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Aliases for VSIG10L Gene

Aliases for VSIG10L Gene

  • V-Set And Immunoglobulin Domain Containing 10 Like 2 3 5

External Ids for VSIG10L Gene

Previous GeneCards Identifiers for VSIG10L Gene

  • GC19M056528
  • GC19M051834
  • GC19M048166

Summaries for VSIG10L Gene

GeneCards Summary for VSIG10L Gene

VSIG10L (V-Set And Immunoglobulin Domain Containing 10 Like) is a Protein Coding gene. An important paralog of this gene is VSIG10L2.

Additional gene information for VSIG10L Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VSIG10L Gene

Genomics for VSIG10L Gene

Regulatory Elements for VSIG10L Gene

Enhancers for VSIG10L Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19H051360 1.7 Ensembl ENCODE dbSUPER 14.4 -22.8 -22820 8 MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC PPARGC1A MEF2D ZNF175 ZNF577 ZNF766 ZNF836 ZNF841 ZNF616 LOC100419835 ZNF614 ZNF350 ZNF649
GH19H051349 1.1 ENCODE 14.2 -9.3 -9273 3 HDGF PKNOX1 FOXA2 ATF1 ARNT SIN3A DMAP1 YY1 TCF12 ZNF766 VSIG10L SIGLEC8 RPL7P51 SIGLEC14 SIGLEC5 IGLON5 NKG7 ENSG00000267984 ENSG00000268520
GH19H051406 1.1 Ensembl ENCODE 11.3 -66.1 -66143 2 ATF1 RAD21 GATA2 ZNF143 FOS ATF7 RCOR1 SMARCA5 MIER2 REST CLDND2 NKG7 ETFB SIGLEC8 VSIG10L RPL7P51 SIGLEC14 SIGLEC5 FPR3 SIGLEC10
GH19H051338 1.1 ENCODE 10.2 +2.3 2339 2 HDGF PKNOX1 ARNT ARID4B SIN3A YY1 ZNF766 ZNF416 ZNF143 DEK ZNF841 ZNF616 ZNF577 ZNF766 ZNF350 ZNF836 POLD1 ZNF175 ZNF613 ZNF480
GH19H051292 0.5 ENCODE 16.8 +48.7 48654 1 NFIL3 POLR2A HLF ETS1 VSIG10L SIGLEC8 CTU1 RPL7P51 SIGLEC14 SIGLEC5 ENSG00000268595 LOC100420904 IGLON5
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around VSIG10L on UCSC Golden Path with GeneCards custom track

Genomic Location for VSIG10L Gene

Chromosome:
19
Start:
51,331,536 bp from pter
End:
51,342,124 bp from pter
Size:
10,589 bases
Orientation:
Minus strand

Genomic View for VSIG10L Gene

Genes around VSIG10L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
VSIG10L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for VSIG10L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VSIG10L Gene

Proteins for VSIG10L Gene

  • Protein details for VSIG10L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86VR7-VS10L_HUMAN
    Recommended name:
    V-set and immunoglobulin domain-containing protein 10-like
    Protein Accession:
    Q86VR7

    Protein attributes for VSIG10L Gene

    Size:
    867 amino acids
    Molecular mass:
    91625 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for VSIG10L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for VSIG10L Gene

Post-translational modifications for VSIG10L Gene

  • Glycosylation at Asn32, Asn88, posLast=9696, Asn144, posLast=423423, Asn487, Asn641, and Asn650
  • Modification sites at PhosphoSitePlus

Other Protein References for VSIG10L Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for VSIG10L Gene

Domains & Families for VSIG10L Gene

Gene Families for VSIG10L Gene

Protein Domains for VSIG10L Gene

Suggested Antigen Peptide Sequences for VSIG10L Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with VSIG10L: view

No data available for UniProtKB/Swiss-Prot for VSIG10L Gene

Function for VSIG10L Gene

Phenotypes From GWAS Catalog for VSIG10L Gene

Phenotypes for VSIG10L Gene

GenomeRNAi human phenotypes for VSIG10L:
genes like me logo Genes that share phenotypes with VSIG10L: view

Animal Model Products

  • Taconic Biosciences Mouse Models for VSIG10L

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for VSIG10L
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for VSIG10L Gene

Localization for VSIG10L Gene

Subcellular locations from UniProtKB/Swiss-Prot for VSIG10L Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for VSIG10L gene
Compartment Confidence
plasma membrane 3
extracellular 1
mitochondrion 1
peroxisome 1
nucleus 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for VSIG10L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with VSIG10L: view

