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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

VSIG10L Gene

protein-coding   GIFtS: 36
GCID: GC19M051834

V-set and immunoglobulin domain containing 10 like
  Search for VSIG10L
in
MalaCards
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 Human Malady Compendium 
Biological research products
for VSIG10L    

Aliases
for VSIG10L gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
V-Set And Immunoglobulin Domain Containing 10 Like1 2
V-Set And Immunoglobulin Domain-Containing Protein 10-Like2

External Ids:    HGNC: 271111   Entrez Gene: 1476452   Ensembl: ENSG000001868067   UniProtKB: Q86VR73   
ORGUL members:         

Export aliases for VSIG10L gene to outside databases

Previous GC identifers: GC19M056528 GC19M048166


Summaries
for VSIG10L gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
  --

Genomic Views
for VSIG10L gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.1  NT_011109.16  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for VSIG10L
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
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Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat VSIG10L


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.41   Ensembl cytogenetic band:  19q13.41   HGNC cytogenetic band: 19q13.41

VSIG10L Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
VSIG10L gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M051834:  view genomic region     (about GC identifiers)

Start:
 51,834,790 bp from pter      End:
 51,845,378 bp from pter
Size:
 10,589 bases      Orientation:
 minus strand

Proteins
for VSIG10L gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: VS10L_HUMAN, Q86VR7 (See protein sequence)
Recommended Name: V-set and immunoglobulin domain-containing protein 10-like precursor  
Size: 867 amino acids; 91625 Da
Subcellular location: Membrane; Single-pass type I membrane protein (Potential)
Alternative splicing: 2 isoforms:  Q86VR7-1   Q86VR7-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for VSIG10L: NX_Q86VR7

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q86VR7

    • VSIG10L Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_001157394.1  
    ENSEMBL proteins: 
     ENSP00000335623  

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    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral to membrane IEA--


    VSIG10L for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for VSIG10L gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    VSIG10L for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR003598 Ig_sub2
     IPR007110 Ig-like_dom
     IPR003599 Ig_sub
     IPR013783 Ig-like_fold

    Graphical View of Domain Structure for InterPro Entry Q86VR7

    ProtoNet protein and cluster: Q86VR7

    UniProtKB/Swiss-Prot: VS10L_HUMAN, Q86VR7
    Similarity: Contains 2 Ig-like C2-type (immunoglobulin-like) domains


    Function
    for VSIG10L gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    miRNA
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    1 GenomeRNAi human phenotype for VSIG10L:
     Increased G2M DNA content, inc 


    Pathways & Interactions
    for VSIG10L gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for VSIG10L

    Drugs & Compounds
    for VSIG10L gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
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    Transcripts
    for VSIG10L gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    About This Section
    REFSEQ mRNAs for VSIG10L gene: 
    NM_001163922.1  

    Unigene Cluster for VSIG10L:

    V-set and immunoglobulin domain containing 10 like
    Hs.293236  [show with all ESTs]
    Unigene Representative Sequence: NM_001163922
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000335624(uc002pwd.3 uc002pwf.3)

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    Inhib. RNA
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    Additional cDNA sequence: 

    AF086436.1 BC016993.1 BC032383.1 BC049212.1 BC131493.1 

    4 DOTS entries:

    DT.103024  DT.95258122  DT.92015958  DT.121491428 

    1 AceView cDNA sequence:

    AI819816 

    GeneLoc Exon Structure


    Expression
    for VSIG10L gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    VSIG10L expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TCACTCTTCT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See VSIG10L Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for VSIG10L

    SOURCE GeneReport for Unigene cluster: Hs.293236
        SABiosciences Custom PCR Arrays for VSIG10L
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    In Situ
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    Orthologs
    for VSIG10L gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for VSIG10L gene from 3/9 species (see all 9)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Vsig10l1 , 5 ZV-set and immunoglobulin domain containing 10 like1, 5 76.28(n)1
    71.17(a)1    		   7 (28.25 cM)5
    756901  XM_355890.71  XP_355890.51 
     434631515 
    lizard
    (Anolis carolinensis)    		 Reptilia VSIG10L6
    		 --
    		 32(a)
    		 1 ↔ 1
    		 GL343281.1(1155393-1193080)
    zebrafish
    (Danio rerio)    		 Actinopterygii LOC1003339751 v-set and immunoglobulin domain-containing protein more 41.42(n)
    30.4(a)    		   100333975  XM_002665044.1  XP_002665090.1 


    ENSEMBL Gene Tree for VSIG10L (if available)
    TreeFam Gene Tree for VSIG10L (if available) 

    Paralogs
    for VSIG10L gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for VSIG10L gene
    VSIG102  

    VSIG10L for paralogs           About GeneDecksing



    Genomic Variants
    for VSIG10L gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/198 NCBI SNPs in VSIG10L are shown (see all 198)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 19 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs746204081,2
    		F,--51834296(+) CCAATC/TATTAA 2 -- ds50011Minor allele frequency- T:0.02EA 120
    rs784887611,2
    		F,--51834385(+) TTCTTC/TGCTGG 2 -- ds50011Minor allele frequency- T:0.06EA 120
    rs357209821,2
    		C,--51834546(+) GTGAT-/AAGAGG 2 -- ds50011Minor allele frequency- A:0.50CSA 2
    rs1825299541,2
    		--51834547(+) AGTGAC/TAGAGG 2 -- ds50010--------
    rs1403374421,2
    		C,--51834601(+) CCTTC-/CTTTT 
                ATCTT     		2 -- ds50010--------
    rs48027821,2
    		C,F,A,H,--51834751(+) ATGGCA/GTTACT 1 -- ds500112Minor allele frequency- G:0.39NA WA CSA EA 376
    rs1871771871,2
    		--51834792(+) CTCCAC/TAGTTC 1 -- ds50010--------
    rs360544921,2
    		C,F,--51834937(+) GGCACC/AAAAAC 1 -- ut313Minor allele frequency- A:0.12WA NA EA 358
    rs1926694971,2
    		--51834989(+) GTGAGG/TCTCTG 1 -- ut310--------
    rs1846069841,2
    		--51835039(+) AAAGCC/TCTTAG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for VSIG10L (51834790 - 51845378 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for VSIG10L: --

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    Disorders / Diseases
    for VSIG10L gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    		   --

    Publications
    for VSIG10L gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for VSIG10L gene integrated from 9 sources:
    (articles sorted by number of sources associating them with VSIG10L)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    2. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)

    External Searches for VSIG10L gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing VSIG10L gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 147645 HGNC: 27111 AceView: LOC147645.1 Ensembl:ENSG00000186806 euGenes: HUgn147645
    ECgene: VSIG10L H-InvDB: VSIG10L

    Other Databases showing VSIG10L gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing VSIG10L gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for VSIG10L Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for VSIG10L gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for VSIG10L gene:
    Search GeneIP for patents involving VSIG10L

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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    VWF
    (GIFTS: 73)
    von Willebrand factor
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