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Aliases for VTCN1 Gene

Aliases for VTCN1 Gene

  • V-Set Domain Containing T Cell Activation Inhibitor 1 2 3
  • Immune Costimulatory Protein B7-H4 3 4
  • T-Cell Costimulatory Molecule B7x 3 4
  • B7 Superfamily Member 1 2 3
  • B7 Homolog 4 3 4
  • B7-H4 3 4
  • B7h.5 3 4
  • B7H4 3 4
  • T Cell Costimulatory Molecule B7x 3
  • B7 Family Member, H4 3
  • B7 Family Member 2
  • Protein B7S1 4
  • PRO1291 3
  • VCTN1 3
  • B7S1 3
  • B7X 3
  • H4 2

External Ids for VTCN1 Gene

Previous GeneCards Identifiers for VTCN1 Gene

  • GC01M117399
  • GC01M117686
  • GC01M115544

Summaries for VTCN1 Gene

Entrez Gene Summary for VTCN1 Gene

  • This gene encodes a protein belonging to the B7 costimulatory protein family. Proteins in this family are present on the surface of antigen-presenting cells and interact with ligand bound to receptors on the surface of T cells. Studies have shown that high levels of the encoded protein has been correlated with tumor progression. A pseudogene of this gene is located on chromosome 20. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

GeneCards Summary for VTCN1 Gene

VTCN1 (V-Set Domain Containing T Cell Activation Inhibitor 1) is a Protein Coding gene. Diseases associated with VTCN1 include renal cell carcinoma. Among its related pathways are NF-kappaB Signaling and Cell adhesion molecules (CAMs). GO annotations related to this gene include receptor binding. An important paralog of this gene is CD276.

UniProtKB/Swiss-Prot for VTCN1 Gene

  • Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor-associated antigen-specific T-cell immunity. Involved in promoting epithelial cell transformation.

Gene Wiki entry for VTCN1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VTCN1 Gene

Genomics for VTCN1 Gene

Regulatory Elements for VTCN1 Gene

Genomic Location for VTCN1 Gene

Chromosome:
1
Start:
117,143,587 bp from pter
End:
117,270,368 bp from pter
Size:
126,782 bases
Orientation:
Minus strand

Genomic View for VTCN1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for VTCN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VTCN1 Gene

Proteins for VTCN1 Gene

  • Protein details for VTCN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z7D3-VTCN1_HUMAN
    Recommended name:
    V-set domain-containing T-cell activation inhibitor 1
    Protein Accession:
    Q7Z7D3
    Secondary Accessions:
    • Q0GN76
    • Q45VN0
    • Q5WPZ3
    • Q6P097
    • Q9H6B2

    Protein attributes for VTCN1 Gene

    Size:
    282 amino acids
    Molecular mass:
    30878 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • May serve as a predictive marker for renal cell carcinoma.

    Three dimensional structures from OCA and Proteopedia for VTCN1 Gene

    Alternative splice isoforms for VTCN1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for VTCN1 Gene

Proteomics data for VTCN1 Gene at MOPED

Post-translational modifications for VTCN1 Gene

Other Protein References for VTCN1 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for VTCN1 (VTCN1)

No data available for DME Specific Peptides for VTCN1 Gene

Domains & Families for VTCN1 Gene

Protein Domains for VTCN1 Gene

Graphical View of Domain Structure for InterPro Entry

Q7Z7D3

UniProtKB/Swiss-Prot:

VTCN1_HUMAN :
  • Contains 2 Ig-like V-type (immunoglobulin-like) domains.
  • Belongs to the immunoglobulin superfamily. BTN/MOG family.
Domain:
  • Contains 2 Ig-like V-type (immunoglobulin-like) domains.
Family:
  • Belongs to the immunoglobulin superfamily. BTN/MOG family.
genes like me logo Genes that share domains with VTCN1: view

Function for VTCN1 Gene

Molecular function for VTCN1 Gene

UniProtKB/Swiss-Prot Function:
Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor-associated antigen-specific T-cell immunity. Involved in promoting epithelial cell transformation.
UniProtKB/Swiss-Prot Induction:
Up-regulated by IL6/interleukin-6 and IL10/interleukin-10 and inhibited by CSF2/GM-CSF and IL4/interleukin-4 on antigen-presenting cells (APCs).

