VSNL1 Gene

Aliases
for VSNL1 gene

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Previous GC identifers: GC02P017607 GC02P017706 GC02P017643 GC02P017496

Summaries
for VSNL1 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Genomic Views
for VSNL1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000002.11  NC_018913.2  NT_022184.16  

SwitchGear Promoter luciferase reporter plasmid: VSNL1 promoter sequence

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat VSNL1

VSNL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P017720:  view genomic region     (about GC identifiers)

Proteins
for VSNL1 gene

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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Explore the universe of human proteins at neXtProt for VSNL1: NX_P62760

Explore proteomics data for VSNL1 at MOPED

Post-translational modifications: 

VSNL1 Human Recombinant Protein Products:

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	antibodies-online peptides for VSNL1

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VSNL1 Assay Products:

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	antibodies-online kits for VSNL1 (11 products)

Domains /
Families
for VSNL1 gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
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ProtoNet protein and cluster: P62760

Find genes that share domains with VSNL1           About GenesLikeMe

Function
for VSNL1 gene

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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     Gene Ontology (GO): 1 molecular function term:    About this table

genOway: Develop your customized and physiologically relevant rodent model for VSNL1

miRNA Products:		miRTarBase miRNAs that target VSNL1: hsa-mir-181b-5p (MIRT003036)
		Block miRNA regulation of human, mouse, rat VSNL1 using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate VSNL1 (see all 30):
		hsa-miR-217 hsa-miR-3910 hsa-miR-607 hsa-let-7d hsa-miR-202 hsa-let-7c hsa-miR-4298 hsa-let-7g
		SwitchGear 3'UTR luciferase reporter plasmid: VSNL1 3' UTR sequence

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		Predesigned siRNA for gene silencing in human, mouse, rat VSNL1

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for VSNL1

Clone Products:		OriGene clones in human, mouse for VSNL1 (see all 7) OriGene ORF clones in mouse, rat for VSNL1 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: VSNL1 (NM_003385)
		Sino Biological Human cDNA Clone for VSNL1
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for VSNL1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VSNL1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for VSNL1
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In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VSNL1

Localization
for VSNL1 gene

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Pathways & Interactions
for VSNL1 gene

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Drugs & Compounds
for VSNL1 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
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Transcripts
for VSNL1 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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Expression
for VSNL1 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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VSNL1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: TGAAAAGTAA

About this image

Brain (Nervous System)    fully expand to see all 15 entries
Thalamus
Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 5 entries
hIPS1
Skeletal Muscle (Muscoskeletal System)    fully expand to see all 4 entries
Muscle Progenitor Cells Mandibular Arch Muscles
Kidney (Urinary System)    fully expand to see all 3 entries
Ureteric Bud Tip Cells Ureteric Bud
Ureteric Bud
Lung (Respiratory System)
Basal Cells Trachea

Primer Products:		OriGene qPCR primer pairs and template standards for VSNL1 OriGene qSTAR qPCR primer pairs in human, mouse for VSNL1
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		QuantiFast Probe-based Assays in human, mouse, rat VSNL1

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VSNL1

Orthologs
for VSNL1 gene

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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Paralogs
for VSNL1 gene

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
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Paralogs for VSNL1 gene

HPCA²  KCNIP3²  KCNIP4²  KCNIP1²  GUCA1A²  RCVRN²  HPCAL1²  GUCA1B²  

NCALD²  KCNIP2²  HPCAL4²  NCS1²  GUCA1C²  

Selected SIMAP similar genes for VSNL1 using alignment to 5 protein entries:     VISL1_HUMAN (see all proteins) (see all similar genes):

