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Aliases for VSIG8 Gene

Aliases for VSIG8 Gene

  • V-Set And Immunoglobulin Domain Containing 8 2 3 5
  • C1orf204 4

External Ids for VSIG8 Gene

Previous GeneCards Identifiers for VSIG8 Gene

  • GC01M156638
  • GC01M158070
  • GC01M159824
  • GC01M131180

Summaries for VSIG8 Gene

GeneCards Summary for VSIG8 Gene

VSIG8 (V-Set And Immunoglobulin Domain Containing 8) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding. An important paralog of this gene is CXADR.

Additional gene information for VSIG8 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VSIG8 Gene

Genomics for VSIG8 Gene

Regulatory Elements for VSIG8 Gene

Enhancers for VSIG8 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H159908 2.1 FANTOM5 Ensembl ENCODE dbSUPER 13.8 -54.8 -54827 18 FEZF1 YBX1 YY1 ZNF143 SP3 ZC3H11A MEF2D ZNF610 GLIS1 NBN NCSTN ENSG00000272668 SNHG28 VSIG8 SLAMF8 RAD1P2 LOC100287049 ENSG00000256029 TAGLN2 FCRL6
GH01H159888 1.9 FANTOM5 Ensembl ENCODE dbSUPER 11.6 -27.8 -27827 3 HDGF ATF1 SIN3A ZNF2 GLIS2 ZNF143 ZNF207 FOS ATF7 RUNX3 ENSG00000272668 SLAMF8 SNHG28 FCRL6 VSIG8 ENSG00000212161 IGSF9 DUSP23 PIGM SLAMF9
GH01H159881 1.8 FANTOM5 Ensembl ENCODE dbSUPER 6.8 -19.5 -19479 1 PKNOX1 ATF7 FOS DEK ZNF491 ZNF518A ZNF592 MAFF SMARCA4 GLIS1 RPSAP18 ENSG00000272668 SNHG28 LOC100287049 COPA SLAMF8 PIGM DCAF8 CADM3 CADM3-AS1
GH01H159936 1.9 FANTOM5 Ensembl ENCODE dbSUPER 5.9 -78.8 -78801 10 PKNOX1 ATF1 SIN3A ZNF2 ZBTB7B YY1 ETS1 ZNF121 GLIS2 ZNF143 ATP1A4 KCNJ10 IGSF9 NHLH1 LINC01133 VSIG8 CFAP45 VANGL2 TAGLN2
GH01H159817 0.9 ENCODE 11.2 +45.0 44989 0 HDAC1 PKNOX1 FOXA2 ATF1 ARNT RARA FOS ATF7 CREM CEBPB ENSG00000212161 SNHG28 VSIG8 SLAMF8 LOC105371464
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around VSIG8 on UCSC Golden Path with GeneCards custom track

Genomic Location for VSIG8 Gene

159,854,316 bp from pter
159,862,657 bp from pter
8,342 bases
Minus strand

Genomic View for VSIG8 Gene

Genes around VSIG8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
VSIG8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for VSIG8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VSIG8 Gene

Proteins for VSIG8 Gene

  • Protein details for VSIG8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    V-set and immunoglobulin domain-containing protein 8
    Protein Accession:
    Secondary Accessions:
    • Q5VU14

    Protein attributes for VSIG8 Gene

    414 amino acids
    Molecular mass:
    43891 Da
    Quaternary structure:
    No Data Available
    • Sequence=AK096506; Type=Erroneous termination; Positions=409; Note=Translated as Lys.; Evidence={ECO:0000305};

    Alternative splice isoforms for VSIG8 Gene


neXtProt entry for VSIG8 Gene

Post-translational modifications for VSIG8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for VSIG8 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for VSIG8 Gene

Domains & Families for VSIG8 Gene

Gene Families for VSIG8 Gene

Protein Domains for VSIG8 Gene

Suggested Antigen Peptide Sequences for VSIG8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with VSIG8: view

No data available for UniProtKB/Swiss-Prot for VSIG8 Gene

Function for VSIG8 Gene

Phenotypes From GWAS Catalog for VSIG8 Gene

Gene Ontology (GO) - Molecular Function for VSIG8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA 22681889
genes like me logo Genes that share ontologies with VSIG8: view
genes like me logo Genes that share phenotypes with VSIG8: view

Animal Models for VSIG8 Gene

MGI Knock Outs for VSIG8:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for VSIG8
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for VSIG8 Gene