Gene Ontology (GO) - Molecular Function for VTCN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding IEA --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with VTCN1: view
genes like me logo Genes that share phenotypes with VTCN1: view

Animal Models for VTCN1 Gene

MGI Knock Outs for VTCN1:

Animal Model Products

miRNA for VTCN1 Gene

miRTarBase miRNAs that target VTCN1

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for VTCN1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for VTCN1 Gene

Localization for VTCN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for VTCN1 Gene

Cell membrane; Single-pass type I membrane protein. Note=Expressed at the cell surface. A soluble form has also been detected. {ECO:0000255, ECO:0000269 PubMed:12818165, ECO:0000269 PubMed:15878339, ECO:0000269 PubMed:16782226}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for VTCN1 Gene COMPARTMENTS Subcellular localization image for VTCN1 gene
Compartment Confidence
plasma membrane 2
cytosol 1

Gene Ontology (GO) - Cellular Components for VTCN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009897 external side of plasma membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with VTCN1: view

Pathways & Interactions for VTCN1 Gene

genes like me logo Genes that share pathways with VTCN1: view

Pathways by source for VTCN1 Gene

1 Cell Signaling Technology pathway for VTCN1 Gene
1 KEGG pathway for VTCN1 Gene

Interacting Proteins for VTCN1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000358470%0d%0a9606.ENSP00000333919%0d%0a
Selected Interacting proteins: Q7Z7D3-VTCN1_HUMAN ENSP00000358470 for VTCN1 Gene via I2D STRING

Gene Ontology (GO) - Biological Process for VTCN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001562 response to protozoan IEA --
GO:0002250 adaptive immune response IEA --
GO:0042102 positive regulation of T cell proliferation IEA --
GO:0050868 negative regulation of T cell activation IEA --
GO:0072602 interleukin-4 secretion IEA --
genes like me logo Genes that share ontologies with VTCN1: view

No data available for SIGNOR curated interactions for VTCN1 Gene

Drugs & Compounds for VTCN1 Gene

No Compound Related Data Available

Transcripts for VTCN1 Gene

Unigene Clusters for VTCN1 Gene

V-set domain containing T cell activation inhibitor 1:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for VTCN1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for VTCN1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c
SP1: -
SP2: - -
SP3: -
SP4: - - -

Relevant External Links for VTCN1 Gene

GeneLoc Exon Structure for
VTCN1
ECgene alternative splicing isoforms for
VTCN1

Expression for VTCN1 Gene

mRNA expression in normal human tissues for VTCN1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for VTCN1 Gene

This gene is overexpressed in Minor Salivary Gland (x14.9), Breast - Mammary Tissue (x12.4), Pancreas (x9.3), and Kidney - Cortex (x5.1).

Protein differential expression in normal tissues from HIPED for VTCN1 Gene

This gene is overexpressed in Urine (55.1) and Milk (11.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for VTCN1 Gene



SOURCE GeneReport for Unigene cluster for VTCN1 Gene Hs.546434

mRNA Expression by UniProt/SwissProt for VTCN1 Gene

Q7Z7D3-VTCN1_HUMAN
Tissue specificity: Overexpressed in breast, ovarian, endometrial, renal cell (RCC) and non-small-cell lung cancers (NSCLC). Expressed on activated T- and B-cells, monocytes and dendritic cells, but not expressed in most normal tissues (at protein level). Widely expressed, including in kidney, liver, lung, ovary, placenta, spleen and testis.
genes like me logo Genes that share expression patterns with VTCN1: view

