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Aliases for VSIG10 Gene

Aliases for VSIG10 Gene

  • V-Set And Immunoglobulin Domain Containing 10 2 3 5

External Ids for VSIG10 Gene

Previous GeneCards Identifiers for VSIG10 Gene

  • GC12M116987
  • GC12M118501
  • GC12M115511

Summaries for VSIG10 Gene

GeneCards Summary for VSIG10 Gene

VSIG10 (V-Set And Immunoglobulin Domain Containing 10) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VSIG10 Gene

Genomics for VSIG10 Gene

Genomic Location for VSIG10 Gene

Chromosome:
12
Start:
118,063,593 bp from pter
End:
118,136,026 bp from pter
Size:
72,434 bases
Orientation:
Minus strand

Genomic View for VSIG10 Gene

Genes around VSIG10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
VSIG10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for VSIG10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VSIG10 Gene

No data available for Regulatory Elements for VSIG10 Gene

Proteins for VSIG10 Gene

  • Protein details for VSIG10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N0Z9-VSI10_HUMAN
    Recommended name:
    V-set and immunoglobulin domain-containing protein 10
    Protein Accession:
    Q8N0Z9
    Secondary Accessions:
    • Q9NWQ7

    Protein attributes for VSIG10 Gene

    Size:
    540 amino acids
    Molecular mass:
    59217 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for VSIG10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for VSIG10 Gene

Proteomics data for VSIG10 Gene at MOPED

Post-translational modifications for VSIG10 Gene

  • Glycosylation at Asn 39, Asn 46, Asn 70, Asn 108, Asn 138, Asn 171, Asn 180, Asn 198, and Asn 326
  • Modification sites at PhosphoSitePlus

Other Protein References for VSIG10 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for VSIG10 Gene

Domains & Families for VSIG10 Gene

Suggested Antigen Peptide Sequences for VSIG10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N0Z9

UniProtKB/Swiss-Prot:

VSI10_HUMAN :
  • Contains 4 Ig-like C2-type (immunoglobulin-like) domains.
Domain:
  • Contains 4 Ig-like C2-type (immunoglobulin-like) domains.
genes like me logo Genes that share domains with VSIG10: view

Function for VSIG10 Gene

genes like me logo Genes that share phenotypes with VSIG10: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for VSIG10 Gene

Localization for VSIG10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for VSIG10 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for VSIG10 Gene COMPARTMENTS Subcellular localization image for VSIG10 gene
Compartment Confidence
plasma membrane 3
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for VSIG10 Gene

Pathways & Interactions for VSIG10 Gene

SuperPathways for VSIG10 Gene

No Data Available

Interacting Proteins for VSIG10 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000352172%0d%0a9606.ENSP00000385269%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000352172 for VSIG10 Gene via STRING

Gene Ontology (GO) - Biological Process for VSIG10 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for VSIG10 Gene

Drugs & Compounds for VSIG10 Gene

No Compound Related Data Available

Transcripts for VSIG10 Gene

Unigene Clusters for VSIG10 Gene

V-set and immunoglobulin domain containing 10:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for VSIG10 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c · 3d ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
SP1:
SP2:
SP3: - - -
SP4: -
SP5: -
SP6:
SP7:

Relevant External Links for VSIG10 Gene

GeneLoc Exon Structure for
VSIG10
ECgene alternative splicing isoforms for
VSIG10

Expression for VSIG10 Gene

mRNA expression in normal human tissues for VSIG10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for VSIG10 Gene

This gene is overexpressed in Placenta (35.5) and Spleen (33.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for VSIG10 Gene



SOURCE GeneReport for Unigene cluster for VSIG10 Gene Hs.187624

genes like me logo Genes that share expression patterns with VSIG10: view

Protein tissue co-expression partners for VSIG10 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for VSIG10 Gene

Orthologs for VSIG10 Gene

This gene was present in the common ancestor of chordates.

Orthologs for VSIG10 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia VSIG10 35
  • 84.05 (n)
  • 77.28 (a)
VSIG10 36
  • 75 (a)
OneToOne
dog
(Canis familiaris)
Mammalia VSIG10 35
  • 82.9 (n)
  • 78.15 (a)
VSIG10 36
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Vsig10 35
  • 75.68 (n)
  • 69.71 (a)
Vsig10 16
Vsig10 36
  • 64 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia VSIG10 35
  • 97.52 (n)
  • 96.09 (a)
VSIG10 36
  • 95 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Vsig10 35
  • 75.95 (n)
  • 71.21 (a)
oppossum
(Monodelphis domestica)
Mammalia VSIG10 36
  • 59 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia VSIG10 36
  • 41 (a)
OneToOne
chicken
(Gallus gallus)
Aves VSIG10 36
  • 39 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia VSIG10 36
  • 36 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia vsig10 35
  • 50.53 (n)
  • 42.47 (a)
zebrafish
(Danio rerio)
Actinopterygii vsig10 35
  • 45.42 (n)
  • 34.36 (a)
vsig10 36
  • 29 (a)
OneToOne
Species with no ortholog for VSIG10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for VSIG10 Gene

ENSEMBL:
Gene Tree for VSIG10 (if available)
TreeFam:
Gene Tree for VSIG10 (if available)

Paralogs for VSIG10 Gene

No data available for Paralogs for VSIG10 Gene

Variants for VSIG10 Gene

Sequence variations from dbSNP and Humsavar for VSIG10 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs9668527 - 118,073,921(+) AGACA(C/T)CTGGC nc-transcript-variant, reference, missense
rs7307331 - 118,071,386(+) ATAAT(A/G)CAACA nc-transcript-variant, reference, missense
rs8239 -- 118,064,662(+) GCAAA(A/G)GACAA nc-transcript-variant, utr-variant-3-prime
rs1128304 -- 118,065,132(-) TAACA(C/G)TAAAT nc-transcript-variant, utr-variant-3-prime
rs1137584 -- 118,080,433(-) tctgt(A/G)atttc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for VSIG10 Gene

Variant ID Type Subtype PubMed ID
nsv899546 CNV Gain 21882294
esv2746451 CNV Deletion 23290073
esv2148077 CNV Deletion 18987734
nsv53654 CNV Loss 16902084
esv2746453 CNV Deletion 23290073
esv2746454 CNV Deletion 23290073
nsv52642 CNV Loss 16902084

Variation tolerance for VSIG10 Gene

Residual Variation Intolerance Score: 69.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.84; 94.81% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for VSIG10 Gene

HapMap Linkage Disequilibrium report
VSIG10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VSIG10 Gene

Disorders for VSIG10 Gene

Relevant External Links for VSIG10

Genetic Association Database (GAD)
VSIG10
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
VSIG10

No disorders were found for VSIG10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for VSIG10 Gene

Publications for VSIG10 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. TAOK3, a novel genome-wide association study locus associated with morphine requirement and postoperative pain in a retrospective pediatric day surgery population. (PMID: 24909733) Cook-Sather S.D. … Hakonarson H. (Pain 2014) 3
  4. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie A.G. … Butte N.F. (PLoS ONE 2012) 3
  5. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3

Products for VSIG10 Gene

Sources for VSIG10 Gene

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