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Aliases for VPS37C Gene

Aliases for VPS37C Gene

  • VPS37C, ESCRT-I Subunit 2 3 5
  • ESCRT-I Complex Subunit VPS37C 3 4
  • HVps37C 3 4
  • Vacuolar Protein Sorting 37 Homolog C (S. Cerevisiae) 2
  • Vacuolar Protein Sorting-Associated Protein 37C 3
  • Vacuolar Protein Sorting 37 Homolog C 3
  • Vacuolar Protein Sorting 37C (Yeast) 2
  • Vacuolar Protein Sorting 37C 3
  • PML39 4

External Ids for VPS37C Gene

Previous GeneCards Identifiers for VPS37C Gene

  • GC11M060655
  • GC11M060897
  • GC11M057243

Summaries for VPS37C Gene

Entrez Gene Summary for VPS37C Gene

  • VPS37C is a subunit of ESCRT-I (endosomal sorting complex required for transport I), a complex in the class E vacuolar protein sorting (VPS) pathway required for sorting ubiquitinated transmembrane proteins into internal vesicles of multivesicular bodies (Eastman et al., 2005 [PubMed 15509564]).[supplied by OMIM, Mar 2008]

GeneCards Summary for VPS37C Gene

VPS37C (VPS37C, ESCRT-I Subunit) is a Protein Coding gene. Among its related pathways are HIV Life Cycle and Budding and maturation of HIV virion. GO annotations related to this gene include calcium-dependent protein binding. An important paralog of this gene is VPS37B.

UniProtKB/Swiss-Prot for VPS37C Gene

  • Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.

Additional gene information for VPS37C Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VPS37C Gene

Genomics for VPS37C Gene

Regulatory Elements for VPS37C Gene

Enhancers for VPS37C Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11H062041 1.4 ENCODE dbSUPER 31.7 -883.8 -883811 8 PKNOX1 ARNT ZFP64 FEZF1 ZNF766 FOS SP3 ZC3H11A REST SREBF1 METTL12 CPSF7 SNHG1 GANAB LOC105369332 NXF1 TMEM138 TUT1 INTS5 MTA2
GH11H061960 1.8 FANTOM5 ENCODE dbSUPER 21.9 -807.3 -807307 16 MLX ZFP64 DMAP1 YBX1 YY1 SLC30A9 ZNF143 SP3 NFYC MEF2D UBXN1 LOC105369332 WDR74 INTS5 MTA2 CPSF7 TMEM138 NXF1 EML3 STX5
GH11H061428 1.3 ENCODE dbSUPER 20.6 -268.3 -268314 3 PKNOX1 MLX ARID4B SIN3A YBX1 DMAP1 ZNF2 ZBTB7B YY1 ZNF207 CPSF7 TMEM216 VPS37C TMEM138 RN7SL23P TMEM109 DDB1 TKFC SDHAF2 ENSG00000256591
GH11H062032 1.7 FANTOM5 Ensembl ENCODE dbSUPER 11.3 -872.3 -872258 1 BCOR HDAC1 LEF1 SAP130 ARNT ZMYM3 MAX RARA CTBP1 POLR2A WDR74 METTL12 INTS5 VPS37C CPSF7 LRRN4CL UBXN1 TUT1 TAF6L RAB3IL1
GH11H061916 1.6 Ensembl ENCODE dbSUPER 11.3 -756.9 -756941 4 HDGF PKNOX1 ATF1 SIN3A ZBTB7B TCF12 ELK1 GATA2 ATF7 SP3 RAB3IL1 METTL12 CPSF7 TUT1 TAF6L WDR74 GANAB SNHG1 FADS3 BEST1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around VPS37C on UCSC Golden Path with GeneCards custom track

Promoters for VPS37C Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000040209 217 1601 HDGF FOXA2 MLX SIN3A DMAP1 ZNF2 ZBTB7B ZNF143 ZNF207 SP3

Genomic Location for VPS37C Gene

Chromosome:
11
Start:
61,130,256 bp from pter
End:
61,161,617 bp from pter
Size:
31,362 bases
Orientation:
Minus strand

