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VTA1 Gene

protein-coding   GIFtS: 59
GCID: GC06P142468

Vesicle (Multivesicular Body) Trafficking 1

(Previous names: chromosome 6 open reading frame 55, Vps20-associated 1 homolog...)
(Previous symbol: C6orf55)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Vesicle (Multivesicular Body) Trafficking 11 2     DRG12 5
C6orf551 2 3 5     Chromosome 6 Open Reading Frame 551
LIP52 3 5     Vps20-Associated 1 Homolog (S. Cerevisiae)1
SBP12 3 5     My0122
Dopamine-Responsive Gene 1 Protein2 3     Homolog Of Mouse SKD1-Binding Protein 12
DRG-12 3     Vacuolar Protein Sorting-Associated Protein VTA1 Homolog2
LYST-Interacting Protein 52 3     Vps20-Associated 1 Homolog2
SKD1-Binding Protein 12 3     

External Ids:    HGNC: 209541   Entrez Gene: 515342   Ensembl: ENSG000000098447   OMIM: 6109025   UniProtKB: Q9NP793   

Export aliases for VTA1 gene to outside databases

Previous GC identifers: GC06P142511 GC06P140034


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for VTA1 Gene:
C6ORF55 encodes a protein involved in trafficking of the multivesicular body, an endosomal compartment involved in
sorting membrane proteins for degradation in lysosomes (Ward et al., 2005 (PubMed 15644320)).(supplied by OMIM,
Mar 2008)

GeneCards Summary for VTA1 Gene:
VTA1 (vesicle (multivesicular body) trafficking 1) is a protein-coding gene.

UniProtKB/Swiss-Prot: VTA1_HUMAN, Q9NP79
Function: Involved in the endosomal multivesicular bodies (MVB) pathway. MVBs contain intraluminal vesicles (ILVs)
that are generated by invagination and scission from the limiting membrane of the endosome and mostly are
delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors,
lysosomal enzymes and lipids. Thought to be a cofactor of VPS4A/B, which catalyzes disassembles
membrane-associated ESCRT-III assemblies. Involved in the sorting and down-regulation of EGFR (By similarity).
Involved in HIV-1 budding

Gene Wiki entry for VTA1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NC_018917.2  NT_025741.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the VTA1 gene promoter:
         AP-1   ATF-2   CUTL1   Egr-2   Max   SRY   HFH-1   c-Jun   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidVTA1 promoter sequence
   Search Chromatin IP Primers for VTA1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat VTA1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q24.1   Ensembl cytogenetic band:  6q24.1   HGNC cytogenetic band: 6q24.1

VTA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
VTA1 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P142468:  view genomic region     (about GC identifiers)

Start:
142,468,367 bp from pter      End:
142,545,826 bp from pter
Size:
77,460 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: VTA1_HUMAN, Q9NP79 (See protein sequence)
Recommended Name: Vacuolar protein sorting-associated protein VTA1 homolog  
Size: 307 amino acids; 33879 Da
Subunit: Interacts with VPS4B. Interacts with CHMP1B. Interacts with CHMP2A; the interaction probably involves the
open conformation of (polymerized) CHMP2A. Interacts with CHMP3. Interacts with CHMP5; the interaction involves
soluble CHMP5. Interacts with IST1
Sequence caution: Sequence=AAF36148.1; Type=Frameshift; Positions=131, 140; Sequence=AAG43125.1; Type=Frameshift;
Positions=269;
2 PDB 3D structures from and Proteopedia for VTA1:
2LXL (3D)        2LXM (3D)    
Secondary accessions: E1P594 Q5TGM1 Q6IAE8 Q9H0R2 Q9H3K9 Q9P0Q0

Explore the universe of human proteins at neXtProt for VTA1: NX_Q9NP79

Explore proteomics data for VTA1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys277
  • Modification sites at PhosphoSitePlus

  • See VTA1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001273300.1  NP_001273301.1  NP_057569.2  

    ENSEMBL proteins: 
     ENSP00000356602   ENSP00000356593   ENSP00000395767  
    Reactome Protein details: Q9NP79

    VTA1 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR023175 VPS_Vta1/CALS_N-dom

    Graphical View of Domain Structure for InterPro Entry Q9NP79

    ProtoNet protein and cluster: Q9NP79

    UniProtKB/Swiss-Prot: VTA1_HUMAN, Q9NP79
    Similarity: Belongs to the VTA1 family


    Find genes that share domains with VTA1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: VTA1_HUMAN, Q9NP79
    Function: Involved in the endosomal multivesicular bodies (MVB) pathway. MVBs contain intraluminal vesicles (ILVs)
    that are generated by invagination and scission from the limiting membrane of the endosome and mostly are
    delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors,
    lysosomal enzymes and lipids. Thought to be a cofactor of VPS4A/B, which catalyzes disassembles
    membrane-associated ESCRT-III assemblies. Involved in the sorting and down-regulation of EGFR (By similarity).
    Involved in HIV-1 budding

