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VRK3 Gene

protein-coding   GIFtS: 59
GCID: GC19M050479

Vaccinia Related Kinase 3

  See VRK3-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Vaccinia Related Kinase 31 2
Serine/Threonine-Protein Pseudokinase VRK32 3
Vaccinia-Related Kinase 32 3
Inactive Serine/Threonine-Protein Kinase VRK32
Serine/Threonine-Protein Kinase VRK32

External Ids:    HGNC: 189961   Entrez Gene: 512312   Ensembl: ENSG000001050537   UniProtKB: Q8IV633   

Export aliases for VRK3 gene to outside databases

Previous GC identifers: GC19M055155 GC19M055171 GC19M046855


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for VRK3 Gene:
This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. In
both human and mouse, this gene has substitutions at several residues within the ATP binding motifs that in other
kinases have been shown to be required for catalysis. In vitro assays indicate the protein lacks phosphorylation
activity. The protein, however, likely retains its substrate binding capability. This gene is widely expressed in
human tissues and its protein localizes to the nucleus. Alternative splicing results in multiple transcripts
encoding different isoforms. (provided by RefSeq, Jul 2008)

GeneCards Summary for VRK3 Gene:
VRK3 (vaccinia related kinase 3) is a protein-coding gene. Diseases associated with VRK3 include vaccinia. GO annotations related to this gene include protein phosphatase binding and protein kinase activity. An important paralog of this gene is VRK1.

UniProtKB/Swiss-Prot: VRK3_HUMAN, Q8IV63
Function: Inactive kinase that suppresses ERK activity by promoting phosphatase activity of DUSP3 which
specifically dephosphorylates and inactivates ERK in the nucleus (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NT_011109.17  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the VRK3 gene promoter:
         STAT5B   NCX/Ncx   Bach2   STAT5A   AREB6   E2F-1   E2F   Msx-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidVRK3 promoter sequence
   Search Chromatin IP Primers for VRK3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat VRK3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13   Ensembl cytogenetic band:  19q13.33   HGNC cytogenetic band: 19q13.33

VRK3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
VRK3 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M050479:  view genomic region     (about GC identifiers)

Start:
50,479,724 bp from pter      End:
50,529,203 bp from pter
Size:
49,480 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: VRK3_HUMAN, Q8IV63 (See protein sequence)
Recommended Name: Inactive serine/threonine-protein kinase VRK3  
Size: 474 amino acids; 52881 Da
Subunit: Interacts with DUSP3 (By similarity). Interacts with RAN
Caution: Inactive as a kinase due to its inability to bind ATP (PubMed:19141289)
1 PDB 3D structure from and Proteopedia for VRK3:
2JII (3D)    
Secondary accessions: A6NEG5 A8KA53 Q502Y2 Q9P2V8
Alternative splicing: 3 isoforms:  Q8IV63-1   Q8IV63-2   Q8IV63-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for VRK3: NX_Q8IV63

Explore proteomics data for VRK3 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys275
  • Modification sites at PhosphoSitePlus

  • See VRK3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001020949.1  NP_057524.3  

    ENSEMBL proteins: 
     ENSP00000324636   ENSP00000366210   ENSP00000469880   ENSP00000472217   ENSP00000470156  
     ENSP00000473171   ENSP00000471061   ENSP00000472541   ENSP00000473222   ENSP00000469710  
     ENSP00000469325   ENSP00000469802   ENSP00000471661   ENSP00000468979   ENSP00000470940  
     ENSP00000469400   ENSP00000469092   ENSP00000470359   ENSP00000414907  

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    ProSpec Recombinant Protein for VRK3
    Cloud-Clone Corp. Proteins for VRK3

     
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    antibodies-online proteins for VRK3 (11 products) 

     
    antibodies-online peptides for VRK3

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: vaccinia related kinase 3
    Vaccina related kinase (VRK) family

