VSIG2 Gene
protein-coding GIFtS: 47
GCID: GC11M124617
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|
V-set and immunoglobulin domain containing 2
| |
Aliases
for VSIG2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| V-Set And Immunoglobulin Domain Containing 21 2 | | CT-Like Protein2 3 | | CTH1 2 3 | | 2210413P10Rik2 | | CTXL1 2 3 | | Cortical Thymocyte Receptor (X. Laevis CTX) Like2 | | Cortical Thymocyte-Like Protein2 3 | | V-Set And Immunoglobulin Domain-Containing Protein 22 |
Export aliases for VSIG2 gene to outside databasesPrevious GC identifers: GC11M124122 GC11M120559 |
Summaries
for VSIG2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for VSIG2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_033899.8
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the VSIG2 gene promoter:
POU3F1 STAT5A Nkx2-5 Nkx5-1 POU3F2 Tal-1beta Roaz GATA-1 E47 STAT3
Other transcription factors
Search SABiosciences Chromatin IP Primers for VSIG2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat VSIG2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11q24 Ensembl cytogenetic band: 11q24.2 HGNC cytogenetic band: 11q24VSIG2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11M124617: view genomic region
(about GC identifiers)
Start:
|
124,617,368 bp from pter |
End:
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124,622,134 bp from pter |
Size:
|
4,767 bases |
Orientation:
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minus strand |
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Proteins
for VSIG2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: VSIG2_HUMAN, Q96IQ7 (See
protein sequence)Recommended Name: V-set and immunoglobulin domain-containing protein 2 precursor Size: 327 amino acids; 34348 Da
Subcellular location: Membrane; Single-pass type I membrane protein (Potential)
Secondary accessions: O95791 Q9NX42Alternative splicing: 2 isoforms: Q96IQ7-1 Q96IQ7-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for VSIG2: NX_Q96IQ7
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96IQ7
VSIG2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_055127.2
ENSEMBL proteins: ENSP00000318684 ENSP00000385013
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
VSIG2 for ontologies About GeneDecksing
VSIG2 Antibody Products:
Assay Products for VSIG2: |
Protein
Domains /
Families
for VSIG2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
VSIG2 for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry Q96IQ7ProtoNet protein and cluster: Q96IQ7 1 Blocks protein family: IPB003598 Immunoglobulin C-2 type
UniProtKB/Swiss-Prot: VSIG2_HUMAN, Q96IQ7Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domainSimilarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain |
Function
for VSIG2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for VSIG2 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for VSIG2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: VSIG2 (NM_014312) | |  | Sino Biological Human cDNA Clone for VSIG2 | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for VSIG2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VSIG2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VSIG2 |
Animal Models:
1 MGI phenotypic allele  for Vsig2 (no phenotypes)
VSIG2 for phenotypes About GeneDecksing
|
Pathways & Interactions
for VSIG2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for VSIG2
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
3 Interacting proteins for VSIG2 (ENSP000003186844) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for VSIG2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for VSIG2
Search CenterWatch for drugs/clinical trials and news about VSIG2
|
Transcripts
for VSIG2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for VSIG2 gene: NM_014312.3 Unigene Cluster for VSIG2: V-set and immunoglobulin domain containing 2 Hs.112377 [show with all ESTs]Unigene Representative Sequence: AK0004602 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000326621(uc001qas.3) ENST00000403470(uc001qat.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for VSIG2 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for VSIG2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: VSIG2 (NM_014312) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for VSIG2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VSIG2 |
Additional cDNA sequence: AK000460.1 AY358897.1 BC007313.2 BC012567.1 12 DOTS entries: DT.409702 DT.95373038 DT.97844979 DT.100742599 DT.91640092 DT.91758637 DT.101983021 DT.100754883 DT.100754884 DT.429979 DT.100754886 DT.433596 24/94 AceView cDNA sequences (see all 94): BM742370 BM759000 AW502646 NM_014312 BF221675 BE869001 CF143709 BM743375 CD625546 BQ333151 AI623271 AA630382 BM819765 CF142740 BM748351 BE868917 BM795756 BM831184 AI193494 BM770631 BM758603 AI684054 BU607796 T24595
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for VSIG2 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | · | 7c | ^ | 8 |
|---|
|
| SP1: | | | | | | | - | | - | | | | | | - | | | | | | | | | | - | | | | |
