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Aliases for VPS37B Gene

Aliases for VPS37B Gene

  • VPS37B, ESCRT-I Subunit 2 3
  • Vacuolar Protein Sorting 37 Homolog B (S. Cerevisiae) 2 5
  • ESCRT-I Complex Subunit VPS37B 3 4
  • HVps37B 3 4
  • Vacuolar Protein Sorting 37 Homolog B 3
  • Vacuolar Protein Sorting 37B (Yeast) 2
  • Vacuolar Protein Sorting 37B 3

External Ids for VPS37B Gene

Previous GeneCards Identifiers for VPS37B Gene

  • GC12M121875
  • GC12M123349
  • GC12M120309

Summaries for VPS37B Gene

GeneCards Summary for VPS37B Gene

VPS37B (VPS37B, ESCRT-I Subunit) is a Protein Coding gene. Among its related pathways are HIV Life Cycle and Infectious disease. GO annotations related to this gene include calcium-dependent protein binding. An important paralog of this gene is VPS37C.

UniProtKB/Swiss-Prot for VPS37B Gene

  • Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VPS37B Gene

Genomics for VPS37B Gene

Regulatory Elements for VPS37B Gene

Promoters for VPS37B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around VPS37B on UCSC Golden Path with GeneCards custom track

Genomic Location for VPS37B Gene

Chromosome:
12
Start:
122,865,328 bp from pter
End:
122,896,444 bp from pter
Size:
31,117 bases
Orientation:
Minus strand

Genomic View for VPS37B Gene

Genes around VPS37B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
VPS37B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for VPS37B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VPS37B Gene

Proteins for VPS37B Gene

  • Protein details for VPS37B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H9H4-VP37B_HUMAN
    Recommended name:
    Vacuolar protein sorting-associated protein 37B
    Protein Accession:
    Q9H9H4

    Protein attributes for VPS37B Gene

    Size:
    285 amino acids
    Molecular mass:
    31307 Da
    Quaternary structure:
    • Component of the ESCRT-I complex (endosomal sorting complex required for transport I) which consists of TSG101, VPS28, a VPS37 protein (VPS37A to -D) and MVB12A or MVB12B in a 1:1:1:1 stoechiometry. Interacts with TSG101, VPS28, MVB12A and MVB12B. Component of the ESCRT-I complex (endosomal sorting complex required for transport I) which consists of TSG101, VPS28, a VPS37 protein (VPS37A to -D) and UBAP1 in a 1:1:1:1 stoechiometry. Interacts with CEP55. Interacts with IST1.

neXtProt entry for VPS37B Gene

Proteomics data for VPS37B Gene at MOPED

Post-translational modifications for VPS37B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for VPS37B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for VPS37B Gene

Domains & Families for VPS37B Gene

Gene Families for VPS37B Gene

Protein Domains for VPS37B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for VPS37B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H9H4

UniProtKB/Swiss-Prot:

VP37B_HUMAN :
  • Contains 1 VPS37 C-terminal domain.
  • Belongs to the VPS37 family.
Domain:
  • Contains 1 VPS37 C-terminal domain.
Family:
  • Belongs to the VPS37 family.
genes like me logo Genes that share domains with VPS37B: view

Function for VPS37B Gene

Molecular function for VPS37B Gene

UniProtKB/Swiss-Prot Function:
Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.
genes like me logo Genes that share phenotypes with VPS37B: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for VPS37B Gene

Localization for VPS37B Gene

Subcellular locations from UniProtKB/Swiss-Prot for VPS37B Gene

Late endosome membrane; Peripheral membrane protein. Note=Recruited to the endosomal membrane in a VPS4A-dependent fashion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for VPS37B Gene COMPARTMENTS Subcellular localization image for VPS37B gene
Compartment Confidence
endosome 5
extracellular 5
plasma membrane 5
cytosol 2
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for VPS37B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000813 ESCRT I complex TAS 20588296
GO:0010008 endosome membrane TAS --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with VPS37B: view

Pathways & Interactions for VPS37B Gene

genes like me logo Genes that share pathways with VPS37B: view

Pathways by source for VPS37B Gene

1 KEGG pathway for VPS37B Gene

Gene Ontology (GO) - Biological Process for VPS37B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006914 autophagy TAS 20588296
GO:0016032 viral process TAS --
GO:0016197 endosomal transport TAS --
GO:0019068 virion assembly TAS --
GO:0036258 multivesicular body assembly TAS 20588296
genes like me logo Genes that share ontologies with VPS37B: view

No data available for SIGNOR curated interactions for VPS37B Gene

Drugs & Compounds for VPS37B Gene

No Compound Related Data Available

Transcripts for VPS37B Gene

Unigene Clusters for VPS37B Gene

Vacuolar protein sorting 37 homolog B (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for VPS37B Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b
SP1: - -
SP2: -
SP3:

Relevant External Links for VPS37B Gene

GeneLoc Exon Structure for
VPS37B
ECgene alternative splicing isoforms for
VPS37B

Expression for VPS37B Gene

mRNA expression in normal human tissues for VPS37B Gene

mRNA differential expression in normal tissues according to GTEx for VPS37B Gene

This gene is overexpressed in Whole Blood (x4.5).

