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VPS41 Gene

protein-coding   GIFtS: 58
GCID: GC07M039370

Vacuolar Protein Sorting 41 Homolog (S. Cerevisiae)

(Previous names: vacuolar protein sorting 41 (yeast homolog), vacuolar protein...)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Vacuolar Protein Sorting 41 Homolog (S. Cerevisiae)1 2     HVSP412
S532 3     hVps41p2
Vacuolar Protein Sorting 41 (Yeast Homolog)1     Vacuolar Assembly Protein 412
Vacuolar Protein Sorting 41 (Yeast)1     Vacuolar Protein Sorting-Associated Protein 41 Homolog2
HVPS412     

External Ids:    HGNC: 127131   Entrez Gene: 270722   Ensembl: ENSG000000067157   OMIM: 6054855   UniProtKB: P497543   

Export aliases for VPS41 gene to outside databases

Previous GC identifers: GC07M038409 GC07M038470 GC07M038504 GC07M038536 GC07M038730 GC07M038913 GC07M039137


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for VPS41 Gene:
Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct
organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved
in vesicle transport to vacuoles. This gene encodes the human ortholog of yeast Vps41 protein which is also
conserved in Drosophila, tomato, and Arabidopsis. Expression studies in yeast and human indicate that this
protein may be involved in the formation and fusion of transport vesicles from the Golgi. Several transcript
variants encoding different isoforms have been described for this gene, however, the full-length nature of not
all is known. (provided by RefSeq, Jul 2008)

GeneCards Summary for VPS41 Gene:
VPS41 (vacuolar protein sorting 41 homolog (S. cerevisiae)) is a protein-coding gene. GO annotations related to this gene include microtubule binding.

UniProtKB/Swiss-Prot: VPS41_HUMAN, P49754
Function: Required for vacuolar assembly and vacuolar traffic




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NC_018918.2  NT_007819.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the VPS41 gene promoter:
         USF1   STAT1   GATA-3   AML1a   GATA-1   GATA-2   FAC1   SREBP-1a   USF-1   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 5): VPS41 promoter sequence
   Search Chromatin IP Primers for VPS41

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat VPS41


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p14-p13   Ensembl cytogenetic band:  7p14.1   HGNC cytogenetic band: 7p14.1-p13

VPS41 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
VPS41 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M039370:  view genomic region     (about GC identifiers)

Start:
38,762,563 bp from pter      End:
38,971,994 bp from pter
Size:
209,432 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 38,801,230-38,986,499     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: VPS41_HUMAN, P49754 (See protein sequence)
Recommended Name: Vacuolar protein sorting-associated protein 41 homolog  
Size: 854 amino acids; 98566 Da
Secondary accessions: Q86TP8 Q99851 Q99852
Alternative splicing: 2 isoforms:  P49754-1   P49754-2   

Explore the universe of human proteins at neXtProt for VPS41: NX_P49754

Explore proteomics data for VPS41 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys762
  • Modification sites at PhosphoSitePlus

  • See VPS41 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_055211.2  NP_542198.2  

    ENSEMBL proteins: 
     ENSP00000309457   ENSP00000379297   ENSP00000391980   ENSP00000395410   ENSP00000412974  
     ENSP00000265745   ENSP00000411919   ENSP00000407835   ENSP00000398584  

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    Novus Biologicals VPS41 Proteins
    Novus Biologicals VPS41 Lysates
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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for VPS41

     
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    antibodies-online proteins for VPS41 (4 products) 

     
    antibodies-online peptides for VPS41

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 7):
     IPR011990 TPR-like_helical
     IPR001841 Znf_RING
     IPR013083 Znf_RING/FYVE/PHD
     IPR000547 Clathrin_H-chain/VPS_repeat
     IPR016902 VPS41

    Graphical View of Domain Structure for InterPro Entry P49754

    ProtoNet protein and cluster: P49754

    1 Blocks protein domain: IPB001841 Zn-finger

    UniProtKB/Swiss-Prot: VPS41_HUMAN, P49754
    Similarity: Belongs to the VPS41 family
    Similarity: Contains 1 CHCR (clathrin heavy-chain) repeat
    Similarity: Contains 1 RING-type zinc finger


    Find genes that share domains with VPS41           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: VPS41_HUMAN, P49754
    Function: Required for vacuolar assembly and vacuolar traffic

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0005488binding ----
    GO:0005515protein binding IPI19109425
    GO:0008017microtubule binding IEA--
    GO:0008270zinc ion binding IEA--
         
    Find genes that share ontologies with VPS41           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for VPS41:
     Increased G1 DNA content 

         4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Vps41):
     cellular  embryogenesis  mortality/aging  normal 

    Find genes that share phenotypes with VPS41           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Vps41tm1.1Ywd for VPS41

       genOway: Develop your customized and physiologically relevant rodent model for VPS41

    miRNA
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    miRTarBase miRNAs that target VPS41:
    hsa-mir-148a-3p (MIRT048028), hsa-let-7b-5p (MIRT052120)

    Block miRNA regulation of human, mouse, rat VPS41 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate VPS41 (see all 14):
    hsa-miR-4324 hsa-miR-610 hsa-miR-922 hsa-miR-7-2* hsa-miR-3065-5p hsa-miR-216b hsa-miR-132 hsa-miR-888*
    SwitchGear 3'UTR luciferase reporter plasmidVPS41 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for VPS41
    Predesigned siRNA for gene silencing in human, mouse, rat VPS41

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 2): VPS41 (NM_014396)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for VPS41
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VPS41

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VPS41


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    vacuole5
    golgi apparatus4
    cytoskeleton2
    endosome2
    lysosome2
    mitochondrion2
    nucleus2

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005765lysosomal membrane IDA17897319
    GO:0005769early endosome IEA--
    GO:0005770late endosome IEA--
    GO:0005798Golgi-associated vesicle IMP11412045
    GO:0005829cytosol IDA11412045

    Find genes that share ontologies with VPS41           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Array including VPS41: 
              Ubiquitin Ligases in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for VPS41

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for VPS41 (P497541, 2, 3 ENSP000003094574) via UniProtKB, MINT, STRING, and/or I2D (see all 180)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ZNF512BQ96KM62, 3MINT-60801 I2D: score=2 
    VIPAS39Q9H9C11, 3, ENSP000003391224EBI-2130459,EBI-749080 I2D: score=1 STRING: ENSP00000339122
    VPS16Q9H2693, ENSP000003698104I2D: score=4 STRING: ENSP00000369810
    VPS18Q9P2533, ENSP000002205094I2D: score=4 STRING: ENSP00000220509
    AP3D1O146173, ENSP000003440554I2D: score=2 STRING: ENSP00000344055
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006886intracellular protein transport IEA--
    GO:0008150biological_process ND--
    GO:0016192vesicle-mediated transport IEA--
    GO:0048193Golgi vesicle transport IMP11412045

    Find genes that share ontologies with VPS41           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for VPS41



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for VPS41 gene (2 alternative transcripts): 
    NM_014396.3  NM_080631.3  

    Unigene Cluster for VPS41:

    Vacuolar protein sorting 41 homolog (S. cerevisiae)
    Hs.592184  [show with all ESTs]
    Unigene Representative Sequence: BX648347
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000310301(uc003tgx.3 uc003tgy.3 uc003tgz.3 uc010kxn.3)
    ENST00000395969 ENST00000490924 ENST00000448833 ENST00000482217 ENST00000439468
    ENST00000462429 ENST00000466017 ENST00000485955 ENST00000413141 ENST00000265745
    ENST00000414632 ENST00000418457 ENST00000457055
    miRNA
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    Block miRNA regulation of human, mouse, rat VPS41 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate VPS41 (see all 14):
    hsa-miR-4324 hsa-miR-610 hsa-miR-922 hsa-miR-7-2* hsa-miR-3065-5p hsa-miR-216b hsa-miR-132 hsa-miR-888*
    SwitchGear 3'UTR luciferase reporter plasmidVPS41 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for VPS41
    Predesigned siRNA for gene silencing in human, mouse, rat VPS41
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    OriGene ORF clones in mouse, rat for VPS41
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    GenScript: all cDNA clones in your preferred vector (see all 2): VPS41 (NM_014396)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for VPS41
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VPS41
    Primer
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    OriGene qPCR primer pairs and template standards for VPS41
    OriGene qSTAR qPCR primer pairs in human, mouse for VPS41
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat VPS41
      QuantiTect SYBR Green Assays in human, mouse, rat VPS41
      QuantiFast Probe-based Assays in human, mouse, rat VPS41

