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Aliases for VPS72 Gene

Aliases for VPS72 Gene

  • Vacuolar Protein Sorting 72 Homolog (S. Cerevisiae) 2 3
  • Transcription Factor-Like 1 2 3 4
  • YL1 3 4 6
  • TCFL1 3 4
  • CFL1 3 6
  • Vacuolar Protein Sorting-Associated Protein 72 Homolog 3
  • Vacuolar Protein Sorting 72 (Yeast) 2
  • Transformation Suppressor Gene YL-1 3
  • Protein YL-1 4
  • Swc2 3
  • YL-1 3

External Ids for VPS72 Gene

Previous Symbols for VPS72 Gene

  • TCFL1

Summaries for VPS72 Gene

Entrez Gene Summary for VPS72 Gene

  • The protein encoded by this gene is a shared subunit of two multi-component complexes, the histone acetyltransferase complex TRRAP/TIP60 as well as the chromatin remodeling SRCAP-containing complex. The TRRAP/TIP60 complex acetylates nucleosomal histones important for transcriptional regulation, double strand DNA break repair and apoptosis. The SRCAP-containing complex catalyzes the exchange of histone H2A with the histone variant Htz1 (H2AFZ) into nucleosomes. This protein may be responsible for binding H2AFZ, which has a role in chromosome segregation. This protein may also have a role in regulating long-term hematopoietic stem cell activity. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Aug 2012]

GeneCards Summary for VPS72 Gene

VPS72 (Vacuolar Protein Sorting 72 Homolog (S. Cerevisiae)) is a Protein Coding gene. Among its related pathways are Regulation of actin cytoskeleton and Regulation of actin cytoskeleton.

UniProtKB/Swiss-Prot for VPS72 Gene

  • Could be a DNA-binding transcriptional regulator. May be involved in chromatin modification and remodeling

Gene Wiki entry for VPS72 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VPS72 Gene

Genomics for VPS72 Gene

Genomic Location for VPS72 Gene

Start:
151,169,987 bp from pter
End:
151,195,321 bp from pter
Size:
25,335 bases
Orientation:
Minus strand

Genomic View for VPS72 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for VPS72 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VPS72 Gene

Regulatory Elements for VPS72 Gene

Proteins for VPS72 Gene

  • Protein details for VPS72 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15906-VPS72_HUMAN
    Recommended name:
    Vacuolar protein sorting-associated protein 72 homolog
    Protein Accession:
    Q15906
    Secondary Accessions:
    • A6NLK9
    • A6PW55
    • Q53GJ2
    • Q5U0R4

    Protein attributes for VPS72 Gene

    Size:
    364 amino acids
    Molecular mass:
    40594 Da
    Quaternary structure:
    • Component of the NuA4 histone acetyltransferase complex which contains the catalytic subunit KAT5/TIP60 and the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin, ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41 and VPS72/YL1. Component of a NuA4-related complex which contains EP400, TRRAP/PAF400, SRCAP, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, actin, ACTL6A/BAF53A, VPS72 and YEATS4/GAS41. Also part of a multiprotein complex which contains SRCAP and which binds to H2AFZ/H2AZ.

    Alternative splice isoforms for VPS72 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for VPS72 Gene

Proteomics data for VPS72 Gene at MOPED

Post-translational modifications for VPS72 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for VPS72 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for VPS72 Gene

Domains for VPS72 Gene

Protein Domains for VPS72 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

VPS72_HUMAN
Family:
  • Belongs to the VPS72/YL1 family.:
    • Q15906
genes like me logo Genes that share domains with VPS72: view

No data available for Gene Families for VPS72 Gene

Function for VPS72 Gene

Molecular function for VPS72 Gene

UniProtKB/Swiss-Prot Function: Could be a DNA-binding transcriptional regulator. May be involved in chromatin modification and remodeling

Gene Ontology (GO) - Molecular Function for VPS72 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 15647280
genes like me logo Genes that share ontologies with VPS72: view

Phenotypes for VPS72 Gene

MGI mutant phenotypes for VPS72:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with VPS72: view

miRNA for VPS72 Gene

miRTarBase miRNAs that target VPS72

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for VPS72 Gene

Localization for VPS72 Gene

Subcellular locations from UniProtKB/Swiss-Prot for VPS72 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for VPS72 Gene COMPARTMENTS Subcellular localization image for VPS72 gene
Compartment Confidence
nucleus 5
cytoskeleton 2
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for VPS72 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 7702631
GO:0005654 nucleoplasm TAS --
GO:0043234 protein complex IDA 14966270
genes like me logo Genes that share ontologies with VPS72: view

