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VPS54 Gene

protein-coding   GIFtS: 52
GCID: GC02M064119

Vacuolar Protein Sorting 54 Homolog (S. Cerevisiae)

(Previous name: vacuolar protein sorting 54 (yeast))
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Vacuolar Protein Sorting 54 Homolog (S. Cerevisiae)1 2     WR2 5
Hepatocellular Carcinoma Protein 82 3     Vacuolar Protein Sorting 54 (Yeast)1
Tumor Antigen HOM-HCC-82 3     SLP-8p2
Tumor Antigen SLP-8p2 3     hVps54L2
HCC82 3     Vacuolar Protein Sorting-Associated Protein 542
VPS54L2 5     

External Ids:    HGNC: 186521   Entrez Gene: 515422   Ensembl: ENSG000001439527   OMIM: 6146335   UniProtKB: Q9P1Q03   

Export aliases for VPS54 gene to outside databases

Previous GC identifers: GC02M064076 GC02M064093 GC02M064094 GC02M064031 GC02M063973 GC02M063859


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for VPS54 Gene:
This gene encodes for a protein that in yeast forms part of a trimeric vacuolar-protein-sorting complex that is
required for retrograde transport of proteins from prevacuoles to the late Golgi compartment. As in yeast,
mammalian Vps54 proteins contain a coiled-coil region and dileucine motifs. Alternative splicing results in
multiple transcript variants encoding different isoforms (provided by RefSeq, Jul 2008)

GeneCards Summary for VPS54 Gene:
VPS54 (vacuolar protein sorting 54 homolog (S. cerevisiae)) is a protein-coding gene. Diseases associated with VPS54 include hepatocellular carcinoma, and lateral sclerosis.

UniProtKB/Swiss-Prot: VPS54_HUMAN, Q9P1Q0
Function: May be involved in retrograde transport from early and late endosomes to the late Golgi. The GARP
complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and
endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000002.12  NT_022184.16  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the VPS54 gene promoter:
         USF1   USF2   USF-1:USF-2   MEF-2A   USF-1   FOXO1a   aMEF-2   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidVPS54 promoter sequence
   Search Chromatin IP Primers for VPS54

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat VPS54


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p13-p14   Ensembl cytogenetic band:  2p14   HGNC cytogenetic band: 2p15-p14

VPS54 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
VPS54 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M064119:  view genomic region     (about GC identifiers)

Start:
64,119,280 bp from pter      End:
64,246,214 bp from pter
Size:
126,935 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: VPS54_HUMAN, Q9P1Q0 (See protein sequence)
Recommended Name: Vacuolar protein sorting-associated protein 54  
Size: 977 amino acids; 110589 Da
Subunit: Component of the Golgi-associated retrograde protein (GARP) complex, also called VFT (VPS fifty-three)
complex, composed of VPS51, VPS52, VPS53 and VPS54
Sequence caution: Sequence=BAA92134.1; Type=Erroneous initiation;
Secondary accessions: Q5VIR5 Q86YF7 Q8N6G3 Q9NPV0 Q9NT07 Q9NUJ0
Alternative splicing: 5 isoforms:  Q9P1Q0-1   Q9P1Q0-2   Q9P1Q0-3   Q9P1Q0-4   Q9P1Q0-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for VPS54: NX_Q9P1Q0

Explore proteomics data for VPS54 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See VPS54 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001005739.1  NP_057600.2  

    ENSEMBL proteins: 
     ENSP00000386980   ENSP00000346499   ENSP00000272322   ENSP00000414725  

    VPS54 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR019515 Vacuolar_sorting-assoc_54
     IPR012501 Vps54

    Graphical View of Domain Structure for InterPro Entry Q9P1Q0

    ProtoNet protein and cluster: Q9P1Q0

    1 Blocks protein domain: IPB012501 Vps54-like

    UniProtKB/Swiss-Prot: VPS54_HUMAN, Q9P1Q0
    Similarity: Belongs to the VPS54 family


    VPS54 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: VPS54_HUMAN, Q9P1Q0
    Function: May be involved in retrograde transport from early and late endosomes to the late Golgi. The GARP
    complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and
    endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
         
    VPS54 for ontologies           About GeneDecksing


    Phenotypes:
         15 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Vps54):
     behavior/neurological  cardiovascular system  cellular  craniofacial  embryogenesis 
     endocrine/exocrine gland  growth/size/body  hematopoietic system  homeostasis/metabolism  immune system 
     liver/biliary system  mortality/aging  muscle  nervous system  reproductive system 

    VPS54 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for VPS54
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for VPS54
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for VPS54

    miRNA
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    miRTarBase miRNAs that target VPS54:
    hsa-mir-26b-5p (MIRT028839), hsa-mir-98-5p (MIRT027414), hsa-mir-877-3p (MIRT037142), hsa-mir-21-5p (MIRT030672)

