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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

VRK3 Gene

protein-coding   GIFtS: 59
GCID: GC19M050479

Vaccinia Related Kinase 3

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Vaccinia Related Kinase 31 2
Serine/Threonine-Protein Pseudokinase VRK32 3
Vaccinia-Related Kinase 32 3
Inactive Serine/Threonine-Protein Kinase VRK32
Serine/Threonine-Protein Kinase VRK32

External Ids:    HGNC: 189961   Entrez Gene: 512312   Ensembl: ENSG000001050537   UniProtKB: Q8IV633   

Export aliases for VRK3 gene to outside databases

Previous GC identifers: GC19M055155 GC19M055171 GC19M046855


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for VRK3 Gene:
This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. In
both human and mouse, this gene has substitutions at several residues within the ATP binding motifs that in other
kinases have been shown to be required for catalysis. In vitro assays indicate the protein lacks phosphorylation
activity. The protein, however, likely retains its substrate binding capability. This gene is widely expressed in
human tissues and its protein localizes to the nucleus. Alternative splicing results in multiple transcripts
encoding different isoforms. (provided by RefSeq, Jul 2008)

GeneCards Summary for VRK3 Gene: 
VRK3 (vaccinia related kinase 3) is a protein-coding gene. Diseases associated with VRK3 include vaccinia, and among its related super-pathways are Signal transduction Erk Interactions- Inhibition of Erk and DNA Damage. GO annotations related to this gene include protein kinase activity and ATP binding. An important paralog of this gene is VRK1.

UniProtKB/Swiss-Prot: VRK3_HUMAN, Q8IV63
Function: Inactive kinase that suppresses ERK activity by promoting phosphatase activity of DUSP3 which
specifically dephosphorylates and inactivates ERK in the nucleus (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NT_011109.16  NC_018930.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the VRK3 gene promoter:
         STAT5B   NCX/Ncx   Bach2   STAT5A   AREB6   E2F-1   E2F   Msx-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidVRK3 promoter sequence
   Search SABiosciences Chromatin IP Primers for VRK3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat VRK3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13   Ensembl cytogenetic band:  19q13.33   HGNC cytogenetic band: 19q13.33

VRK3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
VRK3 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M050479:  view genomic region     (about GC identifiers)

Start:
50,479,724 bp from pter      End:
50,529,203 bp from pter
Size:
49,480 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: VRK3_HUMAN, Q8IV63 (See protein sequence)
Recommended Name: Inactive serine/threonine-protein kinase VRK3  
Size: 474 amino acids; 52881 Da
Subunit: Interacts with DUSP3 (By similarity). Interacts with RAN
Subcellular location: Nucleus
Caution: Inactive as a kinase due to its inability to bind ATP (PubMed:19141289)
1 PDB 3D structure from and Proteopedia for VRK3:
2JII (3D)    
Secondary accessions: A6NEG5 A8KA53 Q502Y2 Q9P2V8
Alternative splicing: 3 isoforms:  Q8IV63-1   Q8IV63-2   Q8IV63-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for VRK3: NX_Q8IV63

Explore proteomics data for VRK3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8IV63

  • VRK3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    VRK3 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001020949.1  NP_057524.3  

    ENSEMBL proteins: 
     ENSP00000324636   ENSP00000366210   ENSP00000469880   ENSP00000472217   ENSP00000470156  
     ENSP00000473171   ENSP00000471061   ENSP00000472541   ENSP00000473222   ENSP00000469710  
     ENSP00000469325   ENSP00000469802   ENSP00000471661   ENSP00000468979   ENSP00000470940  
     ENSP00000469400   ENSP00000469092   ENSP00000470359   ENSP00000414907  

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    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for VRK3
    Cloud-Clone Corp. Proteins for VRK3 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    VRK3 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IUPHAR Guide to PHARMACOLOGY protein family classification: vaccinia related kinase 3 
    Vaccina related kinase (VRK) family

