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Aliases for VPS72 Gene

Aliases for VPS72 Gene

  • Vacuolar Protein Sorting 72 Homolog 2 3 5
  • Transcription Factor-Like 1 2 3 4
  • TCFL1 3 4
  • YL1 3 4
  • Vacuolar Protein Sorting-Associated Protein 72 Homolog 3
  • Vacuolar Protein Sorting 72 Homolog (S. Cerevisiae) 2
  • Vacuolar Protein Sorting 72 (Yeast) 2
  • Transformation Suppressor Gene YL-1 3
  • Protein YL-1 4
  • CFL1 3
  • Swc2 3
  • YL-1 3

External Ids for VPS72 Gene

Previous HGNC Symbols for VPS72 Gene

  • TCFL1

Previous GeneCards Identifiers for VPS72 Gene

  • GC01M147963
  • GC01M149415
  • GC01M122527

Summaries for VPS72 Gene

Entrez Gene Summary for VPS72 Gene

  • The protein encoded by this gene is a shared subunit of two multi-component complexes, the histone acetyltransferase complex TRRAP/TIP60 as well as the chromatin remodeling SRCAP-containing complex. The TRRAP/TIP60 complex acetylates nucleosomal histones important for transcriptional regulation, double strand DNA break repair and apoptosis. The SRCAP-containing complex catalyzes the exchange of histone H2A with the histone variant Htz1 (H2AFZ) into nucleosomes. This protein may be responsible for binding H2AFZ, which has a role in chromosome segregation. This protein may also have a role in regulating long-term hematopoietic stem cell activity. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Aug 2012]

GeneCards Summary for VPS72 Gene

VPS72 (Vacuolar Protein Sorting 72 Homolog) is a Protein Coding gene. Among its related pathways are Chromatin organization.

UniProtKB/Swiss-Prot for VPS72 Gene

  • Could be a DNA-binding transcriptional regulator. May be involved in chromatin modification and remodeling.

Gene Wiki entry for VPS72 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VPS72 Gene

Genomics for VPS72 Gene

Regulatory Elements for VPS72 Gene

Enhancers for VPS72 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F151308 1.8 FANTOM5 Ensembl ENCODE 13 -116.6 -116616 6.1 CREB3L1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC GABPB2 SETDB1 MRPL9 GOLPH3L ZNF687 PRPF3 ADAMTSL4 RFX5 VPS72 UBE2D3P3
GH01F151986 1.8 FANTOM5 Ensembl ENCODE 12.9 -799.2 -799162 16.2 HDGF PKNOX1 ARNT ARID4B SIN3A FEZF1 YBX1 ZNF2 ZNF143 ZNF207 GABPB2 ENSG00000229021 THEM4 LYSMD1 VPS72 RPS10P6 MRPL9 S100A11 SCNM1 THEM5
GH01F150609 1.6 FANTOM5 ENCODE 12.9 +582.5 582535 7.4 PKNOX1 ARID4B SIN3A YY1 SLC30A9 ZNF143 FOS SP3 JUNB MXD4 HORMAD1 MCL1 CTSS ARNT GOLPH3L VPS72 CDC42SE1 LYSMD1 GABPB2 VPS45
GH01F151971 1.6 FANTOM5 Ensembl ENCODE 12.9 -777.6 -777635 2.8 ATF1 PKNOX1 FEZF1 ZNF2 GLIS2 KLF7 FOS DEK ZNF263 SP3 ENSG00000229021 THEM4 S100A10 VPS72 MRPL9 SCNM1 LYSMD1 S100A11 GABPB2 THEM5
GH01F152045 1.5 FANTOM5 ENCODE 12.9 -853.3 -853284 6.6 HDGF PKNOX1 CREB3L1 ARID4B SIN3A YBX1 FEZF1 DMAP1 ZNF2 ZNF143 MRPL9 FLG-AS1 VPS72 RPS10P6 SCNM1 LYSMD1 GABPB2 ENSG00000229021 RN7SL444P S100A11
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around VPS72 on UCSC Golden Path with GeneCards custom track

