VPS4A Gene
protein-coding GIFtS: 53
GCID: GC16P069335
|
|
vacuolar protein sorting 4 homolog A (S. cerevisiae)(Previous names: vacuolar protein sorting 4A (yeast homolog), vacuolar protein...)
| |
Aliases
for VPS4A gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Vacuolar Protein Sorting 4 Homolog A (S. Cerevisiae)1 2 | | Vacuolar Protein Sorting 4A (Yeast Homolog)1 | | VPS41 2 3 5 | | Vacuolar Protein Sorting 4A (Yeast)1 | | VPS4-11 2 3 | | SKD1-Homolog1 | | SKD11 2 | | Vacuolar Protein Sorting Factor 4A2 | | SKD1A1 2 | | Vacuolar Protein Sorting-Associated Protein 4A2 | | SKD21 2 | | Vacuolar Sorting Protein 42 | | HVPS41 | | EC 3.6.4.63 | | FLJ221971 | | Protein SKD23 |
Export aliases for VPS4A gene to outside databasesPrevious GC identifers: GC16P060030 GC16P069723 GC16P069080 GC16P069121 GC16P067902 GC16P069345 GC16P055223 |
Summaries
for VPS4A gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for VPS4A:
The protein encoded by this gene is a member of the AAA protein family (ATPases associated with diverse cellularactivities), and is the homolog of the yeast Vps4 protein. In humans, two paralogs of the yeast protein have beenidentified. The former share a high degree of aa sequence similarity with each other, and also with yeast Vps4 andmouse Skd1 proteins. The mouse Skd1 (suppressor of K+ transport defect 1) has been shown to be really an yeast Vps4ortholog. Functional studies indicate that both human paralogs associate with the endosomal compartments, and areinvolved in intracellular protein trafficking, similar to Vps4 protein in yeast. The gene encoding this paralog hasbeen mapped to chromosome 16; the gene for the other resides on chromosome 18. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: VPS4A_HUMAN, Q9UN37Function: Involved in late steps of the endosomal multivesicular bodies (MVB) pathway. Recognizes membrane-associatedESCRT-III assemblies and catalyzes their disassembly, possibly in combination with membrane fission. Redistributes theESCRT-III components to the cytoplasm for further rounds of MVB sorting. MVBs contain intraluminal vesicles (ILVs)that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered tolysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes andlipids. In conjunction with the ESCRT machinery also appears to function in topologically equivalent membrane fissionevents, such as the terminal stages of cytokinesis and enveloped virus budding (HIV-1 and other lentiviruses).Involved in cytokinesis
Gene Wiki entry for VPS4A
|
Genomic Views
for VPS4A gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000016.9 NC_018927.1 NT_010498.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the VPS4A gene promoter:
c-Fos AP-1 Pax-5 Pbx1a NRSF form 1 NRSF form 2 HNF-4alpha1 GATA-1 AREB6 HSF2
Other transcription factors
Search SABiosciences Chromatin IP Primers for VPS4A
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat VPS4A |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 16q22.1 Ensembl cytogenetic band: 16q22.1 HGNC cytogenetic band: 16q23.1VPS4A Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 16 GeneLoc Exon Structure GeneLoc location for GC16P069335: view genomic region
(about GC identifiers)
Start:
|
69,333,562 bp from pter |
End:
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69,358,949 bp from pter |
Size:
|
25,388 bases |
Orientation:
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plus strand |
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Proteins
for VPS4A gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: VPS4A_HUMAN, Q9UN37 (See
protein sequence)Recommended Name: Vacuolar protein sorting-associated protein 4A Size: 437 amino acids; 48898 Da
Subunit: Proposed to be monomeric or homodimeric in nucleotide-free form and to oligomerize upon binding to ATP to formtwo stacked hexameric or heptameric rings with a central pore through which ESCRT-III substrates are translocated inan ATP-dependent manner (By similarity). Interacts with CHMP1A, CHMP1B, CHMP2A, CHMP2B, CHMP3, CHMP4A, CHMP4B, CHMP4Cand CHMP6. Interacts with VPS4B; the interaction suggests a heteromeric assembly with VPS4B. Interacts with SPAST.Interacts with IST1
