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VPS4B Gene

protein-coding   GIFtS: 62
GCID: GC18M061056

Vacuolar Protein Sorting 4 Homolog B (S. Cerevisiae)

(Previous names: suppressor of K+ transport defect 1, vacuolar protein sorting...)
(Previous symbol: SKD1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Vacuolar Protein Sorting 4 Homolog B (S. Cerevisiae)1 2     VPS4-22
SKD11 2 3 5     Cell Migration-Inducing 12
Suppressor Of K+ Transport Defect 11 2     Vacuolar Protein Sorting 4B2
Cell Migration-Inducing Gene 1 Protein2 3     Vacuolar Protein Sorting-Associated Protein 4B2
Suppressor Of K(+) Transport Growth Defect 12 3     EC 3.6.4.63
Vacuolar Protein Sorting 4B (Yeast)1     VPS423
SKD1B2     Protein SKD13

External Ids:    HGNC: 108951   Entrez Gene: 95252   Ensembl: ENSG000001195417   OMIM: 6099835   UniProtKB: O753513   

Export aliases for VPS4B gene to outside databases

Previous GC identifers: GC18M060895 GC18M061029 GC18M060841 GC18M059205 GC18M059207 GC18M057754


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for VPS4B Gene:
The protein encoded by this gene is a member of the AAA protein family (ATPases associated with diverse cellular
activities), and is the homolog of the yeast Vps4 protein. In humans, two paralogs of the yeast protein have been
identified. The former share a high degree of aa sequence similarity with each other, and also with yeast Vps4
and mouse Skd1 proteins. Mouse Skd1 (suppressor of K+ transport defect 1) has been shown to be a yeast Vps4
ortholog. Functional studies indicate that both human paralogs associate with the endosomal compartments, and are
involved in intracellular protein trafficking, similar to Vps4 protein in yeast. The gene encoding this paralog
has been mapped to chromosome 18; the gene for the other resides on chromosome 16. (provided by RefSeq, Jul 2008)

GeneCards Summary for VPS4B Gene:
VPS4B (vacuolar protein sorting 4 homolog B (S. cerevisiae)) is a protein-coding gene. Diseases associated with VPS4B include nephroblastoma, and hepatitis e. GO annotations related to this gene include ATPase activity, coupled and protein C-terminus binding. An important paralog of this gene is ENSG00000260914.

UniProtKB/Swiss-Prot: VPS4B_HUMAN, O75351
Function: Involved in late steps of the endosomal multivesicular bodies (MVB) pathway. Recognizes
membrane-associated ESCRT-III assemblies and catalyzes their disassembly, possibly in combination with membrane
fission. Redistributes the ESCRT-III components to the cytoplasm for further rounds of MVB sorting. MVBs contain
intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the
endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated
growth factor receptors, lysosomal enzymes and lipids. In conjunction with the ESCRT machinery also appears to
function in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and
enveloped virus budding (HIV-1 and other lentiviruses)

Gene Wiki entry for VPS4B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000018.10  NT_010966.15  NC_018929.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the VPS4B gene promoter:
         c-Fos   p53   AP-1   ATF-2   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   c-Jun   POU3F2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidVPS4B promoter sequence
   Search Chromatin IP Primers for VPS4B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat VPS4B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q21.33   Ensembl cytogenetic band:  18q21.33   HGNC cytogenetic band: 18q21.33

VPS4B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
VPS4B gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18M061056:  view genomic region     (about GC identifiers)

Start:
61,056,423 bp from pter      End:
61,089,752 bp from pter
Size:
33,330 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: VPS4B_HUMAN, O75351 (See protein sequence)
Recommended Name: Vacuolar protein sorting-associated protein 4B  
Size: 444 amino acids; 49302 Da
Subunit: Proposed to be monomeric or homodimeric in nucleotide-free form and to oligomerize upon binding to ATP to
form two stacked hexameric or heptameric rings with a central pore through which ESCRT-III substrates are
translocated in an ATP-dependent manner. In vitro, associates on the inside of a helical tubular structure formed
by a CHMP2A-CHMP3 polymer. Interacts with CHMP1A, CHMP1B, CHMP2A, CHMP4B and CHMP6. Interacts with VPS4A; the
interaction suggests a heteromeric assembly with VPS4A. Interacts with VTA1
5 PDB 3D structures from and Proteopedia for VPS4B:
1WR0 (3D)        1XWI (3D)        2CPT (3D)        2JQH (3D)        2JQK (3D)    
Secondary accessions: Q69HW4 Q9GZS7

Explore the universe of human proteins at neXtProt for VPS4B: NX_O75351

Explore proteomics data for VPS4B at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys147, Lys155, Lys163, Lys217
  • Modification sites at PhosphoSitePlus

