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Aliases for VRK3 Gene

Aliases for VRK3 Gene

  • Vaccinia Related Kinase 3 2 3
  • Serine/Threonine-Protein Pseudokinase VRK3 4
  • Vaccinia-Related Kinase 3 4

External Ids for VRK3 Gene

Previous GeneCards Identifiers for VRK3 Gene

  • GC19M055155
  • GC19M055171
  • GC19M050479
  • GC19M046855

Summaries for VRK3 Gene

Entrez Gene Summary for VRK3 Gene

  • This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. In both human and mouse, this gene has substitutions at several residues within the ATP binding motifs that in other kinases have been shown to be required for catalysis. In vitro assays indicate the protein lacks phosphorylation activity. The protein, however, likely retains its substrate binding capability. This gene is widely expressed in human tissues and its protein localizes to the nucleus. Alternative splicing results in multiple transcripts encoding different isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for VRK3 Gene

VRK3 (Vaccinia Related Kinase 3) is a Protein Coding gene. Diseases associated with VRK3 include vaccinia. Among its related pathways are Cell Cycle / Checkpoint Control and MAPK targets/ Nuclear events mediated by MAP kinases. GO annotations related to this gene include protein kinase activity and protein phosphatase binding. An important paralog of this gene is CSNK1G2.

UniProtKB/Swiss-Prot for VRK3 Gene

  • Inactive kinase that suppresses ERK activity by promoting phosphatase activity of DUSP3 which specifically dephosphorylates and inactivates ERK in the nucleus.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VRK3 Gene

Genomics for VRK3 Gene

Regulatory Elements for VRK3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for VRK3 Gene

49,976,467 bp from pter
50,026,017 bp from pter
49,551 bases
Minus strand

Genomic View for VRK3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for VRK3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VRK3 Gene

Proteins for VRK3 Gene

  • Protein details for VRK3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Inactive serine/threonine-protein kinase VRK3
    Protein Accession:
    Secondary Accessions:
    • A6NEG5
    • A8KA53
    • Q502Y2
    • Q9P2V8

    Protein attributes for VRK3 Gene

    474 amino acids
    Molecular mass:
    52881 Da
    Quaternary structure:
    • Interacts with DUSP3 (By similarity). Interacts with RAN.

    Three dimensional structures from OCA and Proteopedia for VRK3 Gene

    Alternative splice isoforms for VRK3 Gene


neXtProt entry for VRK3 Gene

Proteomics data for VRK3 Gene at MOPED

Post-translational modifications for VRK3 Gene

  • Ubiquitination at Lys275
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for VRK3 (VRK3)

No data available for DME Specific Peptides for VRK3 Gene

Domains for VRK3 Gene

Gene Families for VRK3 Gene

Protein Domains for VRK3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q8IV63
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. VRK subfamily.
genes like me logo Genes that share domains with VRK3: view

Function for VRK3 Gene

Molecular function for VRK3 Gene

UniProtKB/Swiss-Prot Function: Inactive kinase that suppresses ERK activity by promoting phosphatase activity of DUSP3 which specifically dephosphorylates and inactivates ERK in the nucleus.

Gene Ontology (GO) - Molecular Function for VRK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity IBA --
GO:0005524 ATP binding IEA --
GO:0016772 transferase activity, transferring phosphorus-containing groups --
GO:0019903 protein phosphatase binding IDA 22572157
genes like me logo Genes that share ontologies with VRK3: view

Phenotypes for VRK3 Gene

GenomeRNAi human phenotypes for VRK3:
genes like me logo Genes that share phenotypes with VRK3: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for VRK3 Gene

Localization for VRK3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for VRK3 Gene

Subcellular locations from

Jensen Localization Image for VRK3 Gene COMPARTMENTS Subcellular localization image for VRK3 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for VRK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with VRK3: view

Pathways for VRK3 Gene

genes like me logo Genes that share pathways with VRK3: view

Pathways by source for VRK3 Gene

2 Cell Signaling Technology pathways for VRK3 Gene
1 GeneGo (Thomson Reuters) pathway for VRK3 Gene

Gene Ontology (GO) - Biological Process for VRK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation --
GO:0006897 endocytosis IBA --
GO:0008360 regulation of cell shape IBA --
GO:0016055 Wnt signaling pathway IBA --
GO:0018105 peptidyl-serine phosphorylation IBA --
genes like me logo Genes that share ontologies with VRK3: view

Compounds for VRK3 Gene

(2) HMDB Compounds for VRK3 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
  • adenosindiphosphorsaeure
genes like me logo Genes that share compounds with VRK3: view

Transcripts for VRK3 Gene

Unigene Clusters for VRK3 Gene

Vaccinia related kinase 3:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for VRK3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for VRK3 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^
SP1: - - - - -
SP2: - - -
SP3: - - -
SP4: - - -
SP5: - -
SP6: - - - -
SP7: - - - - -
SP8: - - - -
SP9: - - - - -
SP10: - -
SP11: -
SP12: - -
SP13: - - - - - - -

