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VPS53 Gene

protein-coding   GIFtS: 52
GCID: GC17M000381

Vacuolar Protein Sorting 53 Homolog (S. Cerevisiae)

(Previous name: vacuolar protein sorting 53 (yeast))
  See VPS53-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Vacuolar Protein Sorting 53 Homolog (S. Cerevisiae)1 2
Vacuolar Protein Sorting 53 (Yeast)1
HCCS12
hVps53L2
pp136242
Vacuolar Protein Sorting-Associated Protein 53 Homolog2

External Ids:    HGNC: 256081   Entrez Gene: 552752   Ensembl: ENSG000001412527   UniProtKB: Q5VIR63   

Export aliases for VPS53 gene to outside databases

Previous GC identifer: GC17M000366


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for VPS53 Gene:
This gene encodes a protein with sequence similarity to the yeast Vps53p protein. Vps53p is involved in retrograde
vesicle trafficking in late Golgi. (provided by RefSeq, Jul 2008)

GeneCards Summary for VPS53 Gene:
VPS53 (vacuolar protein sorting 53 homolog (S. cerevisiae)) is a protein-coding gene. Diseases associated with VPS53 include pontocerebellar hypoplasia, type 2e.

UniProtKB/Swiss-Prot: VPS53_HUMAN, Q5VIR6
Function: May be involved in retrograde transport of early and late endosomes to the late Golgi. The GARP complex
is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes,
this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NT_010718.17  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the VPS53 gene promoter:
         C/EBPbeta   ISGF-3   p53   POU3F1   MZF-1   CREB   NRF-2   FOXC1   Ik-2   deltaCREB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidVPS53 promoter sequence
   Search Chromatin IP Primers for VPS53

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat VPS53


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.3   Ensembl cytogenetic band:  17p13.3   HGNC cytogenetic band: 17p13.3

VPS53 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
VPS53 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M000381:  view genomic region     (about GC identifiers)

Start:
411,908 bp from pter      End:
624,957 bp from pter
Size:
213,050 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: VPS53_HUMAN, Q5VIR6 (See protein sequence)
Recommended Name: Vacuolar protein sorting-associated protein 53 homolog  
Size: 699 amino acids; 79653 Da
Subunit: Component of the Golgi-associated retrograde protein (GARP) complex, also called VFT (VPS fifty-three)
complex, composed of VPS51, VPS52, VPS53 and VPS54
Sequence caution: Sequence=AAL55842.1; Type=Frameshift; Positions=562;
Secondary accessions: A8K2S8 B3FH42 Q8WYW3 Q9BRR2 Q9BY02 Q9NV25
Alternative splicing: 4 isoforms:  Q5VIR6-1   Q5VIR6-2   Q5VIR6-3   Q5VIR6-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for VPS53: NX_Q5VIR6

Explore proteomics data for VPS53 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys102
  • Modification sites at PhosphoSitePlus

  • See VPS53 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001121631.1  NP_060759.2  

    ENSEMBL proteins: 
     ENSP00000401435   ENSP00000459159   ENSP00000458311   ENSP00000291074   ENSP00000459312  
     ENSP00000384294   ENSP00000373692   ENSP00000458651   ENSP00000461429   ENSP00000394386  

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    Cloud-Clone Corp. Proteins for VPS53

     
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    antibodies-online proteins for VPS53 (2 products) 

     
    antibodies-online peptides for VPS53

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR007234 Vps53_N

    Graphical View of Domain Structure for InterPro Entry Q5VIR6

    ProtoNet protein and cluster: Q5VIR6

    2 Blocks protein domains:
    IPB007234 Vps53-like
    IPB011072 Protein kinase PKN/PRK1


    UniProtKB/Swiss-Prot: VPS53_HUMAN, Q5VIR6
    Similarity: Belongs to the VPS53 family


