Free for academic non-profit institutions. Other users need a Commercial license

Aliases for VPS4A Gene

Aliases for VPS4A Gene

  • Vacuolar Protein Sorting 4 Homolog A (S. Cerevisiae) 2 3
  • VPS4 3 4 6
  • VPS4-1 3 4
  • HVPS4 3 4
  • Vacuolar Protein Sorting-Associated Protein 4A 3
  • Vacuolar Protein Sorting 4A (Yeast Homolog) 2
  • Vacuolar Protein Sorting 4A (Yeast) 2
  • Vacuolar Protein Sorting Factor 4A 3
  • Vacuolar Sorting Protein 4 3
  • SKD1-Homolog 3
  • Protein SKD2 4
  • EC 3.6.4.6 4
  • SKD1A 3
  • SKD2 3
  • SKD1 3

External Ids for VPS4A Gene

Summaries for VPS4A Gene

Entrez Gene Summary for VPS4A Gene

  • The protein encoded by this gene is a member of the AAA protein family (ATPases associated with diverse cellular activities), and is the homolog of the yeast Vps4 protein. In humans, two paralogs of the yeast protein have been identified. The former share a high degree of aa sequence similarity with each other, and also with yeast Vps4 and mouse Skd1 proteins. The mouse Skd1 (suppressor of K+ transport defect 1) has been shown to be really an yeast Vps4 ortholog. Functional studies indicate that both human paralogs associate with the endosomal compartments, and are involved in intracellular protein trafficking, similar to Vps4 protein in yeast. The gene encoding this paralog has been mapped to chromosome 16; the gene for the other resides on chromosome 18. [provided by RefSeq, Jul 2008]

GeneCards Summary for VPS4A Gene

VPS4A (Vacuolar Protein Sorting 4 Homolog A (S. Cerevisiae)) is a Protein Coding gene. Among its related pathways are Disease and Endocytosis. GO annotations related to this gene include protein C-terminus binding and ATPase activity, coupled. An important paralog of this gene is KATNA1.

UniProtKB/Swiss-Prot for VPS4A Gene

  • Involved in late steps of the endosomal multivesicular bodies (MVB) pathway. Recognizes membrane-associated ESCRT-III assemblies and catalyzes their disassembly, possibly in combination with membrane fission. Redistributes the ESCRT-III components to the cytoplasm for further rounds of MVB sorting. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. In conjunction with the ESCRT machinery also appears to function in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and enveloped virus budding (HIV-1 and other lentiviruses). Involved in cytokinesis: retained at the midbody by ZFYVE19/ANCHR and CHMP4C until abscission checkpoint signaling is terminated at late cytokinesis. It is then released following dephosphorylation of CHMP4C, leading to abscission (PubMed:24814515).

Gene Wiki entry for VPS4A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VPS4A Gene

Genomics for VPS4A Gene

Genomic Location for VPS4A Gene

Start:
69,311,356 bp from pter
End:
69,326,939 bp from pter
Size:
15,584 bases
Orientation:
Plus strand

Genomic View for VPS4A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for VPS4A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VPS4A Gene

Regulatory Elements for VPS4A Gene

Proteins for VPS4A Gene

  • Protein details for VPS4A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UN37-VPS4A_HUMAN
    Recommended name:
    Vacuolar protein sorting-associated protein 4A
    Protein Accession:
    Q9UN37
    Secondary Accessions:
    • B2RCB7
    • Q8TF07
    • Q9UI03
    • Q9Y582

    Protein attributes for VPS4A Gene

    Size:
    437 amino acids
    Molecular mass:
    48898 Da
    Quaternary structure:
    • Proposed to be monomeric or homodimeric in nucleotide-free form and to oligomerize upon binding to ATP to form two stacked hexameric or heptameric rings with a central pore through which ESCRT-III substrates are translocated in an ATP-dependent manner (By similarity). Interacts with CHMP1A, CHMP1B, CHMP2A, CHMP2B, CHMP3, CHMP4A, CHMP4B, CHMP4C and CHMP6. Interacts with VPS4B; the interaction suggests a heteromeric assembly with VPS4B. Interacts with SPAST. Interacts with IST1. Interacts with ZFYVE19/ANCHR; leading to retain it at midbody.
    SequenceCaution:
    • Sequence=AAL75948.1; Type=Frameshift; Positions=123, 133, 157, 163; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for VPS4A Gene

neXtProt entry for VPS4A Gene

Proteomics data for VPS4A Gene at MOPED

Post-translational modifications for VPS4A Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys140, Lys148, Lys156, and Lys210

Other Protein References for VPS4A Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for VPS4A Gene