Subcellular location: Prevacuolar compartment membrane; Peripheral membrane protein. Late endosome membrane; Peripheralmembrane protein (Probable). Note=Membrane-associated in the prevacuolar endosomal compartment. Localizes to themidbody of dividing cells. Localized in two distinct rings on either side of the Fleming body
Sequence caution: Sequence=AAL75948.1; Type=Frameshift; Positions=123, 133, 157, 163;
3 PDB 3D structures from  and Proteopedia  for VPS4A:1YXR (3D)
2JQ9 (3D)
2K3W (3D)
Secondary accessions: B2RCB7 Q8TF07 Q9UI03 Q9Y582Explore the universe of human proteins at neXtProt for VPS4A: NX_Q9UN37
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9UN37
VPS4A Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_037377.1
ENSEMBL proteins: ENSP00000254950 Reactome Protein details: Q9UN37
Human Recombinant Protein Products:
Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table
VPS4A for ontologies About GeneDecksing
VPS4A Antibody Products:
Assay Products for VPS4A: |
Protein
Domains /
Families
for VPS4A gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
VPS4A for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9UN37ProtoNet protein and cluster: Q9UN37 2 Blocks protein families: IPB003960 AAA-protein subdomain IPB007330 MIT
UniProtKB/Swiss-Prot: VPS4A_HUMAN, Q9UN37Domain: The MIT domain serves as an adapter for ESCRT-III proteins. It forms an asymmetric three-helix bundle thatbinds amphipathic MIM (MIT interacting motif) helices along the groove between MIT helices 2 and 3 present in a subsetof ESCRT-III proteins thus establishing the canonical MIM-MIT interaction. In an extended conformation along thegroove between helices 1 and 3, also binds to a type-2 MIT interacting motif (MIM2)Similarity: Belongs to the AAA ATPase familySimilarity: Contains 1 MIT domain |
Function
for VPS4A gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: VPS4A_HUMAN, Q9UN37Function: Involved in late steps of the endosomal multivesicular bodies (MVB) pathway. Recognizes membrane-associatedESCRT-III assemblies and catalyzes their disassembly, possibly in combination with membrane fission. Redistributes theESCRT-III components to the cytoplasm for further rounds of MVB sorting. MVBs contain intraluminal vesicles (ILVs)that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered tolysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes andlipids. In conjunction with the ESCRT machinery also appears to function in topologically equivalent membrane fissionevents, such as the terminal stages of cytokinesis and enveloped virus budding (HIV-1 and other lentiviruses).Involved in cytokinesisCatalytic activity: ATP + H(2)O = ADP + phosphateEnzyme Number (IUBMB): EC 3.6.4.61
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for VPS4A (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for VPS4A
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: VPS4A (NM_013245) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for VPS4A | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VPS4A |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VPS4A |
Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table
VPS4A for ontologies About GeneDecksing
4 GenomeRNAi human phenotypes for VPS4A:
Animal Models:
1 MGI phenotypic allele  for Vps4a (no phenotypes)
VPS4A for phenotypes About GeneDecksing
|
Pathways & Interactions
for VPS4A gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Membrane Trafficking | | | 2 | CXCR4-mediated signaling events | | | 3 | Endocytosis | | | 4 | Signal Transduction | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1  BioSystems Pathway for VPS4A
2 
Reactome Pathways for VPS4A
1 
Kegg Pathway (Kegg details for VPS4A):
VPS4A for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for VPS4A
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/39 Interacting proteins for VPS4A (Q9UN372, 3 ENSP000002549504) via UniProtKB, MINT, STRING, and/or I2D (see all 39)About this table
Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table
VPS4A for ontologies About GeneDecksing
|
Drugs & Compounds
for VPS4A gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
VPS4A for compounds About GeneDecksing
