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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

VPS41 Gene

protein-coding   GIFtS: 56
GCID: GC07M039137

Vacuolar Protein Sorting 41 Homolog (S. Cerevisiae)

(Previous names: vacuolar protein sorting 41 (yeast homolog), vacuolar protein...)
Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Vacuolar Protein Sorting 41 Homolog (S. Cerevisiae)1 2     HVSP412
S532 3     hVps41p2
Vacuolar Protein Sorting 41 (Yeast Homolog)1     Vacuolar Assembly Protein 412
Vacuolar Protein Sorting 41 (Yeast)1     Vacuolar Protein Sorting-Associated Protein 41 Homolog2
HVPS412     

External Ids:    HGNC: 127131   Entrez Gene: 270722   Ensembl: ENSG000000067157   OMIM: 6054855   UniProtKB: P497543   

Export aliases for VPS41 gene to outside databases

Previous GC identifers: GC07M038409 GC07M038470 GC07M038504 GC07M038536 GC07M038730 GC07M038913


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for VPS41 Gene:
Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct
organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved
in vesicle transport to vacuoles. This gene encodes the human ortholog of yeast Vps41 protein which is also
conserved in Drosophila, tomato, and Arabidopsis. Expression studies in yeast and human indicate that this
protein may be involved in the formation and fusion of transport vesicles from the Golgi. Several transcript
variants encoding different isoforms have been described for this gene, however, the full-length nature of not
all is known. (provided by RefSeq, Jul 2008)

GeneCards Summary for VPS41 Gene: 
VPS41 (vacuolar protein sorting 41 homolog (S. cerevisiae)) is a protein-coding gene. Diseases associated with VPS41 include alzheimer's disease, and parkinson's disease. GO annotations related to this gene include microtubule binding and molecular_function.

UniProtKB/Swiss-Prot: VPS41_HUMAN, P49754
Function: Required for vacuolar assembly and vacuolar traffic




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.2  NT_007819.17  NT_079592.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the VPS41 gene promoter:
         USF1   STAT1   GATA-3   AML1a   GATA-1   GATA-2   FAC1   SREBP-1a   USF-1   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 5): VPS41 promoter sequence
   Search SABiosciences Chromatin IP Primers for VPS41

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat VPS41


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p14-p13   Ensembl cytogenetic band:  7p14.1   HGNC cytogenetic band: 7p14.1-p13

VPS41 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
VPS41 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M039137:  view genomic region     (about GC identifiers)

Start:
38,762,563 bp from pter      End:
38,971,994 bp from pter
Size:
209,432 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 38,801,230-38,986,499     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: VPS41_HUMAN, P49754 (See protein sequence)
Recommended Name: Vacuolar protein sorting-associated protein 41 homolog  
Size: 854 amino acids; 98566 Da
Secondary accessions: Q86TP8 Q99851 Q99852
Alternative splicing: 2 isoforms:  P49754-1   P49754-2   

Explore the universe of human proteins at neXtProt for VPS41: NX_P49754

Explore proteomics data for VPS41 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P49754

  • VPS41 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    VPS41 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_055211.2  NP_542198.2  

    ENSEMBL proteins: 
     ENSP00000309457   ENSP00000379297   ENSP00000391980   ENSP00000395410   ENSP00000412974  
     ENSP00000265745   ENSP00000411919   ENSP00000407835   ENSP00000398584  

    Human Recombinant Protein Products for VPS41: 
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    Novus Biologicals VPS41 Proteins
    Novus Biologicals VPS41 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for VPS41 

    Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005765lysosomal membrane IDA17897319
    GO:0005769early endosome IEA--
    GO:0005770late endosome IEA--
    GO:0005798Golgi-associated vesicle IMP11412045
    GO:0005829cytosol IDA11412045

    VPS41 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/7 InterPro protein domains (see all 7):
     IPR011990 TPR-like_helical
     IPR001841 Znf_RING
     IPR016902 VPS41
     IPR017986 WD40_repeat_dom
     IPR013083 Znf_RING/FYVE/PHD

    Graphical View of Domain Structure for InterPro Entry P49754

    ProtoNet protein and cluster: P49754

    1 Blocks protein domain: IPB001841 Zn-finger

    UniProtKB/Swiss-Prot: VPS41_HUMAN, P49754
    Similarity: Belongs to the VPS41 family
    Similarity: Contains 1 CHCR (clathrin heavy-chain) repeat
    Similarity: Contains 1 RING-type zinc finger


    VPS41 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: VPS41_HUMAN, P49754
    Function: Required for vacuolar assembly and vacuolar traffic

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0005488binding ----
    GO:0005515protein binding IPI19109425
    GO:0008017microtubule binding IEA--
    GO:0008270zinc ion binding IEA--
         
    VPS41 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for VPS41:
     Increased G1 DNA content 

         4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Vps41):
     cellular  embryogenesis  mortality/aging  normal 

