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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

VSTM4 Gene

protein-coding GIFtS: 39
GCID: GC10M050223

V-set and transmembrane domain containing 4

(Previous name: chromosome 10 open reading frame 72 )
(Previous symbol: C10orf72)

Explore 1 disease affiliated with
VSTM4 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
V-Set And Transmembrane Domain Containing 4¹ ²
C10orf72¹ ² ³
FLJ31737¹
Chromosome 10 Open Reading Frame 72¹
V-Set And Transmembrane Domain-Containing Protein 4²

External Ids:	HGNC: 26470¹	Entrez Gene: 196740²	Ensembl: ENSG00000165633⁷	UniProtKB: Q8IW00³

Export aliases for VSTM4 gene to outside databases

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000010.10 NC_018921.1 NT_030059.13

Regulatory elements:

Search SABiosciences Regulatory transcription factor binding sites for VSTM4
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search SABiosciences Chromatin IP Primers for VSTM4

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat VSTM4

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q11.23 Ensembl cytogenetic band: 10q11.23 HGNC cytogenetic band: 10q11.23

VSTM4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
VSTM4 gene location

GeneLoc information about chromosome 10 GeneLoc Exon Structure

GeneLoc location for GC10M050223: view genomic region (about GC identifiers)

Start:	50,222,333 bp from pter	End:	50,323,559 bp from pter
Size:	101,227 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: VSTM4_HUMAN, Q8IW00 (See protein sequence)

Recommended Name: V-set and transmembrane domain-containing protein 4 precursor

Size: 320 amino acids; 36146 Da

Subcellular location: Cell membrane; Single-pass type I membrane protein (Potential)

Secondary accessions: B4DNI6 Q96MX7

Alternative splicing: 2 isoforms: Q8IW00-1 Q8IW00-2

Explore the universe of human proteins at neXtProt for VSTM4: NX_Q8IW00

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q8IW00

VSTM4 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001026916.2 NP_659421.1

ENSEMBL proteins:

ENSP00000331062 ENSP00000298454

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	Uscn Proteins for VSTM4

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	IEA	--
GO:0016021	integral to membrane	IEA	--

VSTM4 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

VSTM4 for domains About GeneDecksing

4 InterPro domains/families:

IPR007110 Ig-like_dom

IPR003599 Ig_sub

IPR013783 Ig-like_fold

IPR013106 Ig_V-set

Graphical View of Domain Structure for InterPro Entry Q8IW00

ProtoNet protein and cluster: Q8IW00

UniProtKB/Swiss-Prot: VSTM4_HUMAN, Q8IW00

Similarity: Contains 1 Ig-like (immunoglobulin-like) domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for VSTM4

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

1 Interacting protein for VSTM4 (ENSP00000331062⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PPP1CC	ENSP00000335084⁴	STRING: ENSP00000335084

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for VSTM4
Search CenterWatch for drugs/clinical trials and news about VSTM4

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for VSTM4 gene (2 alternative transcripts):

NM_001031746.3 NM_144984.2

Unigene Cluster for VSTM4:

V-set and transmembrane domain containing 4

Hs.522928 [show with all ESTs]

Unigene Representative Sequence: NM_001031746

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000332853(uc001jhf.2) ENST00000476018 ENST00000298454(uc001jhh.2)

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		hsa-miR-323-3p hsa-miR-4291 hsa-miR-3607-3p hsa-miR-30d hsa-miR-30a hsa-miR-629* hsa-miR-761 hsa-miR-3688-3p

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Additional cDNA sequence:

AK001062.1 AK021993.1 AK056299.1 AK297931.1 AL080114.1 AL833529.1 BC017010.1 BC041414.1

6 DOTS entries:

DT.409201 DT.40107634 DT.95135114 DT.451893 DT.92418143 DT.40245291

24/110 AceView cDNA sequences (see all 110):

AL553283 NM_144984 AK056299 CR617276 AI127523 AI161256 AU137553 AI769171

AK001062 AL833529 AL080114 AW513534 BX119016 BQ184996 BF197544 AU119015

AI817799 BE645778 AI241338 BU632972 AW149603 BC017010 AA428491 CK905828

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

VSTM4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAGGTTTTCT

About this image

VSTM4 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 2 LifeMap Cells

Name

Category

PureStem™ progenitor EN7 (Embryonic Progenitor Cell)

