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Aliases for VPS37B Gene

Aliases for VPS37B Gene

  • VPS37B, ESCRT-I Subunit 2 3 5
  • ESCRT-I Complex Subunit VPS37B 3 4
  • HVps37B 3 4
  • Vacuolar Protein Sorting 37 Homolog B (S. Cerevisiae) 2
  • Vacuolar Protein Sorting-Associated Protein 37B 3
  • Vacuolar Protein Sorting 37 Homolog B 3
  • Vacuolar Protein Sorting 37B (Yeast) 2
  • Vacuolar Protein Sorting 37B 3

External Ids for VPS37B Gene

Previous GeneCards Identifiers for VPS37B Gene

  • GC12M121875
  • GC12M123349
  • GC12M120309

Summaries for VPS37B Gene

GeneCards Summary for VPS37B Gene

VPS37B (VPS37B, ESCRT-I Subunit) is a Protein Coding gene. Among its related pathways are Vesicle-mediated transport and Budding and maturation of HIV virion. Gene Ontology (GO) annotations related to this gene include calcium-dependent protein binding. An important paralog of this gene is VPS37C.

UniProtKB/Swiss-Prot for VPS37B Gene

  • Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.

Additional gene information for VPS37B Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VPS37B Gene

Genomics for VPS37B Gene

GeneHancer (GH) Regulatory Elements for VPS37B Gene

Promoters and enhancers for VPS37B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12I122885 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 569.8 +4.8 4836 11.5 CLOCK IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 GLIS1 RCOR2 NBN VPS37B KNTC1 ZCCHC8 RSRC2 DDX55 EIF2B1 ATP6V0A2 OGFOD2 LOC101927415 PITPNM2
GH12I122834 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 18.1 +57.7 57698 9.3 PKNOX1 FOXA2 ARID4B SIN3A YBX1 FEZF1 ZNF2 YY1 ZNF213 FOS HIP1R VPS37B ATP6V0A2 TCTN2 ABCB9 B3GNT4 PIR62748
GH12I122866 Enhancer 1.2 FANTOM5 ENCODE dbSUPER 31.9 +28.7 28675 2.7 FOXA2 RB1 ARID4B SIN3A DMAP1 RAD21 RARA YY1 SCRT2 ZNF143 GC12M122867 PIR39782 PIR41686 VPS37B HIP1R CCDC62 PITPNM2 B3GNT4 ENSG00000256152
GH12I122870 Promoter/Enhancer 1.5 Ensembl ENCODE dbSUPER 24.4 +24.2 24196 4.3 HDGF MZF1 SIN3A BATF IRF4 ETS1 SCRT2 ATF7 ETV6 IKZF2 VPS37B HIP1R CCDC62 B3GNT4 PIR39782 ENSG00000280138
GH12I122879 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 23.3 +13.9 13886 6.1 ZSCAN4 INSM2 FEZF1 ZNF2 RAD21 ZNF366 ZNF391 RUNX3 ZNF362 ZNF654 VPS37B OGFOD2 ABCB9 B3GNT4 ENSG00000280138 PIR39782
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around VPS37B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the VPS37B gene promoter:

Genomic Locations for VPS37B Gene

Genomic Locations for VPS37B Gene
chr12:122,865,328-122,896,444
(GRCh38/hg38)
Size:
31,117 bases
Orientation:
Minus strand
chr12:123,349,875-123,380,991
(GRCh37/hg19)

Genomic View for VPS37B Gene

Genes around VPS37B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
VPS37B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for VPS37B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VPS37B Gene

Proteins for VPS37B Gene

  • Protein details for VPS37B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H9H4-VP37B_HUMAN
    Recommended name:
    Vacuolar protein sorting-associated protein 37B
    Protein Accession:
    Q9H9H4

