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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

VRK2 Gene

protein-coding   GIFtS: 60
GCID: GC02P058185

vaccinia related kinase 2
 Explore 6 diseases affiliated with
VRK2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for VRK2    

Aliases
for VRK2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Vaccinia Related Kinase 21 2
EC 2.7.11.13 8
Serine/Threonine-Protein Kinase VRK22
Vaccinia Virus B1R-Related Kinase 22
Vaccinia-Related Kinase 23

External Ids:    HGNC: 127191   Entrez Gene: 74442   Ensembl: ENSG000000281167   OMIM: 6021695   UniProtKB: Q86Y073   

Export aliases for VRK2 gene to outside databases

Previous GC identifers: GC02P058402 GC02P058092 GC02P058248


Summaries
for VRK2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for VRK2:
This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. This gene
is widely expressed in human tissues and has increased expression in actively dividing cells, such as those in testis,
leukocytes, fetal liver, and carcinomas. Its protein localizes to the endoplasmic reticulum and has been shown to
phosphorylate casein and undergo autophosphorylation. Multiple alternatively spliced transcript variants have been
found for this gene. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: VRK2_HUMAN, Q86Y07
Function: Serine/threonine kinase that regulates several signal transduction pathways. Isoform 1 modulates the stress
response to hypoxia and cytokines, such as interleukin-1 beta (IL1B) and this is dependent on its interaction with
MAPK8IP1, which assembles mitogen-activated protein kinase (MAPK) complexes. Inhibition of signal transmission
mediated by the assembly of MAPK8IP1-MAPK complexes reduces JNK phosphorylation and JUN-dependent transcription.
Phosphorylates 'Thr-18' of p53/TP53, histone H3, and may also phosphorylate MAPK8IP1. Phosphorylates BANF1 and
disrupts its ability to bind DNA and reduces its binding to LEM domain-containing proteins. Downregulates the
transactivation of transcription induced by ERBB2, HRAS, BRAF, and MEK1. Blocks the phosphorylation of ERK in response
to ERBB2 and HRAS. Can also phosphorylate the following substrates that are commonly used to establish in vitro kinase
activity: casein, MBP and histone H2B, but it is not sure that this is physiologically relevant
Function: Isoform 2 phosphorylates 'Thr-18' of p53/TP53, as well as histone H3. Reduces p53/TP53 ubiquitination by
MDM2, promotes p53/TP53 acetylation by EP300 and thereby increases p53/TP53 stability and activity

Gene Wiki entry for VRK2


Genomic Views
for VRK2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.1  NT_022184.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the VRK2 gene promoter:
         Nkx3-1   p53   HNF-4alpha2   E4BP4   HNF-4alpha1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: VRK2 promoter sequence
   Search SABiosciences Chromatin IP Primers for VRK2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat VRK2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p16.1   Ensembl cytogenetic band:  2p16.1   HGNC cytogenetic band: 2p16.1

VRK2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
VRK2 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P058185:  view genomic region     (about GC identifiers)

Start:
 58,134,786 bp from pter      End:
 58,387,055 bp from pter
Size:
 252,270 bases      Orientation:
 plus strand

Proteins
for VRK2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: VRK2_HUMAN, Q86Y07 (See protein sequence)
Recommended Name: Serine/threonine-protein kinase VRK2  
Size: 508 amino acids; 58141 Da
Subunit: Isoform 1 interacts with MAP3K7, MAP2K7, MAP2K1 and KSR1. Isoform 1 and isoform 2 interact with RAN and
MAPK8IP1. Isoform 1 interacts with Epstein-Barr virus BHRF1; this interaction is involved in protecting cells from
apoptosis
Subcellular location: Isoform 1: Cytoplasm. Endoplasmic reticulum membrane; Single-pass type IV membrane protein
(Potential). Mitochondrion membrane; Single-pass type IV membrane protein (Potential)
Subcellular location: Isoform 2: Cytoplasm. Nucleus
Sequence caution: Sequence=CAD54446.2; Type=Miscellaneous discrepancy; Note=Aberrant splicing;
1 PDB 3D structure from and Proteopedia for VRK2:
2V62 (3D)    
Secondary accessions: B4DKL0 D6W5D4 D6W5D6 Q49AK9 Q53EU9 Q53S39 Q53S77 Q53TU1 Q86Y08 Q86Y09 Q86Y10
Q86Y11 Q86Y12 Q8IXI5 Q99987
Alternative splicing: 5 isoforms:  Q86Y07-1   Q86Y07-2   Q86Y07-3   Q86Y07-4   Q86Y07-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for VRK2: NX_Q86Y07