Protein tissue co-expression partners for VTCN1 Gene

Primer Products

In Situ Assay Products

Orthologs for VTCN1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for VTCN1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia VTCN1 35
  • 90.07 (n)
  • 90.78 (a)
VTCN1 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia VTCN1 35
  • 91.25 (n)
  • 93.62 (a)
VTCN1 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Vtcn1 35
  • 84.52 (n)
  • 87.94 (a)
Vtcn1 16
Vtcn1 36
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia VTCN1 35
  • 99.53 (n)
  • 99.29 (a)
VTCN1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Vtcn1 35
  • 84.4 (n)
  • 86.88 (a)
oppossum
(Monodelphis domestica)
Mammalia VTCN1 36
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 21 (a)
ManyToMany
chicken
(Gallus gallus)
Aves VTCN1 35
  • 63.37 (n)
  • 59.34 (a)
VTCN1 36
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia vtcn1 35
  • 53.79 (n)
  • 42.05 (a)
zebrafish
(Danio rerio)
Actinopterygii si:dkey-174k18.6 35
  • 50.07 (n)
  • 38.91 (a)
VTCN1 36
  • 34 (a)
OneToOne
Species with no ortholog for VTCN1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for VTCN1 Gene

ENSEMBL:
Gene Tree for VTCN1 (if available)
TreeFam:
Gene Tree for VTCN1 (if available)

Paralogs for VTCN1 Gene

Paralogs for VTCN1 Gene

Pseudogenes.org Pseudogenes for VTCN1 Gene

genes like me logo Genes that share paralogs with VTCN1: view

Variants for VTCN1 Gene

Sequence variations from dbSNP and Humsavar for VTCN1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs13505 -- 117,143,870(-) ACCCT(G/T)CCTGG utr-variant-3-prime, nc-transcript-variant
rs867302 -- 117,162,747(-) GTTTC(A/G)TCTTG intron-variant
rs907661 -- 117,204,472(-) GAGAG(A/T)CCAAG upstream-variant-2KB, intron-variant
rs925512 -- 117,255,983(+) AAAAG(G/T)GAGCA intron-variant
rs925513 -- 117,235,605(-) GTCAC(C/T)GAAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for VTCN1 Gene

Variant ID Type Subtype PubMed ID
esv2716640 CNV Deletion 23290073

Variation tolerance for VTCN1 Gene

Residual Variation Intolerance Score: 66.22% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.35; 41.79% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for VTCN1 Gene

HapMap Linkage Disequilibrium report
VTCN1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VTCN1 Gene

Disorders for VTCN1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for VTCN1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
renal cell carcinoma
  • renal cell carcinoma, clear cell, somatic
- elite association
Search VTCN1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for VTCN1

Genetic Association Database (GAD)
VTCN1
Human Genome Epidemiology (HuGE) Navigator
VTCN1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
VTCN1
genes like me logo Genes that share disorders with VTCN1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for VTCN1 Gene

Publications for VTCN1 Gene

  1. B7S1, a novel B7 family member that negatively regulates T cell activation. (PMID: 12818166) Prasad D.V. … Dong C. (Immunity 2003) 2 67
  2. B7-H4, a molecule of the B7 family, negatively regulates T cell immunity. (PMID: 12818165) Sica G.L. … Chen L. (Immunity 2003) 2 67
  3. Cancer cell-associated cytoplasmic B7-H4 is induced by hypoxia through hypoxia-inducible factor-1I+ and promotes cancer cell proliferation. (PMID: 25725157) Jeon Y.K. … Choi I. (Biochem. Biophys. Res. Commun. 2015) 67
  4. Diagnostic value of serum B7-H4 for hepatocellular carcinoma. (PMID: 25963168) Zhang C. … Wang Y. (J. Surg. Res. 2015) 67
  5. B7-H4 expression in normal and diseased human islet I^ cells. (PMID: 24326367) Cheung S.S. … Warnock G.L. (Pancreas 2014) 67

Products for VTCN1 Gene

Sources for VTCN1 Gene

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