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Aliases for VSTM5 Gene

Aliases for VSTM5 Gene

  • V-Set And Transmembrane Domain Containing 5 2 3 5
  • C11orf90 3 4
  • V-Set And Transmembrane Domain-Containing Protein 5 3
  • Chromosome 11 Open Reading Frame 90 2

External Ids for VSTM5 Gene

Previous HGNC Symbols for VSTM5 Gene

  • C11orf90

Previous GeneCards Identifiers for VSTM5 Gene

  • GC11M093552
  • GC11M093554
  • GC11M093570

Summaries for VSTM5 Gene

GeneCards Summary for VSTM5 Gene

VSTM5 (V-Set And Transmembrane Domain Containing 5) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VSTM5 Gene

Genomics for VSTM5 Gene

Regulatory Elements for VSTM5 Gene

Enhancers for VSTM5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F093814 0.4 ENCODE 12 +35.3 35289 1.9 POLR2A HLF C11orf54 VSTM5 MED17 MIR1304 TAF1D GC11P093800 GC11P093828
GH11F093817 0.5 ENCODE 12 +32.9 32928 0.8 C11orf54 VSTM5 MED17 MIR1304 TAF1D GC11P093828 GC11P093800
GH11F093818 0.2 ENCODE 12 +32.4 32402 0.2 VSTM5 MED17 MIR1304 TAF1D GC11P093828 GC11P093800
GH11F093849 1.1 ENCODE 9.2 +0.5 548 1.4 HDAC1 PKNOX1 TAL1 ZNF48 CCNT2 NCOR1 ZNF740 BHLHE40 ARID1B ZNF318 VSTM5 PANX1 ENSG00000206911
GH11F093850 0.2 ENCODE 0.8 -0.2 -249 0.1 HDAC1 PKNOX1 ZNF740 ZKSCAN8 ID3 NR2C2 VSTM5 LOC101060084
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around VSTM5 on UCSC Golden Path with GeneCards custom track

Promoters for VSTM5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001771101 131 1200 HDAC1 CTCF PKNOX1 TAL1 CCNT2 NCOR1 ZNF740 NR2F1 ARID1B ZNF318

Genomic Location for VSTM5 Gene

Chromosome:
11
Start:
93,818,232 bp from pter
End:
93,850,531 bp from pter
Size:
32,300 bases
Orientation:
Minus strand

Genomic View for VSTM5 Gene

Genes around VSTM5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
VSTM5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for VSTM5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VSTM5 Gene

Proteins for VSTM5 Gene

  • Protein details for VSTM5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A8MXK1-VSTM5_HUMAN
    Recommended name:
    V-set and transmembrane domain-containing protein 5
    Protein Accession:
    A8MXK1

    Protein attributes for VSTM5 Gene

    Size:
    200 amino acids
    Molecular mass:
    22377 Da
    Quaternary structure:
    No Data Available

neXtProt entry for VSTM5 Gene

Post-translational modifications for VSTM5 Gene

  • Glycosylation at Asn 102
  • Modification sites at PhosphoSitePlus

Other Protein References for VSTM5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for VSTM5 Gene

Domains & Families for VSTM5 Gene

Gene Families for VSTM5 Gene

Protein Domains for VSTM5 Gene

Graphical View of Domain Structure for InterPro Entry

A8MXK1

UniProtKB/Swiss-Prot:

VSTM5_HUMAN :
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
Domain:
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
genes like me logo Genes that share domains with VSTM5: view

No data available for Suggested Antigen Peptide Sequences for VSTM5 Gene

Function for VSTM5 Gene

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for VSTM5 Gene

Localization for VSTM5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for VSTM5 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for VSTM5 Gene COMPARTMENTS Subcellular localization image for VSTM5 gene
Compartment Confidence
plasma membrane 3
extracellular 1

Gene Ontology (GO) - Cellular Components for VSTM5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with VSTM5: view

Pathways & Interactions for VSTM5 Gene

SuperPathways for VSTM5 Gene

No Data Available

Interacting Proteins for VSTM5 Gene

Gene Ontology (GO) - Biological Process for VSTM5 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for VSTM5 Gene

