Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

VPS45 Gene

protein-coding   GIFtS: 56
GCID: GC01P150039

Vacuolar Protein Sorting 45 Homolog (S. Cerevisiae)

(Previous names: vacuolar protein sorting 45A (yeast homolog), vacuolar protein...)
(Previous symbols: VPS45B, VPS45A)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Vacuolar Protein Sorting 45 Homolog (S. Cerevisiae)1 2     SCN52
VPS45A1 2 3 5     VPS54A2
VPS45B1 2 3     VSP452
hlVps452 3     VSP45A2
Vacuolar Protein Sorting 45A (Yeast Homolog)1     Leucocyte Vacuolar Protein Sorting 452
Vacuolar Protein Sorting 45A (Yeast)1     Vacuolar Protein Sorting 45A2
H12     Vacuolar Protein Sorting-Associated Protein 452
H1VPS452     h-VPS453

External Ids:    HGNC: 145791   Entrez Gene: 113112   Ensembl: ENSG000001366317   OMIM: 6100355   UniProtKB: Q9NRW73   

Export aliases for VPS45 gene to outside databases

Previous GC identifers: GC01P148306 GC01P121419


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for VPS45 Gene:
Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct
organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved
in vesicle transport to vacuoles. This gene is a member of the Sec1 domain family, and shows a high degree of
sequence similarity to mouse, rat and yeast Vps45. The exact function of this gene is not known, but its high
expression in peripheral blood mononuclear cells suggests a role in trafficking proteins, including inflammatory
mediators. Multiple alternatively spliced transcript variants have been found for this gene. (provided by RefSeq,
Jul 2013)

GeneCards Summary for VPS45 Gene: 
VPS45 (vacuolar protein sorting 45 homolog (S. cerevisiae)) is a protein-coding gene. Diseases associated with VPS45 include prostatitis, and among its related super-pathways are Delta508-CFTR traffic / Sorting endosome formation in CF and Clathrin-dependent protein traffic. GO annotations related to this gene include molecular_function.

UniProtKB/Swiss-Prot: VPS45_HUMAN, Q9NRW7
Function: May play a role in vesicle-mediated protein trafficking from the Golgi stack through the trans-Golgi
network

Gene Wiki entry for VPS45 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_004487.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the VPS45 gene promoter:
         Nkx3-1   Nkx3-1 v4   Brachyury   Nkx3-1 v1   STAT5A   IRF-1   Nkx3-1 v2   Nkx3-1 v3   LHX3a/Lhx3a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidVPS45 promoter sequence
   Search SABiosciences Chromatin IP Primers for VPS45

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat VPS45


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21.2   Ensembl cytogenetic band:  1q21.2   HGNC cytogenetic band: 1q21.2

VPS45 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
VPS45 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P150039:  view genomic region     (about GC identifiers)

Start:
150,039,342 bp from pter      End:
150,117,505 bp from pter
Size:
78,164 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: VPS45_HUMAN, Q9NRW7 (See protein sequence)
Recommended Name: Vacuolar protein sorting-associated protein 45  
Size: 570 amino acids; 65077 Da
Subunit: Interacts with STX6 (By similarity). Interacts with ZFYVE20
Subcellular location: Golgi apparatus membrane; Peripheral membrane protein (By similarity). Endosome membrane;
Peripheral membrane protein (By similarity). Note=Associated with Golgi/endosomal vesicles and the trans-Golgi
network (By similarity)
Secondary accessions: D3DUZ9 Q15715 Q5T4P6 Q9Y4Z6

Explore the universe of human proteins at neXtProt for VPS45: NX_Q9NRW7

Explore proteomics data for VPS45 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9NRW7

  • VPS45 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    VPS45 Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_001266282.1  NP_001266283.1  NP_001266284.1  NP_009190.2  

