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Aliases for VSTM2B Gene

Aliases for VSTM2B Gene

  • V-Set And Transmembrane Domain Containing 2B 2 3

External Ids for VSTM2B Gene

Summaries for VSTM2B Gene

GeneCards Summary for VSTM2B Gene

VSTM2B (V-Set And Transmembrane Domain Containing 2B) is a Protein Coding gene. An important paralog of this gene is VSTM2L.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VSTM2B Gene

Genomics for VSTM2B Gene

Genomic Location for VSTM2B Gene

Start:
29,526,499 bp from pter
End:
29,564,551 bp from pter
Size:
38,053 bases
Orientation:
Plus strand

Genomic View for VSTM2B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for VSTM2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VSTM2B Gene

Regulatory Elements for VSTM2B Gene

Proteins for VSTM2B Gene

  • Protein details for VSTM2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NLU5-VTM2B_HUMAN
    Recommended name:
    V-set and transmembrane domain-containing protein 2B
    Protein Accession:
    A6NLU5
    Secondary Accessions:

    Protein attributes for VSTM2B Gene

    Size:
    285 amino acids
    Molecular mass:
    30297 Da
    Quaternary structure:
    No Data Available

neXtProt entry for VSTM2B Gene

Proteomics data for VSTM2B Gene at MOPED

Post-translational modifications for VSTM2B Gene

No Post-translational modifications

Other Protein References for VSTM2B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for VSTM2B Gene

Domains for VSTM2B Gene

Gene Families for VSTM2B Gene

HGNC:
  • VSET :Immunoglobulin superfamily / V-set domain containing

Protein Domains for VSTM2B Gene

UniProtKB/Swiss-Prot:

VTM2B_HUMAN
Domain:
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.:
    • A6NLU5
genes like me logo Genes that share domains with VSTM2B: view

Function for VSTM2B Gene

Gene Ontology (GO) - Molecular Function for VSTM2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with VSTM2B: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for VSTM2B Gene

Localization for VSTM2B Gene

Subcellular locations from UniProtKB/Swiss-Prot for VSTM2B Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for VSTM2B Gene COMPARTMENTS Subcellular localization image for VSTM2B gene
Compartment Confidence
extracellular 2
plasma membrane 2
endoplasmic reticulum 1
lysosome 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for VSTM2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with VSTM2B: view

Pathways for VSTM2B Gene

SuperPathways for VSTM2B Gene

No Data Available

Interacting Proteins for VSTM2B Gene

Gene Ontology (GO) - Biological Process for VSTM2B Gene

None

No data available for Pathways by source for VSTM2B Gene

Transcripts for VSTM2B Gene

mRNA/cDNA for VSTM2B Gene

(6) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for VSTM2B Gene

V-set and transmembrane domain containing 2B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for VSTM2B Gene

No ASD Table

Relevant External Links for VSTM2B Gene

GeneLoc Exon Structure for
VSTM2B
ECgene alternative splicing isoforms for
VSTM2B

Expression for VSTM2B Gene

mRNA expression in normal human tissues for VSTM2B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for VSTM2B Gene

This gene is overexpressed in Brain - Anterior cingulate cortex (BA24) (5.3), Brain - Amygdala (4.6), Brain - Frontal Cortex (BA9) (4.6), Brain - Putamen (basal ganglia) (4.4), Brain - Nucleus accumbens (basal ganglia) (4.3), Brain - Cortex (4.2), and Brain - Substantia nigra (4.2).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for VSTM2B Gene

SOURCE GeneReport for Unigene cluster for VSTM2B Gene Hs.451618

genes like me logo Genes that share expressions with VSTM2B: view

Orthologs for VSTM2B Gene

This gene was present in the common ancestor of chordates.

Orthologs for VSTM2B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia VSTM2B 36
  • 98.67 (n)
  • 98.18 (a)
VSTM2B 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia VSTM2B 37
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia VSTM2B 36
  • 87.89 (n)
  • 88.28 (a)
VSTM2B 37
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Vstm2b 36
  • 84.21 (n)
  • 88.42 (a)
Vstm2b 16
Vstm2b 37
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia VSTM2B 37
  • 75 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Vstm2b 36
  • 83.86 (n)
  • 85.61 (a)
lizard
(Anolis carolinensis)
Reptilia VSTM2B 37
  • 55 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia vstm2b 36
  • 65.87 (n)
  • 66.4 (a)
zebrafish
(Danio rerio)
Actinopterygii VSTM2B 37
  • 55 (a)
OneToOne
zgc:194678 36
  • 60.25 (n)
  • 56.07 (a)
Species with no ortholog for VSTM2B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for VSTM2B Gene

ENSEMBL:
Gene Tree for VSTM2B (if available)
TreeFam:
Gene Tree for VSTM2B (if available)

Paralogs for VSTM2B Gene

Paralogs for VSTM2B Gene

Selected SIMAP similar genes for VSTM2B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with VSTM2B: view

Variants for VSTM2B Gene

Sequence variations from dbSNP and Humsavar for VSTM2B Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs730427 -- 29,550,646(-) CACAC(C/T)GAGTA intron-variant
rs730428 -- 29,550,946(-) TCTCC(A/G)CTGGG intron-variant
rs734837 -- 29,550,119(+) AGCCA(A/C)GAAGC intron-variant
rs734838 -- 29,550,237(+) AAGAG(C/T)AGCCT intron-variant
rs734839 -- 29,550,338(+) GCTGA(A/G)GCAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for VSTM2B Gene

Variant ID Type Subtype PubMed ID
nsv833798 CNV Loss 17160897
esv21555 CNV Gain 19812545
esv275023 CNV Gain+Loss 21479260
nsv833799 CNV Gain 17160897

Relevant External Links for VSTM2B Gene

HapMap Linkage Disequilibrium report
VSTM2B

Disorders for VSTM2B Gene

Relevant External Links for VSTM2B

Genetic Association Database (GAD)
VSTM2B
Human Genome Epidemiology (HuGE) Navigator
VSTM2B
genes like me logo Genes that share disorders with VSTM2B: view

No data available for UniProtKB/Swiss-Prot for VSTM2B Gene

Publications for VSTM2B Gene

  1. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 3 4
  2. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G. … Wijmenga C. (Gut 2009) 3 49
  3. Genome-wide meta-analysis for severe diabetic retinopathy. (PMID: 21441570) Grassi M.A. … Nicolae D.L. (Hum. Mol. Genet. 2011) 3
  4. Genetic variants associated with disordered eating. (PMID: 23568457) Wade T.D. … Martin N.G. (Int J Eat Disord 2013) 3

Products for VSTM2B Gene

Sources for VSTM2B Gene

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