    VPS41 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Vps41tm1.1Ywd for VPS41

       inGenious Targeting Laboratory - Custom generated mouse model solutions for VPS41 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for VPS41

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for VPS41 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for VPS41 

    miRNA
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    8/14 QIAGEN miScript miRNA Assays for microRNAs that regulate VPS41 (see all 14):
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    SwitchGear 3'UTR luciferase reporter plasmidVPS41 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VPS41


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for VPS41

    STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

    5/102 Interacting proteins for VPS41 (P497541, 2, 3 ENSP000003094574) via UniProtKB, MINT, STRING, and/or I2D (see all 102)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ZNF512BQ96KM62, 3MINT-60801 I2D: score=2 
    VIPAS39Q9H9C11, 3, ENSP000003391224EBI-2130459,EBI-749080 I2D: score=1 STRING: ENSP00000339122
    VPS16Q9H2693, ENSP000003698104I2D: score=4 STRING: ENSP00000369810
    VPS18Q9P2533, ENSP000002205094I2D: score=4 STRING: ENSP00000220509
    AP3D1O146173, ENSP000003440554I2D: score=2 STRING: ENSP00000344055
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006886intracellular protein transport IEA--
    GO:0008150biological_process ND--
    GO:0016192vesicle-mediated transport IEA--
    GO:0048193Golgi vesicle transport IMP11412045

    VPS41 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for VPS41

    Search CenterWatch for drugs/clinical trials and news about VPS41

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for VPS41 gene (2 alternative transcripts): 
    NM_014396.3  NM_080631.3  

    Unigene Cluster for VPS41:

    Vacuolar protein sorting 41 homolog (S. cerevisiae)
    Hs.592184  [show with all ESTs]
    Unigene Representative Sequence: BX648347
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000310301(uc003tgx.3 uc003tgy.3 uc003tgz.3 uc010kxn.3)
    ENST00000395969 ENST00000490924 ENST00000448833 ENST00000482217 ENST00000439468
    ENST00000462429 ENST00000466017 ENST00000485955 ENST00000413141 ENST00000265745
    ENST00000414632 ENST00000418457 ENST00000457055

    miRNA
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    8/14 QIAGEN miScript miRNA Assays for microRNAs that regulate VPS41 (see all 14):
    hsa-miR-4324 hsa-miR-610 hsa-miR-922 hsa-miR-7-2* hsa-miR-3065-5p hsa-miR-216b hsa-miR-132 hsa-miR-888*
    SwitchGear 3'UTR luciferase reporter plasmidVPS41 3' UTR sequence
    Inhib. RNA
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    Sirion Biotech Customized lentivirus for stable overexpression of VPS41 
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat VPS41

    Additional mRNA sequence: 

    AK026848.1 AK074325.1 AK299143.1 AK314556.1 BC044851.1 BX648347.1 L40398.1 U87281.1 
    U87309.1 

    12 DOTS entries:

    DT.117027  DT.95370258  DT.100812755  DT.95370251  DT.100812754  DT.100778421  DT.92014699  DT.100812758 
    DT.121039289  DT.423593  DT.92027483  DT.432241 

    24/236 AceView cDNA sequences (see all 236):

    BM973529 AA648315 CB046463 AA536081 R08855 BC044851 BU625848 BE901432 
    BM995616 AW080257 CD676095 AI493112 AI204672 AU127158 AI679635 BM666111 
    CR618313 AA782361 NM_014396 BU685928 BX451885 BU616977 CB050919 BX451884 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for VPS41 (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^
    SP1:                                                                                -                       -                                                   
    SP2:                                -                                               -                       -                                                   
    SP3:                                                  -     -                       -                       -                                                   
    SP4:                                                                                                                                                            
    SP5:                                                                                -                                                                           

    ExUns: 23 ^ 24a · 24b ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31a · 31b
    SP1:        -                                   -                     
    SP2:        -                                   -                     
    SP3:        -                                   -                     
    SP4:                                                                  
    SP5:                                                                  


    ECgene alternative splicing isoforms for VPS41

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    VPS41 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCGGACACTC
    VPS41 Expression
    About this image


    See VPS41 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for VPS41

    SOURCE GeneReport for Unigene cluster: Hs.592184
        SABiosciences Expression via Pathway-Focused PCR Array including VPS41: 
              Ubiquitin Ligases in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VPS41

