Free for academic non-profit institutions. Other users need a Commercial license

Aliases for VSIG1 Gene

Aliases for VSIG1 Gene

  • V-Set And Immunoglobulin Domain Containing 1 2 3
  • Cell Surface A33 Antigen 3 4
  • Glycoprotein A34 3 4
  • GPA34 3 4
  • 1700062D20Rik 3
  • DJ889N15.1 3

External Ids for VSIG1 Gene

Previous GeneCards Identifiers for VSIG1 Gene

  • GC0XP107094
  • GC0XP107174
  • GC0XP107288
  • GC0XP096911

Summaries for VSIG1 Gene

Entrez Gene Summary for VSIG1 Gene

  • This gene encodes a member of the junctional adhesion molecule (JAM) family. The encoded protein contains multiple glycosylation sites at the N-terminal region, and multiple phosphorylation sites and glutamic acid/proline (EP) repeats at the C-terminal region. The gene is expressed in normal stomach and testis, as well as in gastric, esophageal and ovarian cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009]

GeneCards Summary for VSIG1 Gene

VSIG1 (V-Set And Immunoglobulin Domain Containing 1) is a Protein Coding gene. An important paralog of this gene is VSIG8.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VSIG1 Gene

Genomics for VSIG1 Gene

Regulatory Elements for VSIG1 Gene

Genomic Location for VSIG1 Gene

108,018,906 bp from pter
108,079,184 bp from pter
60,279 bases
Plus strand

Genomic View for VSIG1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for VSIG1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VSIG1 Gene

Proteins for VSIG1 Gene

  • Protein details for VSIG1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    V-set and immunoglobulin domain-containing protein 1
    Protein Accession:
    Secondary Accessions:
    • C9J4P2
    • Q6MZS4

    Protein attributes for VSIG1 Gene

    387 amino acids
    Molecular mass:
    41811 Da
    Quaternary structure:
    No Data Available
    • Sequence=CAE45954.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for VSIG1 Gene


neXtProt entry for VSIG1 Gene

Proteomics data for VSIG1 Gene at MOPED

Post-translational modifications for VSIG1 Gene

  • Highly N-glycosylated. Appears not to contain significant amounts of O-linked carbohydrates or sialic acid in its sugar moieties.
  • Glycosylation at Asn 32, Asn 38, Asn 133, Asn 200, and Asn 219
  • Modification sites at PhosphoSitePlus

Other Protein References for VSIG1 Gene

Antibody Products

No data available for DME Specific Peptides for VSIG1 Gene

Domains & Families for VSIG1 Gene

Protein Domains for VSIG1 Gene

Suggested Antigen Peptide Sequences for VSIG1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
genes like me logo Genes that share domains with VSIG1: view

Function for VSIG1 Gene

Gene Ontology (GO) - Molecular Function for VSIG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with VSIG1: view

Phenotypes for VSIG1 Gene

genes like me logo Genes that share phenotypes with VSIG1: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for VSIG1 Gene

Localization for VSIG1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for VSIG1 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for VSIG1 Gene COMPARTMENTS Subcellular localization image for VSIG1 gene
Compartment Confidence
plasma membrane 2

Gene Ontology (GO) - Cellular Components for VSIG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane --
GO:0016021 integral component of membrane IEA --
GO:0016323 basolateral plasma membrane IEA --
genes like me logo Genes that share ontologies with VSIG1: view

Pathways & Interactions for VSIG1 Gene

SuperPathways for VSIG1 Gene

No Data Available

Interacting Proteins for VSIG1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000402219 for VSIG1 Gene via STRING

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for VSIG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003382 epithelial cell morphogenesis IEA --
GO:0030277 maintenance of gastrointestinal epithelium IEA --
genes like me logo Genes that share ontologies with VSIG1: view

No data available for Pathways by source and SIGNOR curated interactions for VSIG1 Gene

Drugs & Compounds for VSIG1 Gene

No Compound Related Data Available

Transcripts for VSIG1 Gene

Unigene Clusters for VSIG1 Gene

V-set and immunoglobulin domain containing 1:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for VSIG1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for VSIG1 Gene

No ASD Table

Relevant External Links for VSIG1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for VSIG1 Gene

mRNA expression in normal human tissues for VSIG1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for VSIG1 Gene

This gene is overexpressed in Stomach (x34.7) and Testis (x11.6).