    3 InterPro protein domains:
     IPR011009 Kinase-like_dom
     IPR000719 Prot_kinase_dom
     IPR026870 Zinc_ribbon_dom

    Graphical View of Domain Structure for InterPro Entry Q8IV63

    ProtoNet protein and cluster: Q8IV63

    UniProtKB/Swiss-Prot: VRK3_HUMAN, Q8IV63
    Similarity: Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. VRK subfamily
    Similarity: Contains 1 protein kinase domain


    Find genes that share domains with VRK3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: VRK3_HUMAN, Q8IV63
    Function: Inactive kinase that suppresses ERK activity by promoting phosphatase activity of DUSP3 which
    specifically dephosphorylates and inactivates ERK in the nucleus (By similarity)

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity IEA--
    GO:0005524ATP binding IEA--
    GO:0016772transferase activity, transferring phosphorus-containing groups ----
    GO:0019903protein phosphatase binding IEA--
         
    Find genes that share ontologies with VRK3           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for VRK3:
     Decreased mitotic index 

         1 MGI phenotypic allele for Vrk3 (no phenotypes)

    Find genes that share phenotypes with VRK3           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for VRK3

    miRNA
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    6 qRT-PCR Assays for microRNAs that regulate VRK3:
    hsa-miR-214 hsa-miR-23b hsa-miR-130a* hsa-miR-23a hsa-miR-23c hsa-miR-761
    SwitchGear 3'UTR luciferase reporter plasmidVRK3 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat VRK3

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 2): VRK3 (NM_001025778)
    Sino Biological Human cDNA Clone for VRK3
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for VRK3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VRK3
    Addgene plasmids for VRK3 

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    VRK3_HUMAN, Q8IV63: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    Find genes that share ontologies with VRK3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for VRK3 About    
    See pathways by source

    SuperPathContained pathways About
    1Cell Cycle / Checkpoint Control
    Cell Cycle / Checkpoint Control0.32
    2MAPK targets/ Nuclear events mediated by MAP kinases
    MAP Kinase Signaling0.31
    3Signal transduction Erk Interactions Inhibition of Erk
    Signal transduction Erk Interactions Inhibition of Erk


    Find genes that share SuperPaths with VRK3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Cell Signaling Technology (CST) Pathways for VRK3
        MAP Kinase Signaling
    Cell Cycle / Checkpoint Control

    1 GeneGo (Thomson Reuters) Pathway for VRK3
        Signal transduction Erk Interactions- Inhibition of Erk



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for VRK3
    Interactions:

        Search GeneGlobe Interaction Network for VRK3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for VRK3 (Q8IV632, 3 ENSP000003246364) via UniProtKB, MINT, STRING, and/or I2D (see all 45)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CSNK2BP678702, 3MINT-8253781 I2D: score=2 
    ENSG00000206406P678702, 3MINT-8253781 I2D: score=2 
    ENSG00000224398P678702, 3MINT-8253781 I2D: score=2 
    ENSG00000224774P678702, 3MINT-8253781 I2D: score=2 
    ENSG00000228875P678702, 3MINT-8253781 I2D: score=2 
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation ----
    GO:0032516positive regulation of phosphoprotein phosphatase activity IEA--
    GO:0070373negative regulation of ERK1 and ERK2 cascade IEA--

    Find genes that share ontologies with VRK3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for VRK3

    2 HMDB Compounds for VRK3    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for VRK3 gene (2 alternative transcripts): 
    NM_001025778.1  NM_016440.3  

    Unigene Cluster for VRK3:

    Vaccinia related kinase 3
    Hs.443330  [show with all ESTs]
    Unigene Representative Sequence: AK123892
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 27):
    ENST00000316763(uc002prg.2 uc002prh.1 uc002prk.2 uc010ent.2 uc002prl.3 uc010ybn.1)
    ENST00000377011(uc002pri.1) ENST00000599538 ENST00000596814 ENST00000601341
    ENST00000594948 ENST00000598553 ENST00000601912 ENST00000594092 ENST00000593912
    ENST00000600284 ENST00000593919 ENST00000594090 ENST00000596121 ENST00000424804
    ENST00000599342 ENST00000600137 ENST00000594104
    miRNA
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    6 qRT-PCR Assays for microRNAs that regulate VRK3:
    hsa-miR-214 hsa-miR-23b hsa-miR-130a* hsa-miR-23a hsa-miR-23c hsa-miR-761
    SwitchGear 3'UTR luciferase reporter plasmidVRK3 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat VRK3
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VRK3
    Addgene plasmids for VRK3 
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for VRK3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat VRK3
      QuantiTect SYBR Green Assays in human, mouse, rat VRK3
      QuantiFast Probe-based Assays in human, mouse, rat VRK3

