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VSIG8 Gene

protein-coding   GIFtS: 38
GCID: GC01M159824

V-Set And Immunoglobulin Domain Containing 8

  Search for VSIG8
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
V-Set And Immunoglobulin Domain Containing 81 2
V-Set And Immunoglobulin Domain-Containing Protein 82
C1orf2043

External Ids:    HGNC: 320631   Entrez Gene: 3911232   Ensembl: ENSG000002432847   UniProtKB: Q5VU133   

Export aliases for VSIG8 gene to outside databases

Previous GC identifers: GC01M156638 GC01M158070 GC01M131180


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for VSIG8 Gene:
VSIG8 (V-set and immunoglobulin domain containing 8) is a protein-coding gene. An important paralog of this gene is CLMP.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NC_018912.2  NT_004487.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the VSIG8 gene promoter:
         RFX1   Pax-5   AREB6   SRY   CBF-B   ARP-1   STAT3   CP1A   NF-kappaB1   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): VSIG8 promoter sequence
   Search Chromatin IP Primers for VSIG8

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat VSIG8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q23.2   Ensembl cytogenetic band:  1q23.2   HGNC cytogenetic band: 1q23.2

VSIG8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
VSIG8 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M159824:  view genomic region     (about GC identifiers)

Start:
159,824,106 bp from pter      End:
159,832,447 bp from pter
Size:
8,342 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: VSIG8_HUMAN, Q5VU13 (See protein sequence)
Recommended Name: V-set and immunoglobulin domain-containing protein 8 precursor  
Size: 414 amino acids; 43891 Da
Sequence caution: Sequence=AK096506; Type=Erroneous termination; Positions=409; Note=Translated as Lys;
Secondary accessions: Q5VU14
Alternative splicing: 2 isoforms:  Q5VU13-1   Q5VU13-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for VSIG8: NX_Q5VU13

Explore proteomics data for VSIG8 at MOPED


See VSIG8 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_001013683.1  
ENSEMBL proteins: 
 ENSP00000357080  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
VSET: Immunoglobulin superfamily / V-set domain containing

5 InterPro protein domains:
 IPR003598 Ig_sub2
 IPR013783 Ig-like_fold
 IPR013106 Ig_V-set
 IPR007110 Ig-like_dom
 IPR003599 Ig_sub

Graphical View of Domain Structure for InterPro Entry Q5VU13

ProtoNet protein and cluster: Q5VU13

1 Blocks protein domain: IPB003598 Immunoglobulin C-2 type

UniProtKB/Swiss-Prot: VSIG8_HUMAN, Q5VU13
Similarity: Contains 2 Ig-like V-type (immunoglobulin-like) domains


VSIG8 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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     Gene Ontology (GO): 2 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005515protein binding ----
GO:0044822poly(A) RNA binding IDA--
     
VSIG8 for ontologies           About GeneDecksing


Phenotypes:
     1 MGI phenotypic allele for Vsig8 (no phenotypes)

VSIG8 for phenotypes           About GeneDecksing

Animal Models:
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SwitchGear 3'UTR luciferase reporter plasmidVSIG8 3' UTR sequence
Inhib. RNA
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Predesigned siRNA for gene silencing in human, mouse, rat VSIG8

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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
VSIG8_HUMAN, Q5VU13: Membrane; Single-pass type I membrane protein (Potential)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
plasma membrane3
extracellular2
mitochondrion1
peroxisome1

Gene Ontology (GO): 2 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005622intracellular IEA--
GO:0016021integral component of membrane IEA--

VSIG8 for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for VSIG8
Interactions:

    Search GeneGlobe Interaction Network for VSIG8

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

2 Interacting proteins for VSIG8 (Q5VU133 ENSP000003570804) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
USP15Q9Y4E83, ENSP000002581234I2D: score=2 STRING: ENSP00000258123
--Q6FG913I2D: score=1 
About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for VSIG8



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for VSIG8 gene: 
NM_001013661.1  

Unigene Cluster for VSIG8:

V-set and immunoglobulin domain containing 8
Hs.647718  [show with all ESTs]
Unigene Representative Sequence: AK096506
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000368100(uc001fuh.3)
miRNA
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8 qRT-PCR Assays for microRNAs that regulate VSIG8:
hsa-miR-200a hsa-miR-218 hsa-miR-342-3p hsa-miR-3191 hsa-miR-141 hsa-miR-2355-5p hsa-miR-3144-5p hsa-miR-3670
SwitchGear 3'UTR luciferase reporter plasmidVSIG8 3' UTR sequence
Inhib. RNA
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Predesigned siRNA for gene silencing in human, mouse, rat VSIG8
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  QuantiFast Probe-based Assays in human, mouse, rat VSIG8

Additional mRNA sequence: 

