Aliases for VPS52 Gene
Aliases for VPS52 Gene
External Ids for VPS52 Gene
- HGNC: 10518
- Entrez Gene: 6293
- Ensembl: ENSG00000223501
- OMIM: 603443
- UniProtKB: Q8N1B4
Previous HGNC Symbols for VPS52 Gene
- SACM2L
Previous GeneCards Identifiers for VPS52 Gene
- GC06M033210
- GC06M033264
- GC06M033326
- GC06M033218
- GC06M032960
Summaries for VPS52 Gene
-
This gene encodes a protein that is similar to the yeast suppressor of actin mutations 2 gene. The yeast protein forms a subunit of the tetrameric Golgi-associated retrograde protein complex that is involved in vesicle trafficking from from both early and late endosomes, back to the trans-Golgi network. This gene is located on chromosome 6 in a head-to-head orientation with the gene encoding ribosomal protein S18. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
GeneCards Summary for VPS52 Gene
VPS52 (VPS52, GARP Complex Subunit) is a Protein Coding gene. Among its related pathways are Vesicle-mediated transport and Golgi-to-ER retrograde transport. Gene Ontology (GO) annotations related to this gene include syntaxin binding.
UniProtKB/Swiss-Prot for VPS52 Gene
-
Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD (PubMed:15878329, PubMed:18367545). Acts as component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalized transferrin receptor (TFRC) to the plasma membrane (PubMed:25799061).
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VPS52 Gene
Genomics for VPS52 Gene
GeneHancer (GH) Regulatory Elements for VPS52 Gene
Promoters and enhancers for VPS52 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around VPS52 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for VPS52 Gene
Genomic Locations for VPS52 Gene
- chr6:33,250,272-33,272,047
- (GRCh38/hg38)
- Size:
- 21,776 bases
- Orientation:
- Minus strand
- chr6:33,218,049-33,239,824
- (GRCh37/hg19)
Genomic View for VPS52 Gene
Genes around VPS52 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 6p21.32 by Ensembl
- 6p21.32 by Entrez Gene
- 6p21.32 by HGNC
VPS52 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for VPS52 Gene
Proteins for VPS52 Gene
-
Protein details for VPS52 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8N1B4-VPS52_HUMAN
- Recommended name:
- Vacuolar protein sorting-associated protein 52 homolog
- Protein Accession:
- Q8N1B4
- A2BF38
- B0UZZ4
- B4DNI9
- Q53GR4
- Q5JPA0
- Q5SQW1
- Q8IUN6
- Q9NPT5
Protein attributes for VPS52 Gene
- Size:
- 723 amino acids
- Molecular mass:
- 82221 Da
- Quaternary structure:
-
- Component of the Golgi-associated retrograde protein (GARP) complex, also called VFT (VPS fifty-three) complex, composed of VPS51, VPS52, VPS53 and VPS54 (PubMed:15878329, PubMed:20685960). Component of the endosome-associated retrograde protein (EARP) complex, composed of VPS51, VPS52, VPS53 and VPS50/Syndetin (PubMed:25799061). Interacts with RAB6A and STX10 (PubMed:15878329, PubMed:20685960).
- SequenceCaution:
-
- Sequence=CAI95619.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
Protein Expression for VPS52 Gene
Post-translational modifications for VPS52 Gene
- Ubiquitination at isoforms=2205
Other Protein References for VPS52 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for VPS52
- Novus Biologicals Antibodies for VPS52
- Invitrogen Antibodies for VPS52
- antibodies-online: Search results for 31 available VPS52 Antibodies ranked by validation data
- Compare Top VPS52 Antibodies
-
Quality Products:
- ABIN2787317
- ABIN654879
- ABIN955527
- ABIN2745293
- ABIN4891586
- ABIN948440
- ABIN2386101
- ABIN2386104
- ABIN2386103
- ABIN2386106
- ABIN948440
- ABIN4891586
- ABIN2745293
- ABIN955527
- ABIN654879
- ABIN2787317
- ABIN2386101
- ABIN2386104
- ABIN2386103
- ABIN2386106
- ABIN948440
- ABIN4891586
- ABIN2745293
- ABIN955527
- ABIN654879
- ABIN2787317
- ABIN2386101
- ABIN2386104
- ABIN2386103
- ABIN2386106
- GeneTex VPS52 antibody for VPS52
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for VPS52
- Origene Custom Protein Services for VPS52
- Search GeneTex for Proteins for VPS52
-
Abcam proteins for VPS52
Assay Products
No data available for DME Specific Peptides for VPS52 Gene
Domains & Families for VPS52 Gene
Gene Families for VPS52 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Suggested Antigen Peptide Sequences for VPS52 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q8N1B4- Family:
-
- Belongs to the VPS52 family.
