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VPS39 Gene

protein-coding   GIFtS: 60
GCID: GC15M042450

Vacuolar Protein Sorting 39 Homolog (S. Cerevisiae)

(Previous name: vacuolar protein sorting 39 (yeast))
  See VPS39-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Vacuolar Protein Sorting 39 Homolog (S. Cerevisiae)1 2     TRAP1-Like Protein2 3
TLP2 3 5     KIAA07703 5
VAM62 3 5     Vacuolar Protein Sorting 39 (Yeast)1
hVam6p2 3     Vam6/Vps39-Like Protein2

External Ids:    HGNC: 205931   Entrez Gene: 233392   Ensembl: ENSG000001668877   OMIM: 6121885   UniProtKB: Q96JC13   

Export aliases for VPS39 gene to outside databases

Previous GC identifers: GC15M037818 GC15M035346 GC15M040030 GC15M040166 GC15M040238 GC15M019299


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for VPS39 Gene:
This gene encodes a protein that may promote clustering and fusion of late endosomes and lysosomes. The protein
may also act as an adaptor protein that modulates the transforming growth factor-beta response by coupling the
transforming growth factor-beta receptor complex to the Smad pathway. (provided by RefSeq, Jul 2008)

GeneCards Summary for VPS39 Gene:
VPS39 (vacuolar protein sorting 39 homolog (S. cerevisiae)) is a protein-coding gene. Diseases associated with VPS39 include arc syndrome. GO annotations related to this gene include small GTPase regulator activity. An important paralog of this gene is TGFBRAP1.

UniProtKB/Swiss-Prot: VPS39_HUMAN, Q96JC1
Function: May play a role in clustering and fusion of late endosomes and lysosomes. Regulator of TGF-beta/activin
signaling, inhibiting SMAD3- and activating SMAD2-dependent transcription. Acts by interfering with SMAD3/SMAD4
complex formation, this would lead to inhibition of SMAD3-dependent transcription and relieve SMAD3 inhibition of
SMAD2-dependent promoters, thus increasing SMAD2-dependent transcription. Does not affect TGF-beta-induced SMAD2
or SMAD3 phosphorylation, nor SMAD2/SMAD4 complex formation

Gene Wiki entry for VPS39 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000015.9  NT_010194.18  NC_018926.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the VPS39 gene promoter:
         RP58   AML1a   HTF   RORalpha2   c-Ets-1   FOXJ2 (long isoform)   FOXO1a   FOXJ2   En-1   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidVPS39 promoter sequence
   Search Chromatin IP Primers for VPS39

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat VPS39


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q15.1   Ensembl cytogenetic band:  15q15.1   HGNC cytogenetic band: 15q14

VPS39 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
VPS39 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M042450:  view genomic region     (about GC identifiers)

Start:
42,450,899 bp from pter      End:
42,500,514 bp from pter
Size:
49,616 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: VPS39_HUMAN, Q96JC1 (See protein sequence)
Recommended Name: Vam6/Vps39-like protein  
Size: 886 amino acids; 101809 Da
Subunit: Homooligomer. Interacts with TGFBR2 and, less efficiently, with TGFBR1; interaction with TGFBR2 is
independent of the receptor kinase activity and of the presence of TGF-beta. Also interacts with ACVR2B, but not
with BMPR2. Interacts with SMAD4, preferentially following TGF-beta treatment. Does not interact with SAMD2 or
SMAD3
Sequence caution: Sequence=BAA34490.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: O94869 Q71SQ6 Q7Z3V3 Q96B93 Q96RM0
Alternative splicing: 2 isoforms:  Q96JC1-1   Q96JC1-2   

Explore the universe of human proteins at neXtProt for VPS39: NX_Q96JC1

Explore proteomics data for VPS39 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys843
  • Modification sites at PhosphoSitePlus

  • See VPS39 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_056104.2  
    ENSEMBL proteins: 
     ENSP00000326534   ENSP00000457325   ENSP00000335193  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR000547 Clathrin_H-chain/VPS_repeat
     IPR001180 Citron
     IPR019452 VPS39/TGF_beta_rcpt-assoc_1
     IPR019453 VPS39/TGF_beta_rcpt-assoc_2

    Graphical View of Domain Structure for InterPro Entry Q96JC1

    ProtoNet protein and cluster: Q96JC1

    1 Blocks protein domain: IPB001180 Citron-like

    UniProtKB/Swiss-Prot: VPS39_HUMAN, Q96JC1
    Similarity: Belongs to the VAM6/VPS39 family
    Similarity: Contains 1 CHCR (clathrin heavy-chain) repeat
    Similarity: Contains 1 CNH domain


    Find genes that share domains with VPS39           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: VPS39_HUMAN, Q96JC1
    Function: May play a role in clustering and fusion of late endosomes and lysosomes. Regulator of TGF-beta/activin
    signaling, inhibiting SMAD3- and activating SMAD2-dependent transcription. Acts by interfering with SMAD3/SMAD4
    complex formation, this would lead to inhibition of SMAD3-dependent transcription and relieve SMAD3 inhibition of
    SMAD2-dependent promoters, thus increasing SMAD2-dependent transcription. Does not affect TGF-beta-induced SMAD2
    or SMAD3 phosphorylation, nor SMAD2/SMAD4 complex formation

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005083small GTPase regulator activity IEA--
    GO:0005515protein binding ----
         
    Find genes that share ontologies with VPS39           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for VPS39:
     Decreased Salmonella enterica   Decreased Salmonella enterica   Decreased Salmonella-containin 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for VPS39

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    hsa-let-7b-5p (MIRT001579), hsa-mir-335-5p (MIRT017323), hsa-mir-425-5p (MIRT039334)

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    VPS39_HUMAN, Q96JC1: Cytoplasm. Lysosome membrane; Peripheral membrane protein. Late endosome membrane;
    Peripheral membrane protein. Note=Colocalizes with TGFBR1 and TGFBR2 in cytoplasmic vesicular structures and most
    prominently in cortical vesicles
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endosome5
    lysosome5
    vacuole5
    cytosol2
    nucleus2
    golgi apparatus1
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005765lysosomal membrane IDA17897319
    GO:0030897HOPS complex IDA19109425
    GO:0031902late endosome membrane IEA--

    Find genes that share ontologies with VPS39           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for VPS39
    Interactions:

        Search GeneGlobe Interaction Network for VPS39

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for VPS39 (Q96JC13 ENSP000003265344) via UniProtKB, MINT, STRING, and/or I2D (see all 81)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HOOK1Q9UJC33, ENSP000003602524I2D: score=1 STRING: ENSP00000360252
    ADSSL1Q8N1423I2D: score=5 
    EEF1GP266413I2D: score=5 
    RPS14P622633I2D: score=5 
    RPS4XP627013I2D: score=5 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006886intracellular protein transport IEA--
    GO:0016192vesicle-mediated transport IEA--

    Find genes that share ontologies with VPS39           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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      Browse compounds at ApexBio 

    Browse Tocris compounds for VPS39



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for VPS39 gene: 
    NM_015289.2  

    Unigene Cluster for VPS39:

    Vacuolar protein sorting 39 homolog (S. cerevisiae)
    Hs.88025  [show with all ESTs]
    Unigene Representative Sequence: NM_015289
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000318006(uc001zpc.3 uc001zpd.3) ENST00000562258(uc001zpb.3)
    ENST00000564994 ENST00000348544 ENST00000568755 ENST00000562662 ENST00000561818
    ENST00000561797 ENST00000563692 ENST00000568029 ENST00000570023 ENST00000570062
    ENST00000568357
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    hsa-miR-320a hsa-miR-3128 hsa-miR-330-5p hsa-miR-1285 hsa-miR-216b hsa-miR-223 hsa-miR-4314 hsa-miR-320e
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      QuantiFast Probe-based Assays in human, mouse, rat VPS39

    Additional mRNA sequence: 

    AB018313.2 AF280814.1 AF281052.1 AK025334.1 AK074193.1 AK124199.1 AK124255.1 AK128403.1 
    AL117456.1 BC015817.2 BC068559.1 BX537404.1 

    20 DOTS entries:

    DT.100796762  DT.95072706  DT.95198033  DT.216995  DT.100657283  DT.100796761  DT.100796765  DT.40291455 
    DT.95133276  DT.92442075  DT.95364610  DT.102826932  DT.121036801  DT.95196286  DT.97795505  DT.100710352 
    DT.95198022  DT.95310451  DT.95362132  DT.97782360 

    Selected AceView cDNA sequences (see all 341):

    T36205 BC015817 CD671286 BI254388 Z38486 BE906439 AA583684 CF143792 
    CA442841 CF137145 AI348264 AW150613 AL524221 BE905660 BE859070 BQ001263 
    AA678699 AK124255 AL117456 BQ882750 AI433765 AA365197 CA443823 AW591581 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for VPS39 (see all 7)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19a · 19b ^ 20a · 20b ^ 21 ^
    SP1:                    -                                   -                                                                       -                 -         
    SP2:                                                                                                                                                  -         
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 22a · 22b ^ 23a · 23b ^ 24a · 24b ^ 25a · 25b
    SP1:  -                                             
    SP2:  -                                             
    SP3:                                                
    SP4:                                                
    SP5:                                                


    ECgene alternative splicing isoforms for VPS39

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    VPS39 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTCCCAAGCT
    VPS39 Expression
    About this image

    VPS39 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    VPS39 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.88025

    UniProtKB/Swiss-Prot: VPS39_HUMAN, Q96JC1
    Tissue specificity: Widely expressed, with highest levels in heart, skeletal muscle, kidney, pancreas, brain,
    placenta and spleen

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VPS39

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for VPS39 gene from Selected species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Vps391 , 5 vacuolar protein sorting 39 (yeast)1, 5 91.05(n)1
    97.26(a)1
      2 (60.31 cM)5
    2693381  NM_147153.31  NP_671495.11 
     1203164615 
    chicken
    (Gallus gallus)
    Aves VPS391 vacuolar protein sorting 39 homolog (S. cerevisiae) 82.06(n)
    93.94(a)
      423230  NM_001031194.1  NP_001026365.1 
    lizard
    (Anolis carolinensis)
    Reptilia VPS396
    vacuolar protein sorting 39 homolog (S. cerevisiae...
    93(a)
    1 ↔ 1
    1(40045688-40081235)
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.187002 Transcribed sequence with weak similarity to protein more 79.61(n)    BQ480977.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG71461 , 3 CG71461 35(a)3
    49.48(n)1
    38.98(a)1
      90F113
    421921  NM_142445.11  NP_650702.11 
    worm
    (Caenorhabditis elegans)
    Secernentea T08G5.53
    vps-391
    vps-391 30(a)3
    43.92(n)1
    34(a)1
      V(14037190-14040946)3
    1799021  NM_001047698.21  NP_001041163.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes VAM6(YDL077C)4 Vacuolar protein that plays a critical role in the more   --   4(320120-316971) 851482  NP_010206.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons EMB27541 EMB2754 44.67(n)
    31.64(a)
      829815  NM_119826.7  NP_195381.6 
    rice
    (Oryza sativa)
    Liliopsida Os03g07155001 Os03g0715500 44.54(n)
    33.5(a)
      4333909  NM_001057612.1  NP_001051077.1 


    ENSEMBL Gene Tree for VPS39 (if available)
    TreeFam Gene Tree for VPS39 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for VPS39 gene
    TGFBRAP12  

    Find genes that share paralogs with VPS39           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for VPS39 (see all 997)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1151258331,2
    F--42450900(+) CAGATA/TGGCTT 1 -- ut311Minor allele frequency- T:0.01WA 118
    rs1476364481,2
    C--42450920(+) CTTTAC/TTAGGT 1 -- ut310--------
    rs1915852381,2
    --42450964(+) GTCCTC/TACTAC 1 -- ut310--------
    rs1423154231,2
    C--42450969(+) CACTAA/CAAAGC 1 -- ut310--------
    rs70861,2
    C,F,O,A,H--42451108(+) TCAAAG/CACAGT 1 -- ut3130Minor allele frequency- C:0.31MN NS EA WA NA CA CSAM 3725
    rs1844574151,2
    C--42451117(+) GTTTGC/TGAGAA 1 -- ut310--------
    rs1140750341,2
    C,F--42451178(+) TCAAGT/ATCCTG 1 -- ut311Minor allele frequency- A:0.04WA 118
    rs10442191,2
    C,F,H--42451204(-) AAGCTC/TTGGGC 1 -- ut314Minor allele frequency- T:0.01NS NA 354
    rs31771411,2
    C--42451250(-) CTCATC/TTGGGC 1 -- ut312Minor allele frequency- T:0.00MN NA 186
    rs1889831161,2
    C--42451304(+) CGTGGC/TGCCAC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for VPS39 (42450899 - 42500514 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for VPS39:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv1507CNV Insertion18451855
    nsv832985CNV Loss17160897
    nsv9245CNV Gain18304495
    nsv471683CNV Gain+Loss15918152

    Human Gene Mutation Database (HGMD): VPS39
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing VPS39
    DNA2.0 Custom Variant and Variant Library Synthesis for VPS39

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 612188    OMIM disorders: --

    1 disease for VPS39:    
    About MalaCards
    arc syndrome

    1 disease from the University of Copenhagen DISEASES database for VPS39:
    ARC syndrome

    Find genes that share disorders with VPS39           About GenesLikeMe

    Genetic Association Database (GAD): VPS39
    Human Genome Epidemiology (HuGE) Navigator: VPS39 (3 documents)

    Export disorders for VPS39 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for VPS39 gene, integrated from 10 sources (see all 27):
    (articles sorted by number of sources associating them with VPS39)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human Vam6p promotes lysosome clustering and fusion in vivo. (PubMed id 11448994)1, 2, 3, 9 Caplan S.... Bonifacino J.S. (J. Cell Biol. 2001)
    2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    3. Integral and associated lysosomal membrane proteins. (PubMed id 17897319)1, 2 Schroeder B.... Hasilik A. (Traffic 2007)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. TLP, a novel modulator of TGF-beta signaling, has opposite effects on Smad2- and Smad3-dependent signaling. (PubMed id 12941698)1, 2 Felici A.... Roberts A.B. (EMBO J. 2003)
    6. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)1, 2 Nakajima D.... Nagase T. (DNA Res. 2002)
    7. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 9872452)1, 2 Nagase T.... Ohara O. (DNA Res. 1998)
    8. Effects of TRAP-1-like protein (TLP) gene on collagen synthesis induced by TGF-I^/Smad signaling in human dermal fibroblasts. (PubMed id 23418473)1 Wang X....Wang D. (PLoS ONE 2013)
    9. The HOPS proteins hVps41 and hVps39 are required for homotypic and heterotypic late endosome fusion. (PubMed id 23167963)1 Pols M.S....Klumperman J. (Traffic 2013)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 23339 HGNC: 20593 AceView: VPS39 Ensembl:ENSG00000166887 euGenes: HUgn23339
    ECgene: VPS39 H-InvDB: VPS39

    (According to HUGE)
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    HUGE: KIAA0770

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for VPS39 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for VPS39 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for VPS39 gene:
    Search GeneIP for patents involving VPS39

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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