Promoters for VPS72 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001750105 221 201 GTF2F1 TBP TAF1 SIN3A CEBPG THRB GATA3 POLR2A FOXK2 PRDM10
ENSR00001750106 -879 1601 PKNOX1 ARID4B SIN3A BRCA1 ZNF2 GTF3C2 ZNF121 GLIS2 GATA2 KLF7

Genomic Location for VPS72 Gene

Chromosome:
1
Start:
151,169,987 bp from pter
End:
151,195,321 bp from pter
Size:
25,335 bases
Orientation:
Minus strand

Genomic View for VPS72 Gene

Genes around VPS72 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
VPS72 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for VPS72 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VPS72 Gene

Proteins for VPS72 Gene

  • Protein details for VPS72 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15906-VPS72_HUMAN
    Recommended name:
    Vacuolar protein sorting-associated protein 72 homolog
    Protein Accession:
    Q15906
    Secondary Accessions:
    • A6NLK9
    • A6PW55
    • Q53GJ2
    • Q5U0R4

    Protein attributes for VPS72 Gene

    Size:
    364 amino acids
    Molecular mass:
    40594 Da
    Quaternary structure:
    • Component of the NuA4 histone acetyltransferase complex which contains the catalytic subunit KAT5/TIP60 and the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin, ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41 and VPS72/YL1. Component of a NuA4-related complex which contains EP400, TRRAP/PAF400, SRCAP, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, actin, ACTL6A/BAF53A, VPS72 and YEATS4/GAS41. Also part of a multiprotein complex which contains SRCAP and which binds to H2AFZ/H2AZ.

    Three dimensional structures from OCA and Proteopedia for VPS72 Gene

    Alternative splice isoforms for VPS72 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for VPS72 Gene

Post-translational modifications for VPS72 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for VPS72 Gene

No data available for DME Specific Peptides for VPS72 Gene

Domains & Families for VPS72 Gene

Gene Families for VPS72 Gene

Protein Domains for VPS72 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for VPS72 Gene

Graphical View of Domain Structure for InterPro Entry

Q15906

UniProtKB/Swiss-Prot:

VPS72_HUMAN :
  • Belongs to the VPS72/YL1 family.
Family:
  • Belongs to the VPS72/YL1 family.
genes like me logo Genes that share domains with VPS72: view

Function for VPS72 Gene

Molecular function for VPS72 Gene

UniProtKB/Swiss-Prot Function:
Could be a DNA-binding transcriptional regulator. May be involved in chromatin modification and remodeling.

Gene Ontology (GO) - Molecular Function for VPS72 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 15647280
genes like me logo Genes that share ontologies with VPS72: view
genes like me logo Genes that share phenotypes with VPS72: view

Animal Models for VPS72 Gene

MGI Knock Outs for VPS72:

Animal Model Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for VPS72

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for VPS72 Gene

Localization for VPS72 Gene

Subcellular locations from UniProtKB/Swiss-Prot for VPS72 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for VPS72 gene
Compartment Confidence
nucleus 5
cytoskeleton 2
cytosol 1

Gene Ontology (GO) - Cellular Components for VPS72 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 7702631
GO:0005654 nucleoplasm TAS --
GO:0043234 protein complex IDA 14966270
genes like me logo Genes that share ontologies with VPS72: view

Pathways & Interactions for VPS72 Gene

genes like me logo Genes that share pathways with VPS72: view

Pathways by source for VPS72 Gene

Gene Ontology (GO) - Biological Process for VPS72 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter TAS 7702631
GO:0006338 chromatin remodeling IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0016569 covalent chromatin modification IEA --
genes like me logo Genes that share ontologies with VPS72: view

No data available for SIGNOR curated interactions for VPS72 Gene

Transcripts for VPS72 Gene

Unigene Clusters for VPS72 Gene

Vacuolar protein sorting 72 homolog (S. cerevisiae):
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for VPS72

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for VPS72 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c
SP1: -
SP2:
SP3:

Relevant External Links for VPS72 Gene

GeneLoc Exon Structure for
VPS72
ECgene alternative splicing isoforms for
VPS72

Expression for VPS72 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for VPS72 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for VPS72 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (18.5), Blymphocyte (8.4), CD8 Tcells (6.9), and Fetal Brain (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for VPS72 Gene



Protein tissue co-expression partners for VPS72 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of VPS72 Gene:

VPS72

SOURCE GeneReport for Unigene cluster for VPS72 Gene:

Hs.2430
genes like me logo Genes that share expression patterns with VPS72: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for VPS72 Gene

Orthologs for VPS72 Gene

This gene was present in the common ancestor of animals.

