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VPS37C Gene

protein-coding   GIFtS: 57
GCID: GC11M060897

Vacuolar Protein Sorting 37 Homolog C (S. Cerevisiae)

(Previous name: vacuolar protein sorting 37C (yeast))
  Search for VPS37C
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Vacuolar Protein Sorting 37 Homolog C (S. Cerevisiae)1 2     Vacuolar Protein Sorting 37C2
ESCRT-I Complex Subunit VPS37C2 3     Vacuolar Protein Sorting-Associated Protein 37C2
hVps37C2 3     PML393
Vacuolar Protein Sorting 37C (Yeast)1     

External Ids:    HGNC: 260971   Entrez Gene: 550482   Ensembl: ENSG000001679877   OMIM: 6100385   UniProtKB: A5D8V63   
ORGUL members:         

Export aliases for VPS37C gene to outside databases

Previous GC identifers: GC11M060655 GC11M057243


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for VPS37C Gene:
VPS37C is a subunit of ESCRT-I (endosomal sorting complex required for transport I), a complex in the class E
vacuolar protein sorting (VPS) pathway required for sorting ubiquitinated transmembrane proteins into internal
vesicles of multivesicular bodies (Eastman et al., 2005 (PubMed 15509564)).(supplied by OMIM, Mar 2008)

GeneCards Summary for VPS37C Gene:
VPS37C (vacuolar protein sorting 37 homolog C (S. cerevisiae)) is a protein-coding gene. An important paralog of this gene is VPS37B.

UniProtKB/Swiss-Prot: VP37C_HUMAN, A5D8V6
Function: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting
of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NT_167190.2  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the VPS37C gene promoter:
         Spz1   Pbx1a   AP-1   MEF-2   Chx10   Lmo2   aMEF-2   Tal-1beta   MRF-2   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidVPS37C promoter sequence
   Search Chromatin IP Primers for VPS37C

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat VPS37C


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q12.2   Ensembl cytogenetic band:  11q12.2   HGNC cytogenetic band: 11q12.2

VPS37C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
VPS37C gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M060897:  view genomic region     (about GC identifiers)

Start:
60,897,728 bp from pter      End:
60,929,089 bp from pter
Size:
31,362 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: VP37C_HUMAN, A5D8V6 (See protein sequence)
Recommended Name: Vacuolar protein sorting-associated protein 37C  
Size: 355 amino acids; 38659 Da
Subunit: Component of the ESCRT-I complex (endosomal sorting complex required for transport I) which consists of
TSG101, VPS28, a VPS37 protein (VPS37A to -D) and MVB12A or MVB12B in a 1:1:1:1 stoechiometry. Interacts with
TSG101, VPS28, MVB12A and MVB12B. Component of the ESCRT-I complex (endosomal sorting complex required for
transport I) which consists of TSG101, VPS28, a VPS37 protein (VPS37A to -D) and UBAP1 in a 1:1:1:1
stoechiometry. Interacts with HGS and STAM2. Interacts with CEP55
Sequence caution: Sequence=CAD38936.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: Q8N3K4

Explore the universe of human proteins at neXtProt for VPS37C: NX_A5D8V6

Explore proteomics data for VPS37C at MOPED

Post-translational modifications: 

  • Phosphorylated by TBK11
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See VPS37C Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_060436.4  
    ENSEMBL proteins: 
     ENSP00000301765   ENSP00000446013  
    Reactome Protein details: A5D8V6

    VPS37C Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR009851 Mod_r

    Graphical View of Domain Structure for InterPro Entry A5D8V6

    ProtoNet protein and cluster: A5D8V6

    UniProtKB/Swiss-Prot: VP37C_HUMAN, A5D8V6
    Similarity: Belongs to the VPS37 family
    Similarity: Contains 1 VPS37 C-terminal domain


    Find genes that share domains with VPS37C           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: VP37C_HUMAN, A5D8V6
    Function: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting
    of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation

    Phenotypes:
         1 GenomeRNAi human phenotype for VPS37C:

     Decreased homologous recombina 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for VPS37C
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for VPS37C
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for VPS37C

    miRNA
    Products:
        
    miRTarBase miRNAs that target VPS37C:
    hsa-mir-744-5p (MIRT037445), hsa-mir-124-3p (MIRT004898)

    Block miRNA regulation of human, mouse, rat VPS37C using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate VPS37C (see all 28):
    hsa-miR-631 hsa-miR-15a hsa-miR-2909 hsa-miR-503 hsa-miR-29a hsa-miR-29c hsa-miR-885-5p hsa-miR-486-3p
    SwitchGear 3'UTR luciferase reporter plasmidVPS37C 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat VPS37C

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    VP37C_HUMAN, A5D8V6: Late endosome membrane; Peripheral membrane protein (Probable). Note=Probably associates
    with membranes. Recruited to the plasma membrane by HIV-1
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endosome5
    nucleus4
    cytosol2

