VPS37D Gene
protein-coding GIFtS: 49
GCID: GC07P073082
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|
vacuolar protein sorting 37 homolog D (S. cerevisiae)(Previous names: Williams Beuren syndrome chromosome region 24, vacuolar...)
(Previous symbol: WBSCR24)
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Aliases
for VPS37D gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Vacuolar Protein Sorting 37 Homolog D (S. Cerevisiae)1 2 | | Vacuolar Protein Sorting 37D (Yeast)1 | | WBSCR241 2 3 5 | | Vacuolar Protein Sorting 37D2 | | Williams Beuren Syndrome Chromosome Region 241 2 | | Vacuolar Protein Sorting-Associated Protein 37D2 | | Williams-Beuren Syndrome Chromosomal Region 24 Protein2 3 | | Williams-Beuren Syndrome Critical Region Protein 242 | | ESCRT-I Complex Subunit VPS37D2 3 | | Williams-Beuren Syndrome Region Protein 242 | | MGC353521 | | |
Export aliases for VPS37D gene to outside databasesPrevious GC identifers: GC07P072507 GC07P072700 GC07P068964 |
Summaries
for VPS37D gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: VP37D_HUMAN, Q86XT2Function: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting ofendocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation
|
Genomic Views
for VPS37D gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000007.13 NC_018918.1 NT_007933.15 NT_079593.2
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for VPS37D
Other transcription factors
Search SABiosciences Chromatin IP Primers for VPS37D
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat VPS37D |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 7q11.23 Ensembl cytogenetic band: 7q11.23 HGNC cytogenetic band: 7q11.23VPS37D Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07P073082: view genomic region
(about GC identifiers)
Start:
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73,082,155 bp from pter |
End:
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73,086,442 bp from pter |
Size:
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4,288 bases |
Orientation:
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plus strand |
1 alternative location:
| Chr7+,CRA_TCAG 72,415,246-72,419,512 |
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Proteins
for VPS37D gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: VP37D_HUMAN, Q86XT2 (See
protein sequence)Recommended Name: Vacuolar protein sorting-associated protein 37D Size: 251 amino acids; 27730 Da
Subunit: Component of the ESCRT-I complex (endosomal sorting complex required for transport I) which consists ofTSG101, VPS28, a VPS37 protein (VPS37A to -D) and MVB12A or MVB12B in a 1:1:1:1 stoechiometry. Interacts with TSG101and MVB12A
Subcellular location: Late endosome membrane; Peripheral membrane protein (Probable)
Sequence caution: Sequence=AAL91075.1; Type=Erroneous initiation;
Secondary accessions: Q6P2C3Explore the universe of human proteins at neXtProt for VPS37D: NX_Q86XT2
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q86XT2
VPS37D Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001071089.1
ENSEMBL proteins: ENSP00000320416 ENSP00000413337 Reactome Protein details: Q86XT2
Human Recombinant Protein Products for VPS37D:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0010008 | endosome membrane |
TAS | -- | | GO:0031902 | late endosome membrane |
IEA | -- |
VPS37D for ontologies About GeneDecksing
VPS37D Antibody Products:
Assay Products for VPS37D: |
Protein
Domains /
Families
for VPS37D gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
VPS37D for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q86XT2ProtoNet protein and cluster: Q86XT2 UniProtKB/Swiss-Prot: VP37D_HUMAN, Q86XT2Similarity: Belongs to the VPS37 familySimilarity: Contains 1 VPS37 C-terminal domain |
Function
for VPS37D gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: VP37D_HUMAN, Q86XT2Function: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting ofendocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiationPhenotypes:
1 GenomeRNAi human phenotype for VPS37D:
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for VPS37D (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for VPS37D (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: VPS37D (NM_001077621) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for VPS37D | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VPS37D |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VPS37D |
|
Pathways & Interactions
for VPS37D gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Signal Transduction | | | 2 | Late Phase of HIV Life Cycle | | | 3 | HIV Infection | | | 4 | Disease | | | 5 | Membrane Trafficking | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5/9 
Reactome Pathways for VPS37D (see all 9)
1 
Kegg Pathway (Kegg details for VPS37D):
VPS37D for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for VPS37D
STRING Interaction
Network Preview (showing 5 interactants - click image to see 23)
5/23 Interacting proteins for VPS37D (Q86XT22, 3 ENSP000003204164) via UniProtKB, MINT, STRING, and/or I2D (see all 23)About this table
Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table
VPS37D for ontologies About GeneDecksing
|
Drugs & Compounds
for VPS37D gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for VPS37D
Search CenterWatch for drugs/clinical trials and news about VPS37D / VP37D
|
Transcripts
for VPS37D gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for VPS37D gene (2 alternative transcripts): NM_152560.1 NM_001077621.1 Unigene Cluster for VPS37D: Vacuolar protein sorting 37 homolog D (S. cerevisiae) Hs.647037 [show with all ESTs]Unigene Representative Sequence: BC0297302 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000324941(uc003tyr.3) ENST00000451519