HPCAL4    NCALD    DKFZp781K1922    HPCAL1    HPCA    NCS1

RCVRN    GUCA1A_C250T    KCNIP1    KCNIP4    KCNIP3    KCNIP2

GUCA1B    GUCA1A_T320C    DKFZp686E1183    GUCA1A    EFCAB1    GUCA1C

Find genes that share paralogs with VSNL1           About GenesLikeMe

Genomic Variants
for VSNL1 gene

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for VSNL1 (see all 2109)    About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs789936621,2	C,F	--	17719841(+)	ACATTT/ATTTCC	1	--	us2k1		1		WA	118
rs1439645131,2		--	17719923(+)	TAGGTA/GTATCT	1	--	us2k1		0	--	--	--	--
rs1897896931,2		--	17719997(+)	TTCTCC/GAGAGA	1	--	us2k1		0	--	--	--	--
rs1812931441,2		--	17720043(+)	GAAATA/CGACCA	1	--	us2k1		0	--	--	--	--
rs130061721,2	C,F	--	17720203(+)	CCAGAG/ACGAAG	1	--	us2k1		3		NA WA	240
rs795016331,2	C,F	--	17720270(+)	GCGCCG/CTGGTC	1	--	us2k1		1		NA	120
rs621304411,2	C,F	--	17720430(+)	AGTTCC/ATGGGT	1	--	us2k1		2		NA	122
rs75938811,2	C,F,A,H	--	17720520(+)	GACTTG/CTCTGG	1	--	us2k1 ese3		6		NS EA NA	538
rs762609171,2	C,F	--	17720675(+)	GGTAGG/ATCAAC	1	--	us2k1		1		WA	118
rs1850759951,2		--	17720722(+)	ACGCTC/GTGCAA	1	--	us2k1		0	--	--	--	--

HapMap Linkage Disequilibrium report for VSNL1 (17720393 - 17838285 bp)

Structural Variations
     Database of Genomic Variants (DGV) 1 variation for VSNL1:    About this table    

Variant ID	Type	Subtype	PubMed ID
esv2719748	CNV	Deletion	23290073

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing VSNL1

DNA2.0 Custom Variant and Variant Library Synthesis for VSNL1

Disorders / Diseases
for VSNL1 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
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1 Novoseek inferred disease relationship for VSNL1 gene    About this table

Publications
for VSNL1 gene

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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1. Sequence characterization and genetic mapping of the human VSNL1 gene, a homologue of the rat visinin-like peptide RNVP1. (PubMed id 8530085)^{1, 2, 3, 9} Polymeropoulos M.H.... Lennon G.G. (Genomics 1995)
2. Isolation of two human cDNAs, HLP3 and HLP4, homologous to the neuron-specific calcium-binding protein genes. (PubMed id 10520747)^{1, 2, 9} Kobayashi M.... Takamatsu K. (DNA Seq. 1998)
3. Genome-wide association study of Alzheimer's disease with psychotic symptoms. (PubMed id 22005930)^{1, 4} Hollingworth P....Williams J. (Mol. Psychiatry 2012)
4. MicroRNAs and target site screening reveals a pre-microRNA-30e variant associated with schizophrenia. (PubMed id 20347265)^{1, 4} Xu Y....Liu P. (Schizophr. Res. 2010)
5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
6. Electron microscopic localization of gamma- and beta II-subspecies of protein kinase C in rat hippocampus. (PubMed id 2202488)^{1, 3} Kose A....Tanaka C. (Brain Res. 1990)
7. Involvement of visinin-like protein-1 (VSNL-1) in regulating proliferative and invasive properties of neuroblastoma. (PubMed id 17615261)^{1, 9} Xie Y....Ren Y. (Carcinogenesis 2007)
8. The neuronal calcium-sensor protein VILIP modulates cyclic AMP accumulation in stably transfected C6 glioma cells: amino-terminal myristoylation determines functional activity. (PubMed id 9109541)^{1, 9} Braunewell K.H....Gundelfinger E.D. (J. Neurochem. 1997)
9. The neuronal EF-hand Ca(2+)-binding protein VILIP: interaction with cell membrane and actin-based cytoskeleton. (PubMed id 8780737)^{1, 9} Lenz S.E....Gundelfinger E.D. (Biochem. Biophys. Res. Commun. 1996)
10. Visinin-like protein 1 regulates natriuretic peptide receptor B in the heart. (PubMed id 20079378)^{1, 9} Buttgereit J....Bader M. (Regul. Pept. 2010)

External Searches for VSNL1 gene

Genome Databases showing VSNL1 gene

Other Databases showing VSNL1 gene

Specialized Databases showing VSNL1 gene

Products
for VSNL1 gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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