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Aliases for VRK3 Gene

Aliases for VRK3 Gene

  • Vaccinia Related Kinase 3 2 3
  • Serine/Threonine-Protein Pseudokinase VRK3 4
  • Vaccinia-Related Kinase 3 4

External Ids for VRK3 Gene

Summaries for VRK3 Gene

Entrez Gene Summary for VRK3 Gene

  • This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. In both human and mouse, this gene has substitutions at several residues within the ATP binding motifs that in other kinases have been shown to be required for catalysis. In vitro assays indicate the protein lacks phosphorylation activity. The protein, however, likely retains its substrate binding capability. This gene is widely expressed in human tissues and its protein localizes to the nucleus. Alternative splicing results in multiple transcripts encoding different isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for VRK3 Gene

VRK3 (Vaccinia Related Kinase 3) is a Protein Coding gene. Diseases associated with VRK3 include vaccinia. Among its related pathways are Cell Cycle / Checkpoint Control and MAPK targets/ Nuclear events mediated by MAP kinases. GO annotations related to this gene include protein kinase activity and protein phosphatase binding. An important paralog of this gene is CSNK1G2.

UniProtKB/Swiss-Prot for VRK3 Gene

  • Inactive kinase that suppresses ERK activity by promoting phosphatase activity of DUSP3 which specifically dephosphorylates and inactivates ERK in the nucleus.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VRK3 Gene

Genomics for VRK3 Gene

Genomic Location for VRK3 Gene

Start:
49,976,467 bp from pter
End:
50,026,017 bp from pter
Size:
49,551 bases
Orientation:
Minus strand

Genomic View for VRK3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for VRK3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VRK3 Gene

Regulatory Elements for VRK3 Gene

Proteins for VRK3 Gene

  • Protein details for VRK3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IV63-VRK3_HUMAN
    Recommended name:
    Inactive serine/threonine-protein kinase VRK3
    Protein Accession:
    Q8IV63
    Secondary Accessions:
    • A6NEG5
    • A8KA53
    • Q502Y2
    • Q9P2V8

    Protein attributes for VRK3 Gene

    Size:
    474 amino acids
    Molecular mass:
    52881 Da
    Quaternary structure:
    • Interacts with DUSP3 (By similarity). Interacts with RAN.

    Three dimensional structures from OCA and Proteopedia for VRK3 Gene

    Alternative splice isoforms for VRK3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for VRK3 Gene

Proteomics data for VRK3 Gene at MOPED

Post-translational modifications for VRK3 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys275

No data available for DME Specific Peptides for VRK3 Gene

Domains for VRK3 Gene

Gene Families for VRK3 Gene

Protein Domains for VRK3 Gene

UniProtKB/Swiss-Prot:

VRK3_HUMAN
Domain:
  • Contains 1 protein kinase domain.:
    • Q8IV63
Family:
  • Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. VRK subfamily.:
    • Q8IV63
genes like me logo Genes that share domains with VRK3: view

Function for VRK3 Gene

Molecular function for VRK3 Gene

UniProtKB/Swiss-Prot Function: Inactive kinase that suppresses ERK activity by promoting phosphatase activity of DUSP3 which specifically dephosphorylates and inactivates ERK in the nucleus.

Gene Ontology (GO) - Molecular Function for VRK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity IBA --
GO:0005524 ATP binding IEA --
GO:0016772 transferase activity, transferring phosphorus-containing groups --
GO:0019903 protein phosphatase binding IDA 22572157
genes like me logo Genes that share ontologies with VRK3: view

Phenotypes for VRK3 Gene

GenomeRNAi human phenotypes for VRK3:
genes like me logo Genes that share phenotypes with VRK3: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for VRK3 Gene

Localization for VRK3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for VRK3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for VRK3 Gene COMPARTMENTS Subcellular localization image for VRK3 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for VRK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with VRK3: view

Pathways for VRK3 Gene

genes like me logo Genes that share pathways with VRK3: view

Pathways by source for VRK3 Gene

1 GeneGo (Thomson Reuters Life Sciences Research) pathway for VRK3 Gene
2 Cell Signaling Technology pathways for VRK3 Gene

Gene Ontology (GO) - Biological Process for VRK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation --
GO:0006897 endocytosis IBA --
GO:0008360 regulation of cell shape IBA --
GO:0016055 Wnt signaling pathway IBA --
GO:0018105 peptidyl-serine phosphorylation IBA --
genes like me logo Genes that share ontologies with VRK3: view

Compounds for VRK3 Gene

(2) HMDB Compounds for VRK3 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
genes like me logo Genes that share compounds with VRK3: view

Transcripts for VRK3 Gene

Unigene Clusters for VRK3 Gene

Vaccinia related kinase 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for VRK3 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^
SP1: - - - - -
SP2: - - -
SP3: - - -
SP4: - - -
SP5: - -
SP6: - - - -
SP7: - - - - -
SP8: - - - -
SP9: - - - - -
SP10: - -
SP11: -
SP12: - -
SP13: - - - - - - -
SP14:
SP15:

ExUns: 18 ^ 19a · 19b ^ 20a · 20b ^ 21a · 21b
SP1: - -
SP2: - -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:

Relevant External Links for VRK3 Gene

GeneLoc Exon Structure for
VRK3
ECgene alternative splicing isoforms for
VRK3

Expression for VRK3 Gene

mRNA expression in normal human tissues for VRK3 Gene

mRNA differential expression in normal tissues according to GTEx for VRK3 Gene

This gene is overexpressed in Testis (5.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for VRK3 Gene

SOURCE GeneReport for Unigene cluster for VRK3 Gene Hs.443330

genes like me logo Genes that share expressions with VRK3: view

Orthologs for VRK3 Gene

This gene was present in the common ancestor of animals.

Orthologs for VRK3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia VRK3 36
  • 98.87 (n)
  • 97.89 (a)
VRK3 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia VRK3 36
  • 83.56 (n)
  • 76.67 (a)
VRK3 37
  • 77 (a)
OneToOne
dog
(Canis familiaris)
Mammalia VRK3 36
  • 83.81 (n)
  • 78.87 (a)
VRK3 37
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Vrk3 36
  • 81.53 (n)
  • 75.28 (a)
Vrk3 16
Vrk3 37
  • 75 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia VRK3 37
  • 46 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 11 (a)
ManyToMany
-- 37
  • 19 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Vrk3 36
  • 81.09 (n)
  • 75.5 (a)
chicken
(Gallus gallus)
Aves VRK3 37
  • 45 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia VRK3 37
  • 60 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.25500 36
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.7094 36
vrk3 36
  • 51.92 (n)
  • 48.58 (a)
zebrafish
(Danio rerio)
Actinopterygii vrk3 36
  • 50.83 (n)
  • 46.06 (a)
vrk3 37
  • 36 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta ball 37
  • 16 (a)
ManyToMany
CG8878 37
  • 11 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea vrk-1 37
  • 12 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6830 37
  • 32 (a)
OneToMany
Species with no ortholog for VRK3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for VRK3 Gene

ENSEMBL:
Gene Tree for VRK3 (if available)
TreeFam:
Gene Tree for VRK3 (if available)

Paralogs for VRK3 Gene

genes like me logo Genes that share paralogs with VRK3: view

Variants for VRK3 Gene

Sequence variations from dbSNP and Humsavar for VRK3 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs15913 -- 49,980,965(+) GGCCT(G/T)ATCCA synonymous-codon, reference, nc-transcript-variant
rs15983 -- 49,979,223(+) ACCTT(C/G/T)AGGTA synonymous-codon, reference, nc-transcript-variant
rs157546 -- 50,021,869(+) ctaca(A/G)aacct intron-variant
rs157547 -- 49,991,825(+) gtgcc(C/T)gagac intron-variant
rs181743 -- 50,019,139(+) cggcc(G/T)gggag intron-variant

Structural Variations from Database of Genomic Variants (DGV) for VRK3 Gene

Variant ID Type Subtype PubMed ID
nsv9739 CNV Gain+Loss 18304495
dgv54n68 CNV Loss 17160897
esv2751796 CNV Gain 17911159
esv29129 CNV Loss 19812545
nsv819518 CNV Gain 19587683
nsv458722 CNV Gain 19166990

Relevant External Links for VRK3 Gene

HapMap Linkage Disequilibrium report
VRK3

Disorders for VRK3 Gene

(1) MalaCards Diseases for VRK3 Gene

Search for VRK3 Gene in MalaCards »

(1) University of Copenhagen DISEASES for VRK3 Gene

Relevant External Links for VRK3

Genetic Association Database (GAD)
VRK3
Human Genome Epidemiology (HuGE) Navigator
VRK3
genes like me logo Genes that share disorders with VRK3: view

No data available for UniProtKB/Swiss-Prot for VRK3 Gene

Publications for VRK3 Gene

  1. Characterization of three paralogous members of the Mammalian vaccinia related kinase family. (PMID: 14645249) Nichols R.J. … Traktman P. (J. Biol. Chem. 2004) 3 4 23
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Proteomics identification of nuclear Ran GTPase as an inhibitor of human VRK1 and VRK2 (vaccinia-related kinase) activities. (PMID: 18617507) Sanz-Garcia M. … Lazo P.A. (Mol. Cell. Proteomics 2008) 3 4
  4. Proteomic characterization of the human sperm nucleus. (PMID: 21630459) de Mateo S. … Oliva R. (Proteomics 2011) 3
  5. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PMID: 21890473) Wagner S.A. … Choudhary C. (Mol. Cell Proteomics 2011) 3

Products for VRK3 Gene

  • Addgene plasmids for VRK3

Sources for VRK3 Gene

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