Post-translational modifications:

  • Isoform 1 and isoform 2 are autophosphorylated1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q86Y07

    • 2 DME Specific Peptides for VRK2 (Q86Y07)
     HENEYVHG  EYVHGDIKA 

    VRK2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (5 alternative transcripts): 
    NP_001123952.1  NP_001123953.1  NP_001123954.1  NP_001123955.1  NP_006287.2  

    ENSEMBL proteins: 
     ENSP00000408002   ENSP00000402375   ENSP00000342381   ENSP00000400006   ENSP00000398323  
     ENSP00000404961   ENSP00000404156  
    Reactome Protein details: Q86Y07
    Human Recombinant Protein Products: 
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    Novus Biologicals VRK2 Proteins
    Novus Biologicals VRK2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for VRK2

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005624membrane fraction ----
    GO:0005634nucleus IDA16704422
    GO:0005737cytoplasm IDA16704422
    GO:0005783endoplasmic reticulum ----
    GO:0005789endoplasmic reticulum membrane IDA18286207


    VRK2 for ontologies           About GeneDecksing



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    ThermoFisher Antibodies for VRK2

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    Uscn ELISAs and CLIAs for VRK2

    Protein Domains /
    Families
    for VRK2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    VRK2 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry Q86Y07

    ProtoNet protein and cluster: Q86Y07

    UniProtKB/Swiss-Prot: VRK2_HUMAN, Q86Y07
    Similarity: Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. VRK subfamily
    Similarity: Contains 1 protein kinase domain


    Function
    for VRK2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: VRK2_HUMAN, Q86Y07
    Function: Serine/threonine kinase that regulates several signal transduction pathways. Isoform 1 modulates the stress
    response to hypoxia and cytokines, such as interleukin-1 beta (IL1B) and this is dependent on its interaction with
    MAPK8IP1, which assembles mitogen-activated protein kinase (MAPK) complexes. Inhibition of signal transmission
    mediated by the assembly of MAPK8IP1-MAPK complexes reduces JNK phosphorylation and JUN-dependent transcription.
    Phosphorylates 'Thr-18' of p53/TP53, histone H3, and may also phosphorylate MAPK8IP1. Phosphorylates BANF1 and
    disrupts its ability to bind DNA and reduces its binding to LEM domain-containing proteins. Downregulates the
    transactivation of transcription induced by ERBB2, HRAS, BRAF, and MEK1. Blocks the phosphorylation of ERK in response
    to ERBB2 and HRAS. Can also phosphorylate the following substrates that are commonly used to establish in vitro kinase
    activity: casein, MBP and histone H2B, but it is not sure that this is physiologically relevant
    Function: Isoform 2 phosphorylates 'Thr-18' of p53/TP53, as well as histone H3. Reduces p53/TP53 ubiquitination by
    MDM2, promotes p53/TP53 acetylation by EP300 and thereby increases p53/TP53 stability and activity
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: RAN inhibits its autophosphorylation and its ability to phosphorylate histone H3

         Genatlas biochemistry entry for VRK2:
    vaccinia-related kinase 2,widely expressed

    Enzyme Number (IUBMB): EC 2.7.11.11 2

    miRNA
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    Inhib. RNA
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    Gene Editing
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    Clone
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    Cell Line
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    Search LifeMap BioReagents cell lines for VRK2

    In Situ Assay
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         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VRK2

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004674protein serine/threonine kinase activity IDA14645249
    GO:0005515protein binding IPI18617507
    GO:0005524ATP binding IEA--


