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VPS72 Gene

protein-coding   GIFtS: 56
GCID: GC01M151143

Vacuolar Protein Sorting 72 Homolog (S. Cerevisiae)

(Previous names: transcription factor-like 1, vacuolar protein sorting 72...)
(Previous symbol: TCFL1)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Vacuolar Protein Sorting 72 Homolog (S. Cerevisiae)1 2     Swc22
Transcription Factor-Like 11 2 3     YL-12
TCFL11 2 3     Transformation Suppressor Gene YL-12
YL12 3 5     Vacuolar Protein Sorting-Associated Protein 72 Homolog2
CFL12 5     Protein YL-13
Vacuolar Protein Sorting 72 (Yeast)1     

External Ids:    HGNC: 116441   Entrez Gene: 69442   Ensembl: ENSG000001631597   OMIM: 6006075   UniProtKB: Q159063   

Export aliases for VPS72 gene to outside databases

Previous GC identifers: GC01M147963 GC01M149415 GC01M122527


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for VPS72 Gene:
The protein encoded by this gene is a shared subunit of two multi-component complexes, the histone
acetyltransferase complex TRRAP/TIP60 as well as the chromatin remodeling SRCAP-containing complex. The
TRRAP/TIP60 complex acetylates nucleosomal histones important for transcriptional regulation, double strand DNA
break repair and apoptosis. The SRCAP-containing complex catalyzes the exchange of histone H2A with the histone
variant Htz1 (H2AFZ) into nucleosomes. This protein may be responsible for binding H2AFZ, which has a role in
chromosome segregation. This protein may also have a role in regulating long-term hematopoietic stem cell
activity. Alternative splicing results in multiple transcript variants that encode different protein isoforms.
(provided by RefSeq, Aug 2012)

GeneCards Summary for VPS72 Gene:
VPS72 (vacuolar protein sorting 72 homolog (S. cerevisiae)) is a protein-coding gene.

UniProtKB/Swiss-Prot: VPS72_HUMAN, Q15906
Function: Could be a DNA-binding transcriptional regulator. May be involved in chromatin modification and
remodeling

Gene Wiki entry for VPS72 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_004487.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the VPS72 gene promoter:
         MAZR   Sp1   FOXO3   FOXO3b   C/EBPalpha   HOXA5   FOXO3a   SEF-1 (1)   Pax-4a   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidVPS72 promoter sequence
   Search Chromatin IP Primers for VPS72

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat VPS72


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21   Ensembl cytogenetic band:  1q21.3   HGNC cytogenetic band: 1q21

VPS72 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
VPS72 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M151143:  view genomic region     (about GC identifiers)

Start:
151,142,463 bp from pter      End:
151,167,797 bp from pter
Size:
25,335 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: VPS72_HUMAN, Q15906 (See protein sequence)
Recommended Name: Vacuolar protein sorting-associated protein 72 homolog  
Size: 364 amino acids; 40594 Da
Subunit: Component of the NuA4 histone acetyltransferase complex which contains the catalytic subunit KAT5/TIP60
and the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin,
ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41 and VPS72/YL1. Component of a NuA4-related
complex which contains EP400, TRRAP/PAF400, SRCAP, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, actin,
ACTL6A/BAF53A, VPS72 and YEATS4/GAS41. Also part of a multiprotein complex which contains SRCAP and which binds
to H2AFZ/H2AZ
Secondary accessions: A6NLK9 A6PW55 Q53GJ2 Q5U0R4
Alternative splicing: 2 isoforms:  Q15906-1   Q15906-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for VPS72: NX_Q15906

Explore proteomics data for VPS72 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See VPS72 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001258016.1  NP_001258017.1  NP_005988.1  

    ENSEMBL proteins: 
     ENSP00000357887   ENSP00000346464  
    Reactome Protein details: Q15906

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR013272 YL1_C
     IPR008895 YL1

    Graphical View of Domain Structure for InterPro Entry Q15906

    ProtoNet protein and cluster: Q15906

    UniProtKB/Swiss-Prot: VPS72_HUMAN, Q15906
    Similarity: Belongs to the VPS72/YL1 family


    Find genes that share domains with VPS72           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: VPS72_HUMAN, Q15906
    Function: Could be a DNA-binding transcriptional regulator. May be involved in chromatin modification and
    remodeling

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0005515protein binding IPI15647280
         
    Find genes that share ontologies with VPS72           About GenesLikeMe


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Vps72):
     mortality/aging 

    Find genes that share phenotypes with VPS72           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for VPS72

    miRNA
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    miRTarBase miRNAs that target VPS72:
    hsa-mir-615-3p (MIRT039650)