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for VPS37D (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for VPS37D (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: VPS37D (NM_001077621) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for VPS37D | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VPS37D |
Additional cDNA sequence: AY081952.1 BC029730.1 BC064621.1 2 DOTS entries: DT.100018588 DT.95074989 24/38 AceView cDNA sequences (see all 38): BC064621 CR596679 CR594226 CB216590 AW449892 BU740849 BX108782 AL526252 BF593962 BC029730 BX410346 BM906293 AA862452 AI521163 AA913638 BI823566 AL526216 BM701148 AI696387 BE883379 BM725417 BQ954989 AY081952 AA913175
GeneLoc Exon Structure
|
Expression
for VPS37D gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| VPS37D expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTCCAGACCC
About this image
See VPS37D Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for VPS37D
SOURCE GeneReport for Unigene cluster: Hs.647037
SABiosciences Custom PCR Arrays for VPS37D
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for VPS37D
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat VPS37D | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat VPS37D | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat VPS37D | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VPS37D |
Orthologs
for VPS37D gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for VPS37D gene from 5/16 species (see all 16) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
LOC1008598791 |
vacuolar protein sorting-associated protein 37D-like |
68.07(n)
58.42(a) |
|
100859879 XM_003642373.1 XP_003642421.1 |
lizard
(Anolis carolinensis) |
Reptilia |
VPS37D6 |
-- |
47(a) |
1 ↔ 1 |
GL344691.1(17272-20740) |
zebrafish
(Danio rerio) |
Actinopterygii |
zgc:1539966 |
zgc:153996 |
23(a) |
1 → many |
1(45405387-45418016) |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG11156 |
-- |
24(a) |
1 → many |
3R(1051882-1053248) |
worm
(Caenorhabditis elegans) |
Secernentea |
vps-376 |
related to yeast Vacuolar Protein Sorting factor f... |
23(a) |
1 → many |
V(5592691-5593592) |
ENSEMBL Gene Tree for VPS37D (if available)
TreeFam Gene Tree for VPS37D (if available) |
Paralogs
for VPS37D gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for VPS37D gene
- VPS37B2 VPS37C2 VPS37A2
2 SIMAP similar genes for VPS37D using alignment to 2 protein entries: VP37D_HUMAN (see all proteins):VPS37C VPS37B
VPS37D for paralogs About GeneDecksing
|
Genomic Variants
for VPS37D gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 7 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for VPS37D (73082155 - 73086442 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for VPS37D: -- | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for VPS37D gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
VPS37D for disorders About GeneDecksing
OMIM gene information: 610039
OMIM disorders: --
UniProtKB/Swiss-Prot: VP37D_HUMAN, Q86XT2
Note=VPS37D is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygousdeletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over betweenhighly homologous low-copy repeat sequences flanking the deleted region
1  disease for VPS37D: About MalaCardswilliams-beuren syndrome
1 disease from the University of Copenhagen DISEASES database for VPS37D:Williams-Beuren syndrome Export disorders for VPS37D gene to outside databases
|
Publications
for VPS37D gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for VPS37D gene integrated from 9 sources:
(articles sorted by number of sources associating them with VPS37D) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The human endosomal sorting complex required for transport (ESCRT-I) and its role in HIV-1 budding. (PubMed id 15218037)1, 2, 3 Stuchell M.D....Sundquist W.I. (2004)
- Human ESCRT and ALIX proteins interact with proteins of the midbody and function in cytokinesis. (PubMed id 17853893)1 Morita E....Sundquist W.I. (2007)
- Identification of human MVB12 proteins as ESCRT-I subunits that function in HIV budding. (PubMed id 18005716)2 Morita E....Sundquist W.I. (2007)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- The DNA sequence of human chromosome 7. (PubMed id 12853948)2 Hillier L.W.... Wilson R.K. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
- Secretory protein trafficking and organelle dynamics in living cells. (PubMed id 11031247)1 Lippincott-Schwartz J....Hirschberg K. (2000)
|
External Searches for VPS37D gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing VPS37D gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing VPS37D gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing VPS37D gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for VPS37D | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for VPS37D gene:
Search GeneIP for patents involving VPS37D
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for VPS37D gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat VPS37D | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing VPS37D | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat VPS37D | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat VPS37D | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat VPS37D | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat VPS37D |
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| |  |  |  |  | | | | |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VPS37D |
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