    VRK2 for ontologies           About GeneDecksing


    4 GenomeRNAi human phenotypes for VRK2:
     Decreased focal adhesion (FA)   Increased S DNA content  Increased cell death HMECs cel  Synthetic lethal with c-Myc af 


    Pathways & Interactions
    for VRK2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Clearance of Nuclear Envelope Membranes from Chromatin
    		Clearance of Nuclear Envelope Membranes from Chromatin1.00
    		Nuclear Envelope Breakdown0.56
    		Initiation of Nuclear Envelope Reformation0.69
    		Mitotic Prophase0.26
    		Nuclear Envelope Reassembly0.69
    2M Phase
    		M Phase1.00
    		Mitotic Metaphase and Anaphase0.85
    		Mitotic M-M/G1 phases0.88
    		Mitotic Anaphase0.85
    3Cell Cycle
    		Cell Cycle1.00
    		Cell Cycle, Mitotic0.84

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    5/11        Reactome Pathways for VRK2 (see all 11)
        Mitotic Metaphase and Anaphase
    Initiation of Nuclear Envelope Reformation
    Clearance of Nuclear Envelope Membranes from Chromatin
    Mitotic Anaphase
    Cell Cycle



    VRK2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for VRK2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

    5/22 Interacting proteins for VRK2 (Q86Y071, 3 ENSP000003423814) via UniProtKB, MINT, STRING, and/or I2D (see all 22)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RANP628261, 3, ENSP000003961274EBI-1207649,EBI-286642 I2D: score=2 STRING: ENSP00000396127
    KSR1Q8IVT51, 3, ENSP000002687634EBI-1207615,EBI-486984 I2D: score=1 STRING: ENSP00000268763
    MAP2K1Q027501, 3, ENSP000003024864EBI-1207615,EBI-492564 I2D: score=1 STRING: ENSP00000302486
    BCL2P104153, ENSP000003296234I2D: score=2 STRING: ENSP00000329623
    MAP3K7O433183, ENSP000003583354I2D: score=2 STRING: ENSP00000358335
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation TAS9344656
    GO:0006979response to oxidative stress ----
    GO:0019048virus-host interaction IEA--
    GO:0034599cellular response to oxidative stress IMP17709393
    GO:0043408regulation of MAPK cascade IMP--


    VRK2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for VRK2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
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    Browse Tocris compounds for VRK2

    2 HMDB Compounds for VRK2    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Search CenterWatch for drugs/clinical trials and news about VRK2 

    Transcripts
    for VRK2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for VRK2 gene (5 alternative transcripts): 
    NM_001130480.2  NM_001130481.2  NM_001130482.2  NM_001130483.2  NM_006296.6  

    Unigene Cluster for VRK2:

    Vaccinia related kinase 2
    Hs.744058  [show with all ESTs]
    Unigene Representative Sequence: NR_036441
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000435505(uc002rzo.2) ENST00000417641(uc010fcb.2) ENST00000478687
    ENST00000463222 ENST00000340157 ENST00000432057 ENST00000440705(uc010yph.1)
    ENST00000428021 ENST00000412104(uc002rzt.3 uc002rzs.3 uc002rzv.3 uc010fcd.3 uc002rzu.3 uc010fcc.3 uc002rzp.3 uc010ypg.2)


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    Inhib. RNA
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    Clone
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    Additional cDNA sequence: 

    AB000450.1 AJ512204.2 AK058199.1 AK223540.1 AK295193.1 AK296611.1 AK311205.1 AY228367.1 
    AY228368.1 AY228369.1 AY228372.1 BC021663.1 BC027854.1 NR_036441.1 NR_049781.1 

    13 DOTS entries:

    DT.100783920  DT.95279769  DT.100689663  DT.100026572  DT.120965339  DT.91741724  DT.100719312  DT.40128903 
    DT.100783921  DT.92440951  DT.95279772  DT.75182666  DT.100783923 

    24/158 AceView cDNA sequences (see all 158):

