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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

VTCN1 Gene

protein-coding   GIFtS: 51
GCID: GC01M117686

V-set domain containing T cell activation inhibitor 1
 Explore 19 diseases affiliated with
VTCN1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for VTCN1    

Aliases
for VTCN1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
V-Set Domain Containing T Cell Activation Inhibitor 11 2     VCTN12 5
B7H41 2 3 5     FLJ224181
B7S11 2 5     PRO12912
B7X1 2 5     B7 Family Member, H42
B7-H41 2     B7 Superfamily Member 12
Immune Costimulatory Protein B7-H42 3     T Cell Costimulatory Molecule B7x2
B7h.52 3     V-Set Domain-Containing T-Cell Activation Inhibitor 12
T-Cell Costimulatory Molecule B7x2 3     Protein B7S13

External Ids:    HGNC: 288731   Entrez Gene: 796792   Ensembl: ENSG000001342587   OMIM: 6081625   UniProtKB: Q7Z7D33   

Export aliases for VTCN1 gene to outside databases

Previous GC identifers: GC01M117399 GC01M115544


Summaries
for VTCN1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for VTCN1:
This gene encodes a protein belonging to the B7 costimulatory protein family. Proteins in this family are present on
the surface of antigen-presenting cells and interact with ligand bound to receptors on the surface of T cells. Studies
have shown that high levels of the encoded protein has been correlated with tumor progression. A pseudogene of this
gene is located on chromosome 20. Multiple transcript variants encoding different isoforms have been found for this
gene. (provided by RefSeq, Dec 2011)

UniProtKB/Swiss-Prot: VTCN1_HUMAN, Q7Z7D3
Function: Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine
production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an
important role, together with regulatory T-cells (Treg), in the suppression of tumor-associated antigen-specific
T-cell immunity. Involved in promoting epithelial cell transformation

Gene Wiki entry for VTCN1


Genomic Views
for VTCN1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_032977.9  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the VTCN1 gene promoter:
         LHX3b/Lhx3b   Tal-1   AP-1   E47   AREB6   POU2F1   POU2F1a   LHX3a/Lhx3a   Ik-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: VTCN1 promoter sequence
   Search SABiosciences Chromatin IP Primers for VTCN1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat VTCN1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p13.1   Ensembl cytogenetic band:  1p13.1   HGNC cytogenetic band: 1p12

VTCN1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
VTCN1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M117686:  view genomic region     (about GC identifiers)

Start:
 117,686,209 bp from pter      End:
 117,753,556 bp from pter
Size:
 67,348 bases      Orientation:
 minus strand

Proteins
for VTCN1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: VTCN1_HUMAN, Q7Z7D3 (See protein sequence)
Recommended Name: V-set domain-containing T-cell activation inhibitor 1 precursor  
Size: 282 amino acids; 30878 Da
Subcellular location: Cell membrane; Single-pass type I membrane protein (Potential). Note=Expressed at the cell
surface. A soluble form has also been detected
Miscellaneous: May serve as a predictive marker for renal cell carcinoma
Caution: The mouse ortholog has been shown (PubMed:12818166) to be a GPI-anchored protein but the Gly residue which is
predicted to be the modified site in mouse and rat is not conserved in human
1 PDB 3D structure from and Proteopedia for VTCN1:
4GOS (3D)    
Secondary accessions: Q0GN76 Q45VN0 Q5WPZ3 Q6P097 Q9H6B2
Alternative splicing: 4 isoforms:  Q7Z7D3-1   Q7Z7D3-2   Q7Z7D3-3   Q7Z7D3-4   

Explore the universe of human proteins at neXtProt for VTCN1: NX_Q7Z7D3

Post-translational modifications:

  • N-glycosylated1
  • View neXtProt modification sites for NX_Q7Z7D3

    • VTCN1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001240778.1  NP_001240779.1  NP_078902.2  

    ENSEMBL proteins: 
     ENSP00000358470   ENSP00000351899   ENSP00000328168   ENSP00000444724  

