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VRK2 Gene

protein-coding   GIFtS: 59
GCID: GC02P058185

Vaccinia Related Kinase 2

  See VRK2-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Vaccinia Related Kinase 21 2
EC 2.7.11.13 8
Serine/Threonine-Protein Kinase VRK22
Vaccinia Virus B1R-Related Kinase 22
Vaccinia-Related Kinase 23

External Ids:    HGNC: 127191   Entrez Gene: 74442   Ensembl: ENSG000000281167   OMIM: 6021695   UniProtKB: Q86Y073   

Export aliases for VRK2 gene to outside databases

Previous GC identifers: GC02P058402 GC02P058092 GC02P058248


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for VRK2 Gene:
This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. The
encoded protein acts as an effector of signaling pathways that regulate apoptosis and tumor cell growth. Variants
in this gene have been associated with schizophrenia. Alternative splicing results in multiple transcript
variants that differ in their subcellular localization and biological activity. (provided by RefSeq, Jan 2014)

GeneCards Summary for VRK2 Gene:
VRK2 (vaccinia related kinase 2) is a protein-coding gene. Diseases associated with VRK2 include benign familial infantile epilepsy, and vaccinia. GO annotations related to this gene include protein serine/threonine kinase activity. An important paralog of this gene is VRK3.

UniProtKB/Swiss-Prot: VRK2_HUMAN, Q86Y07
Function: Serine/threonine kinase that regulates several signal transduction pathways. Isoform 1 modulates the
stress response to hypoxia and cytokines, such as interleukin-1 beta (IL1B) and this is dependent on its
interaction with MAPK8IP1, which assembles mitogen-activated protein kinase (MAPK) complexes. Inhibition of
signal transmission mediated by the assembly of MAPK8IP1-MAPK complexes reduces JNK phosphorylation and
JUN-dependent transcription. Phosphorylates 'Thr-18' of p53/TP53, histone H3, and may also phosphorylate
MAPK8IP1. Phosphorylates BANF1 and disrupts its ability to bind DNA and reduces its binding to LEM
domain-containing proteins. Downregulates the transactivation of transcription induced by ERBB2, HRAS, BRAF, and
MEK1. Blocks the phosphorylation of ERK in response to ERBB2 and HRAS. Can also phosphorylate the following
substrates that are commonly used to establish in vitro kinase activity: casein, MBP and histone H2B, but it is
not sure that this is physiologically relevant
Function: Isoform 2 phosphorylates 'Thr-18' of p53/TP53, as well as histone H3. Reduces p53/TP53 ubiquitination by
MDM2, promotes p53/TP53 acetylation by EP300 and thereby increases p53/TP53 stability and activity

Gene Wiki entry for VRK2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the VRK2 gene promoter:
         Nkx3-1   p53   HNF-4alpha2   E4BP4   HNF-4alpha1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidVRK2 promoter sequence
   Search Chromatin IP Primers for VRK2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat VRK2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p16.1   Ensembl cytogenetic band:  2p16.1   HGNC cytogenetic band: 2p16.1

VRK2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
VRK2 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P058185:  view genomic region     (about GC identifiers)

Start:
58,134,786 bp from pter      End:
58,387,055 bp from pter
Size:
252,270 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: VRK2_HUMAN, Q86Y07 (See protein sequence)
Recommended Name: Serine/threonine-protein kinase VRK2  
Size: 508 amino acids; 58141 Da
Subunit: Isoform 1 interacts with MAP3K7, MAP2K7, MAP2K1 and KSR1. Isoform 1 and isoform 2 interact with RAN and
MAPK8IP1. Isoform 1 interacts with Epstein-Barr virus BHRF1; this interaction is involved in protecting cells
from apoptosis
Sequence caution: Sequence=CAD54446.2; Type=Miscellaneous discrepancy; Note=Aberrant splicing;
1 PDB 3D structure from and Proteopedia for VRK2:
2V62 (3D)    
Secondary accessions: B4DKL0 D6W5D4 D6W5D6 Q49AK9 Q53EU9 Q53S39 Q53S77 Q53TU1 Q86Y08 Q86Y09
Q86Y10 Q86Y11 Q86Y12 Q8IXI5 Q99987
Alternative splicing: 5 isoforms:  Q86Y07-1   Q86Y07-2   Q86Y07-3   Q86Y07-4   Q86Y07-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for VRK2: NX_Q86Y07

Explore proteomics data for VRK2 at MOPED

Post-translational modifications: 

  • Isoform 1 and isoform 2 are autophosphorylated1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • 2 DME Specific Peptides for VRK2 (Q86Y07)
     HENEYVHG  EYVHGDIKA 


