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Aliases for VSTM2B Gene

Aliases for VSTM2B Gene

  • V-Set And Transmembrane Domain Containing 2B 2 3

External Ids for VSTM2B Gene

Previous GeneCards Identifiers for VSTM2B Gene

  • GC19P034708
  • GC19P030017
  • GC19P026528

Summaries for VSTM2B Gene

GeneCards Summary for VSTM2B Gene

VSTM2B (V-Set And Transmembrane Domain Containing 2B) is a Protein Coding gene. An important paralog of this gene is VSTM2L.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VSTM2B Gene

Genomics for VSTM2B Gene

Regulatory Elements for VSTM2B Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for VSTM2B Gene

29,525,431 bp from pter
29,564,551 bp from pter
39,121 bases
Plus strand

Genomic View for VSTM2B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for VSTM2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VSTM2B Gene

Proteins for VSTM2B Gene

  • Protein details for VSTM2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    V-set and transmembrane domain-containing protein 2B
    Protein Accession:

    Protein attributes for VSTM2B Gene

    285 amino acids
    Molecular mass:
    30297 Da
    Quaternary structure:
    No Data Available

neXtProt entry for VSTM2B Gene

Proteomics data for VSTM2B Gene at MOPED

Post-translational modifications for VSTM2B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for VSTM2B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for VSTM2B Gene

Domains & Families for VSTM2B Gene

Gene Families for VSTM2B Gene

Protein Domains for VSTM2B Gene

Suggested Antigen Peptide Sequences for VSTM2B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
genes like me logo Genes that share domains with VSTM2B: view

Function for VSTM2B Gene

Gene Ontology (GO) - Molecular Function for VSTM2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with VSTM2B: view

Phenotypes for VSTM2B Gene

GenomeRNAi human phenotypes for VSTM2B:
genes like me logo Genes that share phenotypes with VSTM2B: view

Animal Model Products

miRNA for VSTM2B Gene

miRTarBase miRNAs that target VSTM2B

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for VSTM2B Gene

Localization for VSTM2B Gene

Subcellular locations from UniProtKB/Swiss-Prot for VSTM2B Gene

Membrane; Single-pass type I membrane protein.

Gene Ontology (GO) - Cellular Components for VSTM2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with VSTM2B: view

No data available for Subcellular locations from COMPARTMENTS for VSTM2B Gene

Pathways & Interactions for VSTM2B Gene

SuperPathways for VSTM2B Gene

No Data Available

Interacting Proteins for VSTM2B Gene

Gene Ontology (GO) - Biological Process for VSTM2B Gene


No data available for Pathways by source and SIGNOR curated interactions for VSTM2B Gene

Drugs & Compounds for VSTM2B Gene

No Compound Related Data Available

Transcripts for VSTM2B Gene

mRNA/cDNA for VSTM2B Gene

(6) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for VSTM2B Gene

V-set and transmembrane domain containing 2B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for VSTM2B Gene

No ASD Table

Relevant External Links for VSTM2B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for VSTM2B Gene

mRNA expression in normal human tissues for VSTM2B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for VSTM2B Gene

This gene is overexpressed in Brain - Anterior cingulate cortex (BA24) (x5.3), Brain - Amygdala (x4.6), Brain - Frontal Cortex (BA9) (x4.6), Brain - Putamen (basal ganglia) (x4.4), Brain - Nucleus accumbens (basal ganglia) (x4.3), Brain - Cortex (x4.2), and Brain - Substantia nigra (x4.2).

Protein differential expression in normal tissues from HIPED for VSTM2B Gene

This gene is overexpressed in Vitreous humor (49.1) and Pancreatic juice (19.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for VSTM2B Gene

SOURCE GeneReport for Unigene cluster for VSTM2B Gene Hs.451618

genes like me logo Genes that share expression patterns with VSTM2B: view

Protein tissue co-expression partners for VSTM2B Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for VSTM2B Gene

Orthologs for VSTM2B Gene

This gene was present in the common ancestor of chordates.

Orthologs for VSTM2B Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia VSTM2B 35
  • 87.89 (n)
  • 88.28 (a)
  • 83 (a)
(Mus musculus)
Mammalia Vstm2b 35
  • 84.21 (n)
  • 88.42 (a)
Vstm2b 16
Vstm2b 36
  • 85 (a)
(Pan troglodytes)
Mammalia VSTM2B 35
  • 98.67 (n)
  • 98.18 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Vstm2b 35
  • 83.86 (n)
  • 85.61 (a)
(Bos Taurus)
Mammalia VSTM2B 36
  • 79 (a)
(Monodelphis domestica)
Mammalia VSTM2B 36
  • 75 (a)
(Anolis carolinensis)
Reptilia VSTM2B 36
  • 55 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia vstm2b 35
  • 65.87 (n)
  • 66.4 (a)
(Danio rerio)
Actinopterygii zgc:194678 35
  • 60.25 (n)
  • 56.07 (a)
  • 55 (a)
Species with no ortholog for VSTM2B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for VSTM2B Gene

Gene Tree for VSTM2B (if available)
Gene Tree for VSTM2B (if available)

Paralogs for VSTM2B Gene

Paralogs for VSTM2B Gene

(2) SIMAP similar genes for VSTM2B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with VSTM2B: view

Variants for VSTM2B Gene

Sequence variations from dbSNP and Humsavar for VSTM2B Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs730427 -- 29,550,646(-) CACAC(C/T)GAGTA intron-variant
rs730428 -- 29,550,946(-) TCTCC(A/G)CTGGG intron-variant
rs734837 -- 29,550,119(+) AGCCA(A/C)GAAGC intron-variant
rs734838 -- 29,550,237(+) AAGAG(C/T)AGCCT intron-variant
rs734839 -- 29,550,338(+) GCTGA(A/G)GCAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for VSTM2B Gene

Variant ID Type Subtype PubMed ID
nsv833798 CNV Loss 17160897
esv21555 CNV Gain 19812545
esv275023 CNV Gain+Loss 21479260
nsv833799 CNV Gain 17160897

Variation tolerance for VSTM2B Gene

Gene Damage Index Score: 4.96; 68.07% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for VSTM2B Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VSTM2B Gene

Disorders for VSTM2B Gene

Relevant External Links for VSTM2B

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with VSTM2B: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for VSTM2B Gene

Publications for VSTM2B Gene

  1. Genetic variants associated with disordered eating. (PMID: 23568457) Wade T.D. … Martin N.G. (Int J Eat Disord 2013) 67
  2. Genome-wide meta-analysis for severe diabetic retinopathy. (PMID: 21441570) Grassi M.A. … Nicolae D.L. (Hum. Mol. Genet. 2011) 67
  3. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G. … Wijmenga C. (Gut 2009) 67
  4. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 67

Products for VSTM2B Gene

Sources for VSTM2B Gene

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