Function for VPS52 Gene
Molecular function for VPS52 Gene
- UniProtKB/Swiss-Prot Function:
- Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD (PubMed:15878329, PubMed:18367545). Acts as component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalized transferrin receptor (TFRC) to the plasma membrane (PubMed:25799061).
Phenotypes From GWAS Catalog for VPS52 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 15878329 |
| GO:0017137 | Rab GTPase binding | IBA | -- |
| GO:0019905 | syntaxin binding | IPI | 15878329 |
Phenotypes for VPS52 Gene
- MGI mutant phenotypes for VPS52:
- inferred from 4 alleles
- GenomeRNAi human phenotypes for VPS52:
Animal Models for VPS52 Gene
- MGI Knock Outs for VPS52:
-
- Vps52 tm1.2Kab
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for VPS52
-
-
ViGene Biosciences lentiviral particle packaged cDNA for VPS52 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for VPS52 gene
- Search ViGene Biosciences for VPS52
CRISPR Products
-
OriGene CRISPR knockouts for VPS52
- genomics-online: gRNA clones - Search results for 100 available VPS52 gene related products
- Overview of 100 available VPS52 gene related products
-
Recommended
- pGFP-V-RS
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pLenti-U6-sgRNA-PGK-Neo
- pDONR223
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pCMV6-Entry
- pCMV6-XL5
- pGFP-V-RS
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pLenti-U6-sgRNA-PGK-Neo
- pDONR223
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pCMV6-Entry
- pCMV6-XL5
- pGFP-V-RS
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pLenti-U6-sgRNA-PGK-Neo
- pDONR223
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pCMV6-Entry
- pCMV6-XL5
- Applied Biological Materials CRISPR for VPS52
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for VPS52
- GenScript: Design CRISPR guide RNA sequences for VPS52
miRNA for VPS52 Gene
- miRTarBase miRNAs that target VPS52
-
- hsa-mir-4728-5p (MIRT491942)
- hsa-mir-607 (MIRT491943)
- hsa-mir-3591-5p (MIRT491944)
- hsa-mir-628-5p (MIRT491945)
- hsa-mir-3671 (MIRT491946)
- hsa-mir-6807-5p (MIRT491947)
- hsa-mir-124-5p (MIRT491948)
- hsa-mir-3175 (MIRT491949)
- hsa-mir-6731-5p (MIRT491950)
- hsa-mir-8085 (MIRT491951)
- hsa-mir-8077 (MIRT491952)
- hsa-mir-7160-5p (MIRT491953)
- hsa-mir-655-5p (MIRT491954)
- hsa-mir-4663 (MIRT491955)
- hsa-mir-665 (MIRT491956)
- hsa-mir-4459 (MIRT491957)
- hsa-mir-4779 (MIRT491958)
- hsa-mir-4255 (MIRT491959)
- hsa-mir-7161-3p (MIRT491960)
- hsa-mir-302f (MIRT491961)
- hsa-mir-142-3p (MIRT491962)
- hsa-mir-513b-5p (MIRT651663)
- hsa-mir-6829-3p (MIRT651664)
- hsa-mir-6791-3p (MIRT651665)
- hsa-mir-4252 (MIRT651666)
- hsa-mir-205-5p (MIRT651667)
- hsa-mir-4719 (MIRT651668)
- hsa-mir-7853-5p (MIRT651669)
- hsa-mir-105-5p (MIRT651670)
- hsa-mir-330-3p (MIRT651671)
- hsa-mir-7109-3p (MIRT651672)
- hsa-mir-6771-3p (MIRT651673)
- hsa-mir-3065-3p (MIRT739710)
- hsa-mir-338-3p (MIRT741358)
- hsa-mir-3617-3p (MIRT741700)
- hsa-mir-383-3p (MIRT742804)
- hsa-mir-500b-3p (MIRT749476)
- hsa-mir-6884-3p (MIRT758496)
- hsa-mir-7156-3p (MIRT759274)
miRNA Products
- Search ViGene Biosciences for VPS52
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for VPS52
- Browse OriGene Inhibitory RNA Products For VPS52
- genomics-online: shRNA clones - Search results for 100 available VPS52 gene related products
- Overview of 100 available VPS52 gene related products
-
Recommended
