Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



VTCN1 Gene

protein-coding   GIFtS: 55
GCID: GC01M117686

V-Set Domain Containing T Cell Activation Inhibitor 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
V-Set Domain Containing T Cell Activation Inhibitor 11 2     H41
B7H42 3 5     B7 Family Member1
B7 Superfamily Member 11 2     B7-H42
Immune Costimulatory Protein B7-H42 3     PRO12912
B7h.52 3     B7 Family Member, H42
T-Cell Costimulatory Molecule B7x2 3     T Cell Costimulatory Molecule B7x2
B7S12 5     V-Set Domain-Containing T-Cell Activation Inhibitor 12
B7X2 5     Protein B7S13
VCTN12 5     

External Ids:    HGNC: 288731   Entrez Gene: 796792   Ensembl: ENSG000001342587   OMIM: 6081625   UniProtKB: Q7Z7D33   

Export aliases for VTCN1 gene to outside databases

Previous GC identifers: GC01M117399 GC01M115544


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for VTCN1 Gene:
This gene encodes a protein belonging to the B7 costimulatory protein family. Proteins in this family are present
on the surface of antigen-presenting cells and interact with ligand bound to receptors on the surface of T cells.
Studies have shown that high levels of the encoded protein has been correlated with tumor progression. A
pseudogene of this gene is located on chromosome 20. Multiple transcript variants encoding different isoforms
have been found for this gene. (provided by RefSeq, Dec 2011)

GeneCards Summary for VTCN1 Gene:
VTCN1 (V-set domain containing T cell activation inhibitor 1) is a protein-coding gene. Diseases associated with VTCN1 include sporadic breast cancer, and primary biliary cirrhosis. GO annotations related to this gene include receptor binding. An important paralog of this gene is HHLA2.

UniProtKB/Swiss-Prot: VTCN1_HUMAN, Q7Z7D3
Function: Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation,
cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages,
plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor-associated
antigen-specific T-cell immunity. Involved in promoting epithelial cell transformation

Gene Wiki entry for VTCN1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000001.11  NC_018912.2  NT_032977.10  
Regulatory elements:
   Regulatory transcription factor binding sites in the VTCN1 gene promoter:
         LHX3b/Lhx3b   Tal-1   AP-1   E47   AREB6   POU2F1   POU2F1a   LHX3a/Lhx3a   Ik-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidVTCN1 promoter sequence
   Search Chromatin IP Primers for VTCN1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat VTCN1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p13.1   Ensembl cytogenetic band:  1p13.1   HGNC cytogenetic band: 1p12

VTCN1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
VTCN1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M117686:  view genomic region     (about GC identifiers)

Start:
117,686,209 bp from pter      End:
117,753,556 bp from pter
Size:
67,348 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: VTCN1_HUMAN, Q7Z7D3 (See protein sequence)
Recommended Name: V-set domain-containing T-cell activation inhibitor 1 precursor  
Size: 282 amino acids; 30878 Da
Miscellaneous: May serve as a predictive marker for renal cell carcinoma
Caution: The mouse ortholog has been shown (PubMed:12818166) to be a GPI-anchored protein but the Gly residue
which is predicted to be the modified site in mouse and rat is not conserved in human
1 PDB 3D structure from and Proteopedia for VTCN1:
4GOS (3D)    
Secondary accessions: Q0GN76 Q45VN0 Q5WPZ3 Q6P097 Q9H6B2
Alternative splicing: 4 isoforms:  Q7Z7D3-1   Q7Z7D3-2   Q7Z7D3-3   Q7Z7D3-4   

Explore the universe of human proteins at neXtProt for VTCN1: NX_Q7Z7D3

Explore proteomics data for VTCN1 at MOPED

Post-translational modifications: 

  • N-glycosylated1
  • Glycosylation2 at Asn216

  • See VTCN1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001240778.1  NP_001240779.1  NP_078902.2  

    ENSEMBL proteins: 
     ENSP00000351899   ENSP00000358470   ENSP00000328168   ENSP00000444724  

