Aliases for VTA1 Gene
External Ids for VTA1 Gene
Previous HGNC Symbols for VTA1 Gene
Previous GeneCards Identifiers for VTA1 Gene
C6ORF55 encodes a protein involved in trafficking of the multivesicular body, an endosomal compartment involved in sorting membrane proteins for degradation in lysosomes (Ward et al., 2005 [PubMed 15644320]).[supplied by OMIM, Mar 2008]
GeneCards Summary for VTA1 Gene
VTA1 (Vesicle Trafficking 1) is a Protein Coding gene. Diseases associated with VTA1 include Amyotrophic Lateral Sclerosis 15, With Or Without Frontotemporal Dementia and Amyotrophic Lateral Sclerosis 9. Among its related pathways are HIV Life Cycle and Budding and maturation of HIV virion. GO annotations related to this gene include protein C-terminus binding.
UniProtKB/Swiss-Prot for VTA1 Gene
Involved in the endosomal multivesicular bodies (MVB) pathway. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. Thought to be a cofactor of VPS4A/B, which catalyzes disassembles membrane-associated ESCRT-III assemblies. Involved in the sorting and down-regulation of EGFR (By similarity). Involved in HIV-1 budding.