AK096506.1 AL080176.1 BC132893.1 BC132895.1 

13 DOTS entries:

DT.95185675  DT.92067168  DT.441784  DT.100777798  DT.75142807  DT.100715115  DT.91708049  DT.99950210 
DT.100777799  DT.121405895  DT.121405973  DT.91708048  DT.97815630 

Selected AceView cDNA sequences (see all 28):

BI754345 CR612954 CR625159 AI929596 AL539000 AL566788 AL537381 BX355705 
AK096506 BI753917 AL080176 AI564334 AL134415 BX350034 AA565796 BI914871 
BX387040 CD625120 BX355704 AL567611 BI917650 AW847186 AW847152 AW847181 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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VSIG8 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: ACACTAAGTG
VSIG8 Expression
About this image


VSIG8 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 2) fully expand
 
 Ovary (Reproductive System)
         Cumulus Cells Antral Follicle
 
 Epidermis (Integumentary System)
VSIG8 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

VSIG8 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.647718
    Custom PCR Arrays for VSIG8
Primer
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VSIG8

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for VSIG8 gene from Selected species (see all 10)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Vsig81 , 5 V-set and immunoglobulin domain containing 81, 5 88.14(n)1
86.92(a)1
  1 (79.95 cM)5
2409161  NM_177723.41  NP_808391.21 
 1725559385 
lizard
(Anolis carolinensis)
Reptilia VSIG86
V-set and immunoglobulin domain containing 8
49(a)
1 ↔ 1
GL344002.1(16313-25652)
tropical clawed frog
(Xenopus tropicalis)
Amphibia LOC1004952271 coxsackievirus and adenovirus receptor homolog 53.42(n)
41.67(a)
  100495227  XM_004917575.1  XP_004917632.1 
zebrafish
(Danio rerio)
Actinopterygii vsig8b6
vsig8a6
V-set and immunoglobulin domain containing 8a
31(a)
28(a)
1 ↔ many
1 ↔ many
8(7146589-7181578) ENSDARG00000013685
10(19556080-19580283) ENSDARG00000054050


ENSEMBL Gene Tree for VSIG8 (if available)
TreeFam Gene Tree for VSIG8 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for VSIG8 gene
CLMP2  ESAM2  GPA332  VSIG12  CXADR2  VSIG22  C1orf2042  IGSF112  

VSIG8 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for VSIG8 (see all 196)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 1 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1137670951,2
C--159827156(+) GTCAGG/AAGTTT 1 -- int11Minor allele frequency- A:0.50CSA 2
rs1460315781,2
C--159827187(+) GGTAAA/TACCCC 1 -- int10--------
rs1869213351,2
--159827221(+) TTAGCC/TAGGTG 1 -- int10--------
rs24945021,2
C,F,A--159827222(+) TAGCCG/AGGTGC 1 -- int15Minor allele frequency- A:0.44NA CSA 9
rs1417672141,2
C--159827236(+) GGTGCA/GTGCCT 1 -- int10--------
rs75124781,2
C,A--159827241(+) atgccC/Tgtaat 1 -- int12Minor allele frequency- T:0.25WA NA 4
rs106837981,2
C--159827366(+) aaaaa-/A/AAA 
        
aaaaa
2 -- int1 cds11NA 2
rs44772681,2
C,F,A,H--159827416(+) AGGGTC/ATCCCA 1 -- int18Minor allele frequency- A:0.41NA WA CSA EA 367
rs24945031,2
C,F,A--159827456(+) TGATAG/ACCCAA 1 -- int110Minor allele frequency- A:0.39NA WA CSA EA 372
rs115842001,2
C,F,H--159827475(+) CAACAG/AGTCCC 1 -- int18Minor allele frequency- A:0.41NA WA CSA EA 367

HapMap Linkage Disequilibrium report for VSIG8 (159824106 - 159832447 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for VSIG8: --
Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing VSIG8
DNA2.0 Custom Variant and Variant Library Synthesis for VSIG8

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for VSIG8 gene integrated from 10 sources:
(articles sorted by number of sources associating them with VSIG8)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (Sci Signal 2012)
  2. Defining the human deubiquitinating enzyme interaction landscape. (PubMed id 19615732)1 Sowa M.E....Harper J.W. (Cell 2009)
  3. Charting the molecular network of the drug target Bcr-Abl. (PubMed id 19380743)1 Brehme M....Superti-Furga G. (Proc. Natl. Acad. Sci. U.S.A. 2009)
  4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W.... Wilson R.K. (Nature 2005)
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)
  7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 391123 HGNC: 32063 AceView: LOC391123 Ensembl:ENSG00000243284 euGenes: HUgn391123
ECgene: VSIG8 H-InvDB: VSIG8

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for VSIG8 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for VSIG8 gene:
Search GeneIP for patents involving VSIG8

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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 Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

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 inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for VSIG8
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GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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