    VTCN1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for VTCN1 (B7-H4)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for VTCN1
    OriGene Custom MassSpec
    OriGene Custom Protein Services for VTCN1
    GenScript Custom Purified and Recombinant Proteins Services for VTCN1
    Novus Biologicals VTCN1 Protein
    Novus Biologicals VTCN1 Lysate
    Sino Biological Recombinant Protein for VTCN1
    Sino Biological Cell Lysate for VTCN1
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for VTCN1

    VTCN1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for VTCN1 (B7-H4)
    OriGene Antibodies for VTCN1
    OriGene Custom Antibody Services for VTCN1
    Novus Biologicals VTCN1 Antibodies
    Abcam antibodies for VTCN1
    Cloud-Clone Corp. Antibodies for VTCN1
    ThermoFisher Antibodies for VTCN1
    LSBio Antibodies in human, mouse, rat for VTCN1

    VTCN1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for VTCN1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for VTCN1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for VTCN1
    Cloud-Clone Corp. CLIAs for VTCN1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing
    VSET: Immunoglobulin superfamily / V-set domain containing

    4 InterPro protein domains:
     IPR013783 Ig-like_fold
     IPR013106 Ig_V-set
     IPR007110 Ig-like_dom
     IPR003599 Ig_sub

    Graphical View of Domain Structure for InterPro Entry Q7Z7D3

    ProtoNet protein and cluster: Q7Z7D3

    1 Blocks protein domain: IPB013106 Immunoglobulin V-set

    UniProtKB/Swiss-Prot: VTCN1_HUMAN, Q7Z7D3
    Similarity: Belongs to the immunoglobulin superfamily. BTN/MOG family
    Similarity: Contains 2 Ig-like V-type (immunoglobulin-like) domains


    VTCN1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: VTCN1_HUMAN, Q7Z7D3
    Function: Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation,
    cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages,
    plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor-associated
    antigen-specific T-cell immunity. Involved in promoting epithelial cell transformation
    Induction: Up-regulated by IL6/interleukin-6 and IL10/interleukin-10 and inhibited by CSF2/GM-CSF and
    IL4/interleukin-4 on antigen-presenting cells (APCs)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding IEA--
    GO:0005515protein binding ----
         
    VTCN1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for VTCN1:
     Increased gamma-H2AX phosphory 

         6 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Vtcn1):
     cellular  hematopoietic system  homeostasis/metabolism  immune system  mortality/aging 
     normal 

    VTCN1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for VTCN1: Vtcn1tm1Lpc Vtcn1tm1Xxz Vtcn1tm1Mak

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for VTCN1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for VTCN1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for VTCN1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for VTCN1

    miRNA
    Products:
        
    miRTarBase miRNAs that target VTCN1:
    hsa-mir-335-5p (MIRT018842)

    Block miRNA regulation of human, mouse, rat VTCN1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate VTCN1 (see all 18):
    hsa-miR-579 hsa-miR-125a-5p hsa-miR-449a hsa-miR-511 hsa-miR-149 hsa-miR-125b hsa-miR-508-5p hsa-miR-1827
    SwitchGear 3'UTR luciferase reporter plasmidVTCN1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for VTCN1
    Predesigned siRNA for gene silencing in human, mouse, rat VTCN1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for VTCN1

    Clone
    Products:
         
    OriGene clones in human, mouse for VTCN1 (see all 6)
    OriGene ORF clones in mouse, rat for VTCN1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: VTCN1 (NM_024626)
    Sino Biological Human cDNA Clone for VTCN1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for VTCN1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VTCN1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for VTCN1
    Browse ESI BIO Cell Lines and PureStem Progenitors for VTCN1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VTCN1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    VTCN1_HUMAN, Q7Z7D3: Cell membrane; Single-pass type I membrane protein (Potential). Note=Expressed at the cell
    surface. A soluble form has also been detected
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0009897external side of plasma membrane IEA--
    GO:0016021integral component of membrane IEA--

    VTCN1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for VTCN1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Cell adhesion molecules (CAMs)
    Cell adhesion molecules (CAMs)

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways




    1 Kegg Pathway  (Kegg details for VTCN1):
        Cell adhesion molecules (CAMs)


    VTCN1 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for VTCN1
    Interactions:

