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Aliases for VSIG10 Gene

Aliases for VSIG10 Gene

  • V-Set And Immunoglobulin Domain Containing 10 2 3 5

External Ids for VSIG10 Gene

Previous GeneCards Identifiers for VSIG10 Gene

  • GC12M116987
  • GC12M118501
  • GC12M115511

Summaries for VSIG10 Gene

GeneCards Summary for VSIG10 Gene

VSIG10 (V-Set And Immunoglobulin Domain Containing 10) is a Protein Coding gene. An important paralog of this gene is VSIG10L.

Additional gene information for VSIG10 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VSIG10 Gene

Genomics for VSIG10 Gene

Regulatory Elements for VSIG10 Gene

Enhancers for VSIG10 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12H118058 1.6 FANTOM5 ENCODE dbSUPER 35.2 +74.1 74101 6 HDGF FOXA2 ARNT ARID4B SIN3A FEZF1 YY1 ZNF766 SMARCB1 ZNF592 VSIG10 RFC5 SUDS3 WSB2 PIR34670 GC12P118041
GH12H117968 1 ENCODE 18.4 +166.7 166738 1 PKNOX1 ARNT SIN3A FEZF1 ZNF2 BRCA1 GLIS2 ELK1 SP3 YY2 RFC5 SUDS3 VSIG10 ENSG00000256071 LINC02460 LINC02423 LINC02439 ENSG00000256149 KSR2
GH12H118119 1.2 Ensembl ENCODE 14.8 +14.9 14867 3 ELF3 FOXA2 RB1 ZBTB40 THRB RAD21 RARA ETS1 ZNF143 IKZF2 VSIG10 SUDS3 GC12M118121 GC12P118112
GH12H118134 1.1 ENCODE 14.3 -1.4 -1420 5 HDGF PKNOX1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 ZNF143 VSIG10 RFC5 WSB2 SUDS3 PEBP1 GC12M118176
GH12H118101 1 ENCODE 15 +32.7 32694 2 PKNOX1 ZFP64 ARID4B SIN3A YY1 GLIS2 FOS ZNF202 SP3 SP5 SUDS3 RFC5 VSIG10 FBXO21 GC12P118112 ENSG00000274859
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around VSIG10 on UCSC Golden Path with GeneCards custom track

Genomic Location for VSIG10 Gene

Chromosome:
12
Start:
118,063,593 bp from pter
End:
118,136,026 bp from pter
Size:
72,434 bases
Orientation:
Minus strand

Genomic View for VSIG10 Gene

Genes around VSIG10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
VSIG10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for VSIG10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VSIG10 Gene

Proteins for VSIG10 Gene

  • Protein details for VSIG10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N0Z9-VSI10_HUMAN
    Recommended name:
    V-set and immunoglobulin domain-containing protein 10
    Protein Accession:
    Q8N0Z9
    Secondary Accessions:
    • Q9NWQ7

    Protein attributes for VSIG10 Gene

    Size:
    540 amino acids
    Molecular mass:
    59217 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for VSIG10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for VSIG10 Gene

Post-translational modifications for VSIG10 Gene

  • Glycosylation at posLast=3939, posLast=4646, Asn70, posLast=108108, posLast=138138, Asn171, posLast=180180, Asn198, and posLast=326326
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for VSIG10 Gene

Domains & Families for VSIG10 Gene

Gene Families for VSIG10 Gene

Suggested Antigen Peptide Sequences for VSIG10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with VSIG10: view

No data available for UniProtKB/Swiss-Prot for VSIG10 Gene

Function for VSIG10 Gene

Phenotypes From GWAS Catalog for VSIG10 Gene

genes like me logo Genes that share phenotypes with VSIG10: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for VSIG10
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for VSIG10 Gene

Localization for VSIG10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for VSIG10 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for VSIG10 gene
Compartment Confidence
plasma membrane 3
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for VSIG10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with VSIG10: view

Pathways & Interactions for VSIG10 Gene

SuperPathways for VSIG10 Gene

No Data Available

Gene Ontology (GO) - Biological Process for VSIG10 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for VSIG10 Gene

