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VSIG4 Gene

protein-coding   GIFtS: 52
GCID: GC0XM065241

V-Set And Immunoglobulin Domain Containing 4

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
V-Set And Immunoglobulin Domain Containing 41 2     Complement Receptor Of The Immunoglobulin Superfamily2
Z39IG2 3 5     Ig Superfamily Protein2
Protein Z39Ig2 3     V-Set And Immunoglobulin Domain-Containing Protein 42
CRIg2 3     

External Ids:    HGNC: 170321   Entrez Gene: 113262   Ensembl: ENSG000001556597   OMIM: 3003535   UniProtKB: Q9Y2793   

Export aliases for VSIG4 gene to outside databases

Previous GC identifers: GC0XM065024 GC0XM065158 GC0XM059068


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for VSIG4 Gene:
This gene encodes a v-set and immunoglobulin-domain containing protein that is structurally related to the B7
family of immune regulatory proteins. The encoded protein may be a negative regulator of T-cell responses. This
protein is also a receptor for the complement component 3 fragments C3b and iC3b. Alternate splicing results in
multiple transcript variants. (provided by RefSeq, May 2010)

GeneCards Summary for VSIG4 Gene:
VSIG4 (V-set and immunoglobulin domain containing 4) is a protein-coding gene.

UniProtKB/Swiss-Prot: VSIG4_HUMAN, Q9Y279
Function: Phagocytic receptor, strong negative regulator of T-cell proliferation and IL2 production. Potent
inhibitor of the alternative complement pathway convertases




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000023.10  NC_018934.2  NT_011651.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the VSIG4 gene promoter:
         GATA-3   SREBP-1c   CUTL1   SREBP-1b   GATA-1   CREB   SREBP-1a   FOXJ2 (long isoform)   HOXA5   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidVSIG4 promoter sequence
   Search Chromatin IP Primers for VSIG4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat VSIG4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq12-q13.3   Ensembl cytogenetic band:  Xq12   HGNC cytogenetic band: Xq12-q13.3

VSIG4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
VSIG4 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM065241:  view genomic region     (about GC identifiers)

Start:
65,241,580 bp from pter      End:
65,259,967 bp from pter
Size:
18,388 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: VSIG4_HUMAN, Q9Y279 (See protein sequence)
Recommended Name: V-set and immunoglobulin domain-containing protein 4 precursor  
Size: 399 amino acids; 43987 Da
3 PDB 3D structures from and Proteopedia for VSIG4:
2ICC (3D)        2ICE (3D)        2ICF (3D)    
Secondary accessions: Q6UXI4
Alternative splicing: 3 isoforms:  Q9Y279-1   Q9Y279-2   Q9Y279-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for VSIG4: NX_Q9Y279

Explore proteomics data for VSIG4 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See VSIG4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001093901.1  NP_001171759.1  NP_001171760.1  NP_001244332.1  NP_009199.1  

    ENSEMBL proteins: 
     ENSP00000393108   ENSP00000363869   ENSP00000394143   ENSP00000411581  

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    Cloud-Clone Corp. Proteins for VSIG4

     
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    antibodies-online proteins for VSIG4 (9 products) 

     
    antibodies-online peptides for VSIG4

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    antibodies-online antibodies for VSIG4 (30 products) 

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    antibodies-online kits for VSIG4 (2 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing
    VSET: Immunoglobulin superfamily / V-set domain containing

    5 InterPro protein domains:
     IPR003598 Ig_sub2
     IPR013783 Ig-like_fold
     IPR013106 Ig_V-set
     IPR007110 Ig-like_dom
     IPR003599 Ig_sub

    Graphical View of Domain Structure for InterPro Entry Q9Y279

    ProtoNet protein and cluster: Q9Y279

    2 Blocks protein domains:
    IPB003598 Immunoglobulin C-2 type
    IPB013106 Immunoglobulin V-set


    UniProtKB/Swiss-Prot: VSIG4_HUMAN, Q9Y279
    Similarity: Contains 2 Ig-like (immunoglobulin-like) domains


