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Aliases for VRTN Gene

Aliases for VRTN Gene

  • Vertebrae Development Associated 2 3 5
  • Vertebrae Development Homolog (Pig) 2 3
  • C14orf115 3 4
  • Chromosome 14 Open Reading Frame 115 2
  • Vertnin 3

External Ids for VRTN Gene

Previous HGNC Symbols for VRTN Gene

  • C14orf115

Previous GeneCards Identifiers for VRTN Gene

  • GC14P074817

Summaries for VRTN Gene

GeneCards Summary for VRTN Gene

VRTN (Vertebrae Development Associated) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding and transposase activity.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VRTN Gene

Genomics for VRTN Gene

Regulatory Elements for VRTN Gene

Enhancers for VRTN Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around VRTN on UCSC Golden Path with GeneCards custom track

Promoters for VRTN Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around VRTN on UCSC Golden Path with GeneCards custom track

Genomic Location for VRTN Gene

Chromosome:
14
Start:
74,303,069 bp from pter
End:
74,360,008 bp from pter
Size:
56,940 bases
Orientation:
Plus strand

Genomic View for VRTN Gene

Genes around VRTN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
VRTN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for VRTN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VRTN Gene

Proteins for VRTN Gene

  • Protein details for VRTN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H8Y1-VRTN_HUMAN
    Recommended name:
    Vertnin
    Protein Accession:
    Q9H8Y1
    Secondary Accessions:
    • Q9NVC7

    Protein attributes for VRTN Gene

    Size:
    702 amino acids
    Molecular mass:
    78260 Da
    Quaternary structure:
    No Data Available

neXtProt entry for VRTN Gene

Proteomics data for VRTN Gene at MOPED

Post-translational modifications for VRTN Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for VRTN Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for VRTN Gene

Domains & Families for VRTN Gene

Protein Domains for VRTN Gene

Suggested Antigen Peptide Sequences for VRTN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H8Y1

UniProtKB/Swiss-Prot:

VRTN_HUMAN :
  • Belongs to the vertnin family.
Family:
  • Belongs to the vertnin family.
genes like me logo Genes that share domains with VRTN: view

No data available for Gene Families for VRTN Gene

Function for VRTN Gene

Gene Ontology (GO) - Molecular Function for VRTN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004803 transposase activity IEA --
genes like me logo Genes that share ontologies with VRTN: view
genes like me logo Genes that share phenotypes with VRTN: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for VRTN Gene

Localization for VRTN Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for VRTN Gene COMPARTMENTS Subcellular localization image for VRTN gene
Compartment Confidence
nucleus 3
cytosol 2
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for VRTN Gene

Pathways & Interactions for VRTN Gene

SuperPathways for VRTN Gene

No Data Available

Interacting Proteins for VRTN Gene

Selected Interacting proteins: Q9H8Y1-VRTN_HUMAN for VRTN Gene via I2D

Symbol External ID(s) Details
SALL4

Gene Ontology (GO) - Biological Process for VRTN Gene

None

No data available for Pathways by source and SIGNOR curated interactions for VRTN Gene

Drugs & Compounds for VRTN Gene

No Compound Related Data Available

Transcripts for VRTN Gene

mRNA/cDNA for VRTN Gene

(5) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(15) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for VRTN Gene

Vertebrae development associated:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for VRTN Gene

No ASD Table

Relevant External Links for VRTN Gene

GeneLoc Exon Structure for
VRTN
ECgene alternative splicing isoforms for
VRTN

Expression for VRTN Gene

mRNA expression in normal human tissues for VRTN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for VRTN Gene

This gene is overexpressed in Testis (x38.5).

SOURCE GeneReport for Unigene cluster for VRTN Gene Hs.578167

genes like me logo Genes that share expression patterns with VRTN: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for VRTN Gene

Orthologs for VRTN Gene

This gene was present in the common ancestor of chordates.

Orthologs for VRTN Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia VRTN 35
  • 84.25 (n)
  • 84.74 (a)
VRTN 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia VRTN 35
  • 84.74 (n)
  • 83.53 (a)
VRTN 36
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Vrtn 35
  • 79.05 (n)
  • 75.43 (a)
Vrtn 16
Vrtn 36
  • 70 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LOC101057922 35
  • 98.86 (n)
  • 98.16 (a)
rat
(Rattus norvegicus)
Mammalia Vrtn 35
  • 81.13 (n)
  • 78.6 (a)
oppossum
(Monodelphis domestica)
Mammalia VRTN 36
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves VRTN 35
  • 66.62 (n)
  • 60.24 (a)
VRTN 36
  • 57 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia VRTN 36
  • 53 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii vrtn 35
  • 53.85 (n)
  • 47.69 (a)
vrtn 36
  • 44 (a)
OneToOne
Species with no ortholog for VRTN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for VRTN Gene

ENSEMBL:
Gene Tree for VRTN (if available)
TreeFam:
Gene Tree for VRTN (if available)

Paralogs for VRTN Gene

No data available for Paralogs for VRTN Gene

Variants for VRTN Gene

Sequence variations from dbSNP and Humsavar for VRTN Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
VAR_035677 A colorectal cancer sample
rs2232032 - 74,356,940(+) CTGGC(C/T)TCCAG reference, missense
rs7401357 -- 74,339,842(+) GGAGA(A/C)CATGT intron-variant
rs1548682 -- 74,306,170(-) AAATA(A/T)ATATA intron-variant
rs1548683 -- 74,306,168(-) atata(A/C/T)atata intron-variant

Structural Variations from Database of Genomic Variants (DGV) for VRTN Gene

Variant ID Type Subtype PubMed ID
nsv902096 CNV Gain 21882294

Variation tolerance for VRTN Gene

Residual Variation Intolerance Score: 32.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.12; 38.63% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for VRTN Gene

Disorders for VRTN Gene

Relevant External Links for VRTN

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
VRTN

No disorders were found for VRTN Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for VRTN Gene

Publications for VRTN Gene

  1. Identification of a second gene associated with variation in vertebral number in domestic pigs. (PMID: 21232157) Mikawa S. … Awata T. (BMC Genet. 2011) 2 3 67
  2. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for VRTN Gene

Sources for VRTN Gene

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