Domains for VPS4A Gene

Gene Families for VPS4A Gene

HGNC:
  • AATP :ATPases / AAA-type

Protein Domains for VPS4A Gene

UniProtKB/Swiss-Prot:

VPS4A_HUMAN
Domain:
  • The MIT domain serves as an adapter for ESCRT-III proteins. It forms an asymmetric three-helix bundle that binds amphipathic MIM (MIT interacting motif) helices along the groove between MIT helices 2 and 3 present in a subset of ESCRT-III proteins thus establishing the canonical MIM-MIT interaction. In an extended conformation along the groove between helices 1 and 3, also binds to a type-2 MIT interacting motif (MIM2):
    • Q9UN37
  • Contains 1 MIT domain.:
    • Q9UN37
Family:
  • Belongs to the AAA ATPase family.:
    • Q9UN37
genes like me logo Genes that share domains with VPS4A: view

Function for VPS4A Gene

Molecular function for VPS4A Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + H(2)O = ADP + phosphate
UniProtKB/Swiss-Prot Function: Involved in late steps of the endosomal multivesicular bodies (MVB) pathway. Recognizes membrane-associated ESCRT-III assemblies and catalyzes their disassembly, possibly in combination with membrane fission. Redistributes the ESCRT-III components to the cytoplasm for further rounds of MVB sorting. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. In conjunction with the ESCRT machinery also appears to function in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and enveloped virus budding (HIV-1 and other lentiviruses). Involved in cytokinesis: retained at the midbody by ZFYVE19/ANCHR and CHMP4C until abscission checkpoint signaling is terminated at late cytokinesis. It is then released following dephosphorylation of CHMP4C, leading to abscission (PubMed:24814515).

Enzyme Numbers (IUBMB) for VPS4A Gene

Gene Ontology (GO) - Molecular Function for VPS4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 11559748
GO:0005524 ATP binding IMP 10637304
GO:0008022 protein C-terminus binding IPI 17928862
GO:0008568 NOT microtubule-severing ATPase activity IBA --
GO:0009378 four-way junction helicase activity --
genes like me logo Genes that share ontologies with VPS4A: view
genes like me logo Genes that share phenotypes with VPS4A: view

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for VPS4A Gene

Localization for VPS4A Gene

Subcellular locations from UniProtKB/Swiss-Prot for VPS4A Gene

Prevacuolar compartment membrane; Peripheral membrane protein. Late endosome membrane; Peripheral membrane protein. Midbody. Note=Membrane-associated in the prevacuolar endosomal compartment. Localizes to the midbody of dividing cells, interaction with ZFYVE19/ANCHR mediates retention at midbody (PubMed:24814515). Localized in two distinct rings on either side of the Fleming body. {ECO:0000269 PubMed:24814515}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for VPS4A Gene COMPARTMENTS Subcellular localization image for VPS4A gene
Compartment Confidence
endosome 5
cytosol 4
plasma membrane 2
vacuole 2
cytoskeleton 1
extracellular 1
lysosome 1
nucleus 1

Gene Ontology (GO) - Cellular Components for VPS4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000815 colocalizes_with ESCRT III complex IDA 18606141
GO:0000922 spindle pole IDA 20616062
GO:0005634 nucleus IDA 20616062
GO:0005737 cytoplasm IDA 11563910
GO:0005764 lysosome IDA 10637304
genes like me logo Genes that share ontologies with VPS4A: view

Pathways for VPS4A Gene

genes like me logo Genes that share pathways with VPS4A: view

Pathways by source for VPS4A Gene

1 BioSystems pathway for VPS4A Gene
1 KEGG pathway for VPS4A Gene

Gene Ontology (GO) - Biological Process for VPS4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000910 cytokinesis --
GO:0000920 cell separation after cytokinesis IMP 20616062
GO:0006200 obsolete ATP catabolic process --
GO:0006281 DNA repair --
GO:0006310 DNA recombination --
genes like me logo Genes that share ontologies with VPS4A: view

Compounds for VPS4A Gene

(1) Novoseek inferred chemical compound relationships for VPS4A Gene

Compound -log(P) Hits PubMed IDs
atp 19.3 3
genes like me logo Genes that share compounds with VPS4A: view

Transcripts for VPS4A Gene

mRNA/cDNA for VPS4A Gene

Unigene Clusters for VPS4A Gene

Vacuolar protein sorting 4 homolog A (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for VPS4A Gene

No ASD Table

Relevant External Links for VPS4A Gene

GeneLoc Exon Structure for
VPS4A
ECgene alternative splicing isoforms for
VPS4A

Expression for VPS4A Gene

mRNA expression in normal human tissues for VPS4A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for VPS4A Gene

SOURCE GeneReport for Unigene cluster for VPS4A Gene Hs.128420

mRNA Expression by UniProt/SwissProt for VPS4A Gene

Q9UN37-VPS4A_HUMAN
Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expressions with VPS4A: view

