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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

VSIG4 Gene

protein-coding GIFtS: 52
GCID: GC0XM065241

V-set and immunoglobulin domain containing 4

Explore 9 diseases affiliated with
VSIG4 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
V-Set And Immunoglobulin Domain Containing 4¹ ²		Complement Receptor Of The Immunoglobulin Superfamily²
Z39IG¹ ² ³ ⁵		Ig Superfamily Protein²
Protein Z39Ig² ³		V-Set And Immunoglobulin Domain-Containing Protein 4²
CRIg² ³

External Ids:	HGNC: 17032¹	Entrez Gene: 11326²	Ensembl: ENSG00000155659⁷	OMIM: 300353⁵	UniProtKB: Q9Y279³

Export aliases for VSIG4 gene to outside databases

Previous GC identifers: GC0XM065024 GC0XM065158 GC0XM059068

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for VSIG4:

This gene encodes a v-set and immunoglobulin-domain containing protein that is structurally related to the B7 family of

immune regulatory proteins. The encoded protein may be a negative regulator of T-cell responses. This protein is also

a receptor for the complement component 3 fragments C3b and iC3b. Alternate splicing results in multiple transcript

variants. (provided by RefSeq, May 2010)

UniProtKB/Swiss-Prot: VSIG4_HUMAN, Q9Y279

Function: Phagocytic receptor, strong negative regulator of T-cell proliferation and IL2 production. Potent inhibitor

of the alternative complement pathway convertases

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000023.10 NC_018934.1 NT_011669.17

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the VSIG4 gene promoter:
GATA-3 SREBP-1c CUTL1 SREBP-1b GATA-1 CREB SREBP-1a FOXJ2 (long isoform) HOXA5 FOXJ2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: VSIG4 promoter sequence

Search SABiosciences Chromatin IP Primers for VSIG4

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat VSIG4

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq12-q13.3 Ensembl cytogenetic band: Xq12 HGNC cytogenetic band: Xq12-q13.3

VSIG4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
VSIG4 gene location

GeneLoc information about chromosome X GeneLoc Exon Structure

GeneLoc location for GC0XM065241: view genomic region (about GC identifiers)

Start:	65,241,580 bp from pter	End:	65,259,967 bp from pter
Size:	18,388 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: VSIG4_HUMAN, Q9Y279 (See protein sequence)

Recommended Name: V-set and immunoglobulin domain-containing protein 4 precursor

Size: 399 amino acids; 43987 Da

Subcellular location: Membrane; Single-pass type I membrane protein (Probable)

3 PDB 3D structures from and Proteopedia for VSIG4:

2ICC (3D)

2ICE (3D)

2ICF (3D)

Secondary accessions: Q6UXI4

Alternative splicing: 3 isoforms: Q9Y279-1 Q9Y279-2 Q9Y279-3 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for VSIG4: NX_Q9Y279

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9Y279

VSIG4 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (5 alternative transcripts):

NP_001093901.1 NP_001171759.1 NP_001171760.1 NP_001244332.1 NP_009199.1

ENSEMBL proteins:

ENSP00000393108 ENSP00000363869 ENSP00000394143 ENSP00000414594 ENSP00000411581

Human Recombinant Protein Products:

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	OriGene Purified Protein: VSIG4 OriGene Protein Over-expression Lysate (see all 3): VSIG4 OriGene Custom Protein Services for VSIG4
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	Sino Biological Recombinant Protein for VSIG4
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for VSIG4

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016021	integral to membrane	IEA	--

VSIG4 for ontologies About GeneDecksing

VSIG4 Antibody Products:

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	Uscn ELISAs and CLIAs for VSIG4

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

VSIG4 for domains About GeneDecksing

5 InterPro domains/families:

IPR003598 Ig_sub2

IPR007110 Ig-like_dom

IPR003599 Ig_sub

IPR013783 Ig-like_fold

IPR013106 Ig_V-set

Graphical View of Domain Structure for InterPro Entry Q9Y279

ProtoNet protein and cluster: Q9Y279

2 Blocks protein families:

IPB003598 Immunoglobulin C-2 type

IPB013106 Immunoglobulin V-set

UniProtKB/Swiss-Prot: VSIG4_HUMAN, Q9Y279

Similarity: Contains 2 Ig-like (immunoglobulin-like) domains

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: VSIG4_HUMAN, Q9Y279

Function: Phagocytic receptor, strong negative regulator of T-cell proliferation and IL2 production. Potent inhibitor

of the alternative complement pathway convertases

miRNA Products:		OriGene 3'-UTR Clone (see all 2): VSIG4 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat VSIG4
		8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate VSIG4 (see all 9):
		hsa-miR-124* hsa-miR-328 hsa-miR-642a hsa-miR-3154 hsa-miR-298 hsa-miR-2114* hsa-miR-3145-3p hsa-miR-1291