    Additional mRNA sequence: 

    AK026848.1 AK074325.1 AK299143.1 AK314556.1 BC044851.1 BX648347.1 L40398.1 U87281.1 
    U87309.1 

    12 DOTS entries:

    DT.117027  DT.95370258  DT.100812755  DT.95370251  DT.100812754  DT.100778421  DT.92014699  DT.100812758 
    DT.121039289  DT.423593  DT.92027483  DT.432241 

    Selected AceView cDNA sequences (see all 236):

    CR618313 CA413123 BF726982 AV654315 N67365 AA747720 BX324550 AA782361 
    NM_014396 BU616977 BX324551 AI927638 BX451885 AL120542 CA419715 AU139291 
    AU125612 CD676095 BM995616 AI955961 U87281 BX451884 NM_080631 BM463541 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for VPS41 (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^
    SP1:                                                                                -                       -                                                   
    SP2:                                -                                               -                       -                                                   
    SP3:                                                  -     -                       -                       -                                                   
    SP4:                                                                                                                                                            
    SP5:                                                                                -                                                                           

    ExUns: 23 ^ 24a · 24b ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31a · 31b
    SP1:        -                                   -                     
    SP2:        -                                   -                     
    SP3:        -                                   -                     
    SP4:                                                                  
    SP5:                                                                  


    ECgene alternative splicing isoforms for VPS41

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    VPS41 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCGGACACTC
    VPS41 Expression
    About this image


    VPS41 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Brain (Nervous System)
             Cerebral Cortex
    VPS41 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    VPS41 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.592184
        Pathway & Disease-focused RT2 Profiler PCR Array including VPS41: 
              Ubiquitin Ligases in human mouse rat

    Primer
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    OriGene qPCR primer pairs and template standards for VPS41
    OriGene qSTAR qPCR primer pairs in human, mouse for VPS41
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat VPS41
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    QuantiFast Probe-based Assays in human, mouse, rat VPS41
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VPS41

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for VPS41 gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Vps411 , 5 vacuolar protein sorting 41 (yeast)1, 5 90.11(n)1
    96.37(a)1
      13 (6.75 cM)5
    2180351  NM_172120.41  NP_742118.31 
     187172925 
    chicken
    (Gallus gallus)
    Aves VPS411 vacuolar protein sorting 41 homolog (S. cerevisiae) 83.08(n)
    92.16(a)
      420762  NM_001012859.1  NP_001012877.1 
    lizard
    (Anolis carolinensis)
    Reptilia VPS416
    vacuolar protein sorting 41 homolog (S. cerevisiae...
    89(a)
    1 ↔ 1
    6(48028572-48180735)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia vps411 vacuolar protein sorting 41 homolog (S. cerevisiae) 74.43(n)
    80.8(a)
      100489726  XM_004912520.1  XP_004912577.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufa01f112 wufa01f11 76.05(n)   334731  57076493 
    fruit fly
    (Drosophila melanogaster)
    Insecta lt1 , 3 ommochrome biosynthesis3
    light1
    37(a)3
    49.22(n)1
    39.72(a)1
      23
    33551301  NM_001273766.11  NP_001260695.11 
    worm
    (Caenorhabditis elegans)
    Secernentea F32A6.33   -- 27(a)   X(5320762-5324817)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes VPS41(YDR080W)4 Vacuolar membrane protein that is a subunit of the more   --   4(604008-606986) 851653  NP_010365.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons VPS411 VPS41 48.65(n)
    39.97(a)
      837340  NM_100693.3  NP_172297.2 
    rice
    (Oryza sativa)
    Liliopsida Os04g01950001 Os04g0195000 50.06(n)
    40.64(a)
      4335134  NM_001058748.1  NP_001052213.1 