Orthologs for VPS4A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for VPS4A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia VPS4A 36
  • 99.46 (n)
  • 99.77 (a)
VPS4A 37
  • 100 (a)
OneToMany
cow
(Bos Taurus)
Mammalia VPS4A 37
  • 97 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 37
  • 98 (a)
OneToMany
VPS4A 36
  • 92.14 (n)
  • 98.86 (a)
mouse
(Mus musculus)
Mammalia Vps4a 36
  • 89.09 (n)
  • 99.08 (a)
Vps4a 16
Vps4a 37
  • 99 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 91 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 91 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Vps4a 36
  • 88.94 (n)
  • 99.08 (a)
chicken
(Gallus gallus)
Aves -- 37
  • 90 (a)
OneToMany
VPS4A 36
  • 83.57 (n)
  • 91.4 (a)
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 92 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia vps4a 36
  • 77.78 (n)
  • 92.41 (a)
zebrafish
(Danio rerio)
Actinopterygii vps4a 36
  • 80.23 (n)
  • 90.07 (a)
vps4a 37
  • 80 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000625 36
  • 70.06 (n)
  • 77.55 (a)
fruit fly
(Drosophila melanogaster)
Insecta Vps4 36
  • 71.32 (n)
  • 76.74 (a)
Vps4 37
  • 74 (a)
OneToMany
CG10793 38
  • 37 (a)
BG:DS06874.3 38
  • 40 (a)
BcDNA:GH02678 38
  • 72 (a)
worm
(Caenorhabditis elegans)
Secernentea vps-4 37
  • 68 (a)
OneToMany
K04D7.2b 38
  • 38 (a)
Y34D9A.10 38
  • 57 (a)
K04D7.2a 38
  • 38 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes VPS4 37
  • 59 (a)
OneToMany
barley
(Hordeum vulgare)
Liliopsida Hv.6235 36
wheat
(Triticum aestivum)
Liliopsida Ta.1709 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10007 37
  • 70 (a)
OneToMany
Species with no ortholog for VPS4A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for VPS4A Gene

ENSEMBL:
Gene Tree for VPS4A (if available)
TreeFam:
Gene Tree for VPS4A (if available)

Paralogs for VPS4A Gene

Paralogs for VPS4A Gene

Selected SIMAP similar genes for VPS4A Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with VPS4A: view

Variants for VPS4A Gene

Sequence variations from dbSNP and Humsavar for VPS4A Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs12258 -- 69,325,013(-) TTAGA(C/T)CATTT utr-variant-3-prime
rs153050 -- 69,315,835(-) CAAAG(A/G)AGGCT intron-variant
rs827049 -- 69,318,364(-) AATGT(C/G)CTTCA intron-variant
rs862348 -- 69,317,575(-) acctc(A/G)tgatc intron-variant
rs863769 -- 69,317,642(-) ctaat(A/T)ttttg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for VPS4A Gene

Variant ID Type Subtype PubMed ID
nsv906820 CNV Loss 21882294
nsv827715 CNV Loss 20364138
nsv523736 CNV Loss 19592680

Relevant External Links for VPS4A Gene

HapMap Linkage Disequilibrium report
VPS4A
Human Gene Mutation Database (HGMD)
VPS4A

Disorders for VPS4A Gene

Relevant External Links for VPS4A

Genetic Association Database (GAD)
VPS4A
genes like me logo Genes that share disorders with VPS4A: view

No data available for UniProtKB/Swiss-Prot for VPS4A Gene

Publications for VPS4A Gene

  1. ATPase-defective mammalian VPS4 localizes to aberrant endosomes and impairs cholesterol trafficking. (PMID: 10637304) Bishop N. … Woodman P. (Mol. Biol. Cell 2000) 2 3 4 23
  2. Mammalian cells express two VPS4 proteins both of which are involved in intracellular protein trafficking. (PMID: 11563910) Scheuring S. … Koehrer K. (J. Mol. Biol. 2001) 2 3 4 23
  3. Comparative sequence and expression analyses of four mammalian VPS4 genes. (PMID: 12594041) Beyer A. … Koehrer K. (Gene 2003) 3 4 23
  4. Structure and ESCRT-III protein interactions of the MIT domain of human VPS4A. (PMID: 16174732) Scott A. … Sundquist W.I. (Proc. Natl. Acad. Sci. U.S.A. 2005) 3 4 23
  5. Structural and mechanistic studies of VPS4 proteins. (PMID: 16193069) Scott A. … Sundquist W.I. (EMBO J. 2005) 3 4 23

Products for VPS4A Gene

Sources for VPS4A Gene

Back to Top

Content