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Aliases for VPS8 Gene

Aliases for VPS8 Gene

  • Vacuolar Protein Sorting 8 Homolog (S. Cerevisiae) 2 3
  • KIAA0804 2 3 4
  • Vacuolar Protein Sorting-Associated Protein 8 Homolog 3

External Ids for VPS8 Gene

Previous Symbols for VPS8 Gene

  • KIAA0804

Summaries for VPS8 Gene

GeneCards Summary for VPS8 Gene

VPS8 (Vacuolar Protein Sorting 8 Homolog (S. Cerevisiae)) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VPS8 Gene

Genomics for VPS8 Gene

Genomic Location for VPS8 Gene

Start:
184,812,137 bp from pter
End:
185,052,614 bp from pter
Size:
240,478 bases
Orientation:
Plus strand

Genomic View for VPS8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for VPS8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VPS8 Gene

Regulatory Elements for VPS8 Gene

Proteins for VPS8 Gene

  • Protein details for VPS8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N3P4-VPS8_HUMAN
    Recommended name:
    Vacuolar protein sorting-associated protein 8 homolog
    Protein Accession:
    Q8N3P4
    Secondary Accessions:
    • A8K8Q8
    • B9EIQ1
    • C9JB61
    • O94896
    • Q63HP2
    • Q9BVP9
    • Q9H9B0

    Protein attributes for VPS8 Gene

    Size:
    1428 amino acids
    Molecular mass:
    161754 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB14322.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAH56195.1; Type=Frameshift; Positions=325; Evidence={ECO:0000305};

    Alternative splice isoforms for VPS8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for VPS8 Gene

Proteomics data for VPS8 Gene at MOPED

Post-translational modifications for VPS8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for VPS8 Gene

Domains for VPS8 Gene

UniProtKB/Swiss-Prot:

VPS8_HUMAN
Family:
  • Belongs to the VPS8 family.:
    • Q8N3P4
Similarity:
  • Contains 1 RING-type zinc finger.:
    • Q8N3P4
  • Contains 1 WD repeat.:
    • Q8N3P4
genes like me logo Genes that share domains with VPS8: view

No data available for Gene Families for VPS8 Gene

Function for VPS8 Gene

Gene Ontology (GO) - Molecular Function for VPS8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005488 binding --
GO:0005515 protein binding --
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with VPS8: view

Phenotypes for VPS8 Gene

GenomeRNAi human phenotypes for VPS8:
genes like me logo Genes that share phenotypes with VPS8: view

miRNA for VPS8 Gene

miRTarBase miRNAs that target VPS8

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for VPS8 Gene

Localization for VPS8 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for VPS8 Gene COMPARTMENTS Subcellular localization image for VPS8 gene
Compartment Confidence
cytosol 2
endosome 2
lysosome 2
nucleus 2
vacuole 2
cytoskeleton 1
extracellular 1
mitochondrion 1
peroxisome 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for VPS8 Gene

Pathways for VPS8 Gene

SuperPathways for VPS8 Gene

No Data Available

Interacting Proteins for VPS8 Gene

Selected Interacting proteins: Q8N3P4-VPS8_HUMAN for VPS8 Gene via MINT I2D

Symbol External ID(s) Details
SMAD9

Gene Ontology (GO) - Biological Process for VPS8 Gene

None

No data available for Pathways by source for VPS8 Gene

Transcripts for VPS8 Gene

Unigene Clusters for VPS8 Gene

Vacuolar protein sorting 8 homolog (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for VPS8 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^
SP1: - - -
SP2:
SP3: - -
SP4: - -
SP5: -
SP6:
SP7:
SP8:
SP9: -
SP10:

ExUns: 20a · 20b ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27a · 27b ^ 28a · 28b ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35 ^ 36 ^ 37 ^ 38 ^ 39 ^ 40 ^ 41 ^ 42 ^
SP1: - - -
SP2: -
SP3:
SP4:
SP5: - -
SP6:
SP7:
SP8: - -
SP9:
SP10:

ExUns: 43 ^ 44 ^ 45 ^ 46 ^ 47
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for VPS8 Gene

GeneLoc Exon Structure for
VPS8
ECgene alternative splicing isoforms for
VPS8

Expression for VPS8 Gene

mRNA expression in normal human tissues for VPS8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for VPS8 Gene

SOURCE GeneReport for Unigene cluster for VPS8 Gene Hs.269263

genes like me logo Genes that share expressions with VPS8: view

Orthologs for VPS8 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for VPS8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia VPS8 36
  • 98.9 (n)
  • 98.81 (a)
VPS8 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia VPS8 36
  • 92.85 (n)
  • 96.21 (a)
VPS8 37
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia VPS8 36
  • 93.6 (n)
  • 97.27 (a)
VPS8 37
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Vps8 36
  • 85.86 (n)
  • 93.55 (a)
Vps8 16
Vps8 37
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia VPS8 37
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 76 (a)
OneToMany
-- 37
  • 90 (a)
OneToMany
-- 37
  • 90 (a)
OneToMany
-- 37
  • 90 (a)
OneToMany
-- 37
  • 71 (a)
OneToMany
-- 37
  • 80 (a)
OneToMany
-- 37
  • 92 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Vps8 36
  • 85.67 (n)
  • 93.84 (a)
chicken
(Gallus gallus)
Aves VPS8 36
  • 76.92 (n)
  • 84.33 (a)
VPS8 37
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia VPS8 37
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.17234 36
vps8 36
  • 70.75 (n)
  • 76.67 (a)
zebrafish
(Danio rerio)
Actinopterygii vps8 36
  • 67.52 (n)
  • 70.63 (a)
vps8 37
  • 69 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007578 36
  • 44.2 (n)
  • 36.93 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10144 36
  • 46.85 (n)
  • 36.44 (a)
CG10144 37
  • 34 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea C42C1.4 36
  • 42.4 (n)
  • 27.19 (a)
C42C1.4 37
  • 22 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes VPS8 37
  • 18 (a)
OneToOne
VPS8 39
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G00800 36
  • 44.71 (n)
  • 30.72 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 43 (a)
OneToOne
Species with no ortholog for VPS8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for VPS8 Gene

ENSEMBL:
Gene Tree for VPS8 (if available)
TreeFam:
Gene Tree for VPS8 (if available)

Paralogs for VPS8 Gene

No data available for Paralogs for VPS8 Gene

Variants for VPS8 Gene

Sequence variations from dbSNP and Humsavar for VPS8 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs3332 -- 185,052,592(-) AACAC(A/G)GAGCA utr-variant-3-prime
rs716561 -- 185,005,975(-) cctga(C/G)aactg intron-variant
rs716641 -- 185,005,913(-) CTGGC(C/T)ACAGC intron-variant
rs721432 -- 184,966,241(+) GGGAG(A/G)CGTCA intron-variant
rs724273 -- 184,858,043(-) TAAGT(C/T)ACCTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for VPS8 Gene

Variant ID Type Subtype PubMed ID
nsv520816 CNV Gain 19592680
esv2643797 CNV Insertion 19546169
esv2726320 CNV Deletion 23290073
esv2661930 CNV Deletion 23128226
esv26122 CNV Gain 19812545

Relevant External Links for VPS8 Gene

HapMap Linkage Disequilibrium report
VPS8

Disorders for VPS8 Gene

Relevant External Links for VPS8

Genetic Association Database (GAD)
VPS8
Human Genome Epidemiology (HuGE) Navigator
VPS8
genes like me logo Genes that share disorders with VPS8: view

No data available for UniProtKB/Swiss-Prot for VPS8 Gene

Publications for VPS8 Gene

  1. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9872452) Nagase T. … Ohara O. (DNA Res. 1998) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 49
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for VPS8 Gene

Sources for VPS8 Gene

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