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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

VTCN1 Gene

protein-coding   GIFtS: 54
GCID: GC01M117686

V-Set Domain Containing T Cell Activation Inhibitor 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
V-Set Domain Containing T Cell Activation Inhibitor 11 2     H41
B7H42 3 5     B7 Family Member1
B7 Superfamily Member 11 2     B7-H42
Immune Costimulatory Protein B7-H42 3     PRO12912
B7h.52 3     B7 Family Member, H42
T-Cell Costimulatory Molecule B7x2 3     T Cell Costimulatory Molecule B7x2
B7S12 5     V-Set Domain-Containing T-Cell Activation Inhibitor 12
B7X2 5     Protein B7S13
VCTN12 5     

External Ids:    HGNC: 288731   Entrez Gene: 796792   Ensembl: ENSG000001342587   OMIM: 6081625   UniProtKB: Q7Z7D33   

Export aliases for VTCN1 gene to outside databases

Previous GC identifers: GC01M117399 GC01M115544


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for VTCN1 Gene:
This gene encodes a protein belonging to the B7 costimulatory protein family. Proteins in this family are present
on the surface of antigen-presenting cells and interact with ligand bound to receptors on the surface of T cells.
Studies have shown that high levels of the encoded protein has been correlated with tumor progression. A
pseudogene of this gene is located on chromosome 20. Multiple transcript variants encoding different isoforms
have been found for this gene. (provided by RefSeq, Dec 2011)

GeneCards Summary for VTCN1 Gene: 
VTCN1 (V-set domain containing T cell activation inhibitor 1) is a protein-coding gene. Diseases associated with VTCN1 include sporadic breast cancer, and esophageal squamous cell carcinoma. GO annotations related to this gene include receptor binding. An important paralog of this gene is ICOSLG.

UniProtKB/Swiss-Prot: VTCN1_HUMAN, Q7Z7D3
Function: Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation,
cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages,
plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor-associated
antigen-specific T-cell immunity. Involved in promoting epithelial cell transformation

Gene Wiki entry for VTCN1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_032977.9  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the VTCN1 gene promoter:
         LHX3b/Lhx3b   Tal-1   AP-1   E47   AREB6   POU2F1   POU2F1a   LHX3a/Lhx3a   Ik-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidVTCN1 promoter sequence
   Search SABiosciences Chromatin IP Primers for VTCN1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat VTCN1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p13.1   Ensembl cytogenetic band:  1p13.1   HGNC cytogenetic band: 1p12

VTCN1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
VTCN1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M117686:  view genomic region     (about GC identifiers)

Start:
117,686,209 bp from pter      End:
117,753,556 bp from pter
Size:
67,348 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: VTCN1_HUMAN, Q7Z7D3 (See protein sequence)
Recommended Name: V-set domain-containing T-cell activation inhibitor 1 precursor  
Size: 282 amino acids; 30878 Da
Subcellular location: Cell membrane; Single-pass type I membrane protein (Potential). Note=Expressed at the cell
surface. A soluble form has also been detected
Miscellaneous: May serve as a predictive marker for renal cell carcinoma
Caution: The mouse ortholog has been shown (PubMed:12818166) to be a GPI-anchored protein but the Gly residue
which is predicted to be the modified site in mouse and rat is not conserved in human
1 PDB 3D structure from and Proteopedia for VTCN1:
4GOS (3D)    
Secondary accessions: Q0GN76 Q45VN0 Q5WPZ3 Q6P097 Q9H6B2
Alternative splicing: 4 isoforms:  Q7Z7D3-1   Q7Z7D3-2   Q7Z7D3-3   Q7Z7D3-4   

Explore the universe of human proteins at neXtProt for VTCN1: NX_Q7Z7D3

Explore proteomics data for VTCN1 at MOPED 

Post-translational modifications:

