VPS4B Gene
protein-coding GIFtS: 56
GCID: GC18M061056
|
|
vacuolar protein sorting 4 homolog B (S. cerevisiae)(Previous names: suppressor of K+ transport defect 1, vacuolar protein sorting...)
(Previous symbol: SKD1)
| |
Aliases
for VPS4B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Vacuolar Protein Sorting 4 Homolog B (S. Cerevisiae)1 2 | | Vacuolar Protein Sorting 4B (Yeast)1 | | SKD11 2 3 5 | | Cell Migration-Inducing 12 | | SKD1B1 2 | | Vacuolar Protein Sorting 4B2 | | VPS4-21 2 | | Vacuolar Protein Sorting-Associated Protein 4B2 | | Suppressor Of K+ Transport Defect 11 2 | | EC 3.6.4.63 | | Cell Migration-Inducing Gene 1 Protein2 3 | | VPS423 | | Suppressor Of K(+) Transport Growth Defect 12 3 | | Protein SKD13 |
Export aliases for VPS4B gene to outside databasesPrevious GC identifers: GC18M060895 GC18M061029 GC18M060841 GC18M059205 GC18M059207 GC18M057754 |
Summaries
for VPS4B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for VPS4B:
The protein encoded by this gene is a member of the AAA protein family (ATPases associated with diverse cellularactivities), and is the homolog of the yeast Vps4 protein. In humans, two paralogs of the yeast protein have beenidentified. The former share a high degree of aa sequence similarity with each other, and also with yeast Vps4 andmouse Skd1 proteins. Mouse Skd1 (suppressor of K+ transport defect 1) has been shown to be a yeast Vps4 ortholog.Functional studies indicate that both human paralogs associate with the endosomal compartments, and are involved inintracellular protein trafficking, similar to Vps4 protein in yeast. The gene encoding this paralog has been mapped tochromosome 18; the gene for the other resides on chromosome 16. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: VPS4B_HUMAN, O75351Function: Involved in late steps of the endosomal multivesicular bodies (MVB) pathway. Recognizes membrane-associatedESCRT-III assemblies and catalyzes their disassembly, possibly in combination with membrane fission. Redistributes theESCRT-III components to the cytoplasm for further rounds of MVB sorting. MVBs contain intraluminal vesicles (ILVs)that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered tolysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes andlipids. In conjunction with the ESCRT machinery also appears to function in topologically equivalent membrane fissionevents, such as the terminal stages of cytokinesis and enveloped virus budding (HIV-1 and other lentiviruses)
Gene Wiki entry for VPS4B
|
Genomic Views
for VPS4B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000018.9 NC_018929.1 NT_025028.14
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the VPS4B gene promoter:
c-Fos p53 AP-1 ATF-2 POU3F2 (N-Oct-5a) POU3F2 (N-Oct-5b) c-Jun POU3F2
Other transcription factors
Search SABiosciences Chromatin IP Primers for VPS4B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat VPS4B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 18q21.33 Ensembl cytogenetic band: 18q21.33 HGNC cytogenetic band: 18q21.33VPS4B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 18 GeneLoc Exon Structure GeneLoc location for GC18M061056: view genomic region
(about GC identifiers)
Start:
|
61,056,423 bp from pter |
End:
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61,089,752 bp from pter |
Size:
|
33,330 bases |
Orientation:
|
minus strand |
|
Proteins
for VPS4B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: VPS4B_HUMAN, O75351 (See
protein sequence)Recommended Name: Vacuolar protein sorting-associated protein 4B Size: 444 amino acids; 49302 Da
Subunit: Proposed to be monomeric or homodimeric in nucleotide-free form and to oligomerize upon binding to ATP to formtwo stacked hexameric or heptameric rings with a central pore through which ESCRT-III substrates are translocated inan ATP-dependent manner. In vitro, associates on the inside of a helical tubular structure formed by a CHMP2A-CHMP3polymer. Interacts with CHMP1A, CHMP1B, CHMP2A, CHMP4B and CHMP6. Interacts with VPS4A; the interaction suggests aheteromeric assembly with VPS4A. Interacts with VTA1
