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Aliases for VSIG8 Gene

Aliases for VSIG8 Gene

  • V-Set And Immunoglobulin Domain Containing 8 2 3 5
  • C1orf204 4

External Ids for VSIG8 Gene

Previous GeneCards Identifiers for VSIG8 Gene

  • GC01M156638
  • GC01M158070
  • GC01M159824
  • GC01M131180

Summaries for VSIG8 Gene

GeneCards Summary for VSIG8 Gene

VSIG8 (V-Set And Immunoglobulin Domain Containing 8) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding. An important paralog of this gene is CXADR.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VSIG8 Gene

Genomics for VSIG8 Gene

Regulatory Elements for VSIG8 Gene

Enhancers for VSIG8 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around VSIG8 on UCSC Golden Path with GeneCards custom track

Genomic Location for VSIG8 Gene

159,854,316 bp from pter
159,862,657 bp from pter
8,342 bases
Minus strand

Genomic View for VSIG8 Gene

Genes around VSIG8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
VSIG8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for VSIG8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VSIG8 Gene

Proteins for VSIG8 Gene

  • Protein details for VSIG8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    V-set and immunoglobulin domain-containing protein 8
    Protein Accession:
    Secondary Accessions:
    • Q5VU14

    Protein attributes for VSIG8 Gene

    414 amino acids
    Molecular mass:
    43891 Da
    Quaternary structure:
    No Data Available
    • Sequence=AK096506; Type=Erroneous termination; Positions=409; Note=Translated as Lys.; Evidence={ECO:0000305};

    Alternative splice isoforms for VSIG8 Gene


neXtProt entry for VSIG8 Gene

Proteomics data for VSIG8 Gene at MOPED

Post-translational modifications for VSIG8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for VSIG8 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for VSIG8 Gene

Domains & Families for VSIG8 Gene

Gene Families for VSIG8 Gene

Protein Domains for VSIG8 Gene

Suggested Antigen Peptide Sequences for VSIG8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 2 Ig-like V-type (immunoglobulin-like) domains.
  • Contains 2 Ig-like V-type (immunoglobulin-like) domains.
genes like me logo Genes that share domains with VSIG8: view

Function for VSIG8 Gene

genes like me logo Genes that share phenotypes with VSIG8: view

Animal Models for VSIG8 Gene

MGI Knock Outs for VSIG8:

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for VSIG8 Gene

Localization for VSIG8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for VSIG8 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for VSIG8 Gene COMPARTMENTS Subcellular localization image for VSIG8 gene
Compartment Confidence
plasma membrane 3
extracellular 2
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for VSIG8 Gene

Pathways & Interactions for VSIG8 Gene

SuperPathways for VSIG8 Gene

No Data Available

Interacting Proteins for VSIG8 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
Selected Interacting proteins: Q5VU13-VSIG8_HUMAN ENSP00000357080 for VSIG8 Gene via I2D STRING

Gene Ontology (GO) - Biological Process for VSIG8 Gene


No data available for Pathways by source and SIGNOR curated interactions for VSIG8 Gene

Drugs & Compounds for VSIG8 Gene

No Compound Related Data Available

Transcripts for VSIG8 Gene

mRNA/cDNA for VSIG8 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(28) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for VSIG8 Gene

V-set and immunoglobulin domain containing 8:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for VSIG8 Gene

No ASD Table

Relevant External Links for VSIG8 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for VSIG8 Gene

mRNA expression in normal human tissues for VSIG8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for VSIG8 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x25.7) and Skin - Sun Exposed (Lower leg) (x6.7).

Protein differential expression in normal tissues from HIPED for VSIG8 Gene

This gene is overexpressed in Hair follicle (39.0), Bone marrow mesenchymal stem cell (15.7), and Plasma (11.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for VSIG8 Gene

SOURCE GeneReport for Unigene cluster for VSIG8 Gene Hs.647718

genes like me logo Genes that share expression patterns with VSIG8: view

Protein tissue co-expression partners for VSIG8 Gene

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for VSIG8 Gene

Orthologs for VSIG8 Gene

This gene was present in the common ancestor of chordates.

Orthologs for VSIG8 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia VSIG8 35
  • 87.33 (n)
  • 85.96 (a)
VSIG8 36
  • 86 (a)
(Canis familiaris)
Mammalia VSIG8 35
  • 89.08 (n)
  • 89.32 (a)
VSIG8 36
  • 90 (a)
(Mus musculus)
Mammalia Vsig8 35
  • 88.14 (n)
  • 86.92 (a)
Vsig8 16
Vsig8 36
  • 86 (a)
(Pan troglodytes)
Mammalia VSIG8 35
  • 97.25 (n)
  • 96.84 (a)
VSIG8 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Vsig8 35
  • 87.81 (n)
  • 88.38 (a)
(Monodelphis domestica)
Mammalia VSIG8 36
  • 82 (a)
(Ornithorhynchus anatinus)
Mammalia VSIG8 36
  • 65 (a)
(Anolis carolinensis)
Reptilia VSIG8 36
  • 49 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100495227 35
  • 53.42 (n)
  • 41.67 (a)
(Danio rerio)
Actinopterygii vsig8a 36
  • 28 (a)
vsig8b 36
  • 31 (a)
Species with no ortholog for VSIG8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for VSIG8 Gene

Gene Tree for VSIG8 (if available)
Gene Tree for VSIG8 (if available)

Paralogs for VSIG8 Gene

genes like me logo Genes that share paralogs with VSIG8: view

Variants for VSIG8 Gene

Sequence variations from dbSNP and Humsavar for VSIG8 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs2494502 -- 159,857,432(+) TAGCC(A/G)GGTGC intron-variant
rs2494503 -- 159,857,666(+) TGATA(A/G)CCCAA intron-variant
rs2494504 -- 159,858,338(+) CCAAG(A/G)AGGGC intron-variant
rs2494505 -- 159,859,224(+) GGCTG(C/G/T)TTATG intron-variant
rs2494506 -- 159,859,745(+) CATTG(C/T)GTACT intron-variant

Variation tolerance for VSIG8 Gene

Residual Variation Intolerance Score: 33.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.21; 52.29% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for VSIG8 Gene

Disorders for VSIG8 Gene

Relevant External Links for VSIG8

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for VSIG8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for VSIG8 Gene

Publications for VSIG8 Gene

  1. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 67
  2. Substrate trapping proteomics reveals targets of the I^TrCP2/FBXW11 ubiquitin ligase. (PMID: 25332235) Kim T.Y. … Major M.B. (Mol. Cell. Biol. 2015) 3
  3. Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage. (PMID: 25963833) Drissi R. … Boisvert F.M. (Mol. Cell Proteomics 2015) 3
  4. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. (PMID: 22681889) Baltz A.G. … Landthaler M. (Mol. Cell 2012) 3
  5. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PMID: 22990118) Woods N.T. … Monteiro A.N. (Sci Signal 2012) 3

Products for VSIG8 Gene

Sources for VSIG8 Gene