        Search GeneGlobe Interaction Network for VTCN1

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for VTCN1 (Q7Z7D33 ENSP000003584704) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BTLAQ7Z6A93, ENSP000003339194I2D: score=1 STRING: ENSP00000333919
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001562response to protozoan IEA--
    GO:0002376immune system process IEA--
    GO:0050868negative regulation of T cell activation IEA--
    GO:0072602interleukin-4 secretion IEA--
    GO:0072643interferon-gamma secretion IEA--

    VTCN1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for VTCN1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for VTCN1 gene (3 alternative transcripts): 
    NM_001253849.1  NM_001253850.1  NM_024626.3  

    Unigene Cluster for VTCN1:

    V-set domain containing T cell activation inhibitor 1
    Hs.546434  [show with all ESTs]
    Unigene Representative Sequence: NR_045603
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000359008(uc021osn.1) ENST00000369458(uc021oso.1 uc001ehb.3 uc001ehc.3 uc009whf.2)
    ENST00000463461 ENST00000488493 ENST00000328189 ENST00000539893
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat VTCN1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate VTCN1 (see all 18):
    hsa-miR-579 hsa-miR-125a-5p hsa-miR-449a hsa-miR-511 hsa-miR-149 hsa-miR-125b hsa-miR-508-5p hsa-miR-1827
    SwitchGear 3'UTR luciferase reporter plasmidVTCN1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for VTCN1
    Predesigned siRNA for gene silencing in human, mouse, rat VTCN1
    Clone
    Products:
         
    OriGene clones in human, mouse for VTCN1 (see all 6)
    OriGene ORF clones in mouse, rat for VTCN1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: VTCN1 (NM_024626)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for VTCN1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VTCN1
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for VTCN1
    OriGene qSTAR qPCR primer pairs in human, mouse for VTCN1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat VTCN1
      QuantiTect SYBR Green Assays in human, mouse, rat VTCN1
      QuantiFast Probe-based Assays in human, mouse, rat VTCN1

    Additional mRNA sequence: 

    AK225413.1 AK303466.1 AK310812.1 AY280972.1 AY346100.1 AY358352.1 AY442303.1 BC065717.1 
    BC074729.2 BX648021.1 DQ103757.1 DQ836392.1 NR_045603.1 NR_045604.1 

    3 DOTS entries:

    DT.100697933  DT.92070437  DT.312331 

    Selected AceView cDNA sequences (see all 70):

    BM981657 AI683712 AI686571 AI682137 CA311913 AK026071 AI539195 CB852239 
    NM_024626 AY280972 CR603772 AA404609 CA426580 AY358352 CB241729 BU680630 
    BE741325 AI799522 BX369964 AI870700 AI370413 AW615203 AW073686 AW150534 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for VTCN1    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c
    SP1:              -                                                         
    SP2:              -           -                                             
    SP3:                          -                                             
    SP4:              -           -     -                                       


    ECgene alternative splicing isoforms for VTCN1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    VTCN1 expression in normal human tissues (normalized intensities)      VTCN1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTGTTATAGA
    VTCN1 Expression
    About this image


    VTCN1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Liver (Hepatobiliary System)    fully expand to see all 2 entries
             Mature Mesothelial Cells Hepatic Mesenchyme
             Hepatocyte-like cells
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
             Human embryonic stem cells (family)
     
     Epithelial Cells
             Podocytes Podocyte Layer
     
     Kidney (Urinary System)
             Podocytes Podocyte Layer
    VTCN1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    VTCN1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.546434

    UniProtKB/Swiss-Prot: VTCN1_HUMAN, Q7Z7D3
    Tissue specificity: Overexpressed in breast, ovarian, endometrial, renal cell (RCC) and non-small-cell lung
    cancers (NSCLC). Expressed on activated T- and B-cells, monocytes and dendritic cells, but not expressed in most
    normal tissues (at protein level). Widely expressed, including in kidney, liver, lung, ovary, placenta, spleen
    and testis

