Aliases for VPS8 Gene
External Ids for VPS8 Gene
Previous HGNC Symbols for VPS8 Gene
Previous GeneCards Identifiers for VPS8 Gene
GeneCards Summary for VPS8 Gene
VPS8 (VPS8, CORVET Complex Subunit) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include binding.
UniProtKB/Swiss-Prot for VPS8 Gene
Plays a role in vesicle-mediated protein trafficking of the endocytic membrane transport pathway. Believed to act as a component of the putative CORVET endosomal tethering complexes which is proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations (PubMed:25266290). Functions predominantly in APPL1-containing endosomes (PubMed:25266290).