Aliases for VSIG4 Gene
External Ids for VSIG4 Gene
Previous GeneCards Identifiers for VSIG4 Gene
This gene encodes a v-set and immunoglobulin-domain containing protein that is structurally related to the B7 family of immune regulatory proteins. The encoded protein may be a negative regulator of T-cell responses. This protein is also a receptor for the complement component 3 fragments C3b and iC3b. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
GeneCards Summary for VSIG4 Gene
VSIG4 (V-Set And Immunoglobulin Domain Containing 4) is a Protein Coding gene. Diseases associated with VSIG4 include T-Cell/Histiocyte Rich Large B Cell Lymphoma and Langerhans Cell Sarcoma. Among its related pathways are Complement and coagulation cascades.
UniProtKB/Swiss-Prot for VSIG4 Gene
Phagocytic receptor, strong negative regulator of T-cell proliferation and IL2 production. Potent inhibitor of the alternative complement pathway convertases.