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Aliases for VPS37C Gene

Aliases for VPS37C Gene

  • Vacuolar Protein Sorting 37 Homolog C (S. Cerevisiae) 2 3
  • ESCRT-I Complex Subunit VPS37C 3 4
  • HVps37C 3 4
  • Vacuolar Protein Sorting 37C (Yeast) 2
  • Vacuolar Protein Sorting 37C 3
  • PML39 4

External Ids for VPS37C Gene

Previous GeneCards Identifiers for VPS37C Gene

  • GC11M060655
  • GC11M060897
  • GC11M057243

Summaries for VPS37C Gene

Entrez Gene Summary for VPS37C Gene

  • VPS37C is a subunit of ESCRT-I (endosomal sorting complex required for transport I), a complex in the class E vacuolar protein sorting (VPS) pathway required for sorting ubiquitinated transmembrane proteins into internal vesicles of multivesicular bodies (Eastman et al., 2005 [PubMed 15509564]).[supplied by OMIM, Mar 2008]

GeneCards Summary for VPS37C Gene

VPS37C (Vacuolar Protein Sorting 37 Homolog C (S. Cerevisiae)) is a Protein Coding gene. Among its related pathways are Infectious disease and Endocytosis. GO annotations related to this gene include calcium-dependent protein binding. An important paralog of this gene is VPS37B.

UniProtKB/Swiss-Prot for VPS37C Gene

  • Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VPS37C Gene

Genomics for VPS37C Gene

Regulatory Elements for VPS37C Gene

Genomic Location for VPS37C Gene

Chromosome:
11
Start:
61,130,256 bp from pter
End:
61,161,617 bp from pter
Size:
31,362 bases
Orientation:
Minus strand

Genomic View for VPS37C Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for VPS37C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VPS37C Gene

Proteins for VPS37C Gene

  • Protein details for VPS37C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A5D8V6-VP37C_HUMAN
    Recommended name:
    Vacuolar protein sorting-associated protein 37C
    Protein Accession:
    A5D8V6
    Secondary Accessions:
    • Q8N3K4

    Protein attributes for VPS37C Gene

    Size:
    355 amino acids
    Molecular mass:
    38659 Da
    Quaternary structure:
    • Component of the ESCRT-I complex (endosomal sorting complex required for transport I) which consists of TSG101, VPS28, a VPS37 protein (VPS37A to -D) and MVB12A or MVB12B in a 1:1:1:1 stoechiometry. Interacts with TSG101, VPS28, MVB12A and MVB12B. Component of the ESCRT-I complex (endosomal sorting complex required for transport I) which consists of TSG101, VPS28, a VPS37 protein (VPS37A to -D) and UBAP1 in a 1:1:1:1 stoechiometry. Interacts with HGS and STAM2. Interacts with CEP55.
    SequenceCaution:
    • Sequence=CAD38936.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for VPS37C Gene

Proteomics data for VPS37C Gene at MOPED

Post-translational modifications for VPS37C Gene

Other Protein References for VPS37C Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for VPS37C Gene

Domains & Families for VPS37C Gene

Gene Families for VPS37C Gene

HGNC:

Protein Domains for VPS37C Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for VPS37C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A5D8V6

UniProtKB/Swiss-Prot:

VP37C_HUMAN :
  • Contains 1 VPS37 C-terminal domain.
  • Belongs to the VPS37 family.
Domain:
  • Contains 1 VPS37 C-terminal domain.
Family:
  • Belongs to the VPS37 family.
genes like me logo Genes that share domains with VPS37C: view

Function for VPS37C Gene

Molecular function for VPS37C Gene

UniProtKB/Swiss-Prot Function:
Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.

Gene Ontology (GO) - Molecular Function for VPS37C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 23924735
GO:0048306 calcium-dependent protein binding IPI 23924735
genes like me logo Genes that share ontologies with VPS37C: view

Phenotypes for VPS37C Gene

genes like me logo Genes that share phenotypes with VPS37C: view

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for VPS37C

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for VPS37C Gene

Localization for VPS37C Gene

Subcellular locations from UniProtKB/Swiss-Prot for VPS37C Gene

Late endosome membrane; Peripheral membrane protein. Note=Probably associates with membranes. Recruited to the plasma membrane by HIV-1.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for VPS37C Gene COMPARTMENTS Subcellular localization image for VPS37C gene
Compartment Confidence
endosome 5
extracellular 5
nucleus 2

Gene Ontology (GO) - Cellular Components for VPS37C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000813 ESCRT I complex IDA 18005716
GO:0010008 endosome membrane TAS --
GO:0031902 late endosome membrane IEA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with VPS37C: view

