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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

VPS52 Gene

protein-coding   GIFtS: 49
GCID: GC06M033218

Vacuolar Protein Sorting 52 Homolog (S. Cerevisiae)

(Previous names: SAC2 suppressor of actin mutations 2-like (yeast), vacuolar...)
(Previous symbol: SACM2L)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Vacuolar Protein Sorting 52 Homolog (S. Cerevisiae)1 2     ARE12
SACM2L1 2 3 5     RP5-1033B102
SAC2 Suppressor Of Actin Mutations 2-Like Protein2 3     SAC22
SAC2 Suppressor Of Actin Mutations 2-Like (Yeast)1     dJ1033B10.52
Vacuolar Protein Sorting 52 (Yeast)1     Vacuolar Protein Sorting-Associated Protein 52 Homolog2

External Ids:    HGNC: 105181   Entrez Gene: 62932   Ensembl: ENSG000002235017   OMIM: 6034435   UniProtKB: Q8N1B43   

Export aliases for VPS52 gene to outside databases

Previous GC identifers: GC06M033210 GC06M033264 GC06M033326 GC06M032960


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for VPS52 Gene:
This gene encodes a protein that is similar to the yeast suppressor of actin mutations 2 gene. The yeast protein
forms a subunit of the tetrameric Golgi-associated retrograde protein complex that is involved in vesicle
trafficking from from both early and late endosomes, back to the trans-Golgi network. This gene is located on
chromosome 6 in a head-to-head orientation with the gene encoding ribosomal protein S18. (provided by RefSeq, Jul
2008)

GeneCards Summary for VPS52 Gene: 
VPS52 (vacuolar protein sorting 52 homolog (S. cerevisiae)) is a protein-coding gene. Diseases associated with VPS52 include azoospermia, and macular degeneration. GO annotations related to this gene include protein binding.

UniProtKB/Swiss-Prot: VPS52_HUMAN, Q8N1B4
Function: May be involved in retrograde transport of early and late endosomes to the late Golgi. The GARP complex
is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes,
this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD

Gene Wiki entry for VPS52 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NT_007592.15  NT_113891.2  NT_167245.1  NT_167247.1  NT_167248.1  NT_167249.1  NC_018917.2  
NT_167246.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the VPS52 gene promoter:
         ER-alpha   p53   AP-1   ATF-2   Olf-1   Meis-1b   HNF-4alpha1   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidVPS52 promoter sequence
   Search SABiosciences Chromatin IP Primers for VPS52

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat VPS52


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3   Ensembl cytogenetic band:  6p21.32   HGNC cytogenetic band: 6p21.3

VPS52 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
VPS52 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M033218:  view genomic region     (about GC identifiers)

Start:
33,218,049 bp from pter      End:
33,239,824 bp from pter
Size:
21,776 bases      Orientation:
minus strand

6 alternative locations:
Chr6-,NT_113891.2 4,661,875-4,683,472      Chr6-,NT_167247 4,691,839-4,713,432      Chr6-,NT_167249 4,698,274-4,719,864     
Chr6-,NT_167246 4,675,353-4,677,055      Chr6-,NT_167245 4,499,369-4,520,984      Chr6-,NT_167248 4,450,268-4,471,898     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: VPS52_HUMAN, Q8N1B4 (See protein sequence)
Recommended Name: Vacuolar protein sorting-associated protein 52 homolog  
Size: 723 amino acids; 82221 Da
Subunit: Component of the Golgi-associated retrograde protein (GARP) complex, also called VFT (VPS fifty-three)
complex, composed of VPS51, VPS52, VPS53 and VPS54. Interacts with RAB6A and STX10
Subcellular location: Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Endosome
membrane; Peripheral membrane protein
Sequence caution: Sequence=CAI95619.1; Type=Erroneous gene model prediction;
Secondary accessions: A2BF38 B0UZZ4 Q53GR4 Q5JPA0 Q5SQW1 Q8IUN6 Q9NPT5

Explore the universe of human proteins at neXtProt for VPS52: NX_Q8N1B4

Explore proteomics data for VPS52 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8N1B4

  • VPS52 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    VPS52 Protein Expression
    REFSEQ proteins: NP_072047.4  
    ENSEMBL proteins: 
     ENSP00000436612   ENSP00000409952   ENSP00000395282  

    Human Recombinant Protein Products for VPS52: 
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    Novus Biologicals VPS52 Proteins
    Novus Biologicals VPS52 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for VPS52 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005794Golgi apparatus IEA--
    GO:0010008endosome membrane IEA--

    VPS52 for ontologies           About GeneDecksing



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    Cloud-Clone Corp. ELISAs for VPS52 
    Cloud-Clone Corp. CLIAs for VPS52


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR007258 Vps52

    Graphical View of Domain Structure for InterPro Entry Q8N1B4

    ProtoNet protein and cluster: Q8N1B4

    UniProtKB/Swiss-Prot: VPS52_HUMAN, Q8N1B4
    Similarity: Belongs to the VPS52 family


    VPS52 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: VPS52_HUMAN, Q8N1B4
    Function: May be involved in retrograde transport of early and late endosomes to the late Golgi. The GARP complex
    is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes,
    this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
         
    VPS52 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for VPS52:
     Increased gamma-H2AX phosphory 

         5 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Vps52):
     cardiovascular system  embryogenesis  growth/size  mortality/aging  normal 

    VPS52 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Vps52tm1.2Kab for VPS52

       inGenious Targeting Laboratory - Custom generated mouse model solutions for VPS52 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for VPS52

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for VPS52 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for VPS52 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat VPS52
    8 QIAGEN miScript miRNA Assays for microRNAs that regulate VPS52:
    hsa-miR-124* hsa-miR-1184 hsa-miR-544 hsa-miR-125a-3p hsa-miR-3613-3p hsa-miR-4255 hsa-miR-1827 hsa-miR-1205
    SwitchGear 3'UTR luciferase reporter plasmidVPS52 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VPS52


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for VPS52

    5/62 Interacting proteins for VPS52 (Q8N1B42, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 62)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    VPS53Q5VIR63I2D: score=8 
    ATP6V0D1P614213I2D: score=5 
    EIF2B2P497703I2D: score=5 
    SAR1BQ9Y6B63I2D: score=5 
    SDAD1Q9NVU73I2D: score=5 
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0010668ectodermal cell differentiation IEA--
    GO:0015031protein transport IEA--
    GO:0048611embryonic ectodermal digestive tract development IEA--

    VPS52 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for VPS52

    Search CenterWatch for drugs/clinical trials and news about VPS52

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for VPS52 gene: 
    NM_022553.4  

    Unigene Cluster for VPS52:

    Vacuolar protein sorting 52 homolog (S. cerevisiae)
    Hs.480356  [show with all ESTs]
    Unigene Representative Sequence: AK093057
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000482399(uc003odo.1) ENST00000445902(uc003odm.1 uc011dqz.1)
    ENST00000478934(uc003odn.1) ENST00000495981 ENST00000493674 ENST00000471309
    ENST00000461743 ENST00000493379 ENST00000495755 ENST00000463486 ENST00000464425
    ENST00000436044(uc011dqy.1)
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat VPS52
    8 QIAGEN miScript miRNA Assays for microRNAs that regulate VPS52:
    hsa-miR-124* hsa-miR-1184 hsa-miR-544 hsa-miR-125a-3p hsa-miR-3613-3p hsa-miR-4255 hsa-miR-1827 hsa-miR-1205
    SwitchGear 3'UTR luciferase reporter plasmidVPS52 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat VPS52
    Clone
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    GenScript: all cDNA clones in your preferred vector: VPS52 (NM_022553)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for VPS52
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VPS52
    Sirion Biotech Customized lentivirus for stable overexpression of VPS52 
                         Customized lentivirus expression plasmids for stable overexpression of VPS52 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for VPS52
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat VPS52
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat VPS52

    Additional mRNA sequence: 

    AJ006026.1 AK001725.1 AK093057.1 AK222867.1 AK297935.1 AK299563.1 AK300308.1 AK300430.1 
    AK304080.1 AL390171.1 BC032108.1 BC040114.1 

    22 DOTS entries:

    DT.100657026  DT.100872513  DT.121307939  DT.121307941  DT.100657029  DT.316371  DT.92441544  DT.92060210 
    DT.121308072  DT.121308068  DT.100688733  DT.95329711  DT.95329720  DT.100657028  DT.121307945  DT.121308017 
    DT.425507  DT.91696044  DT.95251824  DT.75119863  DT.95149522  DT.96085306 

    24/325 AceView cDNA sequences (see all 325):

    AW292339 BQ228285 AA961126 AI937084 BM705047 AA593405 BQ423280 BI091965 
    BQ022405 NM_022553 AA972254 NM_080564 AW292560 AW237668 BQ130065 BQ070593 
    AL134887 BQ889637 BF197439 AA454912 BX378838 CD512140 BI821081 BG680371 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    VPS52 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGCCTCCTC
    VPS52 Expression
    About this image


    See VPS52 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for VPS52

    SOURCE GeneReport for Unigene cluster: Hs.480356
        SABiosciences Custom PCR Arrays for VPS52
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VPS52