    Find genes that share domains with VPS53           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: VPS53_HUMAN, Q5VIR6
    Function: May be involved in retrograde transport of early and late endosomes to the late Golgi. The GARP complex
    is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes,
    this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
         
    Find genes that share ontologies with VPS53           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for VPS53:
     Decreased p24 protein expressi  Synthetic lethal with Ras 

         3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Vps53):
     embryogenesis  growth/size/body  mortality/aging 

    Find genes that share phenotypes with VPS53           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Vps53tm1Xtz for VPS53

       genOway: Develop your customized and physiologically relevant rodent model for VPS53

    miRNA
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    miRTarBase miRNAs that target VPS53:
    hsa-mir-877-3p (MIRT036899), hsa-mir-221-3p (MIRT046870), hsa-mir-1 (MIRT023608), hsa-mir-28-3p (MIRT038949), hsa-mir-328-3p (MIRT043781)

    Block miRNA regulation of human, mouse, rat VPS53 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate VPS53 (see all 112):
    hsa-miR-26a-2* hsa-miR-1321 hsa-miR-188-5p hsa-miR-411 hsa-miR-578 hsa-miR-3138 hsa-miR-632 hsa-miR-4267
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    Sino Biological Human cDNA Clone for VPS53
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    VPS53_HUMAN, Q5VIR6: Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Endosome
    membrane; Peripheral membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endosome5
    golgi apparatus5
    cytosol2
    nucleus1
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000938GARP complex IDA19620288
    GO:0010008endosome membrane IEA--
    GO:0016020membrane ----

    Find genes that share ontologies with VPS53           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for VPS53
    Interactions:

        Search GeneGlobe Interaction Network for VPS53

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for VPS53 (Q5VIR63 ENSP000004014354) via UniProtKB, MINT, STRING, and/or I2D (see all 88)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000236014Q8N1B43, ENSP000004069884I2D: score=8 STRING: ENSP00000406988
    ENSG00000206286Q8N1B43I2D: score=8 
    ENSG00000224455Q8N1B43I2D: score=8 
    ENSG00000225590Q8N1B43I2D: score=8 
    ENSG00000228425Q8N1B43I2D: score=8 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0015031protein transport IEA--
    GO:0016192vesicle-mediated transport ----

    Find genes that share ontologies with VPS53           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for VPS53



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for VPS53 gene (2 alternative transcripts): 
    NM_001128159.2  NM_018289.3  

    Unigene Cluster for VPS53:

    Vacuolar protein sorting 53 homolog (S. cerevisiae)
    Hs.461819  [show with all ESTs]
    Unigene Representative Sequence: NM_001128159
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 21):
    ENST00000437048(uc002frk.3 uc010cjo.2) ENST00000574029 ENST00000576149
    ENST00000541903 ENST00000570771 ENST00000573028 ENST00000291074 ENST00000571805
    ENST00000401468 ENST00000389040 ENST00000570359 ENST00000572607 ENST00000570650
    ENST00000572334 ENST00000576019 ENST00000575207 ENST00000575100 ENST00000572259

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate VPS53 (see all 112):
    hsa-miR-26a-2* hsa-miR-1321 hsa-miR-188-5p hsa-miR-411 hsa-miR-578 hsa-miR-3138 hsa-miR-632 hsa-miR-4267
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat VPS53
      QuantiTect SYBR Green Assays in human, mouse, rat VPS53
      QuantiFast Probe-based Assays in human, mouse, rat VPS53

    Additional mRNA sequence: 

    AF085927.1 AF246287.1 AF318335.1 AK001841.1 AK056323.1 AK057942.1 AK091388.1 AK092532.1 
    AK123107.1 AK128440.1 AK290343.1 AK299543.1 AY444797.1 BC006116.1 BC029560.1 BC039432.1 
    BC040223.1 EU021218.1 EU434648.1 EU434649.1 EU434650.1 

    Selected DOTS entries (see all 27):