ExUns: 18 ^ 19a · 19b ^ 20a · 20b ^ 21a · 21b
SP1: - -
SP2: - -

Relevant External Links for VRK3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for VRK3 Gene

mRNA expression in normal human tissues for VRK3 Gene

mRNA differential expression in normal tissues according to GTEx for VRK3 Gene

This gene is overexpressed in Testis (5.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for VRK3 Gene

SOURCE GeneReport for Unigene cluster for VRK3 Gene Hs.443330

genes like me logo Genes that share expressions with VRK3: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for VRK3 Gene

Orthologs for VRK3 Gene

This gene was present in the common ancestor of animals.

Orthologs for VRK3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia VRK3 35
  • 98.87 (n)
  • 97.89 (a)
VRK3 36
  • 98 (a)
(Bos Taurus)
Mammalia VRK3 35
  • 83.56 (n)
  • 76.67 (a)
VRK3 36
  • 77 (a)
(Canis familiaris)
Mammalia VRK3 35
  • 83.81 (n)
  • 78.87 (a)
VRK3 36
  • 80 (a)
(Mus musculus)
Mammalia Vrk3 35
  • 81.53 (n)
  • 75.28 (a)
Vrk3 16
Vrk3 36
  • 75 (a)
(Monodelphis domestica)
Mammalia VRK3 36
  • 46 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 11 (a)
-- 36
  • 19 (a)
(Rattus norvegicus)
Mammalia Vrk3 35
  • 81.09 (n)
  • 75.5 (a)
(Gallus gallus)
Aves VRK3 36
  • 45 (a)
(Anolis carolinensis)
Reptilia VRK3 36
  • 60 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.25500 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.7094 35
vrk3 35
  • 51.92 (n)
  • 48.58 (a)
(Danio rerio)
Actinopterygii vrk3 35
  • 50.83 (n)
  • 46.06 (a)
vrk3 36
  • 36 (a)
fruit fly
(Drosophila melanogaster)
Insecta ball 36
  • 16 (a)
CG8878 36
  • 11 (a)
(Caenorhabditis elegans)
Secernentea vrk-1 36
  • 12 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6830 36
  • 32 (a)
Species with no ortholog for VRK3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for VRK3 Gene

Gene Tree for VRK3 (if available)
Gene Tree for VRK3 (if available)

Paralogs for VRK3 Gene

genes like me logo Genes that share paralogs with VRK3: view

Variants for VRK3 Gene

Sequence variations from dbSNP and Humsavar for VRK3 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs15913 -- 49,980,965(+) GGCCT(G/T)ATCCA synonymous-codon, reference, nc-transcript-variant
rs15983 -- 49,979,223(+) ACCTT(C/G/T)AGGTA synonymous-codon, reference, nc-transcript-variant
rs157546 -- 50,021,869(+) ctaca(A/G)aacct intron-variant
rs157547 -- 49,991,825(+) gtgcc(C/T)gagac intron-variant
rs181743 -- 50,019,139(+) cggcc(G/T)gggag intron-variant

Structural Variations from Database of Genomic Variants (DGV) for VRK3 Gene

Variant ID Type Subtype PubMed ID
nsv9739 CNV Gain+Loss 18304495
dgv54n68 CNV Loss 17160897
esv2751796 CNV Gain 17911159
esv29129 CNV Loss 19812545
nsv819518 CNV Gain 19587683
nsv458722 CNV Gain 19166990

Relevant External Links for VRK3 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VRK3 Gene

Disorders for VRK3 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for VRK3 Gene including...

Search for VRK3 Gene in MalaCards »

(1) University of Copenhagen DISEASES for VRK3 Gene

Relevant External Links for VRK3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with VRK3: view

No data available for UniProtKB/Swiss-Prot for VRK3 Gene

Publications for VRK3 Gene

  1. Characterization of three paralogous members of the Mammalian vaccinia related kinase family. (PMID: 14645249) Nichols R.J. … Traktman P. (J. Biol. Chem. 2004) 3 4 23
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Proteomics identification of nuclear Ran GTPase as an inhibitor of human VRK1 and VRK2 (vaccinia-related kinase) activities. (PMID: 18617507) Sanz-Garcia M. … Lazo P.A. (Mol. Cell. Proteomics 2008) 3 4
  4. Proteomic characterization of the human sperm nucleus. (PMID: 21630459) de Mateo S. … Oliva R. (Proteomics 2011) 3
  5. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PMID: 21890473) Wagner S.A. … Choudhary C. (Mol. Cell Proteomics 2011) 3

Products for VRK3 Gene

  • Addgene plasmids for VRK3

Sources for VRK3 Gene

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