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Aliases for VSTM5 Gene

Aliases for VSTM5 Gene

  • V-Set And Transmembrane Domain Containing 5 2 3 5
  • C11orf90 3 4
  • V-Set And Transmembrane Domain-Containing Protein 5 3
  • Chromosome 11 Open Reading Frame 90 2

External Ids for VSTM5 Gene

Previous HGNC Symbols for VSTM5 Gene

  • C11orf90

Previous GeneCards Identifiers for VSTM5 Gene

  • GC11M093552
  • GC11M093554
  • GC11M093570

Summaries for VSTM5 Gene

GeneCards Summary for VSTM5 Gene

VSTM5 (V-Set And Transmembrane Domain Containing 5) is a Protein Coding gene.

UniProtKB/Swiss-Prot for VSTM5 Gene

  • Cell adhesion-like membrane protein of the central nervous system (CNS) which modulates both the position and complexity of central neurons by altering their membrane morphology and dynamics. Involved in the formation of neuronal dendrites and protrusions including dendritic filopodia. In synaptogenesis, regulates synapse formation by altering dendritic spine morphology and actin distribution. Promotes formation of unstable neuronal spines such as thin and branched types. Regulates neuronal morphogenesis and migration during cortical development in the brain.

Additional gene information for VSTM5 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VSTM5 Gene

Genomics for VSTM5 Gene

GeneHancer (GH) Regulatory Elements for VSTM5 Gene

Promoters and enhancers for VSTM5 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I093849 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE 559.2 +0.5 459 1.5 SMARCE1 CTCF HDAC1 ZNF740 TEAD4 BHLHE40 CBFA2T3 ZNF48 CCNT2 NFIC VSTM5 PANX1 ENSG00000206911
GH11I093814 Enhancer 0.3 ENCODE 12 +35.3 35289 1.9 POLR2A C11orf54 VSTM5 TAF1D MED17 GC11P093800 GC11P093828
GH11I093817 Enhancer 0.2 ENCODE 12 +32.9 32927 0.8 C11orf54 VSTM5 TAF1D MED17 GC11P093828 GC11P093800
GH11I093818 Enhancer 0.2 ENCODE 12 +32.4 32401 0.2 VSTM5 TAF1D MED17 GC11P093828 GC11P093800
GH11I093842 Enhancer 0.7 ENCODE 0.4 +7.9 7901 0.2 TEAD4 TAL1 JUN MAX FOSL1 TCF12 CCNT2 NCOR1 CHD2 SMARCE1 VSTM5 ENSG00000206911
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around VSTM5 on UCSC Golden Path with GeneCards custom track

Genomic Locations for VSTM5 Gene

Genomic Locations for VSTM5 Gene
chr11:93,818,232-93,850,531
(GRCh38/hg38)
Size:
32,300 bases
Orientation:
Minus strand
chr11:93,551,398-93,583,697
(GRCh37/hg19)

Genomic View for VSTM5 Gene

Genes around VSTM5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
VSTM5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for VSTM5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VSTM5 Gene

Proteins for VSTM5 Gene

  • Protein details for VSTM5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A8MXK1-VSTM5_HUMAN
    Recommended name:
    V-set and transmembrane domain-containing protein 5
    Protein Accession:
    A8MXK1

    Protein attributes for VSTM5 Gene

    Size:
    200 amino acids
    Molecular mass:
    22377 Da
    Quaternary structure:
    • Can homooligomerize through cis interactions within the same cell membrane.

neXtProt entry for VSTM5 Gene

Post-translational modifications for VSTM5 Gene

Other Protein References for VSTM5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for VSTM5 Gene

Domains & Families for VSTM5 Gene

Gene Families for VSTM5 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for VSTM5 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with VSTM5: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for VSTM5 Gene

Function for VSTM5 Gene

Molecular function for VSTM5 Gene

UniProtKB/Swiss-Prot Function:
Cell adhesion-like membrane protein of the central nervous system (CNS) which modulates both the position and complexity of central neurons by altering their membrane morphology and dynamics. Involved in the formation of neuronal dendrites and protrusions including dendritic filopodia. In synaptogenesis, regulates synapse formation by altering dendritic spine morphology and actin distribution. Promotes formation of unstable neuronal spines such as thin and branched types. Regulates neuronal morphogenesis and migration during cortical development in the brain.