        Custom PCR Arrays for VTCN1
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for VTCN1
    OriGene qSTAR qPCR primer pairs in human, mouse for VTCN1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat VTCN1
    QuantiTect SYBR Green Assays in human, mouse, rat VTCN1
    QuantiFast Probe-based Assays in human, mouse, rat VTCN1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VTCN1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for VTCN1 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Vtcn11 , 5 V-set domain containing T cell activation inhibitor more1, 5 84.52(n)1
    87.94(a)1
      3 (43.78 cM)5
    2421221  NM_178594.31  NP_848709.21 
     1008254595 
    chicken
    (Gallus gallus)
    Aves VTCN11 V-set domain containing T cell activation inhibitor more 63.37(n)
    59.34(a)
      418323  XM_416546.4  XP_416546.4 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia vtcn11 V-set domain containing T cell activation inhibitor more 53.79(n)
    42.05(a)
      493551  NM_001008188.1  NP_001008189.1 
    zebrafish
    (Danio rerio)
    Actinopterygii si:dkey-174k18.61 si:dkey-174k18.6 50.07(n)
    38.91(a)
      100537676  XM_003199211.2  XP_003199259.1 


    ENSEMBL Gene Tree for VTCN1 (if available)
    TreeFam Gene Tree for VTCN1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for VTCN1 gene
    HHLA22  CD2762  

    VTCN1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for VTCN1
    PGOHUM00000247615


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for VTCN1 (see all 1432)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1836017081,2
    --117685807(+) ATTAAA/GGGACT 5 -- int10--------
    rs1450804331,2
    C--117685907(+) GCAATC/TAGTTT 5 -- int10--------
    rs66738371,2
    C,F,H--117685992(+) TGCCAG/AGCTGG 5 -- int133Minor allele frequency- A:0.10NS EA NA WA CSA 3091
    rs1894925461,2
    --117686172(+) ATCTTC/GCCTTC 5 -- int10--------
    rs1818398821,2
    --117686173(+) TCTTCC/GCTTCA 5 -- int10--------
    rs1386977771,2
    --117686184(+) CTCACG/TTTTTT 5 -- int10--------
    rs557529291,2
    C--117686271(+) TTTTCC/TATAAC 5 -- ut31 nc-transcript-variant0--------
    rs135051,2
    C,F,A,H--117686492(-) ACCCTT/GCCTGG 5 -- ut31 nc-transcript-variantese326Minor allele frequency- G:0.20MN NS EA NA WA CSA 2719
    rs64286791,2
    C,F,A,H--117686827(+) CTTAGT/CCCTGA 5 -- ut31 nc-transcript-variantese313Minor allele frequency- C:0.19NA WA CSA EA 377
    rs1152992921,2
    C,F--117686838(+) CACAGT/CTGACA 5 -- ut31 nc-transcript-variant1Minor allele frequency- C:0.02WA 118

    HapMap Linkage Disequilibrium report for VTCN1 (117686209 - 117753556 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for VTCN1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2716640CNV Deletion23290073

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing VTCN1
    DNA2.0 Custom Variant and Variant Library Synthesis for VTCN1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 608162    OMIM disorders: --

    20 diseases for VTCN1:    About MalaCards
    sporadic breast cancer    primary biliary cirrhosis    esophageal squamous cell carcinoma    renal cell carcinoma
    cervical cancer    ovarian cancer    cervicitis    esophagitis
    squamous cell carcinoma    pancreatic cancer    lung cancer    breast cancer
    pancreatitis    rheumatoid arthritis    arthritis    melanoma
    adenocarcinoma    prostate cancer    prostatitis    hepatitis


    VTCN1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): VTCN1
    Human Genome Epidemiology (HuGE) Navigator: VTCN1 (3 documents)