    DT.209272  DT.430832  DT.99998592  DT.100758333  DT.304977  DT.100758332  DT.100707663  DT.100000719 
    DT.100656744  DT.101979882  DT.101967373  DT.120982107  DT.100019710  DT.433823  DT.97787599  DT.120982041 
    DT.40308713  DT.410961  DT.91842245  DT.95179598  DT.97823576  DT.99942465  DT.99943791  DT.100703187 

    Selected AceView cDNA sequences (see all 208):

    N49378 CB851054 CB105072 AI124779 BC006116 AI219542 Z41988 AK123107 
    BQ440533 NM_018289 BM458016 BM991403 AI524798 BM783166 BQ934744 AI399858 
    BM264094 BM797690 AI692376 AW293913 BX094584 AL701573 BM715665 AK128440 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for VPS53    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23a · 23b ^ 24 ^ 25 ^
    SP1:        -                       -                                                           -                                                               
    SP2:                                      -     -     -     -                                                                                   -               
    SP3:                                                                                                                                                            

    ExUns: 26
    SP1:      
    SP2:      
    SP3:      


    ECgene alternative splicing isoforms for VPS53

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    VPS53 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCTGTAGTCG
    VPS53 Expression
    About this image

    VPS53 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    VPS53 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.461819
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for VPS53 gene from Selected species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Vps531 , 5 vacuolar protein sorting 53 (yeast)1, 5 89.45(n)1
    96.7(a)1
      11 (45.92 cM)5
    682991  NM_026664.31  NP_080940.21 
     760462265 
    chicken
    (Gallus gallus)
    Aves VPS531 vacuolar protein sorting 53 homolog (S. cerevisiae) 82.52(n)
    93.64(a)
      417622  NM_001012806.1  NP_001012824.1 
    lizard
    (Anolis carolinensis)
    Reptilia VPS536
    vacuolar protein sorting 53 homolog (S. cerevisiae...
    91(a)
    1 ↔ 1
    GL343543.1(473467-526347)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004961101 vacuolar protein sorting-associated protein 53 homolog 75.16(n)
    88.97(a)
      100496110  XM_002934343.2  XP_002934389.2 
    zebrafish
    (Danio rerio)
    Actinopterygii vps531 vacuolar protein sorting 53 homolog (S. cerevisiae) 77.87(n)
    90.43(a)
      492817  NM_001007458.2  NP_001007459.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG33381 CG3338 57.93(n)
    53.72(a)
      33640  NM_134981.3  NP_608825.2 
    worm
    (Caenorhabditis elegans)
    Secernentea vps-531 vps-53 49.37(n)
    41.72(a)
      176377  NM_001268098.1  NP_001255027.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes VPS536
    Component of the GARP (Golgi-associated retrograde...
    21(a)
    1 ↔ 1
    X(388385-390853) YJL029C
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons HIT11 HIT1 48.66(n)
    36.6(a)
      841472  NM_103933.5  NP_564573.3 
    rice
    (Oryza sativa)
    Liliopsida Os01g09062001 Os01g0906200 47.9(n)
    36.31(a)
      4324975  NM_001051667.1  NP_001045132.2 


    ENSEMBL Gene Tree for VPS53 (if available)
    TreeFam Gene Tree for VPS53 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for VPS53 gene
    8 SIMAP similar genes for VPS53 using alignment to 11 protein entries:     VPS53_HUMAN (see all proteins):
    LIN7B    A4GALT    HCCS1    SKA1    C8orf44    LOC100287164
    SNTB2    PS1TP4

    Find genes that share paralogs with VPS53           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for VPS53
    PGOHUM00000234903


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for VPS53 (see all 5252)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs720107061,2
    C--332782(+) CTGCT-/TTTTT 
     