    Protein attributes for VPS37B Gene

    Size:
    285 amino acids
    Molecular mass:
    31307 Da
    Quaternary structure:
    • Component of the ESCRT-I complex (endosomal sorting complex required for transport I) which consists of TSG101, VPS28, a VPS37 protein (VPS37A to -D) and MVB12A or MVB12B in a 1:1:1:1 stoichiometry. Interacts with TSG101, VPS28, MVB12A and MVB12B. Component of the ESCRT-I complex (endosomal sorting complex required for transport I) which consists of TSG101, VPS28, a VPS37 protein (VPS37A to -D) and UBAP1 in a 1:1:1:1 stoichiometry. Interacts with CEP55. Interacts with IST1.

neXtProt entry for VPS37B Gene

Post-translational modifications for VPS37B Gene

No Post-translational modifications

No data available for DME Specific Peptides for VPS37B Gene

Domains & Families for VPS37B Gene

Gene Families for VPS37B Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for VPS37B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for VPS37B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H9H4

UniProtKB/Swiss-Prot:

VP37B_HUMAN :
  • Belongs to the VPS37 family.
Family:
  • Belongs to the VPS37 family.
genes like me logo Genes that share domains with VPS37B: view

Function for VPS37B Gene

Molecular function for VPS37B Gene

UniProtKB/Swiss-Prot Function:
Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.

Phenotypes From GWAS Catalog for VPS37B Gene

Gene Ontology (GO) - Molecular Function for VPS37B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15218037
GO:0048306 calcium-dependent protein binding IPI 23924735
genes like me logo Genes that share ontologies with VPS37B: view
genes like me logo Genes that share phenotypes with VPS37B: view

miRNA for VPS37B Gene

miRTarBase miRNAs that target VPS37B

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for VPS37B Gene

Localization for VPS37B Gene

Subcellular locations from UniProtKB/Swiss-Prot for VPS37B Gene

Late endosome membrane; Peripheral membrane protein. Note=Recruited to the endosomal membrane in a VPS4A-dependent fashion.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for VPS37B gene
Compartment Confidence
plasma membrane 5
extracellular 5
endosome 5
nucleus 2
cytosol 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for VPS37B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000813 ESCRT I complex TAS 20588296
GO:0005737 cytoplasm IDA 15218037
GO:0005768 endosome IDA,IEA 17940959
GO:0005886 plasma membrane IDA 17940959
GO:0010008 endosome membrane TAS,IDA --
genes like me logo Genes that share ontologies with VPS37B: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for VPS37B Gene

Pathways & Interactions for VPS37B Gene

genes like me logo Genes that share pathways with VPS37B: view

Pathways by source for VPS37B Gene

Gene Ontology (GO) - Biological Process for VPS37B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0015031 protein transport IEA --
GO:0016197 endosomal transport TAS --
GO:0016236 macroautophagy TAS 20588296
GO:0019058 viral life cycle TAS --
genes like me logo Genes that share ontologies with VPS37B: view

No data available for SIGNOR curated interactions for VPS37B Gene

Drugs & Compounds for VPS37B Gene

No Compound Related Data Available

Transcripts for VPS37B Gene

Unigene Clusters for VPS37B Gene

Vacuolar protein sorting 37 homolog B (S. cerevisiae):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for VPS37B Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b
SP1: - -
SP2: -
SP3:

Relevant External Links for VPS37B Gene

GeneLoc Exon Structure for
VPS37B
ECgene alternative splicing isoforms for
VPS37B

Expression for VPS37B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for VPS37B Gene

mRNA differential expression in normal tissues according to GTEx for VPS37B Gene

This gene is overexpressed in Whole Blood (x4.5).

Protein differential expression in normal tissues from HIPED for VPS37B Gene

This gene is overexpressed in Breast (17.9), Urine (9.0), and Peripheral blood mononuclear cells (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for VPS37B Gene



Protein tissue co-expression partners for VPS37B Gene

NURSA nuclear receptor signaling pathways regulating expression of VPS37B Gene:

VPS37B

SOURCE GeneReport for Unigene cluster for VPS37B Gene:

Hs.507162

mRNA Expression by UniProt/SwissProt for VPS37B Gene:

Q9H9H4-VP37B_HUMAN
Tissue specificity: Widely expressed. Expressed in macrophages and lymphocytes.

Evidence on tissue expression from TISSUES for VPS37B Gene

  • Muscle(4.2)
  • Nervous system(3.5)
  • Gall bladder(2)
  • Intestine(2)
  • Lymph node(2)
  • Stomach(2)
genes like me logo Genes that share expression patterns with VPS37B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for VPS37B Gene

Orthologs for VPS37B Gene

This gene was present in the common ancestor of animals.

Orthologs for VPS37B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia VPS37B 33
  • 98.23 (n)
dog
(Canis familiaris)
Mammalia VPS37B 33
  • 87.72 (n)
cow
(Bos Taurus)
Mammalia VPS37B 33
  • 86.67 (n)
rat
(Rattus norvegicus)
Mammalia Vps37b 33
  • 84.56 (n)
mouse
(Mus musculus)
Mammalia Vps37b 33 16 34
  • 83.27 (n)
oppossum
(Monodelphis domestica)
Mammalia VPS37B 34
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia VPS37B 34
  • 66 (a)
OneToOne
chicken
(Gallus gallus)
Aves VPS37B 33 34
  • 74.03 (n)
lizard
(Anolis carolinensis)
Reptilia VPS37B 34
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia vps37b 33
  • 64.26 (n)
MGC75912 33
African clawed frog
(Xenopus laevis)
Amphibia flj12750-prov 33
zebrafish
(Danio rerio)
Actinopterygii zgc:114173 33
  • 60.4 (n)
vps37b 34
  • 52 (a)
OneToMany
VPS37B (1 of 2) 34
  • 51 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003731 33
  • 48.88 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG1115 33 34
  • 46.96 (n)
worm
(Caenorhabditis elegans)
Secernentea vps-37 34
  • 25 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10674 34
  • 31 (a)
OneToMany
Species where no ortholog for VPS37B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for VPS37B Gene

ENSEMBL:
Gene Tree for VPS37B (if available)
TreeFam:
Gene Tree for VPS37B (if available)

Paralogs for VPS37B Gene

Paralogs for VPS37B Gene

(3) SIMAP similar genes for VPS37B Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with VPS37B: view

Variants for VPS37B Gene

Sequence variations from dbSNP and Humsavar for VPS37B Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000037591 -- 122,881,894(-) C/T genic_upstream_transcript_variant, intron_variant
rs1000090174 -- 122,874,683(-) T/C 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant
rs1000119167 -- 122,871,930(-) G/A 5_prime_UTR_variant, intron_variant
rs1000163742 -- 122,875,029(-) T/G genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000344487 -- 122,867,910(-) G/A genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for VPS37B Gene

Variant ID Type Subtype PubMed ID
nsv517200 CNV loss 19592680
nsv7239 OTHER inversion 18451855
nsv952498 CNV deletion 24416366

Variation tolerance for VPS37B Gene

Residual Variation Intolerance Score: 72.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.93; 19.36% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for VPS37B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
VPS37B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VPS37B Gene

Disorders for VPS37B Gene

Additional Disease Information for VPS37B

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for VPS37B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for VPS37B Gene

Publications for VPS37B Gene

  1. The human endosomal sorting complex required for transport (ESCRT-I) and its role in HIV-1 budding. (PMID: 15218037) Stuchell MD … Sundquist WI (The Journal of biological chemistry 2004) 2 3 4 58
  2. The UBAP1 subunit of ESCRT-I interacts with ubiquitin via a SOUBA domain. (PMID: 22405001) Agromayor M … Williams RL (Structure (London, England : 1993) 2012) 3 4 58
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  4. Biochemical analyses of human IST1 and its function in cytokinesis. (PMID: 19129479) Bajorek M … Sundquist WI (Molecular biology of the cell 2009) 3 4 58
  5. Human ESCRT and ALIX proteins interact with proteins of the midbody and function in cytokinesis. (PMID: 17853893) Morita E … Sundquist WI (The EMBO journal 2007) 3 4 58

Products for VPS37B Gene

Sources for VPS37B Gene

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