Pathways & Interactions for VPS37C Gene

genes like me logo Genes that share pathways with VPS37C: view

Pathways by source for VPS37C Gene

1 KEGG pathway for VPS37C Gene

Gene Ontology (GO) - Biological Process for VPS37C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015031 protein transport IEA --
GO:0016032 viral process TAS --
GO:0016197 endosomal transport TAS --
GO:0019058 viral life cycle TAS --
GO:0019068 virion assembly TAS --
genes like me logo Genes that share ontologies with VPS37C: view

No data available for SIGNOR curated interactions for VPS37C Gene

Drugs & Compounds for VPS37C Gene

No Compound Related Data Available

Transcripts for VPS37C Gene

Unigene Clusters for VPS37C Gene

Vacuolar protein sorting 37 homolog C (S. cerevisiae):
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for VPS37C

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for VPS37C Gene

No ASD Table

Relevant External Links for VPS37C Gene

GeneLoc Exon Structure for
VPS37C
ECgene alternative splicing isoforms for
VPS37C

Expression for VPS37C Gene

mRNA expression in normal human tissues for VPS37C Gene

Protein differential expression in normal tissues from HIPED for VPS37C Gene

This gene is overexpressed in Adrenal (38.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for VPS37C Gene



SOURCE GeneReport for Unigene cluster for VPS37C Gene Hs.523715

genes like me logo Genes that share expression patterns with VPS37C: view

Protein tissue co-expression partners for VPS37C Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for VPS37C Gene

Orthologs for VPS37C Gene

This gene was present in the common ancestor of animals.

Orthologs for VPS37C Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia VPS37C 35
  • 84.7 (n)
  • 84.49 (a)
VPS37C 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia VPS37C 35
  • 84.98 (n)
  • 85.07 (a)
VPS37C 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Vps37c 35
  • 80.98 (n)
  • 82.21 (a)
Vps37c 16
Vps37c 36
  • 82 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia VPS37C 35
  • 99.25 (n)
  • 98.31 (a)
VPS37C 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Vps37c 35
  • 81.14 (n)
  • 81.35 (a)
oppossum
(Monodelphis domestica)
Mammalia VPS37C 36
  • 62 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia VPS37C 36
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves VPS37C 36
  • 60 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia VPS37C 36
  • 59 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii VPS37C 36
  • 33 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG1115 36
  • 33 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea vps-37 36
  • 26 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10674 36
  • 28 (a)
OneToMany
Species with no ortholog for VPS37C:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for VPS37C Gene

ENSEMBL:
Gene Tree for VPS37C (if available)
TreeFam:
Gene Tree for VPS37C (if available)

Paralogs for VPS37C Gene

Paralogs for VPS37C Gene

(3) SIMAP similar genes for VPS37C Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with VPS37C: view

Variants for VPS37C Gene

Sequence variations from dbSNP and Humsavar for VPS37C Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs7876 -- 61,130,440(-) GCCTA(C/T)GTGCC utr-variant-3-prime
rs98696 -- 61,153,622(-) gtcca(A/G)tgttt intron-variant
rs471718 -- 61,146,015(-) TCTCC(G/T)TGTCT intron-variant
rs478336 -- 61,145,228(-) GCAGT(A/G)TCCTT intron-variant
rs479966 -- 61,145,109(-) GGCTT(A/T)GATCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for VPS37C Gene

Variant ID Type Subtype PubMed ID
nsv832176 CNV Gain+Loss 17160897
nsv428259 CNV Gain+Loss 18775914
nsv509412 CNV Insertion 20534489
nsv897602 CNV Loss 21882294
dgv390e1 CNV Complex 17122850
nsv8832 CNV Gain 18304495

Variation tolerance for VPS37C Gene

Residual Variation Intolerance Score: 89.85% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.33; 53.53% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for VPS37C Gene

HapMap Linkage Disequilibrium report
VPS37C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VPS37C Gene

Disorders for VPS37C Gene

Relevant External Links for VPS37C

Genetic Association Database (GAD)
VPS37C
Human Genome Epidemiology (HuGE) Navigator
VPS37C
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
VPS37C
genes like me logo Genes that share disorders with VPS37C: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for VPS37C Gene

Publications for VPS37C Gene

  1. Identification of human VPS37C, a component of endosomal sorting complex required for transport-I important for viral budding. (PMID: 15509564) Eastman S.W. … Bieniasz P.D. (J. Biol. Chem. 2005) 2 23 67
  2. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 67
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 67
  4. The molecular basis for selective assembly of the UBAP1-containing endosome-specific ESCRT-I complex. (PMID: 24284069) Wunderley L. … Woodman P. (J. Cell. Sci. 2014) 67
  5. Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes? (PMID: 23314748) Nathan J.A. … Goldberg A.L. (EMBO J. 2013) 67

Products for VPS37C Gene

Sources for VPS37C Gene

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