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Aliases for VPS8 Gene

Aliases for VPS8 Gene

  • VPS8, CORVET Complex Subunit 2 3 5
  • KIAA0804 2 3 4
  • Vacuolar Protein Sorting 8 Homolog (S. Cerevisiae) 2
  • Vacuolar Protein Sorting 8 Homolog 3
  • VPS8 CORVET Complex Subunit 3

External Ids for VPS8 Gene

Previous HGNC Symbols for VPS8 Gene

  • KIAA0804

Previous GeneCards Identifiers for VPS8 Gene

  • GC03P186012
  • GC03P184529
  • GC03P181939

Summaries for VPS8 Gene

GeneCards Summary for VPS8 Gene

VPS8 (VPS8, CORVET Complex Subunit) is a Protein Coding gene. GO annotations related to this gene include binding.

UniProtKB/Swiss-Prot for VPS8 Gene

  • Plays a role in vesicle-mediated protein trafficking of the endocytic membrane transport pathway. Believed to act as a component of the putative CORVET endosomal tethering complexes which is proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations (PubMed:25266290). Functions predominantly in APPL1-containing endosomes (PubMed:25266290).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VPS8 Gene

Genomics for VPS8 Gene

Regulatory Elements for VPS8 Gene

Enhancers for VPS8 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around VPS8 on UCSC Golden Path with GeneCards custom track

Promoters for VPS8 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around VPS8 on UCSC Golden Path with GeneCards custom track

Genomic Location for VPS8 Gene

Chromosome:
3
Start:
184,812,137 bp from pter
End:
185,052,614 bp from pter
Size:
240,478 bases
Orientation:
Plus strand

Genomic View for VPS8 Gene

Genes around VPS8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
VPS8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for VPS8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VPS8 Gene

Proteins for VPS8 Gene

  • Protein details for VPS8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N3P4-VPS8_HUMAN
    Recommended name:
    Vacuolar protein sorting-associated protein 8 homolog
    Protein Accession:
    Q8N3P4
    Secondary Accessions:
    • A8K8Q8
    • B9EIQ1
    • C9JB61
    • O94896
    • Q63HP2
    • Q9BVP9
    • Q9H9B0

    Protein attributes for VPS8 Gene

    Size:
    1428 amino acids
    Molecular mass:
    161754 Da
    Quaternary structure:
    • Interacts with RAB5C (By similarity). Interacts with TGFBRAP1 (PubMed:25266290). Component of the putative class C core vacuaole/endosome tethering (CORVET) complex; the core of which composed of the class C Vps proteins VPS11, VPS16, VPS18 and VPS33A, is associated with VPS8 and TGFBRAP1 (PubMed:25266290).
    SequenceCaution:
    • Sequence=BAB14322.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAH56195.1; Type=Frameshift; Positions=325; Evidence={ECO:0000305};

    Alternative splice isoforms for VPS8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for VPS8 Gene

Proteomics data for VPS8 Gene at MOPED

Post-translational modifications for VPS8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for VPS8 Gene

Domains & Families for VPS8 Gene

Suggested Antigen Peptide Sequences for VPS8 Gene

Graphical View of Domain Structure for InterPro Entry

Q8N3P4

UniProtKB/Swiss-Prot:

VPS8_HUMAN :
  • Belongs to the VPS8 family.
  • Contains 1 RING-type zinc finger.
Family:
  • Belongs to the VPS8 family.
Similarity:
  • Contains 1 RING-type zinc finger.
  • Contains 1 WD repeat.
genes like me logo Genes that share domains with VPS8: view

No data available for Gene Families for VPS8 Gene

Function for VPS8 Gene

Molecular function for VPS8 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in vesicle-mediated protein trafficking of the endocytic membrane transport pathway. Believed to act as a component of the putative CORVET endosomal tethering complexes which is proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations (PubMed:25266290). Functions predominantly in APPL1-containing endosomes (PubMed:25266290).
genes like me logo Genes that share phenotypes with VPS8: view

Animal Model Products

miRNA for VPS8 Gene

miRTarBase miRNAs that target VPS8

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for VPS8 Gene

Localization for VPS8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for VPS8 Gene

Early endosome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for VPS8 Gene COMPARTMENTS Subcellular localization image for VPS8 gene
Compartment Confidence
endosome 5
cytosol 3
golgi apparatus 2
nucleus 2
plasma membrane 2
vacuole 2
cytoskeleton 1
extracellular 1
lysosome 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for VPS8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005769 early endosome IDA 25266290
genes like me logo Genes that share ontologies with VPS8: view

Pathways & Interactions for VPS8 Gene

SuperPathways for VPS8 Gene

No Data Available

Interacting Proteins for VPS8 Gene

Selected Interacting proteins: Q8N3P4-VPS8_HUMAN for VPS8 Gene via MINT I2D UniProtKB

Gene Ontology (GO) - Biological Process for VPS8 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for VPS8 Gene