    Find genes that share domains with VSIG4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: VSIG4_HUMAN, Q9Y279
    Function: Phagocytic receptor, strong negative regulator of T-cell proliferation and IL2 production. Potent
    inhibitor of the alternative complement pathway convertases

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16530040
         
    Find genes that share ontologies with VSIG4           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for VSIG4:
     Increased G1 DNA content  Synthetic lethal with c-Myc af 

         4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Vsig4):
     hematopoietic system  homeostasis/metabolism  immune system  mortality/aging 

    Find genes that share phenotypes with VSIG4           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Vsig4tm1Gne for VSIG4

       genOway: Develop your customized and physiologically relevant rodent model for VSIG4

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    hsa-miR-124* hsa-miR-328 hsa-miR-642a hsa-miR-3154 hsa-miR-298 hsa-miR-2114* hsa-miR-3145-3p hsa-miR-1291
    SwitchGear 3'UTR luciferase reporter plasmidVSIG4 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    VSIG4_HUMAN, Q9Y279: Membrane; Single-pass type I membrane protein (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane3
    cytosol1
    endoplasmic reticulum1
    extracellular1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with VSIG4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for VSIG4
    Interactions:

        Search GeneGlobe Interaction Network for VSIG4

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for VSIG4 (Q9Y2791, 3 ENSP000003638694) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    C3P010241, 3, ENSP000002459074EBI-903144,EBI-905851 I2D: score=1 STRING: ENSP00000245907
    PDK2ENSP000000077084STRING: ENSP00000007708
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006957complement activation, alternative pathway IEA--
    GO:0032703negative regulation of interleukin-2 production IEA--
    GO:0042130negative regulation of T cell proliferation IEA--

    Find genes that share ontologies with VSIG4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for VSIG4



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for VSIG4 gene (5 alternative transcripts): 
    NM_001100431.1  NM_001184830.1  NM_001184831.1  NM_001257403.1  NM_007268.2  

    Unigene Cluster for VSIG4:

    V-set and immunoglobulin domain containing 4
    Hs.8904  [show with all ESTs]
    Unigene Representative Sequence: NM_001184830
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000427538 ENST00000374737 ENST00000412866 ENST00000455586(uc004dwh.2 uc004dwi.2 uc004dwj.3 uc011moy.2)

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    Selected qRT-PCR Assays for microRNAs that regulate VSIG4 (see all 9):
    hsa-miR-124* hsa-miR-328 hsa-miR-642a hsa-miR-3154 hsa-miR-298 hsa-miR-2114* hsa-miR-3145-3p hsa-miR-1291
    SwitchGear 3'UTR luciferase reporter plasmidVSIG4 3' UTR sequence
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    Additional mRNA sequence: 

    AJ132502.1 AK075153.1 AK075171.1 AK293215.1 AK297050.1 AK298389.1 AK301417.1 AY358341.1 
    BC010525.1 

    11 DOTS entries:

    DT.40123029  DT.100666248  DT.100685545  DT.95111356  DT.95372655  DT.100866909  DT.121317625  DT.100702090 
    DT.100867983  DT.121317617  DT.95111349 

    Selected AceView cDNA sequences (see all 221):

    CD515762 CR607860 CB164451 AA486747 AL542949 BF343961 CR603425 NM_007268 
    T48889 AI554367 CA405669 BX358965 AW071975 AL575534 CR614994 CR626818 
    CR624751 AV690218 BP344924 CR595142 CR610574 AL552598 CR624119 CR616282 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for VSIG4    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7
    SP1:                                                            
    SP2:                          -     -                           
    SP3:                    -     -                                 


    ECgene alternative splicing isoforms for VSIG4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    VSIG4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCTACAGACA
    VSIG4 Expression
    About this image


    VSIG4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Adipose (Muscoskeletal System)
             Visceral White Adipose
     
     Liver (Hepatobiliary System)
             Mature Mesothelial Cells Hepatic Mesenchyme
     
     Adrenal Gland (Endocrine System)
    VSIG4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    VSIG4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.8904

    UniProtKB/Swiss-Prot: VSIG4_HUMAN, Q9Y279
    Tissue specificity: Abundantly expressed in several fetal tissues. In adult tissues, highest expression in lung
    and placenta. Expressed in resting macrophages

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for VSIG4 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Vsig41 , 5 V-set and immunoglobulin domain containing 41, 5 76.89(n)1
    65.34(a)1
      X (42.69 cM)5
    2781801  NM_177789.41  NP_808457.11 
     962472035 
    chicken
    (Gallus gallus)
    Aves VSIG46
    V-set and immunoglobulin domain containing 4
    35(a)
    1 ↔ 1
    4(247357-254601)
    lizard
    (Anolis carolinensis)
    Reptilia VSIG46
    V-set and immunoglobulin domain containing 4
    28(a)
    1 ↔ 1
    GL343465.1(621226-634635)


    ENSEMBL Gene Tree for VSIG4 (if available)
    TreeFam Gene Tree for VSIG4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for VSIG4 (see all 434)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1475324401,2
    C--65241313(+) CAGTTG/TATGTG 5 -- ds50010--------
    rs1401550331,2
    --65241337(+) AGGTGA/GACCTG 5 -- ds50010--------
    rs1456855151,2
    --65241400(+) ATTCAC/GTGTTC 5 -- ds50010--------
    rs1471277931,2
    --65241402(+) TCACTA/GTTCTC 5 -- ds50010--------
    rs1394676431,2
    --65241404(+) ACTGTA/TCTCCA 5 -- ds50010--------
    rs1496898851,2
    --65241411(+) TCCAGC/GTGGGC 5 -- ds50010--------
    rs1455368841,2
    C--65241436(+) AAGTAA/GGAGTG 5 -- ds50010--------
    rs1857411721,2
    --65241638(+) ACTTAG/TAGTGG 5 -- ut310--------
    rs1900575461,2
    --65241670(+) CCTGTG/TAAATA 5 -- ut310--------
    rs10441651,2
    C,F,O,A,H--65241726(-) TATATT/CCAGGA 5 -- ut31 ese320Minor allele frequency- C:0.86MN NA NS EA 1831

    HapMap Linkage Disequilibrium report for VSIG4 (65241580 - 65259967 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for VSIG4:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv6934CNV Insertion18451855
    nsv6933CNV Insertion18451855
    nsv513609CNV Insertion21212237
    esv1584074OTHER Inversion17803354

    Human Gene Mutation Database (HGMD): VSIG4
    Locus Specific Mutation Databases (LSDB): VSIG4

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 300353    OMIM disorders: --


    Find genes that share disorders with VSIG4           About GenesLikeMe


    Export disorders for VSIG4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for VSIG4 gene, integrated from 10 sources (see all 40):
    (articles sorted by number of sources associating them with VSIG4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. VSIG4, a B7 family-related protein, is a negative regulator of T cell activation. (PubMed id 17016562)1, 2, 3 Vogt L....Bachmann M.F. (J. Clin. Invest. 2006)
    2. Cloning of Z39Ig, a novel gene with immunoglobulin-like domains located on human chromosome X. (PubMed id 11004523)1, 2, 3 Langnaese K.... Wieacker P. (Biochim. Biophys. Acta 2000)
    3. To be or not to be B7. (PubMed id 17016555)1, 3 Zang X. and Allison J.P. (J. Clin. Invest. 2006)
    4. Structure of C3b in complex with CRIg gives insights into regulation of complement activation. (PubMed id 17051150)1, 2 Wiesmann C....van Lookeren Campagne M. (Nature 2006)
    5. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (Protein Sci. 2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    8. Phenotypic and functional profiles of CRIg (Z39Ig)-expressing macrophages in the large intestine. (PubMed id 21768202)1 Tanaka M....Matsuyama T. (Innate Immun 2012)
    9. Brain transcriptome-wide screen for HIV-1 Nef protein interaction partners reveals various membrane-associated proteins. (PubMed id 23284715)1 Kammula E.C....Willbold D. (PLoS ONE 2012)
    10. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 11326 HGNC: 17032 AceView: VSIG4 Ensembl:ENSG00000155659 euGenes: HUgn11326
    ECgene: VSIG4 H-InvDB: VSIG4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for VSIG4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for VSIG4 gene:
    Search GeneIP for patents involving VSIG4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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