Free for academic non-profit institutions. Other users need a Commercial license

Aliases for VSIG4 Gene

Aliases for VSIG4 Gene

  • V-Set And Immunoglobulin Domain Containing 4 2 3
  • Z39IG 3 4 6
  • Protein Z39Ig 3 4
  • CRIg 3 4
  • Complement Receptor Of The Immunoglobulin Superfamily 3
  • V-Set And Immunoglobulin Domain-Containing Protein 4 3
  • Ig Superfamily Protein 3

External Ids for VSIG4 Gene

Previous GeneCards Identifiers for VSIG4 Gene

  • GC0XM065024
  • GC0XM065158
  • GC0XM065241
  • GC0XM059068

Summaries for VSIG4 Gene

Entrez Gene Summary for VSIG4 Gene

  • This gene encodes a v-set and immunoglobulin-domain containing protein that is structurally related to the B7 family of immune regulatory proteins. The encoded protein may be a negative regulator of T-cell responses. This protein is also a receptor for the complement component 3 fragments C3b and iC3b. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2010]

GeneCards Summary for VSIG4 Gene

VSIG4 (V-Set And Immunoglobulin Domain Containing 4) is a Protein Coding gene.

UniProtKB/Swiss-Prot for VSIG4 Gene

  • Phagocytic receptor, strong negative regulator of T-cell proliferation and IL2 production. Potent inhibitor of the alternative complement pathway convertases.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VSIG4 Gene

Genomics for VSIG4 Gene

Regulatory Elements for VSIG4 Gene

Genomic Location for VSIG4 Gene

66,021,738 bp from pter
66,040,125 bp from pter
18,388 bases
Minus strand

Genomic View for VSIG4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for VSIG4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VSIG4 Gene

Proteins for VSIG4 Gene

  • Protein details for VSIG4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    V-set and immunoglobulin domain-containing protein 4
    Protein Accession:
    Secondary Accessions:
    • Q6UXI4

    Protein attributes for VSIG4 Gene

    399 amino acids
    Molecular mass:
    43987 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for VSIG4 Gene

    Alternative splice isoforms for VSIG4 Gene


neXtProt entry for VSIG4 Gene

Proteomics data for VSIG4 Gene at MOPED

Post-translational modifications for VSIG4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for VSIG4 Gene

Antibody Products

No data available for DME Specific Peptides for VSIG4 Gene

Domains for VSIG4 Gene

Protein Domains for VSIG4 Gene

Suggested Antigen Peptide Sequences for VSIG4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 2 Ig-like (immunoglobulin-like) domains.
  • Contains 2 Ig-like (immunoglobulin-like) domains.
genes like me logo Genes that share domains with VSIG4: view

Function for VSIG4 Gene

Molecular function for VSIG4 Gene

UniProtKB/Swiss-Prot Function:
Phagocytic receptor, strong negative regulator of T-cell proliferation and IL2 production. Potent inhibitor of the alternative complement pathway convertases.

Gene Ontology (GO) - Molecular Function for VSIG4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16530040
genes like me logo Genes that share ontologies with VSIG4: view
genes like me logo Genes that share phenotypes with VSIG4: view

Animal Models for VSIG4 Gene

MGI Knock Outs for VSIG4:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targets and HOMER Transcription for VSIG4 Gene

Localization for VSIG4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for VSIG4 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for VSIG4 Gene COMPARTMENTS Subcellular localization image for VSIG4 gene
Compartment Confidence
plasma membrane 3
cytosol 1
endoplasmic reticulum 1
extracellular 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for VSIG4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with VSIG4: view

Pathways for VSIG4 Gene

SuperPathways for VSIG4 Gene

No Data Available

Interacting Proteins for VSIG4 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: ENSP00000363869 Q9Y279-VSIG4_HUMAN for VSIG4 Gene via STRING UniProtKB I2D

Gene Ontology (GO) - Biological Process for VSIG4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006957 complement activation, alternative pathway IEA --
GO:0032703 negative regulation of interleukin-2 production IEA --
GO:0042130 negative regulation of T cell proliferation IEA --
genes like me logo Genes that share ontologies with VSIG4: view

No data available for Pathways by source for VSIG4 Gene

Transcripts for VSIG4 Gene

Unigene Clusters for VSIG4 Gene

V-set and immunoglobulin domain containing 4:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for VSIG4

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for VSIG4 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7
SP2: - -
SP3: - -

Relevant External Links for VSIG4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for VSIG4 Gene

mRNA expression in normal human tissues for VSIG4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for VSIG4 Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (5.2) and Whole Blood (4.4).