Genomic View for VPS37C Gene

Genes around VPS37C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
VPS37C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for VPS37C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VPS37C Gene

Proteins for VPS37C Gene

  • Protein details for VPS37C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A5D8V6-VP37C_HUMAN
    Recommended name:
    Vacuolar protein sorting-associated protein 37C
    Protein Accession:
    A5D8V6
    Secondary Accessions:
    • Q8N3K4

    Protein attributes for VPS37C Gene

    Size:
    355 amino acids
    Molecular mass:
    38659 Da
    Quaternary structure:
    • Component of the ESCRT-I complex (endosomal sorting complex required for transport I) which consists of TSG101, VPS28, a VPS37 protein (VPS37A to -D) and MVB12A or MVB12B in a 1:1:1:1 stoichiometry. Interacts with TSG101, VPS28, MVB12A and MVB12B. Component of the ESCRT-I complex (endosomal sorting complex required for transport I) which consists of TSG101, VPS28, a VPS37 protein (VPS37A to -D) and UBAP1 in a 1:1:1:1 stoichiometry. Interacts with HGS and STAM2. Interacts with CEP55.
    SequenceCaution:
    • Sequence=CAD38936.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for VPS37C Gene

Post-translational modifications for VPS37C Gene

Other Protein References for VPS37C Gene

No data available for DME Specific Peptides for VPS37C Gene

Domains & Families for VPS37C Gene

Gene Families for VPS37C Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for VPS37C Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for VPS37C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A5D8V6

UniProtKB/Swiss-Prot:

VP37C_HUMAN :
  • Belongs to the VPS37 family.
Family:
  • Belongs to the VPS37 family.
genes like me logo Genes that share domains with VPS37C: view

Function for VPS37C Gene

Molecular function for VPS37C Gene

UniProtKB/Swiss-Prot Function:
Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.

Phenotypes From GWAS Catalog for VPS37C Gene

Gene Ontology (GO) - Molecular Function for VPS37C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17853893
GO:0046983 protein dimerization activity IEA --
GO:0048306 calcium-dependent protein binding IPI 23924735
genes like me logo Genes that share ontologies with VPS37C: view
genes like me logo Genes that share phenotypes with VPS37C: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for VPS37C
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for VPS37C Gene

Localization for VPS37C Gene

Subcellular locations from UniProtKB/Swiss-Prot for VPS37C Gene

Late endosome membrane; Peripheral membrane protein. Note=Probably associates with membranes. Recruited to the plasma membrane by HIV-1.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for VPS37C gene
Compartment Confidence
extracellular 5
endosome 5
nucleus 4
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleus (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for VPS37C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000813 ESCRT I complex TAS 20588296
GO:0005768 endosome IEA --
GO:0010008 endosome membrane TAS --
GO:0016020 membrane IEA --
GO:0031902 late endosome membrane IEA --
genes like me logo Genes that share ontologies with VPS37C: view

Pathways & Interactions for VPS37C Gene

genes like me logo Genes that share pathways with VPS37C: view

Pathways by source for VPS37C Gene

Gene Ontology (GO) - Biological Process for VPS37C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0015031 protein transport IEA --
GO:0016197 endosomal transport TAS --
GO:0016236 macroautophagy TAS 20588296
GO:0019058 viral life cycle TAS --
genes like me logo Genes that share ontologies with VPS37C: view

No data available for SIGNOR curated interactions for VPS37C Gene

Drugs & Compounds for VPS37C Gene

No Compound Related Data Available

Transcripts for VPS37C Gene

Unigene Clusters for VPS37C Gene

Vacuolar protein sorting 37 homolog C (S. cerevisiae):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for VPS37C
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for VPS37C Gene

No ASD Table

Relevant External Links for VPS37C Gene

GeneLoc Exon Structure for
VPS37C
ECgene alternative splicing isoforms for
VPS37C

Expression for VPS37C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for VPS37C Gene