- pGFP-V-RS
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pLenti-U6-sgRNA-PGK-Neo
- pDONR223
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pCMV6-Entry
- pCMV6-XL5
- pGFP-V-RS
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pLenti-U6-sgRNA-PGK-Neo
- pDONR223
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pCMV6-Entry
- pCMV6-XL5
- pGFP-V-RS
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pLenti-U6-sgRNA-PGK-Neo
- pDONR223
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pCMV6-Entry
- pCMV6-XL5
-
ViGene Biosciences ready-to-package AAV shRNAs for VPS52 gene
Clone Products
-
GenScript: Next-day shipping of latest version cDNA ORF clones for VPS52 in any vector
- NM_001289175.1
- XM_011547675.1
- XM_011548073.1
- XM_011548261.1
- XM_011514797.1
- XM_011548264.1
- XM_011514800.1
- XM_011548458.1
- XM_011547272.1
- NM_001289174.1
- XM_011547674.1
- XM_011548072.1
- XM_011548075.1
- XM_011548263.1
- XM_011514799.1
- XM_011548457.1
- XM_011547271.1
- NM_022553.5
- XM_011547673.1
- NM_001289176.1
- XM_011547676.1
- XM_011548074.1
- XM_011548262.1
- XM_011514798.1
- XM_011548456.1
- XM_011547270.1
- XM_011548459.1
- XM_011547273.1
- Sino Biological Human cDNA Clone for VPS52
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for VPS52
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for VPS52
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for 100 available VPS52 gene related products
- Overview of 100 available VPS52 gene related products
-
Recommended
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pCMV6-Entry
- pCMV6-XL5
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pCMV6-Entry
- pCMV6-XL5
- pGFP-V-RS
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pLenti-U6-sgRNA-PGK-Neo
- pDONR223
- pGFP-V-RS
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pLenti-U6-sgRNA-PGK-Neo
- pDONR223
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pCMV6-Entry
- pCMV6-XL5
- pGFP-V-RS
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pLenti-U6-sgRNA-PGK-Neo
- pDONR223
- orf clones - Search results for 100 available VPS52 gene related products
- Overview of 100 available VPS52 gene related products
-
Recommended
- pGFP-V-RS
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pLenti-U6-sgRNA-PGK-Neo
- pDONR223
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pCMV6-Entry
- pCMV6-XL5
- pGFP-V-RS
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pLenti-U6-sgRNA-PGK-Neo
- pDONR223
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pCMV6-Entry
- pCMV6-XL5
- pGFP-V-RS
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pLenti-U6-sgRNA-PGK-Neo
- pDONR223
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pCMV6-Entry
- pCMV6-XL5
- Applied Biological Materials Clones for VPS52
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for VPS52
-
ViGene Biosciences adenoviral particle packaged cDNA for VPS52 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for VPS52 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for VPS52 gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for VPS52 Gene
Localization for VPS52 Gene
Subcellular locations from UniProtKB/Swiss-Prot for VPS52 Gene
- Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein. Recycling endosome. Note=Localizes to the trans-Golgi network as part of the GARP complex, while it localizes to recycling endosomes as part of the EARP complex (PubMed:25799061). {ECO:0000269 PubMed:25799061}.
