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Aliases & Descriptions for VTCN1 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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User Feedback Aliases & Descriptions V-set domain containing T cell activation inhibitor 11 2 T-cell costimulatory molecule B7x2 3 B7H41 2 3 T cell costimulatory molecule B7x2 FLJ224181 2 PRO12912 B7-H41 2 V-set domain-containing T-cell activation inhibitor 12 B7X1 2 VCTN12 B7S11 2 RP11-229A19.42 Immune costimulatory protein B7-H42 3 Protein B7S13 B7h.52 3
Search outside databases for aliases for VTCN1 genePrevious GC identifer: GC01M117399
Summaries for VTCN1 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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User Feedback Entrez Gene summary for VTCN1 : B7H4 belongs to the B7 family (see CD80; MIM 112203) of costimulatory proteins. These proteins are expressed on the surface of antigen-presenting cells and interact with ligands (e.g., CD28; MIM 186760) on T lymphocytes.(supplied by OMIM) UniProtKB/Swiss-Prot: VTCN1_HUMAN, Q7Z7D3 Function : Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokineproduction and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor-associated antigen-specific T-cell immunity. Involved in promoting epithelial cell transformation Gene Wiki entry for VTCN1
Genomic Views for VTCN1 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC and
Ensembl (release 56) ,
Regulatory elements and Epigenetics data according to
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User Feedback Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the VTCN1 gene upstream (promoter) region :C/EBPalpha CHOP-10 NF-kappaB1 NF-kappaB NF-kappaB2 Tal-1beta ITF-2 c-Rel NRSF form 1 NRSF form 2 Epigenetics: Search SABiosciences Methyl-Profiler DNA Methylation qPCR Primer Assays for VTCN1 Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 1p13.1 Ensembl cytogenetic band: 1p13.1 HGNC cytogenetic band: 1p12 VTCN1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure
GeneLoc location for GC01M117686: view genomic region
(about GC identifiers )
Start:
117,686,209 bp from pter
End:
117,753,556 bp from pter
Size:
67,348 bases
Orientation:
minus strand
RefSeq DNA sequence: NC_000001.10 NT_032977.9 Proteins for VTCN1 gene
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene ,
Novus Biologicals , and/or
Sino Biological ,
Biochemical Assays by
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 May 2010 and
Entrez Gene ,
Antibodies by
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abnova ,
OriGene ,
Novus Biologicals , and/or
Epitomics )
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User Feedback UniProtKB/Swiss-Prot: VTCN1_HUMAN, Q7Z7D3 (See
protein sequence )Recommended Name: V-set domain-containing T-cell activation inhibitor 1 precursor Size : 282 amino acids; 30878 Da
Subcellular location : Cell membrane; Single-pass type I membrane protein (Potential). Note=Expressed at the cellsurface. A soluble form has also been detected
Miscellaneous : May serve as a predictive marker for renal cell carcinoma
Caution : The mouse ortholog has been shown (PubMed:12818166) to be a GPI-anchored protein but the Gly residue which ispredicted to be the modified site in mouse and rat is not conserved in human
Secondary accessions : Q0GN76 Q45VN0 Q5WPZ3 Q9H6B2Alternative splicing : 3 isoforms : Q7Z7D3-1 Q7Z7D3-2 Q7Z7D3-3 Post-translational modifications:
N-glycosylated1
REFSEQ proteins: NP_078902.2 ENSEMBL proteins: ENSP00000358470 ENSP00000351899 ENSP00000328168 ENSP00000358468 Human Recombinant Proteins 2 Gene Ontology (GO) cellular component terms (GO ID links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0005886 plasma membrane
IEA -- GO:0016021 integral to membrane
IEA --
About this table
VTCN1 for ontologies About GeneDecksing Antibodies for VTCN1: Assays for VTCN1:
Protein
Domains/ Families for VTCN1 gene(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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VTCN1 for domains About GeneDecksing 4 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q7Z7D3 ProtoNet protein and cluster: Q7Z7D3
1 Blocks protein family : IPB013106 Immunoglobulin V-set UniProtKB/Swiss-Prot: VTCN1_HUMAN, Q7Z7D3 Similarity : Belongs to the immunoglobulin superfamily. BTN/MOG familySimilarity : Contains 2 Ig-like V-type (immunoglobulin-like) domains
Gene Function for VTCN1 gene
(According to MGI May 08 2010, UniProtKB ,
IUBMB ,and/or Genatlas ,
shRNA from
OriGene ,
Sigma-Aldrich , RNAi from
Millipore ,
Abnova ,
siRNAs from
Applied Biosystems ,
Sigma-Aldrich , Clones from
Millipore ,
Sigma-Aldrich ,
OriGene ,
Sino Biological ,
Ontologies according to Gene Ontology Consortium 01 May 2010 via
Entrez Gene .)
