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Aliases for VRTN Gene

Aliases for VRTN Gene

  • Vertebrae Development Associated 2 3 5
  • Vertebrae Development Homolog (Pig) 2 3
  • C14orf115 3 4
  • Chromosome 14 Open Reading Frame 115 2
  • Vertnin 3

External Ids for VRTN Gene

Previous HGNC Symbols for VRTN Gene

  • C14orf115

Previous GeneCards Identifiers for VRTN Gene

  • GC14P074817

Summaries for VRTN Gene

GeneCards Summary for VRTN Gene

VRTN (Vertebrae Development Associated) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding and transposase activity.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VRTN Gene

Genomics for VRTN Gene

Regulatory Elements for VRTN Gene

Enhancers for VRTN Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14G074400 1.5 FANTOM5 Ensembl ENCODE dbSUPER 3.5 +98.7 98739 3.2 BCOR CTCF PKNOX1 ZMYM3 EBF1 POLR2A ADNP TCF7L2 MAZ MTA2 SYNDIG1L ENSG00000259005 ENSG00000270000 VRTN ABCD4 GC14M074406 RPS2P2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around VRTN on UCSC Golden Path with GeneCards custom track

Promoters for VRTN Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000070716 -576 1801 FOXA2 CREB3L1 ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3

Genomic Location for VRTN Gene

Chromosome:
14
Start:
74,303,069 bp from pter
End:
74,360,008 bp from pter
Size:
56,940 bases
Orientation:
Plus strand

Genomic View for VRTN Gene

Genes around VRTN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
VRTN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for VRTN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VRTN Gene

Proteins for VRTN Gene

  • Protein details for VRTN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H8Y1-VRTN_HUMAN
    Recommended name:
    Vertnin
    Protein Accession:
    Q9H8Y1
    Secondary Accessions:
    • Q9NVC7

    Protein attributes for VRTN Gene

    Size:
    702 amino acids
    Molecular mass:
    78260 Da
    Quaternary structure:
    No Data Available

neXtProt entry for VRTN Gene

Post-translational modifications for VRTN Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for VRTN Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for VRTN Gene

Domains & Families for VRTN Gene

Suggested Antigen Peptide Sequences for VRTN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H8Y1

UniProtKB/Swiss-Prot:

VRTN_HUMAN :
  • Belongs to the vertnin family.
Family:
  • Belongs to the vertnin family.
genes like me logo Genes that share domains with VRTN: view

No data available for Gene Families for VRTN Gene

Function for VRTN Gene

Gene Ontology (GO) - Molecular Function for VRTN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004803 transposase activity IEA --
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with VRTN: view
genes like me logo Genes that share phenotypes with VRTN: view

Animal Model Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for VRTN Gene

Localization for VRTN Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for VRTN gene
Compartment Confidence
nucleus 3
cytosol 2
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for VRTN Gene

Pathways & Interactions for VRTN Gene

No Data Available

Interacting Proteins for VRTN Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000256362%0d%0a9606.ENSP00000229307%0d%0a
Selected Interacting proteins: Q9H8Y1-VRTN_HUMAN ENSP00000256362 for VRTN Gene via IID STRING

Gene Ontology (GO) - Biological Process for VRTN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006313 transposition, DNA-mediated IEA --
genes like me logo Genes that share ontologies with VRTN: view

No data available for Pathways by source and SIGNOR curated interactions for VRTN Gene

Drugs & Compounds for VRTN Gene

No Compound Related Data Available

Transcripts for VRTN Gene

mRNA/cDNA for VRTN Gene

(2) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(15) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for VRTN Gene

Vertebrae development associated:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for VRTN Gene

No ASD Table

Relevant External Links for VRTN Gene

GeneLoc Exon Structure for
VRTN
ECgene alternative splicing isoforms for
VRTN

Expression for VRTN Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for VRTN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for VRTN Gene

This gene is overexpressed in Testis (x38.5).

NURSA nuclear receptor signaling pathways regulating expression of VRTN Gene:

VRTN

SOURCE GeneReport for Unigene cluster for VRTN Gene:

Hs.578167
genes like me logo Genes that share expression patterns with VRTN: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for VRTN Gene

Orthologs for VRTN Gene

This gene was present in the common ancestor of chordates.

Orthologs for VRTN Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC101057922 34
  • 98.86 (n)
dog
(Canis familiaris)
Mammalia VRTN 34 35
  • 84.74 (n)
cow
(Bos Taurus)
Mammalia VRTN 34 35
  • 84.25 (n)
rat
(Rattus norvegicus)
Mammalia Vrtn 34
  • 81.13 (n)
mouse
(Mus musculus)
Mammalia Vrtn 34 16 35
  • 79.05 (n)
oppossum
(Monodelphis domestica)
Mammalia VRTN 35
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves VRTN 34 35
  • 66.62 (n)
lizard
(Anolis carolinensis)
Reptilia VRTN 35
  • 53 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii vrtn 34 35
  • 53.85 (n)
Species where no ortholog for VRTN was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for VRTN Gene

ENSEMBL:
Gene Tree for VRTN (if available)
TreeFam:
Gene Tree for VRTN (if available)

Paralogs for VRTN Gene

No data available for Paralogs for VRTN Gene

Variants for VRTN Gene

Sequence variations from dbSNP and Humsavar for VRTN Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs773509797 A colorectal cancer sample 74,357,180(+) AGGCC(A/G/T)TGCGC reference, missense
rs1000075418 -- 74,340,282(+) TAATT(C/T)TGTAT intron-variant
rs1000137388 -- 74,333,790(+) AGCCA(A/G)GATCG intron-variant
rs1000145514 -- 74,339,087(+) TTGAA(C/T)CCCTG intron-variant
rs1000156160 -- 74,337,357(+) AAAAC(-/A)AACAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for VRTN Gene

Variant ID Type Subtype PubMed ID
nsv1113663 CNV deletion 24896259
nsv1122913 CNV deletion 24896259
nsv565184 CNV loss 21841781

Variation tolerance for VRTN Gene

Residual Variation Intolerance Score: 32.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.12; 38.63% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for VRTN Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
VRTN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VRTN Gene

Disorders for VRTN Gene

Relevant External Links for VRTN

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
VRTN

No disorders were found for VRTN Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for VRTN Gene

Publications for VRTN Gene

  1. Identification of a second gene associated with variation in vertebral number in domestic pigs. (PMID: 21232157) Mikawa S. … Awata T. (BMC Genet. 2011) 2 3 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. The variant Polycomb Repressor Complex 1 component PCGF1 interacts with a pluripotency sub-network that includes DPPA4, a regulator of embryogenesis. (PMID: 26687479) Oliviero G. … Cagney G. (Sci. Rep. 2015) 3 64
  5. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PMID: 21406692) Rigbolt K.T. … Blagoev B. (Sci. Signal. 2011) 4 64

Products for VRTN Gene

Sources for VRTN Gene

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