    Human Recombinant Protein Products: 
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    Novus Biologicals VTCN1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for VTCN1

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane ----
    GO:0009897external side of plasma membrane IEA--
    GO:0016021integral to membrane IEA--


    VTCN1 for ontologies           About GeneDecksing



    VTCN1 Antibody Products: 
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    Protein Domains /
    Families
    for VTCN1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    VTCN1 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR007110 Ig-like_dom
     IPR003599 Ig_sub
     IPR013783 Ig-like_fold
     IPR013106 Ig_V-set

    Graphical View of Domain Structure for InterPro Entry Q7Z7D3

    ProtoNet protein and cluster: Q7Z7D3

    1 Blocks protein family: IPB013106 Immunoglobulin V-set

    UniProtKB/Swiss-Prot: VTCN1_HUMAN, Q7Z7D3
    Similarity: Belongs to the immunoglobulin superfamily. BTN/MOG family
    Similarity: Contains 2 Ig-like V-type (immunoglobulin-like) domains


    Function
    for VTCN1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: VTCN1_HUMAN, Q7Z7D3
    Function: Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine
    production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an
    important role, together with regulatory T-cells (Treg), in the suppression of tumor-associated antigen-specific
    T-cell immunity. Involved in promoting epithelial cell transformation
    Induction: Up-regulated by IL6/interleukin-6 and IL10/interleukin-10 and inhibited by CSF2/GM-CSF and IL4/interleukin-4
    on antigen-presenting cells (APCs)

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat VTCN1
    8/18 QIAGEN miScript miRNA Assays for microRNAs that regulate VTCN1 (see all 18):
    hsa-miR-579 hsa-miR-125a-5p hsa-miR-449a hsa-miR-511 hsa-miR-149 hsa-miR-125b hsa-miR-508-5p hsa-miR-1827
    SwitchGear 3'UTR luciferase reporter plasmid: VTCN1 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for VTCN1 (see all 7)
    OriGene shRNA RFP: VTCN1
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat VTCN1

    Gene Editing
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    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for VTCN1 (see all 3)
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    Cell Line
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    Search LifeMap BioReagents cell lines for VTCN1

    In Situ Assay
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         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VTCN1

    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding IEA--


    VTCN1 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for VTCN1:
     Increased gamma-H2AX phosphory 

    Animal Models:
         Mouse knock-outs for VTCN1: Vtcn1tm1Lpc Vtcn1tm1Xxz Vtcn1tm1Mak
         6 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Vtcn1):
     cellular  hematopoietic system  homeostasis/metabolism  immune system  mortality/aging 
     normal 

    VTCN1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for VTCN1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for VTCN1

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for VTCN1 (Q7Z7D33 ENSP000003584704) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BTLAQ7Z6A93, ENSP000003339194I2D: score=1 STRING: ENSP00000333919
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001562response to protozoan IEA--
    GO:0050868negative regulation of T cell activation IEA--
    GO:0072602interleukin-4 secretion IEA--
    GO:0072643interferon-gamma secretion IEA--


    VTCN1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for VTCN1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for VTCN1
    Search CenterWatch for drugs/clinical trials and news about VTCN1 

    Transcripts
    for VTCN1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for VTCN1 gene (3 alternative transcripts): 
    NM_001253849.1  NM_001253850.1  NM_024626.3  

    Unigene Cluster for VTCN1:

    V-set domain containing T cell activation inhibitor 1
    Hs.546434  [show with all ESTs]
    Unigene Representative Sequence: NR_045603
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000369458(uc021oso.1 uc001ehb.3 uc001ehc.3 uc009whf.2)
    ENST00000359008(uc021osn.1) ENST00000463461 ENST00000488493 ENST00000328189
    ENST00000539893

    miRNA
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    hsa-miR-579 hsa-miR-125a-5p hsa-miR-449a hsa-miR-511 hsa-miR-149 hsa-miR-125b hsa-miR-508-5p hsa-miR-1827
    SwitchGear 3'UTR luciferase reporter plasmid: VTCN1 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for VTCN1 (see all 7)
    OriGene shRNA RFP: VTCN1
    OriGene siRNA: VTCN1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat VTCN1
    Clone
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat VTCN1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat VTCN1