Protein differential expression in normal tissues from HIPED for VSIG1 Gene

This gene is overexpressed in Stomach (36.1), Testis (21.6), and Ovary (11.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for VSIG1 Gene

SOURCE GeneReport for Unigene cluster for VSIG1 Gene Hs.177164

mRNA Expression by UniProt/SwissProt for VSIG1 Gene

Tissue specificity: Detected only in stomach mucosa and testis, and to a much lesser level in pancreas (at protein level). Detected in gastric cancers (31%), esophageal carcinomas (50%) and ovarian cancers (23%).
genes like me logo Genes that share expression patterns with VSIG1: view

Protein tissue co-expression partners for VSIG1 Gene

Primer Products

In Situ Assay Products

Orthologs for VSIG1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for VSIG1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia VSIG1 35
  • 79.5 (n)
  • 71.93 (a)
VSIG1 36
  • 70 (a)
(Canis familiaris)
Mammalia VSIG1 35
  • 80.93 (n)
  • 75.67 (a)
VSIG1 36
  • 74 (a)
(Mus musculus)
Mammalia Vsig1 35
  • 75.76 (n)
  • 72.21 (a)
Vsig1 36
  • 68 (a)
(Pan troglodytes)
Mammalia VSIG1 35
  • 99.66 (n)
  • 98.97 (a)
VSIG1 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Vsig1 35
  • 78.47 (n)
  • 73.96 (a)
(Monodelphis domestica)
Mammalia VSIG1 36
  • 57 (a)
(Gallus gallus)
Aves VSIG1 35
  • 57.48 (n)
  • 48.3 (a)
VSIG1 36
  • 43 (a)
(Anolis carolinensis)
Reptilia VSIG1 36
  • 38 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia vsig1 35
  • 52.65 (n)
  • 45.31 (a)
(Danio rerio)
Actinopterygii zgc:165604 36
  • 27 (a)
Species with no ortholog for VSIG1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for VSIG1 Gene

Gene Tree for VSIG1 (if available)
Gene Tree for VSIG1 (if available)

Paralogs for VSIG1 Gene

Paralogs for VSIG1 Gene

(2) SIMAP similar genes for VSIG1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with VSIG1: view

Variants for VSIG1 Gene

Sequence variations from dbSNP and Humsavar for VSIG1 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs699665 -- 108,070,920(+) TGAGC(A/G)GAAGT intron-variant
rs699666 -- 108,068,101(+) ATACC(C/T)AAGAG intron-variant
rs699667 -- 108,067,375(-) GTTGG(A/C/G)TCATC intron-variant
rs699668 -- 108,067,159(-) AAAAG(A/G)AAAAG intron-variant
rs807161 -- 108,073,765(+) AGTAT(C/T)ATAAT intron-variant

Variation tolerance for VSIG1 Gene

Residual Variation Intolerance Score: 32.99% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.97; 19.99% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for VSIG1 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for VSIG1 Gene

Disorders for VSIG1 Gene

Relevant External Links for VSIG1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with VSIG1: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for VSIG1 Gene

Publications for VSIG1 Gene

  1. Glycoprotein A34, a novel target for antibody-based cancer immunotherapy. (PMID: 16405301) Scanlan M.J. … Jungbluth A.A. (Cancer Immun. 2006) 23 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 67
  3. Decreased expression of V-set and immunoglobulin domain containing 1 (VSIG1) is associated with poor prognosis in primary gastric cancer. (PMID: 22095633) Chen Y. … Li Q. (J Surg Oncol 2012) 67
  4. The full-ORF clone resource of the German cDNA consortium. (PMID: 17974005) Bechtel S. … Schupp I. (BMC Genomics 2007) 67
  5. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 67

Products for VSIG1 Gene

Sources for VSIG1 Gene

Back to Top