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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

VPS8 Gene

protein-coding   GIFtS: 47
GCID: GC03P184529

vacuolar protein sorting 8 homolog (S. cerevisiae)

(Previous name: KIAA0804 )
(Previous symbol: KIAA0804)
  Search for VPS8
in our new
 Human Malady Compendium 
Biological research products
for VPS8
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Vacuolar Protein Sorting 8 Homolog (S. Cerevisiae)1 2
KIAA08041 2 3
FLJ320991
Vacuolar Protein Sorting-Associated Protein 8 Homolog2

External Ids:    HGNC: 291221   Entrez Gene: 233552   Ensembl: ENSG000001569317   UniProtKB: Q8N3P43   

Export aliases for VPS8 gene to outside databases

Previous GC identifers: GC03P186012 GC03P181939


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

  --

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.1  NT_005612.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the VPS8 gene promoter:
         ER-alpha   NF-1/L   NF-1   USF1   AML1a   HSF1 (long)   Evi-1   AREB6   USF-1   HSF1short   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidVPS8 promoter sequence
   Search SABiosciences Chromatin IP Primers for VPS8

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat VPS8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q27.2   Ensembl cytogenetic band:  3q27.2   HGNC cytogenetic band: 3q27.2

VPS8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
VPS8 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P184529:  view genomic region     (about GC identifiers)

Start:
184,529,931 bp from pter      End:
184,770,402 bp from pter
Size:
240,472 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: VPS8_HUMAN, Q8N3P4 (See protein sequence)
Recommended Name: Vacuolar protein sorting-associated protein 8 homolog  
Size: 1428 amino acids; 161754 Da
Sequence caution: Sequence=BAB14322.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=CAH56195.1; Type=Frameshift; Positions=325;
Secondary accessions: A8K8Q8 B9EIQ1 C9JB61 O94896 Q63HP2 Q9BVP9 Q9H9B0
Alternative splicing: 3 isoforms:  Q8N3P4-1   Q8N3P4-2   Q8N3P4-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for VPS8: NX_Q8N3P4

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8N3P4

  • VPS8 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001009921.1  NP_056118.2  

    ENSEMBL proteins: 
     ENSP00000404704   ENSP00000405483   ENSP00000415161   ENSP00000389480   ENSP00000394018  
     ENSP00000409957   ENSP00000416150   ENSP00000397553   ENSP00000413778   ENSP00000416101  
     ENSP00000409115   ENSP00000400267   ENSP00000393070   ENSP00000287546   ENSP00000397879  

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    Uscn Proteins for VPS8


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    Uscn ELISAs and CLIAs for VPS8


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    VPS8 for domains           About GeneDecksing

    5/7 InterPro domains/families (see all 7):
     IPR001841 Znf_RING
     IPR001680 WD40_repeat
     IPR017986 WD40_repeat_dom
     IPR013083 Znf_RING/FYVE/PHD
     IPR015943 WD40/YVTN_repeat-like_dom

    Graphical View of Domain Structure for InterPro Entry Q8N3P4

    ProtoNet protein and cluster: Q8N3P4

    1 Blocks protein family: IPB001841 Zn-finger

    UniProtKB/Swiss-Prot: VPS8_HUMAN, Q8N3P4
    Similarity: Belongs to the VPS8 family
    Similarity: Contains 1 RING-type zinc finger
    Similarity: Contains 1 WD repeat


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    miRNA
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    OriGene 3'-UTR Clone (see all 2): VPS8
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat VPS8
    1 QIAGEN miScript miRNA Assays for microRNA that regulate VPS8:
    hsa-miR-4299
    SwitchGear 3'UTR luciferase reporter plasmidVPS8 3' UTR sequence
    Inhib. RNA
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VPS8

    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008270zinc ion binding IEA--


    VPS8 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for VPS8:
     Synthetic lethal with c-Myc af 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for VPS8