    ENSEMBL proteins: 
     ENSP00000358126   ENSP00000400143   ENSP00000440690   ENSP00000358124  
    Reactome Protein details: Q9NRW7
    Human Recombinant Protein Products for VPS45: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for VPS45
    OriGene Protein Over-expression Lysate for VPS45
    OriGene MassSpec for VPS45 
    OriGene Custom Protein Services for VPS45
    GenScript Custom Purified and Recombinant Proteins Services for VPS45
    Novus Biologicals VPS45 Protein
    Novus Biologicals VPS45 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for VPS45 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IEA--
    GO:0005575cellular_component ND--
    GO:0005794Golgi apparatus ISS--
    GO:0010008endosome membrane TAS--
    GO:0016021integral to membrane ISS--

    VPS45 for ontologies           About GeneDecksing



    VPS45 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for VPS45
    OriGene Custom Antibody Services for VPS45
    GenScript Custom Superior Antibodies Services for VPS45
    Novus Biologicals VPS45 Antibodies
    Abcam antibodies for VPS45
    Cloud-Clone Corp. Antibodies for VPS45 
    ThermoFisher Antibodies for VPS45
    LSBio Antibodies in human, mouse, rat for VPS45 

    Assay Products for VPS45: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for VPS45
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for VPS45
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for VPS45 
    Cloud-Clone Corp. CLIAs for VPS45


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR001619 Sec1-like
     IPR027482 Sec-1-like_dom2

    Graphical View of Domain Structure for InterPro Entry Q9NRW7

    ProtoNet protein and cluster: Q9NRW7

    1 Blocks protein domain: IPB001619 Sec1-like protein

    UniProtKB/Swiss-Prot: VPS45_HUMAN, Q9NRW7
    Similarity: Belongs to the STXBP/unc-18/SEC1 family


    VPS45 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: VPS45_HUMAN, Q9NRW7
    Function: May play a role in vesicle-mediated protein trafficking from the Golgi stack through the trans-Golgi
    network

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0005515protein binding ----
         
    VPS45 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for VPS45:
     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for VPS45 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for VPS45

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for VPS45 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for VPS45 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat VPS45
    8 QIAGEN miScript miRNA Assays for microRNAs that regulate VPS45:
    hsa-miR-1290 hsa-miR-206 hsa-miR-485-3p hsa-miR-1 hsa-miR-619 hsa-miR-613 hsa-miR-1286 hsa-miR-143*
    SwitchGear 3'UTR luciferase reporter plasmidVPS45 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for VPS45
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat VPS45

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for VPS45
    Sirion Biotech Customized adenovirus for overexpression of VPS45

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for VPS45 (see all 7)
    OriGene ORF clones in mouse, rat for VPS45
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: VPS45 (NM_007259)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for VPS45
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VPS45
    Sirion Biotech Customized lentivirus for stable overexpression of VPS45 
                         Customized lentivirus expression plasmids for stable overexpression of VPS45 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for VPS45
    Search LifeMap BioReagents cell lines for VPS45
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VPS45


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for VPS45 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Normal wtCFTR traffic / Sorting endosome formation
    Delta508-CFTR traffic / Sorting endosome formation in CF0.77
    Normal wtCFTR traffic / Sorting endosome formation0.77
    2Clathrin-dependent protein traffic
    Transport Clathrin-coated vesicle cycle0.66
    3Platelet activation, signaling and aggregation
    Hemostasis0.43
    4Factors involved in megakaryocyte development and platelet production
    Factors involved in megakaryocyte development and platelet production
    5Endocytosis
    Endocytosis

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 GeneGo (Thomson Reuters) Pathways for VPS45
        Normal wtCFTR traffic / Sorting endosome formation
    Delta508-CFTR traffic / Sorting endosome formation in CF
    Transport Clathrin-coated vesicle cycle

    2        Reactome Pathways for VPS45
        Hemostasis
    Factors involved in megakaryocyte development and platelet production


    1         Kegg Pathway  (Kegg details for VPS45):
        Endocytosis


    VPS45 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for VPS45

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/52 Interacting proteins for VPS45 (Q9NRW73 ENSP000003581264) via UniProtKB, MINT, STRING, and/or I2D (see all 52)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NAPBQ9H1153, ENSP000003662254I2D: score=4 STRING: ENSP00000366225
    PSMD3O432423, ENSP000002646394I2D: score=3 STRING: ENSP00000264639
    VPS18Q9P2533, ENSP000002205094I2D: score=3 STRING: ENSP00000220509
    STX16O146623, ENSP000003601834I2D: score=2 STRING: ENSP00000360183
    AP3D1O146173, ENSP000003440554I2D: score=1 STRING: ENSP00000344055
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006886intracellular protein transport NAS10404641
    GO:0006904vesicle docking involved in exocytosis IEA--
    GO:0007596blood coagulation TAS--
    GO:0016192vesicle-mediated transport ----