Localization for VSIG8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for VSIG8 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for VSIG8 gene
Compartment Confidence
plasma membrane 3
extracellular 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for VSIG8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with VSIG8: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for VSIG8 Gene

Pathways & Interactions for VSIG8 Gene

SuperPathways for VSIG8 Gene

No Data Available

Gene Ontology (GO) - Biological Process for VSIG8 Gene


No data available for Pathways by source and SIGNOR curated interactions for VSIG8 Gene

Drugs & Compounds for VSIG8 Gene

No Compound Related Data Available

Transcripts for VSIG8 Gene

mRNA/cDNA for VSIG8 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(28) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for VSIG8 Gene

V-set and immunoglobulin domain containing 8:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for VSIG8
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for VSIG8 Gene

No ASD Table

Relevant External Links for VSIG8 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for VSIG8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for VSIG8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for VSIG8 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x25.7) and Skin - Sun Exposed (Lower leg) (x6.7).

Protein differential expression in normal tissues from HIPED for VSIG8 Gene

This gene is overexpressed in Hair follicle (39.0), Bone marrow mesenchymal stem cell (15.7), and Plasma (11.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for VSIG8 Gene

NURSA nuclear receptor signaling pathways regulating expression of VSIG8 Gene:


SOURCE GeneReport for Unigene cluster for VSIG8 Gene:


Evidence on tissue expression from TISSUES for VSIG8 Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with VSIG8: view

Primer Products

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for VSIG8 Gene

Orthologs for VSIG8 Gene

This gene was present in the common ancestor of chordates.

Orthologs for VSIG8 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia VSIG8 33 34
  • 97.25 (n)
(Canis familiaris)
Mammalia VSIG8 33 34
  • 89.08 (n)
(Mus musculus)
Mammalia Vsig8 33 16 34
  • 88.14 (n)
(Rattus norvegicus)
Mammalia Vsig8 33
  • 87.81 (n)
(Bos Taurus)
Mammalia VSIG8 33 34
  • 87.33 (n)
(Monodelphis domestica)
Mammalia VSIG8 34
  • 82 (a)
(Ornithorhynchus anatinus)
Mammalia VSIG8 34
  • 65 (a)
(Anolis carolinensis)
Reptilia VSIG8 34
  • 49 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100495227 33
  • 53.42 (n)
(Danio rerio)
Actinopterygii vsig8b 34
  • 31 (a)
vsig8a 34
  • 28 (a)
Species where no ortholog for VSIG8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for VSIG8 Gene

Gene Tree for VSIG8 (if available)
Gene Tree for VSIG8 (if available)

Paralogs for VSIG8 Gene

Paralogs for VSIG8 Gene

genes like me logo Genes that share paralogs with VSIG8: view

Variants for VSIG8 Gene

Sequence variations from dbSNP and Humsavar for VSIG8 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000290851 -- 159,853,901(+) CCGGA(G/T)GCCTG intron-variant, downstream-variant-500B, upstream-variant-2KB
rs1001205670 -- 159,859,107(+) CTATA(C/T)ATATA intron-variant
rs1001886890 -- 159,856,331(+) TGGGC(A/G)AGCTT intron-variant, upstream-variant-2KB
rs1002216971 -- 159,861,288(+) TAGTG(A/G)TGCCT intron-variant, nc-transcript-variant
rs1002229367 -- 159,854,979(+) TGACG(C/T)GGCTG intron-variant, upstream-variant-2KB, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for VSIG8 Gene

Variant ID Type Subtype PubMed ID
esv3578218 CNV loss 25503493
nsv1005195 CNV gain 25217958

Variation tolerance for VSIG8 Gene

Residual Variation Intolerance Score: 33.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.21; 52.29% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for VSIG8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VSIG8 Gene

Disorders for VSIG8 Gene

Relevant External Links for VSIG8

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for VSIG8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for VSIG8 Gene

Publications for VSIG8 Gene

  1. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  2. An organelle-specific protein landscape identifies novel diseases and molecular mechanisms. (PMID: 27173435) Boldt K … UK10K Rare Diseases Group (Nature communications 2016) 3 60
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 60
  4. Substrate trapping proteomics reveals targets of the βTrCP2/FBXW11 ubiquitin ligase. (PMID: 25332235) Kim TY … Major MB (Molecular and cellular biology 2015) 3 60
  5. Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage. (PMID: 25963833) Drissi R … Boisvert FM (Molecular & cellular proteomics : MCP 2015) 3 60

Products for VSIG8 Gene

Sources for VSIG8 Gene

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