Pathways & Interactions for VSIG10L Gene

SuperPathways for VSIG10L Gene

No Data Available

Interacting Proteins for VSIG10L Gene

Gene Ontology (GO) - Biological Process for VSIG10L Gene

None

No data available for Pathways by source and SIGNOR curated interactions for VSIG10L Gene

Drugs & Compounds for VSIG10L Gene

No Compound Related Data Available

Transcripts for VSIG10L Gene

mRNA/cDNA for VSIG10L Gene

Unigene Clusters for VSIG10L Gene

V-set and immunoglobulin domain containing 10 like:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for VSIG10L
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for VSIG10L Gene

No ASD Table

Relevant External Links for VSIG10L Gene

GeneLoc Exon Structure for
VSIG10L
ECgene alternative splicing isoforms for
VSIG10L

Expression for VSIG10L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for VSIG10L Gene

mRNA differential expression in normal tissues according to GTEx for VSIG10L Gene

This gene is overexpressed in Esophagus - Mucosa (x20.7), Vagina (x6.0), and Cervix - Ectocervix (x5.4).

Protein differential expression in normal tissues from HIPED for VSIG10L Gene

This gene is overexpressed in Saliva (39.3) and Esophagus (29.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for VSIG10L Gene



Protein tissue co-expression partners for VSIG10L Gene

NURSA nuclear receptor signaling pathways regulating expression of VSIG10L Gene:

VSIG10L

SOURCE GeneReport for Unigene cluster for VSIG10L Gene:

Hs.293236

Evidence on tissue expression from TISSUES for VSIG10L Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with VSIG10L: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for VSIG10L Gene

Orthologs for VSIG10L Gene

This gene was present in the common ancestor of chordates.

Orthologs for VSIG10L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia VSIG10L 33 34
  • 98.15 (n)
dog
(Canis familiaris)
Mammalia VSIG10L 33 34
  • 82.76 (n)
cow
(Bos Taurus)
Mammalia VSIG10L 33 34
  • 80.53 (n)
mouse
(Mus musculus)
Mammalia Vsig10l 33 16 34
  • 77.1 (n)
rat
(Rattus norvegicus)
Mammalia Vsig10l 33
  • 76.33 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia VSIG10L 34
  • 56 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia VSIG10L 34
  • 55 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia VSIG10L 34
  • 37 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii LOC100333975 33
  • 41.81 (n)
VSIG10L 34
  • 24 (a)
OneToOne
Species where no ortholog for VSIG10L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for VSIG10L Gene

ENSEMBL:
Gene Tree for VSIG10L (if available)
TreeFam:
Gene Tree for VSIG10L (if available)

Paralogs for VSIG10L Gene

Paralogs for VSIG10L Gene

genes like me logo Genes that share paralogs with VSIG10L: view

Variants for VSIG10L Gene

Sequence variations from dbSNP and Humsavar for VSIG10L Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000066887 -- 51,332,464(+) GTCCC(A/G)CTTTC utr-variant-3-prime
rs1000151973 -- 51,336,565(+) AGAAG(A/G)AGGAG intron-variant
rs1000458011 -- 51,339,923(+) TCCTC(C/T)TTGCT intron-variant
rs1000475999 -- 51,331,377(+) GAAGA(C/T)GTGAT downstream-variant-500B
rs1000488922 -- 51,339,532(+) TAAGA(A/C)AATTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for VSIG10L Gene

Variant ID Type Subtype PubMed ID
nsv1140251 OTHER inversion 24896259

Variation tolerance for VSIG10L Gene

Gene Damage Index Score: 3.84; 58.65% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for VSIG10L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
VSIG10L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VSIG10L Gene

Disorders for VSIG10L Gene

Relevant External Links for VSIG10L

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
VSIG10L

No disorders were found for VSIG10L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for VSIG10L Gene

Publications for VSIG10L Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 60
  2. Association Between Germline Mutation in VSIG10L and Familial Barrett Neoplasia. (PMID: 27467440) Fecteau RE … Chak A (JAMA oncology 2016) 3 60
  3. E-cadherin interactome complexity and robustness resolved by quantitative proteomics. (PMID: 25468996) Guo Z … Zaidel-Bar R (Science signaling 2014) 3 60
  4. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 4 60
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 60

Products for VSIG10L Gene

Sources for VSIG10L Gene

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