    2 InterPro protein domains:
     IPR011009 Kinase-like_dom
     IPR000719 Prot_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry Q8IV63

    ProtoNet protein and cluster: Q8IV63

    UniProtKB/Swiss-Prot: VRK3_HUMAN, Q8IV63
    Similarity: Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. VRK subfamily
    Similarity: Contains 1 protein kinase domain


    VRK3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: VRK3_HUMAN, Q8IV63
    Function: Inactive kinase that suppresses ERK activity by promoting phosphatase activity of DUSP3 which
    specifically dephosphorylates and inactivates ERK in the nucleus (By similarity)

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity IEA--
    GO:0005524ATP binding IEA--
    GO:0016772transferase activity, transferring phosphorus-containing groups ----
    GO:0019903protein phosphatase binding IEA--
         
    VRK3 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for VRK3:
     Decreased mitotic index 

         1 MGI phenotypic allele for Vrk3 (no phenotypes)

    VRK3 for phenotypes           About GeneDecksing

    Animal Models:
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    6 QIAGEN miScript miRNA Assays for microRNAs that regulate VRK3:
    hsa-miR-214 hsa-miR-23b hsa-miR-130a* hsa-miR-23a hsa-miR-23c hsa-miR-761
    SwitchGear 3'UTR luciferase reporter plasmidVRK3 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for VRK3 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Signal transduction Erk Interactions: Inhibition of Erk
    Signal transduction Erk Interactions: Inhibition of Erk0.92
    2DNA Damage
    Cell Cycle / Checkpoint Control0.32
    3MAP Kinase Signaling
    MAP Kinase Signaling

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for VRK3
        Signal transduction Erk Interactions- Inhibition of Erk


    2 Cell Signaling Technology (CST) Pathways for VRK3
        MAP Kinase Signaling
    Cell Cycle / Checkpoint Control

    1 GeneGo (Thomson Reuters) Pathway for VRK3
        Signal transduction Erk Interactions- Inhibition of Erk



    VRK3 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for VRK3

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5/14 Interacting proteins for VRK3 (Q8IV632, 3 ENSP000003246364) via UniProtKB, MINT, STRING, and/or I2D (see all 14)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CSNK2BP678702, 3MINT-8253781 I2D: score=2 
    ENSG00000206406P678702, 3MINT-8253781 I2D: score=2 
    ENSG00000224398P678702, 3MINT-8253781 I2D: score=2 
    ENSG00000224774P678702, 3MINT-8253781 I2D: score=2 
    ENSG00000228875P678702, 3MINT-8253781 I2D: score=2 
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation ----
    GO:0032516positive regulation of phosphoprotein phosphatase activity IEA--
    GO:0070373negative regulation of ERK1 and ERK2 cascade IEA--

    VRK3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for VRK3

    2 HMDB Compounds for VRK3    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    Search CenterWatch for drugs/clinical trials and news about VRK3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for VRK3 gene (2 alternative transcripts): 
    NM_001025778.1  NM_016440.3  

    Unigene Cluster for VRK3:

    Vaccinia related kinase 3
    Hs.443330  [show with all ESTs]
    Unigene Representative Sequence: AK123892
    18/27 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 27):
    ENST00000316763(uc002prg.2 uc002prh.1 uc002prk.2 uc010ent.2 uc002prl.3 uc010ybn.1)
    ENST00000377011(uc002pri.1) ENST00000599538 ENST00000596814 ENST00000601341
    ENST00000594948 ENST00000598553 ENST00000601912 ENST00000594092 ENST00000593912
    ENST00000600284 ENST00000593919 ENST00000594090 ENST00000596121 ENST00000424804
    ENST00000599342 ENST00000600137 ENST00000594104
    miRNA
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    6 QIAGEN miScript miRNA Assays for microRNAs that regulate VRK3:
    hsa-miR-214 hsa-miR-23b hsa-miR-130a* hsa-miR-23a hsa-miR-23c hsa-miR-761
    SwitchGear 3'UTR luciferase reporter plasmidVRK3 3' UTR sequence
    Inhib. RNA
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VRK3
    Sirion Biotech Customized lentivirus for stable overexpression of VRK3 
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat VRK3

