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Aliases for VSIG2 Gene

Aliases for VSIG2 Gene

  • V-Set And Immunoglobulin Domain Containing 2 2 3 5
  • Cortical Thymocyte-Like Protein 3 4
  • CT-Like Protein 3 4
  • CTXL 3 4
  • CTH 3 4
  • V-Set And Immunoglobulin Domain-Containing Protein 2 3
  • Cortical Thymocyte Receptor (X. Laevis CTX) Like 3
  • 2210413P10Rik 3

External Ids for VSIG2 Gene

Previous GeneCards Identifiers for VSIG2 Gene

  • GC11M124122
  • GC11M124617
  • GC11M120559

Summaries for VSIG2 Gene

GeneCards Summary for VSIG2 Gene

VSIG2 (V-Set And Immunoglobulin Domain Containing 2) is a Protein Coding gene. An important paralog of this gene is ESAM.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VSIG2 Gene

Genomics for VSIG2 Gene

Regulatory Elements for VSIG2 Gene

Enhancers for VSIG2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G124717 1.5 FANTOM5 Ensembl ENCODE 12.2 +35.1 35091 1.3 WRNIP1 FEZF1 GLIS2 GATA2 FOS JUNB ZNF488 ZNF610 GLIS1 WT1 SPA17 ESAM NRGN ENSG00000255045 VSIG2 SIAE LOC101929340 ROBO3 ROBO4 GC11P124740
GH11G124745 1.5 Ensembl ENCODE dbSUPER 9.9 +5.0 4979 4.4 HDGF FOXA2 PKNOX1 MLX ARID4B SIN3A DMAP1 ZNF2 ZNF48 ETS1 VSIG2 NRGN LOC100507283 ENSG00000255045
GH11G124836 1 Ensembl ENCODE 11 -84.1 -84054 2.0 CTCF SUZ12 ZSCAN4 ZNF384 RAD21 ZFHX2 ZNF143 SMC3 NFE2 KLF7 ROBO3 LOC100507283 MSANTD2 SIAE SPA17 ESAM LOC101929340 VSIG2 ENSG00000255045 NRGN
GH11G124793 0.7 ENCODE 11.7 -40.8 -40835 0.2 CTCF PKNOX1 ZNF654 ESRRA NR2F1 TRIM22 ZNF384 RAD21 KLF16 SCRT2 LOC101929340 ESAM VSIG2 ENSG00000255045 SIAE SPA17 NRGN ROBO3 LOC100507283 ENSG00000279342
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around VSIG2 on UCSC Golden Path with GeneCards custom track

Genomic Location for VSIG2 Gene

124,747,472 bp from pter
124,753,025 bp from pter
5,554 bases
Minus strand

Genomic View for VSIG2 Gene

Genes around VSIG2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
VSIG2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for VSIG2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VSIG2 Gene

Proteins for VSIG2 Gene

  • Protein details for VSIG2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    V-set and immunoglobulin domain-containing protein 2
    Protein Accession:
    Secondary Accessions:
    • O95791
    • Q9NX42

    Protein attributes for VSIG2 Gene

    327 amino acids
    Molecular mass:
    34348 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for VSIG2 Gene


neXtProt entry for VSIG2 Gene

Post-translational modifications for VSIG2 Gene

  • Glycosylation at Asn138 and isoforms=2206
  • Modification sites at PhosphoSitePlus

Other Protein References for VSIG2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for VSIG2
  • Santa Cruz Biotechnology (SCBT) Antibodies for VSIG2

No data available for DME Specific Peptides for VSIG2 Gene

Domains & Families for VSIG2 Gene

Protein Domains for VSIG2 Gene

Suggested Antigen Peptide Sequences for VSIG2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with VSIG2: view

No data available for UniProtKB/Swiss-Prot for VSIG2 Gene

Function for VSIG2 Gene

Phenotypes for VSIG2 Gene

genes like me logo Genes that share phenotypes with VSIG2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for VSIG2

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for VSIG2 Gene

Localization for VSIG2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for VSIG2 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for VSIG2 gene
Compartment Confidence
plasma membrane 5
extracellular 2

Gene Ontology (GO) - Cellular Components for VSIG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane TAS 9862345
GO:0016020 membrane TAS 9862345
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with VSIG2: view