    1 Interacting protein for VPS8 (Q8N3P42, 3) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMAD9O151982, 3MINT-62119 I2D: score=3 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for VPS8
    Search CenterWatch for drugs/clinical trials and news about VPS8 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for VPS8 gene (2 alternative transcripts): 
    NM_001009921.2  NM_015303.3  

    Unigene Cluster for VPS8:

    Vacuolar protein sorting 8 homolog (S. cerevisiae)
    Hs.269263  [show with all ESTs]
    Unigene Representative Sequence: NM_001009921
    18/27 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 27):
    ENST00000436792 ENST00000446204 ENST00000422105 ENST00000485024 ENST00000424463(uc003fpc.1)
    ENST00000453056 ENST00000475580 ENST00000471655 ENST00000441141 ENST00000445089
    ENST00000424721 ENST00000452666 ENST00000469479 ENST00000460158 ENST00000426319
    ENST00000465818 ENST00000469713 ENST00000465213

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat VPS8
    1 QIAGEN miScript miRNA Assays for microRNA that regulate VPS8:
    hsa-miR-4299
    SwitchGear 3'UTR luciferase reporter plasmidVPS8 3' UTR sequence
    Inhib. RNA
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    Browse OriGene siRNA
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    Clone
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): VPS8 (NM_001009921)
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat VPS8
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat VPS8

    Additional cDNA sequence: 

    AB018347.1 AK022945.1 AK056661.1 AK292423.1 AK308728.1 AK309244.1 AL833838.1 BC001001.2 
    BC036005.2 BC140768.1 BX647915.1 EF491783.1 

    18 DOTS entries:

    DT.442049  DT.91966198  DT.100785984  DT.75117873  DT.100785987  DT.100785986  DT.100785988  DT.92432587 
    DT.102829069  DT.120889741  DT.120889763  DT.40122902  DT.92432582  DT.40307128  DT.91696963  DT.91839422 
    DT.92014480  DT.95204422 

    24/172 AceView cDNA sequences (see all 172):

    BF477446 AW075950 CB054927 BX510130 BE018468 BC001001 AL041074 BM723581 
    CA439534 AB018347 CA307353 AW517528 AL703904 AW189474 AW301686 AI089931 
    BE221999 AI086238 BF432593 CB127462 AW273420 BC036005 BE858275 BQ478434 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for VPS8 (see all 10)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^
    SP1:                                                                                                              -                             -     -         
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                            -     -         
    SP4:                          -           -                                                                                                                     
    SP5:                                                                                                                                                  -         

    ExUns: 20a · 20b ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27a · 27b ^ 28a · 28b ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35 ^ 36 ^ 37 ^ 38 ^ 39 ^ 40 ^ 41 ^ 42 ^
    SP1:  -     -                       -                                                                                                                           
    SP2:                                -                                                                                                                           
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:  -     -                                                                                                                                                   

    ExUns: 43 ^ 44 ^ 45 ^ 46 ^ 47
    SP1:                              
    SP2:                              
    SP3:                              
    SP4:                              
    SP5:                              


    ECgene alternative splicing isoforms for VPS8

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    VPS8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTAAAACCTA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See VPS8 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for VPS8

    SOURCE GeneReport for Unigene cluster: Hs.269263
        SABiosciences Expression via Pathway-Focused PCR Array including VPS8: 
              Ubiquitin Ligases in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VPS8