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    VPS72_HUMAN, Q15906: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytoskeleton2
    cytosol1
    lysosome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus TAS7702631
    GO:0005654nucleoplasm TAS--
    GO:0043234protein complex IDA14966270

    Find genes that share ontologies with VPS72           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for VPS72 About    
    See pathways by source

    SuperPathContained pathways About
    1RNA Polymerase I Promoter Opening
    HATs acetylate histones0.34
    Chromatin organization0.34
    Chromatin modifying enzymes0.34


    Find genes that share SuperPaths with VPS72           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for VPS72 (see all 15)
        RhoA Pathway
    Sertoli-Sertoli Cell Junction Dynamics
    Actin-Based Motility by Rho Family GTPases
    Guidance Cues and Growth Cone Motility
    Internalin Pathway

    1 Reactome Pathway for VPS72
        HATs acetylate histones


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for VPS72
    Interactions:

        Search GeneGlobe Interaction Network for VPS72

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for VPS72 (Q159061, 2, 3 ENSP000003578874) via UniProtKB, MINT, STRING, and/or I2D (see all 279)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CCDC85BQ158342, 3, ENSP000003116954MINT-67421 I2D: score=5 STRING: ENSP00000311695
    RUVBL1Q9Y2651, 3, ENSP000003182974EBI-399189,EBI-353675 I2D: score=2 STRING: ENSP00000318297
    CALCOCO2Q131372, 3, ENSP000002589474MINT-66929 I2D: score=5 STRING: ENSP00000258947
    MDFIQ997502, 3, ENSP000002303214MINT-68298 I2D: score=5 STRING: ENSP00000230321
    DMAP1Q9NPF53, ENSP000003126974I2D: score=5 STRING: ENSP00000312697
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter TAS7702631
    GO:0006325chromatin organization TAS--
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0016568chromatin modification IEA--

    Find genes that share ontologies with VPS72           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for VPS72



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for VPS72 gene (3 alternative transcripts): 
    NM_001271087.1  NM_001271088.1  NM_005997.2  

    Unigene Cluster for VPS72:

    Vacuolar protein sorting 72 homolog (S. cerevisiae)
    Hs.2430  [show with all ESTs]
    Unigene Representative Sequence: AK225130
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000491094(uc001exc.4 uc010pct.2) ENST00000368892(uc001exe.1 uc001exf.1)
    ENST00000354473 ENST00000496809 ENST00000471423 ENST00000463470
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    Addgene plasmids for VPS72 
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat VPS72
      QuantiTect SYBR Green Assays in human, mouse, rat VPS72
      QuantiFast Probe-based Assays in human, mouse, rat VPS72

    Additional mRNA sequence: 

    AK222935.1 AK222939.1 AK225130.1 AK297565.1 AK310045.1 BC003151.1 BT019356.1 BT019357.1 
    D43642.1 DQ655941.2 DQ656047.2 

    15 DOTS entries:

    DT.92020583  DT.451751  DT.95318252  DT.100685011  DT.92062222  DT.95318262  DT.100865702  DT.121409559 
    DT.121409634  DT.99938514  DT.100060066  DT.100685026  DT.100691338  DT.91832465  DT.40297177 

    Selected AceView cDNA sequences (see all 350):

    BQ774512 BM727067 BQ279112 CR598351 CR599603 BM792617 BU732195 F24907 
    BG824097 CR623974 BQ774265 BM976207 CD106488 BU538644 BU501942 BC003151 
    BU628890 CB141104 AX747678 W84830 D43642 AA197009 F30690 BU539222 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for VPS72    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c
    SP1:                                                  -               
    SP2:                                                                  
    SP3:                                                                  


    ECgene alternative splicing isoforms for VPS72

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    VPS72 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GACTGCCGCC
    VPS72 Expression
    About this image


    VPS72 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Limb (Muscoskeletal System)
             Limb Bud Mesenchyme Cells Limb Bud
     