  • See VPS4B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004860.2  
    ENSEMBL proteins: 
     ENSP00000238497   ENSP00000465944   ENSP00000465846  
    Reactome Protein details: O75351

    VPS4B Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    AATP: ATPases / AAA-type

    Selected InterPro protein domains (see all 6):
     IPR003959 ATPase_AAA_core
     IPR015415 Vps4_C
     IPR003960 ATPase_AAA_CS
     IPR027417 P-loop_NTPase
     IPR003593 AAA+_ATPase

    Graphical View of Domain Structure for InterPro Entry O75351

    ProtoNet protein and cluster: O75351

    2 Blocks protein domains:
    IPB003960 AAA-protein subdomain
    IPB007330 MIT


    UniProtKB/Swiss-Prot: VPS4B_HUMAN, O75351
    Domain: The MIT domain serves as an adapter for ESCRT-III proteins. It forms an asymmetric three-helix bundle that
    binds amphipathic MIM (MIT interacting motif) helices along the groove between MIT helices 2 and 3 present in a
    subset of ESCRT-III proteins thus establishing the canonical MIM-MIT interaction. In an extended conformation
    along the groove between helices 1 and 3, also binds to a type-2 MIT interacting motif (MIM2)
    Similarity: Belongs to the AAA ATPase family
    Similarity: Contains 1 MIT domain


    VPS4B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: VPS4B_HUMAN, O75351
    Function: Involved in late steps of the endosomal multivesicular bodies (MVB) pathway. Recognizes
    membrane-associated ESCRT-III assemblies and catalyzes their disassembly, possibly in combination with membrane
    fission. Redistributes the ESCRT-III components to the cytoplasm for further rounds of MVB sorting. MVBs contain
    intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the
    endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated
    growth factor receptors, lysosomal enzymes and lipids. In conjunction with the ESCRT machinery also appears to
    function in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and
    enveloped virus budding (HIV-1 and other lentiviruses)
    Catalytic activity: ATP + H(2)O = ADP + phosphate

         Enzyme Number (IUBMB): EC 3.6.4.61

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding ----
    GO:0005515protein binding IPI11563910
    GO:0005524ATP binding IMP10637304
    GO:0008022protein C-terminus binding IPI17928862
    GO:0009378four-way junction helicase activity ----
         
    VPS4B for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for VPS4B:
     Cell cycle / mitosis defect  Upregulation of Wnt/beta-caten 

    Animal Models:
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    miRNA
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    hsa-mir-19b-3p (MIRT031206), hsa-mir-128-3p (MIRT022010), hsa-mir-155-5p (MIRT020843), hsa-mir-124-3p (MIRT022778), hsa-mir-19a-3p (MIRT031307), hsa-mir-32-5p (MIRT028319)

    Block miRNA regulation of human, mouse, rat VPS4B using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate VPS4B (see all 26):
    hsa-miR-125a-5p hsa-miR-25 hsa-miR-128 hsa-miR-16-1* hsa-let-7a-2* hsa-miR-624 hsa-miR-488 hsa-miR-511
    SwitchGear 3'UTR luciferase reporter plasmidVPS4B 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for VPS4B
    Predesigned siRNA for gene silencing in human, mouse, rat VPS4B

    Gene Editing
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VPS4B


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    VPS4B_HUMAN, O75351: Prevacuolar compartment membrane; Peripheral membrane protein. Late endosome membrane;
    Peripheral membrane protein (Probable). Note=Membrane-associated in the prevacuolar endosomal compartment.
    Localized in HIV-1 particles purified from acutely infected cells
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    endosome5
    lysosome5
    nucleus5
    vacuole5
    plasma membrane1

    Gene Ontology (GO): Selected cellular component terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA16757520
    GO:0005737cytoplasm IDA16757520
    GO:0005764lysosome IDA10637304
    GO:0005768endosome IDA11563910
    GO:0005769early endosome IDA10637304

    VPS4B for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for VPS4B About   (see all 6)                                                                                              See pathways by source

    SuperPathContained pathways About
    1HIV Life Cycle
    HIV Life Cycle0.91
    HIV Infection0.62
    Late Phase of HIV Life Cycle0.91
    2Budding and maturation of HIV virion
    Budding and maturation of HIV virion0.64
    Endosomal Sorting Complex Required For Transport (ESCRT)0.64
    3Clathrin derived vesicle budding
    Membrane Trafficking0.32
    4Endocytosis
    Endocytosis
    5Disease
    Disease

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for VPS4B
        CXCR4-mediated signaling events

    2 Reactome Pathways for VPS4B
        Budding and maturation of HIV virion
    Endosomal Sorting Complex Required For Transport (ESCRT)


    1 Kegg Pathway  (Kegg details for VPS4B):
        Endocytosis


    VPS4B for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for VPS4B
    Interactions:

        GeneGlobe Interaction Network for VPS4B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for VPS4B (O753513 ENSP000002384974) via UniProtKB, MINT, STRING, and/or I2D (see all 161)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CHMP4AQ9BY433, ENSP000003242054I2D: score=8 STRING: ENSP00000324205
    PDCD6IPQ8WUM43, ENSP000003073874I2D: score=6 STRING: ENSP00000307387
    CHMP2AO436333, ENSP000003104404I2D: score=4 STRING: ENSP00000310440
    CHMP1AQ9HD423, ENSP000002534754I2D: score=3 STRING: ENSP00000253475
    BABAM1Q9NWV83, ENSP000003524084I2D: score=2 STRING: ENSP00000352408
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006200ATP catabolic process IMP10637304
    GO:0006281DNA repair ----
    GO:0006310DNA recombination ----
    GO:0006813potassium ion transport IEA--
    GO:0007032endosome organization IEA--

    VPS4B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for VPS4B

    1 Novoseek inferred chemical compound relationship for VPS4B gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glucose 4.72 2 2167835 (2)



    VPS4B for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for VPS4B gene: 
    NM_004869.3  

    Unigene Cluster for VPS4B:

    Vacuolar protein sorting 4 homolog B (S. cerevisiae)
    Hs.126550  [show with all ESTs]
    Unigene Representative Sequence: NM_004869
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000238497(uc002lix.3 uc010dpx.3 uc010dpy.3 uc010dpz.1)
    ENST00000588323 ENST00000588059 ENST00000591475 ENST00000589604 ENST00000591383
    ENST00000591519
    miRNA
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    hsa-miR-125a-5p hsa-miR-25 hsa-miR-128 hsa-miR-16-1* hsa-let-7a-2* hsa-miR-624 hsa-miR-488 hsa-miR-511
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      QuantiTect SYBR Green Assays in human, mouse, rat VPS4B
      QuantiFast Probe-based Assays in human, mouse, rat VPS4B

    Additional mRNA sequence: 

    AF038960.1 AF195514.1 AK290932.1 AK291253.1 AK308892.1 AK309322.1 AK311041.1 AY232629.1 
    BC009692.2 BC039574.1 

    9 DOTS entries:

    DT.438528  DT.100022682  DT.102831296  DT.40301457  DT.91692669  DT.95276502  DT.100747091  DT.95276501 
    DT.97806457 

    Selected AceView cDNA sequences (see all 185):

    Z38403 AA877189 AI306149 BM455084 BQ024689 BM052903 BC039574 AA357927 
    AA347161 CA447088 BU193535 AI133387 BU159341 BQ959993 AF195514 BX116546 
    BG940062 AY232629 AA653471 BU189508 BU178404 AI765982 BE881718 AA973716 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for VPS4B (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
    SP1:                                -     -                             -                     
    SP2:                                                                                          
    SP3:                                                                                          
    SP4:                                                                                          
    SP5:                                -     -                                                   


    ECgene alternative splicing isoforms for VPS4B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    VPS4B expression in normal human tissues (normalized intensities)      VPS4B embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    VPS4B Expression
    About this image


    VPS4B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Epithelial Cells
             Presumptive Podocytes Podocyte Layer
     
     Kidney (Urinary System)
             Presumptive Podocytes Podocyte Layer
     
     Colon (Gastrointestinal Tract)
     
     Esophagus (Gastrointestinal Tract)
    VPS4B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    VPS4B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.126550

    UniProtKB/Swiss-Prot: VPS4B_HUMAN, O75351
    Tissue specificity: Ubiquitously expressed

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VPS4B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for VPS4B gene from Selected species (see all 26)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Vps4b1 , 5 vacuolar protein sorting 4b (yeast)1, 5 88.44(n)1
    95.5(a)1
      1 (50.10 cM)5
    204791  NM_009190.21  NP_033216.21 
     1067640715 
    chicken
    (Gallus gallus)
    Aves VPS4B1 vacuolar protein sorting 4 homolog B (S. cerevisiae) 80.24(n)
    90.62(a)
      420901  NM_001006378.2  NP_001006378.2 
    lizard
    (Anolis carolinensis)
    Reptilia VPS4B6
    vacuolar protein sorting 4 homolog B (S. cerevisia...
    90(a)
    1 ↔ 1
    GL343247.1(1986740-2010927)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC042314.12   -- 77.32(n)    BC042314.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc636822 similar to vacuolar protein sorting 4b (yeast) 79.77(n)   393880  BC055202.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta BcDNA:GH026783 intracellular protein transport
    adenosinetriphosphatase
    74(a)
    (best of 3)
        --
    worm
    (Caenorhabditis elegans)
    Secernentea Y34D9A.103
    vps-41
    vps-41 53(a)
    (best of 3)3
    62.9(n)1
    70.82(a)1
      I(1065980-1066871)3
    1895901  NM_058415.51  NP_490816.41 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes VPS4(YPR173C)4
    VPS41
    AAA-ATPase involved in multivesicular body (MVB) protein more4
    VPS41
    59.74(n)1
    63.32(a)1
      16(887837-886524)4
    8563031, 4  NP_015499.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons SKD11 SKD1 58.97(n)
    57.86(a)
      817306  NM_128319.3  NP_180328.1 
    rice
    (Oryza sativa)
    Liliopsida Os.73852 Oryza sativa (japonica cultivar-group) AAA-ATPase-like more 72.3(n)    AF499028.1 