PureStem™ progenitor Z1 (Embryonic Progenitor Cell)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See VSTM4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for VSTM4

SOURCE GeneReport for Unigene cluster: Hs.522928

SABiosciences Custom PCR Arrays for VSTM4

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for VSTM4 gene from 4/10 species (see all 10) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Vstm4^{1 , 5}	RIKEN cDNA E130203B14 gene⁵ V-set and transmembrane domain containing 4¹	86.65(n)¹ 88.33(a)¹		14 (19.40 cM)⁵ 320736¹ NM_178791.4¹ NP_848906.1¹ 32856756⁵
chicken (Gallus gallus)	Aves	VSTM4¹	V-set and transmembrane domain containing 4	68.97(n) 68.87(a)		423782 XM_421654.3 XP_421654.3
lizard (Anolis carolinensis)	Reptilia	VSTM4⁶	--	60(a)	1 ↔ 1	GL343297.1(716176-762041)
zebrafish (Danio rerio)	Actinopterygii	vstm4b¹	V-set and transmembrane domain containing 4b	57.05(n) 49.51(a)		100142652 XM_002664016.2 XP_002664062.2

ENSEMBL Gene Tree for VSTM4 (if available)
TreeFam Gene Tree for VSTM4 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 10 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs147650585^1,2		--	50221883(+)	`GAGGTC/TGCCAG`	1	--	ds500¹		0	--	--	--	--
rs115600036^1,2	F,	--	50221884(+)	`AGGTCG/ACCAGG`	1	--	ds500¹		1		WA	118
rs7897139^1,2	H	--	50221915(+)	`TCCTTA/TGTTTG`	1	--	ds500¹		4		NS EA	420
rs140587949^1,2		--	50221968(+)	`ACACTA/GGCTTA`	1	--	ds500¹		0	--	--	--	--
rs144479955^1,2		--	50222079(+)	`AAAAAC/TTCCTG`	1	--	ds500¹		0	--	--	--	--
rs11100973^1,2	H	--	50222106(+)	`CTGAGA/GTCCAT`	1	--	ds500¹		4		NS EA	420
rs147826455^1,2		--	50222143(+)	`AAGTGC/TACACA`	1	--	ds500¹		0	--	--	--	--
rs148864026^1,2		--	50222287(+)	`TGATGC/GAGGAC`	1	--	ds500¹		0	--	--	--	--
rs117914054^1,2		--	50222412(+)	`CTAAAT/ATGGAG`	1	--	ut3¹		1		NA	120
rs189818441^1,2		--	50222421(+)	`AGTGAC/TGCTAA`	1	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for VSTM4 (50222333 - 50323559 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for VSTM4: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

VSTM4 for disorders About GeneDecksing

1 disease for VSTM4: About MalaCards

alzheimer's disease

Export disorders for VSTM4 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for VSTM4 gene integrated from 9 sources:
(articles sorted by number of sources associating them with VSTM4)

Utopia: connect your pdf to the dynamic
world of online information

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
A genome-wide association study of serum uric acid in African Americans. (PubMed id 21294900)¹ Charles B.A....Rotimi C.N. (2011)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)¹ Rose J.E....Uhl G.R. (2010)
The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)² Sjoeblom T.... Velculescu V.E. (2006)
A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)¹ Grupe A....Goate A. (2006)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)¹ Kimura K.... Sugano S. (2006)
The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)² Deloukas P.... Rogers J. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 196740	HGNC: 26470	AceView: C10orf72	Ensembl:ENSG00000165633	euGenes: HUgn196740
ECgene: VSTM4	H-InvDB: VSTM4

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for VSTM4	Pharmacogenomics, SNPs, Pathways

Intellectual Property for VSTM4 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for VSTM4 gene:
Search GeneIP for patents involving VSTM4

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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About This Section


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GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes VSTM4 gene at Home site.

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VSTM4 Gene

V-set and transmembrane domain containing 4

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VSTM4 Gene

V-set and transmembrane domain containing 4

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