Pathways for VPS72 Gene

genes like me logo Genes that share pathways with VPS72: view

Gene Ontology (GO) - Biological Process for VPS72 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter TAS 7702631
GO:0006325 chromatin organization TAS --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated --
GO:0016568 chromatin modification IEA --
genes like me logo Genes that share ontologies with VPS72: view

Transcripts for VPS72 Gene

Unigene Clusters for VPS72 Gene

Vacuolar protein sorting 72 homolog (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for VPS72 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c
SP1: -
SP2:
SP3:

Relevant External Links for VPS72 Gene

GeneLoc Exon Structure for
VPS72
ECgene alternative splicing isoforms for
VPS72

Expression for VPS72 Gene

mRNA expression in normal human tissues for VPS72 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for VPS72 Gene

SOURCE GeneReport for Unigene cluster for VPS72 Gene Hs.2430

genes like me logo Genes that share expressions with VPS72: view

Orthologs for VPS72 Gene

This gene was present in the common ancestor of animals.

Orthologs for VPS72 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia VPS72 36
  • 99.45 (n)
  • 99.73 (a)
VPS72 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia VPS72 36
  • 91.58 (n)
  • 96.43 (a)
VPS72 37
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia VPS72 36
  • 90.84 (n)
  • 98.08 (a)
VPS72 37
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Vps72 36
  • 86.9 (n)
  • 96.98 (a)
Vps72 16
Vps72 37
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia VPS72 37
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Vps72 36
  • 87.09 (n)
  • 96.7 (a)
chicken
(Gallus gallus)
Aves LOC100859689 36
  • 67.96 (n)
  • 72.3 (a)
VPS72 37
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia VPS72 37
  • 61 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.11940 36
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.9975 36
vps72 36
  • 63.74 (n)
  • 65.44 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.871 36
zebrafish
(Danio rerio)
Actinopterygii vps72 36
  • 63.14 (n)
  • 65.26 (a)
vps72 37
  • 59 (a)
OneToMany
VPS72 (2 of 2) 37
  • 57 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001565 36
  • 46.75 (n)
  • 42.72 (a)
fruit fly
(Drosophila melanogaster)
Insecta YL-1 36
  • 50.66 (n)
  • 47.02 (a)
YL-1 37
  • 37 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea C17E4.6 37
  • 28 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10900 37
  • 42 (a)
OneToOne
Species with no ortholog for VPS72:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for VPS72 Gene

ENSEMBL:
Gene Tree for VPS72 (if available)
TreeFam:
Gene Tree for VPS72 (if available)

Paralogs for VPS72 Gene

No data available for Paralogs for VPS72 Gene

Variants for VPS72 Gene

Sequence variations from dbSNP and Humsavar for VPS72 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs4970943 -- 151,183,905(+) ttttt(A/T)aagag intron-variant
rs4970944 -- 151,190,841(+) CCCAC(A/G)TTTTG upstream-variant-2KB
rs4971011 -- 151,185,289(+) CCTGG(C/T)TAATT intron-variant
rs4971012 -- 151,191,364(+) agcag(G/T)gggaa upstream-variant-2KB
rs11204785 -- 151,178,381(+) CCCTC(C/T)ATAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for VPS72 Gene

Variant ID Type Subtype PubMed ID
nsv522840 CNV Gain 19592680
dgv2n68 CNV Loss 17160897

Relevant External Links for VPS72 Gene

HapMap Linkage Disequilibrium report
VPS72

Disorders for VPS72 Gene

Relevant External Links for VPS72

Genetic Association Database (GAD)
VPS72
genes like me logo Genes that share disorders with VPS72: view

No data available for UniProtKB/Swiss-Prot for VPS72 Gene

Publications for VPS72 Gene

  1. Molecular cloning of a novel human cDNA on chromosome 1q21 and its mouse homolog encoding a nuclear protein with DNA-binding ability. (PMID: 7702631) Horikawa I. … Oshimura M. (Biochem. Biophys. Res. Commun. 1995) 2 3 4
  2. Structural and functional conservation of the NuA4 histone acetyltransferase complex from yeast to humans. (PMID: 14966270) Doyon Y. … Cote J. (Mol. Cell. Biol. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. The mammalian YL1 protein is a shared subunit of the TRRAP/TIP60 histone acetyltransferase and SRCAP complexes. (PMID: 15647280) Cai Y. … Conaway J.W. (J. Biol. Chem. 2005) 3 4
  5. Forced expression of YL-1 protein suppresses the anchorage-independent growth of Kirsten sarcoma virus-transformed NIH3T3 cells. (PMID: 7664828) Horikawa I. … Oshimura M. (Exp. Cell Res. 1995) 3 23

Products for VPS72 Gene

  • Addgene plasmids for VPS72

Sources for VPS72 Gene

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