| Compartment | Confidence |
|---|---|
| golgi apparatus | 5 |
| endosome | 5 |
| cytosol | 3 |
| plasma membrane | 1 |
| mitochondrion | 1 |
| peroxisome | 1 |
| nucleus | 1 |
| endoplasmic reticulum | 1 |
| lysosome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000938 | GARP complex | IDA | 25799061 |
| GO:0005768 | endosome | IEA | -- |
| GO:0005794 | Golgi apparatus | IDA,IEA | 15878329 |
| GO:0005829 | cytosol | IEA | -- |
| GO:0010008 | endosome membrane | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for VPS52 Gene
Pathways & Interactions for VPS52 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Vesicle-mediated transport | ||
| 2 | Golgi-to-ER retrograde transport | ||
| 3 | Retrograde transport at the Trans-Golgi-Network | ||
Pathways by source for VPS52 Gene
4 Reactome pathways for VPS52 Gene
Interacting Proteins for VPS52 Gene
Selected Interacting proteins:
ENSP00000409952
Q8N1B4-VPS52_HUMAN
for VPS52 Gene via
STRING
MINT
UniProtKB
IID
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006810 | transport | IEA | -- |
| GO:0006896 | Golgi to vacuole transport | IBA | -- |
| GO:0007041 | lysosomal transport | IDA | 25799061 |
| GO:0010668 | ectodermal cell differentiation | IEA | -- |
| GO:0015031 | protein transport | IEA | -- |
No data available for SIGNOR curated interactions for VPS52 Gene
Transcripts for VPS52 Gene
mRNA/cDNA for VPS52 Gene
- (10) REFSEQ mRNAs :
- (12) Additional mRNA sequences :
- (325) Selected AceView cDNA sequences:
- (11) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for VPS52 Gene
CRISPR Products
-
OriGene CRISPR knockouts for VPS52
- genomics-online: gRNA clones - Search results for 100 available VPS52 gene related products
- Overview of 100 available VPS52 gene related products
-
Recommended
- pGFP-V-RS
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pLenti-U6-sgRNA-PGK-Neo
- pDONR223
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pCMV6-Entry
- pCMV6-XL5
- pGFP-V-RS
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pLenti-U6-sgRNA-PGK-Neo
- pDONR223
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pCMV6-Entry
- pCMV6-XL5
- pGFP-V-RS
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pLenti-U6-sgRNA-PGK-Neo
- pDONR223
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pCMV6-Entry
- pCMV6-XL5
- Applied Biological Materials CRISPR for VPS52
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for VPS52
- GenScript: Design CRISPR guide RNA sequences for VPS52
miRNA Products
- Search ViGene Biosciences for VPS52
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for VPS52
- Browse OriGene Inhibitory RNA Products For VPS52
- genomics-online: shRNA clones - Search results for 100 available VPS52 gene related products
- Overview of 100 available VPS52 gene related products
-
Recommended
- pGFP-V-RS
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pLenti-U6-sgRNA-PGK-Neo
- pDONR223
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pCMV6-Entry
- pCMV6-XL5
- pGFP-V-RS
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pLenti-U6-sgRNA-PGK-Neo
- pDONR223
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pCMV6-Entry
- pCMV6-XL5
- pGFP-V-RS
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pLenti-U6-sgRNA-PGK-Neo
- pDONR223
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pCMV6-Entry
- pCMV6-XL5
-
ViGene Biosciences ready-to-package AAV shRNAs for VPS52 gene
Clone Products
-
GenScript: Next-day shipping of latest version cDNA ORF clones for VPS52 in any vector
- NM_001289175.1
- XM_011547675.1
- XM_011548073.1
- XM_011548261.1
- XM_011514797.1
- XM_011548264.1
- XM_011514800.1
- XM_011548458.1
- XM_011547272.1
- NM_001289174.1
- XM_011547674.1
- XM_011548072.1
- XM_011548075.1
- XM_011548263.1
- XM_011514799.1
- XM_011548457.1
- XM_011547271.1
- NM_022553.5
- XM_011547673.1
- NM_001289176.1
- XM_011547676.1
- XM_011548074.1
- XM_011548262.1
- XM_011514798.1
- XM_011548456.1
- XM_011547270.1
- XM_011548459.1
- XM_011547273.1
- Sino Biological Human cDNA Clone for VPS52
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for VPS52
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for VPS52
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for 100 available VPS52 gene related products
- Overview of 100 available VPS52 gene related products
-
Recommended
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pCMV6-Entry
- pCMV6-XL5
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pCMV6-Entry
- pCMV6-XL5
- pGFP-V-RS
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pLenti-U6-sgRNA-PGK-Neo
- pDONR223
- pGFP-V-RS
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pLenti-U6-sgRNA-PGK-Neo
- pDONR223
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pCMV6-Entry
