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Aliases for VPS37D Gene

Aliases for VPS37D Gene

  • VPS37D, ESCRT-I Subunit 2 3
  • Williams-Beuren Syndrome Chromosomal Region 24 Protein 3 4
  • Vacuolar Protein Sorting 37 Homolog D (S. Cerevisiae) 2 5
  • Williams Beuren Syndrome Chromosome Region 24 2 3
  • ESCRT-I Complex Subunit VPS37D 3 4
  • WBSCR24 3 4
  • Williams-Beuren Syndrome Critical Region Protein 24 3
  • Williams-Beuren Syndrome Region Protein 24 3
  • Vacuolar Protein Sorting 37 Homolog D 3
  • Vacuolar Protein Sorting 37D (Yeast) 2
  • Vacuolar Protein Sorting 37D 3

External Ids for VPS37D Gene

Previous HGNC Symbols for VPS37D Gene

  • WBSCR24

Previous GeneCards Identifiers for VPS37D Gene

  • GC07P072507
  • GC07P072700
  • GC07P073082
  • GC07P068964

Summaries for VPS37D Gene

GeneCards Summary for VPS37D Gene

VPS37D (VPS37D, ESCRT-I Subunit) is a Protein Coding gene. Diseases associated with VPS37D include williams-beuren syndrome. Among its related pathways are HIV Life Cycle and Infectious disease. An important paralog of this gene is VPS37C.

UniProtKB/Swiss-Prot for VPS37D Gene

  • Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VPS37D Gene

Genomics for VPS37D Gene

Regulatory Elements for VPS37D Gene

Promoters for VPS37D Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around VPS37D on UCSC Golden Path with GeneCards custom track

Genomic Location for VPS37D Gene

Chromosome:
7
Start:
73,667,825 bp from pter
End:
73,672,112 bp from pter
Size:
4,288 bases
Orientation:
Plus strand

Genomic View for VPS37D Gene

Genes around VPS37D on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
VPS37D Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for VPS37D Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VPS37D Gene

Proteins for VPS37D Gene

  • Protein details for VPS37D Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86XT2-VP37D_HUMAN
    Recommended name:
    Vacuolar protein sorting-associated protein 37D
    Protein Accession:
    Q86XT2
    Secondary Accessions:
    • Q6P2C3

    Protein attributes for VPS37D Gene

    Size:
    251 amino acids
    Molecular mass:
    27730 Da
    Quaternary structure:
    • Component of the ESCRT-I complex (endosomal sorting complex required for transport I) which consists of TSG101, VPS28, a VPS37 protein (VPS37A to -D) and MVB12A or MVB12B in a 1:1:1:1 stoechiometry. Interacts with TSG101 and MVB12A. Component of the ESCRT-I complex (endosomal sorting complex required for transport I) which consists of TSG101, VPS28, a VPS37 protein (VPS37A to -D) and UBAP1 in a 1:1:1:1 stoechiometry.
    SequenceCaution:
    • Sequence=AAL91075.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for VPS37D Gene

Proteomics data for VPS37D Gene at MOPED

Post-translational modifications for VPS37D Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for VPS37D Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for VPS37D Gene

Domains & Families for VPS37D Gene

Gene Families for VPS37D Gene

Protein Domains for VPS37D Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for VPS37D Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86XT2

UniProtKB/Swiss-Prot:

VP37D_HUMAN :
  • Contains 1 VPS37 C-terminal domain.
  • Belongs to the VPS37 family.
Domain:
  • Contains 1 VPS37 C-terminal domain.
Family:
  • Belongs to the VPS37 family.
genes like me logo Genes that share domains with VPS37D: view

Function for VPS37D Gene

Molecular function for VPS37D Gene

UniProtKB/Swiss-Prot Function:
Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.
genes like me logo Genes that share phenotypes with VPS37D: view

Animal Models for VPS37D Gene

MGI Knock Outs for VPS37D:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for VPS37D Gene

Localization for VPS37D Gene

Subcellular locations from UniProtKB/Swiss-Prot for VPS37D Gene

Late endosome membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for VPS37D Gene COMPARTMENTS Subcellular localization image for VPS37D gene
Compartment Confidence
nucleus 2
cytosol 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for VPS37D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with VPS37D: view

Pathways & Interactions for VPS37D Gene

genes like me logo Genes that share pathways with VPS37D: view

Pathways by source for VPS37D Gene

1 KEGG pathway for VPS37D Gene

Interacting Proteins for VPS37D Gene

Gene Ontology (GO) - Biological Process for VPS37D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006914 autophagy TAS 20588296
GO:0016032 viral process TAS --
GO:0016197 endosomal transport TAS --
GO:0019058 viral life cycle TAS --
GO:0019068 virion assembly TAS --
genes like me logo Genes that share ontologies with VPS37D: view