Orthologs for VPS72 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia VPS72 34 35
  • 99.45 (n)
oppossum
(Monodelphis domestica)
Mammalia VPS72 35
  • 92 (a)
OneToOne
cow
(Bos Taurus)
Mammalia VPS72 34 35
  • 91.58 (n)
dog
(Canis familiaris)
Mammalia VPS72 34 35
  • 90.84 (n)
rat
(Rattus norvegicus)
Mammalia Vps72 34
  • 87.09 (n)
mouse
(Mus musculus)
Mammalia Vps72 34 16 35
  • 86.9 (n)
chicken
(Gallus gallus)
Aves VPS72 35
  • 72 (a)
OneToOne
LOC100859689 34
  • 67.96 (n)
lizard
(Anolis carolinensis)
Reptilia VPS72 35
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia vps72 34
  • 63.74 (n)
Str.9975 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.11940 34
zebrafish
(Danio rerio)
Actinopterygii vps72 34 35
  • 63.14 (n)
VPS72 (2 of 2) 35
  • 57 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.871 34
fruit fly
(Drosophila melanogaster)
Insecta YL-1 34 35
  • 50.66 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001565 34
  • 46.75 (n)
worm
(Caenorhabditis elegans)
Secernentea C17E4.6 35
  • 28 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10900 35
  • 42 (a)
OneToOne
Species where no ortholog for VPS72 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for VPS72 Gene

ENSEMBL:
Gene Tree for VPS72 (if available)
TreeFam:
Gene Tree for VPS72 (if available)

Paralogs for VPS72 Gene

No data available for Paralogs for VPS72 Gene

Variants for VPS72 Gene

Sequence variations from dbSNP and Humsavar for VPS72 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
VAR_035803 A breast cancer sample
rs111263505 -- 151,179,316(+) AGGGC(C/T)GGGCT intron-variant
rs111342247 -- 151,181,469(+) CGAAC(G/T)CCTTA intron-variant
rs111448120 -- 151,186,565(+) AAAAG(-/A)AAAAA intron-variant
rs111640172 -- 151,186,920(+) AATCC(A/C)CTCCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for VPS72 Gene

Variant ID Type Subtype PubMed ID
nsv522840 CNV gain 19592680
dgv2n68 CNV loss 17160897

Variation tolerance for VPS72 Gene

Residual Variation Intolerance Score: 25% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.01; 20.77% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for VPS72 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
VPS72

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VPS72 Gene

Disorders for VPS72 Gene

Relevant External Links for VPS72

Genetic Association Database (GAD)
VPS72
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
VPS72

No disorders were found for VPS72 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for VPS72 Gene

Publications for VPS72 Gene

  1. Molecular cloning of a novel human cDNA on chromosome 1q21 and its mouse homolog encoding a nuclear protein with DNA-binding ability. (PMID: 7702631) Horikawa I. … Oshimura M. (Biochem. Biophys. Res. Commun. 1995) 2 3 4 64
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
  3. The mammalian YL1 protein is a shared subunit of the TRRAP/TIP60 histone acetyltransferase and SRCAP complexes. (PMID: 15647280) Cai Y. … Conaway J.W. (J. Biol. Chem. 2005) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Structural and functional conservation of the NuA4 histone acetyltransferase complex from yeast to humans. (PMID: 14966270) Doyon Y. … Cote J. (Mol. Cell. Biol. 2004) 3 4 64

Products for VPS72 Gene

Sources for VPS72 Gene

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