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Aliases for VSIG8 Gene

Aliases for VSIG8 Gene

  • V-Set And Immunoglobulin Domain Containing 8 2 3
  • C1orf204 4

External Ids for VSIG8 Gene

Summaries for VSIG8 Gene

GeneCards Summary for VSIG8 Gene

VSIG8 (V-Set And Immunoglobulin Domain Containing 8) is a Protein Coding gene. An important paralog of this gene is CXADR.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VSIG8 Gene

Genomics for VSIG8 Gene

Genomic Location for VSIG8 Gene

Start:
159,854,316 bp from pter
End:
159,862,657 bp from pter
Size:
8,342 bases
Orientation:
Minus strand

Genomic View for VSIG8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for VSIG8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VSIG8 Gene

Regulatory Elements for VSIG8 Gene

Proteins for VSIG8 Gene

  • Protein details for VSIG8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5VU13-VSIG8_HUMAN
    Recommended name:
    V-set and immunoglobulin domain-containing protein 8
    Protein Accession:
    Q5VU13
    Secondary Accessions:
    • Q5VU14

    Protein attributes for VSIG8 Gene

    Size:
    414 amino acids
    Molecular mass:
    43891 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AK096506; Type=Erroneous termination; Positions=409; Note=Translated as Lys.; Evidence={ECO:0000305};

    Alternative splice isoforms for VSIG8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for VSIG8 Gene

Proteomics data for VSIG8 Gene at MOPED

Post-translational modifications for VSIG8 Gene

No Post-translational modifications

Other Protein References for VSIG8 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for VSIG8 Gene

Domains for VSIG8 Gene

Gene Families for VSIG8 Gene

HGNC:
  • VSET :Immunoglobulin superfamily / V-set domain containing

Protein Domains for VSIG8 Gene

UniProtKB/Swiss-Prot:

VSIG8_HUMAN
Domain:
  • Contains 2 Ig-like V-type (immunoglobulin-like) domains.:
    • Q5VU13
genes like me logo Genes that share domains with VSIG8: view

Function for VSIG8 Gene

Gene Ontology (GO) - Molecular Function for VSIG8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0044822 poly(A) RNA binding IDA 22681889
genes like me logo Genes that share ontologies with VSIG8: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for VSIG8 Gene

Localization for VSIG8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for VSIG8 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for VSIG8 Gene COMPARTMENTS Subcellular localization image for VSIG8 gene
Compartment Confidence
plasma membrane 3
extracellular 2
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for VSIG8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with VSIG8: view

Pathways for VSIG8 Gene

SuperPathways for VSIG8 Gene

No Data Available

Interacting Proteins for VSIG8 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000357080%0d%0a9606.ENSP00000258123%0d%0a9606.ENSP00000264431%0d%0a9606.ENSP00000360798%0d%0a
Selected Interacting proteins: ENSP00000357080 Q5VU13-VSIG8_HUMAN for VSIG8 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for VSIG8 Gene

None

No data available for Pathways by source for VSIG8 Gene

Transcripts for VSIG8 Gene

mRNA/cDNA for VSIG8 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(28) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for VSIG8 Gene

V-set and immunoglobulin domain containing 8:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for VSIG8 Gene

No ASD Table

Relevant External Links for VSIG8 Gene

GeneLoc Exon Structure for
VSIG8
ECgene alternative splicing isoforms for
VSIG8

Expression for VSIG8 Gene

mRNA expression in normal human tissues for VSIG8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for VSIG8 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (25.7) and Skin - Sun Exposed (Lower leg) (6.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for VSIG8 Gene

SOURCE GeneReport for Unigene cluster for VSIG8 Gene Hs.647718

genes like me logo Genes that share expressions with VSIG8: view

Orthologs for VSIG8 Gene

This gene was present in the common ancestor of chordates.

Orthologs for VSIG8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia VSIG8 36
  • 97.25 (n)
  • 96.84 (a)
VSIG8 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia VSIG8 36
  • 87.33 (n)
  • 85.96 (a)
VSIG8 37
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia VSIG8 36
  • 89.08 (n)
  • 89.32 (a)
VSIG8 37
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Vsig8 36
  • 88.14 (n)
  • 86.92 (a)
Vsig8 16
Vsig8 37
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia VSIG8 37
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia VSIG8 37
  • 65 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Vsig8 36
  • 87.81 (n)
  • 88.38 (a)
lizard
(Anolis carolinensis)
Reptilia VSIG8 37
  • 49 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100495227 36
  • 53.42 (n)
  • 41.67 (a)
zebrafish
(Danio rerio)
Actinopterygii vsig8a 37
  • 28 (a)
OneToMany
vsig8b 37
  • 31 (a)
OneToMany
Species with no ortholog for VSIG8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for VSIG8 Gene

ENSEMBL:
Gene Tree for VSIG8 (if available)
TreeFam:
Gene Tree for VSIG8 (if available)

Paralogs for VSIG8 Gene

Paralogs for VSIG8 Gene

genes like me logo Genes that share paralogs with VSIG8: view

Variants for VSIG8 Gene

Sequence variations from dbSNP and Humsavar for VSIG8 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs2494502 -- 159,857,432(+) TAGCC(A/G)GGTGC intron-variant
rs2494503 -- 159,857,666(+) TGATA(A/G)CCCAA intron-variant
rs2494504 -- 159,858,338(+) CCAAG(A/G)AGGGC intron-variant
rs2494505 -- 159,859,224(+) GGCTG(C/T)TTATG intron-variant
rs2494506 -- 159,859,745(+) CATTG(C/T)GTACT intron-variant

Relevant External Links for VSIG8 Gene

HapMap Linkage Disequilibrium report
VSIG8

No data available for Structural Variations from Database of Genomic Variants (DGV) for VSIG8 Gene

Disorders for VSIG8 Gene

No disorders were found for VSIG8 Gene.

No data available for UniProtKB/Swiss-Prot for VSIG8 Gene

Publications for VSIG8 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  2. Charting the molecular network of the drug target Bcr-Abl. (PMID: 19380743) Brehme M. … Superti-Furga G. (Proc. Natl. Acad. Sci. U.S.A. 2009) 3
  3. Defining the human deubiquitinating enzyme interaction landscape. (PMID: 19615732) Sowa M.E. … Harper J.W. (Cell 2009) 3
  4. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. (PMID: 22681889) Baltz A.G. … Landthaler M. (Mol. Cell 2012) 3
  5. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PMID: 22990118) Woods N.T. … Monteiro A.N. (Sci Signal 2012) 3

Products for VSIG8 Gene

Sources for VSIG8 Gene

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