  • UniProtKB: N-glycosylated
  • View neXtProt modification sites for NX_Q7Z7D3

  • VTCN1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    VTCN1 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001240778.1  NP_001240779.1  NP_078902.2  

    ENSEMBL proteins: 
     ENSP00000351899   ENSP00000358470   ENSP00000328168   ENSP00000444724  

    Human Recombinant Protein Products for VTCN1: 
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    Sino Biological Cell Lysate for VTCN1 
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    Cloud-Clone Corp. Proteins for VTCN1 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0009897external side of plasma membrane IEA--
    GO:0016021integral to membrane IEA--

    VTCN1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing
    VSET: Immunoglobulin superfamily / V-set domain containing

    4 InterPro protein domains:
     IPR007110 Ig-like_dom
     IPR003599 Ig_sub
     IPR013783 Ig-like_fold
     IPR013106 Ig_V-set

    Graphical View of Domain Structure for InterPro Entry Q7Z7D3

    ProtoNet protein and cluster: Q7Z7D3

    1 Blocks protein domain: IPB013106 Immunoglobulin V-set

    UniProtKB/Swiss-Prot: VTCN1_HUMAN, Q7Z7D3
    Similarity: Belongs to the immunoglobulin superfamily. BTN/MOG family
    Similarity: Contains 2 Ig-like V-type (immunoglobulin-like) domains


    VTCN1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: VTCN1_HUMAN, Q7Z7D3
    Function: Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation,
    cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages,
    plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor-associated
    antigen-specific T-cell immunity. Involved in promoting epithelial cell transformation
    Induction: Up-regulated by IL6/interleukin-6 and IL10/interleukin-10 and inhibited by CSF2/GM-CSF and
    IL4/interleukin-4 on antigen-presenting cells (APCs)

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding IEA--
    GO:0005515protein binding ----
         
    VTCN1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for VTCN1:
     Increased gamma-H2AX phosphory 

         6 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Vtcn1):
     cellular  hematopoietic system  homeostasis/metabolism  immune system  mortality/aging 
     normal 

    VTCN1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for VTCN1: Vtcn1tm1Lpc Vtcn1tm1Xxz Vtcn1tm1Mak

       inGenious Targeting Laboratory - Custom generated mouse model solutions for VTCN1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for VTCN1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for VTCN1 
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    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidVTCN1 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VTCN1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for VTCN1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Cell adhesion molecules (CAMs)
    Cell adhesion molecules (CAMs)

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways




    1         Kegg Pathway  (Kegg details for VTCN1):
        Cell adhesion molecules (CAMs)


    VTCN1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for VTCN1

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for VTCN1 (Q7Z7D33 ENSP000003584704) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BTLAQ7Z6A93, ENSP000003339194I2D: score=1 STRING: ENSP00000333919
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001562response to protozoan IEA--
    GO:0050868negative regulation of T cell activation IEA--
    GO:0072602interleukin-4 secretion IEA--
    GO:0072643interferon-gamma secretion IEA--

    VTCN1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for VTCN1

    Search CenterWatch for drugs/clinical trials and news about VTCN1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for VTCN1 gene (3 alternative transcripts): 
    NM_001253849.1  NM_001253850.1  NM_024626.3  

    Unigene Cluster for VTCN1:

    V-set domain containing T cell activation inhibitor 1
    Hs.546434  [show with all ESTs]
    Unigene Representative Sequence: NR_045603
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000359008(uc021osn.1) ENST00000369458(uc021oso.1 uc001ehb.3 uc001ehc.3 uc009whf.2)
    ENST00000463461 ENST00000488493 ENST00000328189 ENST00000539893
    miRNA
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    hsa-miR-579 hsa-miR-125a-5p hsa-miR-449a hsa-miR-511 hsa-miR-149 hsa-miR-125b hsa-miR-508-5p hsa-miR-1827
    SwitchGear 3'UTR luciferase reporter plasmidVTCN1 3' UTR sequence
    Inhib. RNA
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat VTCN1
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    Additional mRNA sequence: 