Transcripts for VSTM5 Gene

mRNA/cDNA for VSTM5 Gene

(1) REFSEQ mRNAs :
(0) Additional mRNA sequences :
-
(6) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for VSTM5 Gene

V-set and transmembrane domain containing 5:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for VSTM5 Gene

No ASD Table

Relevant External Links for VSTM5 Gene

GeneLoc Exon Structure for
VSTM5
ECgene alternative splicing isoforms for
VSTM5

Expression for VSTM5 Gene

mRNA expression in normal human tissues for VSTM5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for VSTM5 Gene

This gene is overexpressed in Brain - Hypothalamus (x6.8), Brain - Frontal Cortex (BA9) (x6.1), Brain - Cortex (x6.0), and Brain - Anterior cingulate cortex (BA24) (x4.2).

NURSA nuclear receptor signaling pathways regulating expression of VSTM5 Gene:

VSTM5

SOURCE GeneReport for Unigene cluster for VSTM5 Gene:

Hs.512252
genes like me logo Genes that share expression patterns with VSTM5: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for VSTM5 Gene

Orthologs for VSTM5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for VSTM5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia VSTM5 34 35
  • 86.33 (n)
rat
(Rattus norvegicus)
Mammalia Vstm5 34
  • 81.74 (n)
mouse
(Mus musculus)
Mammalia Vstm5 34 16 35
  • 81.07 (n)
dog
(Canis familiaris)
Mammalia VSTM5 34 35
  • 80 (n)
oppossum
(Monodelphis domestica)
Mammalia VSTM5 35
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia VSTM5 35
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves VSTM5 34 35
  • 66.16 (n)
lizard
(Anolis carolinensis)
Reptilia VSTM5 35
  • 47 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia vstm5 34
  • 58.33 (n)
zebrafish
(Danio rerio)
Actinopterygii VSTM5 35
  • 32 (a)
OneToOne
Species where no ortholog for VSTM5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for VSTM5 Gene

ENSEMBL:
Gene Tree for VSTM5 (if available)
TreeFam:
Gene Tree for VSTM5 (if available)

Paralogs for VSTM5 Gene

No data available for Paralogs for VSTM5 Gene

Variants for VSTM5 Gene

Sequence variations from dbSNP and Humsavar for VSTM5 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs10566414 -- 93,843,459(+) GTACC(-/TGAA)TGAAT intron-variant
rs10623760 -- 93,846,200(+) ATAGT(-/AA)AAGTT intron-variant
rs10627039 -- 93,837,011(+) AAATG(-/CA/CACA/CACACA)CACAC intron-variant
rs10659757 -- 93,838,187(+) TTAAA(-/AAAC)AAAGT intron-variant
rs10765635 -- 93,837,838(+) ACACC(C/G)ATAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for VSTM5 Gene

Variant ID Type Subtype PubMed ID
dgv695n106 CNV deletion 24896259
esv1952279 CNV deletion 18987734
esv2744923 CNV deletion 23290073
esv2744924 CNV deletion 23290073
esv3250 CNV loss 18987735
esv3548173 CNV deletion 23714750
esv3627294 CNV gain 21293372
esv3627296 CNV loss 21293372
esv3892068 CNV gain 25118596
nsv1122656 CNV deletion 24896259
nsv1147650 CNV deletion 26484159
nsv826039 CNV loss 20364138
nsv957223 CNV deletion 24416366

Variation tolerance for VSTM5 Gene

Gene Damage Index Score: 3.50; 55.35% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for VSTM5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
VSTM5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VSTM5 Gene

Disorders for VSTM5 Gene

Relevant External Links for VSTM5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
VSTM5

No disorders were found for VSTM5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for VSTM5 Gene

Publications for VSTM5 Gene

  1. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor T.D. … Sakaki Y. (Nature 2006) 2 3 4 64

Products for VSTM5 Gene

Sources for VSTM5 Gene

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