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for VSTM5 Gene

Localization for VSTM5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for VSTM5 Gene

Cell membrane; Single-pass type I membrane protein. Cell projection, dendrite. Cell projection, axon.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for VSTM5 gene
Compartment Confidence
plasma membrane 5
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for VSTM5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane ISS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane ISS --
GO:0030424 axon ISS --
GO:0030425 dendrite ISS --
genes like me logo Genes that share ontologies with VSTM5: view

Pathways & Interactions for VSTM5 Gene

SuperPathways for VSTM5 Gene

No Data Available

Interacting Proteins for VSTM5 Gene

Gene Ontology (GO) - Biological Process for VSTM5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development IEA --
GO:0021517 ventral spinal cord development IEA --
GO:0046847 filopodium assembly ISS,IEA --
GO:0051260 protein homooligomerization ISS,IEA --
GO:1904891 positive regulation of excitatory synapse assembly ISS,IEA --
genes like me logo Genes that share ontologies with VSTM5: view

No data available for Pathways by source and SIGNOR curated interactions for VSTM5 Gene

Drugs & Compounds for VSTM5 Gene

No Compound Related Data Available

Transcripts for VSTM5 Gene

mRNA/cDNA for VSTM5 Gene

(1) REFSEQ mRNAs :
(0) Additional mRNA sequences :
-
(6) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for VSTM5 Gene

V-set and transmembrane domain containing 5:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for VSTM5 Gene

No ASD Table

Relevant External Links for VSTM5 Gene

GeneLoc Exon Structure for
VSTM5
ECgene alternative splicing isoforms for
VSTM5

Expression for VSTM5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for VSTM5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for VSTM5 Gene

This gene is overexpressed in Brain - Hypothalamus (x6.8), Brain - Frontal Cortex (BA9) (x6.1), Brain - Cortex (x6.0), and Brain - Anterior cingulate cortex (BA24) (x4.2).

NURSA nuclear receptor signaling pathways regulating expression of VSTM5 Gene:

VSTM5

SOURCE GeneReport for Unigene cluster for VSTM5 Gene:

Hs.512252
genes like me logo Genes that share expression patterns with VSTM5: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for VSTM5 Gene

Orthologs for VSTM5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for VSTM5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia VSTM5 33 34
  • 86.33 (n)
rat
(Rattus norvegicus)
Mammalia Vstm5 33
  • 81.74 (n)
mouse
(Mus musculus)
Mammalia Vstm5 33 16 34
  • 81.07 (n)
dog
(Canis familiaris)
Mammalia VSTM5 33 34
  • 80 (n)
oppossum
(Monodelphis domestica)
Mammalia VSTM5 34
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia VSTM5 34
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves VSTM5 33 34
  • 66.16 (n)
lizard
(Anolis carolinensis)
Reptilia VSTM5 34
  • 47 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia vstm5 33
  • 58.33 (n)
zebrafish
(Danio rerio)
Actinopterygii VSTM5 34
  • 32 (a)
OneToOne
Species where no ortholog for VSTM5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for VSTM5 Gene

ENSEMBL:
Gene Tree for VSTM5 (if available)
TreeFam:
Gene Tree for VSTM5 (if available)

Paralogs for VSTM5 Gene

No data available for Paralogs for VSTM5 Gene

Variants for VSTM5 Gene

Sequence variations from dbSNP and Humsavar for VSTM5 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000120295 -- 93,850,833(-) A/T upstream_transcript_variant
rs1000187537 -- 93,849,362(-) G/A intron_variant
rs1000270798 -- 93,826,407(-) TTTTTTTTT/TTTTTTTTTT intron_variant
rs1000316950 -- 93,838,794(-) T/C intron_variant
rs1000319998 -- 93,843,134(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for VSTM5 Gene

Variant ID Type Subtype PubMed ID
dgv695n106 CNV deletion 24896259
esv1952279 CNV deletion 18987734
esv2744923 CNV deletion 23290073
esv2744924 CNV deletion 23290073
esv3250 CNV loss 18987735
esv3548173 CNV deletion 23714750
esv3627294 CNV gain 21293372
esv3627296 CNV loss 21293372
esv3892068 CNV gain 25118596
nsv1122656 CNV deletion 24896259
nsv1147650 CNV deletion 26484159
nsv826039 CNV loss 20364138
nsv957223 CNV deletion 24416366

Variation tolerance for VSTM5 Gene

Gene Damage Index Score: 3.50; 55.35% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for VSTM5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
VSTM5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VSTM5 Gene

Disorders for VSTM5 Gene

Additional Disease Information for VSTM5

No disorders were found for VSTM5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for VSTM5 Gene

Publications for VSTM5 Gene

  1. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor TD … Sakaki Y (Nature 2006) 2 3 4 58

Products for VSTM5 Gene

Sources for VSTM5 Gene

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