Free for academic non-profit institutions. Other users need a Commercial license

Aliases for VSTM1 Gene

Aliases for VSTM1 Gene

  • V-Set And Transmembrane Domain Containing 1 2 3 5
  • Signal Inhibitory Receptor On Leukocytes-1 3 4
  • SIRL-1 3 4
  • OSCAR-Like Transcript-1 3
  • LAIR Homolog 3
  • UNQ3033 3
  • SIRL1 3

External Ids for VSTM1 Gene

Previous GeneCards Identifiers for VSTM1 Gene

  • GC19M059236
  • GC19M054544
  • GC19M050859

Summaries for VSTM1 Gene

GeneCards Summary for VSTM1 Gene

VSTM1 (V-Set And Transmembrane Domain Containing 1) is a Protein Coding gene. GO annotations related to this gene include cytokine activity.

UniProtKB/Swiss-Prot for VSTM1 Gene

  • Isoform 2: Behaves as a cytokine, promoting IL17A secretion by CD4+ T-cells, and differentiation and activation of IL17 producing helper T-cells (TH17).

  • Isoform 1: Inhibitory immune receptor involved in the regulation of phagocytes.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VSTM1 Gene

Genomics for VSTM1 Gene

Regulatory Elements for VSTM1 Gene

Enhancers for VSTM1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around VSTM1 on UCSC Golden Path with GeneCards custom track

Promoters for VSTM1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around VSTM1 on UCSC Golden Path with GeneCards custom track

Genomic Location for VSTM1 Gene

Chromosome:
19
Start:
54,040,825 bp from pter
End:
54,063,966 bp from pter
Size:
23,142 bases
Orientation:
Minus strand

Genomic View for VSTM1 Gene

Genes around VSTM1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
VSTM1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for VSTM1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VSTM1 Gene

Proteins for VSTM1 Gene

  • Protein details for VSTM1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UX27-VSTM1_HUMAN
    Recommended name:
    V-set and transmembrane domain-containing protein 1
    Protein Accession:
    Q6UX27
    Secondary Accessions:
    • B6A8C6
    • D2DJS3
    • D2DJS4
    • Q496B6
    • Q496B7

    Protein attributes for VSTM1 Gene

    Size:
    236 amino acids
    Molecular mass:
    26109 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for VSTM1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for VSTM1 Gene

Proteomics data for VSTM1 Gene at MOPED

Post-translational modifications for VSTM1 Gene

No data available for DME Specific Peptides for VSTM1 Gene

Domains & Families for VSTM1 Gene

Gene Families for VSTM1 Gene

Protein Domains for VSTM1 Gene

Graphical View of Domain Structure for InterPro Entry

Q6UX27

UniProtKB/Swiss-Prot:

VSTM1_HUMAN :
  • Contains 2 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases. Both motives are required for full inhibition of FCER1A-mediated degranulation.
Domain:
  • Contains 2 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases. Both motives are required for full inhibition of FCER1A-mediated degranulation.
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
genes like me logo Genes that share domains with VSTM1: view

Function for VSTM1 Gene

Molecular function for VSTM1 Gene

UniProtKB/Swiss-Prot Function:
Isoform 2: Behaves as a cytokine, promoting IL17A secretion by CD4+ T-cells, and differentiation and activation of IL17 producing helper T-cells (TH17).
UniProtKB/Swiss-Prot Function:
Isoform 1: Inhibitory immune receptor involved in the regulation of phagocytes.

Gene Ontology (GO) - Molecular Function for VSTM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with VSTM1: view
genes like me logo Genes that share phenotypes with VSTM1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for VSTM1 Gene

Localization for VSTM1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for VSTM1 Gene

Isoform 1: Membrane; Single-pass membrane protein.
Isoform 2: Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for VSTM1 Gene COMPARTMENTS Subcellular localization image for VSTM1 gene
Compartment Confidence
extracellular 3
plasma membrane 3
endoplasmic reticulum 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for VSTM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with VSTM1: view

Pathways & Interactions for VSTM1 Gene

SuperPathways for VSTM1 Gene

No Data Available

Interacting Proteins for VSTM1 Gene

Gene Ontology (GO) - Biological Process for VSTM1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for VSTM1 Gene

Drugs & Compounds for VSTM1 Gene

No Compound Related Data Available

Transcripts for VSTM1 Gene

Unigene Clusters for VSTM1 Gene

V-set and transmembrane domain containing 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for VSTM1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5
SP1:
SP2: -

Relevant External Links for VSTM1 Gene

GeneLoc Exon Structure for
VSTM1
ECgene alternative splicing isoforms for
VSTM1

Expression for VSTM1 Gene

mRNA expression in normal human tissues for VSTM1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for VSTM1 Gene

This gene is overexpressed in Whole Blood (x42.3) and Pituitary (x4.3).