    AK225413.1 AK303466.1 AK310812.1 AY280972.1 AY346100.1 AY358352.1 AY442303.1 BC065717.1 
    BC074729.2 BX648021.1 DQ103757.1 DQ836392.1 NR_045603.1 NR_045604.1 

    3 DOTS entries:

    DT.100697933  DT.92070437  DT.312331 

    24/70 AceView cDNA sequences (see all 70):

    AI539195 AK026071 AI682137 CR603772 AA404609 NM_024626 AI683712 AI686571 
    CB852239 AY280972 CA311913 BM981657 AY358352 BI963964 AI539668 BC065717 
    AY346100 BU680630 AA075579 BM982674 AI859795 BX369964 AI370413 CK903676 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for VTCN1    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c
    SP1:              -                                                         
    SP2:              -           -                                             
    SP3:                          -                                             
    SP4:              -           -     -                                       


    ECgene alternative splicing isoforms for VTCN1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    VTCN1 expression in normal human tissues (normalized intensities)      VTCN1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTGTTATAGA
    VTCN1 Expression
    About this image


    VTCN1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/11 selected tissues (see all 11) fully expand
     
     Epithelium (Uncategorized)    fully expand to see all 2 entries
             Human Tracheal Epithelial Cells (HTEpiC)   
             breast epithelium   
     
     Hair
             hair follicle bulge   
     
     Dermis (Integumentary System)    fully expand to see all 2 entries
             hair follicle bulge   
     
     Kidney (Urinary System)
             Podocytes Podocyte Layer
     
     Oral Cavity (Gastrointestinal Tract)
             mouth   

    See VTCN1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for VTCN1

    SOURCE GeneReport for Unigene cluster: Hs.546434

    UniProtKB/Swiss-Prot: VTCN1_HUMAN, Q7Z7D3
    Tissue specificity: Overexpressed in breast, ovarian, endometrial, renal cell (RCC) and non-small-cell lung
    cancers (NSCLC). Expressed on activated T- and B-cells, monocytes and dendritic cells, but not expressed in most
    normal tissues (at protein level). Widely expressed, including in kidney, liver, lung, ovary, placenta, spleen
    and testis

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VTCN1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for VTCN1 gene from 3/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Vtcn11 , 5 V-set domain containing T cell activation inhibitor more1, 5 84.52(n)1
    87.94(a)1
      3 (43.78 cM)5
    2421221  NM_178594.31  NP_848709.21 
     1008254595 
    chicken
    (Gallus gallus)
    Aves VTCN11 V-set domain containing T cell activation inhibitor more 65.56(n)
    63.07(a)
      418323  XM_416546.3  XP_416546.3 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1005376761 v-set domain-containing T-cell activation inhibitor more 50.14(n)
    39.08(a)
      100537676  XM_003199211.1  XP_003199259.1 


    ENSEMBL Gene Tree for VTCN1 (if available)
    TreeFam Gene Tree for VTCN1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for VTCN1 gene
    ICOSLG2  HHLA22  CD2762  

    VTCN1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for VTCN1
    PGOHUM00000247615


