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Aliases for VSTM4 Gene

Aliases for VSTM4 Gene

  • V-Set And Transmembrane Domain Containing 4 2 3
  • C10orf72 3 4
  • Chromosome 10 Open Reading Frame 72 2

External Ids for VSTM4 Gene

Previous HGNC Symbols for VSTM4 Gene

  • C10orf72

Previous GeneCards Identifiers for VSTM4 Gene

  • GC10M050223

Summaries for VSTM4 Gene

GeneCards Summary for VSTM4 Gene

VSTM4 (V-Set And Transmembrane Domain Containing 4) is a Protein Coding gene.

UniProtKB/Swiss-Prot for VSTM4 Gene

  • Peptide Lv enhances L-type voltage-gated calcium channel (L-VGCC) currents in retinal photoreceptors.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VSTM4 Gene

Genomics for VSTM4 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for VSTM4 Gene

Chromosome:
10
Start:
49,014,245 bp from pter
End:
49,129,144 bp from pter
Size:
114,900 bases
Orientation:
Minus strand

Genomic View for VSTM4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for VSTM4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VSTM4 Gene

No data available for Regulatory Elements for VSTM4 Gene

Proteins for VSTM4 Gene

  • Protein details for VSTM4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IW00-VSTM4_HUMAN
    Recommended name:
    V-set and transmembrane domain-containing protein 4
    Protein Accession:
    Q8IW00
    Secondary Accessions:
    • B4DNI6
    • Q96MX7

    Protein attributes for VSTM4 Gene

    Size:
    320 amino acids
    Molecular mass:
    36146 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for VSTM4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for VSTM4 Gene

Proteomics data for VSTM4 Gene at MOPED

Post-translational modifications for VSTM4 Gene

  • Proteolytically cleaved to generate a bioactive peptide.
  • Glycosylation at Asn 25, Asn 41, Asn 89, and Asn 144
  • Modification sites at PhosphoSitePlus

Other Protein References for VSTM4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for VSTM4 Gene

Domains & Families for VSTM4 Gene

Gene Families for VSTM4 Gene

Protein Domains for VSTM4 Gene

Suggested Antigen Peptide Sequences for VSTM4 Gene

Graphical View of Domain Structure for InterPro Entry

Q8IW00

UniProtKB/Swiss-Prot:

VSTM4_HUMAN :
  • Contains 1 Ig-like (immunoglobulin-like) domain.
Domain:
  • Contains 1 Ig-like (immunoglobulin-like) domain.
genes like me logo Genes that share domains with VSTM4: view

Function for VSTM4 Gene

Molecular function for VSTM4 Gene

UniProtKB/Swiss-Prot Function:
Peptide Lv enhances L-type voltage-gated calcium channel (L-VGCC) currents in retinal photoreceptors.

Gene Ontology (GO) - Molecular Function for VSTM4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with VSTM4: view
genes like me logo Genes that share phenotypes with VSTM4: view

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for VSTM4

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for VSTM4 Gene

Localization for VSTM4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for VSTM4 Gene

Peptide Lv: Secreted.
Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for VSTM4 Gene COMPARTMENTS Subcellular localization image for VSTM4 gene
Compartment Confidence
extracellular 3
plasma membrane 3

Gene Ontology (GO) - Cellular Components for VSTM4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005886 plasma membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with VSTM4: view

Pathways & Interactions for VSTM4 Gene

SuperPathways for VSTM4 Gene

No Data Available

Interacting Proteins for VSTM4 Gene

STRING Interaction Network Preview (showing 4 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000331062%0d%0a9606.ENSP00000356191%0d%0a9606.ENSP00000410294%0d%0a9606.ENSP00000331210%0d%0a9606.ENSP00000282397%0d%0a
Selected Interacting proteins: ENSP00000331062 for VSTM4 Gene via STRING

Gene Ontology (GO) - Biological Process for VSTM4 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for VSTM4 Gene

Drugs & Compounds for VSTM4 Gene

No Compound Related Data Available

Transcripts for VSTM4 Gene

Unigene Clusters for VSTM4 Gene

V-set and transmembrane domain containing 4:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for VSTM4