Protein differential expression in normal tissues from HIPED for VSTM1 Gene

This gene is overexpressed in Monocytes (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for VSTM1 Gene



SOURCE GeneReport for Unigene cluster for VSTM1 Gene Hs.444431

mRNA Expression by UniProt/SwissProt for VSTM1 Gene

Q6UX27-VSTM1_HUMAN
Tissue specificity: Expressed on myeloid (neutrophils, eosinophils and monocytes) but not on lymphoid cells.
genes like me logo Genes that share expression patterns with VSTM1: view

Protein tissue co-expression partners for VSTM1 Gene

- Elite partner

Primer Products

Orthologs for VSTM1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for VSTM1 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia VSTM1 35
  • 78.12 (n)
  • 65.13 (a)
VSTM1 36
  • 64 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia VSTM1 35
  • 99.09 (n)
  • 98.18 (a)
VSTM1 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC100360054 35
  • 67.93 (n)
  • 51.63 (a)
cow
(Bos Taurus)
Mammalia VSTM1 36
  • 45 (a)
OneToOne
Species with no ortholog for VSTM1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for VSTM1 Gene

ENSEMBL:
Gene Tree for VSTM1 (if available)
TreeFam:
Gene Tree for VSTM1 (if available)

Paralogs for VSTM1 Gene

genes like me logo Genes that share paralogs with VSTM1: view

No data available for Paralogs for VSTM1 Gene

Variants for VSTM1 Gene

Sequence variations from dbSNP and Humsavar for VSTM1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
VAR_030034 -

Structural Variations from Database of Genomic Variants (DGV) for VSTM1 Gene

Variant ID Type Subtype PubMed ID
esv2718812 CNV Deletion 23290073
nsv833877 CNV Loss 17160897
nsv458782 CNV Gain 19166990
nsv510773 CNV Loss 20534489
nsv820269 CNV Gain 19587683
nsv9750 CNV Gain 18304495
nsv435707 CNV Deletion 17901297
nsv182 CNV Loss 15895083
nsv2542 CNV Loss 18451855
esv2552009 CNV Deletion 19546169
dgv663e199 CNV Deletion 23128226
nsv828625 CNV Loss 20364138
nsv820902 CNV Deletion 20802225
esv2718849 CNV Deletion 23290073
nsv498905 CNV Loss 21111241
esv27833 CNV Gain 19812545
esv987659 CNV Gain 20482838
esv2595621 CNV Loss 19546169
nsv819771 CNV Gain 19587683
esv995580 CNV Gain 20482838

Variation tolerance for VSTM1 Gene

Residual Variation Intolerance Score: 50.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.64; 78.35% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for VSTM1 Gene

Disorders for VSTM1 Gene

Relevant External Links for VSTM1

Genetic Association Database (GAD)
VSTM1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
VSTM1

No disorders were found for VSTM1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for VSTM1 Gene

Publications for VSTM1 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 3 4 67
  2. VSTM-v1, a potential myeloid differentiation antigen that is downregulated in bone marrow cells from myeloid leukemia patients. (PMID: 25887911) Xie M. … Ruan G. (J Hematol Oncol 2015) 3
  3. Signal inhibitory receptor on leukocytes-1 (SIRL-1) negatively regulates the oxidative burst in human phagocytes. (PMID: 23436183) Steevels T.A. … Meyaard L. (Eur. J. Immunol. 2013) 3
  4. Ligation of signal inhibitory receptor on leukocytes-1 suppresses the release of neutrophil extracellular traps in systemic lupus erythematosus. (PMID: 24205237) Van Avondt K. … Meyaard L. (PLoS ONE 2013) 3
  5. Signal inhibitory receptor on leukocytes-1 is a novel functional inhibitory immune receptor expressed on human phagocytes. (PMID: 20375307) Steevels T.A. … Meyaard L. (J. Immunol. 2010) 3

Products for VSTM1 Gene

Sources for VSTM1 Gene

Content