    Additional cDNA sequence: 

    AK225413.1 AK303466.1 AK310812.1 AY280972.1 AY346100.1 AY358352.1 AY442303.1 BC065717.1 
    BC074729.2 BX648021.1 DQ103757.1 DQ836392.1 NR_045603.1 NR_045604.1 

    3 DOTS entries:

    DT.100697933  DT.92070437  DT.312331 

    24/70 AceView cDNA sequences (see all 70):

    AA404609 AI539195 CB852239 AI683712 CA311913 NM_024626 BM981657 AI686571 
    CR603772 AI682137 AK026071 AY280972 AW615203 AI859795 AA554431 AW073686 
    CA314865 CA426580 AY358352 BX648021 AI799522 AI539668 BM982674 AA333549 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for VTCN1    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c
    SP1:              -                                                         
    SP2:              -           -                                             
    SP3:                          -                                             
    SP4:              -           -     -                                       


    ECgene alternative splicing isoforms for VTCN1

    Expression
    for VTCN1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    VTCN1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTGTTATAGA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    VTCN1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 2 LifeMap Cells 
    NameCategory
    Syncytiotrophoblast-like cells (Generation of syncyt...)
    Human kidney epithelial cell spheroids (Kidney spheroids for...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See VTCN1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for VTCN1

    SOURCE GeneReport for Unigene cluster: Hs.546434

    UniProtKB/Swiss-Prot: VTCN1_HUMAN, Q7Z7D3
    Tissue specificity: Overexpressed in breast, ovarian, endometrial, renal cell (RCC) and non-small-cell lung cancers
    (NSCLC). Expressed on activated T- and B-cells, monocytes and dendritic cells, but not expressed in most normal
    tissues (at protein level). Widely expressed, including in kidney, liver, lung, ovary, placenta, spleen and testis

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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VTCN1

    Orthologs
    for VTCN1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for VTCN1 gene from 2/8 species (see all 8)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves VTCN11 V-set domain containing T cell activation inhibitor more 65.56(n)
    63.07(a)    		   418323  XM_416546.3  XP_416546.3 
    zebrafish
    (Danio rerio)    		 Actinopterygii LOC1005376761 v-set domain-containing T-cell activation inhibitor more 50.14(n)
    39.08(a)    		   100537676  XM_003199211.1  XP_003199259.1 


    ENSEMBL Gene Tree for VTCN1 (if available)
    TreeFam Gene Tree for VTCN1 (if available) 

    Paralogs
    for VTCN1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for VTCN1 gene
    BTN3A22  BTN2A12  BTNL82  ERMAP2  BTN3A32  BTN2A22  HHLA22  CD2762  
    BTNL102  MOG2  BTNL22  BTN3A12  BTN1A12  BTNL92  BTNL32  

    VTCN1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for VTCN1
    PGOHUM00000247615


    Genomic Variants
    for VTCN1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1240 NCBI SNPs in VTCN1 are shown (see all 1240)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1836017081,2
    		--117685807(+) ATTAAA/GGGACT 5 -- int10--------
    rs1450804331,2
    		--117685907(+) GCAATC/TAGTTT 5 -- int10--------
    rs66738371,2
    		C,F,H,--117685992(+) TGCCAG/AGCTGG 5 -- int133Minor allele frequency- A:0.10NS EA NA WA CSA 3091
    rs1894925461,2
    		--117686172(+) ATCTTC/GCCTTC 5 -- int10--------
    rs1818398821,2
    		--117686173(+) TCTTCC/GCTTCA 5 -- int10--------
    rs1386977771,2
    		--117686184(+) CTCACG/TTTTTT 5 -- int10--------
    rs557529291,2
    		C--117686271(+) TTTTCC/TATAAC 5 -- ut31 nc-transcript-variant0--------
    rs135051,2
    		C,F,A,H,--117686492(-) ACCCTT/GCCTGG 5 -- ut31 nc-transcript-variantese326Minor allele frequency- G:0.20MN NS EA NA WA CSA 2719
    rs64286791,2
    		C,F,A,H,--117686827(+) CTTAGT/CCCTGA 5 -- nc-transcript-variantut31 ese313Minor allele frequency- C:0.19NA WA CSA EA 377
    rs1152992921,2
    		C,F,--117686838(+) CACAGT/CTGACA 5 -- nc-transcript-variantut311Minor allele frequency- C:0.02WA 118

