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Aliases for VRK3 Gene

Aliases for VRK3 Gene

  • Vaccinia Related Kinase 3 2 3 5
  • Serine/Threonine-Protein Pseudokinase VRK3 4
  • Vaccinia-Related Kinase 3 4

External Ids for VRK3 Gene

Previous GeneCards Identifiers for VRK3 Gene

  • GC19M055155
  • GC19M055171
  • GC19M050479
  • GC19M046855

Summaries for VRK3 Gene

Entrez Gene Summary for VRK3 Gene

  • This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. In both human and mouse, this gene has substitutions at several residues within the ATP binding motifs that in other kinases have been shown to be required for catalysis. In vitro assays indicate the protein lacks phosphorylation activity. The protein, however, likely retains its substrate binding capability. This gene is widely expressed in human tissues and its protein localizes to the nucleus. Alternative splicing results in multiple transcripts encoding different isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for VRK3 Gene

VRK3 (Vaccinia Related Kinase 3) is a Protein Coding gene. Diseases associated with VRK3 include vaccinia. Among its related pathways are Signal transduction_Erk Interactions- Inhibition of Erk. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein serine/threonine kinase activity. An important paralog of this gene is CSNK1G2.

UniProtKB/Swiss-Prot for VRK3 Gene

  • Inactive kinase that suppresses ERK activity by promoting phosphatase activity of DUSP3 which specifically dephosphorylates and inactivates ERK in the nucleus.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VRK3 Gene

Genomics for VRK3 Gene

Regulatory Elements for VRK3 Gene

Promoters for VRK3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around VRK3 on UCSC Golden Path with GeneCards custom track

Genomic Location for VRK3 Gene

Chromosome:
19
Start:
49,976,467 bp from pter
End:
50,026,017 bp from pter
Size:
49,551 bases
Orientation:
Minus strand

Genomic View for VRK3 Gene

Genes around VRK3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
VRK3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for VRK3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VRK3 Gene

Proteins for VRK3 Gene

  • Protein details for VRK3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IV63-VRK3_HUMAN
    Recommended name:
    Inactive serine/threonine-protein kinase VRK3
    Protein Accession:
    Q8IV63
    Secondary Accessions:
    • A6NEG5
    • A8KA53
    • Q502Y2
    • Q9P2V8

    Protein attributes for VRK3 Gene

    Size:
    474 amino acids
    Molecular mass:
    52881 Da
    Quaternary structure:
    • Interacts with DUSP3 (By similarity). Interacts with RAN.

    Three dimensional structures from OCA and Proteopedia for VRK3 Gene

    Alternative splice isoforms for VRK3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for VRK3 Gene

Proteomics data for VRK3 Gene at MOPED

Post-translational modifications for VRK3 Gene

  • Ubiquitination at Lys 275
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for VRK3 (VRK3)

No data available for DME Specific Peptides for VRK3 Gene

Domains & Families for VRK3 Gene

Gene Families for VRK3 Gene

Protein Domains for VRK3 Gene

Graphical View of Domain Structure for InterPro Entry

Q8IV63

UniProtKB/Swiss-Prot:

VRK3_HUMAN :
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. VRK subfamily.
Domain:
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. VRK subfamily.
genes like me logo Genes that share domains with VRK3: view

Function for VRK3 Gene

Molecular function for VRK3 Gene

UniProtKB/Swiss-Prot Function:
Inactive kinase that suppresses ERK activity by promoting phosphatase activity of DUSP3 which specifically dephosphorylates and inactivates ERK in the nucleus.
genes like me logo Genes that share phenotypes with VRK3: view

Animal Model Products

  • Taconic Biosciences Mouse Models for VRK3

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for VRK3 Gene

Localization for VRK3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for VRK3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for VRK3 Gene COMPARTMENTS Subcellular localization image for VRK3 gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for VRK3 Gene

Pathways & Interactions for VRK3 Gene

genes like me logo Genes that share pathways with VRK3: view

Pathways by source for VRK3 Gene

1 GeneGo (Thomson Reuters) pathway for VRK3 Gene

Gene Ontology (GO) - Biological Process for VRK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008360 regulation of cell shape IBA --
genes like me logo Genes that share ontologies with VRK3: view

No data available for SIGNOR curated interactions for VRK3 Gene

Drugs & Compounds for VRK3 Gene

(1) Drugs for VRK3 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0

(1) Additional Compounds for VRK3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with VRK3: view

Transcripts for VRK3 Gene

Unigene Clusters for VRK3 Gene

Vaccinia related kinase 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for VRK3 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^
SP1: - - - - -
SP2: - - -
SP3: - - -
SP4: - - -
SP5: - -
SP6: - - - -
SP7: - - - - -
SP8: - - - -
SP9: - - - - -
SP10: - -
SP11: -
SP12: - -
SP13: - - - - - - -
SP14:
SP15:

ExUns: 18 ^ 19a · 19b ^ 20a · 20b ^ 21a · 21b
SP1: - -
SP2: - -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:

Relevant External Links for VRK3 Gene

GeneLoc Exon Structure for
VRK3
ECgene alternative splicing isoforms for
VRK3

Expression for VRK3 Gene

mRNA expression in normal human tissues for VRK3 Gene

mRNA differential expression in normal tissues according to GTEx for VRK3 Gene

This gene is overexpressed in Testis (x5.5).