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000813ESCRT I complex IDA--
    GO:0005634nucleus ----
    GO:0010008endosome membrane TAS--
    GO:0031902late endosome membrane IEA--
    GO:0043231intracellular membrane-bounded organelle ----

    Find genes that share ontologies with VPS37C           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for VPS37C About    
    See pathways by source

    SuperPathContained pathways About
    1HIV Life Cycle
    HIV Life Cycle0.91
    Membrane binding and targetting of GAG proteins0.00
    Late Phase of HIV Life Cycle0.91
    Assembly Of The HIV Virion0.00
    HIV Infection0.62
    2Budding and maturation of HIV virion
    Budding and maturation of HIV virion0.64
    Endosomal Sorting Complex Required For Transport (ESCRT)0.64
    3Clathrin derived vesicle budding
    Membrane Trafficking0.32
    4Endocytosis
    Endocytosis
    5Disease
    Disease


    Find genes that share SuperPaths with VPS37C           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 Reactome Pathways for VPS37C
        Budding and maturation of HIV virion
    Membrane binding and targetting of GAG proteins
    Endosomal Sorting Complex Required For Transport (ESCRT)


    1 Kegg Pathway  (Kegg details for VPS37C):
        Endocytosis

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for VPS37C
    Interactions:

        Search GeneGlobe Interaction Network for VPS37C

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for VPS37C (A5D8V62, 3 ENSP000003017654) via UniProtKB, MINT, STRING, and/or I2D (see all 30)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CEP55Q53EZ42, 3, ENSP000003605404MINT-6173464 MINT-6173613 I2D: score=2 STRING: ENSP00000360540
    PARP2Q9UGN52, 3, ENSP000002504164MINT-8201989 I2D: score=1 STRING: ENSP00000250416
    PDCD6IPQ8WUM42, 3, ENSP000003073874MINT-6173613 I2D: score=1 STRING: ENSP00000307387
    TSG101Q998163, ENSP000002519684I2D: score=2 STRING: ENSP00000251968
    ABI2Q9NYB93, ENSP000002610174I2D: score=1 STRING: ENSP00000261017
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0015031protein transport IEA--
    GO:0016032viral process TAS--
    GO:0016197endosomal transport TAS--
    GO:0019058viral life cycle TAS--
    GO:0019068virion assembly TAS--

    Find genes that share ontologies with VPS37C           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for VPS37C (VP37C)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for VPS37C gene: 
    NM_017966.4  

    Unigene Cluster for VPS37C:

    Vacuolar protein sorting 37 homolog C (S. cerevisiae)
    Hs.523715  [show with all ESTs]
    Unigene Representative Sequence: AL834261
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000301765(uc001nqv.1) ENST00000538036 ENST00000536000(uc001nqw.1)
    ENST00000535818
    miRNA
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    Block miRNA regulation of human, mouse, rat VPS37C using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate VPS37C (see all 28):
    hsa-miR-631 hsa-miR-15a hsa-miR-2909 hsa-miR-503 hsa-miR-29a hsa-miR-29c hsa-miR-885-5p hsa-miR-486-3p
    SwitchGear 3'UTR luciferase reporter plasmidVPS37C 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: VPS37C (NM_017966)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VPS37C
    Primer
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    OriGene qPCR primer pairs and template standards for VPS37C
    OriGene qSTAR qPCR primer pairs in human, mouse for VPS37C
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat VPS37C
      QuantiTect SYBR Green Assays in human, mouse, rat VPS37C
      QuantiFast Probe-based Assays in human, mouse, rat VPS37C

    Additional mRNA sequence: 

    AK000854.1 AK097326.1 AK302384.1 AL834261.1 BC005805.2 BC062604.1 BC141827.1 BC142702.1 
    CR457250.1 

    9 DOTS entries:

    DT.99977975  DT.413054  DT.120716071  DT.86859494  DT.91830877  DT.95234719  DT.120716242  DT.102830960 
    DT.120716148 

    Selected AceView cDNA sequences (see all 130):

    BQ070499 AI669525 BU151366 BM987525 BQ943441 BQ072093 BF513919 BU501884 
    BM053070 BU739661 CD672156 CR621619 BQ961670 AA354592 BE857256 AA357663 
    BM909289 AI804355 BM720494 CK903982 BM476867 AI868988 BU069043 BM719789 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    VPS37C expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTCAGTAATA
    VPS37C Expression
    About this image

    VPS37C Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    VPS37C Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.523715
        Custom PCR Arrays for VPS37C
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VPS37C