    VPS45 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for VPS45

    Search CenterWatch for drugs/clinical trials and news about VPS45

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for VPS45 gene (4 alternative transcripts): 
    NM_001279353.1  NM_001279354.1  NM_001279355.1  NM_007259.4  

    Unigene Cluster for VPS45:

    Vacuolar protein sorting 45 homolog (S. cerevisiae)
    Hs.443750  [show with all ESTs]
    Unigene Representative Sequence: NM_007259
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000369130(uc010pbr.1 uc009wlm.1 uc010pbp.1 uc001etp.3 uc010pbq.2 uc001etq.3)
    ENST00000462852 ENST00000478999 ENST00000460366 ENST00000497638 ENST00000419023
    ENST00000477558 ENST00000472756 ENST00000491789 ENST00000484306 ENST00000535106
    ENST00000369128(uc010pbs.2)
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat VPS45
    8 QIAGEN miScript miRNA Assays for microRNAs that regulate VPS45:
    hsa-miR-1290 hsa-miR-206 hsa-miR-485-3p hsa-miR-1 hsa-miR-619 hsa-miR-613 hsa-miR-1286 hsa-miR-143*
    SwitchGear 3'UTR luciferase reporter plasmidVPS45 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for VPS45
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat VPS45
    Clone
    Products:
         
    OriGene clones in human, mouse for VPS45 (see all 7)
    OriGene ORF clones in mouse, rat for VPS45
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: VPS45 (NM_007259)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for VPS45
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VPS45
    Sirion Biotech Customized lentivirus for stable overexpression of VPS45 
                         Customized lentivirus expression plasmids for stable overexpression of VPS45 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for VPS45
    OriGene qSTAR qPCR primer pairs in human, mouse for VPS45
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat VPS45
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat VPS45
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat VPS45

    Additional mRNA sequence: 

    AF165513.1 AJ133421.1 AK023170.1 AK223214.1 AK293555.1 AK295529.1 AK298786.1 AK298835.1 
    AK301994.1 AK307949.1 AY453586.1 BC012932.1 BC028382.2 

    19 DOTS entries:

    DT.447459  DT.95284029  DT.95194412  DT.100803657  DT.75164560  DT.95194417  DT.95239400  DT.121414882 
    DT.416990  DT.97845520  DT.99988117  DT.40113939  DT.92463595  DT.95194400  DT.95194413  DT.100803655 
    DT.40132558  DT.92463612  DT.95194414 

    24/253 AceView cDNA sequences (see all 253):

    AA515662 CA417282 CA433698 AU131412 BC028382 AA291962 BQ001991 AI057492 
    N50867 BM563489 BM454221 AL711074 AA855120 BM681711 BQ002220 BM997146 
    BU528438 CB250663 AA317032 AA877408 BX493159 BI770084 BM708815 CB159551 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for VPS45 (see all 10)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a ·
    SP1:                                            -           -                 -           -                 -     -                                             
    SP2:                                            -           -                 -     -     -     -     -     -     -                                             
    SP3:                                                        -                 -           -                 -     -                                             
    SP4:                    -     -     -     -     -           -                 -           -                                                                     
    SP5:                                            -           -                 -                                                                                 

    ExUns: 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b
    SP1:                    -                     
    SP2:                                          
    SP3:                                          
    SP4:                                          
    SP5:                                          


    ECgene alternative splicing isoforms for VPS45

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    VPS45 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATGACCACA
    VPS45 Expression
    About this image


    See VPS45 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for VPS45

    SOURCE GeneReport for Unigene cluster: Hs.443750

    UniProtKB/Swiss-Prot: VPS45_HUMAN, Q9NRW7
    Tissue specificity: Ubiquitous. Expression was highest in testis, heart and brain, intermediate in kidney, spleen,
    prostate, ovary, small intestine and thymus and low in lung, skeletal muscle, placenta, colon, pancreas,
    peripheral blood leukocytes and liver