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for VPS41 gene from 9/19 species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Vps411 , 5 vacuolar protein sorting 41 (yeast)1, 5 90.93(n)1
    97.3(a)1
      13 (6.75 cM)5
    2180351  NM_172120.41  NP_742118.31 
     187172925 
    chicken
    (Gallus gallus)
    Aves VPS411 vacuolar protein sorting 41 homolog (S. cerevisiae) 83.08(n)
    92.16(a)
      420762  NM_001012859.1  NP_001012877.1 
    lizard
    (Anolis carolinensis)
    Reptilia VPS416
    vacuolar protein sorting 41 homolog (S. cerevisiae...
    89(a)
    1 ↔ 1
    6(48028572-48180735)
    zebrafish
    (Danio rerio)
    Actinopterygii wufa01f112 wufa01f11 76.05(n)   334731  57076493 
    fruit fly
    (Drosophila melanogaster)
    Insecta lt1 , 3 ommochrome biosynthesis3
    light1
    37(a)3
    48.75(n)1
    39.47(a)1
      23
    33551301  NM_001042951.11  NP_001036416.11 
    worm
    (Caenorhabditis elegans)
    Secernentea F32A6.33   -- 27(a)   X(5320762-5324817)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes VPS41(YDR080W)4 Vacuolar membrane protein that is a subunit of the more   --   4(604008-606986) 851653  NP_010365.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons VPS411 vacuolar protein sorting-associated protein 41-like more 48.59(n)
    40.34(a)
      837340  NM_100693.3  NP_172297.2 
    rice
    (Oryza sativa)
    Liliopsida Os04g01950001 hypothetical protein 49.9(n)
    40.69(a)
      4335134  NM_001058748.1  NP_001052213.1 


    ENSEMBL Gene Tree for VPS41 (if available)
    TreeFam Gene Tree for VPS41 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for VPS41 gene
    1 SIMAP similar gene for VPS41 using alignment to 12 protein entries:     VPS41_HUMAN (see all proteins):
    HVPS41

    VPS41 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3659 SNPs in VPS41 are shown (see all 3659)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs32072551,2
    C,F,A--38763060(-) GGCGTA/GAGTCA 2 -- ds500110Minor allele frequency- G:0.44MN NA WA CSA EA 552
    rs1477310341,2
    --38763099(+) GTGGGC/TGGATT 2 -- ds50010--------
    rs1165760321,2
    F--38763207(+) TACTCC/TCACCT 2 -- ds50011Minor allele frequency- T:0.01WA 118
    rs733707301,2
    C--38763217(+) TACTCC/TGGAAG 2 -- ds50014Minor allele frequency- T:0.11WA CSA NA 241
    rs177001421,2
    C,F,H--38763391(+) GTTCTT/CCCCCA 2 -- ds500121Minor allele frequency- C:0.28NA NS EA WA 2476
    rs177677701,2
    C,F--38763577(+) AAAAGA/TCATTC 2 -- ut31 trp310Minor allele frequency- T:0.35NA EA WA CSA 579
    rs745243491,2
    C,F--38763590(+) AGGAAC/TGAAAG 2 -- ut313Minor allele frequency- T:0.13WA CSA 122
    rs1884879911,2
    --38763614(+) TTAACA/GATAAA 2 -- ut310--------
    rs1813488491,2
    --38763630(+) TATTGC/TTCAGG 2 -- ut310--------
    rs733707361,2
    C,F--38763753(+) CTATAA/GGTAGG 2 -- ut313Minor allele frequency- G:0.13WA CSA 122

    HapMap Linkage Disequilibrium report for VPS41 (38762563 - 38971994 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for VPS41:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv830967CNV Loss17160897
    nsv887966CNV Loss21882294
    nsv887965CNV Gain21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605485    OMIM disorders: --

    2 diseases for VPS41:    About MalaCards
    alzheimer's disease    parkinson's disease


    VPS41 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): VPS41
    Human Genome Epidemiology (HuGE) Navigator: VPS41 (2 documents)

    Export disorders for VPS41 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for VPS41 gene, integrated from 9 sources (see all 29):
    (articles sorted by number of sources associating them with VPS41)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of VPS41, a gene required for vacuolar trafficking and high-affinity iron transport in yeast. (PubMed id 9159129)1, 2, 3 Radisky D.C.... Kaplan J. (1997)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    3. A genome-wide study of common SNPs and CNVs in cognit ive performance in the CANTAB. (PubMed id 19734545)1, 4 Need A.C....Goldstein D.B. (2009)
    4. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (2003)
    5. Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease. (PubMed id 7596406)1, 2 Sherrington R....Holman K. (1995)
    6. hVps41 and VAMP7 function in direct TGN to late endoso me transport of lysosomal membrane proteins. (PubMed id 23322049)1 Pols M.S....Klumperman J. (2013)
    7. The HOPS proteins hVps41 and hVps39 are required for h omotypic and heterotypic late endosome fusion. (PubMed id 23167963)1 Pols M.S....Klumperman J. (2013)
    8. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    9. Quantitative analysis of HSP90-client interactions rev eals principles of substrate recognition. (PubMed id 22939624)1 Taipale M....Lindquist S. (2012)
    10. Functional analysis of VPS41-mediated neuroprotection in Caenorhabditis elegans and mammalian models of Parkinson's disease. (PubMed id 22323726)1 Harrington A.J....Caldwell G.A. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 27072 HGNC: 12713 AceView: VPS41 Ensembl:ENSG00000006715 euGenes: HUgn27072
    ECgene: VPS41 H-InvDB: VPS41

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for VPS41 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for VPS41 gene:
    Search GeneIP for patents involving VPS41

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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