    Export disorders for VTCN1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for VTCN1 gene, integrated from 10 sources (see all 53):
    (articles sorted by number of sources associating them with VTCN1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. B7-H4, a molecule of the B7 family, negatively regulates T cell immunity. (PubMed id 12818165)1, 2, 3 Sica G.L.... Chen L. (Immunity 2003)
    2. B7-H4 gene polymorphisms are associated with sporadic breast cancer in a Chinese Han population. (PubMed id 19903360)1, 4 Zhang J....Li D. (BMC Cancer 2009)
    3. Identification of a novel susceptibility locus for juvenile idiopathic arthritis by genome-wide association analysis. (PubMed id 19116933)1, 4 Hinks A....Thomson W. (Arthritis Rheum. 2009)
    4. B7-H4 (DD-O110) is overexpressed in high risk uterine endometrioid adenocarcinomas and inversely correlated with tumor T-cell infiltration. (PubMed id 17509674)1, 2 Miyatake T.... Shroyer K.R. (Gynecol. Oncol. 2007)
    5. B7-H3 and B7-H4 expression in non-small-cell lung cancer. (PubMed id 16782226)1, 2 Sun Y.... Wang X. (Lung Cancer 2006)
    6. Induction of B7-H4 on APCs through IL-10: novel suppressive mode for regulatory T cells. (PubMed id 16785496)1, 2 Kryczek I....Zou W. (J. Immunol. 2006)
    7. B7-H4 expression in renal cell carcinoma and tumor vasculature: associations with cancer progression and survival. (PubMed id 16798883)1, 2 Krambeck A.E.... Kwon E.D. (Proc. Natl. Acad. Sci. U.S.A. 2006)
    8. B7-H4 expression identifies a novel suppressive macrophage population in human ovarian carcinoma. (PubMed id 16606666)1, 2 Kryczek I.... Zou W. (J. Exp. Med. 2006)
    9. The immunomodulatory protein B7-H4 is overexpressed in breast and ovarian cancers and promotes epithelial cell transformation. (PubMed id 15878339)1, 2 Salceda S.... Papkoff J. (Exp. Cell Res. 2005)
    10. B7S1, a novel B7 family member that negatively regulates T cell activation. (PubMed id 12818166)1, 3 Prasad D.V....Dong C. (Immunity 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 79679 HGNC: 28873 AceView: B7-H4 Ensembl:ENSG00000134258 euGenes: HUgn79679
    ECgene: VTCN1 Kegg: 79679 H-InvDB: VTCN1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for VTCN1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for VTCN1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for VTCN1 gene:
    Search GeneIP for patents involving VTCN1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Antibodies for VTCN1 (B7-H4)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Recombinant/Natural Proteins for VTCN1 (B7-H4)   Browse Stem Cell Products  
     cDNA Clones for VTCN1 (B7-H4)   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for VTCN1   OriGene RNAi products in human, mouse, rat for VTCN1  
     OriGene qPCR primer pairs and template standards for VTCN1   OriGene Protein Over-expression Lysate for VTCN1  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for VTCN1  
     OriGene qSTAR qPCR primer pairs in human, mouse for VTCN1   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for VTCN1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for VTCN1   OriGene Custom Protein Services for VTCN1  

     
     
     Block miRNA regulation of human, mouse, rat VTCN1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing VTCN1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat VTCN1 Predesigned siRNA for gene silencing in human, mouse, rat VTCN1
     QuantiFast Probe-based Assays in human, mouse, rat VTCN1 QuantiTect SYBR Green Assays in human, mouse, rat VTCN1
     Custom PCR Arrays for VTCN1 Search Chromatin IP Primers for VTCN1
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat VTCN1  Search GeneGlobe Interaction Network for VTCN1
     Regulatory tfbs in VTCN1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for VTCN1 GenScript cDNA clones with any tag delivered in your preferred vector for VTCN1
     GenScript Custom Assay Services for VTCN1 GenScript Custom overexpressing Cell Line Services for VTCN1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for VTCN1
     Proteins for VTCN1
     Cell Lysates for VTCN1
     cDNA Clones for VTCN1
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     VTCN1 antibodies
     VTCN1 proteins
     VTCN1 lysates
     Antibodies for VTCN1
     See all of Abcam's Antibodies, Kits and Proteins for VTCN1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for VTCN1
     Antibodies for VTCN1
     ELISAs for VTCN1
     CLIAs for VTCN1



     Browse ESI BIO Cell Lines and PureStem Progenitors for VTCN1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VTCN1
     SwitchGear 3'UTR luciferase reporter plasmids for VTCN1
     SwitchGear Promoter luciferase reporter plasmids for VTCN1
     ThermoFisher Antibodies for VTCN1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VTCN1
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for VTCN1
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for VTCN1
     LSBio Antibodies in human, mouse, rat for VTCN1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      VTCN1 gene at Home site.
    Version: 3.12.136 22 July 2014
    hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4