Subcellular location: Prevacuolar compartment membrane; Peripheral membrane protein. Late endosome membrane; Peripheralmembrane protein (Probable). Note=Membrane-associated in the prevacuolar endosomal compartment. Localized in HIV-1particles purified from acutely infected cells
5 PDB 3D structures from  and Proteopedia  for VPS4B:1WR0 (3D)
1XWI (3D)
2CPT (3D)
2JQH (3D)
2JQK (3D)
Secondary accessions: Q69HW4 Q9GZS7Explore the universe of human proteins at neXtProt for VPS4B: NX_O75351
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O75351
VPS4B Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_004860.2
ENSEMBL proteins: ENSP00000238497 ENSP00000465944 ENSP00000465846 Reactome Protein details: O75351
Human Recombinant Protein Products:
Gene Ontology (GO): 5/11 cellular component terms (GO ID links to tree view) (see all 11): About this table
VPS4B for ontologies About GeneDecksing
VPS4B Antibody Products:
Assay Products for VPS4B: |
Protein
Domains /
Families
for VPS4B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
VPS4B for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O75351ProtoNet protein and cluster: O75351 2 Blocks protein families: IPB003960 AAA-protein subdomain IPB007330 MIT
UniProtKB/Swiss-Prot: VPS4B_HUMAN, O75351Domain: The MIT domain serves as an adapter for ESCRT-III proteins. It forms an asymmetric three-helix bundle thatbinds amphipathic MIM (MIT interacting motif) helices along the groove between MIT helices 2 and 3 present in a subsetof ESCRT-III proteins thus establishing the canonical MIM-MIT interaction. In an extended conformation along thegroove between helices 1 and 3, also binds to a type-2 MIT interacting motif (MIM2)Similarity: Belongs to the AAA ATPase familySimilarity: Contains 1 MIT domain |
Function
for VPS4B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: VPS4B_HUMAN, O75351Function: Involved in late steps of the endosomal multivesicular bodies (MVB) pathway. Recognizes membrane-associatedESCRT-III assemblies and catalyzes their disassembly, possibly in combination with membrane fission. Redistributes theESCRT-III components to the cytoplasm for further rounds of MVB sorting. MVBs contain intraluminal vesicles (ILVs)that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered tolysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes andlipids. In conjunction with the ESCRT machinery also appears to function in topologically equivalent membrane fissionevents, such as the terminal stages of cytokinesis and enveloped virus budding (HIV-1 and other lentiviruses)Catalytic activity: ATP + H(2)O = ADP + phosphateEnzyme Number (IUBMB): EC 3.6.4.61
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for VPS4B (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for VPS4B (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: VPS4B (NM_004869) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for VPS4B | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VPS4B |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VPS4B |
Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table
VPS4B for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for VPS4B:
|
Pathways & Interactions
for VPS4B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Membrane Trafficking | | | 2 | CXCR4-mediated signaling events | | | 3 | Endocytosis | | | 4 | Signal Transduction | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1  BioSystems Pathway for VPS4B
2 
Reactome Pathways for VPS4B
1 
Kegg Pathway (Kegg details for VPS4B):
VPS4B for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for VPS4B
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/73 Interacting proteins for VPS4B (O753513 ENSP000002384974) via UniProtKB, MINT, STRING, and/or I2D (see all 73)About this table
Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12): About this table
VPS4B for ontologies About GeneDecksing
|
Drugs & Compounds
for VPS4B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
VPS4B for compounds About GeneDecksing
 Browse Tocris compounds for VPS4B
1 Novoseek chemical compound relationship for VPS4B gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| glucose |
4.72 |
2 |
2167835 (2) |
Search CenterWatch for drugs/clinical trials and news about VPS4B
|
Transcripts
