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Aliases for VSTM2A Gene

Aliases for VSTM2A Gene

  • V-Set And Transmembrane Domain Containing 2A 2 3 5
  • V-Set And Transmembrane Domain Containing 2 2 3
  • VSTM2 3 4
  • V-Set And Transmembrane Domain-Containing Protein 2A 3
  • Hypothetical Protein MGC33530 3

External Ids for VSTM2A Gene

Previous HGNC Symbols for VSTM2A Gene

  • VSTM2

Previous GeneCards Identifiers for VSTM2A Gene

  • GC07P054578
  • GC07P054447

Summaries for VSTM2A Gene

GeneCards Summary for VSTM2A Gene

VSTM2A (V-Set And Transmembrane Domain Containing 2A) is a Protein Coding gene. An important paralog of this gene is VSTM2B.

UniProtKB/Swiss-Prot for VSTM2A Gene

  • Plays a role in the regulation of the early stage of white and brown preadipocyte cell differentiation. Promotes adipogenic commitment of preadipocytes by increasing gene expression of the transcription factor PPARG in a BMP4-dependent signaling pathway.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VSTM2A Gene

Genomics for VSTM2A Gene

Regulatory Elements for VSTM2A Gene

Enhancers for VSTM2A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07G054291 0.5 ENCODE 6.8 -249.9 -249914 0.9 CTCF MAFK EP300 VSTM2A GC07M054232 LINC01445
GH07G054541 1 Ensembl ENCODE 0.7 +0.3 282 1.6 CTCF MXI1 SUZ12 RBBP5 POLR2A ZNF652 ZBTB20 EZH2 RNF2 REST VSTM2A VSTM2A-OT1
GH07G054544 1 Ensembl ENCODE 0.7 +3.6 3581 2.7 CTCF SUZ12 RBBP5 RAD21 GLIS2 EGR1 ZNF366 SMC3 PRDM10 ZBTB20 VSTM2A VSTM2A-OT1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around VSTM2A on UCSC Golden Path with GeneCards custom track

Genomic Location for VSTM2A Gene

Chromosome:
7
Start:
54,542,325 bp from pter
End:
54,571,080 bp from pter
Size:
28,756 bases
Orientation:
Plus strand

Genomic View for VSTM2A Gene

Genes around VSTM2A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
VSTM2A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for VSTM2A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VSTM2A Gene

Proteins for VSTM2A Gene

  • Protein details for VSTM2A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TAG5-VTM2A_HUMAN
    Recommended name:
    V-set and transmembrane domain-containing protein 2A
    Protein Accession:
    Q8TAG5
    Secondary Accessions:
    • A4D2E9
    • B5MC94

    Protein attributes for VSTM2A Gene

    Size:
    236 amino acids
    Molecular mass:
    25833 Da
    Quaternary structure:
    • Homodimer.
    SequenceCaution:
    • Sequence=AAH28404.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=EAL23809.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for VSTM2A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for VSTM2A Gene

Post-translational modifications for VSTM2A Gene

  • N-glycosylated. N-linked glycosylation is critical for secretion but not for preadipocyte cell differentiation activity.
  • Glycosylation at Asn35 and Asn175
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for VSTM2A Gene

Domains & Families for VSTM2A Gene

Gene Families for VSTM2A Gene

Protein Domains for VSTM2A Gene

Suggested Antigen Peptide Sequences for VSTM2A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with VSTM2A: view

No data available for UniProtKB/Swiss-Prot for VSTM2A Gene

Function for VSTM2A Gene

Molecular function for VSTM2A Gene

UniProtKB/Swiss-Prot Function:
Plays a role in the regulation of the early stage of white and brown preadipocyte cell differentiation. Promotes adipogenic commitment of preadipocytes by increasing gene expression of the transcription factor PPARG in a BMP4-dependent signaling pathway.

Gene Ontology (GO) - Molecular Function for VSTM2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042802 identical protein binding ISS --
genes like me logo Genes that share ontologies with VSTM2A: view
genes like me logo Genes that share phenotypes with VSTM2A: view

Animal Model Products

  • Taconic Biosciences Mouse Models for VSTM2A

CRISPR Products

miRNA for VSTM2A Gene

miRTarBase miRNAs that target VSTM2A

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for VSTM2A Gene

Localization for VSTM2A Gene

Subcellular locations from UniProtKB/Swiss-Prot for VSTM2A Gene

Secreted. Note=Secreted by adipose precursor cells (By similarity). Not detected in the nucleus (PubMed:28052263). {ECO:0000250 UniProtKB:Q8R0A6}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for VSTM2A gene
Compartment Confidence
extracellular 5
plasma membrane 4
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for VSTM2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region ISS --
GO:0005634 NOT nucleus IDA 28052263
GO:0005886 plasma membrane IBA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with VSTM2A: view

