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VPS37D Gene

protein-coding   GIFtS: 50
GCID: GC07P073082

Vacuolar Protein Sorting 37 Homolog D (S. Cerevisiae)

(Previous names: Williams Beuren syndrome chromosome region 24, vacuolar...)
(Previous symbol: WBSCR24)
  See VPS37D-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Vacuolar Protein Sorting 37 Homolog D (S. Cerevisiae)1 2     Vacuolar Protein Sorting 37D (Yeast)1
WBSCR241 2 3 5     Vacuolar Protein Sorting 37D2
Williams Beuren Syndrome Chromosome Region 241 2     Vacuolar Protein Sorting-Associated Protein 37D2
Williams-Beuren Syndrome Chromosomal Region 24 Protein2 3     Williams-Beuren Syndrome Critical Region Protein 242
ESCRT-I Complex Subunit VPS37D2 3     Williams-Beuren Syndrome Region Protein 242

External Ids:    HGNC: 182871   Entrez Gene: 1553822   Ensembl: ENSG000001764287   OMIM: 6100395   UniProtKB: Q86XT23   

Export aliases for VPS37D gene to outside databases

Previous GC identifers: GC07P072507 GC07P072700 GC07P068964


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for VPS37D Gene:
VPS37D (vacuolar protein sorting 37 homolog D (S. cerevisiae)) is a protein-coding gene. Diseases associated with VPS37D include sall4-related disorders, and williams-beuren syndrome. An important paralog of this gene is VPS37B.

UniProtKB/Swiss-Prot: VP37D_HUMAN, Q86XT2
Function: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting
of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NC_018918.2  NT_007933.16  
Regulatory elements:
   Search for regulatory transcription factor binding sites for VPS37D
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for VPS37D

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat VPS37D


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q11.23   Ensembl cytogenetic band:  7q11.23   HGNC cytogenetic band: 7q11.23

VPS37D Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
VPS37D gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P073082:  view genomic region     (about GC identifiers)

Start:
73,082,155 bp from pter      End:
73,086,442 bp from pter
Size:
4,288 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 72,415,246-72,419,512     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: VP37D_HUMAN, Q86XT2 (See protein sequence)
Recommended Name: Vacuolar protein sorting-associated protein 37D  
Size: 251 amino acids; 27730 Da
Subunit: Component of the ESCRT-I complex (endosomal sorting complex required for transport I) which consists of
TSG101, VPS28, a VPS37 protein (VPS37A to -D) and MVB12A or MVB12B in a 1:1:1:1 stoechiometry. Interacts with
TSG101 and MVB12A. Component of the ESCRT-I complex (endosomal sorting complex required for transport I) which
consists of TSG101, VPS28, a VPS37 protein (VPS37A to -D) and UBAP1 in a 1:1:1:1 stoechiometry
Sequence caution: Sequence=AAL91075.1; Type=Erroneous initiation;
Secondary accessions: Q6P2C3

Explore the universe of human proteins at neXtProt for VPS37D: NX_Q86XT2

Explore proteomics data for VPS37D at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See VPS37D Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001071089.1  
    ENSEMBL proteins: 
     ENSP00000320416   ENSP00000413337  
    Reactome Protein details: Q86XT2

    VPS37D Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for VPS37D

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR009851 Mod_r

    Graphical View of Domain Structure for InterPro Entry Q86XT2

    ProtoNet protein and cluster: Q86XT2

    UniProtKB/Swiss-Prot: VP37D_HUMAN, Q86XT2
    Similarity: Belongs to the VPS37 family
    Similarity: Contains 1 VPS37 C-terminal domain


    Find genes that share domains with VPS37D           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: VP37D_HUMAN, Q86XT2
    Function: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting
    of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation

    Phenotypes:
         1 GenomeRNAi human phenotype for VPS37D:

     Decreased viability of wild-ty 

         1 MGI phenotypic allele for Vps37d (no phenotypes)

    Find genes that share phenotypes with VPS37D           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for VPS37D
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for VPS37D

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for VPS37D
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for VPS37D

    miRNA
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    miRTarBase miRNAs that target VPS37D:
    hsa-mir-375 (MIRT020000)

    Block miRNA regulation of human, mouse, rat VPS37D using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate VPS37D (see all 39):
    hsa-miR-194* hsa-miR-765 hsa-miR-449a hsa-miR-4267 hsa-miR-548m hsa-miR-3613-3p hsa-miR-23a hsa-miR-296-5p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    Gene Editing
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    VP37D_HUMAN, Q86XT2: Late endosome membrane; Peripheral membrane protein (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endosome5
    nucleus2
    cytosol1
    mitochondrion1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000813ESCRT I complex IDA--
    GO:0010008endosome membrane TAS--
    GO:0031902late endosome membrane IEA--
    GO:0070062extracellular vesicular exosome IDA19056867