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User Feedback UniProtKB/Swiss-Prot: VTCN1_HUMAN, Q7Z7D3 Function : Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokineproduction and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor-associated antigen-specific T-cell immunity. Involved in promoting epithelial cell transformation Induction : Up-regulated by IL-6 and IL-10 and inhibited by GM-CSF and IL-4 on antigen-presenting cells (APCs)
1 Gene Ontology (GO) molecular function term (GO ID links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0005102 receptor binding
-- --
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VTCN1 for ontologies About GeneDecksing Animal Models: 4 MGI mutant phenotypes (inferred from 4 alleles ) (MGI details for Vtcn1) :
VTCN1 for phenotypes About GeneDecksing Pathways & Interactions for VTCN1 gene
(Pathways according to
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
Applied Biosystems GeneAssist ,
KEGG
and/or UniProtKB ,
(map by GeneGo ),
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 May 2010 via
Entrez Gene) .
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User Feedback Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for VTCN1 2 Gene Ontology (GO) biological process terms (GO ID links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0006955 immune response
IEA -- GO:0050868 negative regulation of T cell activation
-- --
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VTCN1 for ontologies About GeneDecksing
Drugs & Compounds for VTCN1 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
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VTCN1 for compounds About GeneDecksing Browse Tocris compounds for VTCN1 4 Novoseek chemical compound relationships for VTCN1 gene
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Transcripts for VTCN1 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 223 Homo sapiens; Apr 2 2010) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
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siRNAs from Applied Biosystems ,
Sigma-Aldrich ,
shRNA from
Sigma-Aldrich ,
OriGene ,
microRNA from SABiosciences ,
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User Feedback Assays: Applied Biosystems TaqMan® Gene Expression Assays: NM_024626 Clones: Origene GFP tagged cDNA clones in CMV expression vector: VTCN1 Origene Myc/DDK tagged cDNA clones in CMV expression vector: VTCN1 Origene untagged cDNA clones in CMV expression vector: VTCN1
Primers: Origene genome-wide validated SYBR primer pairs: VTCN1 SABiosciences RT2 qPCR Primer Assay for VTCN1: PPH09043A
REFSEQ mRNAs for VTCN1 gene: NM_024626.2
Additional cDNA sequence: AK225413.1 AK303466.1 AK310812.1 AY280972.1 AY346100.1 AY358352.1 AY442303.1 BC065717.1 BC074729.2 BX648021.1 CR603772.1 DQ103757.1 DQ836392.1
3 DOTS entries : DT.100697933 DT.92070437 DT.312331
24/70 AceView cDNA sequences (see all 70
):
AY280972 AK026071 BM981657 CA311913 CR603772 AI682137 AI539195 CB852239 AI686571 AA404609 AI683712 NM_024626 CB241729 AI684143 AA291512 AI638559 AA171844 AI858190 BC074729 AW470108 BU680630 BE741325 BX499180 AI539668
highest scoring ESTs for VTCN1 :AA333549 AI799522 AY280972 BC065717 BF680206 BX499180 BX648021 AA075579 AA075632 AA171844 Unigene Cluster for VTCN1:
V-set domain containing T cell activation inhibitor 1 Hs.546434 [show with all ESTs ] Unigene Representative Sequence: BX648021 GeneLoc Exon Structure 4 Alternative Splicing Database (ASD) splice patterns (SP) for VTCN1 ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c SP1 :     -                     SP2 :     -     -                 SP3 :         -                 SP4 :     -     -   -              
About this scheme ECgene alternative splicing isoforms for VTCN1 6 Ensembl transcripts including schematic representations : ENST00000488493
ENST00000369458
ENST00000359008
ENST00000463461
ENST00000328189
ENST00000369456
Expression for VTCN1 gene
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 223 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems ,
Primers from
OriGene and/or
SABiosciences
)
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User Feedback VTCN1 expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for VTCN1 1 / 2 / 3
4 probe-sets matching VTCN1 gene
Affymetrix probe-set
Array
GeneAnnot data
GeneNote data
GeneTide data
# genes
Sensitivity
Specificity
Correlation
Length
Gb_Accession
Consensus
Uniqueness
Score
Rank
45137_at2 , 3
U95-B
1
1.00
1.00
0.99
0.77
AA075632
0.60
1.00
0.82
1
72384_at2 , 3
U95-D
2
1.00
0.91
0.94
1.28
AI799522
0.80
1.00
0.91
1
219768_at2 , 3
U133-A
1
1.00
1.00
--
--
NM_024626
0.40
1.00
0.76
1
219768_at2
U133Plus2
1
1.00
1.00
--
--
--
--
--
--
--
About this table