    See VRK2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (9 alternative transcripts): 
    NP_001123952.1  NP_001123953.1  NP_001123954.1  NP_001123955.1  NP_001275765.1  NP_001275766.1  NP_001275767.1  NP_001275768.1  
    NP_006287.2  

    ENSEMBL proteins: 
     ENSP00000408002   ENSP00000402375   ENSP00000342381   ENSP00000400006   ENSP00000398323  
     ENSP00000404961   ENSP00000404156  

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    Cloud-Clone Corp. Proteins for VRK2

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: vaccinia related kinase 2
    Vaccina related kinase (VRK) family

    3 InterPro protein domains:
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_dom

    Graphical View of Domain Structure for InterPro Entry Q86Y07

    ProtoNet protein and cluster: Q86Y07

    UniProtKB/Swiss-Prot: VRK2_HUMAN, Q86Y07
    Similarity: Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. VRK subfamily
    Similarity: Contains 1 protein kinase domain


    Find genes that share domains with VRK2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: VRK2_HUMAN, Q86Y07
    Function: Serine/threonine kinase that regulates several signal transduction pathways. Isoform 1 modulates the
    stress response to hypoxia and cytokines, such as interleukin-1 beta (IL1B) and this is dependent on its
    interaction with MAPK8IP1, which assembles mitogen-activated protein kinase (MAPK) complexes. Inhibition of
    signal transmission mediated by the assembly of MAPK8IP1-MAPK complexes reduces JNK phosphorylation and
    JUN-dependent transcription. Phosphorylates 'Thr-18' of p53/TP53, histone H3, and may also phosphorylate
    MAPK8IP1. Phosphorylates BANF1 and disrupts its ability to bind DNA and reduces its binding to LEM
    domain-containing proteins. Downregulates the transactivation of transcription induced by ERBB2, HRAS, BRAF, and
    MEK1. Blocks the phosphorylation of ERK in response to ERBB2 and HRAS. Can also phosphorylate the following
    substrates that are commonly used to establish in vitro kinase activity: casein, MBP and histone H2B, but it is
    not sure that this is physiologically relevant
    Function: Isoform 2 phosphorylates 'Thr-18' of p53/TP53, as well as histone H3. Reduces p53/TP53 ubiquitination by
    MDM2, promotes p53/TP53 acetylation by EP300 and thereby increases p53/TP53 stability and activity
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: RAN inhibits its autophosphorylation and its ability to phosphorylate histone H3

         Genatlas biochemistry entry for VRK2:
    vaccinia-related kinase 2,widely expressed

         Enzyme Number (IUBMB): EC 2.7.11.11 2

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity IDA14645249
    GO:0005515protein binding IPI16963744
    GO:0005524ATP binding IEA--
    GO:0016772transferase activity, transferring phosphorus-containing groups ----
         
    Find genes that share ontologies with VRK2           About GenesLikeMe


    Phenotypes:
         4 GenomeRNAi human phenotypes for VRK2:
     Decreased focal adhesion (FA)   Increased S DNA content  Increased cell death HMECs cel  Synthetic lethal with c-Myc af 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for VRK2
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    Addgene plasmids for VRK2 

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    VRK2_HUMAN, Q86Y07: Isoform 1: Cytoplasm. Endoplasmic reticulum membrane; Single-pass type IV membrane protein
    (Potential). Mitochondrion membrane; Single-pass type IV membrane protein (Potential)
    VRK2_HUMAN, Q86Y07: Isoform 2: Cytoplasm. Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    mitochondrion5
    nucleus5
    cytosol3
    extracellular1
    golgi apparatus1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA16704422
    GO:0005737cytoplasm IDA16704422
    GO:0005783endoplasmic reticulum IDA--
    GO:0005789endoplasmic reticulum membrane IDA18286207
    GO:0016020membrane ----

    Find genes that share ontologies with VRK2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for VRK2 About    
    See pathways by source

    SuperPathContained pathways About
    1Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    M Phase0.62
    Cell Cycle0.90
    2Nuclear Envelope Reassembly
    Nuclear Envelope Reassembly
    Initiation of Nuclear Envelope Reformation0.00
    Clearance of Nuclear Envelope Membranes from Chromatin0.00
    3Mitotic Metaphase and Anaphase
    Mitotic Anaphase0.94
    Mitotic Metaphase and Anaphase0.93
    4Regulation of Glucokinase by Glucokinase Regulatory Protein
    Nuclear Envelope Breakdown0.77
    5RNA Polymerase I Promoter Opening
    Mitotic Prophase0.56



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for VRK2
    Interactions:

        GeneGlobe Interaction Network for VRK2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for VRK2 (Q86Y071, 3 ENSP000003423814) via UniProtKB, MINT, STRING, and/or I2D (see all 70)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RANP628261, 3, ENSP000003961274EBI-1207633,EBI-286642 I2D: score=2 STRING: ENSP00000396127
    KSR1Q8IVT51, 3, ENSP000002687634EBI-1207615,EBI-486984 I2D: score=1 STRING: ENSP00000268763
    MAP2K1Q027501, 3, ENSP000003024864EBI-1207615,EBI-492564 I2D: score=1 STRING: ENSP00000302486
    BCL2P104153, ENSP000003296234I2D: score=2 STRING: ENSP00000329623
    MAP3K7O433183, ENSP000003583354I2D: score=2 STRING: ENSP00000358335
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation TAS9344656
    GO:0016032viral process IEA--
    GO:0019048modulation by virus of host morphology or physiology ----
    GO:0034599cellular response to oxidative stress IMP17709393
    GO:0043408regulation of MAPK cascade IMP--

    Find genes that share ontologies with VRK2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for VRK2

    2 HMDB Compounds for VRK2    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for VRK2 gene (9 alternative transcripts): 
    NM_001130480.2  NM_001130481.2  NM_001130482.2  NM_001130483.2  NM_001288836.1  NM_001288837.1  NM_001288838.1  NM_001288839.1  
    NM_006296.6  

    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000435505(uc002rzo.2) ENST00000417641(uc010fcb.2) ENST00000478687
    ENST00000463222 ENST00000340157 ENST00000432057 ENST00000440705(uc010yph.1)
    ENST00000428021 ENST00000412104(uc002rzt.3 uc002rzs.3 uc002rzv.3 uc010fcd.3 uc002rzu.3 uc010fcc.3 uc002rzp.3 uc010ypg.2)

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    Selected AceView cDNA sequences (see all 158):

    BI792449 AY228372 AA282292 AA641955 AY228370 BX094979 AL036075 AL549153 
    AI249475 AL046040 CA432823 BC027854 CD365181 NM_006296 CR605412 CR624256 
    AY228367 H67557 AI383951 BM997500 BM667337 BG576907 CR622767 CA418927 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    VRK2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAAAGTGCAG
    VRK2 Expression
    About this image


    VRK2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Limb (Muscoskeletal System)
             Prechondrocytic Mesenchymal Cells Zeugopod
     
     Bone (Muscoskeletal System)
             Prechondrocytic Mesenchymal Cells Zeugopod
     
     Cartilage (Muscoskeletal System)
             Prechondrocytic Mesenchymal Cells Zeugopod
     
     Brain (Nervous System)
             Cerebral Cortex
    VRK2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    VRK2 Protein Expression

    UniProtKB/Swiss-Prot: VRK2_HUMAN, Q86Y07
    Tissue specificity: Isoform 1 and isoform 2 are expressed in various tumor cell lines. Expression of isoform 1
    inversely correlates with ERBB2 in breast carcinomas (at protein level). Widely expressed. Highly expressed in
    fetal liver, skeletal muscle, pancreas, heart, peripheral blood leukocytes and testis

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for VRK2 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Vrk21 , 5 vaccinia related kinase 21, 5 78.6(n)1
    70.18(a)1
      11 (15.94 cM)5
    699221  NM_027260.31  NP_081536.21 
     264713225 
    chicken
    (Gallus gallus)
    Aves VRK21 vaccinia related kinase 2 65.14(n)
    57.17(a)
      100857144  XM_004940112.1  XP_004940169.1 
    lizard
    (Anolis carolinensis)
    Reptilia VRK26
    vaccinia related kinase 2
    65(a)
    1 ↔ 1
    1(257331131-257405596)
    African clawed frog
    (Xenopus laevis)
    Amphibia vrk2-prov2 vaccinia related kinase 2 76.28(n)    BC041230.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc564832 similar to vaccinia related kinase 2 76.95(n)   394145  BC049319.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta BcDNA:LD090093 protein amino acid phosphorylation
    protein kinase
    41(a)   97D5   --
    worm
    (Caenorhabditis elegans)
    Secernentea F28B12.33 Protein kinase 30(a)   II(5921937-5924423)   --


    ENSEMBL Gene Tree for VRK2 (if available)
    TreeFam Gene Tree for VRK2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for VRK2 gene
    VRK32  VRK12  CSNK1G32  CSNK1D2  ENSG000002593162  CSNK1A12  CSNK1G22  CSNK1A1L2  
    TTBK12  CSNK1E2  CSNK1G12  TTBK22  
    3 SIMAP similar genes for VRK2 using alignment to 4 protein entries:     VRK2_HUMAN (see all proteins):
    VRK1    VRK3    CSNK1E

    Find genes that share paralogs with VRK2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for VRK2 (see all 2383)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1404509491,2
    C--58080053(+) AAAAC-/AAGTTT 7 -- int10--------
    rs587993381,2
    C,F--58081910(+) CACACG/AGTTAA 7 -- int11Minor allele frequency- A:0.15WA 118
    rs602267941,2
    --58082161(+) TGGGGA/GTGGTA 7 -- int10--------
    rs2000975151,2
    --58083775(+) TTTGT-/TTGG  
            
    ACAGA
    7 -- int10--------
    rs1913034831,2
    C--58136900(+) CAGTCC/TATACG 6 -- us2k10--------
    rs1838423241,2
    --58136930(+) GTCCAA/GGTGGC 7 -- us2k10--------
    rs101883901,2
    C,F,A,H--58136995(+) TAGGAC/GATTGG 7 -- us2k113Minor allele frequency- G:0.20NS EA WA NA CSA 788
    rs1391812031,2
    --58137010(+) TGGGAA/GTGCAT 7 -- us2k10--------
    rs1899142621,2
    --58137100(+) ACTTGC/TGTGGG 7 -- us2k10--------
    rs588544491,2
    C,F--58137105(+) TGTGGG/AAGGGA 7 -- us2k11Minor allele frequency- A:0.09WA 118

    HapMap Linkage Disequilibrium report for VRK2 (58134786 - 58384786 bp, first 250kb of VRK2)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for VRK2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1774125CNV Insertion17803354
    nsv527551CNV Loss19592680
    dgv4156n71CNV Loss21882294
    nsv457985CNV Gain19166990
    nsv525988CNV Gain19592680
    nsv834159CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing VRK2
    DNA2.0 Custom Variant and Variant Library Synthesis for VRK2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602169    OMIM disorders: --

    3 diseases for VRK2:    
    About MalaCards
    benign familial infantile epilepsy    vaccinia    schizophrenia

    2 diseases from the University of Copenhagen DISEASES database for VRK2:
    Vaccinia     Benign familial infantile epilepsy

    Find genes that share disorders with VRK2           About GenesLikeMe

    Genetic Association Database (GAD): VRK2
    Human Genome Epidemiology (HuGE) Navigator: VRK2 (1 document)

    Export disorders for VRK2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for VRK2 gene, integrated from 10 sources (see all 43):
    (articles sorted by number of sources associating them with VRK2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Modulation of interleukin-1 transcriptional response by the interaction between VRK2 and the JIP1 scaffold protein. (PubMed id 18286207)1, 2, 9 Blanco S.... Lazo P.A. (PLoS ONE 2008)
    2. Vaccinia-related kinase 2 modulates the stress response to hypoxia mediated by TAK1. (PubMed id 17709393)1, 2, 9 Blanco S.... Lazo P.A. (Mol. Cell. Biol. 2007)
    3. The subcellular localization of vaccinia-related kinase-2 (VRK2) isoforms determines their different effect on p53 stability in tumour cell lines. (PubMed id 16704422)1, 2, 9 Blanco S.... Lazo P.A. (FEBS J. 2006)
    4. Characterization of three paralogous members of the Mammalian vaccinia related kinase family. (PubMed id 14645249)1, 2, 9 Nichols R.J. and Traktman P. (J. Biol. Chem. 2004)
    5. Proteomics identification of nuclear Ran GTPase as an inhibitor of human VRK1 and VRK2 (vaccinia-related kinase) activities. (PubMed id 18617507)1, 2, 9 Sanz-Garcia M.... Lazo P.A. (Mol. Cell. Proteomics 2008)
    6. Human cellular protein VRK2 interacts specifically with Epstein-Barr virus BHRF1, a homologue of Bcl-2, and enhances cell survival. (PubMed id 16963744)1, 2, 9 Li L.Y.... Chen J.Y. (J. Gen. Virol. 2006)
    7. VRK2 inhibits mitogen-activated protein kinase signaling and inversely correlates with ErbB2 in human breast cancer. (PubMed id 20679487)1, 2 Fernandez I.F.... Lazo P.A. (Mol. Cell. Biol. 2010)
    8. Structure of the pseudokinase VRK3 reveals a degraded catalytic site, a highly conserved kinase fold, and a putative regulatory binding site. (PubMed id 19141289)1, 2 Scheeff E.D.... Manning G. (Structure 2009)
    9. Common variants conferring risk of schizophrenia. (PubMed id 19571808)1, 4 Stefansson H....Collier D.A. (Nature 2009)
    10. The vaccinia-related kinases phosphorylate the N' terminus of BAF, regulating its interaction with DNA and its retention in the nucleus. (PubMed id 16495336)1, 2 Nichols R.J.... Traktman P. (Mol. Biol. Cell 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7444 HGNC: 12719 AceView: VRK2 Ensembl:ENSG00000028116 euGenes: HUgn7444
    ECgene: VRK2 H-InvDB: VRK2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for VRK2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for VRK2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for VRK2 gene:
    Search GeneIP for patents involving VRK2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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