Pathways & Interactions for VSIG2 Gene

SuperPathways for VSIG2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for VSIG2 Gene


No data available for Pathways by source and SIGNOR curated interactions for VSIG2 Gene

Drugs & Compounds for VSIG2 Gene

No Compound Related Data Available

Transcripts for VSIG2 Gene

mRNA/cDNA for VSIG2 Gene

Unigene Clusters for VSIG2 Gene

V-set and immunoglobulin domain containing 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for VSIG2 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8
SP1: - - - -
SP2: - - -
SP3: - -

Relevant External Links for VSIG2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for VSIG2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for VSIG2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for VSIG2 Gene

This gene is overexpressed in Stomach (x21.4), Colon - Transverse (x7.7), and Bladder (x6.2).

Protein differential expression in normal tissues from HIPED for VSIG2 Gene

This gene is overexpressed in Stomach (57.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for VSIG2 Gene

NURSA nuclear receptor signaling pathways regulating expression of VSIG2 Gene:


SOURCE GeneReport for Unigene cluster for VSIG2 Gene:


mRNA Expression by UniProt/SwissProt for VSIG2 Gene:

Tissue specificity: Highly expressed in stomach, colon, prostate, trachea and thyroid glands and weakly in bladder and lung.

Evidence on tissue expression from TISSUES for VSIG2 Gene

  • Intestine(4.2)
  • Stomach(2.4)
genes like me logo Genes that share expression patterns with VSIG2: view

Primer Products

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for VSIG2 Gene

Orthologs for VSIG2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for VSIG2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia VSIG2 34 35
  • 99.49 (n)
(Canis familiaris)
Mammalia VSIG2 34 35
  • 86.86 (n)
(Bos Taurus)
Mammalia VSIG2 34 35
  • 85.89 (n)
(Rattus norvegicus)
Mammalia Vsig2 34
  • 84.57 (n)
(Mus musculus)
Mammalia Vsig2 34 16 35
  • 83.33 (n)
(Monodelphis domestica)
Mammalia VSIG2 35
  • 70 (a)
(Anolis carolinensis)
Reptilia VSIG2 35
  • 46 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia vsig2 34
  • 50.37 (n)
Species where no ortholog for VSIG2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for VSIG2 Gene

Gene Tree for VSIG2 (if available)
Gene Tree for VSIG2 (if available)

Paralogs for VSIG2 Gene

Paralogs for VSIG2 Gene

(2) SIMAP similar genes for VSIG2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with VSIG2: view

Variants for VSIG2 Gene

Sequence variations from dbSNP and Humsavar for VSIG2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000544566 -- 124,752,475(+) TGGAA(A/G)GCGTC upstream-variant-2KB
rs1000573348 -- 124,749,981(+) ACAGT(G/T)GTCCT intron-variant
rs1002037989 -- 124,749,471(+) ACTCT(A/C)TTCCA intron-variant
rs1002778550 -- 124,753,122(+) GGCAA(C/T)TTGTT downstream-variant-500B, upstream-variant-2KB
rs1003102655 -- 124,747,814(+) TCACT(-/C)CCCCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for VSIG2 Gene

Variant ID Type Subtype PubMed ID
esv3627986 CNV gain 21293372
nsv556487 CNV loss 21841781
nsv952751 CNV deletion 24416366

Variation tolerance for VSIG2 Gene

Residual Variation Intolerance Score: 63.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.82; 58.48% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for VSIG2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VSIG2 Gene

Disorders for VSIG2 Gene

Relevant External Links for VSIG2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for VSIG2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for VSIG2 Gene

Publications for VSIG2 Gene

  1. CTX, a Xenopus thymocyte receptor, defines a molecular family conserved throughout vertebrates. (PMID: 9862345) Chretien I. … Du Pasquier L. (Eur. J. Immunol. 1998) 2 3 4 64
  2. Trait-stratified genome-wide association study identifies novel and diverse genetic associations with serologic and cytokine phenotypes in systemic lupus erythematosus. (PMID: 20659327) Kariuki S.N. … Niewold T.B. (Arthritis Res. Ther. 2010) 3 46 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PMID: 15340161) Zhang Z. … Henzel W.J. (Protein Sci. 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for VSIG2 Gene

Sources for VSIG2 Gene

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