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for VPS37C gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Vps37c1 , 5 vacuolar protein sorting 37C (yeast)1, 5 80.98(n)1
    82.21(a)1
      19 (7.16 cM)5
    1073051  NM_181403.21  NP_852068.11 
     106888155 
    chicken
    (Gallus gallus)
    Aves VPS37C6
    vacuolar protein sorting 37 homolog C (S. cerevisi...
    60(a)
    1 ↔ 1
    5(441436-444192) ENSGALG00000005197
    lizard
    (Anolis carolinensis)
    Reptilia VPS37C6
    vacuolar protein sorting 37 homolog C (S. cerevisi...
    59(a)
    1 ↔ 1
    GL343235.1(670992-675618)
    zebrafish
    (Danio rerio)
    Actinopterygii VPS37C6
    vacuolar protein sorting 37 homolog C (S. cerevisi...
    33(a)
    1 ↔ 1
    1(45405387-45418016) ENSDARG00000031836
    fruit fly
    (Drosophila melanogaster)
    Insecta CG11156
    --
    33(a)
    1 → many
    3R(1051882-1053248)
    worm
    (Caenorhabditis elegans)
    Secernentea vps-376
    Protein VPS-37 (vps-37) mRNA, complete cds
    26(a)
    1 → many
    V(5592707-5593608) WBGene00016990


    ENSEMBL Gene Tree for VPS37C (if available)
    TreeFam Gene Tree for VPS37C (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for VPS37C gene
    VPS37B2  VPS37D2  VPS37A2  
    3 SIMAP similar genes for VPS37C using alignment to 2 protein entries:     VP37C_HUMAN (see all proteins):
    VPS37B    VPS37A    VPS37D

    Find genes that share paralogs with VPS37C           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for VPS37C (see all 739)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs122883121,2
    C,F,H--60897289(+) TTTAGC/TGGCCT 1 -- ds500113Minor allele frequency- T:0.13NS EA NA WA CSA 1206
    rs1467456061,2
    --60897314(+) CCCATC/GCTGCA 1 -- ds50010--------
    rs1824531281,2
    --60897332(+) GTTAGA/GATTAG 1 -- ds50010--------
    rs122701471,2
    C,F--60897334(+) TAGAAT/ATAGAT 1 -- ds50013Minor allele frequency- A:0.25WA 122
    rs108971411,2
    C,F,A,H--60897339(+) TTAGAC/TGGCTC 1 -- ds500125Minor allele frequency- T:0.31NA NS EA WA CSA 2399
    rs1875480001,2
    --60897435(+) CCCCTC/GGTGGC 1 -- ds50010--------
    rs749788881,2
    C,F--60897496(+) AGGCTC/TCAATA 1 -- ds50011Minor allele frequency- T:0.02NA 120
    rs1915402551,2
    --60897508(+) GAAAAC/TGGCTA 1 -- ds50010--------
    rs1828518471,2
    C--60897553(+) AATACA/TCCCAG 1 -- ds50010--------
    rs1404281331,2
    --60897666(+) CTGCAG/TAAGAG 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for VPS37C (60897728 - 60929089 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for VPS37C:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv509412CNV Insertion20534489
    nsv897602CNV Loss21882294
    nsv8832CNV Gain18304495
    nsv428259CNV Gain+Loss18775914
    nsv832176CNV Gain+Loss17160897
    dgv390e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing VPS37C
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610038    OMIM disorders: --


    Find genes that share disorders with VPS37C           About GenesLikeMe

    Genetic Association Database (GAD): VPS37C
    Human Genome Epidemiology (HuGE) Navigator: VPS37C (2 documents)

    Export disorders for VPS37C gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for VPS37C gene, integrated from 10 sources (see all 22):
    (articles sorted by number of sources associating them with VPS37C)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of human VPS37C, a component of endosomal sorting complex required for transport-I important for viral budding. (PubMed id 15509564)1, 2, 3, 9 Eastman S.W.... Bieniasz P.D. (J. Biol. Chem. 2005)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity. (PubMed id 19773279)1, 4 Hosgood H.D....Lan Q. (Occup Environ Med 2009)
    4. Human ESCRT and ALIX proteins interact with proteins of the midbody and function in cytokinesis. (PubMed id 17853893)1, 2 Morita E.... Sundquist W.I. (EMBO J. 2007)
    5. Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes? (PubMed id 23314748)1 Nathan J.A....Goldberg A.L. (EMBO J. 2013)
    6. The UBAP1 subunit of ESCRT-I interacts with ubiquitin via a SOUBA domain. (PubMed id 22405001)2 Agromayor M.... Williams R.L. (Structure 2012)
    7. TANK-binding kinase 1 attenuates PTAP-dependent retroviral budding through targeting endosomal sorting complex required for transport- I. (PubMed id 21270402)2 Da Q.... Tang H. (J. Immunol. 2011)
    8. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    9. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
    10. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
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      Query String
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    OMIM
    NCBI Bookshelf
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55048 HGNC: 26097 AceView: FLJ20847 Ensembl:ENSG00000167987 euGenes: HUgn55048
    ECgene: VPS37C Kegg: 55048 H-InvDB: VPS37C

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for VPS37C Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for VPS37C gene:
    Search GeneIP for patents involving VPS37C

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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