     Mesoderm (Gastrulation Derivatives)
             Limb Bud Mesenchyme Cells Limb Bud
    VPS72 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    VPS72 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.2430
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for VPS72 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Vps721 , 5 vacuolar protein sorting 72 (yeast)1, 5 86.9(n)1
    96.98(a)1
      3 (40.74 cM)5
    214271  NM_009336.21  NP_033362.21 
     951110225 
    chicken
    (Gallus gallus)
    Aves LOC1008596891 vacuolar protein sorting-associated protein 72 homolog 67.96(n)
    72.3(a)
      100859689  XM_004948328.1  XP_004948385.1 
    lizard
    (Anolis carolinensis)
    Reptilia VPS726
    vacuolar protein sorting 72 homolog (S. cerevisiae...
    61(a)
    1 ↔ 1
    GL343668.1(105214-123480)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.119402 Xenopus laevis transcribed sequence with weak similarity more 73.77(n)    BU907783.1 
    zebrafish
    (Danio rerio)
    Actinopterygii vps721 vacuolar protein sorting 72 homolog (S. cerevisiae) 63.14(n)
    65.26(a)
      100001285  NM_001082944.1  NP_001076413.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta YL-11 YL-1 50.66(n)
    47.02(a)
      34516  NM_135631.3  NP_609475.1 
    worm
    (Caenorhabditis elegans)
    Secernentea C17E4.66
    Protein C17E4.6 (C17E4.6) mRNA, complete cds
    28(a)
    1 ↔ 1
    I(9422556-9431112) WBGene00007645


    ENSEMBL Gene Tree for VPS72 (if available)
    TreeFam Gene Tree for VPS72 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for VPS72 (see all 267)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0358034
    A breast cancer sample4--see VAR_0358032 I V mis40--------
    rs1440826121,2
    C--151150560(+) GGCCCG/AGGGCA 5 /P syn1 int11Minor allele frequency- A:0.00NA 4550
    rs112047851,2
    C,F,H--151150857(+) CCCTCC/TATAGT 3 -- int127Minor allele frequency- T:0.42NS EA NA WA CSA 2545
    rs1117613271,2
    C--151151064(+) GGCACCA/-CATTG 3 -- int11Minor allele frequency- -:0.50CSA 2
    rs1891978651,2
    --151151117(+) AAAAAA/CTTAGT 3 -- int10--------
    rs1913765751,2
    --151151163(+) GGTCGC/TTCTTA 3 -- int10--------
    rs2019345281,2
    --151151168(+) CTCTT-/AAAC  
            
    AACAA
    3 -- int10--------
    rs1166071601,2
    F--151151181(+) AGAAAA/GTCTCG 3 -- int11Minor allele frequency- G:0.01WA 118
    rs1835655411,2
    --151151285(+) CTCTGA/GCTGGC 3 -- int10--------
    rs760234701,2
    C--151151339(+) ATGGCG/AATGCA 3 -- int11Minor allele frequency- A:0.01NA 120

    HapMap Linkage Disequilibrium report for VPS72 (151142463 - 151167797 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for VPS72:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv2n68CNV Loss17160897
    nsv522840CNV Gain19592680

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600607    OMIM disorders: --


    Find genes that share disorders with VPS72           About GenesLikeMe

    Genetic Association Database (GAD): VPS72

    Export disorders for VPS72 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for VPS72 gene, integrated from 10 sources (see all 24):
    (articles sorted by number of sources associating them with VPS72)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of a novel human cDNA on chromosome 1q21 and its mouse homolog encoding a nuclear protein with DNA-binding ability. (PubMed id 7702631)1, 2, 3 Horikawa I.... Oshimura M. (Biochem. Biophys. Res. Commun. 1995)
    2. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    3. The mammalian YL1 protein is a shared subunit of the TRRAP/TIP60 histone acetyltransferase and SRCAP complexes. (PubMed id 15647280)1, 2 Cai Y.... Conaway J.W. (J. Biol. Chem. 2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Structural and functional conservation of the NuA4 histone acetyltransferase complex from yeast to humans. (PubMed id 14966270)1, 2 Doyon Y.... Cote J. (Mol. Cell. Biol. 2004)
    6. Forced expression of YL-1 protein suppresses the anchorage-independent growth of Kirsten sarcoma virus-transformed NIH3T3 cells. (PubMed id 7664828)1, 9 Horikawa I....Oshimura M. (Exp. Cell Res. 1995)
    7. A Y2H-seq approach defines the human protein methyltransferase interactome. (PubMed id 23455924)1 Weimann M.... Stelzl U. (Nat. Methods 2013)
    8. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    9. Integrin-I+vI^3 regulates thrombopoietin-mediated maintenance of hematopoietic stem cells. (PubMed id 22096247)1 Umemoto T....Okano T. (Blood 2012)
    10. H2A.Z.2.2 is an alternatively spliced histone H2A.Z variant that causes severe nucleosome destabilization. (PubMed id 22467210)1 BAPnisch C....Hake S.B. (Nucleic Acids Res. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6944 HGNC: 11644 AceView: TCFL1andTMOD4 Ensembl:ENSG00000163159 euGenes: HUgn6944
    ECgene: VPS72 H-InvDB: VPS72

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for VPS72 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for VPS72 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for VPS72 gene:
    Search GeneIP for patents involving VPS72

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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