 Browse Tocris compounds for VPS4A
1 Novoseek chemical compound relationship for VPS4A gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| atp |
19.3 |
5 |
16193069 (1), 10637304 (1), 17408385 (1) |
Search CenterWatch for drugs/clinical trials and news about VPS4A
|
Transcripts
for VPS4A gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for VPS4A gene: NM_013245.2 Unigene Cluster for VPS4A: Vacuolar protein sorting 4 homolog A (S. cerevisiae) Hs.128420 [show with all ESTs]Unigene Representative Sequence: AK0923725 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000569775 ENST00000254950(uc002eww.3) ENST00000562754 ENST00000564399
ENST00000566354
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for VPS4A (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for VPS4A
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: VPS4A (NM_013245) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for VPS4A | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VPS4A |
Additional cDNA sequence: AF112215.1 AF132747.1 AF155740.1 AF159063.1 AF255952.1 AK000200.1 AK025850.1 AK092372.1 AK315026.1 AL133634.1 BC013021.2 BC035121.1 BC047932.1 17 DOTS entries: DT.100654733 DT.447740 DT.100791140 DT.101984310 DT.91838215 DT.97839394 DT.120681088 DT.100791136 DT.100769230 DT.100791139 DT.100791143 DT.100892940 DT.120681031 DT.120681079 DT.95171111 DT.100791128 DT.97839393 24/648 AceView cDNA sequences (see all 648): BC047932 AA515681 M85872 BU507064 CR603988 AL582940 BU509009 AL602980 BQ705947 AI492564 CD370211 Z41804 AI432600 AA989448 T07402 F26818 CA447535 BQ058102 BQ933775 AA035253 AA418261 AW276544 CN482550 BQ021302
GeneLoc Exon Structure
|
Expression
for VPS4A gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| VPS4A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCAACAGCCA
About this image
See VPS4A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for VPS4A
SOURCE GeneReport for Unigene cluster: Hs.128420
UniProtKB/Swiss-Prot: VPS4A_HUMAN, Q9UN37Tissue specificity: Ubiquitously expressed
SABiosciences Expression via Pathway-Focused PCR Array including VPS4A: | HIV Host Response in human mouse rat |
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for VPS4A
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat VPS4A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat VPS4A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat VPS4A | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VPS4A |
Orthologs
for VPS4A gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for VPS4A gene from 7/29 species (see all 29) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
VPS4A1 |
vacuolar protein sorting 4 homolog A (S. cerevisiae) |
83.57(n)
91.4(a) |
|
425637 XM_423372.3 XP_423372.3 |
lizard
(Anolis carolinensis) |
Reptilia |
VPS4A6 |
-- |
90(a) |
1 ↔ 1 |
GL343643.1(26424-30825) |
zebrafish
(Danio rerio) |
Actinopterygii |
vps4a1 |
vacuolar protein sorting 4a (yeast) |
80.23(n)
90.07(a) |
|
767670 NM_001076609.1 NP_001070077.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
BcDNA:GH026783 |
intracellular protein transport
adenosinetriphosphatase |
72(a)
(best of 3) |
|
-- |
worm
(Caenorhabditis elegans) |
Secernentea |
Y34D9A.103 |
-- |
57(a)
(best of 3) |
|
I(1065980-1066871) -- |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
ATSKD16 |
vacuolar protein-sorting-associated protein 4 |
53(a) |
1 → many |
2(11781038-11783992) |
rice
(Oryza sativa) |
Liliopsida |
----(see all 3) |
vacuolar protein sorting-associating protein 4B, p...vacuolar protein sorting-associated protein 4, put...(see all 3) |
53(a)50(a)(see all 3) |
many ↔ manymany ↔ many(see all 3) |
1(2214586-2221837) 2(3234307-3237981) |
ENSEMBL Gene Tree for VPS4A (if available)
TreeFam Gene Tree for VPS4A (if available) |
Paralogs
for VPS4A gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for VPS4A gene
- VPS4B2 ENSG000002609142 KATNAL12 KATNA12 KATNAL22
7 SIMAP similar genes for VPS4A using alignment to 2 protein entries: VPS4A_HUMAN (see all proteins):DKFZp434E0418 VPS4B KATNAL2 FIGNL1 KATNAL1 KATNA1
FIGN
VPS4A for paralogs About GeneDecksing
|
Genomic Variants
