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Aliases for VPS41 Gene

Aliases for VPS41 Gene

  • Vacuolar Protein Sorting 41 Homolog (S. Cerevisiae) 2 3
  • S53 3 4
  • Vacuolar Protein Sorting-Associated Protein 41 Homolog 3
  • Vacuolar Protein Sorting 41 (Yeast Homolog) 2
  • Vacuolar Protein Sorting 41 (Yeast) 2
  • Vacuolar Assembly Protein 41 3
  • HVps41p 3
  • HVPS41 3
  • HVSP41 3

External Ids for VPS41 Gene

Previous GeneCards Identifiers for VPS41 Gene

  • GC07M038409
  • GC07M038470
  • GC07M038504
  • GC07M038536
  • GC07M038913
  • GC07M039137
  • GC07M039370

Summaries for VPS41 Gene

Entrez Gene Summary for VPS41 Gene

  • Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene encodes the human ortholog of yeast Vps41 protein which is also conserved in Drosophila, tomato, and Arabidopsis. Expression studies in yeast and human indicate that this protein may be involved in the formation and fusion of transport vesicles from the Golgi. Several transcript variants encoding different isoforms have been described for this gene, however, the full-length nature of not all is known. [provided by RefSeq, Jul 2008]

GeneCards Summary for VPS41 Gene

VPS41 (Vacuolar Protein Sorting 41 Homolog (S. Cerevisiae)) is a Protein Coding gene. GO annotations related to this gene include microtubule binding.

UniProtKB/Swiss-Prot for VPS41 Gene

  • Required for vacuolar assembly and vacuolar traffic.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VPS41 Gene

Genomics for VPS41 Gene

Regulatory Elements for VPS41 Gene

Genomic Location for VPS41 Gene

38,722,963 bp from pter
38,932,394 bp from pter
209,432 bases
Minus strand

Genomic View for VPS41 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for VPS41 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VPS41 Gene

Proteins for VPS41 Gene

  • Protein details for VPS41 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Vacuolar protein sorting-associated protein 41 homolog
    Protein Accession:
    Secondary Accessions:
    • E9PF36
    • Q86TP8
    • Q99851
    • Q99852

    Protein attributes for VPS41 Gene

    854 amino acids
    Molecular mass:
    98566 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for VPS41 Gene


neXtProt entry for VPS41 Gene

Proteomics data for VPS41 Gene at MOPED

Post-translational modifications for VPS41 Gene

  • Ubiquitination at Lys762
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for VPS41 Gene

Domains for VPS41 Gene

Suggested Antigen Peptide Sequences for VPS41 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • P49754
  • Belongs to the VPS41 family.
  • Contains 1 CHCR (clathrin heavy-chain) repeat.
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with VPS41: view

No data available for Gene Families for VPS41 Gene

Function for VPS41 Gene

Molecular function for VPS41 Gene

UniProtKB/Swiss-Prot Function:
Required for vacuolar assembly and vacuolar traffic.

Gene Ontology (GO) - Molecular Function for VPS41 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005488 binding --
GO:0005515 protein binding IPI 19109425
GO:0008017 microtubule binding IEA --
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with VPS41: view

Phenotypes for VPS41 Gene

genes like me logo Genes that share phenotypes with VPS41: view

Animal Models for VPS41 Gene

MGI Knock Outs for VPS41:

Animal Model Products

miRNA for VPS41 Gene

miRTarBase miRNAs that target VPS41

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for VPS41 Gene

Localization for VPS41 Gene

Subcellular locations from

Jensen Localization Image for VPS41 Gene COMPARTMENTS Subcellular localization image for VPS41 gene
Compartment Confidence
cytosol 5
vacuole 5
golgi apparatus 4
cytoskeleton 2
endosome 2
lysosome 2
mitochondrion 2
nucleus 2

Gene Ontology (GO) - Cellular Components for VPS41 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005765 lysosomal membrane IDA 17897319
GO:0005769 early endosome IEA --
GO:0005770 late endosome IBA --
GO:0005798 Golgi-associated vesicle IMP 11412045
GO:0005829 cytosol IDA 11412045
genes like me logo Genes that share ontologies with VPS41: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for VPS41 Gene

Pathways for VPS41 Gene

SuperPathways for VPS41 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for VPS41 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006623 protein targeting to vacuole IBA --
GO:0006886 intracellular protein transport --
GO:0008150 biological_process ND --
GO:0016192 vesicle-mediated transport IEA --
GO:0035542 regulation of SNARE complex assembly IBA --
genes like me logo Genes that share ontologies with VPS41: view

No data available for Pathways by source for VPS41 Gene

Transcripts for VPS41 Gene

Unigene Clusters for VPS41 Gene

Vacuolar protein sorting 41 homolog (S. cerevisiae):
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for VPS41

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for VPS41 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^
SP1: - -
SP2: - - -
SP3: - - - -
SP5: -

ExUns: 23 ^ 24a · 24b ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31a · 31b
SP1: - -
SP2: - -
SP3: - -

Relevant External Links for VPS41 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for VPS41 Gene

mRNA expression in normal human tissues for VPS41 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for VPS41 Gene

This gene is overexpressed in Bone (13.2), Peripheral blood mononuclear cells (7.8), Lymph node (7.6), and Monocytes (6.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for VPS41 Gene

SOURCE GeneReport for Unigene cluster for VPS41 Gene Hs.592184

genes like me logo Genes that share expressions with VPS41: view

Expression partners for VPS41 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for VPS41 Gene

Orthologs for VPS41 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for VPS41 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia VPS41 35
  • 92.7 (n)
  • 97.66 (a)
VPS41 36
  • 98 (a)
(Canis familiaris)
Mammalia VPS41 35
  • 93.51 (n)
  • 97.82 (a)
VPS41 36
  • 98 (a)
(Mus musculus)
Mammalia Vps41 35
  • 90.11 (n)
  • 96.37 (a)
Vps41 16
Vps41 36
  • 97 (a)
(Pan troglodytes)
Mammalia VPS41 35
  • 99.69 (n)
  • 100 (a)
VPS41 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Vps41 35
  • 90.05 (n)
  • 95.97 (a)
(Monodelphis domestica)
Mammalia VPS41 36
  • 86 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 86 (a)
-- 36
  • 90 (a)
(Gallus gallus)
Aves VPS41 35
  • 83.08 (n)
  • 92.16 (a)
VPS41 36
  • 92 (a)
(Anolis carolinensis)
Reptilia VPS41 36
  • 89 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia vps41 35
  • 74.43 (n)
  • 80.8 (a)
(Danio rerio)
Actinopterygii vps41 35
  • 72.6 (n)
  • 82.2 (a)
wufa01f11 35
vps41 36
  • 82 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12328 35
fruit fly
(Drosophila melanogaster)
Insecta lt 37
  • 37 (a)
lt 35
  • 49.22 (n)
  • 39.72 (a)
lt 36
  • 36 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009174 35
  • 49.33 (n)
  • 41.12 (a)
(Caenorhabditis elegans)
Secernentea F32A6.3 37
  • 27 (a)
vps-41 36
  • 26 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes VPS41 36
  • 21 (a)
VPS41 38
thale cress
(Arabidopsis thaliana)
eudicotyledons VPS41 35
  • 48.65 (n)
  • 39.97 (a)
(Oryza sativa)
Liliopsida Os04g0195000 35
  • 50.06 (n)
  • 40.64 (a)
Species with no ortholog for VPS41:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for VPS41 Gene

Gene Tree for VPS41 (if available)
Gene Tree for VPS41 (if available)

Paralogs for VPS41 Gene

genes like me logo Genes that share paralogs with VPS41: view

No data available for Paralogs for VPS41 Gene

Variants for VPS41 Gene

Sequence variations from dbSNP and Humsavar for VPS41 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs13251 -- 38,725,965(-) GTCTA(A/G)GAGTT utr-variant-3-prime
rs37472 -- 38,817,151(-) AGAAA(A/G)TCTCT intron-variant
rs37473 -- 38,816,037(-) CTAAA(A/C)ACTTT intron-variant
rs37474 -- 38,814,593(-) GGCTC(A/G)CTGCA intron-variant
rs37475 -- 38,811,537(-) TATTT(A/T)AAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for VPS41 Gene

Variant ID Type Subtype PubMed ID
nsv887965 CNV Gain 21882294
nsv887966 CNV Loss 21882294
nsv830967 CNV Loss 17160897

Relevant External Links for VPS41 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VPS41 Gene

Disorders for VPS41 Gene

Relevant External Links for VPS41

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for VPS41 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for VPS41 Gene

Publications for VPS41 Gene

  1. Characterization of VPS41, a gene required for vacuolar trafficking and high-affinity iron transport in yeast. (PMID: 9159129) Radisky D.C. … Kaplan J. (Proc. Natl. Acad. Sci. U.S.A. 1997) 2 3 4
  2. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 3 4
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  4. A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB. (PMID: 19734545) Need A.C. … Goldstein D.B. (Hum. Mol. Genet. 2009) 3 48
  5. Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease. (PMID: 7596406) Sherrington R. … St George-Hyslop P.H. (Nature 1995) 3 4

Products for VPS41 Gene

Sources for VPS41 Gene

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