        SABiosciences Expression via Pathway-Focused PCR Array including VPS45: 
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for VPS45
    OriGene qSTAR qPCR primer pairs in human, mouse for VPS45
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat VPS45
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat VPS45
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat VPS45
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VPS45

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for VPS45 gene from 10/24 species (see all 24)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Vps451 , 5 vacuolar protein sorting 45 (yeast)1, 5 90.88(n)1
    97.02(a)1
      3 (41.65 cM)5
    223651  NM_013841.31  NP_038869.11 
     959998325 
    chicken
    (Gallus gallus)
    Aves VPS451 vacuolar protein sorting 45 homolog (S. cerevisiae) 79.89(n)
    92.39(a)
      430741  NM_001031593.1  NP_001026764.1 
    lizard
    (Anolis carolinensis)
    Reptilia VPS456
    Uncharacterized protein
    80(a)
    1 ↔ 1
    GL345017.1(21-12645)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.87032 Xenopus laevis transcribed sequence with moderate similarity more 78.17(n)    BU912999.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.158742 Transcribed sequence with moderate similarity to protein more 75.23(n)    57089617 
    fruit fly
    (Drosophila melanogaster)
    Insecta Vps451 Vacuolar protein sorting 45 56.66(n)
    55.52(a)
      41153  NM_141652.1  NP_649909.1 
    worm
    (Caenorhabditis elegans)
    Secernentea vps-451 Protein VPS-45 51.54(n)
    48.96(a)
      180449  NM_171622.3  NP_741714.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes VPS45(YGL095C)4
    VPS451
    Protein of the Sec1p/Munc-18 family, essential for more4
    Vps45p1
    49.07(n)1
    39.88(a)1
      7(330607-328874)4
    8527851, 4  NP_011420.31  NP_011420.14 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons VPS451 vacuolar protein sorting-associated protein 45-like more 52.6(n)
    47.1(a)
      844050  NM_106364.1  NP_565150.1 
    rice
    (Oryza sativa)
    Liliopsida AK066001.12   -- 77.44(n)    AK066001.1 


    ENSEMBL Gene Tree for VPS45 (if available)
    TreeFam Gene Tree for VPS45 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for VPS45 gene
    2 SIMAP similar genes for VPS45 using alignment to 4 protein entries:     VPS45_HUMAN (see all proteins):
    ADAM10    ARMC6

    VPS45 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1517 SNPs in VPS45 are shown (see all 1517)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1854438711,2
    C--121497880(+) AATCAC/TTTAAT 1 -- ds50010--------
    rs1504996191,2
    --150037406(+) TCTATA/CCTTAA 1 -- us2k10--------
    rs1882123731,2
    --150037411(+) CCTTAA/CAGCAC 1 -- us2k10--------
    rs1807018981,2
    C--150037453(+) TCAAGA/TTGAAG 1 -- us2k10--------
    rs75209301,2
    C,F,A,H--150037560(+) GTTTAC/TTTATA 1 -- us2k1 tfbs321Minor allele frequency- T:0.37NS EA NA WA CSA 2010
    rs557300681,2
    C,F--150037636(+) AAGTAA/CCTGGG 1 -- us2k12Minor allele frequency- C:0.12WA 120
    rs1437343331,2
    C--150037774(+) CTTCA-/GGAAGG 1 -- us2k10--------
    rs1398152161,2
    --150037788(+) GATGCA/TGTCTA 1 -- us2k10--------
    rs2010228721,2
    C--150037853(+) TGTTTA/TTTTTT 1 -- us2k10--------
    rs2018317091,2
    C--150037855(+) TTTTTG/TTTTTT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for VPS45 (150039342 - 150117505 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for VPS45:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2061124CNV Deletion18987734
    esv2605621CNV Deletion19546169
    nsv831537CNV Loss17160897

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing VPS45
    DNA2.0 Custom Variant and Variant Library Synthesis for VPS45

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 610035    OMIM disorders: --