for VPS4B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for VPS4B gene: NM_004869.3 Unigene Cluster for VPS4B: Vacuolar protein sorting 4 homolog B (S. cerevisiae) Hs.126550 [show with all ESTs]Unigene Representative Sequence: NM_0048697 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000238497(uc002lix.3 uc010dpx.3 uc010dpy.3 uc010dpz.1)
ENST00000588323 ENST00000588059 ENST00000591475 ENST00000589604 ENST00000591383
ENST00000591519
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for VPS4B (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for VPS4B (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: VPS4B (NM_004869) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for VPS4B | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VPS4B |
Additional cDNA sequence: AF038960.1 AF195514.1 AK290932.1 AK291253.1 AK308892.1 AK309322.1 AK311041.1 AY232629.1 BC009692.2 BC039574.1 9 DOTS entries: DT.438528 DT.100022682 DT.102831296 DT.40301457 DT.91692669 DT.95276502 DT.100747091 DT.95276501 DT.97806457 24/185 AceView cDNA sequences (see all 185): NM_004869 BX951621 CF264698 BC039574 BU189508 AA973716 CA413261 BE881718 AI306149 AA347161 AW469423 CA447088 CD656829 BQ959993 BX116546 BQ221392 BU193535 AA357927 AA281826 BG940062 Z38403 AF195514 AA653471 AI133387
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for VPS4B (see all 6) About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 |
|---|
|
| SP1: | | | | | | | | | | | - | | - | | | | | | | | | | - | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for VPS4B
|
Expression
for VPS4B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| VPS4B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See VPS4B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for VPS4B
SOURCE GeneReport for Unigene cluster: Hs.126550
UniProtKB/Swiss-Prot: VPS4B_HUMAN, O75351Tissue specificity: Ubiquitously expressed
SABiosciences Custom PCR Arrays for VPS4B
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for VPS4B
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat VPS4B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat VPS4B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat VPS4B | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VPS4B |
Orthologs
for VPS4B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for VPS4B gene from 9/38 species (see all 38) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
VPS4B1 |
vacuolar protein sorting 4 homolog B (S. cerevisiae) |
80.24(n)
90.62(a) |
|
420901 NM_001006378.2 NP_001006378.2 |
lizard
(Anolis carolinensis) |
Reptilia |
VPS4B6 |
-- |
91(a) |
1 ↔ 1 |
GL343247.1(1986740-2010927) |
African clawed frog
(Xenopus laevis) |
Amphibia |
BC042314.12 |
-- |
77.32(n) |
|
BC042314.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
zgc636822 |
similar to vacuolar protein sorting 4b (yeast) |
79.77(n) |
|
393880 BC055202.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
BcDNA:GH026783
Vps41 |
intracellular protein transport
adenosinetriphosphatase3
Vacuolar protein sorting 41 |
74(a)
(best of 3)3
65.59(n)1
76.5(a)1 |
|
327771 NM_133030.31 NP_573258.11 |
worm
(Caenorhabditis elegans) |
Secernentea |
Y34D9A.103
vps-41 |
Protein VPS-41 |
53(a)
(best of 3)3
62.9(n)1
70.82(a)1 |
|
I(1065980-1066871)3
1895901 NM_058415.41 NP_490816.41 |
baker's yeast
(Saccharomyces cerevisiae) |
Saccharomycetes |
VPS4(YPR173C)4
VPS41 |
AAA-ATPase involved in multivesicular body (MVB) protein more4
Vps4p1 |
59.66(n)1
63.55(a)1 |
|
16(887837-886524)4
8563031, 4 NP_015499.11, 4 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
SKD11 |
vacuolar protein-sorting-associated protein 4 |
58.97(n)
57.86(a) |
|
817306 NM_128319.3 NP_180328.1 |
rice
(Oryza sativa) |
Liliopsida |
Os.73852 |
Oryza sativa (japonica cultivar-group) AAA-ATPase-like more |
72.3(n) |
|
AF499028.1 |
ENSEMBL Gene Tree for VPS4B (if available)
TreeFam Gene Tree for VPS4B (if available) |
Paralogs
for VPS4B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for VPS4B gene
- ENSG000002609142 KATNAL12 VPS4A2 KATNA12 KATNAL22
9 SIMAP similar genes for VPS4B using alignment to 4 protein entries: VPS4B_HUMAN (see all proteins):DKFZp434E0418 VPS4A ULK3 KATNAL2 ATAD1 FIGNL1
KATNAL1 KATNA1 MITD1
VPS4B for paralogs About GeneDecksing
|
Genomic Variants