Protein differential expression in normal tissues from HIPED for VRK3 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (20.1), Testis (17.1), and CD8 Tcells (9.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for VRK3 Gene



SOURCE GeneReport for Unigene cluster for VRK3 Gene Hs.443330

genes like me logo Genes that share expression patterns with VRK3: view

Protein tissue co-expression partners for VRK3 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for VRK3 Gene

Orthologs for VRK3 Gene

This gene was present in the common ancestor of animals.

Orthologs for VRK3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia VRK3 35
  • 83.56 (n)
  • 76.67 (a)
VRK3 36
  • 77 (a)
OneToOne
dog
(Canis familiaris)
Mammalia VRK3 35
  • 83.81 (n)
  • 78.87 (a)
VRK3 36
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Vrk3 35
  • 81.53 (n)
  • 75.28 (a)
Vrk3 16
Vrk3 36
  • 75 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia VRK3 35
  • 98.87 (n)
  • 97.89 (a)
VRK3 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Vrk3 35
  • 81.09 (n)
  • 75.5 (a)
oppossum
(Monodelphis domestica)
Mammalia VRK3 36
  • 46 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 11 (a)
ManyToMany
-- 36
  • 19 (a)
ManyToMany
chicken
(Gallus gallus)
Aves VRK3 36
  • 45 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia VRK3 36
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.7094 35
vrk3 35
  • 51.92 (n)
  • 48.58 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.25500 35
zebrafish
(Danio rerio)
Actinopterygii vrk3 35
  • 50.83 (n)
  • 46.06 (a)
vrk3 36
  • 36 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta ball 36
  • 16 (a)
ManyToMany
CG8878 36
  • 11 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea vrk-1 36
  • 12 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6830 36
  • 32 (a)
OneToMany
Species with no ortholog for VRK3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for VRK3 Gene

ENSEMBL:
Gene Tree for VRK3 (if available)
TreeFam:
Gene Tree for VRK3 (if available)

Paralogs for VRK3 Gene

genes like me logo Genes that share paralogs with VRK3: view

Variants for VRK3 Gene

Sequence variations from dbSNP and Humsavar for VRK3 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs2033262 - 50,009,349(+) TAGGA(A/G)AGGTT intron-variant, nc-transcript-variant, reference, missense
rs11547882 - 50,007,803(+) TTTGG(G/T)GGTTG nc-transcript-variant, reference, missense
rs11547883 - 50,007,605(+) CTGGA(A/G)GGACT nc-transcript-variant, reference, missense
rs10410075 - 49,994,881(+) GGGCC(A/G)ACTGA nc-transcript-variant, reference, missense
rs10409482 - 49,994,821(+) GCCGG(C/T)AGGCC nc-transcript-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for VRK3 Gene

Variant ID Type Subtype PubMed ID
nsv9739 CNV Gain+Loss 18304495
dgv54n68 CNV Loss 17160897
esv2751796 CNV Gain 17911159
esv29129 CNV Loss 19812545
nsv819518 CNV Gain 19587683
nsv458722 CNV Gain 19166990

Variation tolerance for VRK3 Gene

Residual Variation Intolerance Score: 79.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.13; 87.78% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for VRK3 Gene

HapMap Linkage Disequilibrium report
VRK3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VRK3 Gene

Disorders for VRK3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for VRK3 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
vaccinia
- elite association - COSMIC cancer census association via MalaCards
Search VRK3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for VRK3

Genetic Association Database (GAD)
VRK3
Human Genome Epidemiology (HuGE) Navigator
VRK3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
VRK3
genes like me logo Genes that share disorders with VRK3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for VRK3 Gene

Publications for VRK3 Gene

  1. Characterization of three paralogous members of the Mammalian vaccinia related kinase family. (PMID: 14645249) Nichols R.J. … Traktman P. (J. Biol. Chem. 2004) 3 4 23 67
  2. Presumed pseudokinase VRK3 functions as a BAF kinase. (PMID: 25899223) Park C.H. … Kim K.T. (Biochim. Biophys. Acta 2015) 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Role of bivalent cations in structural stabilities of new drug targets--vaccinia-related kinases (VRK) from molecular dynamics simulations. (PMID: 23082977) Fu T. … Li G. (Curr. Pharm. Des. 2013) 3
  5. Sensitive detection of idiotypic platelet-reactive alloantibodies by an electrical protein chip. (PMID: 22572157) Quiel A. … Schweder T. (Biosens Bioelectron 2012) 3

Products for VRK3 Gene

Sources for VRK3 Gene

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