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for VSTM4 Gene

No ASD Table

Relevant External Links for VSTM4 Gene

GeneLoc Exon Structure for
VSTM4
ECgene alternative splicing isoforms for
VSTM4

Expression for VSTM4 Gene

mRNA expression in normal human tissues for VSTM4 Gene

mRNA differential expression in normal tissues according to GTEx for VSTM4 Gene

This gene is overexpressed in Adrenal Gland (x4.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for VSTM4 Gene



SOURCE GeneReport for Unigene cluster for VSTM4 Gene Hs.522928

genes like me logo Genes that share expression patterns with VSTM4: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for VSTM4 Gene

Orthologs for VSTM4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for VSTM4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia VSTM4 35
  • 88.82 (n)
  • 91.36 (a)
VSTM4 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia VSTM4 35
  • 85.42 (n)
  • 86.5 (a)
VSTM4 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Vstm4 35
  • 86.82 (n)
  • 88.7 (a)
Vstm4 16
Vstm4 36
  • 87 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia VSTM4 35
  • 98.75 (n)
  • 98.75 (a)
VSTM4 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Vstm4 35
  • 85.94 (n)
  • 87.04 (a)
oppossum
(Monodelphis domestica)
Mammalia VSTM4 36
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 57 (a)
OneToMany
-- 36
  • 80 (a)
OneToMany
chicken
(Gallus gallus)
Aves VSTM4 35
  • 68.67 (n)
  • 68 (a)
VSTM4 36
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia VSTM4 36
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia vstm4 35
  • 54.05 (n)
  • 48.57 (a)
zebrafish
(Danio rerio)
Actinopterygii vstm4b 35
  • 57.22 (n)
  • 49.49 (a)
vstm4a 36
  • 44 (a)
OneToMany
vstm4b 36
  • 43 (a)
OneToMany
Species with no ortholog for VSTM4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for VSTM4 Gene

ENSEMBL:
Gene Tree for VSTM4 (if available)
TreeFam:
Gene Tree for VSTM4 (if available)

Paralogs for VSTM4 Gene

No data available for Paralogs for VSTM4 Gene

Variants for VSTM4 Gene

Sequence variations from dbSNP and Humsavar for VSTM4 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs11754 -- 49,107,901(-) TCCCA(G/T)AAAAG reference, missense
rs13088 - 49,107,848(-) CTCCT(C/T)CGACT missense, reference
rs1055583 -- 49,018,289(-) TCTAG(A/C)AACTG utr-variant-3-prime
rs1125517 -- 49,035,494(+) GTCTC(C/T)CAAAA intron-variant
rs1877804 -- 49,024,838(+) AGGAA(C/T)AGATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for VSTM4 Gene

Variant ID Type Subtype PubMed ID
nsv7203 OTHER Inversion 18451855
nsv895365 CNV Loss 21882294
nsv895369 CNV Gain 21882294
nsv895371 CNV Gain 21882294
nsv831866 CNV Gain+Loss 17160897
nsv6620 CNV Loss 18451855
esv2736485 CNV Deletion 23290073
esv2845 CNV Deletion 18987735
esv6657 CNV Loss 19470904
nsv522731 CNV Loss 19592680
nsv895375 CNV Gain 21882294
esv21974 CNV Loss 19812545

Variation tolerance for VSTM4 Gene

Residual Variation Intolerance Score: 90.07% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.21; 76.08% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for VSTM4 Gene

HapMap Linkage Disequilibrium report
VSTM4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VSTM4 Gene

Disorders for VSTM4 Gene

Relevant External Links for VSTM4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
VSTM4
genes like me logo Genes that share disorders with VSTM4: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for VSTM4 Gene

Publications for VSTM4 Gene

  1. Genome-wide meta-analysis identifies new susceptibility loci for migraine. (PMID: 23793025) Anttila V. … . (Nat. Genet. 2013) 67
  2. A genome-wide association study of serum uric acid in African Americans. (PMID: 21294900) Charles B.A. … Rotimi C.N. (BMC Med Genomics 2011) 67
  3. Identification of the human testis protein phosphatase 1 interactome. (PMID: 21382349) Fardilha M. … da Cruz e Silva E.F. (Biochem. Pharmacol. 2011) 67
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 67
  5. The consensus coding sequences of human breast and colorectal cancers. (PMID: 16959974) Sjoeblom T. … Velculescu V.E. (Science 2006) 67

Products for VSTM4 Gene

Sources for VSTM4 Gene

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