for VPS4B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 18 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for VPS4B (61056423 - 61089752 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for VPS4B: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing VPS4B |
|
Disorders
/ Diseases
for VPS4B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
VPS4B for disorders About GeneDecksing
OMIM gene information: 609983
OMIM disorders: --
11  diseases for VPS4B: About MalaCardshepatitis e nephroblastoma stomatitis nephropathy
hepatitis b conjunctivitis hepatocellular carcinoma hepatitis
influenza cholesterol carcinoma
Human Genome Epidemiology (HuGE) Navigator: VPS4B (2 documents)
Export disorders for VPS4B gene to outside databases
|
Publications
for VPS4B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for VPS4B gene, integrated from 9 sources (see all 61):
(articles sorted by number of sources associating them with VPS4B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Mammalian cells express two VPS4 proteins both of which are involved in intracellular protein trafficking. (PubMed id 11563910)1, 2, 3, 9 Scheuring S.... Koehrer K. (2001)
- Comparative sequence and expression analyses of four mammalian VPS4 genes. (PubMed id 12594041)1, 2, 9 Beyer A....Koehrer K. (2003)
- Biochemical analyses of human IST1 and its function in cytokinesis. (PubMed id 19129479)1, 2 Bajorek M....Sundquist W.I. (2009)
- ESCRT-III recognition by VPS4 ATPases. (PubMed id 17928862)1, 2 Stuchell-Brereton M.D.... Sundquist W.I. (2007)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
- Structural characterization of the MIT domain from human Vps4b. (PubMed id 16018968)1, 2 Takasu H.... Hiroaki H. (2005)
- Structural and mechanistic studies of VPS4 proteins. (PubMed id 16193069)1, 2 Scott A....Sundquist W.I. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The protein network of HIV budding. (PubMed id 14505570)1, 2 von Schwedler U.K.... Sundquist W.I. (2003)
- CHMP1 functions as a member of a newly defined family of vesicle trafficking proteins. (PubMed id 11559748)1, 2 Howard T.L....Hollenberg S.M. (2001)
|
External Searches for VPS4B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing VPS4B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
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Other Databases showing VPS4B gene
(According to HUGE)
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Specialized Databases showing VPS4B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Name | Description |
| PharmGKB entry for VPS4B | Pharmacogenomics, SNPs, Pathways |
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| Patent Information for VPS4B gene:
Search GeneIP for patents involving VPS4B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for VPS4B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for VPS4B | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for VPS4B | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for VPS4B | | | OriGene Protein Over-expression Lysate for VPS4B | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for VPS4B | | OriGene 3'-UTR Clone for VPS4B | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for VPS4B | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for VPS4B | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for VPS4B | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for VPS4B | | OriGene Custom Protein Services for VPS4B | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat VPS4B | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing VPS4B | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat VPS4B | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat VPS4B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat VPS4B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat VPS4B |
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| | | | Search Tocris compounds for VPS4B |
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 | | | VPS4B Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VPS4B |
|  |  |  | | | | Search ThermoFisher Antibodies for VPS4B |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VPS4B |
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