		SwitchGear 3'UTR luciferase reporter plasmid: VSIG4 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for VSIG4 (see all 7) OriGene shRNA RFP: VSIG4 OriGene siRNA: VSIG4
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat VSIG4

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for VSIG4

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for VSIG4 (see all 6) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for VSIG4 (see all 5) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 4): VSIG4 (NM_001184831)
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		DNA2.0 Custom Codon Optimized Gene Synthesis Service for VSIG4
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VSIG4

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for VSIG4
		Search LifeMap BioReagents cell lines for VSIG4

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VSIG4

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	16530040

VSIG4 for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for VSIG4:

Increased G1 DNA content

Synthetic lethal with c-Myc af

Animal Models:
Mouse knock-out Vsig4^tm1Gne for VSIG4
4 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Vsig4):

hematopoietic system

homeostasis/metabolism

immune system

mortality/aging

VSIG4 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for VSIG4

STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

2 Interacting proteins for VSIG4 (Q9Y279^{1, 3} ENSP00000363869⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
C3	P01024¹^,³, ENSP00000245907⁴	EBI-903148,EBI-905851 I2D: score=1 STRING: ENSP00000245907
PDK2	ENSP00000007708⁴	STRING: ENSP00000007708

About this table

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006957	complement activation, alternative pathway	IEA	--
GO:0032703	negative regulation of interleukin-2 production	IEA	--
GO:0042130	negative regulation of T cell proliferation	IEA	--

VSIG4 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for VSIG4
Search CenterWatch for drugs/clinical trials and news about VSIG4

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for VSIG4 gene (5 alternative transcripts):

NM_001100431.1 NM_001184830.1 NM_001184831.1 NM_001257403.1 NM_007268.2

Unigene Cluster for VSIG4:

V-set and immunoglobulin domain containing 4

Hs.8904 [show with all ESTs]

Unigene Representative Sequence: NM_001184830

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000427538 ENST00000374737 ENST00000412866 ENST00000423830 ENST00000455586(uc004dwh.2 uc004dwi.2 uc004dwj.3 uc011moy.2)

miRNA Products:		OriGene 3'-UTR Clone (see all 2): VSIG4 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat VSIG4
		8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate VSIG4 (see all 9):
		hsa-miR-124* hsa-miR-328 hsa-miR-642a hsa-miR-3154 hsa-miR-298 hsa-miR-2114* hsa-miR-3145-3p hsa-miR-1291

		SwitchGear 3'UTR luciferase reporter plasmid: VSIG4 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for VSIG4 (see all 7) OriGene shRNA RFP: VSIG4 OriGene siRNA: VSIG4
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat VSIG4

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for VSIG4 (see all 6) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for VSIG4 (see all 5) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 4): VSIG4 (NM_001184831)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for VSIG4
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VSIG4

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for VSIG4 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat VSIG4
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat VSIG4
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat VSIG4

Additional cDNA sequence:

AJ132502.1 AK075153.1 AK075171.1 AK293215.1 AK297050.1 AK298389.1 AK301417.1 AY358341.1

BC010525.1

11 DOTS entries:

DT.40123029 DT.100666248 DT.100685545 DT.95111356 DT.95372655 DT.100866909 DT.121317625 DT.100702090

DT.100867983 DT.121317617 DT.95111349

24/221 AceView cDNA sequences (see all 221):

CR603531 AA486747 BF343961 CR605065 CR618957 BI761388 BM970590 AJ132502

BQ016950 AL552873 AL553495 AL542949 CR597253 CR611365 AL545544 BQ026397

BC010525 AL552598 CR624751 BM705163 AI088635 AV690218 CB164451 AK075171

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for VSIG4 About this scheme

ExUns:	1a	·	1b	^	2a	·	2b	^	3a	·	3b	^	4	^	5	^	6	^	7
SP1:
SP2:									-		-
SP3:							-		-

ECgene alternative splicing isoforms for VSIG4

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

VSIG4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCTACAGACA

About this image

VSIG4 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Adipose

Visceral White Adipose

Adipose

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See VSIG4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for VSIG4

SOURCE GeneReport for Unigene cluster: Hs.8904

UniProtKB/Swiss-Prot: VSIG4_HUMAN, Q9Y279

Tissue specificity: Abundantly expressed in several fetal tissues. In adult tissues, highest expression in lung and

placenta. Expressed in resting macrophages

SABiosciences Custom PCR Arrays for VSIG4

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VSIG4

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for VSIG4 gene from 3/8 species (see all 8) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Vsig4^{1 , 5}	V-set and immunoglobulin domain containing 4^{1, 5}	76.86(n)¹ 65.28(a)¹		X (42.69 cM)⁵ 278180¹ NM_177789.4¹ NP_808457.1¹ 96247203⁵
chicken (Gallus gallus)	Aves	VSIG4⁶	Uncharacterized protein	35(a)	1 ↔ 1	4(241320-244827)
lizard (Anolis carolinensis)	Reptilia	VSIG4⁶	--	37(a)	1 ↔ 1	GL343465.1(627806-630212)