No data available for SIGNOR curated interactions for VPS37D Gene

Drugs & Compounds for VPS37D Gene

No Compound Related Data Available

Transcripts for VPS37D Gene

mRNA/cDNA for VPS37D Gene

Unigene Clusters for VPS37D Gene

Vacuolar protein sorting 37 homolog D (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for VPS37D Gene

No ASD Table

Relevant External Links for VPS37D Gene

GeneLoc Exon Structure for
VPS37D
ECgene alternative splicing isoforms for
VPS37D

Expression for VPS37D Gene

mRNA expression in normal human tissues for VPS37D Gene

Protein differential expression in normal tissues from HIPED for VPS37D Gene

This gene is overexpressed in Urine (65.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for VPS37D Gene



SOURCE GeneReport for Unigene cluster for VPS37D Gene Hs.647037

genes like me logo Genes that share expression patterns with VPS37D: view

Protein tissue co-expression partners for VPS37D Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for VPS37D Gene

Orthologs for VPS37D Gene

This gene was present in the common ancestor of animals.

Orthologs for VPS37D Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia VPS37D 35
  • 92.43 (n)
  • 97.61 (a)
VPS37D 36
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia VPS37D 35
  • 94.29 (n)
  • 97.61 (a)
VPS37D 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Vps37d 35
  • 90.97 (n)
  • 96.02 (a)
Vps37d 16
Vps37d 36
  • 92 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia VPS37D 35
  • 99.47 (n)
  • 100 (a)
VPS37D 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Vps37d 35
  • 90.97 (n)
  • 96.02 (a)
oppossum
(Monodelphis domestica)
Mammalia VPS37D 36
  • 66 (a)
OneToOne
chicken
(Gallus gallus)
Aves VPS37D 35
  • 71.22 (n)
  • 63.35 (a)
VPS37D 36
  • 55 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia VPS37D 36
  • 46 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia vps37d 35
  • 55.49 (n)
  • 52.69 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC101884856 35
  • 49.73 (n)
  • 40.32 (a)
VPS37D 36
  • 33 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG1115 36
  • 28 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea vps-37 36
  • 22 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10674 36
  • 21 (a)
OneToMany
Species with no ortholog for VPS37D:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for VPS37D Gene

ENSEMBL:
Gene Tree for VPS37D (if available)
TreeFam:
Gene Tree for VPS37D (if available)

Paralogs for VPS37D Gene

Paralogs for VPS37D Gene

(2) SIMAP similar genes for VPS37D Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with VPS37D: view

Variants for VPS37D Gene

Sequence variations from dbSNP and Humsavar for VPS37D Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1109512 -- 73,672,535(+) TGATT(C/G)TGGAA downstream-variant-500B
rs960473 -- 73,670,983(-) TGGGA(A/G)AGGCA intron-variant
rs1987329 -- 73,667,308(-) TATTT(A/T)AAAAA upstream-variant-2KB
rs1880952 -- 73,666,305(+) GCCTA(A/G)CCCAG upstream-variant-2KB
rs2008920 -- 73,667,217(-) GCGGG(C/T)GGATC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for VPS37D Gene

Variant ID Type Subtype PubMed ID
dgv7325n71 CNV Loss 21882294
nsv831028 CNV Loss 17160897
nsv469841 CNV Complex 16826518
nsv888370 CNV Loss 21882294
nsv888371 CNV Loss 21882294

Variation tolerance for VPS37D Gene

Gene Damage Index Score: 0.88; 18.36% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for VPS37D Gene

HapMap Linkage Disequilibrium report
VPS37D

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VPS37D Gene

Disorders for VPS37D Gene

MalaCards: The human disease database

(1) MalaCards diseases for VPS37D Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
williams-beuren syndrome
  • fanconi schlesinger syndrome
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

VP37D_HUMAN
  • Note=VPS37D is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region.

Relevant External Links for VPS37D

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
VPS37D
genes like me logo Genes that share disorders with VPS37D: view

No data available for Genatlas for VPS37D Gene

Publications for VPS37D Gene

  1. The human endosomal sorting complex required for transport (ESCRT-I) and its role in HIV-1 budding. (PMID: 15218037) Stuchell M.D. … Sundquist W.I. (J. Biol. Chem. 2004) 2 3 4 67
  2. Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption. (PMID: 25288136) . … Chasman D.I. (Mol. Psychiatry 2015) 3
  3. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M. … Moll S. (J Proteomics 2013) 3
  4. Genomic study in Mexicans identifies a new locus for triglycerides and refines European lipid loci. (PMID: 23505323) Weissglas-Volkov D. … Pajukanta P. (J. Med. Genet. 2013) 3
  5. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. (PMID: 23533145) Principe S. … Drake R.R. (Proteomics 2013) 3

Products for VPS37D Gene

Sources for VPS37D Gene

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