- pCMV6-XL5
- pGFP-V-RS
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pLenti-U6-sgRNA-PGK-Neo
- pDONR223
- orf clones - Search results for 100 available VPS52 gene related products
- Overview of 100 available VPS52 gene related products
-
Recommended
- pGFP-V-RS
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pLenti-U6-sgRNA-PGK-Neo
- pDONR223
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pCMV6-Entry
- pCMV6-XL5
- pGFP-V-RS
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pLenti-U6-sgRNA-PGK-Neo
- pDONR223
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pCMV6-Entry
- pCMV6-XL5
- pGFP-V-RS
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pLenti-U6-sgRNA-PGK-Neo
- pDONR223
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pCMV6-Entry
- pCMV6-XL5
- Applied Biological Materials Clones for VPS52
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for VPS52 Gene
This gene is overexpressed in Peripheral blood mononuclear cells (12.7) and Bone (9.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for VPS52 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of VPS52 Gene:
VPS52SOURCE GeneReport for Unigene cluster for VPS52 Gene:
Hs.480356Evidence on tissue expression from TISSUES for VPS52 Gene
- Nervous system(4.9)
- Liver(4.5)
- Intestine(4.4)
- Skin(3)
- Muscle(2.4)
- Kidney(2.3)
Primer Products
-
OriGene qPCR primer pairs for VPS52
-
OriGene qPCR primer pairs and template standards for VPS52
- genomics-online: primer clones - Search results for 100 available VPS52 gene related products
- Overview of 100 available VPS52 gene related products
-
Recommended
- pGFP-V-RS
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pLenti-U6-sgRNA-PGK-Neo
- pDONR223
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pCMV6-Entry
- pCMV6-XL5
- pGFP-V-RS
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pLenti-U6-sgRNA-PGK-Neo
- pDONR223
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pCMV6-Entry
- pCMV6-XL5
- pGFP-V-RS
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pLenti-U6-sgRNA-PGK-Neo
- pDONR223
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pCMV6-Entry
- pCMV6-XL5
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for VPS52 Gene
Orthologs for VPS52 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | VPS52 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | VPS52 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | VPS52 33 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | -- 34 |
|
OneToMany | |
| -- 34 |
|
OneToMany | |||
| mouse (Mus musculus) |
Mammalia | Vps52 33 16 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Vps52 33 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | VPS52 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | vps52 33 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.11507 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | vps52 33 34 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | CG7371 33 34 |
|
||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP009739 33 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | vps-52 33 34 |
|
||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | VPS52 34 |
|
OneToOne | |
| thale cress (Arabidopsis thaliana) |
eudicotyledons | POK 33 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os03g0417900 33 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.6752 34 |
|
OneToOne | |
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.7505 33 |
|
- Species where no ortholog for VPS52 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for VPS52 Gene
No data available for Paralogs for VPS52 Gene
Variants for VPS52 Gene
| SNP ID | Clin | Chr 06 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000532472 | -- | 33,257,018(-) | G/T | genic_downstream_transcript_variant, intron_variant | |
| rs1000730962 | -- | 33,264,492(-) | C/G | coding_sequence_variant, genic_downstream_transcript_variant, missense_variant | |
| rs1000779401 | -- | 33,250,292(-) | A/G | 3_prime_UTR_variant, genic_downstream_transcript_variant | |
| rs1000807229 | -- | 33,269,923(-) | A/C | intron_variant | |
| rs1001184413 | -- | 33,264,132(-) | C/G | genic_downstream_transcript_variant, intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv10609n54 | CNV | loss | 21841781 |
| nsv1073969 | CNV | deletion | 25765185 |
| nsv1112900 | CNV | deletion | 24896259 |
| nsv1119076 | CNV | deletion | 24896259 |
| nsv5249 | CNV | deletion | 18451855 |
| nsv830634 | CNV | loss | 17160897 |
| nsv830635 | CNV | loss | 17160897 |
Residual Variation Intolerance Score:
19.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.64;
31.49% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for VPS52 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- VPS52