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for VPS8 gene from 9/27 species (see all 27)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Vps81 , 5 vacuolar protein sorting 8 homolog (S. cerevisiae)1, 5 85.88(n)1
    93.56(a)1
      16 (12.69 cM)5
    2090181  NM_001081366.11  NP_001074835.11 
     214231185 
    chicken
    (Gallus gallus)
    Aves VPS81 vacuolar protein sorting 8 homolog (S. cerevisiae) 76.85(n)
    84.18(a)
      429138  XM_426694.3  XP_426694.3 
    lizard
    (Anolis carolinensis)
    Reptilia VPS86
    --
    81(a)
    1 ↔ 1
    3(34617997-34753512)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.172342 Transcribed sequence with weak similarity to protein more 75.25(n)    AL849266.2 
    zebrafish
    (Danio rerio)
    Actinopterygii BQ784038.12   -- 75.03(n)    BQ784038.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG101441 CG10144 46.14(n)
    35.57(a)
      38735  NM_139791.2  NP_648048.1 
    worm
    (Caenorhabditis elegans)
    Secernentea C42C1.41 Protein C42C1.4 42.13(n)
    26.57(a)
      178174  NM_001027888.3  NP_001023059.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT4G008001 transducin family protein / WD-40 repeat family protein 44.56(n)
    30.19(a)
      828005  NM_116306.6  NP_567189.6 
    rice
    (Oryza sativa)
    Liliopsida --
    protein binding protein, putative, expressed
    19(a)
    1 ↔ 1
    2(1283155-1288182)


    ENSEMBL Gene Tree for VPS8 (if available)
    TreeFam Gene Tree for VPS8 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3522 NCBI SNPs in VPS8 are shown (see all 3522    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs343596961,2
    C,--181939126(+) TGTTAG/TGTCTG 1 -- us2k10--------
    rs1119463041,2
    --181939692(+) CCTTCC/TGGGCT 1 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs168592991,2
    C,F,H,--181939775(+) TGCGCT/CACTCT 1 -- us2k111Minor allele frequency- C:0.06NA NS WA 1056
    rs738881721,2
    C,--181939839(+) TAGGGG/CGGAAG 1 -- us2k11Minor allele frequency- C:0.50WA 2
    rs622869311,2
    --181940096(+) AGGGTC/AGGAGG 1 -- us2k11Minor allele frequency- A:0.50NA 2
    rs98180661,2
    C,F,A,H,--181940157(+) CGGCGG/CGACCT 1 -- us2k111Minor allele frequency- C:0.30EA NS NA WA CSA 686
    rs168593101,2
    C,F,H,--181940790(+) TGAAAG/AGTGGG 1 -- int111Minor allele frequency- A:0.02NA EA NS WA 1020
    rs767740151,2
    --181940915(+) CAGGAG/AGATAG 1 -- int12Minor allele frequency- A:0.08CSA WA 120
    rs1115282601,2
    --181941292(+) ACGTGC/GGTTTG 1 -- int12Minor allele frequency- G:0.33CSA 3
    rs67760411,2
    C,F,H,--181941405(+) GAACTA/GCTGGG 1 -- int18Minor allele frequency- G:0.04NA EA NS WA 536

    HapMap Linkage Disequilibrium report for VPS8 (184529931 - 184770402 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 3 variations for VPS8
         3 CNVs: 68520 68519 98556

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    VPS8 for disorders           About MalaCards

    VPS8 for disorders           About GeneDecksing

    Human Genome Epidemiology (HuGE) Navigator: VPS8 (1 document)

    Export disorders for VPS8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for VPS8 gene, integrated from 9 sources (see all 13):
    (articles sorted by number of sources associating them with VPS8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 9872452)1, 2, 3 Nagase T.... Ohara O. (1998)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. Combined analysis of three genome-wide association st udies on vWF and FVIII plasma levels. (PubMed id 21810271)1 Antoni G....Tregouet D.A. (2011)
    5. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
    6. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    7. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
    8. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
    9. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
    10. The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)2 Muzny D.M....Gibbs R.A. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23355 HGNC: 29122 AceView: KIAA0804 Ensembl:ENSG00000156931 euGenes: HUgn23355
    ECgene: VPS8 H-InvDB: VPS8

    (According to HUGE)
    About This Section
    HUGE: KIAA0804

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for VPS8 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for VPS8 gene:
    Search GeneIP for patents involving VPS8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

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