    Additional mRNA sequence: 

    AB031052.1 AF514788.1 AK123892.1 AK125747.1 AK225154.1 AK292918.1 AK294802.1 AK303010.1 
    AK303529.1 AK311220.1 BC003546.1 BC023556.2 BC095449.1 

    Selected DOTS entries (see all 25):

    DT.101979050  DT.444386  DT.91756372  DT.100836317  DT.40120674  DT.411371  DT.40123017  DT.95230894 
    DT.424334  DT.100836321  DT.97791785  DT.97848304  DT.75124205  DT.95230903  DT.121502554  DT.92020322 
    DT.100836318  DT.100037067  DT.100836315  DT.121502544  DT.121502573  DT.91756370  DT.121502574  DT.91870679 

    Selected AceView cDNA sequences (see all 377):

    BM922526 BM922031 AK123892 BQ066426 BX479817 BQ642060 BG747071 AI703312 
    AA460400 BQ642137 CR596704 AA604877 BU171193 BQ061948 AW628001 BQ705910 
    T30566 BQ063097 BP372333 BG056226 BM906732 BQ182118 BE673202 AI027264 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for VRK3 (see all 15)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^
    SP1:                          -     -     -                       -                                                                                         -   
    SP2:                                      -                       -                                                                                         -   
    SP3:                                      -                       -                                                                                         -   
    SP4:                                      -                       -     -                                                                                       
    SP5:                                                              -     -                                                                                       

    ExUns: 18 ^ 19a · 19b ^ 20a · 20b ^ 21a · 21b
    SP1:  -     -                                 
    SP2:  -     -                                 
    SP3:                                          
    SP4:                                          
    SP5:                                          


    ECgene alternative splicing isoforms for VRK3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    VRK3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGAGGAACA
    VRK3 Expression
    About this image

    VRK3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    VRK3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.443330
        Custom PCR Arrays for VRK3
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VRK3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for VRK3 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Vrk31 , 5 vaccinia related kinase 31, 5 81.53(n)1
    75.28(a)1
      7 (28.90 cM)5
    1015681  NM_133945.11  NP_598706.11 
     447484135 
    chicken
    (Gallus gallus)
    Aves VRK36
    vaccinia related kinase 3
    45(a)
    1 ↔ 1
    14(14279294-14287355)
    lizard
    (Anolis carolinensis)
    Reptilia VRK36
    vaccinia related kinase 3
    60(a)
    1 ↔ 1
    GL343232.1(1548-11352)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.255002 Xenopus laevis transcribed sequence with weak similarity more 75.56(n)    BJ043254.1 
    zebrafish
    (Danio rerio)
    Actinopterygii vrk31 vaccinia related kinase 3 50.83(n)
    46.06(a)
      541443  NM_001013568.2  NP_001013586.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta ball6
    CG88786
    --
    16(a)
    11(a)
    many ↔ many
    many ↔ many
    3R(22690327-22692529)
    2R(8033529-8038562)
    worm
    (Caenorhabditis elegans)
    Secernentea vrk-16
    Protein VRK-1 (vrk-1) mRNA, complete cds
    12(a)
    1 → many
    II(5921967-5924839) WBGene00017895


    ENSEMBL Gene Tree for VRK3 (if available)
    TreeFam Gene Tree for VRK3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for VRK3 gene
    VRK12  CSNK1G32  VRK22  CSNK1D2  ENSG000002593162  CSNK1A12  CSNK1G22  CSNK1A1L2  
    TTBK12  CSNK1E2  CSNK1G12  TTBK22  
    2 SIMAP similar genes for VRK3 using alignment to 13 protein entries:     VRK3_HUMAN (see all proteins):
    VRK1    VRK2