    ENSEMBL Gene Tree for VPS4B (if available)
    TreeFam Gene Tree for VPS4B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for VPS4B gene
    ENSG000002609142  KATNAL12  KATNAL22  VPS4A2  KATNA12  
    10 SIMAP similar genes for VPS4B using alignment to 4 protein entries:     VPS4B_HUMAN (see all proteins):
    DKFZp434E0418    VPS4A    ULK3    SPAST    KATNAL2    ATAD1
    FIGNL1    KATNAL1    MITD1    KATNA1

    VPS4B for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for VPS4B (see all 754)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 18 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1881768811,2
    --61055989(+) GTGGCC/TAAATG 1 -- ds50010--------
    rs1490136791,2
    --61056015(+) TAATCA/GAGTAC 1 -- ds50010--------
    rs1810223991,2
    --61056050(+) GTTGAA/CAGTGG 1 -- ds50010--------
    rs1846763421,2
    --61056078(+) CTATTA/GACATG 1 -- ds50010--------
    rs1907759621,2
    --61056083(+) GACATA/GTTTTA 1 -- ds50010--------
    rs1816486371,2
    --61056221(+) TATAAC/TTACTG 1 -- ds50010--------
    rs1870527971,2
    --61056227(+) TACTGC/GTCAAG 1 -- ds50010--------
    rs1910173581,2
    --61056261(+) ATTCGA/GATTCC 1 -- ds50010--------
    rs1813775281,2
    --61056410(+) AGTCAC/TTGAAA 1 -- ds50010--------
    rs1480976961,2
    --61056421(+) AACAGA/GATTTT 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for VPS4B (61056423 - 61089752 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for VPS4B: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing VPS4B
    DNA2.0 Custom Variant and Variant Library Synthesis for VPS4B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609983    OMIM disorders: --

    11 diseases for VPS4B:    About MalaCards
    nephroblastoma    hepatitis e    conjunctivitis    diabetic nephropathy
    influenza    hiv-1    hypoxia    hepatitis
    hepatitis b    hepatocellular carcinoma    malaria


    VPS4B for disorders           About GeneDecksing

    Genetic Association Database (GAD): VPS4B
    Human Genome Epidemiology (HuGE) Navigator: VPS4B (2 documents)

    Export disorders for VPS4B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for VPS4B gene, integrated from 10 sources (see all 67):
    (articles sorted by number of sources associating them with VPS4B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Mammalian cells express two VPS4 proteins both of which are involved in intracellular protein trafficking. (PubMed id 11563910)1, 2, 3, 9 Scheuring S.... Koehrer K. (J. Mol. Biol. 2001)
    2. Comparative sequence and expression analyses of four mammalian VPS4 genes. (PubMed id 12594041)1, 2, 9 Beyer A....Koehrer K. (Gene 2003)
    3. Biochemical analyses of human IST1 and its function in cytokinesis. (PubMed id 19129479)1, 2 Bajorek M....Sundquist W.I. (Mol. Biol. Cell 2009)
    4. Genetic analysis of diabetic nephropathy on chromosome 18 in African Americans: linkage analysis and dense SNP mapping. (PubMed id 19690890)1, 4 McDonough C.W....Bowden D.W. (Hum. Genet. 2009)
    5. ESCRT-III recognition by VPS4 ATPases. (PubMed id 17928862)1, 2 Stuchell-Brereton M.D.... Sundquist W.I. (Nature 2007)
    6. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    7. Structural characterization of the MIT domain from human Vps4b. (PubMed id 16018968)1, 2 Takasu H.... Hiroaki H. (Biochem. Biophys. Res. Commun. 2005)
    8. Structural and mechanistic studies of VPS4 proteins. (PubMed id 16193069)1, 2 Scott A....Sundquist W.I. (EMBO J. 2005)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. The protein network of HIV budding. (PubMed id 14505570)1, 2 von Schwedler U.K.... Sundquist W.I. (Cell 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9525 HGNC: 10895 AceView: VPS4B Ensembl:ENSG00000119541 euGenes: HUgn9525
    ECgene: VPS4B Kegg: 9525 H-InvDB: VPS4B

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for VPS4B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for VPS4B gene:
    Search GeneIP for patents involving VPS4B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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