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI19129479
         
    Find genes that share ontologies with VTA1           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for VTA1

    miRNA
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    miRTarBase miRNAs that target VTA1:
    hsa-mir-615-3p (MIRT040302), hsa-mir-605-5p (MIRT040480), hsa-mir-455-5p (MIRT040743), hsa-mir-34a-5p (MIRT025534)

    Block miRNA regulation of human, mouse, rat VTA1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate VTA1 (see all 25):
    hsa-miR-582-3p hsa-miR-485-5p hsa-miR-1288 hsa-miR-520d-5p hsa-miR-657 hsa-miR-29a hsa-miR-29c hsa-miR-3167
    SwitchGear 3'UTR luciferase reporter plasmidVTA1 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    VTA1_HUMAN, Q9NP79: Cytoplasm. Endosome membrane; Peripheral membrane protein (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endosome5
    cytosol4
    mitochondrion1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005829cytosol TAS--
    GO:0010008endosome membrane IEA--
    GO:0070062extracellular vesicular exosome IDA19056867

    Find genes that share ontologies with VTA1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for VTA1 About    
    See pathways by source

    SuperPathContained pathways About
    1HIV Life Cycle
    HIV Life Cycle0.91
    HIV Infection0.62
    Late Phase of HIV Life Cycle0.91
    2Budding and maturation of HIV virion
    Budding and maturation of HIV virion0.64
    Endosomal Sorting Complex Required For Transport (ESCRT)0.64
    3Clathrin derived vesicle budding
    Membrane Trafficking0.32
    4Endocytosis
    Endocytosis
    5Disease
    Disease


    Find genes that share SuperPaths with VTA1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    2 Reactome Pathways for VTA1
        Budding and maturation of HIV virion
    Endosomal Sorting Complex Required For Transport (ESCRT)


    1 Kegg Pathway  (Kegg details for VTA1):
        Endocytosis

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for VTA1
    Interactions:

        Search GeneGlobe Interaction Network for VTA1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for VTA1 (Q9NP792, 3 ENSP000003566024) via UniProtKB, MINT, STRING, and/or I2D (see all 57)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KLHL12Q53G592, 3, ENSP000003562304MINT-67365 I2D: score=5 STRING: ENSP00000356230
    MBIPQ9NS732, 3, ENSP000003244444MINT-67363 I2D: score=5 STRING: ENSP00000324444
    NBR1Q145962, 3, ENSP000003434794MINT-66288 I2D: score=5 STRING: ENSP00000343479
    DPPA2Q7Z7J52, 3MINT-67404 I2D: score=4 
    ZBTB16Q055162, 3, ENSP000003381574MINT-67258 I2D: score=5 STRING: ENSP00000338157
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0015031protein transport IEA--
    GO:0016032viral process TAS--
    GO:0016197endosomal transport TAS--
    GO:0019058viral life cycle TAS--
    GO:0061024membrane organization TAS--

    Find genes that share ontologies with VTA1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for VTA1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for VTA1 gene (3 alternative transcripts): 
    NM_001286371.1  NM_001286372.1  NM_016485.4  

    Unigene Cluster for VTA1:

    Vps20-associated 1 homolog (S. cerevisiae)
    Hs.431367  [show with all ESTs]
    Unigene Representative Sequence: NM_016485
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000367630(uc003qiw.3 uc011edu.2) ENST00000367621 ENST00000491881
    ENST00000452973
    miRNA
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    hsa-miR-582-3p hsa-miR-485-5p hsa-miR-1288 hsa-miR-520d-5p hsa-miR-657 hsa-miR-29a hsa-miR-29c hsa-miR-3167
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      QuantiFast Probe-based Assays in human, mouse, rat VTA1

    Additional mRNA sequence: 

    AF060225.1 AF141341.1 AF151062.1 AF271994.1 AJ420507.1 AK000051.1 AK125691.1 AK130738.1 
    AK301376.1 AL136684.1 AY007093.1 BC005937.1 BC006989.1 BC013217.1 BC022536.1 CR457207.1 

    16 DOTS entries:

    DT.449948  DT.100756521  DT.101957890  DT.100826521  DT.95159954  DT.100826524  DT.95159946  DT.101955139 
    DT.91712844  DT.100724017  DT.100767142  DT.95159940  DT.99929161  DT.100000855  DT.100826513  DT.121367203 

    Selected AceView cDNA sequences (see all 409):

    BP344598 CA443887 Z43113 CA442355 BU689260 BX459710 BU675787 AA897677 
    AW612494 AA748010 BG941834 N91850 BP381542 CR606694 BQ010169 NM_016485 
    BM454291 AI280470 CK824116 BF109209 AI493837 BU633356 BF221841 AI057501 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for VTA1    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b
    SP1:                                                                                    
    SP2:                                            -                                       
    SP3:                                                                    -               
    SP4:                                                  -                                 


    ECgene alternative splicing isoforms for VTA1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    VTA1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATTTTTGGC
    VTA1 Expression
    About this image


    VTA1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Ovary (Reproductive System)
             Oviduct
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
    VTA1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    VTA1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.431367
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VTA1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for VTA1 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Vta11 , 5 Vps20-associated 1 homolog (S. cerevisiae)1, 5 87.76(n)1
    91.84(a)1
      10 (5.50 cM)5
    662011  NM_025418.31  NP_079694.21 
     146547555 
    chicken
    (Gallus gallus)
    Aves VTA11 Vps20-associated 1 homolog (S. cerevisiae) 77.97(n)
    80.68(a)
      421674  XM_419713.4  XP_419713.3 
    lizard
    (Anolis carolinensis)
    Reptilia VTA16
    vesicle (multivesicular body) trafficking 1
    81(a)
    1 ↔ 1
    1(203087688-203138427)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.226402 Xenopus laevis transcribed sequence with moderate similarity more 79.76(n)    BU912837.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb08c112 Danio rerio cDNA clone MGC64104 IMAGE6795098, complete more 78.24(n)    BC053254.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG79671 CG7967 52.07(n)
    49.66(a)
      38204  NM_139383.2  NP_647640.1 
    worm
    (Caenorhabditis elegans)
    Secernentea T23G11.71 T23G11.7 52.87(n)
    41.76(a)
      172528  NM_059738.5  NP_492139.3 


    ENSEMBL Gene Tree for VTA1 (if available)
    TreeFam Gene Tree for VTA1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for VTA1 gene

    Find genes that share paralogs with VTA1           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for VTA1
    PGOHUM00000243461 PGOHUM00000249422


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for VTA1 (see all 1463)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1902467161,2
    --142466531(+) AAACCA/CAAATA 1 -- us2k10--------
    rs1824254571,2
    --142466550(+) TTAATC/GTGGAA 1 -- us2k10--------
    rs1411115481,2
    --142466558(+) GAATAC/TTCATC 1 -- us2k10--------
    rs1865414051,2
    --142466598(+) CTAGAG/TTCTAT 1 -- us2k10--------
    rs735798011,2
    C,F--142466603(+) TTCTAT/CGTGTC 1 -- us2k12Minor allele frequency- C:0.04WA 120
    rs1469387741,2
    --142466620(+) TTCTCA/TTCTGT 1 -- us2k10--------
    rs735816041,2
    C,F--142466654(+) ATAGGG/TTTGTG 1 -- us2k11Minor allele frequency- T:0.50WA 2
    rs1379814881,2
    --142466736(+) TGCTAG/TCTAGT 1 -- us2k10--------
    rs760119851,2
    C--142466756(+) TTTAA-/GTTGTG 1 -- us2k10--------
    rs1831593301,2
    --142466808(+) AATCTC/TAATAG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for VTA1 (142468367 - 142545826 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for VTA1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2065068CNV Deletion18987734
    esv2574651CNV Deletion19546169
    nsv5510CNV Insertion18451855
    dgv7004n71CNV Loss21882294
    nsv886735CNV Loss21882294
    nsv830824CNV Gain17160897
    dgv7003n71CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610902    OMIM disorders: --


    Find genes that share disorders with VTA1           About GenesLikeMe

    Genetic Association Database (GAD): VTA1
    Human Genome Epidemiology (HuGE) Navigator: VTA1 (1 document)

    Export disorders for VTA1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for VTA1 gene, integrated from 10 sources (see all 42):
    (articles sorted by number of sources associating them with VTA1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The role of LIP5 and CHMP5 in multivesicular body formation and HIV-1 budding in mammalian cells. (PubMed id 15644320)1, 2, 3 Ward D.M.... Kaplan J. (J. Biol. Chem. 2005)
    2. Mechanism of inhibition of retrovirus release from cells by interferon-induced gene ISG15. (PubMed id 21543490)1, 2 Kuang Z....Leis J. (J. Virol. 2011)
    3. Four novel Loci (19q13, 6q24, 12q24, and 5q14) influence the microcirculation in vivo. (PubMed id 21060863)1, 4 Ikram M.K....Wong T.Y. (PLoS Genet. 2010)
    4. Essential role of hIST1 in cytokinesis. (PubMed id 19129480)1, 2 Agromayor M.... Martin-Serrano J. (Mol. Biol. Cell 2009)
    5. Biochemical analyses of human IST1 and its function in cytokinesis. (PubMed id 19129479)1, 2 Bajorek M....Sundquist W.I. (Mol. Biol. Cell 2009)
    6. Targeting of AMSH to endosomes is required for epidermal growth factor receptor degradation. (PubMed id 17261583)1, 2 Ma Y.M.... Kirchhausen T. (J. Biol. Chem. 2007)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (Genome Res. 2001)
    10. Identification of dopamine responsive mRNAs in glial cells by suppression subtractive hybridization. (PubMed id 11489251)1, 3 Shi J.... Xie Y. (Brain Res. 2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 51534 HGNC: 20954 AceView: C6orf55 Ensembl:ENSG00000009844 euGenes: HUgn51534
    ECgene: VTA1 Kegg: 51534 H-InvDB: VTA1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for VTA1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for VTA1 gene:
    Search GeneIP for patents involving VTA1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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