VTCN1 for expression About GeneDecksing Data from
Genenote  
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: TTGTTATAGA SOURCE GeneReport for Unigene cluster: Hs.546434 UniProtKB/Swiss-Prot: VTCN1_HUMAN, Q7Z7D3 Tissue specificity : Overexpressed in breast, ovarian, endometrial, renal cell (RCC) and non-small-cell lung cancers(NSCLC). Expressed on activated T- and B-cells, monocytes and dendritic cells, but not expressed in most normal tissues (at protein level). Widely expressed, including in kidney, liver, lung, ovary, placenta, spleen and testis
Primers: Origene genome-wide validated SYBR primer pairs: VTCN1 SABiosciences RT2 qPCR Primer Assay for VTCN1: PPH09043A
Orthologs for VTCN1 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI May 08 2010,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for VTCN1 gene from 5/6 species (see all 6
)
About this table Species with no ortholog for VTCN1 ENSEMBL Gene Tree for VTCN1 Paralogs for VTCN1 gene (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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User Feedback Paralogs for VTCN1 gene HHLA2 2
VTCN1 for paralogs About GeneDecksing
Genomic Variants for VTCN1 gene (SNPs according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for VTCN1 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for VTCN1: --
Disorders & Mutations for VTCN1 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
Novoseek , PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
LSDB, HGMD, GAD ,
HuGE Navigator ,
BCGD,
and/or TGDB .)
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VTCN1 for disorders About GeneDecksing
OMIM: 608162 10/21 Novoseek disease relationships for VTCN1 gene (see all 21
)
About this table Human Genome Epidemiology Navigator: VTCN1 (2 documents)
Medical News for VTCN1 gene (Possibly Related Articles in
Doctor's Guide )
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User Feedback --
Publications for VTCN1 gene (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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User Feedback 10/32 PubMed articles for VTCN1 gene (see all 32
): B7-H4, a molecule of the B7 family, negatively regulates T cell immunity. (PubMed id 12818165) 1, 2, 3 , 4 Sica G.L....Chen L. (2003) B7-H4 expression identifies a novel suppressive macrophage population in human ovarian carcinoma. (PubMed id 16606666) 1, 3 , 4 Kryczek I....Zou W. (2006) The immunomodulatory protein B7-H4 is overexpressed in breast and ovarian cancers and promotes epithelial cell transformation. (PubMed id 15878339) 1, 3 , 4 Salceda S....Papkoff J. (2005) Cutting edge: induction of B7-H4 on APCs through IL-10: novel suppressive mode for regulatory T cells. (PubMed id 16785496) 1, 3 , 4 Kryczek I....Zou W. (2006) B7-H4 (DD-O110) is overexpressed in high risk uterine endometrioid adenocarcinomas and inversely correlated with tumor T-cell infiltration. (PubMed id 17509674) 3 , 4 Miyatake T....Shroyer K.R. (2007) B7-H4 expression in renal cell carcinoma and tumor vasculature: associations with cancer progression and survival. (PubMed id 16798883) 3 , 4 Krambeck A.E....Kwon E.D. (2006) B7S1, a novel B7 family member that negatively regulates T cell activation. (PubMed id 12818166) 2, 3 Prasad D.V....Dong C. (2003) Genomic organization and expression analysis of B7-H4, an immune inhibitory molecule of the B7 family. (PubMed id 14568939) 3 , 4 Choi I.H....Chen L. (2003) B7x: a widely expressed B7 family member that inhibits T cell activation. (PubMed id 12920180) 3 , 4 Zang X.... Allison J.P. (2003) The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309) 3 , 4 Clark H.F....Gray A. (2003)
Search for VTCN1 gene
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Genome Databases showing VTCN1 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
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Other Databases showing VTCN1 gene
(According to HUGE )
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Specialized Databases showing VTCN1 gene (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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User Feedback Patent Information for VTCN1 gene: Search GeneIP for patents involving VTCN1 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search Services for VTCN1 gene (Reagents available from Applied Biosystems , Antibodies and assays by Cell
Signaling Technology , Novus Biologicals ,Epitomics , Sigma-Aldrich , R&D Systems , SABiosciences , Millipore , Abnova , Clones available from OriGene , Sigma-Aldrich , Sino Biological , Drugs and/or compounds by Sigma-Aldrich , Enzo Life Sciences , and/or Tocris Bioscience )About This Section
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