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VPS52 Gene
Disorders for VPS52 Gene
Additional Disease Information for VPS52
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for VPS52 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for VPS52 Gene
Publications for VPS52 Gene
- Characterization of the human GARP (Golgi associated retrograde protein) complex. (PMID: 15878329) Liewen H … Stenner-Liewen F (Experimental cell research 2005) 2 3 4 58
- Identification of a novel highly conserved gene in the centromeric part of the major histocompatibility complex. (PMID: 9790748) Walter L … Günther E (Genomics 1998) 2 3 22 58
- EARP is a multisubunit tethering complex involved in endocytic recycling. (PMID: 25799061) Schindler C … Bonifacino JS (Nature cell biology 2015) 3 4 58
- Ang2/fat-free is a conserved subunit of the Golgi-associated retrograde protein complex. (PMID: 20685960) Pérez-Victoria FJ … Bonifacino JS (Molecular biology of the cell 2010) 3 4 58
- High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PMID: 19851445) Barcellos LF … Criswell LA (PLoS genetics 2009) 3 44 58
Products for VPS52 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for VPS52
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for VPS52
- Origene Custom Protein Services for VPS52
- Origene shrna, sirna, and RNAi products in human, mouse, rat for VPS52
- Browse OriGene Inhibitory RNA Products For VPS52
- OriGene qPCR primer pairs and template standards for VPS52
- OriGene qPCR primer pairs for VPS52
- OriGene CRISPR knockouts for VPS52
- OriGene ORF clones in human for VPS52
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For VPS52
- GenScript: Next-day shipping of latest version cDNA ORF clones for VPS52 in any vector
- XM_011547273.1
- XM_011548459.1
- XM_011547270.1
- XM_011548456.1
- XM_011514798.1
- XM_011548262.1
- XM_011548074.1
- XM_011547676.1
- NM_001289176.1
- XM_011547673.1
- NM_022553.5
- XM_011547271.1
- XM_011548457.1
- XM_011514799.1
- XM_011548263.1
- XM_011548075.1
- XM_011548072.1
- XM_011547674.1
- NM_001289174.1
- XM_011547272.1
- XM_011548458.1
- XM_011514800.1
- XM_011548264.1
- XM_011514797.1
- XM_011548261.1
- XM_011548073.1
- XM_011547675.1
- NM_001289175.1
- GenScript Custom Purified and Recombinant Proteins Services for VPS52
- GenScript Custom Assay Services for VPS52
- GenScript Custom overexpressing Cell Line Services for VPS52
- GenScript: Design CRISPR guide RNA sequences for VPS52
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for VPS52
- Sino Biological Human cDNA Clone for VPS52
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse Sino Biological ELISA Kits
- Browse Sino Biological ELISA Pair Sets
- Browse Sino Biological CRO Services
- Browse Sino Biological Control Vectors
- Sino Biological Transfection Reagent
- Sino Biological Anti-His Tag Antibody
- Novus Biologicals Antibodies for VPS52
- Novus Biologicals proteins and lysates for VPS52
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Abcam proteins for VPS52
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Browse Antibodies at Cloud-Clone Corp.
- Browse Proteins at Cloud-Clone Corp.
- Browse Assay Kits at Cloud-Clone Corp.
- Browse Knockouts at Cloud-Clone Corp.
- Browse Knockins at Cloud-Clone Corp.
- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- Invitrogen Antibodies for VPS52
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Cyagen custom Knockout/knockin (KOKI) mouse models for VPS52
- VectorBuilder custom plasmid, inducible vectors for VPS52
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for VPS52
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 31 available VPS52 Antibodies ranked by validation data
- Compare Top VPS52 Antibodies
- Quality Products:
- ABIN2787317
- ABIN654879
- ABIN955527
- ABIN2745293
- ABIN4891586
- ABIN948440
- ABIN2386106
- ABIN2386103
- ABIN2386104
- ABIN2386101
- ABIN2787317
- ABIN654879
- ABIN955527
- ABIN2745293
- ABIN4891586
- ABIN948440
- ABIN2386106
- ABIN2386103
- ABIN2386104
- ABIN2386101
- ABIN2787317
- ABIN654879
- ABIN955527
- ABIN2745293
- ABIN4891586
- ABIN948440
- ABIN2386106
- ABIN2386103
- ABIN2386104
- ABIN2386101
- antibodies-online: Search results for available VPS52 related products ranked by validation data
- antibodies-online: Search results for 4 available VPS52 Proteins ranked by validation data
- Compare Top VPS52 Proteins
- Quality Products:
- GeneTex VPS52 antibody for VPS52
- Search GeneTex for Proteins for VPS52
- ViGene Biosciences adenoviral particle packaged cDNA for VPS52 gene
- ViGene Biosciences lentiviral particle packaged cDNA for VPS52 gene
- ViGene Biosciences ready-to-package AAV shRNAs for VPS52 gene
- Search ViGene Biosciences for VPS52
- Horizon Cell Lines for VPS52