Drugs & Compounds for VPS8 Gene

No Compound Related Data Available

Transcripts for VPS8 Gene

Unigene Clusters for VPS8 Gene

Vacuolar protein sorting 8 homolog (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for VPS8 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^
SP1: - - -
SP2:
SP3: - -
SP4: - -
SP5: -
SP6:
SP7:
SP8:
SP9: -
SP10:

ExUns: 20a · 20b ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27a · 27b ^ 28a · 28b ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35 ^ 36 ^ 37 ^ 38 ^ 39 ^ 40 ^ 41 ^ 42 ^
SP1: - - -
SP2: -
SP3:
SP4:
SP5: - -
SP6:
SP7:
SP8: - -
SP9:
SP10:

ExUns: 43 ^ 44 ^ 45 ^ 46 ^ 47
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for VPS8 Gene

GeneLoc Exon Structure for
VPS8
ECgene alternative splicing isoforms for
VPS8

Expression for VPS8 Gene

mRNA expression in normal human tissues for VPS8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for VPS8 Gene

This gene is overexpressed in Lymph node (12.2), Frontal cortex (7.0), and Placenta (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for VPS8 Gene



SOURCE GeneReport for Unigene cluster for VPS8 Gene Hs.269263

genes like me logo Genes that share expression patterns with VPS8: view

Protein tissue co-expression partners for VPS8 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for VPS8 Gene

Orthologs for VPS8 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for VPS8 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia VPS8 35
  • 92.85 (n)
  • 96.21 (a)
VPS8 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia VPS8 35
  • 93.6 (n)
  • 97.27 (a)
VPS8 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Vps8 35
  • 85.86 (n)
  • 93.55 (a)
Vps8 16
Vps8 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia VPS8 35
  • 98.9 (n)
  • 98.81 (a)
VPS8 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Vps8 35
  • 85.67 (n)
  • 93.84 (a)
oppossum
(Monodelphis domestica)
Mammalia VPS8 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 76 (a)
OneToMany
-- 36
  • 90 (a)
OneToMany
-- 36
  • 90 (a)
OneToMany
-- 36
  • 90 (a)
OneToMany
-- 36
  • 71 (a)
OneToMany
-- 36
  • 80 (a)
OneToMany
-- 36
  • 92 (a)
OneToMany
chicken
(Gallus gallus)
Aves VPS8 35
  • 76.92 (n)
  • 84.33 (a)
VPS8 36
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia VPS8 36
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.17234 35
vps8 35
  • 70.75 (n)
  • 76.67 (a)
zebrafish
(Danio rerio)
Actinopterygii vps8 35
  • 67.52 (n)
  • 70.63 (a)
vps8 36
  • 69 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007578 35
  • 44.2 (n)
  • 36.93 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10144 35
  • 46.85 (n)
  • 36.44 (a)
CG10144 36
  • 34 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea C42C1.4 35
  • 42.4 (n)
  • 27.19 (a)
C42C1.4 36
  • 22 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes VPS8 36
  • 18 (a)
OneToOne
VPS8 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G00800 35
  • 44.71 (n)
  • 30.72 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 43 (a)
OneToOne
Species with no ortholog for VPS8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for VPS8 Gene

ENSEMBL:
Gene Tree for VPS8 (if available)
TreeFam:
Gene Tree for VPS8 (if available)

Paralogs for VPS8 Gene

No data available for Paralogs for VPS8 Gene

Variants for VPS8 Gene

Sequence variations from dbSNP and Humsavar for VPS8 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs9830734 - 184,832,713(+) CTTTT(A/G)TTCTT nc-transcript-variant, reference, missense
rs11555405 - 184,982,638(+) ATCTA(C/T)ACTCT reference, missense
rs3821750 - 185,048,513(+) GCAAA(C/T)CCAAG reference, missense
rs16859527 - 185,048,537(+) TTGCC(A/G)TCTCT reference, missense
rs3332 -- 185,052,592(-) AACAC(A/G)GAGCA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for VPS8 Gene

Variant ID Type Subtype PubMed ID
nsv520816 CNV Gain 19592680
esv2643797 CNV Insertion 19546169
esv2726320 CNV Deletion 23290073
esv2661930 CNV Deletion 23128226
esv26122 CNV Gain 19812545

Variation tolerance for VPS8 Gene

Residual Variation Intolerance Score: 72% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.84; 91.76% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for VPS8 Gene

HapMap Linkage Disequilibrium report
VPS8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VPS8 Gene

Disorders for VPS8 Gene

Relevant External Links for VPS8

Genetic Association Database (GAD)
VPS8
Human Genome Epidemiology (HuGE) Navigator
VPS8
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
VPS8

No disorders were found for VPS8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for VPS8 Gene

Publications for VPS8 Gene

  1. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9872452) Nagase T. … Ohara O. (DNA Res. 1998) 2 3 4 67
  2. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  5. Mammalian CORVET is required for fusion and conversion of distinct early endosome subpopulations. (PMID: 25266290) Perini E.D. … Zerial M. (Traffic 2014) 3

Products for VPS8 Gene

Sources for VPS8 Gene

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