    Additional mRNA sequence: 

    AB031052.1 AF514788.1 AK123892.1 AK125747.1 AK225154.1 AK292918.1 AK294802.1 AK303010.1 
    AK303529.1 AK311220.1 BC003546.1 BC023556.2 BC095449.1 

    24/25 DOTS entries (see all 25):

    DT.101979050  DT.444386  DT.100836317  DT.91756372  DT.40120674  DT.411371  DT.40123017  DT.95230894 
    DT.424334  DT.100836321  DT.97791785  DT.97848304  DT.75124205  DT.95230903  DT.121502554  DT.92020322 
    DT.100836318  DT.100037067  DT.100836315  DT.121502544  DT.121502573  DT.91756370  DT.121502574  DT.91870679 

    24/377 AceView cDNA sequences (see all 377):

    BQ691691 CA307083 AA460400 AW628001 BQ061948 AI823329 BQ063097 BM931401 
    BM800474 CR618423 BG751504 BX479817 CD359612 AI703312 AL527317 BM553949 
    CR604545 CK820149 CR594746 AK123892 BI911231 BX402717 CR606658 AI027264 

    GeneLoc Exon Structure

    5/15 Alternative Splicing Database (ASD) splice patterns (SP) for VRK3 (see all 15)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^
    SP1:                          -     -     -                       -                                                                                         -   
    SP2:                                      -                       -                                                                                         -   
    SP3:                                      -                       -                                                                                         -   
    SP4:                                      -                       -     -                                                                                       
    SP5:                                                              -     -                                                                                       

    ExUns: 18 ^ 19a · 19b ^ 20a · 20b ^ 21a · 21b
    SP1:  -     -                                 
    SP2:  -     -                                 
    SP3:                                          
    SP4:                                          
    SP5:                                          


    ECgene alternative splicing isoforms for VRK3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    VRK3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGAGGAACA
    VRK3 Expression
    About this image


    See VRK3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for VRK3

    SOURCE GeneReport for Unigene cluster: Hs.443330
        SABiosciences Custom PCR Arrays for VRK3
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VRK3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for VRK3 gene from 8/17 species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Vrk31 , 5 vaccinia related kinase 31, 5 81.53(n)1
    75.28(a)1
      7 (28.90 cM)5
    1015681  NM_133945.11  NP_598706.11 
     447484135 
    chicken
    (Gallus gallus)
    Aves VRK31 vaccinia related kinase 3 62.96(n)
    59.03(a)
      770440  XM_001233774.2  XP_001233775.2 
    lizard
    (Anolis carolinensis)
    Reptilia VRK36
    Uncharacterized protein
    60(a)
    1 ↔ 1
    GL343232.1(1548-11352)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.255002 Xenopus laevis transcribed sequence with weak similarity more 75.56(n)    BJ043254.1 
    zebrafish
    (Danio rerio)
    Actinopterygii vrk31 vaccinia related kinase 3 50.39(n)
    45.06(a)
      541443  NM_001013568.1  NP_001013586.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG88786
    ball6
    ballchen
    9(a)
    14(a)
    many ↔ many
    many ↔ many
    2R(8033529-8038562)
    3R(22690327-22692529)
    worm
    (Caenorhabditis elegans)
    Secernentea vrk-16
    Serine/threonine-protein kinase VRK1
    12(a)
    1 → many
    II(5921965-5924839)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes YCK26
    YCK16
    (see all 3)
    Palmitoylated plasma membrane-bound casein kinase ...
    Palmitoylated plasma membrane-bound casein kinase ...
    (see all 3)
    12(a)
    11(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    XIV(343636-345276)
    VIII(372694-374310)