    Block miRNA regulation of human, mouse, rat VPS54 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate VPS54 (see all 27):
    hsa-miR-142-5p hsa-miR-3607-3p hsa-miR-3152-3p hsa-miR-376b hsa-miR-25 hsa-miR-181c* hsa-miR-340 hsa-miR-520a-5p
    SwitchGear 3'UTR luciferase reporter plasmidVPS54 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat VPS54

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    GenScript: all cDNA clones in your preferred vector (see all 2): VPS54 (NM_001005739)
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VPS54


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    VPS54_HUMAN, Q9P1Q0: Golgi apparatus, trans-Golgi network
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    golgi apparatus5
    cytosol2
    endosome2
    nucleus2
    extracellular1
    plasma membrane1
    vacuole1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000938GARP complex IDA19620288

    VPS54 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for VPS54
    Interactions:

        GeneGlobe Interaction Network for VPS54

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for VPS54 (Q9P1Q03 ENSP000002723224) via UniProtKB, MINT, STRING, and/or I2D (see all 77)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    COPS4Q9BT783I2D: score=5 
    VPS53ENSP000004014354STRING: ENSP00000401435
    STX16ENSP000003601834STRING: ENSP00000360183
    EXOC5ENSP000003899344STRING: ENSP00000389934
    ATP6V1AENSP000002733984STRING: ENSP00000273398
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0015031protein transport IEA--
    GO:0040007growth IEA--
    GO:0042147retrograde transport, endosome to Golgi IEA--
    GO:0048873homeostasis of number of cells within a tissue IEA--
    GO:0050881musculoskeletal movement IEA--

    VPS54 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for VPS54



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for VPS54 gene (2 alternative transcripts): 
    NM_001005739.1  NM_016516.2  

    Unigene Cluster for VPS54:

    Vacuolar protein sorting 54 homolog (S. cerevisiae)
    Hs.48499  [show with all ESTs]
    Unigene Representative Sequence: AK124436
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000409558(uc002scp.3) ENST00000354504(uc002scn.3 uc002sco.3 uc010fct.3)
    ENST00000272322(uc002scq.3) ENST00000416400

    miRNA
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    Block miRNA regulation of human, mouse, rat VPS54 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate VPS54 (see all 27):
    hsa-miR-142-5p hsa-miR-3607-3p hsa-miR-3152-3p hsa-miR-376b hsa-miR-25 hsa-miR-181c* hsa-miR-340 hsa-miR-520a-5p
    SwitchGear 3'UTR luciferase reporter plasmidVPS54 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat VPS54
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    GenScript: all cDNA clones in your preferred vector (see all 2): VPS54 (NM_001005739)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for VPS54
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VPS54
    Primer
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    OriGene qPCR primer pairs and template standards for VPS54
    OriGene qSTAR qPCR primer pairs in human, mouse for VPS54
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat VPS54
      QuantiTect SYBR Green Assays in human, mouse, rat VPS54
      QuantiFast Probe-based Assays in human, mouse, rat VPS54

    Additional mRNA sequence: 

    AF102177.1 AK002205.1 AK025545.1 AK094019.1 AK124436.1 AK126141.1 AK292669.1 AK292889.1 
    AL137604.1 AL359939.1 AY444798.1 BC030275.1 BC041868.1 CR749701.1 

    10 DOTS entries:

    DT.100025644  DT.100648268  DT.443152  DT.99950695  DT.95269718  DT.100776628  DT.121020675  DT.431793 
    DT.121020693  DT.91995140 

    Selected AceView cDNA sequences (see all 136):

    AK124436 AL359939 BM724998 BU618428 BE671145 AL137604 AW663966 AK002205 
    AA314675 AI400048 CK822939 AA427813 BU689982 BX279581 AA810742 BP351131 
    AL514510 BQ424740 CN483117 AI363052 CK724970 BG024675 BQ102353 AK025545 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for VPS54    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23a · 23b
    SP1:                                                                                            -                 -                                             
    SP2:                                                                                            -                                                               
    SP3:                                                                                                                                                            


    ECgene alternative splicing isoforms for VPS54

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    VPS54 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGATGTGTTT
    VPS54 Expression
    About this image

    VPS54 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    VPS54 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.48499
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for VPS54 gene from Selected species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Vps541 , 5 vacuolar protein sorting 54 (yeast)1, 5 91.3(n)1
    92.63(a)1
      11 (13.89 cM)5
    2459441  NM_139061.41  NP_620692.31 
     212392815 
    chicken
    (Gallus gallus)
    Aves VPS541 vacuolar protein sorting 54 homolog (S. cerevisiae) 82.34(n)
    86.96(a)
      421280  XM_419349.4  XP_419349.3 
    lizard
    (Anolis carolinensis)
    Reptilia VPS546
    vacuolar protein sorting 54 homolog (S. cerevisiae...
    86(a)
    1 ↔ 1
    1(120462472-120516154)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.196812 Transcribed sequence with moderate similarity to protein more 80.69(n)    BX706987.1 
    zebrafish
    (Danio rerio)
    Actinopterygii vps541 vacuolar protein sorting 54 homolog (S. cerevisiae) 63.92(n)
    68.9(a)
      562169  NM_001130776.1  NP_001124248.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta scat1 scattered 49.5(n)
    41.35(a)
      47942  NM_080166.4  NP_524905.1 
    worm
    (Caenorhabditis elegans)
    Secernentea vps-541 vps-54 46.31(n)
    29.29(a)
      179473  NM_001269297.1  NP_001256226.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons VPS541 VPS54 45.97(n)
    34.8(a)
      827690  NM_179078.2  NP_849409.2 
    rice
    (Oryza sativa)
    Liliopsida Os04g02121001 Os04g0212100 42.98(n)
    30.12(a)
      9267478  NM_001186867.1  NP_001173796.1 


    ENSEMBL Gene Tree for VPS54 (if available)
    TreeFam Gene Tree for VPS54 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for VPS54 (see all 2703)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1929994261,2
    C--64119229(+) AGGCTC/GCTTGT 2 -- ds50010--------
    rs1448310421,2
    --64119256(+) ACCACC/TTAAAA 2 -- ds50010--------
    rs2000078151,2
    --64119472(+) TGTGA-/GGGTGA 2 -- ds50010--------
    rs1387690531,2
    C--64119475(+) TGAGGC/TGAAGC 2 -- ds50010--------
    rs1852581301,2
    --64119491(+) CACTTG/TATTTG 2 -- ds50010--------
    rs1403278391,2
    --64119512(+) CTGATG/TCTAAT 2 -- ds50010--------
    rs1503447891,2
    --64119644(+) ACTTAA/GAAACA 2 -- ds50010--------
    rs1380536141,2
    --64119711(+) AAGTAA/GGCAGA 2 -- ut310--------
    rs58316711,2
    C--64119864(+) TTTTT-/T/TT  
            
    AAGTA
    4 -- ut311NA 2
    rs1494818321,2
    C--64120011(+) GTCACG/TGAAAC 2 -- ut310--------

    HapMap Linkage Disequilibrium report for VPS54 (64119280 - 64246214 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for VPS54:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv874236CNV Loss21882294
    nsv521717CNV Gain19592680
    nsv7313OTHER Inversion18451855

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 614633    OMIM disorders: --

    4 diseases for VPS54:    About MalaCards
    hepatocellular carcinoma    lateral sclerosis    amyotrophic lateral sclerosis    malaria


    VPS54 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): VPS54
    Human Genome Epidemiology (HuGE) Navigator: VPS54 (2 documents)

    Export disorders for VPS54 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for VPS54 gene, integrated from 10 sources (see all 16):
    (articles sorted by number of sources associating them with VPS54)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    2. Ang2/fat-free is a conserved subunit of the Golgi-associated retrograde protein complex. (PubMed id 20685960)1, 2 Perez-Victoria F.J.... Bonifacino J.S. (Mol. Biol. Cell 2010)
    3. Requirement of the human GARP complex for mannose 6-phosphate- receptor-dependent sorting of cathepsin D to lysosomes. (PubMed id 18367545)1, 2 Perez-Victoria F.J.... Bonifacino J.S. (Mol. Biol. Cell 2008)
    4. Evaluation of the Golgi trafficking protein VPS54 (wobbler) as a candidate for ALS. (PubMed id 18574757)1, 4 Meisler M.H....Brown R.H. (Amyotroph Lateral Scler 2008)
    5. Characterization of the human GARP (Golgi associated retrograde protein) complex. (PubMed id 15878329)1, 2 Liewen H.... Stenner-Liewen F. (Exp. Cell Res. 2005)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. Identification, characterization and cytogenetic mapping of a yeast Vps54 homolog in rat and mouse. (PubMed id 12039048)1, 3 Walter L....GA1nther E. (Gene 2002)
    9. Dual roles of the mammalian GARP complex in tethering and SNARE complex assembly at the trans-golgi network. (PubMed id 19620288)1, 9 PAcrez-Victoria F.J. and Bonifacino J.S. (Mol. Cell. Biol. 2009)
    10. VPS54 genetic analysis in ALS Italian cohort. (PubMed id 21087364)1 Corrado L....D'Alfonso S. (Eur. J. Neurol. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 51542 HGNC: 18652 AceView: VPS54 Ensembl:ENSG00000143952 euGenes: HUgn51542
    ECgene: VPS54 H-InvDB: VPS54

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for VPS54 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for VPS54 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for VPS54 gene:
    Search GeneIP for patents involving VPS54

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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