    HapMap Linkage Disequilibrium report for VTCN1 (117686209 - 117753556 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for VTCN1: --

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    Disorders / Diseases
    for VTCN1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    VTCN1 for disorders           About GeneDecksing

    OMIM gene information: 608162    OMIM disorders: --

    19 diseases for VTCN1:    About MalaCards
    esophageal squamous cell carcinoma    squamous cell carcinoma    sporadic breast cancer    breast-ovarian cancer
    renal cell carcinoma    ovarian cancer    breast cancer    ovarian carcinoma
    esophagitis    gastric cancer    carcinoma    pancreatic cancer
    lung cancer    prostate cancer    pancreatitis    prostatitis
    arthritis    melanoma    adenocarcinoma

    Human Genome Epidemiology (HuGE) Navigator: VTCN1 (3 documents)

    Export disorders for VTCN1 gene to outside databases

    Publications
    for VTCN1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for VTCN1 gene, integrated from 9 sources (see all 45):
    (articles sorted by number of sources associating them with VTCN1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. B7-H4, a molecule of the B7 family, negatively regulates T cell immunity. (PubMed id 12818165)1, 2, 3 Sica G.L.... Chen L. (2003)
    2. B7-H4 (DD-O110) is overexpressed in high risk uterine endometrioid adenocarcinomas and inversely correlated with tumor T-cell infiltration. (PubMed id 17509674)1, 2 Miyatake T.... Shroyer K.R. (2007)
    3. B7-H3 and B7-H4 expression in non-small-cell lung cancer. (PubMed id 16782226)1, 2 Sun Y.... Wang X. (2006)
    4. Cutting edge: induction of B7-H4 on APCs through IL-10: novel suppressive mode for regulatory T cells. (PubMed id 16785496)1, 2 Kryczek I....Zou W. (2006)
    5. B7-H4 expression in renal cell carcinoma and tumor vasculature: associations with cancer progression and survival. (PubMed id 16798883)1, 2 Krambeck A.E.... Kwon E.D. (2006)
    6. B7-H4 expression identifies a novel suppressive macrophage population in human ovarian carcinoma. (PubMed id 16606666)1, 2 Kryczek I....Zou W. (2006)
    7. The immunomodulatory protein B7-H4 is overexpressed in breast and ovarian cancers and promotes epithelial cell transformation. (PubMed id 15878339)1, 2 Salceda S.... Papkoff J. (2005)
    8. B7S1, a novel B7 family member that negatively regulates T cell activation. (PubMed id 12818166)1, 3 Prasad D.V....Dong C. (2003)
    9. Genomic organization and expression analysis of B7-H4, an immune inhibitory molecule of the B7 family. (PubMed id 14568939)1, 2 Choi I.H....Chen L. (2003)
    10. B7x: a widely expressed B7 family member that inhibits T cell activation. (PubMed id 12920180)1, 2 Zang X.... Allison J.P. (2003)

    External Searches for VTCN1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing VTCN1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 79679 HGNC: 28873 AceView: B7-H4 Ensembl:ENSG00000134258 euGenes: HUgn79679
    ECgene: VTCN1 H-InvDB: VTCN1

    Other Databases showing VTCN1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing VTCN1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for VTCN1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for VTCN1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for VTCN1 gene:
    Search GeneIP for patents involving VTCN1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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