    ENSEMBL Gene Tree for VRK3 (if available)
    TreeFam Gene Tree for VRK3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for VRK3 gene
    VRK12  CSNK1G32  VRK22  CSNK1D2  ENSG000002593162  CSNK1A12  CSNK1G22  CSNK1A1L2  
    TTBK12  CSNK1E2  CSNK1G12  TTBK22  
    2 SIMAP similar genes for VRK3 using alignment to 13 protein entries:     VRK3_HUMAN (see all proteins):
    VRK1    VRK2

    VRK3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1372 SNPs in VRK3 are shown (see all 1372)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs38267671,2
    C,F--50479639(+) CAGTTT/CTGGCC 2 -- ds50017Minor allele frequency- C:0.24NA WA EA 366
    rs38267681,2
    C,F--50479658(+) TGCTGG/AGTTAC 2 -- ds500111Minor allele frequency- A:0.25NA WA CSA EA 374
    rs739339201,2
    C,F--50479676(+) AGCCAC/TAGCAC 2 -- ds50012Minor allele frequency- T:0.22WA 120
    rs1159337451,2
    C,F--50479693(+) CCCAAA/GAGAAC 2 -- ds50011Minor allele frequency- G:0.09WA 118
    rs38267691,2
    C,F--50479703(+) CTTTTA/GCAGAT 2 -- ds500111Minor allele frequency- G:0.26NA WA CSA EA 510
    rs10524981,2
    C,F,A--50479759(+) AGAGGT/AGTCAA 2 -- ut31 ese313Minor allele frequency- A:0.24NA WA EA 692
    rs1484588671,2
    C--50479782(+) TCCCCA/C/GCTGTG 4 -- ut310--------
    rs133456721,2
    C,F--50479887(+) CCCTCC/TGGGAG 2 -- ut31 ese35Minor allele frequency- T:0.15NA WA 236
    rs767262211,2
    C,F--50479888(+) CCTCCG/AGGAGG 2 -- ut311Minor allele frequency- A:0.06WA 118
    rs1927739541,2
    --50479899(+) CTAATC/GAGGAC 2 -- ut310--------

    HapMap Linkage Disequilibrium report for VRK3 (50479724 - 50529203 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for VRK3:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv29129CNV Loss19812545
    dgv54n68CNV Loss17160897
    nsv458722CNV Gain19166990
    nsv819518CNV Gain19587683
    esv2751796CNV Gain17911159
    nsv9739CNV Gain+Loss18304495

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for VRK3:    About MalaCards
    vaccinia    

    1 disease from the University of Copenhagen DISEASES database for VRK3:
    Vaccinia

    VRK3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): VRK3
    Human Genome Epidemiology (HuGE) Navigator: VRK3 (1 document)

    Export disorders for VRK3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for VRK3 gene, integrated from 9 sources (see all 21):
    (articles sorted by number of sources associating them with VRK3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of three paralogous members of the Mammalian vaccinia related kinase family. (PubMed id 14645249)1, 2, 9 Nichols R.J. and Traktman P. (2004)
    2. Proteomics identification of nuclear Ran GTPase as an inhibitor of human VRK1 and VRK2 (vaccinia-related kinase) activities. (PubMed id 18617507)1, 2 Sanz-Garcia M....Lazo P.A. (2008)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Role of bivalent cations in structural stabilities of new drug targets--vaccinia-related kinases (VRK) from molecular dynamics simulat ions. (PubMed id 23082977)1 Fu T....Li G. (2013)
    5. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    6. A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
    7. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
    8. Single-nucleotide polymorphisms, acute rejection, and severity of tubulitis in kidney transplantation, accounting for center-to-center variation. (PubMed id 21085059)4 Israni A....Oetting W.S. (2010)
    9. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
    10. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 51231 HGNC: 18996 AceView: VRK3 Ensembl:ENSG00000105053 euGenes: HUgn51231
    ECgene: VRK3 H-InvDB: VRK3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for VRK3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for VRK3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for VRK3 gene:
    Search GeneIP for patents involving VRK3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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