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1432 SNPs in VTCN1 are shown (see all 1432)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1836017081,2
    --117685807(+) ATTAAA/GGGACT 5 -- int10--------
    rs1450804331,2
    C--117685907(+) GCAATC/TAGTTT 5 -- int10--------
    rs66738371,2
    C,F,H--117685992(+) TGCCAG/AGCTGG 5 -- int133Minor allele frequency- A:0.10NS EA NA WA CSA 3091
    rs1894925461,2
    --117686172(+) ATCTTC/GCCTTC 5 -- int10--------
    rs1818398821,2
    --117686173(+) TCTTCC/GCTTCA 5 -- int10--------
    rs1386977771,2
    --117686184(+) CTCACG/TTTTTT 5 -- int10--------
    rs557529291,2
    C--117686271(+) TTTTCC/TATAAC 5 -- ut31 nc-transcript-variant0--------
    rs135051,2
    C,F,A,H--117686492(-) ACCCTT/GCCTGG 5 -- ut31 nc-transcript-variantese326Minor allele frequency- G:0.20MN NS EA NA WA CSA 2719
    rs64286791,2
    C,F,A,H--117686827(+) CTTAGT/CCCTGA 5 -- ut31 nc-transcript-variantese313Minor allele frequency- C:0.19NA WA CSA EA 377
    rs1152992921,2
    C,F--117686838(+) CACAGT/CTGACA 5 -- ut31 nc-transcript-variant1Minor allele frequency- C:0.02WA 118

    HapMap Linkage Disequilibrium report for VTCN1 (117686209 - 117753556 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for VTCN1:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2716640CNV Deletion23290073

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 608162    OMIM disorders: --

    19 diseases for VTCN1:    About MalaCards
    sporadic breast cancer    esophageal squamous cell carcinoma    primary biliary cirrhosis    renal cell carcinoma
    ovarian cancer    esophagitis    gastric cancer    squamous cell carcinoma
    cervical cancer    pancreatic cancer    lung cancer    pancreatitis
    breast cancer    cervicitis    arthritis    melanoma
    adenocarcinoma    prostate cancer    prostatitis


    VTCN1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): VTCN1
    Human Genome Epidemiology (HuGE) Navigator: VTCN1 (3 documents)

    Export disorders for VTCN1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for VTCN1 gene, integrated from 9 sources (see all 49):
    (articles sorted by number of sources associating them with VTCN1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. B7-H4, a molecule of the B7 family, negatively regulates T cell immunity. (PubMed id 12818165)1, 2, 3 Sica G.L.... Chen L. (2003)
    2. B7-H4 gene polymorphisms are associated with sporadic breast cancer in a Chinese Han population. (PubMed id 19903360)1, 4 Zhang J....Li D. (2009)
    3. Identification of a novel susceptibility locus for juvenile idiopathic arthritis by genome-wide association analysis. (PubMed id 19116933)1, 4 Hinks A....Thomson W. (2009)
    4. B7-H4 (DD-O110) is overexpressed in high risk uterine endometrioid adenocarcinomas and inversely correlated with tumor T-cell infiltration. (PubMed id 17509674)1, 2 Miyatake T.... Shroyer K.R. (2007)
    5. B7-H3 and B7-H4 expression in non-small-cell lung cancer. (PubMed id 16782226)1, 2 Sun Y.... Wang X. (2006)
    6. Cutting edge: induction of B7-H4 on APCs through IL-10: novel suppressive mode for regulatory T cells. (PubMed id 16785496)1, 2 Kryczek I....Zou W. (2006)
    7. B7-H4 expression in renal cell carcinoma and tumor vasculature: associations with cancer progression and survival. (PubMed id 16798883)1, 2 Krambeck A.E.... Kwon E.D. (2006)
    8. B7-H4 expression identifies a novel suppressive macrophage population in human ovarian carcinoma. (PubMed id 16606666)1, 2 Kryczek I....Zou W. (2006)
    9. The immunomodulatory protein B7-H4 is overexpressed in breast and ovarian cancers and promotes epithelial cell transformation. (PubMed id 15878339)1, 2 Salceda S.... Papkoff J. (2005)
    10. B7S1, a novel B7 family member that negatively regulates T cell activation. (PubMed id 12818166)1, 3 Prasad D.V....Dong C. (2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 79679 HGNC: 28873 AceView: B7-H4 Ensembl:ENSG00000134258 euGenes: HUgn79679
    ECgene: VTCN1 Kegg: 79679 H-InvDB: VTCN1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for VTCN1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for VTCN1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for VTCN1 gene:
    Search GeneIP for patents involving VTCN1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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