    Find genes that share ontologies with VPS37D           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for VPS37D About    
    See pathways by source

    SuperPathContained pathways About
    1HIV Life Cycle
    HIV Life Cycle0.91
    Membrane binding and targetting of GAG proteins0.00
    Late Phase of HIV Life Cycle0.91
    Assembly Of The HIV Virion0.00
    HIV Infection0.62
    2Budding and maturation of HIV virion
    Budding and maturation of HIV virion0.64
    Endosomal Sorting Complex Required For Transport (ESCRT)0.64
    3Clathrin derived vesicle budding
    Membrane Trafficking0.32
    4Endocytosis
    Endocytosis
    5Disease
    Disease


    Find genes that share SuperPaths with VPS37D           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 Reactome Pathways for VPS37D
        Budding and maturation of HIV virion
    Membrane binding and targetting of GAG proteins
    Endosomal Sorting Complex Required For Transport (ESCRT)


    1 Kegg Pathway  (Kegg details for VPS37D):
        Endocytosis

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for VPS37D
    Interactions:

        Search GeneGlobe Interaction Network for VPS37D

    STRING Interaction Network Preview (showing 5 interactants - click image to see 24)

    Selected Interacting proteins for VPS37D (Q86XT22, 3 ENSP000003204164) via UniProtKB, MINT, STRING, and/or I2D (see all 24)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CEP55Q53EZ42, 3, ENSP000003605404MINT-6173476 I2D: score=2 STRING: ENSP00000360540
    TSG101Q998163, ENSP000002519684I2D: score=1 STRING: ENSP00000251968
    HGSO149643, ENSP000003312014I2D: score=1 STRING: ENSP00000331201
    CHMP2BENSP000002637804STRING: ENSP00000263780
    CHMP3ENSP000002638564STRING: ENSP00000263856
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0015031protein transport IEA--
    GO:0016032viral process TAS--
    GO:0016197endosomal transport TAS--
    GO:0019058viral life cycle TAS--
    GO:0019068virion assembly TAS--

    Find genes that share ontologies with VPS37D           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for VPS37D (VP37D)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for VPS37D gene (2 alternative transcripts): 
    NM_152560.1  NM_001077621.1  

    Unigene Cluster for VPS37D:

    Vacuolar protein sorting 37 homolog D (S. cerevisiae)
    Hs.647037  [show with all ESTs]
    Unigene Representative Sequence: BC029730
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000324941(uc003tyr.3) ENST00000451519
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat VPS37D using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate VPS37D (see all 39):
    hsa-miR-194* hsa-miR-765 hsa-miR-449a hsa-miR-4267 hsa-miR-548m hsa-miR-3613-3p hsa-miR-23a hsa-miR-296-5p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
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    Predesigned siRNA for gene silencing in human, mouse, rat VPS37D
    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: VPS37D (NM_001077621)
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat VPS37D
      QuantiFast Probe-based Assays in human, mouse, rat VPS37D

    Additional mRNA sequence: 

    AY081952.1 BC029730.1 BC064621.1 

    2 DOTS entries:

    DT.100018588  DT.95074989 

    Selected AceView cDNA sequences (see all 38):

    CR596679 BU740849 AW449892 CB216590 BX108782 BC064621 CR594226 BX410346 
    BC029730 BI823566 BM725417 AA913638 BE883379 AA862452 AL526252 BM701148 
    AI696387 BF593962 AI521163 AY081952 BQ954989 BM906293 AL526216 AA913175 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    VPS37D expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTCCAGACCC
    VPS37D Expression
    About this image

    VPS37D Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    VPS37D Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.647037
        Custom PCR Arrays for VPS37D
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VPS37D

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for VPS37D gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Vps37d1 , 5 vacuolar protein sorting 37D (yeast)1, 5 90.97(n)1
    96.02(a)1
      5 (74.98 cM)5
    1943091  NM_001199677.11  NP_001186606.11 
     1350729005 
    chicken
    (Gallus gallus)
    Aves VPS37D1 vacuolar protein sorting 37 homolog D (S. cerevisiae) 71.22(n)
    63.35(a)
      100859879  XM_003642373.1  XP_003642421.1 
    lizard
    (Anolis carolinensis)
    Reptilia VPS37D6
    vacuolar protein sorting 37 homolog D (S. cerevisi...
    46(a)
    1 ↔ 1
    GL344691.1(17272-20873)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia vps37d1 vacuolar protein sorting 37 homolog D (S. cerevisiae) 55.49(n)
    52.69(a)
      101733750  XM_004911761.1  XP_004911818.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1018848561 vacuolar protein sorting-associated protein 37D-like 49.73(n)
    40.32(a)
      101884856  XM_005172016.1  XP_005172073.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG11156
    --
    28(a)
    1 → many
    3R(1051882-1053248)
    worm
    (Caenorhabditis elegans)
    Secernentea vps-376
    Protein VPS-37 (vps-37) mRNA, complete cds
    22(a)
    1 → many
    V(5592707-5593608) WBGene00016990


