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Aliases for VSNL1 Gene

Aliases for VSNL1 Gene

  • Visinin Like 1 2 3 5
  • Hippocalcin-Like Protein 3 2 3 4
  • VILIP 3 4
  • VLP-1 3 4
  • HLP3 3 4
  • Visinin-Like 1 3
  • HUVISL1 3
  • VILIP-1 3
  • HPCAL3 3
  • VISL1 4

External Ids for VSNL1 Gene

Previous GeneCards Identifiers for VSNL1 Gene

  • GC02P017607
  • GC02P017706
  • GC02P017643
  • GC02P017496
  • GC02P017720

Summaries for VSNL1 Gene

Entrez Gene Summary for VSNL1 Gene

  • This gene is a member of the visinin/recoverin subfamily of neuronal calcium sensor proteins. The encoded protein is strongly expressed in granule cells of the cerebellum where it associates with membranes in a calcium-dependent manner and modulates intracellular signaling pathways of the central nervous system by directly or indirectly regulating the activity of adenylyl cyclase. Alternatively spliced transcript variants have been observed, but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for VSNL1 Gene

VSNL1 (Visinin Like 1) is a Protein Coding gene. Diseases associated with VSNL1 include Acute Encephalopathy With Biphasic Seizures And Late Reduced Diffusion and Alzheimer Disease. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is KCNIP3.

UniProtKB/Swiss-Prot for VSNL1 Gene

  • Regulates (in vitro) the inhibition of rhodopsin phosphorylation in a calcium-dependent manner.

Gene Wiki entry for VSNL1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VSNL1 Gene

Genomics for VSNL1 Gene

Regulatory Elements for VSNL1 Gene

Enhancers for VSNL1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around VSNL1 on UCSC Golden Path with GeneCards custom track

Promoters for VSNL1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around VSNL1 on UCSC Golden Path with GeneCards custom track

Genomic Location for VSNL1 Gene

17,539,126 bp from pter
17,657,018 bp from pter
117,893 bases
Plus strand

Genomic View for VSNL1 Gene

Genes around VSNL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
VSNL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for VSNL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VSNL1 Gene

Proteins for VSNL1 Gene

  • Protein details for VSNL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Visinin-like protein 1
    Protein Accession:
    Secondary Accessions:
    • D6W515
    • P28677
    • P29103
    • P42323
    • Q9UM20

    Protein attributes for VSNL1 Gene

    191 amino acids
    Molecular mass:
    22142 Da
    Quaternary structure:
    No Data Available
    • Probably binds three calcium ions.

neXtProt entry for VSNL1 Gene

Proteomics data for VSNL1 Gene at MOPED

Post-translational modifications for VSNL1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for VSNL1 Gene

Antibody Products

No data available for DME Specific Peptides for VSNL1 Gene

Domains & Families for VSNL1 Gene

Gene Families for VSNL1 Gene

Protein Domains for VSNL1 Gene

Suggested Antigen Peptide Sequences for VSNL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 4 EF-hand domains.
  • Belongs to the recoverin family.
  • Contains 4 EF-hand domains.
  • Belongs to the recoverin family.
genes like me logo Genes that share domains with VSNL1: view

Function for VSNL1 Gene

Molecular function for VSNL1 Gene

GENATLAS Biochemistry:
visinin-like peptide 1,homolog to Rat RNVP1
UniProtKB/Swiss-Prot Function:
Regulates (in vitro) the inhibition of rhodopsin phosphorylation in a calcium-dependent manner.

Phenotypes for VSNL1 Gene

genes like me logo Genes that share phenotypes with VSNL1: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for VSNL1 Gene

Localization for VSNL1 Gene

Subcellular locations from

Jensen Localization Image for VSNL1 Gene COMPARTMENTS Subcellular localization image for VSNL1 gene
Compartment Confidence
cytosol 4
peroxisome 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for VSNL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IEA --
genes like me logo Genes that share ontologies with VSNL1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for VSNL1 Gene

Pathways & Interactions for VSNL1 Gene

SuperPathways for VSNL1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for VSNL1 Gene


No data available for Pathways by source and SIGNOR curated interactions for VSNL1 Gene

Drugs & Compounds for VSNL1 Gene

(1) Drugs for VSNL1 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
genes like me logo Genes that share compounds with VSNL1: view

Transcripts for VSNL1 Gene

Unigene Clusters for VSNL1 Gene

Visinin-like 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for VSNL1 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5
SP2: - -

Relevant External Links for VSNL1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for VSNL1 Gene

mRNA expression in normal human tissues for VSNL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for VSNL1 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x11.7), Brain - Anterior cingulate cortex (BA24) (x9.1), Brain - Cortex (x7.3), and Brain - Cerebellar Hemisphere (x5.5).

Protein differential expression in normal tissues from HIPED for VSNL1 Gene

This gene is overexpressed in Frontal cortex (35.5) and Brain (19.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for VSNL1 Gene

SOURCE GeneReport for Unigene cluster for VSNL1 Gene Hs.444212

mRNA Expression by UniProt/SwissProt for VSNL1 Gene

Tissue specificity: Brain and retina. Neuron-specific in the central and peripheral nervous system. Increased in the cerebrospinal fluid of Alzheimer disease patients (at protein level).
genes like me logo Genes that share expression patterns with VSNL1: view

Primer Products

No data available for Protein tissue co-expression partners for VSNL1 Gene

Orthologs for VSNL1 Gene

This gene was present in the common ancestor of animals.

Orthologs for VSNL1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia VSNL1 35
  • 94.76 (n)
  • 100 (a)
VSNL1 36
  • 100 (a)
(Mus musculus)
Mammalia Vsnl1 35
  • 91.8 (n)
  • 100 (a)
Vsnl1 16
Vsnl1 36
  • 100 (a)
(Pan troglodytes)
Mammalia VSNL1 35
  • 99.13 (n)
  • 100 (a)
VSNL1 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Vsnl1 35
  • 91.97 (n)
  • 99.48 (a)
(Monodelphis domestica)
Mammalia VSNL1 36
  • 100 (a)
(Ornithorhynchus anatinus)
Mammalia VSNL1 36
  • 91 (a)
(Gallus gallus)
Aves VSNL1 35
  • 89.18 (n)
  • 100 (a)
VSNL1 36
  • 100 (a)
(Anolis carolinensis)
Reptilia VSNL1 36
  • 84 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia vsnl1 35
  • 85.17 (n)
  • 99.48 (a)
(Danio rerio)
Actinopterygii vsnl1b 35
  • 83.77 (n)
  • 96.86 (a)
vsnl1a 36
  • 96 (a)
vsnl1b 36
  • 97 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.335 35
fruit fly
(Drosophila melanogaster)
Insecta CG7646 37
  • 45 (a)
Nca 37
  • 71 (a)
Nca 36
  • 71 (a)
(Caenorhabditis elegans)
Secernentea ncs-2 37
  • 45 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 64 (a)
Species with no ortholog for VSNL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for VSNL1 Gene

Gene Tree for VSNL1 (if available)
Gene Tree for VSNL1 (if available)

Paralogs for VSNL1 Gene

genes like me logo Genes that share paralogs with VSNL1: view

Variants for VSNL1 Gene

Sequence variations from dbSNP and Humsavar for VSNL1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1042674 - 17,649,441(+) GTTTG(C/G)CCAGC reference, missense
rs1042685 - 17,655,333(+) ATTCA(A/G)AGAAG reference, missense
rs391399 -- 17,560,233(-) TTGTG(G/T)CATTA intron-variant
rs405303 -- 17,559,420(+) AAAAA(A/C)AACAA intron-variant
rs405783 -- 17,565,840(-) attca(A/G)ttaag intron-variant

Structural Variations from Database of Genomic Variants (DGV) for VSNL1 Gene

Variant ID Type Subtype PubMed ID
esv2719748 CNV Deletion 23290073

Variation tolerance for VSNL1 Gene

Residual Variation Intolerance Score: 42% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.09; 2.10% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for VSNL1 Gene

Disorders for VSNL1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for VSNL1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
acute encephalopathy with biphasic seizures and late reduced diffusion
  • aesd
alzheimer disease
  • alzheimer disease, late-onset
- elite association - COSMIC cancer census association via MalaCards
Search VSNL1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for VSNL1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with VSNL1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for VSNL1 Gene

Publications for VSNL1 Gene

  1. Sequence characterization and genetic mapping of the human VSNL1 gene, a homologue of the rat visinin-like peptide RNVP1. (PMID: 8530085) Polymeropoulos M.H. … Lennon G.G. (Genomics 1995) 2 3 4 23 67
  2. Visinin-like protein 1 regulates natriuretic peptide receptor B in the heart. (PMID: 20079378) Buttgereit J. … Bader M. (Regul. Pept. 2010) 3 23
  3. Involvement of visinin-like protein-1 (VSNL-1) in regulating proliferative and invasive properties of neuroblastoma. (PMID: 17615261) Xie Y. … Ren Y. (Carcinogenesis 2007) 3 23
  4. Functional contribution of Ca2+ and Mg2+ to the intermolecular interaction of visinin-like proteins. (PMID: 16703469) Jheng F.F. … Chang L.S. (Protein J. 2006) 3 23
  5. Hippocampal expression of the calcium sensor protein visinin-like protein-1 in schizophrenia. (PMID: 11930147) Bernstein H.G. … Bogerts B. (Neuroreport 2002) 3 23

Products for VSNL1 Gene

Sources for VSNL1 Gene