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for VPS52 gene from 9/22 species (see all 22)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Vps521 , 5 vacuolar protein sorting 52 (yeast)1, 5 88.98(n)1
    98.2(a)1
      17 (17.98 cM)5
    2247051  NM_172620.31  NP_766208.21 
     339558125 
    lizard
    (Anolis carolinensis)
    Reptilia VPS526
    Uncharacterized protein
    76(a)
    1 ↔ 1
    GL343857.1(32393-55125)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.115072 Xenopus laevis transcribed sequence with weak similarity more 76.85(n)    BU911662.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BM141619.12   -- 76.89(n)    BM141619.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG73711 CG7371 57.01(n)
    51.46(a)
      33774  NM_135087.2  NP_608931.1 
    worm
    (Caenorhabditis elegans)
    Secernentea vps-521 Protein VPS-52 46.33(n)
    36.01(a)
      181018  NM_076881.4  NP_509282.2 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes VPS521 Vps52p 38(n)
    24.22(a)
      852095   NP_010772.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons POK1 Vps52 / Sac2-like protein 48.8(n)
    36.08(a)
      843468  NM_105796.3  NP_565015.1 
    rice
    (Oryza sativa)
    Liliopsida Os03g04179001 hypothetical protein 47.42(n)
    36.48(a)
      4333120  NM_001056907.1  NP_001050372.1 


    ENSEMBL Gene Tree for VPS52 (if available)
    TreeFam Gene Tree for VPS52 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/343 SNPs in VPS52 are shown (see all 343)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1424454561,2
    C--33223169(+) GCCTTA/CATCTC 1 -- int10--------
    rs1151005991,2
    C,F--33223188(+) ATCCCG/ACCTCA 1 -- int11Minor allele frequency- A:0.03NA 120
    rs1125087031,2
    C--33223334(+) CAAGGC/TGGGCA 1 -- int11Minor allele frequency- T:0.50WA 2
    rs4180021,2
    C--33223425(-) tgcccG/Agtatt 1 -- int13Minor allele frequency- A:0.10NA EA 242
    rs2132181,2
    C,F,A,H--33223426(+) ataccG/Aggcat 1 -- int19Minor allele frequency- A:0.18NS EA WA NA 774
    rs4078191,2
    C--33223462(-) cctccC/Tgagta 1 -- int10--------
    rs122108021,2
    C,F,H--33223622(+) aggcaG/Aatccc 1 -- int18Minor allele frequency- A:0.06NS EA NA 1224
    rs2132191,2
    C,F,A--33223659(+) agagaT/Gtctcc 1 -- int16Minor allele frequency- G:0.40NA WA EA 364
    rs1131055591,2
    C,F--33223979(+) AGACTC/ATCTTA 1 -- int13Minor allele frequency- A:0.08CSA WA 122
    rs2003215141,2
    --33224085(+) TACAG-/AAAAAA 1 -- int10--------

    HapMap Linkage Disequilibrium report for VPS52 (33218049 - 33239824 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for VPS52:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv830634CNV Loss17160897
    nsv830635CNV Loss17160897
    nsv5249CNV Loss18451855

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing VPS52
    DNA2.0 Custom Variant and Variant Library Synthesis for VPS52

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 603443    OMIM disorders: --

    7 diseases for VPS52:    About MalaCards
    azoospermia    macular degeneration    ataxia    systemic lupus erythematosus
    lupus erythematosus    prostate cancer    prostatitis


    VPS52 for disorders           About GeneDecksing

    Genetic Association Database (GAD): VPS52
    Human Genome Epidemiology (HuGE) Navigator: VPS52 (4 documents)

    Export disorders for VPS52 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for VPS52 gene, integrated from 9 sources (see all 21):
    (articles sorted by number of sources associating them with VPS52)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a novel highly conserved gene in the centromeric part of the major histocompatibility complex. (PubMed id 9790748)1, 3, 9 Walter L. and Guenther E. (1998)
    2. Ang2/fat-free is a conserved subunit of the Golgi-ass ociated retrograde protein complex. (PubMed id 20685960)1, 2 PAcrez-Victoria F.J....Bonifacino J.S. (2010)
    3. High-density SNP screening of the major histocompatib ility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PubMed id 19851445)1, 4 Barcellos L.F....Criswell L.A. (2009)
    4. Requirement of the Human GARP Complex for Mannose 6-phosphate- receptor-dependent Sorting of Cathepsin D to Lysosomes. (PubMed id 18367545)1, 2 Perez-Victoria F.J.... Bonifacino J.S. (2008)
    5. Characterization of the human GARP (Golgi associated retrograde protein) complex. (PubMed id 15878329)1, 2 Liewen H.... Stenner-Liewen F. (2005)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
    8. Susceptibility locus for non-obstructive azoospermia is localized within the HLA-DR/DQ subregion: primary role of DQB1*0604. (PubMed id 12366783)1, 4 Matsuzaka Y....Inoko H. (2002)
    9. Linkage between polymorphisms in the prostate specific antigen ARE1 gene region, prostate cancer risk, and circulating tumor cells. (PubMed id 12210484)1, 4 Medeiros R....Lopes C. (2002)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6293 HGNC: 10518 AceView: VPS52 Ensembl:ENSG00000223501 euGenes: HUgn6293
    ECgene: VPS52 H-InvDB: VPS52

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for VPS52 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for VPS52 gene:
    Search GeneIP for patents involving VPS52

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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