Pathways & Interactions for VSTM2A Gene

SuperPathways for VSTM2A Gene

No Data Available

Interacting Proteins for VSTM2A Gene

Gene Ontology (GO) - Biological Process for VSTM2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010628 positive regulation of gene expression IMP 28052263
GO:0010884 positive regulation of lipid storage IMP 28052263
GO:0030154 cell differentiation IEA --
GO:0070352 positive regulation of white fat cell proliferation IMP 28052263
GO:0071773 cellular response to BMP stimulus ISS --
genes like me logo Genes that share ontologies with VSTM2A: view

No data available for Pathways by source and SIGNOR curated interactions for VSTM2A Gene

Drugs & Compounds for VSTM2A Gene

No Compound Related Data Available

Transcripts for VSTM2A Gene

Unigene Clusters for VSTM2A Gene

V-set and transmembrane domain containing 2A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for VSTM2A Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c
SP1: - - -
SP2: - - -
SP3: - -
SP4: - -
SP5: -

Relevant External Links for VSTM2A Gene

GeneLoc Exon Structure for
VSTM2A
ECgene alternative splicing isoforms for
VSTM2A

Expression for VSTM2A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for VSTM2A Gene

mRNA differential expression in normal tissues according to GTEx for VSTM2A Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x9.3), Brain - Anterior cingulate cortex (BA24) (x7.1), Brain - Nucleus accumbens (basal ganglia) (x6.5), Brain - Cortex (x6.0), Brain - Hypothalamus (x5.2), Brain - Amygdala (x4.5), and Brain - Caudate (basal ganglia) (x4.2).

Protein differential expression in normal tissues from HIPED for VSTM2A Gene

This gene is overexpressed in Vitreous humor (34.5) and Cerebrospinal fluid (34.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for VSTM2A Gene



Protein tissue co-expression partners for VSTM2A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of VSTM2A Gene:

VSTM2A

SOURCE GeneReport for Unigene cluster for VSTM2A Gene:

Hs.335933

Evidence on tissue expression from TISSUES for VSTM2A Gene

  • Nervous system(4.8)
genes like me logo Genes that share expression patterns with VSTM2A: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for VSTM2A Gene

Orthologs for VSTM2A Gene

This gene was present in the common ancestor of chordates.

Orthologs for VSTM2A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia VSTM2A 34 35
  • 94.2 (n)
dog
(Canis familiaris)
Mammalia VSTM2A 34 35
  • 92.42 (n)
cow
(Bos Taurus)
Mammalia VSTM2A 34 35
  • 90.05 (n)
mouse
(Mus musculus)
Mammalia Vstm2a 34 16 35
  • 89.83 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia VSTM2A 35
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia VSTM2A 35
  • 79 (a)
OneToOne
chicken
(Gallus gallus)
Aves VSTM2A 34 35
  • 80.97 (n)
lizard
(Anolis carolinensis)
Reptilia VSTM2A 35
  • 74 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii zgc:110852 34
  • 62.85 (n)
VSTM2A (1 of 2) 35
  • 51 (a)
OneToMany
VSTM2A (2 of 2) 35
  • 46 (a)
OneToMany
Species where no ortholog for VSTM2A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for VSTM2A Gene

ENSEMBL:
Gene Tree for VSTM2A (if available)
TreeFam:
Gene Tree for VSTM2A (if available)

Paralogs for VSTM2A Gene

Paralogs for VSTM2A Gene

(2) SIMAP similar genes for VSTM2A Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with VSTM2A: view

Variants for VSTM2A Gene

Sequence variations from dbSNP and Humsavar for VSTM2A Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1000083370 -- 54,552,693(+) ATCAT(A/C)CATCT intron-variant
rs1000104547 -- 54,560,391(+) TGTGA(G/T)CTTGA intron-variant, utr-variant-3-prime
rs1000166177 -- 54,550,922(+) CCCGC(A/G)GCCGT intron-variant, utr-variant-3-prime
rs1000170733 -- 54,556,963(+) ATGAT(G/T)TCTGC intron-variant, upstream-variant-2KB, utr-variant-3-prime
rs1000221796 -- 54,569,667(+) TTGGA(A/T)TTTTC intron-variant, nc-transcript-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for VSTM2A Gene

Variant ID Type Subtype PubMed ID
esv2272226 CNV deletion 18987734
esv2734425 CNV deletion 23290073
nsv1024361 CNV gain 25217958
nsv475524 CNV novel sequence insertion 20440878
nsv950218 CNV deletion 24416366

Variation tolerance for VSTM2A Gene

Residual Variation Intolerance Score: 55.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.64; 45.59% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for VSTM2A Gene

Human Gene Mutation Database (HGMD)
VSTM2A
SNPedia medical, phenotypic, and genealogical associations of SNPs for
VSTM2A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VSTM2A Gene

Disorders for VSTM2A Gene

Relevant External Links for VSTM2A

Genetic Association Database (GAD)
VSTM2A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
VSTM2A

No disorders were found for VSTM2A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for VSTM2A Gene

Publications for VSTM2A Gene

  1. Amplification of adipogenic commitment by VSTM2A. (PMID: 28052263) Secco B. … Laplante M. (Cell Rep. 2017) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 3 4 64
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for VSTM2A Gene

Sources for VSTM2A Gene

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