Drugs & Compounds for VSIG10 Gene

No Compound Related Data Available

Transcripts for VSIG10 Gene

Unigene Clusters for VSIG10 Gene

V-set and immunoglobulin domain containing 10:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for VSIG10
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for VSIG10 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c · 3d ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
SP1:
SP2:
SP3: - - -
SP4: -
SP5: -
SP6:
SP7:

Relevant External Links for VSIG10 Gene

GeneLoc Exon Structure for
VSIG10
ECgene alternative splicing isoforms for
VSIG10

Expression for VSIG10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for VSIG10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for VSIG10 Gene

This gene is overexpressed in Placenta (35.5) and Spleen (33.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for VSIG10 Gene



Protein tissue co-expression partners for VSIG10 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of VSIG10 Gene:

VSIG10

SOURCE GeneReport for Unigene cluster for VSIG10 Gene:

Hs.187624

Evidence on tissue expression from TISSUES for VSIG10 Gene

  • Intestine(4.2)
genes like me logo Genes that share expression patterns with VSIG10: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for VSIG10 Gene

Orthologs for VSIG10 Gene

This gene was present in the common ancestor of chordates.

Orthologs for VSIG10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia VSIG10 33 34
  • 97.52 (n)
cow
(Bos Taurus)
Mammalia VSIG10 33 34
  • 84.05 (n)
dog
(Canis familiaris)
Mammalia VSIG10 33 34
  • 82.9 (n)
rat
(Rattus norvegicus)
Mammalia Vsig10 33
  • 75.95 (n)
mouse
(Mus musculus)
Mammalia Vsig10 33 16 34
  • 75.68 (n)
oppossum
(Monodelphis domestica)
Mammalia VSIG10 34
  • 59 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia VSIG10 34
  • 41 (a)
OneToOne
chicken
(Gallus gallus)
Aves VSIG10 34
  • 39 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia VSIG10 34
  • 36 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia vsig10 33
  • 50.53 (n)
zebrafish
(Danio rerio)
Actinopterygii vsig10 33 34
  • 45.42 (n)
Species where no ortholog for VSIG10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for VSIG10 Gene

ENSEMBL:
Gene Tree for VSIG10 (if available)
TreeFam:
Gene Tree for VSIG10 (if available)

Paralogs for VSIG10 Gene

Paralogs for VSIG10 Gene

genes like me logo Genes that share paralogs with VSIG10: view

Variants for VSIG10 Gene

Sequence variations from dbSNP and Humsavar for VSIG10 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000017240 -- 118,087,112(+) ACGGC(A/G)TTGGC intron-variant
rs1000168008 -- 118,071,680(+) AACAA(C/T)GGAAA intron-variant
rs1000189663 -- 118,094,994(+) CGCCT(C/T)CCAGG intron-variant
rs1000275903 -- 118,083,409(+) CATGT(C/T)TCTAC intron-variant, upstream-variant-2KB
rs1000310023 -- 118,089,783(+) TTCTG(A/T)TCCAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for VSIG10 Gene

Variant ID Type Subtype PubMed ID
esv2148077 CNV deletion 18987734
esv2746451 CNV deletion 23290073
esv2746453 CNV deletion 23290073
esv2746454 CNV deletion 23290073
esv3581916 CNV gain 25503493
nsv1124788 CNV deletion 24896259
nsv1144654 CNV deletion 24896259
nsv52642 CNV deletion 16902084
nsv53654 CNV deletion 16902084
nsv560389 CNV gain 21841781

Variation tolerance for VSIG10 Gene

Residual Variation Intolerance Score: 69.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.84; 94.81% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for VSIG10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
VSIG10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VSIG10 Gene

Disorders for VSIG10 Gene

Relevant External Links for VSIG10

Genetic Association Database (GAD)
VSIG10
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
VSIG10

No disorders were found for VSIG10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for VSIG10 Gene

Publications for VSIG10 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 60
  3. TAOK3, a novel genome-wide association study locus associated with morphine requirement and postoperative pain in a retrospective pediatric day surgery population. (PMID: 24909733) Cook-Sather SD … Hakonarson H (Pain 2014) 3 60
  4. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie AG … Butte NF (PloS one 2012) 3 60
  5. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K … Gorospe M (The EMBO journal 2009) 3 60

Products for VSIG10 Gene

Sources for VSIG10 Gene

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