for VPS4A gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 16 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for VPS4A (69333562 - 69358949 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for VPS4A: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing VPS4A |
|
Disorders
/ Diseases
for VPS4A gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
VPS4A for disorders About GeneDecksing
OMIM gene information: 609982
OMIM disorders: --
9  diseases for VPS4A: About MalaCardsnorth american indian childhood cirrhosis hepatitis e hepatitis c stomatitis
hepatitis b conjunctivitis hepatitis influenza
cholesterol
Export disorders for VPS4A gene to outside databases
|
Publications
for VPS4A gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for VPS4A gene, integrated from 9 sources (see all 82):
(articles sorted by number of sources associating them with VPS4A) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Mammalian cells express two VPS4 proteins both of which are involved in intracellular protein trafficking. (PubMed id 11563910)1, 2, 3, 9 Scheuring S.... Koehrer K. (2001)
- Comparative sequence and expression analyses of four mammalian VPS4 genes. (PubMed id 12594041)1, 2, 9 Beyer A....Koehrer K. (2003)
- ATPase-defective mammalian VPS4 localizes to aberrant endosomes and impairs cholesterol trafficking. (PubMed id 10637304)2, 3, 9 Bishop N. and Woodman P. (2000)
- Biochemical analyses of human IST1 and its function in cytokinesis. (PubMed id 19129479)1, 2, 9 Bajorek M....Sundquist W.I. (2009)
- Two distinct modes of ESCRT-III recognition are required for VPS4 functions in lysosomal protein targeting and HIV-1 budding. (PubMed id 18606141)1, 2, 9 Kieffer C....Sundquist W.I. (2008)
- ESCRT-III recognition by VPS4 ATPases. (PubMed id 17928862)1, 2, 9 Stuchell-Brereton M.D.... Sundquist W.I. (2007)
- Human ESCRT and ALIX proteins interact with proteins of the midbody and function in cytokinesis. (PubMed id 17853893)1, 2, 9 Morita E....Sundquist W.I. (2007)
- Structure and ESCRT-III protein interactions of the MIT domain of human VPS4A. (PubMed id 16174732)1, 2, 9 Scott A....Sundquist W.I. (2005)
- ATPase-deficient hVPS4 impairs formation of internal endosomal vesicles and stabilizes bilayered clathrin coats on endosomal vacuoles. (PubMed id 15075231)1, 2 Sachse M.... Klumperman J. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
|
External Searches for VPS4A gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing VPS4A gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing VPS4A gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing VPS4A gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for VPS4A | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for VPS4A gene:
Search GeneIP for patents involving VPS4A
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for VPS4A gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for VPS4A | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for VPS4A | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for VPS4A | | | OriGene Protein Over-expression Lysate for VPS4A | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for VPS4A | | OriGene 3'-UTR Clone for VPS4A | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for VPS4A | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for VPS4A | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for VPS4A | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for VPS4A | | OriGene Custom Protein Services for VPS4A | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat VPS4A | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing VPS4A | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat VPS4A | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat VPS4A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat VPS4A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat VPS4A |
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| | | | Search Tocris compounds for VPS4A |
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 | | | VPS4A Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VPS4A |
|  |  |  | | | | Search ThermoFisher Antibodies for VPS4A |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VPS4A |
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