Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



VPS51 Gene

protein-coding   GIFtS: 40
GCID: GC11P064864

Vacuolar Protein Sorting 51 Homolog (S. Cerevisiae)

(Previous names: chromosome 11 open reading frame 3, chromosome 11 open reading...)
(Previous symbols: C11orf3, C11orf2)
  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Vacuolar Protein Sorting 51 Homolog (S. Cerevisiae)1 2     FFR2 3
C11orf21 2 3     Chromosome 11 Open Reading Frame 21
C11orf31 2 3     Chromosome 11 Open Reading Frame 31
Another New Gene 2 Protein2 3     Fat-Free Homolog (Zebrafish)1
Protein Fat-Free Homolog2 3     ANG32
ANG22 3     Vacuolar Protein Sorting-Associated Protein 51 Homolog2

External Ids:    HGNC: 11721   Entrez Gene: 7382   Ensembl: ENSG000001498237   UniProtKB: Q9UID33   

Export aliases for VPS51 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for VPS51 Gene:
This gene encodes a member of the vacuolar protein sorting-associated protein 51 family. The encoded protein is a
component of the Golgi-associated retrograde protein complex which acts as a tethering factor for carriers in
retrograde transport from the early and late endosomes to the trans-Golgi network. Alternative splicing results
in multiple transcript variants. (provided by RefSeq, Dec 2012)

GeneCards Summary for VPS51 Gene:
VPS51 (vacuolar protein sorting 51 homolog (S. cerevisiae)) is a protein-coding gene.

UniProtKB/Swiss-Prot: VPS51_HUMAN, Q9UID3
Function: Acts as component of the GARP complex that is involved in retrograde transport from early and late
endosomes to the trans-Golgi networkl (TGN). The GARP complex is required for the maintenance of protein
retrieval from endosomes to the TGN, acid hydrolase sorting, lysosome function, endosomal cholesterol traffic and
autophagy. VPS51 participates in retrograde transport of acid hydrolase receptors, likely by promoting tethering
and SNARE-dependent fusion of endosome-derived carriers to the TGN




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NC_018922.2  NT_167190.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for VPS51
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for VPS51

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat VPS51


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13   Ensembl cytogenetic band:  11q13.1   HGNC cytogenetic band: 11q13.1

VPS51 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
VPS51 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P064864:  view genomic region     (about GC identifiers)

Start:
64,856,796 bp from pter      End:
64,879,332 bp from pter
Size:
22,537 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: VPS51_HUMAN, Q9UID3 (See protein sequence)
Recommended Name: Vacuolar protein sorting-associated protein 51 homolog  
Size: 782 amino acids; 86042 Da
Subunit: Component of the Golgi-associated retrograde protein (GARP) complex, also called VFT (VPS fifty-three)
complex, composed of VPS51, VPS52, VPS53 and VPS54. Interacts with STX6
1 PDB 3D structure from and Proteopedia for VPS51:
4J2C (3D)    
Secondary accessions: Q6PJV5 Q7L8A6 Q8WZ35 Q96DF4 Q96GR3
Alternative splicing: 2 isoforms:  Q9UID3-1   Q9UID3-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for VPS51: NX_Q9UID3

Explore proteomics data for VPS51 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys114, Lys166, Lys176, Lys189
  • Modification sites at PhosphoSitePlus

  • See VPS51 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_037397.2  
    ENSEMBL proteins: 
     ENSP00000436134   ENSP00000434138   ENSP00000279281   ENSP00000436867   ENSP00000435245  
     ENSP00000433579   ENSP00000431188   ENSP00000435691   ENSP00000434542   ENSP00000435629  
     ENSP00000431317  

    VPS51 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for VPS51
    GenScript Custom Purified and Recombinant Proteins Services for VPS51
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for VPS51 

     
    antibodies-online proteins for VPS51 

     
    antibodies-online peptides for VPS51

    VPS51 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of VPS51
    Browse R&D Systems for Antibodies
    OriGene Antibodies for VPS51
    OriGene Custom Antibody Services for VPS51
    Novus Biologicals VPS51 Antibody
    Search for Antibodies for VPS51 at Abcam
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for VPS51
    antibodies-online antibodies for VPS51 (6 products) 

    VPS51 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for VPS51
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for VPS51
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for VPS51 
    antibodies-online kits for VPS51 (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    1 InterPro protein domain:
     IPR016159 Cullin_repeat-like_dom

