006886intracellular protein transport IEA--
    GO:0016192vesicle-mediated transport ----
    GO:0042147retrograde transport, endosome to Golgi IMP19224922

    VTI1A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for VTI1A

    Search CenterWatch for drugs/clinical trials and news about VTI1A

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for VTI1A gene: 
    NM_145206.2  

    Unigene Cluster for VTI1A:

    Vesicle transport through interaction with t-SNAREs 1A
    Hs.194554  [show with all ESTs]
    Unigene Representative Sequence: NM_145206
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000483122(uc001kzx.3) ENST00000472892 ENST00000489142 ENST00000432306(uc001kzy.3)
    ENST00000393077(uc001kzz.3) ENST00000496445 ENST00000494728 ENST00000489357
    ENST00000480057

    miRNA
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    hsa-miR-576-3p hsa-miR-607 hsa-miR-15a hsa-miR-218-1* hsa-miR-938 hsa-miR-550a* hsa-miR-3613-3p hsa-miR-200b
    SwitchGear 3'UTR luciferase reporter plasmidVTI1A 3' UTR sequence
    Inhib. RNA
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat VTI1A
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    Additional mRNA sequence: 

    AK095476.1 AK126483.1 AK303646.1 BC017052.1 BC064614.1 BC067241.1 

    13 DOTS entries:

    DT.407866  DT.75173221  DT.100020000  DT.40111075  DT.100011450  DT.100746893  DT.424257  DT.97823573 
    DT.40118539  DT.102842209  DT.121217115  DT.303142  DT.86836587 

    24/124 AceView cDNA sequences (see all 124):

    BX403250 BX101669 BQ653183 CR607772 BF805294 AA745649 BM810319 BQ959536 
    AI199267 NM_145206 BF511098 AL712878 CA433670 CR618926 AL581041 AI745313 
    BG230762 AI797732 BM760466 AK126483 BX358480 BC017052 BI830707 AA326353 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    VTI1A expression in normal human tissues (normalized intensities)      VTI1A embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    VTI1A Expression
    About this image


    VTI1A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/22 selected tissues (see all 22) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Epithelium (Uncategorized)    fully expand to see all 4 entries
             vagina ; squamous epithelial cells   
     
     Blood (Hematopoietic System)    fully expand to see all 3 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
             monocyte-derived macrophage   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 3 entries
             colon ; peripheral nerve/ganglion   
     
     Tonsil (Hematopoietic System)    fully expand to see all 3 entries
             tonsil ; squamous epithelial cells   

    See VTI1A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for VTI1A

    SOURCE GeneReport for Unigene cluster: Hs.194554
        SABiosciences Custom PCR Arrays for VTI1A
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VTI1A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for VTI1A gene from 10/23 species (see all 23)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Vti1a1 , 5 vesicle transport through interaction with t-SNAREs homolog 1A (yeast) less1, 5 89.71(n)1
    94.93(a)1
      19 (51.35 cM)5
    536111  NM_016862.31  NP_058558.11 
     553163515 
    chicken
    (Gallus gallus)
    Aves VTI1A1 vesicle transport through interaction with t-SNAREs homolog 1A (yeast) less 83.72(n)
    88.37(a)
      770885  XM_001233033.2  XP_001233034.1 
    lizard
    (Anolis carolinensis)
    Reptilia VTI1A6
    --
    Uncharacterized protein
    77(a)
    60(a)
    1 ↔ 1
    possible ortholog
    GL343204.1(1860719-1871534)
    AAWZ02036108(13030-31699)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.242112 Xenopus laevis cDNA clone IMAGE6880746, partial cds less 78.87(n)    BC054311.1 
    zebrafish
    (Danio rerio)
    Actinopterygii vti1a1 vesicle transport through interaction with t-SNAREs homolog 1A (yeast) less 75(n)
    80.43(a)
      567385  NM_001034980.1  NP_001030152.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Vti11 CG3279-PA 47.44(n)
    38.94(a)
      38085  NM_138209.3  NP_612053.1 
    worm
    (Caenorhabditis elegans)
    Secernentea vti-11 Protein VTI-1 51.31(n)
    43.63(a)
      178397  NM_070380.2  NP_502781.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes VTI11 Vti1p 45.3(n)
    33.01(a)
      855237   NP_013924.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons SGR41 vesicle transport v-SNARE 11 48.08(n)
    35.1(a)
      833947  NM_123313.4  NP_198767.1 
    rice
    (Oryza sativa)
    Liliopsida Os01g07073001 hypothetical protein 45.17(n)
    30.84(a)
      4327678  NM_001050556.1  NP_001044021.1 


    ENSEMBL Gene Tree for VTI1A (if available)
    TreeFam Gene Tree for VTI1A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for VTI1A gene
    VTI1B2  
    1 SIMAP similar gene for VTI1A using alignment to 1 protein entry:     VTI1A_HUMAN:
    VTI1B

    VTI1A for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/6900 SNPs in VTI1A are shown (see all 6900)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1469815111,2
    --114208674(+) ACTTAG/TACCCC 1 -- int10--------
    rs1384390371,2
    --114208707(+) TTAGTC/TCTGGA 1 -- int10--------
    rs1176690211,2
    F--114208778(+) CCAAGG/ATAGTA 1 -- int11Minor allele frequency- A:0.01EA 120
    rs1896257201,2
    --114208825(+) GTCGAA/CAGTGG 1 -- int10--------
    rs1913753491,2
    --114209133(+) CAGATC/TGTGTT 1 -- int10--------
    rs1418814751,2
    --114209247(+) TGGCTC/TATGCC 1 -- int10--------
    rs1844487491,2
    C--114209287(+) CAGACA/GGATCA 1 -- int10--------
    rs1897271121,2
    --114209338(+) GAAACC/TCTGTC 1 -- int10--------
    rs2000591901,2
    --114209523(+) ATAAA-/TTTAAA 1 -- int10--------
    rs412926181,2
    C,F--114209526(+) AAATTA/TAAAAA 1 -- int16Minor allele frequency- T:0.24WA NA EA 364

    HapMap Linkage Disequilibrium report for VTI1A (114206756 - 114456756 bp, first 250kb of VTI1A)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for VTI1A:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv271283CNV Insertion20981092
    nsv831992CNV Loss17160897
    nsv525880CNV Loss19592680
    nsv831991CNV Loss17160897
    nsv831990CNV Loss17160897
    nsv526766CNV Loss19592680
    nsv510234CNV Loss20534489
    nsv7211OTHER Inversion18451855

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 614316    OMIM disorders: --

    4 diseases for VTI1A:    About MalaCards
    myocardial infarction    alzheimer's disease    adenocarcinoma    neuronitis


    VTI1A for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): VTI1A
    Human Genome Epidemiology (HuGE) Navigator: VTI1A (5 documents)

    Export disorders for VTI1A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for VTI1A gene, integrated from 9 sources (see all 28):
    (articles sorted by number of sources associating them with VTI1A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    2. Common variants in 22 loci are associated with QRS du ration and cardiac ventricular conduction. (PubMed id 21076409)1, 4 Sotoodehnia N....Arking D.E. (2010)
    3. Gene variants associated with ischemic stroke: the cardiovascular health study. (PubMed id 19023099)1, 4 Luke M.M....Psaty B.M. (2009)
    4. A VAMP7/Vti1a SNARE complex distinguishes a non-conventional traffic route to the cell surface used by KChIP1 and Kv4 potassium channels. (PubMed id 19138172)1, 2 Flowerdew S.E. and Burgoyne R.D. (2009)
    5. Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study. (PubMed id 17975119)1, 4 Shiffman D....Psaty B.M. (2008)
    6. A syntaxin 10-SNARE complex distinguishes two distinct transport routes from endosomes to the trans-Golgi in human cells. (PubMed id 18195106)1, 2 Ganley I.G....Pfeffer S.R. (2008)
    7. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (2006)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. A human homolog can functionally replace the yeast vesicle-associated SNARE Vti1p in two vesicle transport pathways. (PubMed id 9446565)1, 3 Fischer von Mollard G. and Stevens T.H. (1998)
    10. A genome-wide association study of brain lesion distri bution in multiple sclerosis. (PubMed id 23412934)1 Gourraud P.A....Baranzini S.E. (2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Aliases
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 143187 HGNC: 17792 AceView: VTI1A Ensembl:ENSG00000151532 euGenes: HUgn143187
    ECgene: VTI1A Kegg: 143187 H-InvDB: VTI1A

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for VTI1A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for VTI1A gene:
    Search GeneIP for patents involving VTI1A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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