Protein differential expression in normal tissues for VSIG4 Gene

This gene is overexpressed in Cerebrospinal fluid (19.5), Plasma (10.7), Pancreas (7.5), and Gallbladder (7.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for VSIG4 Gene

SOURCE GeneReport for Unigene cluster for VSIG4 Gene Hs.8904

mRNA Expression by UniProt/SwissProt for VSIG4 Gene

Tissue specificity: Abundantly expressed in several fetal tissues. In adult tissues, highest expression in lung and placenta. Expressed in resting macrophages.
genes like me logo Genes that share expressions with VSIG4: view

Primer Products

In Situ Assay Products

No data available for Expression partners for VSIG4 Gene

Orthologs for VSIG4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for VSIG4 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia VSIG4 35
  • 83.33 (n)
  • 79.27 (a)
VSIG4 36
  • 73 (a)
(Mus musculus)
Mammalia Vsig4 35
  • 76.89 (n)
  • 65.34 (a)
Vsig4 16
Vsig4 36
  • 63 (a)
(Pan troglodytes)
Mammalia VSIG4 35
  • 99.58 (n)
  • 99.5 (a)
VSIG4 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Vsig4 35
  • 74.12 (n)
  • 63.26 (a)
(Bos Taurus)
Mammalia VSIG4 36
  • 78 (a)
(Monodelphis domestica)
Mammalia VSIG4 36
  • 49 (a)
(Ornithorhynchus anatinus)
Mammalia VSIG4 36
  • 47 (a)
(Gallus gallus)
Aves VSIG4 36
  • 35 (a)
(Anolis carolinensis)
Reptilia VSIG4 36
  • 28 (a)
Species with no ortholog for VSIG4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for VSIG4 Gene

Gene Tree for VSIG4 (if available)
Gene Tree for VSIG4 (if available)

Paralogs for VSIG4 Gene

No data available for Paralogs for VSIG4 Gene

Variants for VSIG4 Gene

Sequence variations from dbSNP and Humsavar for VSIG4 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs13686 -- 66,021,801(+) TAGTG(A/G)AGGAG utr-variant-3-prime
rs621259 -- 66,034,772(+) GGGGG(G/T)GGGGG intron-variant
rs764447 -- 66,041,134(-) CATCT(C/G)TGCAC upstream-variant-2KB
rs1044165 -- 66,021,884(-) TATAT(C/T)CAGGA utr-variant-3-prime
rs2076543 -- 66,024,808(-) TGAAG(A/T)ACAGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for VSIG4 Gene

Variant ID Type Subtype PubMed ID
esv1584074 OTHER Inversion 17803354
nsv6933 CNV Insertion 18451855
nsv513609 CNV Insertion 21212237
nsv6934 CNV Insertion 18451855

Relevant External Links for VSIG4 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)
Locus Specific Mutation Databases (LSDB)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VSIG4 Gene

Disorders for VSIG4 Gene

No disorders were found for VSIG4 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for VSIG4 Gene

Publications for VSIG4 Gene

  1. Cloning of Z39Ig, a novel gene with immunoglobulin-like domains located on human chromosome X. (PMID: 11004523) Langnaese K. … Wieacker P. (Biochim. Biophys. Acta 2000) 2 3 4
  2. VSIG4, a B7 family-related protein, is a negative regulator of T cell activation. (PMID: 17016562) Vogt L. … Bachmann M.F. (J. Clin. Invest. 2006) 2 3 4
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  4. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PMID: 15340161) Zhang Z. … Henzel W.J. (Protein Sci. 2004) 3 4
  5. Structure of C3b in complex with CRIg gives insights into regulation of complement activation. (PMID: 17051150) Wiesmann C. … van Lookeren Campagne M. (Nature 2006) 3 4

Products for VSIG4 Gene

Sources for VSIG4 Gene

Back to Top