    Graphical View of Domain Structure for InterPro Entry Q9UID3

    ProtoNet protein and cluster: Q9UID3

    UniProtKB/Swiss-Prot: VPS51_HUMAN, Q9UID3
    Similarity: Belongs to the VPS51 family


    Find genes that share domains with VPS51           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: VPS51_HUMAN, Q9UID3
    Function: Acts as component of the GARP complex that is involved in retrograde transport from early and late
    endosomes to the trans-Golgi networkl (TGN). The GARP complex is required for the maintenance of protein
    retrieval from endosomes to the TGN, acid hydrolase sorting, lysosome function, endosomal cholesterol traffic and
    autophagy. VPS51 participates in retrograde transport of acid hydrolase receptors, likely by promoting tethering
    and SNARE-dependent fusion of endosome-derived carriers to the TGN

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0005515protein binding IPI--
         
    Find genes that share ontologies with VPS51           About GenesLikeMe


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Vps51):
     mortality/aging 

    Find genes that share phenotypes with VPS51           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for VPS51

    miRNA
    Products:
        
    miRTarBase miRNAs that target VPS51:
    hsa-mir-182-5p (MIRT047211), hsa-mir-324-5p (MIRT043055), hsa-let-7b-5p (MIRT032314)

    Block miRNA regulation of human, mouse, rat VPS51 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate VPS51
    SwitchGear 3'UTR luciferase reporter plasmidVPS51 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for VPS51
    Predesigned siRNA for gene silencing in human, mouse, rat VPS51

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for VPS51

    Clone
    Products:
         
    OriGene clones in human, mouse for VPS51 (see all 7)
    OriGene ORF clones in mouse, rat for VPS51
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for VPS51
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for VPS51
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VPS51

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for VPS51
    Browse ESI BIO Cell Lines and PureStem Progenitors for VPS51 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VPS51


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    VPS51_HUMAN, Q9UID3: Golgi apparatus, trans-Golgi network

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000775chromosome, centromeric region ----
    GO:0000938GARP complex IDA--
    GO:0005634nucleus ----
    GO:0005794Golgi apparatus IDA--
    GO:0016021integral component of membrane TAS9615229

    Find genes that share ontologies with VPS51           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for VPS51
    Interactions:

        Search GeneGlobe Interaction Network for VPS51

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    Selected Interacting proteins for VPS51 (Q9UID32, 3 ENSP000002792814) via UniProtKB, MINT, STRING, and/or I2D (see all 562)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EXOC7Q9UPT52, 3MINT-7947479 I2D: score=4 
    GSK3BP498412, 3MINT-8256965 I2D: score=2 
    NUDT3O959892, 3MINT-8264663 I2D: score=2 
    RTEL1Q9NZ713, ENSP000003533324I2D: score=5 STRING: ENSP00000353332
    CDC5LQ994592, ENSP000003605324MINT-7947479 STRING: ENSP00000360532
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006869lipid transport IEA--
    GO:0006914autophagy IMP--
    GO:0007067mitosis ----
    GO:0015031protein transport IEA--
    GO:0042147retrograde transport, endosome to Golgi IDA--

    Find genes that share ontologies with VPS51           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for VPS51



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for VPS51 gene: 
    NM_013265.3  

    Unigene Cluster for VPS51:

    Vacuolar protein sorting 51 homolog (S. cerevisiae)
    Hs.277517  [show with all ESTs]
    Unigene Representative Sequence: NR_073519
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000528588 ENST00000530773 ENST00000279281(uc001ocr.1 uc001ocs.1)
    ENST00000528050 ENST00000533656 ENST00000534124 ENST00000529180 ENST00000533487
    ENST00000526578 ENST00000534557 ENST00000527646 ENST00000531146 ENST00000533827
    ENST00000534591 ENST00000526856 ENST00000530673
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat VPS51 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate VPS51
    SwitchGear 3'UTR luciferase reporter plasmidVPS51 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for VPS51
    Predesigned siRNA for gene silencing in human, mouse, rat VPS51
    Clone
    Products:
         
    OriGene clones in human, mouse for VPS51 (see all 7)
    OriGene ORF clones in mouse, rat for VPS51
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for VPS51
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for VPS51
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VPS51
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for VPS51
    OriGene qSTAR qPCR primer pairs in human, mouse for VPS51
    Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat VPS51
      QuantiTect SYBR Green Assays in human, mouse, rat VPS51
      QuantiFast Probe-based Assays in human, mouse, rat VPS51

    Additional mRNA sequence: 

    AF024631.2 AL833818.1 BC006555.2 BC007198.1 BC009285.2 BC010540.1 BC010872.2 BC017438.1 
    NR_073519.1 

    20 DOTS entries:

    DT.91790985  DT.214891  DT.100884614  DT.95294287  DT.100712075  DT.100884629  DT.92037486  DT.101985264 
    DT.99999497  DT.100884633  DT.91758348  DT.95171817  DT.120731354  DT.75146027  DT.113060  DT.120731337 
    DT.92409892  DT.95171829  DT.99998621  DT.100884620 

    Selected AceView cDNA sequences (see all 585):

    BG742206 BM054775 BM928225 CD108198 BG684757 BG012641 BQ950165 CR594174 
    BI917307 CR595034 BQ640229 BX387263 BM910038 BX116091 BM924752 AW731818 
    AI707847 CR621135 CF529977 BI259707 CR620950 BQ030369 BQ929935 BU682796 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for VPS51 (see all 12)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c · 7d ^ 8a · 8b · 8c ^ 9a · 9b ^ 10a · 10b ^ 11a ·
    SP1:                          -                 -     -     -     -                                                                       -     -               
    SP2:                          -                 -           -     -                                                                                             
    SP3:                                            -     -     -     -                                                                                             
    SP4:                                            -           -     -                                                                                             
    SP5:                                                                                                                                      -     -               

    ExUns: 11b ^ 12a · 12b
    SP1:  -               
    SP2:                  
    SP3:                  
    SP4:                  
    SP5:                  


    ECgene alternative splicing isoforms for VPS51

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    VPS51 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    VPS51 Expression
    About this image

    VPS51 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    VPS51 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.277517
        Custom PCR Arrays for VPS51
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for VPS51
    OriGene qSTAR qPCR primer pairs in human, mouse for VPS51
    Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat VPS51
    QuantiTect SYBR Green Assays in human, mouse, rat VPS51
    QuantiFast Probe-based Assays in human, mouse, rat VPS51
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VPS51

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for VPS51 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Vps511 , 5 RIKEN cDNA 1110014N23 gene5
    vacuolar protein sorting 51 homolog (S. cerevisiae)1
    88.51(n)1
    96.07(a)1
      19 (4.34 cM)5
    685051  NM_001081041.11  NP_001074510.11 
     60678425 
    chicken
    (Gallus gallus)
    Aves VPS516
    Vacuolar protein sorting-associated protein 51 hom...
    65(a)
    1 ↔ 1
    5(1649051-1658648) ENSGALG00000004166
    lizard
    (Anolis carolinensis)
    Reptilia VPS516
    vacuolar protein sorting 51 homolog (S. cerevisiae...
    65(a)
    1 ↔ 1
    GL344221.1(25-20967)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia vps511 vacuolar protein sorting 51 homolog (S. cerevisiae) 66.8(n)
    72.13(a)
      613113  NM_001032350.1  NP_001027521.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufi30b052 wufi30b05 79.72(n)   334076  BI709958.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG150871 CG15087 52.66(n)
    44.54(a)
      37156  NM_137519.2  NP_611363.2 
    worm
    (Caenorhabditis elegans)
    Secernentea vps-511 vps-51 39.53(n)
    30.68(a)
      172247  NM_001025801.3  NP_001020972.1 


    ENSEMBL Gene Tree for VPS51 (if available)
    TreeFam Gene Tree for VPS51 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for VPS51 gene

    Find genes that share paralogs with VPS51           About GenesLikeMe


    Selected Pseudogenes.org Pseudogenes for VPS51 (see all 19)
    PGOHUM00000257795 PGOHUM00000257841 PGOHUM00000257897 PGOHUM00000257934 PGOHUM00000258026


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for VPS51 (see all 280)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1878157131,2
    --64861654(+) GGCTGA/GTCTCG 2 -- us2k10--------
    rs1124230421,2
    F--64861728(+) GCCACT/CGTGCC 2 -- us2k11Minor allele frequency- C:0.00CSA 1
    rs1420732311,2
    --64861802(+) AGTTAC/TGGAAA 2 -- us2k10--------
    rs1154090541,2
    F--64861903(+) AGACCA/GTATGA 2 -- us2k11Minor allele frequency- G:0.01WA 118
    rs1931397241,2
    --64861956(+) AAGAAA/CAAGTA 2 -- us2k10--------
    rs803557461,2
    F--64862098(+) AGATCG/ATTCCC 2 -- us2k11Minor allele frequency- A:0.01NA 120
    rs1852645431,2
    --64862209(+) GGTTGA/GAGTGA 2 -- us2k10--------
    rs5449441,2
    C,A--64862234(-) GGAGTA/GCAGTG 2 -- us2k19Minor allele frequency- G:0.48NA WA EA 370
    rs1155180391,2
    F--64862260(+) CAAAAC/TCCAGT 2 -- us2k11Minor allele frequency- T:0.01WA 118
    rs71055581,2
    C,F,A--64862263(+) aacccA/Cgtctc 2 -- us2k14Minor allele frequency- C:0.09NA CSA WA 242