Protein differential expression in normal tissues from HIPED for VPS37C Gene

This gene is overexpressed in Adrenal (38.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for VPS37C Gene



Protein tissue co-expression partners for VPS37C Gene

NURSA nuclear receptor signaling pathways regulating expression of VPS37C Gene:

VPS37C

SOURCE GeneReport for Unigene cluster for VPS37C Gene:

Hs.523715

Evidence on tissue expression from TISSUES for VPS37C Gene

  • Nervous system(4.4)
genes like me logo Genes that share expression patterns with VPS37C: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for VPS37C Gene

Orthologs for VPS37C Gene

This gene was present in the common ancestor of animals.

Orthologs for VPS37C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia VPS37C 33 34
  • 99.25 (n)
dog
(Canis familiaris)
Mammalia VPS37C 33 34
  • 84.98 (n)
cow
(Bos Taurus)
Mammalia VPS37C 33 34
  • 84.7 (n)
rat
(Rattus norvegicus)
Mammalia LOC100910929 33
  • 81.14 (n)
mouse
(Mus musculus)
Mammalia Vps37c 33 16 34
  • 80.98 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia VPS37C 34
  • 65 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia VPS37C 34
  • 62 (a)
OneToOne
chicken
(Gallus gallus)
Aves VPS37C 34
  • 60 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia VPS37C 34
  • 59 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii VPS37C 34
  • 33 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG1115 34
  • 33 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea vps-37 34
  • 26 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10674 34
  • 28 (a)
OneToMany
Species where no ortholog for VPS37C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for VPS37C Gene

ENSEMBL:
Gene Tree for VPS37C (if available)
TreeFam:
Gene Tree for VPS37C (if available)

Paralogs for VPS37C Gene

Paralogs for VPS37C Gene

(3) SIMAP similar genes for VPS37C Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with VPS37C: view

Variants for VPS37C Gene

Sequence variations from dbSNP and Humsavar for VPS37C Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000005211 -- 61,153,116(+) TGGCT(C/T)GGTGC intron-variant
rs1000221270 -- 61,146,826(+) TTTAA(A/G)GTTGT intron-variant
rs1000243183 -- 61,137,305(+) TGAAG(C/T)CTAAG intron-variant
rs1000314390 -- 61,137,035(+) GTTGC(A/G)AAGTG intron-variant
rs1000503490 -- 61,130,175(+) AGAGA(A/G)CACGA downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for VPS37C Gene

Variant ID Type Subtype PubMed ID
esv2759831 CNV gain+loss 17122850
nsv428259 CNV gain+loss 18775914
nsv509412 CNV insertion 20534489
nsv832176 CNV gain+loss 17160897
nsv8832 CNV gain 18304495

Variation tolerance for VPS37C Gene

Residual Variation Intolerance Score: 89.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.33; 53.53% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for VPS37C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
VPS37C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VPS37C Gene

Disorders for VPS37C Gene

Relevant External Links for VPS37C

Genetic Association Database (GAD)
VPS37C
Human Genome Epidemiology (HuGE) Navigator
VPS37C
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
VPS37C

No disorders were found for VPS37C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for VPS37C Gene

Publications for VPS37C Gene

  1. Identification of human VPS37C, a component of endosomal sorting complex required for transport-I important for viral budding. (PMID: 15509564) Eastman SW … Bieniasz PD (The Journal of biological chemistry 2005) 2 3 4 22 60
  2. The UBAP1 subunit of ESCRT-I interacts with ubiquitin via a SOUBA domain. (PMID: 22405001) Agromayor M … Williams RL (Structure (London, England : 1993) 2012) 3 4 60
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  4. Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity. (PMID: 19773279) Hosgood HD … Lan Q (Occupational and environmental medicine 2009) 3 45 60
  5. Identification of human MVB12 proteins as ESCRT-I subunits that function in HIV budding. (PMID: 18005716) Morita E … Sundquist WI (Cell host & microbe 2007) 3 4 60

Products for VPS37C Gene

Sources for VPS37C Gene

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