    2 diseases for VPS45:    About MalaCards
    prostatitis    


    VPS45 for disorders           About GeneDecksing


    Export disorders for VPS45 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for VPS45 gene, integrated from 9 sources (see all 31):
    (articles sorted by number of sources associating them with VPS45)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Mammalian homologues of yeast vacuolar protein sorting (vps) genes implicated in Golgi-to-lysosome trafficking. (PubMed id 8996080)1, 2, 3 Pevsner J.... Scheller R.H. (1996)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. Divalent Rab effectors regulate the sub-compartmental organization and sorting of early endosomes. (PubMed id 11788822)1, 2 de Renzis S.... Zerial M. (2002)
    5. Rabenosyn-5, a novel Rab5 effector, is complexed with hVPS45 and recruited to endosomes through a FYVE finger domain. (PubMed id 11062261)1, 2 Nielsen E.... Zerial M. (2000)
    6. Molecular cloning and characterization of a cDNA encoding the human leucocyte vacuolar protein sorting (hlVps45). (PubMed id 10404641)1, 2 Rajasekariah P.... Sutherland G.R. (1999)
    7. The Thr224Asn mutation in the VPS45 gene is associated with the congenital neutropenia and primary myelofibrosis of infancy. (PubMed id 23599270)1 Stepensky P....Mevorach D. (2013)
    8. A congenital neutrophil defect syndrome associated wit h mutations in VPS45. (PubMed id 23738510)1 Vilboux T....Somech R. (2013)
    9. Proteome-wide identification of ubiquitylation sites b y conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)1 Oshikawa K....Nakayama K.I. (2012)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 11311 HGNC: 14579 AceView: VPS45A Ensembl:ENSG00000136631 euGenes: HUgn11311
    ECgene: VPS45 Kegg: 11311 H-InvDB: VPS45

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for VPS45 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for VPS45 gene:
    Search GeneIP for patents involving VPS45

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for VPS45   OriGene RNAi products in human, mouse, rat for VPS45  
     OriGene qPCR primer pairs and template standards for VPS45   OriGene Protein Over-expression Lysate for VPS45  
     OriGene MassSpec something-or-other for VPS45   OriGene clones in human, mouse for VPS45  
     OriGene qSTAR qPCR primer pairs in human, mouse for VPS45   OriGene Purified Protein for VPS45  
     OriGene ORF clones in mouse, rat for VPS45   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for VPS45   OriGene Custom Protein Services for VPS45  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat VPS45
     QIAGEN SeqTarget long-range PCR primers for resequencing VPS45
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat VPS45
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat VPS45
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat VPS45
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat VPS45
     GenScript Custom Purified and Recombinant Proteins Services for VPS45 GenScript cDNA clones with any tag delivered in your preferred vector for VPS45
     GenScript Custom Assay Services for VPS45 GenScript Custom Superior Antibodies Services for VPS45
     GenScript Custom overexpressing Cell Line Services for VPS45 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in VPS45 promoter
     Search Chromatin IP Primers for VPS45
     RT2 qPCR Primer Assay in human, mouse, rat VPS45
     Search GNC Networks for VPS45
     SABiosciences PCR Arrays including human, mouse, rat VPS45
     Search Tocris compounds for VPS45
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     VPS45 antibodies
     VPS45 proteins
     VPS45 lysates
     Antibodies for VPS45
     See all of Abcam's Antibodies, Kits and Proteins for VPS45
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for VPS45
     Antibodies for VPS45
     ELISAs for VPS45
     CLIAs for VPS45
     Search LifeMap BioReagents cell lines for VPS45
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VPS45
     SwitchGear 3'UTR luciferase reporter plasmids for VPS45
     SwitchGear Promoter luciferase reporter plasmids for VPS45
     ThermoFisher Antibodies for VPS45
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VPS45
     inGenious Targeting Laboratory - Custom generated mouse model solutions for VPS45
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for VPS45
    Customized:
     lentivirus for stable overexpression of VPS45
     lentivirus expression plasmids for stable overexpression of VPS45
     adenovirus for overexpression of VPS45
     LSBio Antibodies in human, mouse, rat for VPS45
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      VPS45 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4