    ENSEMBL Gene Tree for VPS41 (if available)
    TreeFam Gene Tree for VPS41 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for VPS41 gene
    1 SIMAP similar gene for VPS41 using alignment to 12 protein entries:     VPS41_HUMAN (see all proteins):
    HVPS41

    Find genes that share paralogs with VPS41           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for VPS41 (see all 3659)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs32072551,2
    C,F,A--38763060(-) GGCGTA/GAGTCA 2 -- ds500110Minor allele frequency- G:0.44MN NA WA CSA EA 552
    rs1477310341,2
    --38763099(+) GTGGGC/TGGATT 2 -- ds50010--------
    rs1165760321,2
    F--38763207(+) TACTCC/TCACCT 2 -- ds50011Minor allele frequency- T:0.01WA 118
    rs733707301,2
    C--38763217(+) TACTCC/TGGAAG 2 -- ds50014Minor allele frequency- T:0.11WA CSA NA 241
    rs177001421,2
    C,F,H--38763391(+) GTTCTT/CCCCCA 2 -- ds500121Minor allele frequency- C:0.28NA NS EA WA 2476
    rs177677701,2
    C,F--38763577(+) AAAAGA/TCATTC 2 -- ut31 trp310Minor allele frequency- T:0.35NA EA WA CSA 579
    rs745243491,2
    C,F--38763590(+) AGGAAC/TGAAAG 2 -- ut313Minor allele frequency- T:0.13WA CSA 122
    rs1884879911,2
    --38763614(+) TTAACA/GATAAA 2 -- ut310--------
    rs1813488491,2
    --38763630(+) TATTGC/TTCAGG 2 -- ut310--------
    rs733707361,2
    C,F--38763753(+) CTATAA/GGTAGG 2 -- ut313Minor allele frequency- G:0.13WA CSA 122

    HapMap Linkage Disequilibrium report for VPS41 (38762563 - 38971994 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for VPS41:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv830967CNV Loss17160897
    nsv887966CNV Loss21882294
    nsv887965CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing VPS41
    DNA2.0 Custom Variant and Variant Library Synthesis for VPS41

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605485    OMIM disorders: --


    Find genes that share disorders with VPS41           About GenesLikeMe

    Genetic Association Database (GAD): VPS41
    Human Genome Epidemiology (HuGE) Navigator: VPS41 (2 documents)

    Export disorders for VPS41 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for VPS41 gene, integrated from 10 sources (see all 29):
    (articles sorted by number of sources associating them with VPS41)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of VPS41, a gene required for vacuolar trafficking and high-affinity iron transport in yeast. (PubMed id 9159129)1, 2, 3 Radisky D.C.... Kaplan J. (Proc. Natl. Acad. Sci. U.S.A. 1997)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB. (PubMed id 19734545)1, 4 Need A.C....Goldstein D.B. (Hum. Mol. Genet. 2009)
    4. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (Nature 2003)
    5. Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease. (PubMed id 7596406)1, 2 Sherrington R....St George-Hyslop P.H. (Nature 1995)
    6. hVps41 and VAMP7 function in direct TGN to late endosome transport of lysosomal membrane proteins. (PubMed id 23322049)1 Pols M.S....Klumperman J. (Nat Commun 2013)
    7. The HOPS proteins hVps41 and hVps39 are required for homotypic and heterotypic late endosome fusion. (PubMed id 23167963)1 Pols M.S....Klumperman J. (Traffic 2013)
    8. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    9. Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. (PubMed id 22939624)1 Taipale M....Lindquist S. (Cell 2012)
    10. Functional analysis of VPS41-mediated neuroprotection in Caenorhabditis elegans and mammalian models of Parkinson's disease. (PubMed id 22323726)1 Harrington A.J....Caldwell G.A. (J. Neurosci. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 27072 HGNC: 12713 AceView: VPS41 Ensembl:ENSG00000006715 euGenes: HUgn27072
    ECgene: VPS41 H-InvDB: VPS41

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for VPS41 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for VPS41 gene:
    Search GeneIP for patents involving VPS41

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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