    HapMap Linkage Disequilibrium report for VPS51 (64856796 - 64879332 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for VPS51: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing VPS51
    DNA2.0 Custom Variant and Variant Library Synthesis for VPS51

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for VPS51 gene, integrated from 10 sources (see all 23):
    (articles sorted by number of sources associating them with VPS51)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Ang2/fat-free is a conserved subunit of the Golgi-associated retrograde protein complex. (PubMed id 20685960)1, 2, 3 Perez-Victoria F.J.... Bonifacino J.S. (Mol. Biol. Cell 2010)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Identification and molecular characterization of TM7SF2 in the FAUNA gene cluster on human chromosome 11q13. (PubMed id 9615229)1, 2 Lemmens I.H.... Van de Ven W.J.M. (Genomics 1998)
    4. Construction of a 1.2-Mb sequence-ready contig of chromosome 11q13 encompassing the multiple endocrine neoplasia type 1 (MEN1) gene. The European Consortium on MEN1. (PubMed id 9286704)1, 3 Lemmens I....Thakker R.V. (Genomics 1997)
    5. Structural basis for the interaction of the Golgi-Associated Retrograde Protein Complex with the t-SNARE Syntaxin 6. (PubMed id 23932592)1 Abascal-Palacios G....Hierro A. (Structure 2013)
    6. Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)1 Oshikawa K....Nakayama K.I. (J. Proteome Res. 2012)
    7. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    8. Comparative large scale characterization of plant versus mammal proteins reveals similar and idiosyncratic N-I+-acetylation features. (PubMed id 22223895)2 Bienvenut W.V....Giglione C. (amp 2012)
    9. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 738 HGNC: 1172 AceView: TM7SF2andC11orf2 Ensembl:ENSG00000149823 euGenes: HUgn738
    ECgene: VPS51 H-InvDB: VPS51

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for VPS51 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for VPS51 gene:
    Search GeneIP for patents involving VPS51

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     EMD Millipore Mono- and Polyclonal Antibodies for the study of VPS51
     Browse Small Molecules at EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for VPS51   OriGene RNAi products in human, mouse, rat for VPS51  
     OriGene qPCR primer pairs and template standards for VPS51   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for VPS51  
     OriGene qSTAR qPCR primer pairs in human, mouse for VPS51   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for VPS51   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for VPS51   OriGene Custom Protein Services for VPS51  

     
     
     Block miRNA regulation of human, mouse, rat VPS51 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing VPS51
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat VPS51 Predesigned siRNA for gene silencing in human, mouse, rat VPS51
     QuantiFast Probe-based Assays in human, mouse, rat VPS51 QuantiTect SYBR Green Assays in human, mouse, rat VPS51
     Custom PCR Arrays for VPS51 Search Chromatin IP Primers for VPS51
     Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat VPS51 Search GeneGlobe Interaction Network for VPS51
     Search Regulatory tfbs for VPS51
     GenScript Custom Purified and Recombinant Proteins Services for VPS51 GenScript Custom cDNA clones with any tag delivered in your preferred vector Services for VPS51
     GenScript Custom Assay Services for VPS51 GenScript Custom overexpressing Cell Line Services for VPS51
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for VPS51
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     VPS51 antibodies
     Search for Antibodies for VPS51 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for VPS51
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for VPS51
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VPS51
     SwitchGear 3'UTR luciferase reporter plasmids for VPS51
     Browse SwitchGear Promoter luciferase reporter plasmids for VPS51
     ThermoFisher Antibodies for VPS51
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VPS51
     Browse compounds at ApexBio
     Search Addgene for plasmids for VPS51
      Search eBioscience for proteins for VPS51
      Search eBioscience for elisas for VPS51
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for VPS51
     antibodies-online antibodies for VPS51 (6 products)
     antibodies-online kits for VPS51 (4 products)
     antibodies-online peptides for VPS51
     antibodies-online proteins for VPS51
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      VPS51 gene at Home site.
    Version: 3.12.248 16 Nov 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4