    ENSEMBL Gene Tree for VPS37D (if available)
    TreeFam Gene Tree for VPS37D (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for VPS37D gene
    VPS37B2  VPS37C2  VPS37A2  
    2 SIMAP similar genes for VPS37D using alignment to 2 protein entries:     VP37D_HUMAN (see all proteins):
    VPS37C    VPS37B

    Find genes that share paralogs with VPS37D           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for VPS37D (see all 110)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1494580201,2
    --73080342(+) CGGCCA/GGCTAC 1 -- us2k10--------
    rs1828446441,2
    --73080535(+) TGACAC/TCTGCC 1 -- us2k10--------
    rs1439176541,2
    --73080606(+) CCTGAA/GGGCAG 1 -- us2k10--------
    rs18809521,2
    C,F,H--73080635(+) GCCTAG/ACCCAG 1 -- us2k116Minor allele frequency- A:0.03EA NS NA WA CSA 673
    rs1874805821,2
    --73080655(+) CAGAGC/TGGCAT 1 -- us2k10--------
    rs1916764091,2
    --73080737(+) GGAGGC/TGACAT 1 -- us2k10--------
    rs1996835461,2
    C--73080747(+) TCATC-/TCT   
      TTTTTT
    TCTTT
    1 -- us2k10--------
    rs345647621,2
    C,F--73080883(+) CCACCT/CGAGTA 1 -- us2k13Minor allele frequency- C:0.33NA CSA 6
    rs556683101,2
    C,F--73081019(+) CTACCG/ATGCCC 1 -- us2k11Minor allele frequency- A:0.50WA 2
    rs731388221,2
    C,F--73081117(+) CTATCC/TCTCAG 1 -- us2k12Minor allele frequency- T:0.21NA EA 240

    HapMap Linkage Disequilibrium report for VPS37D (73082155 - 73086442 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for VPS37D:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv831028CNV Loss17160897
    nsv888371CNV Loss21882294
    nsv888370CNV Loss21882294
    dgv7325n71CNV Loss21882294
    nsv469841CNV Complex16826518

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing VPS37D
    DNA2.0 Custom Variant and Variant Library Synthesis for VPS37D

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610039    OMIM disorders: --

    UniProtKB/Swiss-Prot: VP37D_HUMAN, Q86XT2
  • Note=VPS37D is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a
    hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing
    over between highly homologous low-copy repeat sequences flanking the deleted region

  • 2 diseases for VPS37D:    
    About MalaCards
    sall4-related disorders    williams-beuren syndrome

    1 disease from the University of Copenhagen DISEASES database for VPS37D:
    Williams-Beuren syndrome

    Find genes that share disorders with VPS37D           About GenesLikeMe


    Export disorders for VPS37D gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for VPS37D gene, integrated from 10 sources (see all 11):
    (articles sorted by number of sources associating them with VPS37D)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human endosomal sorting complex required for transport (ESCRT-I) and its role in HIV-1 budding. (PubMed id 15218037)1, 2, 3 Stuchell M.D.... Sundquist W.I. (J. Biol. Chem. 2004)
    2. Genomic study in Mexicans identifies a new locus for triglycerides and refines European lipid loci. (PubMed id 23505323)1 Weissglas-Volkov D....Pajukanta P. (J. Med. Genet. 2013)
    3. The UBAP1 subunit of ESCRT-I interacts with ubiquitin via a SOUBA domain. (PubMed id 22405001)2 Agromayor M.... Williams R.L. (Structure 2012)
    4. Large-scale proteomics and phosphoproteomics of urinary exosomes. (PubMed id 19056867)1 Gonzales P.A....Knepper M.A. (J. Am. Soc. Nephrol. 2009)
    5. Human ESCRT and ALIX proteins interact with proteins of the midbody and function in cytokinesis. (PubMed id 17853893)1 Morita E.... Sundquist W.I. (EMBO J. 2007)
    6. Identification of human MVB12 proteins as ESCRT-I subunits that function in HIV budding. (PubMed id 18005716)2 Morita E....Sundquist W.I. (Cell Host Microbe 2007)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. The DNA sequence of human chromosome 7. (PubMed id 12853948)2 Hillier L.W.... Wilson R.K. (Nature 2003)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    10. Secretory protein trafficking and organelle dynamics in living cells. (PubMed id 11031247)1 Lippincott-Schwartz J....Hirschberg K. (Annu. Rev. Cell Dev. Biol. 2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 155382 HGNC: 18287 AceView: WBSCR24 Ensembl:ENSG00000176428 euGenes: HUgn155382
    ECgene: VPS37D Kegg: 155382 H-InvDB: VPS37D

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for VPS37D Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for VPS37D gene:
    Search GeneIP for patents involving VPS37D

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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