VSIG8 Gene
protein-coding GIFtS: 37
GCID: GC01M159824
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V-set and immunoglobulin domain containing 8
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Aliases
for VSIG8 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| V-Set And Immunoglobulin Domain Containing 81 2 | | V-Set And Immunoglobulin Domain-Containing Protein 82 | | C1orf2043 |
Export aliases for VSIG8 gene to outside databasesPrevious GC identifers: GC01M156638 GC01M158070 GC01M131180 |
Summaries
for VSIG8 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for VSIG8 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_004487.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the VSIG8 gene promoter:
RFX1 Pax-5 AREB6 SRY CBF-B ARP-1 STAT3 CP1A NF-kappaB1 CBF(2)
Other transcription factors
Search SABiosciences Chromatin IP Primers for VSIG8
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat VSIG8 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1q23.2 Ensembl cytogenetic band: 1q23.2 HGNC cytogenetic band: 1q23.2VSIG8 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M159824: view genomic region
(about GC identifiers)
Start:
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159,824,106 bp from pter |
End:
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159,832,447 bp from pter |
Size:
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8,342 bases |
Orientation:
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minus strand |
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Proteins
for VSIG8 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: VSIG8_HUMAN, Q5VU13 (See
protein sequence)Recommended Name: V-set and immunoglobulin domain-containing protein 8 precursor Size: 414 amino acids; 43891 Da
Subcellular location: Membrane; Single-pass type I membrane protein (Potential)
Sequence caution: Sequence=AK096506; Type=Erroneous termination; Positions=409; Note=Translated as Lys;
Secondary accessions: Q5VU14Alternative splicing: 2 isoforms: Q5VU13-1 Q5VU13-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for VSIG8: NX_Q5VU13
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q5VU13
VSIG8 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001013683.1
ENSEMBL proteins: ENSP00000357080
Human Recombinant Protein Products for VSIG8:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005622 | intracellular |
IEA | -- | | GO:0016021 | integral to membrane |
IEA | -- |
VSIG8 for ontologies About GeneDecksing
VSIG8 Antibody Products:
Assay Products for VSIG8: |
Protein
Domains /
Families
for VSIG8 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
VSIG8 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q5VU13ProtoNet protein and cluster: Q5VU13 1 Blocks protein family: IPB003598 Immunoglobulin C-2 type
UniProtKB/Swiss-Prot: VSIG8_HUMAN, Q5VU13Similarity: Contains 2 Ig-like V-type (immunoglobulin-like) domains |
Function
for VSIG8 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for VSIG8 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for VSIG8
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: VSIG8 (NM_001013661) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for VSIG8 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VSIG8 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VSIG8 |
|
Pathways & Interactions
for VSIG8 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for VSIG8
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
2 Interacting proteins for VSIG8 (Q5VU133 ENSP000003570804) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for VSIG8 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for VSIG8
Search CenterWatch for drugs/clinical trials and news about VSIG8
|
Transcripts
for VSIG8 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for VSIG8 gene: NM_001013661.1 Unigene Cluster for VSIG8: V-set and immunoglobulin domain containing 8 Hs.647718 [show with all ESTs]Unigene Representative Sequence: AK0965061 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000368100(uc001fuh.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for VSIG8 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for VSIG8
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: VSIG8 (NM_001013661) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for VSIG8 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VSIG8 |
Additional cDNA sequence: AK096506.1 AL080176.1 BC132893.1 BC132895.1 10 DOTS entries: DT.92067168 DT.95185675 DT.75142807 DT.100777798 DT.99950210 DT.100715115 DT.100777799 DT.121405895 DT.121405973 DT.91708049 24/28 AceView cDNA sequences (see all 28): BI754345 CR625159 CR612954 AI929596 BI914871 BI753917 AK096506 AI564334 AL134415 AL537381 BX355705 AL539000 BX387040 BX350034 AL566788 AA565796 AL080176 BX355704 CD625120 AL567611 BI917650 AW847186 AW847152 Z20320
GeneLoc Exon Structure
|
Expression
for VSIG8 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| VSIG8 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACACTAAGTG
About this image
See VSIG8 Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.647718
SABiosciences Custom PCR Arrays for VSIG8
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for VSIG8
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat VSIG8 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat VSIG8 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat VSIG8 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VSIG8 |
Orthologs
for VSIG8 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for VSIG8 gene from 2/10 species (see all 10) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
VSIG86 |
-- |
47(a) |
1 ↔ 1 |
GL344002.1(18225-25652) |
zebrafish
(Danio rerio) |
Actinopterygii |
vsig8b6vsig8a6 |
V-set and immunoglobulin domain containing 8a |
31(a)28(a) |
1 ↔ many1 ↔ many |
8(7146589-7181578) 10(19556080-19580283) |
ENSEMBL Gene Tree for VSIG8 (if available)
TreeFam Gene Tree for VSIG8 (if available) |
Paralogs
for VSIG8 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for VSIG8 gene
- CLMP2 ESAM2 GPA332 JAM22 VSIG12 CXADR2 VSIG22 C1orf2042
- IGSF112 JAM32 F11R2
VSIG8 for paralogs About GeneDecksing
|
Genomic Variants
for VSIG8 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for VSIG8 (159824106 - 159832447 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for VSIG8: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing VSIG8 |
|
Disorders
/ Diseases
for VSIG8 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for VSIG8 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for VSIG8 gene integrated from 9 sources:
(articles sorted by number of sources associating them with VSIG8) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (2012)
- Defining the human deubiquitinating enzyme interactio n landscape. (PubMed id 19615732)1 Sowa M.E....Harper J.W. (2009)
- Charting the molecular network of the drug target Bcr-Abl. (PubMed id 19380743)1 Brehme M....Superti-Furga G. (2009)
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W....Wilson R.K. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for VSIG8 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing VSIG8 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing VSIG8 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing VSIG8 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for VSIG8 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for VSIG8 gene:
Search GeneIP for patents involving VSIG8
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for VSIG8 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for VSIG8 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for VSIG8 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for VSIG8 | | | OriGene Protein Over-expression Lysate for VSIG8 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for VSIG8 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for VSIG8 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for VSIG8 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for VSIG8 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for VSIG8 | | OriGene Custom Protein Services for VSIG8 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat VSIG8 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing VSIG8 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat VSIG8 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat VSIG8 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat VSIG8 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat VSIG8 |
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 |  |  |  | |
| | | | Search Tocris compounds for VSIG8 |
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 | | | VSIG8 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VSIG8 |
|  |  |  |  | | | | Search ThermoFisher Antibodies for VSIG8 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VSIG8 |
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