Protein differential expression in normal tissues from HIPED for VPS37B Gene

This gene is overexpressed in Breast (17.9), Urine (9.0), and Peripheral blood mononuclear cells (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for VPS37B Gene



SOURCE GeneReport for Unigene cluster for VPS37B Gene Hs.507162

mRNA Expression by UniProt/SwissProt for VPS37B Gene

Q9H9H4-VP37B_HUMAN
Tissue specificity: Widely expressed. Expressed in macrophages and lymphocytes.
genes like me logo Genes that share expression patterns with VPS37B: view

Protein tissue co-expression partners for VPS37B Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for VPS37B Gene

Orthologs for VPS37B Gene

This gene was present in the common ancestor of animals.

Orthologs for VPS37B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia VPS37B 35
  • 86.67 (n)
  • 92.28 (a)
dog
(Canis familiaris)
Mammalia VPS37B 35
  • 87.72 (n)
  • 90.53 (a)
mouse
(Mus musculus)
Mammalia Vps37b 35
  • 83.27 (n)
  • 83.86 (a)
Vps37b 16
Vps37b 36
  • 84 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia VPS37B 35
  • 98.23 (n)
  • 98.1 (a)
rat
(Rattus norvegicus)
Mammalia Vps37b 35
  • 84.56 (n)
  • 84.56 (a)
oppossum
(Monodelphis domestica)
Mammalia VPS37B 36
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia VPS37B 36
  • 66 (a)
OneToOne
chicken
(Gallus gallus)
Aves VPS37B 35
  • 74.03 (n)
  • 75.1 (a)
VPS37B 36
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia VPS37B 36
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC75912 35
vps37b 35
  • 64.26 (n)
  • 62.55 (a)
African clawed frog
(Xenopus laevis)
Amphibia flj12750-prov 35
zebrafish
(Danio rerio)
Actinopterygii zgc:114173 35
  • 60.4 (n)
  • 60.61 (a)
vps37b 36
  • 52 (a)
OneToMany
VPS37B (1 of 2) 36
  • 51 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003731 35
  • 48.88 (n)
  • 36.52 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG1115 35
  • 46.96 (n)
  • 34.59 (a)
CG1115 36
  • 32 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea vps-37 36
  • 25 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10674 36
  • 31 (a)
OneToMany
Species with no ortholog for VPS37B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for VPS37B Gene

ENSEMBL:
Gene Tree for VPS37B (if available)
TreeFam:
Gene Tree for VPS37B (if available)

Paralogs for VPS37B Gene

Paralogs for VPS37B Gene

(3) SIMAP similar genes for VPS37B Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with VPS37B: view

Variants for VPS37B Gene

Sequence variations from dbSNP and Humsavar for VPS37B Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1026395 -- 122,893,274(+) actaa(C/T)aggca intron-variant
rs1037593 -- 122,884,582(+) AGTGT(A/G/T)GGAGC intron-variant
rs2168279 -- 122,898,172(+) caggc(A/G)tgagc upstream-variant-2KB
rs2343107 -- 122,891,872(-) GACAG(A/G)TTGTT intron-variant
rs2277345 -- 122,868,289(+) CACCC(C/T)GCTGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for VPS37B Gene

Variant ID Type Subtype PubMed ID
nsv899571 CNV Loss 21882294
dgv1497n71 CNV Loss 21882294
nsv517200 CNV Loss 19592680
dgv1498n71 CNV Loss 21882294
nsv7239 OTHER Inversion 18451855

Variation tolerance for VPS37B Gene

Residual Variation Intolerance Score: 72.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.93; 19.36% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for VPS37B Gene

HapMap Linkage Disequilibrium report
VPS37B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VPS37B Gene

Disorders for VPS37B Gene

Relevant External Links for VPS37B

Genetic Association Database (GAD)
VPS37B
Human Genome Epidemiology (HuGE) Navigator
VPS37B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
VPS37B

No disorders were found for VPS37B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for VPS37B Gene

Publications for VPS37B Gene

  1. The human endosomal sorting complex required for transport (ESCRT-I) and its role in HIV-1 budding. (PMID: 15218037) Stuchell M.D. … Sundquist W.I. (J. Biol. Chem. 2004) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  4. The molecular basis for selective assembly of the UBAP1-containing endosome-specific ESCRT-I complex. (PMID: 24284069) Wunderley L. … Woodman P. (J. Cell. Sci. 2014) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for VPS37B Gene

Sources for VPS37B Gene

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