Free for academic non-profit institutions. Other users need a Commercial license

Aliases for VSTM4 Gene

Aliases for VSTM4 Gene

  • V-Set And Transmembrane Domain Containing 4 2 3
  • C10orf72 3 4
  • V-Set And Transmembrane Domain-Containing Protein 4 3
  • Chromosome 10 Open Reading Frame 72 2

External Ids for VSTM4 Gene

Previous HGNC Symbols for VSTM4 Gene

  • C10orf72

Previous GeneCards Identifiers for VSTM4 Gene

  • GC10M050223

Summaries for VSTM4 Gene

GeneCards Summary for VSTM4 Gene

VSTM4 (V-Set And Transmembrane Domain Containing 4) is a Protein Coding gene.

UniProtKB/Swiss-Prot for VSTM4 Gene

  • Peptide Lv enhances L-type voltage-gated calcium channel (L-VGCC) currents in retinal photoreceptors.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VSTM4 Gene

Genomics for VSTM4 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for VSTM4 Gene

49,014,245 bp from pter
49,115,532 bp from pter
101,288 bases
Minus strand

Genomic View for VSTM4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for VSTM4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VSTM4 Gene

No data available for Regulatory Elements for VSTM4 Gene

Proteins for VSTM4 Gene

  • Protein details for VSTM4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    V-set and transmembrane domain-containing protein 4
    Protein Accession:
    Secondary Accessions:
    • B4DNI6
    • Q96MX7

    Protein attributes for VSTM4 Gene

    320 amino acids
    Molecular mass:
    36146 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for VSTM4 Gene


neXtProt entry for VSTM4 Gene

Proteomics data for VSTM4 Gene at MOPED

Post-translational modifications for VSTM4 Gene

  • Proteolytically cleaved to generate a bioactive peptide.
  • Glycosylation at Asn25, Asn41, Asn89, and Asn144
  • Modification sites at PhosphoSitePlus

Other Protein References for VSTM4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for VSTM4 Gene

Domains for VSTM4 Gene

Gene Families for VSTM4 Gene

Protein Domains for VSTM4 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 Ig-like (immunoglobulin-like) domain.
  • Contains 1 Ig-like (immunoglobulin-like) domain.
genes like me logo Genes that share domains with VSTM4: view

No data available for Suggested Antigen Peptide Sequences for VSTM4 Gene

Function for VSTM4 Gene

Molecular function for VSTM4 Gene

UniProtKB/Swiss-Prot Function:
Peptide Lv enhances L-type voltage-gated calcium channel (L-VGCC) currents in retinal photoreceptors.

Gene Ontology (GO) - Molecular Function for VSTM4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with VSTM4: view

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for VSTM4

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for VSTM4 Gene

Localization for VSTM4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for VSTM4 Gene

Peptide Lv: Secreted.
Cell membrane; Single-pass type I membrane protein.

Gene Ontology (GO) - Cellular Components for VSTM4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005886 plasma membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with VSTM4: view

No data available for Subcellular locations from COMPARTMENTS for VSTM4 Gene

Pathways for VSTM4 Gene

SuperPathways for VSTM4 Gene

No Data Available

Interacting Proteins for VSTM4 Gene

STRING Interaction Network Preview (showing 4 interactants - click image to see details)
Selected Interacting proteins: ENSP00000331062 for VSTM4 Gene via STRING

Gene Ontology (GO) - Biological Process for VSTM4 Gene


No data available for Pathways by source for VSTM4 Gene

Transcripts for VSTM4 Gene

Unigene Clusters for VSTM4 Gene

V-set and transmembrane domain containing 4:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for VSTM4

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for VSTM4 Gene

No ASD Table

Relevant External Links for VSTM4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for VSTM4 Gene

mRNA expression in normal human tissues for VSTM4 Gene

mRNA differential expression in normal tissues according to GTEx for VSTM4 Gene

This gene is overexpressed in Adrenal Gland (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for VSTM4 Gene

SOURCE GeneReport for Unigene cluster for VSTM4 Gene Hs.522928

genes like me logo Genes that share expressions with VSTM4: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Expression partners for VSTM4 Gene

Orthologs for VSTM4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for VSTM4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia VSTM4 35
  • 88.82 (n)
  • 91.36 (a)
VSTM4 36
  • 88 (a)
(Canis familiaris)
Mammalia VSTM4 35
  • 85.42 (n)
  • 86.5 (a)
VSTM4 36
  • 84 (a)
(Mus musculus)
Mammalia Vstm4 35
  • 86.82 (n)
  • 88.7 (a)
Vstm4 16
Vstm4 36
  • 87 (a)
(Pan troglodytes)
Mammalia VSTM4 35
  • 98.75 (n)
  • 98.75 (a)
VSTM4 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Vstm4 35
  • 85.94 (n)
  • 87.04 (a)
(Monodelphis domestica)
Mammalia VSTM4 36
  • 78 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 57 (a)
-- 36
  • 80 (a)
(Gallus gallus)
Aves VSTM4 35
  • 68.67 (n)
  • 68 (a)
VSTM4 36
  • 69 (a)
(Anolis carolinensis)
Reptilia VSTM4 36
  • 62 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia vstm4 35
  • 54.05 (n)
  • 48.57 (a)
(Danio rerio)
Actinopterygii vstm4b 35
  • 57.22 (n)
  • 49.49 (a)
vstm4a 36
  • 44 (a)
vstm4b 36
  • 43 (a)
Species with no ortholog for VSTM4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for VSTM4 Gene

Gene Tree for VSTM4 (if available)
Gene Tree for VSTM4 (if available)

Paralogs for VSTM4 Gene

No data available for Paralogs for VSTM4 Gene

Variants for VSTM4 Gene

Sequence variations from dbSNP and Humsavar for VSTM4 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs11754 -- 49,107,901(-) TCCCA(G/T)AAAAG reference, missense, nc-transcript-variant
rs13088 - 49,107,848(-) CTCCT(C/T)CGACT missense, reference, nc-transcript-variant
rs1055583 -- 49,018,289(-) TCTAG(A/C)AACTG utr-variant-3-prime, intron-variant
rs1125517 -- 49,035,494(+) GTCTC(C/T)CAAAA intron-variant
rs1877804 -- 49,024,838(+) AGGAA(C/T)AGATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for VSTM4 Gene

Variant ID Type Subtype PubMed ID
nsv7203 OTHER Inversion 18451855
nsv895365 CNV Loss 21882294
nsv895369 CNV Gain 21882294
nsv895371 CNV Gain 21882294
nsv831866 CNV Gain+Loss 17160897
nsv6620 CNV Loss 18451855
esv2736485 CNV Deletion 23290073
esv2845 CNV Deletion 18987735
esv6657 CNV Loss 19470904
nsv522731 CNV Loss 19592680
nsv895375 CNV Gain 21882294
esv21974 CNV Loss 19812545

Relevant External Links for VSTM4 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VSTM4 Gene

Disorders for VSTM4 Gene

No disorders were found for VSTM4 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for VSTM4 Gene

Publications for VSTM4 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  4. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A. … Goate A. (Am. J. Hum. Genet. 2006) 3
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3

Products for VSTM4 Gene

Sources for VSTM4 Gene

Back to Top