    /TTTTTT
    TTTTT
    2 -- ut31 cds10--------
    rs668551021,2
    C--406741(+) TTTGT-/CTAACTC 2 -- int11Minor allele frequency- CT:0.00NA 2
    rs751971011,2
    C--411408(+) ACATAT/CTCCAA 1 -- ds50013Minor allele frequency- C:0.12CSA WA EA 239
    rs774645321,2
    C,F--411442(+) AAACAC/TTCCTG 1 -- ds50011Minor allele frequency- T:0.01WA 118
    rs1425870741,2
    C--411648(+) GCTTC-/CAAA  
            
    CAGAC
    1 -- ds50010--------
    rs1839333761,2
    --411732(+) ACTTCA/GCTTTT 1 -- ds50010--------
    rs801226701,2
    C,F--411789(+) AATAAC/TGCAAC 1 -- ds50012Minor allele frequency- T:0.05CSA WA 119
    rs1891843941,2
    --411795(+) GCAACA/GCGCAT 1 -- ds50010--------
    rs1922426261,2
    --411808(+) TCAAAC/TGTCTT 1 -- ds50010--------
    rs1148918361,2
    C,F--411880(+) GTTCAC/TGGCCA 1 -- ds50011Minor allele frequency- T:0.02WA 118

    HapMap Linkage Disequilibrium report for VPS53 (411908 - 624957 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for VPS53 (see all 83):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2715337CNV Deletion23290073
    esv2715316CNV Deletion23290073
    esv997699CNV Deletion20482838
    esv1357787CNV Deletion17803354
    esv2715335CNV Deletion23290073
    esv2715317CNV Deletion23290073
    esv2715313CNV Deletion23290073
    esv2715325CNV Deletion23290073
    esv1330743CNV Deletion17803354
    esv2661341CNV Deletion23128226

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    1 disease for VPS53:    
    About MalaCards
    pontocerebellar hypoplasia, type 2e


    Find genes that share disorders with VPS53           About GenesLikeMe

    Genetic Association Database (GAD): VPS53
    Human Genome Epidemiology (HuGE) Navigator: VPS53 (1 document)

    Export disorders for VPS53 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for VPS53 gene, integrated from 10 sources (see all 26):
    (articles sorted by number of sources associating them with VPS53)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of the human GARP (Golgi associated retrograde protein) complex. (PubMed id 15878329)1, 2, 3 Liewen H.... Stenner-Liewen F. (Exp. Cell Res. 2005)
    2. Ang2/fat-free is a conserved subunit of the Golgi-associated retrograde protein complex. (PubMed id 20685960)1, 2 Perez-Victoria F.J.... Bonifacino J.S. (Mol. Biol. Cell 2010)
    3. Requirement of the human GARP complex for mannose 6-phosphate- receptor-dependent sorting of cathepsin D to lysosomes. (PubMed id 18367545)1, 2 Perez-Victoria F.J.... Bonifacino J.S. (Mol. Biol. Cell 2008)
    4. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PubMed id 15498874)1, 2 Wan D....Gu J. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. The minimum LOH region defined on chromosome 17p13.3 in human hepatocellular carcinoma with gene content analysis. (PubMed id 12565177)1, 2 Zhao X.... Gu J. (Cancer Lett. 2003)
    8. Dual roles of the mammalian GARP complex in tethering and SNARE complex assembly at the trans-golgi network. (PubMed id 19620288)1, 9 PAcrez-Victoria F.J. and Bonifacino J.S. (Mol. Cell. Biol. 2009)
    9. VCP phosphorylation-dependent interaction partners prevent apoptosis in Helicobacter pylori-infected gastric epithelial cells. (PubMed id 23383273)1 Yu C.C....Chow L.P. (PLoS ONE 2013)
    10. Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. (PubMed id 23535732)1 Eeles R.A....Easton D.F. (Nat. Genet. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 55275 HGNC: 25608 AceView: FLJ10979 Ensembl:ENSG00000141252 euGenes: HUgn55275
    ECgene: VPS53 H-InvDB: VPS53

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for VPS53 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for VPS53 gene:
    Search GeneIP for patents involving VPS53

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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