Aliases for VPS54 Gene
External Ids for VPS54 Gene
Previous GeneCards Identifiers for VPS54 Gene
This gene encodes for a protein that in yeast forms part of a trimeric vacuolar-protein-sorting complex that is required for retrograde transport of proteins from prevacuoles to the late Golgi compartment. As in yeast, mammalian Vps54 proteins contain a coiled-coil region and dileucine motifs. Alternative splicing results in multiple transcript variants encoding different isoforms [provided by RefSeq, Jul 2008]
GeneCards Summary for VPS54 Gene
VPS54 (Vacuolar Protein Sorting 54 Homolog (S. Cerevisiae)) is a Protein Coding gene. Diseases associated with VPS54 include hepatocellular carcinoma.
UniProtKB/Swiss-Prot for VPS54 Gene
May be involved in retrograde transport from early and late endosomes to the late Golgi. The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD.