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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

VPS39 Gene

protein-coding   GIFtS: 57
GCID: GC15M042450

vacuolar protein sorting 39 homolog (S. cerevisiae)

(Previous name: vacuolar protein sorting 39 (yeast) )
 Explore 4 diseases affiliated with
VPS39 via our new
 Human Malady Compendium 
Biological research products
for VPS39
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Vacuolar Protein Sorting 39 Homolog (S. Cerevisiae)1 2     HVam6p1
VAM61 2 3 5     TRAP1-Like Protein2 3
KIAA07701 3 5     Vacuolar Protein Sorting 39 (Yeast)1
TLP2 3 5     Vam6/Vps39-Like Protein2

External Ids:    HGNC: 205931   Entrez Gene: 233392   Ensembl: ENSG000001668877   OMIM: 6121885   UniProtKB: Q96JC13   

Export aliases for VPS39 gene to outside databases

Previous GC identifers: GC15M037818 GC15M035346 GC15M040030 GC15M040166 GC15M040238 GC15M019299


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for VPS39:
This gene encodes a protein that may promote clustering and fusion of late endosomes and lysosomes. The protein may
also act as an adaptor protein that modulates the transforming growth factor-beta response by coupling the
transforming growth factor-beta receptor complex to the Smad pathway. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: VPS39_HUMAN, Q96JC1
Function: May play a role in clustering and fusion of late endosomes and lysosomes. Regulator of TGF-beta/activin
signaling, inhibiting SMAD3- and activating SMAD2-dependent transcription. Acts by interfering with SMAD3/SMAD4
complex formation, this would lead to inhibition of SMAD3-dependent transcription and relieve SMAD3 inhibition of
SMAD2-dependent promoters, thus increasing SMAD2-dependent transcription. Does not affect TGF-beta-induced SMAD2 or
SMAD3 phosphorylation, nor SMAD2/SMAD4 complex formation

Gene Wiki entry for VPS39


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NC_018926.1  NT_010194.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the VPS39 gene promoter:
         RP58   AML1a   HTF   RORalpha2   c-Ets-1   FOXJ2 (long isoform)   FOXO1a   FOXJ2   En-1   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidVPS39 promoter sequence
   Search SABiosciences Chromatin IP Primers for VPS39

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat VPS39


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q15.1   Ensembl cytogenetic band:  15q15.1   HGNC cytogenetic band: 15q14

VPS39 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
VPS39 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M042450:  view genomic region     (about GC identifiers)

Start:
42,450,899 bp from pter      End:
42,500,514 bp from pter
Size:
49,616 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: VPS39_HUMAN, Q96JC1 (See protein sequence)
Recommended Name: Vam6/Vps39-like protein  
Size: 886 amino acids; 101809 Da
Subunit: Homooligomer. Interacts with TGFBR2 and, less efficiently, with TGFBR1; interaction with TGFBR2 is independent
of the receptor kinase activity and of the presence of TGF-beta. Also interacts with ACVR2B, but not with BMPR2.
Interacts with SMAD4, preferentially following TGF-beta treatment. Does not interact with SAMD2 or SMAD3
Subcellular location: Cytoplasm. Lysosome membrane; Peripheral membrane protein. Late endosome membrane; Peripheral
membrane protein. Note=Colocalizes with TGFBR1 and TGFBR2 in cytoplasmic vesicular structures and most prominently in
cortical vesicles
Sequence caution: Sequence=BAA34490.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: O94869 Q71SQ6 Q7Z3V3 Q96B93 Q96RM0
Alternative splicing: 2 isoforms:  Q96JC1-1   Q96JC1-2   

Explore the universe of human proteins at neXtProt for VPS39: NX_Q96JC1

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q96JC1

  • VPS39 Protein expression data from MOPED and PaxDb:    About this image 
    VPS39 Protein Expression
    REFSEQ proteins: NP_056104.2  
    ENSEMBL proteins: 
     ENSP00000326534   ENSP00000457325   ENSP00000335193  

    Human Recombinant Protein Products for VPS39: 
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    Uscn Proteins for VPS39

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005765lysosomal membrane IEA--
    GO:0030897HOPS complex IDA19109425
    GO:0031902late endosome membrane IEA--

    VPS39 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    VPS39 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR001180 Citron
     IPR019452 VPS39/TGF_beta_rcpt-assoc_1
     IPR019453 VPS39/TGF_beta_rcpt-assoc_2

    Graphical View of Domain Structure for InterPro Entry Q96JC1

    ProtoNet protein and cluster: Q96JC1

    1 Blocks protein family: IPB001180 Citron-like

    UniProtKB/Swiss-Prot: VPS39_HUMAN, Q96JC1
    Similarity: Belongs to the VAM6/VPS39 family
    Similarity: Contains 1 CNH domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: VPS39_HUMAN, Q96JC1
    Function: May play a role in clustering and fusion of late endosomes and lysosomes. Regulator of TGF-beta/activin
    signaling, inhibiting SMAD3- and activating SMAD2-dependent transcription. Acts by interfering with SMAD3/SMAD4
    complex formation, this would lead to inhibition of SMAD3-dependent transcription and relieve SMAD3 inhibition of
    SMAD2-dependent promoters, thus increasing SMAD2-dependent transcription. Does not affect TGF-beta-induced SMAD2 or
    SMAD3 phosphorylation, nor SMAD2/SMAD4 complex formation

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005083small GTPase regulator activity IEA--
    GO:0005515protein binding ----
         
    VPS39 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for VPS39:
     Decreased Salmonella enterica   Decreased Salmonella enterica   Decreased Salmonella-containin 

    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for VPS39 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VPS39


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for VPS39

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    5/18 Interacting proteins for VPS39 (Q96JC13 ENSP000003265344) via UniProtKB, MINT, STRING, and/or I2D (see all 18)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HOOK1Q9UJC33, ENSP000003602524I2D: score=1 STRING: ENSP00000360252
    ADSSL1Q8N1423I2D: score=5 
    EEF1GP266413I2D: score=5 
    RPS14P622633I2D: score=5 
    RPS4XP627013I2D: score=5 
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0015031protein transport IEA--

    VPS39 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for VPS39
    Search CenterWatch for drugs/clinical trials and news about VPS39 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for VPS39 gene: 
    NM_015289.2  

    Unigene Cluster for VPS39:

    Vacuolar protein sorting 39 homolog (S. cerevisiae)
    Hs.88025  [show with all ESTs]
    Unigene Representative Sequence: NM_015289
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000318006(uc001zpc.3 uc001zpd.3) ENST00000562258(uc001zpb.3)
    ENST00000564994 ENST00000348544 ENST00000568755 ENST00000562662 ENST00000561818
    ENST00000561797 ENST00000563692 ENST00000568029 ENST00000570023 ENST00000570062
    ENST00000568357

    miRNA
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    8/21 QIAGEN miScript miRNA Assays for microRNAs that regulate VPS39 (see all 21):
    hsa-miR-320a hsa-miR-3128 hsa-miR-330-5p hsa-miR-1285 hsa-miR-216b hsa-miR-223 hsa-miR-4314 hsa-miR-320e
    SwitchGear 3'UTR luciferase reporter plasmidVPS39 3' UTR sequence
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat VPS39
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    Additional cDNA sequence: 

    AB018313.2 AF280814.1 AF281052.1 AK025334.1 AK074193.1 AK124199.1 AK124255.1 AK128403.1 
    AL117456.1 BC015817.2 BC068559.1 BX537404.1 

    20 DOTS entries:

    DT.100796762  DT.95072706  DT.95198033  DT.216995  DT.100657283  DT.100796761  DT.100796765  DT.40291455 
    DT.95133276  DT.92442075  DT.95364610  DT.102826932  DT.121036801  DT.95196286  DT.97795505  DT.100710352 
    DT.95198022  DT.95310451  DT.95362132  DT.97782360 

    24/341 AceView cDNA sequences (see all 341):

    CK429487 CA442841 AW150613 BC015817 CB215900 AI017435 BQ001263 AI433765 
    AA365197 AW131048 CD517206 BQ772045 BX480756 BM972655 BE905660 BM907903 
    AI902816 AA862578 BE262313 BU623748 AF281052 AA894712 BG819686 CF143792 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for VPS39 (see all 7)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19a · 19b ^ 20a · 20b ^ 21 ^
    SP1:                    -                                   -                                                                       -                 -         
    SP2:                                                                                                                                                  -         
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 22a · 22b ^ 23a · 23b ^ 24a · 24b ^ 25a · 25b
    SP1:  -                                             
    SP2:  -                                             
    SP3:                                                
    SP4:                                                
    SP5:                                                


    ECgene alternative splicing isoforms for VPS39

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    VPS39 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CTCCCAAGCT
    VPS39 Expression
    About this image
    See VPS39 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for VPS39

    SOURCE GeneReport for Unigene cluster: Hs.88025

    UniProtKB/Swiss-Prot: VPS39_HUMAN, Q96JC1
    Tissue specificity: Widely expressed, with highest levels in heart, skeletal muscle, kidney, pancreas, brain, placenta
    and spleen

        SABiosciences Custom PCR Arrays for VPS39
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VPS39

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for VPS39 gene from 8/28 species (see all 28)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Vps391 , 5 vacuolar protein sorting 39 (yeast)1, 5 91.05(n)1
    97.26(a)1
      2 (60.31 cM)5
    2693381  NM_147153.31  NP_671495.11 
     1203164615 
    chicken
    (Gallus gallus)
    Aves VPS391 vacuolar protein sorting 39 homolog (S. cerevisiae) 82.06(n)
    93.94(a)
      423230  NM_001031194.1  NP_001026365.1 
    lizard
    (Anolis carolinensis)
    Reptilia VPS396
    --
    91(a)
    1 ↔ 1
    1(40045973-40078654)
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.187002 Transcribed sequence with weak similarity to protein more 79.61(n)    BQ480977.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG71461 , 3 CG71461 35(a)3
    49.52(n)1
    39.13(a)1
      90F113
    421921  NM_142445.11  NP_650702.11 
    worm
    (Caenorhabditis elegans)
    Secernentea T08G5.53
    vps-391
    Protein VPS-391 30(a)3
    43.65(n)1
    33.41(a)1
      V(14037190-14040946)3
    1799021  NM_001129538.11  NP_001123010.11 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons EMB27541 Vacuolar sorting protein 39 44.75(n)
    31.75(a)
      829815  NM_119826.7  NP_195381.6 
    rice
    (Oryza sativa)
    Liliopsida Os03g07155001 hypothetical protein 43.6(n)
    32.27(a)
      4333909  NM_001057612.1  NP_001051077.1 


    ENSEMBL Gene Tree for VPS39 (if available)
    TreeFam Gene Tree for VPS39 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for VPS39 gene
    TGFBRAP12  

    VPS39 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/840 NCBI SNPs in VPS39 are shown (see all 840    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs784841891,2
    C,F--42450538(+) TGGCCA/GAAGTG 3 -- us2k1 ds50011Minor allele frequency- G:0.02WA 118
    rs1920238621,2
    --42450681(+) TGTCCC/TGCAGA 3 -- ds5001 us2k10--------
    rs1850028751,2
    --42450682(+) GTCCCA/GCAGAA 3 -- ds5001 us2k10--------
    rs1496839561,2
    --42450714(+) CCGTAC/TCTGTG 3 -- ds5001 us2k10--------
    rs1455249791,2
    --42450729(+) TGACTA/CATCAG 3 -- ds5001 us2k10--------
    rs1123539381,2
    C--42450747(+) CACACC/TGNNNN 3 -- ds5001 us2k10--------
    rs1878118171,2
    --42450758(+) TACCAC/TGTGGC 3 -- ds5001 us2k10--------
    rs1425175251,2
    --42450777(+) TGCAAA/GTATTA 3 -- us2k1 ds50010--------
    rs1151258331,2
    --42450900(+) CAGATA/TGGCTT 1 -- ut311Minor allele frequency- T:0.01WA 118
    rs1476364481,2
    --42450920(+) CTTTAC/TTAGGT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for VPS39 (42450899 - 42500514 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for VPS39
         2 CNVs: 30708 0785

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing VPS39
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    VPS39 for disorders           About GeneDecksing

    OMIM gene information: 612188    OMIM disorders: --

    4 diseases for VPS39:    About MalaCards
    chediak-higashi syndrome    hermansky-pudlak syndrome    merkel cell carcinoma    carcinoma

    1 disease from the University of Copenhagen DISEASES database for VPS39:
    ARC syndrome
    Human Genome Epidemiology (HuGE) Navigator: VPS39 (3 documents)

    Export disorders for VPS39 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for VPS39 gene, integrated from 9 sources (see all 25):
    (articles sorted by number of sources associating them with VPS39)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human Vam6p promotes lysosome clustering and fusion in vivo. (PubMed id 11448994)1, 2, 3, 9 Caplan S.... Bonifacino J.S. (2001)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. TLP, a novel modulator of TGF-beta signaling, has opposite effects on Smad2- and Smad3-dependent signaling. (PubMed id 12941698)1, 2 Felici A....Roberts A.B. (2003)
    4. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)1, 2 Nakajima D.... Nagase T. (2002)
    5. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 9872452)1, 2 Nagase T.... Ohara O. (1998)
    6. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    7. NOTCH1 nuclear interactome reveals key regulators of i ts transcriptional activity and oncogenic function. (PubMed id 23022380)1 Yatim A....Benkirane M. (2012)
    8. An important role for CDK2 in G1 to S checkpoint activation and DNA damage response in human embryonic stem cells. (PubMed id 21319273)1 Neganova I....Lako M. (2011)
    9. Merkel cell polyomavirus large T antigen disrupts lys osome clustering by translocating human Vam6p from the cytoplasm to the nucleus . (PubMed id 21454559)1 Liu X....Chang Y. (2011)
    10. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23339 HGNC: 20593 AceView: VPS39 Ensembl:ENSG00000166887 euGenes: HUgn23339
    ECgene: VPS39 H-InvDB: VPS39

    (According to HUGE)
    About This Section
    HUGE: KIAA0770

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for VPS39 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for VPS39 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for VPS39 gene:
    Search GeneIP for patents involving VPS39

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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