Aliases for VPS52 Gene
External Ids for VPS52 Gene
Previous Symbols for VPS52 Gene
This gene encodes a protein that is similar to the yeast suppressor of actin mutations 2 gene. The yeast protein forms a subunit of the tetrameric Golgi-associated retrograde protein complex that is involved in vesicle trafficking from from both early and late endosomes, back to the trans-Golgi network. This gene is located on chromosome 6 in a head-to-head orientation with the gene encoding ribosomal protein S18. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
GeneCards Summary for VPS52 Gene
VPS52 (Vacuolar Protein Sorting 52 Homolog (S. Cerevisiae)) is a Protein Coding gene.
UniProtKB/Swiss-Prot for VPS52 Gene
May be involved in retrograde transport of early and late endosomes to the late Golgi. The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD.