Aliases for VPS72 Gene
External Ids for VPS72 Gene
Previous HGNC Symbols for VPS72 Gene
Previous GeneCards Identifiers for VPS72 Gene
The protein encoded by this gene is a shared subunit of two multi-component complexes, the histone acetyltransferase complex TRRAP/TIP60 as well as the chromatin remodeling SRCAP-containing complex. The TRRAP/TIP60 complex acetylates nucleosomal histones important for transcriptional regulation, double strand DNA break repair and apoptosis. The SRCAP-containing complex catalyzes the exchange of histone H2A with the histone variant Htz1 (H2AFZ) into nucleosomes. This protein may be responsible for binding H2AFZ, which has a role in chromosome segregation. This protein may also have a role in regulating long-term hematopoietic stem cell activity. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Aug 2012]
GeneCards Summary for VPS72 Gene
UniProtKB/Swiss-Prot for VPS72 Gene
Could be a DNA-binding transcriptional regulator. May be involved in chromatin modification and remodeling.