    NM_006296 AL036075 BG576907 AA641955 AI338025 AY228367 CA418927 AA617933 
    AL603006 AI383951 BF754743 CA432823 AI249475 AL046040 CR624256 AY228370 
    AY228372 BM997500 BC027854 AA282292 BX094979 CD365181 H67557 BC036434 

    GeneLoc Exon Structure


    Expression
    for VRK2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    VRK2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GAAAGTGCAG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    VRK2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BrainCerebral CortexBrain
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See VRK2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for VRK2

    SOURCE GeneReport for Unigene cluster: Hs.744058

    UniProtKB/Swiss-Prot: VRK2_HUMAN, Q86Y07
    Tissue specificity: Isoform 1 and isoform 2 are expressed in various tumor cell lines. Expression of isoform 1
    inversely correlates with ERBB2 in breast carcinomas (at protein level). Widely expressed. Highly expressed in fetal
    liver, skeletal muscle, pancreas, heart, peripheral blood leukocytes and testis

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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VRK2

    Orthologs
    for VRK2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for VRK2 gene from 8/24 species (see all 24)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves LOC1008571441 serine/threonine-protein kinase VRK2-like 65.14(n)
    57.17(a)    		   100857144  XM_003640879.1  XP_003640927.1 
    lizard
    (Anolis carolinensis)    		 Reptilia VRK26
    		 --
    		 65(a)
    		 1 ↔ 1
    		 1(257331131-257368894)
    African clawed frog
    (Xenopus laevis)    		 Amphibia vrk2-prov2 vaccinia related kinase 2 76.28(n)    BC041230.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii zgc564832 similar to vaccinia related kinase 2 76.95(n)   394145  BC049319.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta BcDNA:LD090093 protein amino acid phosphorylation protein
    kinase    		 41(a)   97D5   --
    worm
    (Caenorhabditis elegans)    		 Secernentea F28B12.33 Protein kinase 30(a)   II(5921937-5924423)   --
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT3G039306
    AT5G181906
    (see all 5)    		 protein kinase-like protein
    (see all 5)    		 4(a)
    11(a)
    (see all 5)    		 many ↔ many
    many ↔ many
    (see all 5)    		 3(1011414-1012810)
    5(6009967-6014689)
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    (see all 6)    		 CK1_CaseinKinase_1a.1 - CK1 includes the casein ki...
    CK1_CaseinKinase_1a.5 - CK1 includes the casein ki...
    (see all 6)    		 12(a)
    12(a)
    (see all 6)    		 many ↔ many
    many ↔ many
    (see all 6)    		 1(5327818-5334518)
    5(6272625-6282505)


    ENSEMBL Gene Tree for VRK2 (if available)
    TreeFam Gene Tree for VRK2 (if available) 

    Paralogs
    for VRK2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for VRK2 gene
    VRK32  VRK12  CSNK1G32  CSNK1D2  CSNK1G22  CSNK1A12  CSNK1A1L2  TTBK12  
    CSNK1G12  CSNK1E2  TTBK22  
    3 SIMAP similar genes for VRK2 using alignment to 4 protein entries:     VRK2_HUMAN (see all proteins):
    VRK1    VRK3    CSNK1E

    VRK2 for paralogs           About GeneDecksing



    Genomic Variants
    for VRK2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1878 NCBI SNPs in VRK2 are shown (see all 1878)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 2 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs101883901,2
    		C,F,A,H,--58013030(+) TAGGAC/GATTGG 7 -- us2k113Minor allele frequency- G:0.20NS EA WA NA CSA 788
    rs588544491,2
    		C,F,--58013140(+) TGTGGG/AAGGGA 7 -- us2k11Minor allele frequency- A:0.09WA 118
    rs1815710391,2
    		C,--58013170(+) TACTGA/CTAAAT 7 -- us2k10--------
    rs592643901,2
    		C,--58013208(+) TCTCAA/GTCCTC 7 -- us2k12Minor allele frequency- G:0.15WA 120
    rs728103181,2
    		C,--58013510(+) TGCTGG/AATGTA 7 -- us2k14Minor allele frequency- A:0.09NA WA EA 360
    rs1133114291,2
    		C,--58013604(+) GTTGCT/CACTGG 7 -- us2k12Minor allele frequency- C:0.02WA 120
    rs76019691,2
    		C,F,A,H,--58013700(+) TTAGGA/TTTATT 7 -- us2k16Minor allele frequency- T:0.03NS EA WA 526
    rs9688501,2
    		C,--58014107(+) GTTTCC/GCTCTT 7 -- us2k1 trp33Minor allele frequency- G:0.10NA EA 242
    rs116880781,2
    		C,F,H,--58015099(+) GAGGCC/TCGGTC 7 -- int1 ut51 nc-transcript-variant9Minor allele frequency- T:0.05NS EA NA 1074
    rs795548171,2
    		--58015562(+) GGTACC/GAGTTT 7 -- int10--------

    HapMap Linkage Disequilibrium report for VRK2 (58134786 - 58384786 bp, first 250kb of VRK2)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for VRK2
         1 CNV: 89677

    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for VRK2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    VRK2 for disorders           About GeneDecksing

    OMIM gene information: 602169    OMIM disorders: --

    6 diseases for VRK2:    About MalaCards
    vaccinia    carcinoma    breast carcinoma    breast cancer
    hypoxia    schizophrenia

    1 disease from the University of Copenhagen DISEASES database for VRK2:
    Vaccinia
    Human Genome Epidemiology (HuGE) Navigator: VRK2 (1 document)

    Export disorders for VRK2 gene to outside databases

    Publications
    for VRK2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for VRK2 gene, integrated from 9 sources (see all 31):
    (articles sorted by number of sources associating them with VRK2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Modulation of interleukin-1 transcriptional response by the interaction between VRK2 and the JIP1 scaffold protein. (PubMed id 18286207)1, 2, 9 Blanco S....Lazo P.A. (2008)
    2. Vaccinia-related kinase 2 modulates the stress response to hypoxia mediated by TAK1. (PubMed id 17709393)1, 2, 9 Blanco S....Lazo P.A. (2007)
    3. The subcellular localization of vaccinia-related kinase-2 (VRK2) isoforms determines their different effect on p53 stability in tumour cell lines. (PubMed id 16704422)1, 2, 9 Blanco S....Lazo P.A. (2006)
    4. Characterization of three paralogous members of the Mammalian vaccinia related kinase family. (PubMed id 14645249)1, 2, 9 Nichols R.J. and Traktman P. (2004)
    5. Proteomics identification of nuclear Ran GTPase as an inhibitor of human VRK1 and VRK2 (vaccinia-related kinase) activities. (PubMed id 18617507)1, 2, 9 Sanz-Garcia M....Lazo P.A. (2008)
    6. Human cellular protein VRK2 interacts specifically with Epstein-Barr virus BHRF1, a homologue of Bcl-2, and enhances cell survival. (PubMed id 16963744)1, 2, 9 Li L.Y....Chen J.Y. (2006)
    7. VRK2 inhibits mitogen-activated protein kinase signal ing and inversely correlates with ErbB2 in human breast cancer. (PubMed id 20679487)1, 2 FernA!ndez I.F....Lazo P.A. (2010)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. Identification of two novel human putative serine/threonine kinases, VRK1 and VRK2, with structural similarity to Vaccinia virus B1R kinase. (PubMed id 9344656)1, 2 Nezu J.... Shimane M. (1997)
    10. Human VRK2 (vaccinia-related kinase 2) modulates tumor cell invasion by hyperactivation of NFAT1 and expression of cyclooxygenase-2. (PubMed id 23105117)1 Vazquez-Cedeira M. and Lazo P.A. (2012)

    External Searches for VRK2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing VRK2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7444 HGNC: 12719 AceView: VRK2 Ensembl:ENSG00000028116 euGenes: HUgn7444
    ECgene: VRK2 H-InvDB: VRK2

    Other Databases showing VRK2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing VRK2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for VRK2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for VRK2 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for VRK2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for VRK2 gene:
    Search GeneIP for patents involving VRK2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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