ENSEMBL Gene Tree for VSIG4 (if available)
TreeFam Gene Tree for VSIG4 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr X pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs147532440^1,2		--	65241313(+)	`CAGTTG/TATGTG`	5	--	ds500¹		0	--	--	--	--
rs140155033^1,2		--	65241337(+)	`AGGTGA/GACCTG`	5	--	ds500¹		0	--	--	--	--
rs145685515^1,2		--	65241400(+)	`ATTCAC/GTGTTC`	5	--	ds500¹		0	--	--	--	--
rs147127793^1,2		--	65241402(+)	`TCACTA/GTTCTC`	5	--	ds500¹		0	--	--	--	--
rs139467643^1,2		--	65241404(+)	`ACTGTA/TCTCCA`	5	--	ds500¹		0	--	--	--	--
rs149689885^1,2		--	65241411(+)	`TCCAGC/GTGGGC`	5	--	ds500¹		0	--	--	--	--
rs145536884^1,2		--	65241436(+)	`AAGTAA/GGAGTG`	5	--	ds500¹		0	--	--	--	--
rs185741172^1,2		--	65241638(+)	`ACTTAG/TAGTGG`	5	--	ut3¹		0	--	--	--	--
rs190057546^1,2		--	65241670(+)	`CCTGTG/TAAATA`	5	--	ut3¹		0	--	--	--	--
rs1044165^1,2	C,F,O,A,H,	--	65241726(-)	`TATATT/CCAGGA`	5	--	ut3¹ ese³		20		MN NA NS EA	1831

HapMap Linkage Disequilibrium report for VSIG4 (65241580 - 65259967 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for VSIG4: --
Human Gene Mutation Database (HGMD): VSIG4

Locus Specific Mutation Databases (LSDB): VSIG4

SABiosciences Cancer Mutation PCR Assays

Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing VSIG4

DNA2.0 Custom Variant and Variant Library Synthesis for VSIG4

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

VSIG4 for disorders           About GeneDecksing

OMIM gene information: 300353    OMIM disorders: --

9 diseases for VSIG4:    About MalaCards

b-cell lymphomas urethral obstruction urethritis rheumatoid arthritis

arthritis colorectal cancer atherosclerosis leukemia

neuronitis

Export disorders for VSIG4 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for VSIG4 gene, integrated from 9 sources (see all 38):
(articles sorted by number of sources associating them with VSIG4)

Utopia: connect your pdf to the dynamic
world of online information

VSIG4, a B7 family-related protein, is a negative regulator of T cell activation. (PubMed id 17016562)^{1, 2, 3} Vogt L....Bachmann M.F. (2006)
Cloning of Z39Ig, a novel gene with immunoglobulin-like domains located on human chromosome X. (PubMed id 11004523)^{1, 2, 3} Langnaese K.... Wieacker P. (2000)
To be or not to be B7. (PubMed id 17016555)^{1, 3} Zang X. and Allison J.P. (2006)
Structure of C3b in complex with CRIg gives insights into regulation of complement activation. (PubMed id 17051150)^{1, 2} Wiesmann C....van Lookeren Campagne M. (2006)
Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)^{1, 2} Zhang Z. and Henzel W.J. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)^{1, 2} Clark H.F.... Gray A.M. (2003)
Phenotypic and functional profiles of CRIg (Z39Ig)-exp ressing macrophages in the large intestine. (PubMed id 21768202)¹ Tanaka M....Matsuyama T. (2012)
Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)¹ OlA!h J....OvA!di J. (2011)
T-cell/histiocyte-rich large B-cell lymphoma shows tr anscriptional features suggestive of a tolerogenic host immune response. (PubMed id 19797726)¹ Van Loo P....De Wolf-Peeters C. (2010)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 11326	HGNC: 17032	AceView: VSIG4	Ensembl:ENSG00000155659	euGenes: HUgn11326
ECgene: VSIG4	H-InvDB: VSIG4

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for VSIG4	Pharmacogenomics, SNPs, Pathways

Intellectual Property for VSIG4 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for VSIG4 gene:
Search GeneIP for patents involving VSIG4

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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	EMD Millipore Custom Antibody & Bulk Services
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	Antibodies for VSIG4 (VSIG4)		Browse Cell Culture Products
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	Browse Phosphatase Activity Assays/Reagents		Recombinant/Natural Proteins for VSIG4 (VSIG4)

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	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for VSIG4		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for VSIG4
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Search for Antibodies & Assays

	Regulatory tfbs in VSIG4 promoter
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Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

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VSIG4 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for VSIG4

	Gene Synthesis
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VSIG4

	SwitchGear 3'UTR luciferase reporter plasmids for VSIG4
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Search ThermoFisher Antibodies for VSIG4

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VSIG4

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

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Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

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VSIG4 Gene

V-set and immunoglobulin domain containing 4

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VSIG4 Gene

V-set and immunoglobulin domain containing 4

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Intellectual Property
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