| SP2: | | | | | | | - | | - | | | | | | - | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | - | | | | - | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for VSIG2
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Expression
for VSIG2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| VSIG2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTTCAAGATG
About this image
See VSIG2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for VSIG2
SOURCE GeneReport for Unigene cluster: Hs.112377
UniProtKB/Swiss-Prot: VSIG2_HUMAN, Q96IQ7Tissue specificity: Highly expressed in stomach, colon, prostate, trachea and thyroid glands and weakly in bladder andlung
SABiosciences Custom PCR Arrays for VSIG2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for VSIG2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat VSIG2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat VSIG2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat VSIG2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VSIG2 |
Orthologs
for VSIG2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for VSIG2 gene from 1/8 species (see all 8) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
VSIG26 |
-- |
45(a) |
1 ↔ 1 |
GL343367.1(5040-12724) |
ENSEMBL Gene Tree for VSIG2 (if available)
TreeFam Gene Tree for VSIG2 (if available) |
Paralogs
for VSIG2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for VSIG2 gene
- CLMP2 ESAM2 VSIG82 GPA332 JAM22 VSIG12 CXADR2 C1orf2042
- IGSF112 JAM32 F11R2
2 SIMAP similar genes for VSIG2 using alignment to 1 protein entry: VSIG2_HUMAN:VSIG1 IGSF11
VSIG2 for paralogs About GeneDecksing
|
Genomic Variants
for VSIG2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for VSIG2 (124617368 - 124622134 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for VSIG2: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing VSIG2 |
|
Disorders
/ Diseases
for VSIG2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
VSIG2 for disorders About GeneDecksing
OMIM gene information: 606011
OMIM disorders: --
4  diseases for VSIG2: About MalaCardssystemic lupus erythematosus lupus erythematosus thyroiditis prostatitis
Human Genome Epidemiology (HuGE) Navigator: VSIG2 (1 document)
Export disorders for VSIG2 gene to outside databases
|
Publications
for VSIG2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for VSIG2 gene integrated from 9 sources:
(articles sorted by number of sources associating them with VSIG2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- CTX, a Xenopus thymocyte receptor, defines a molecular family conserved throughout vertebrates. (PubMed id 9862345)1, 2, 3 Chretien I.... Du Pasquier L. (1998)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (2004)
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
- Trait-stratified genome-wide association study identi fies novel and diverse genetic associations with serologic and cytokine phenoty pes in systemic lupus erythematosus. (PubMed id 20659327)1 Kariuki S.N....Niewold T.B. (2010)
- Comparative gene expression profiling of in vitro differentiated megakaryocytes and erythroblasts identifies novel activatory and inhibitory platelet membrane proteins. (PubMed id 17192395)1 Macaulay I.C....Ouwehand W.H. (2007)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for VSIG2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing VSIG2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing VSIG2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing VSIG2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for VSIG2 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for VSIG2 gene:
Search GeneIP for patents involving VSIG2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for VSIG2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for VSIG2 | | OriGene shRNA RFP for VSIG2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for VSIG2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for VSIG2 | | | OriGene Protein Over-expression Lysate for VSIG2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for VSIG2 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for VSIG2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for VSIG2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for VSIG2 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for VSIG2 | | OriGene Custom Protein Services for VSIG2 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat VSIG2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing VSIG2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat VSIG2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat VSIG2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat VSIG2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat VSIG2 |
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 |  |  |  | |
| | | | Search Tocris compounds for VSIG2 |
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 | | | VSIG2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VSIG2 |
|  |  |  | | | | Search ThermoFisher Antibodies for VSIG2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VSIG2 |
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