    Find genes that share paralogs with VRK3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for VRK3 (see all 1372)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs38267671,2
    C,F--50479639(+) CAGTTT/CTGGCC 2 -- ds50017Minor allele frequency- C:0.24NA WA EA 366
    rs38267681,2
    C,F--50479658(+) TGCTGG/AGTTAC 2 -- ds500111Minor allele frequency- A:0.25NA WA CSA EA 374
    rs739339201,2
    C,F--50479676(+) AGCCAC/TAGCAC 2 -- ds50012Minor allele frequency- T:0.22WA 120
    rs1159337451,2
    C,F--50479693(+) CCCAAA/GAGAAC 2 -- ds50011Minor allele frequency- G:0.09WA 118
    rs38267691,2
    C,F--50479703(+) CTTTTA/GCAGAT 2 -- ds500111Minor allele frequency- G:0.26NA WA CSA EA 510
    rs10524981,2
    C,F,A--50479759(+) AGAGGT/AGTCAA 2 -- ut31 ese313Minor allele frequency- A:0.24NA WA EA 692
    rs1484588671,2
    C--50479782(+) TCCCCA/C/GCTGTG 4 -- ut310--------
    rs133456721,2
    C,F--50479887(+) CCCTCC/TGGGAG 2 -- ut31 ese35Minor allele frequency- T:0.15NA WA 236
    rs767262211,2
    C,F--50479888(+) CCTCCG/AGGAGG 2 -- ut311Minor allele frequency- A:0.06WA 118
    rs1927739541,2
    --50479899(+) CTAATC/GAGGAC 2 -- ut310--------

    HapMap Linkage Disequilibrium report for VRK3 (50479724 - 50529203 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for VRK3:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv29129CNV Loss19812545
    dgv54n68CNV Loss17160897
    nsv458722CNV Gain19166990
    nsv819518CNV Gain19587683
    esv2751796CNV Gain17911159
    nsv9739CNV Gain+Loss18304495

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing VRK3
    DNA2.0 Custom Variant and Variant Library Synthesis for VRK3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    1 disease for VRK3:    
    About MalaCards
    vaccinia

    1 disease from the University of Copenhagen DISEASES database for VRK3:
    Vaccinia

    Find genes that share disorders with VRK3           About GenesLikeMe

    Genetic Association Database (GAD): VRK3
    Human Genome Epidemiology (HuGE) Navigator: VRK3 (1 document)

    Export disorders for VRK3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for VRK3 gene, integrated from 10 sources (see all 22):
    (articles sorted by number of sources associating them with VRK3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of three paralogous members of the Mammalian vaccinia related kinase family. (PubMed id 14645249)1, 2, 9 Nichols R.J. and Traktman P. (J. Biol. Chem. 2004)
    2. Proteomics identification of nuclear Ran GTPase as an inhibitor of human VRK1 and VRK2 (vaccinia-related kinase) activities. (PubMed id 18617507)1, 2 Sanz-Garcia M.... Lazo P.A. (Mol. Cell. Proteomics 2008)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Role of bivalent cations in structural stabilities of new drug targets--vaccinia-related kinases (VRK) from molecular dynamics simulations. (PubMed id 23082977)1 Fu T....Li G. (Curr. Pharm. Des. 2013)
    5. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    6. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    7. A directed protein interaction network for investigating intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (Sci Signal 2011)
    8. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (Sci. Signal. 2011)
    9. Single-nucleotide polymorphisms, acute rejection, and severity of tubulitis in kidney transplantation, accounting for center-to-center variation. (PubMed id 21085059)4 Israni A....Oetting W.S. (Transplantation 2010)
    10. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (Sci. Signal. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 51231 HGNC: 18996 AceView: VRK3 Ensembl:ENSG00000105053 euGenes: HUgn51231
    ECgene: VRK3 H-InvDB: VRK3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for VRK3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for VRK3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for VRK3 gene:
    Search GeneIP for patents involving VRK3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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