VPS37B Gene
protein-coding GIFtS: 50
GCID: GC12M123349
|
|
vacuolar protein sorting 37 homolog B (S. cerevisiae)(Previous name: vacuolar protein sorting 37B (yeast) )
| |
Aliases
for VPS37B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Vacuolar Protein Sorting 37 Homolog B (S. Cerevisiae)1 2 | | Vacuolar Protein Sorting 37B (Yeast)1 | | ESCRT-I Complex Subunit VPS37B2 3 | | Vacuolar Protein Sorting 37B2 | | HVps37B1 | | Vacuolar Protein Sorting-Associated Protein 37B2 | | FLJ127501 | | |
Export aliases for VPS37B gene to outside databasesPrevious GC identifers: GC12M121875 GC12M120309 |
Summaries
for VPS37B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: VP37B_HUMAN, Q9H9H4Function: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting ofendocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation
|
Genomic Views
for VPS37B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000012.11 NC_018923.1 NT_009755.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the VPS37B gene promoter:
RP58 AML1a POU2F1 Tal-1 deltaCREB POU2F1a E47
Other transcription factors
Search SABiosciences Chromatin IP Primers for VPS37B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat VPS37B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 12q24.31 Ensembl cytogenetic band: 12q24.31 HGNC cytogenetic band: 12q24.31VPS37B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12M123349: view genomic region
(about GC identifiers)
Start:
|
123,349,875 bp from pter |
End:
|
123,380,991 bp from pter |
Size:
|
31,117 bases |
Orientation:
|
minus strand |
|
Proteins
for VPS37B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: VP37B_HUMAN, Q9H9H4 (See
protein sequence)Recommended Name: Vacuolar protein sorting-associated protein 37B Size: 285 amino acids; 31307 Da
Subunit: Component of the ESCRT-I complex (endosomal sorting complex required for transport I) which consists ofTSG101, VPS28, a VPS37 protein (VPS37A to -D) and MVB12A or MVB12B in a 1:1:1:1 stoechiometry. Interacts with TSG101,VPS28, MVB12A and MVB12B. Interacts with CEP55. Interacts with IST1
Subcellular location: Late endosome membrane; Peripheral membrane protein. Note=Recruited to the endosomal membrane ina VPS4A-dependent fashionExplore the universe of human proteins at neXtProt for VPS37B: NX_Q9H9H4
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9H9H4
VPS37B Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_078943.1
ENSEMBL proteins: ENSP00000267202 ENSP00000446075 ENSP00000360294 Reactome Protein details: Q9H9H4
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
VPS37B for ontologies About GeneDecksing
VPS37B Antibody Products:
Assay Products for VPS37B: |
Protein
Domains /
Families
for VPS37B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
VPS37B for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9H9H4ProtoNet protein and cluster: Q9H9H4 UniProtKB/Swiss-Prot: VP37B_HUMAN, Q9H9H4Similarity: Belongs to the VPS37 familySimilarity: Contains 1 VPS37 C-terminal domain |
Function
for VPS37B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: VP37B_HUMAN, Q9H9H4Function: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting ofendocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for VPS37B (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for VPS37B
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VPS37B |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table
VPS37B for ontologies About GeneDecksing
|
Pathways & Interactions
for VPS37B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Signal Transduction | | | 2 | Late Phase of HIV Life Cycle | | | 3 | HIV Infection | | | 4 | Disease | | | 5 | Membrane Trafficking | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5/9 
Reactome Pathways for VPS37B (see all 9)
1 
Kegg Pathway (Kegg details for VPS37B):
VPS37B for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for VPS37B
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/28 Interacting proteins for VPS37B (Q9H9H42, 3 ENSP000002672024) via UniProtKB, MINT, STRING, and/or I2D (see all 28)About this table
Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table
VPS37B for ontologies About GeneDecksing
|
Drugs & Compounds
for VPS37B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for VPS37B
Search CenterWatch for drugs/clinical trials and news about VPS37B / VP37B
|
Transcripts
for VPS37B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for VPS37B gene: NM_024667.2 Unigene Cluster for VPS37B: Vacuolar protein sorting 37 homolog B (S. cerevisiae) Hs.507162 [show with all ESTs]Unigene Representative Sequence: BX6409114 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000267202(uc001udl.3) ENST00000535765 ENST00000371248 ENST00000543590
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for VPS37B (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for VPS37B
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: VPS37B (NM_024667) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for VPS37B | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VPS37B |
Additional cDNA sequence: AK022812.1 AK123249.1 BC005882.2 BX640911.1 10 DOTS entries: DT.80102057 DT.95117124 DT.100778084 DT.100667108 DT.121205226 DT.95275676 DT.95275678 DT.97763939 DT.121205197 DT.91744672 24/277 AceView cDNA sequences (see all 277): BM702538 BF941034 BM794759 BM741731 AI869848 BQ576026 BM665251 CD672715 BM697766 BM770579 BU736048 BM829498 AI685507 BM553082 BU155942 BU687477 BM552295 AA280283 AI536875 BU629695 BM794318 BI966702 AU279502 AI421718
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for VPS37B About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b |
|---|
|
| SP1: | | | - | | | | - | | | | | | | | |
| SP2: | | | | | | | - | | | | | | | | |
| SP3: | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for VPS37B
|
Expression
for VPS37B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| VPS37B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See VPS37B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for VPS37B
SOURCE GeneReport for Unigene cluster: Hs.507162
UniProtKB/Swiss-Prot: VP37B_HUMAN, Q9H9H4Tissue specificity: Widely expressed. Expressed in macrophages and lymphocytes
SABiosciences Custom PCR Arrays for VPS37B
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for VPS37B
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat VPS37B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat VPS37B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat VPS37B | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VPS37B |
Orthologs
for VPS37B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for VPS37B gene from 6/21 species (see all 21) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
VPS37B1 |
vacuolar protein sorting 37 homolog B (S. cerevisiae) |
73.9(n)
75(a) |
|
416835 XM_415126.3 XP_415126.1 |
lizard
(Anolis carolinensis) |
Reptilia |
VPS37B6 |
-- |
72(a) |
1 ↔ 1 |
LGb(2058139-2069277) |
African clawed frog
(Xenopus laevis) |
Amphibia |
flj12750-prov2 |
hypothetical protein MGC53304 |
76.26(n) |
|
BC042220.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
si:dkey-21k4.41 |
si:dkey-21k4.4 |
57.64(n)
56.68(a) |
|
559483 NM_001099996.1 NP_001093466.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG11151 |
CG1115 |
46.56(n)
34.54(a) |
|
40624 NM_141261.3 NP_649518.1 |
worm
(Caenorhabditis elegans) |
Secernentea |
vps-371 |
Protein VPS-37 |
39.89(n)
28.19(a) |
|
178944 NM_072073.2 NP_504474.1 |
ENSEMBL Gene Tree for VPS37B (if available)
TreeFam Gene Tree for VPS37B (if available) |
Paralogs
for VPS37B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for VPS37B gene
- VPS37C2 VPS37D2 VPS37A2
3 SIMAP similar genes for VPS37B using alignment to 3 protein entries: VP37B_HUMAN (see all proteins):VPS37C VPS37A VPS37D
VPS37B for paralogs About GeneDecksing
|
Genomic Variants
for VPS37B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 12 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for VPS37B (123349875 - 123380991 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 7 variations for VPS37B
6 CNVs: 48969 48968 48970 48972 48973 48971
1 Inversion: 37133 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing VPS37B |
|
Disorders
/ Diseases
for VPS37B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
VPS37B for disorders About GeneDecksing
OMIM gene information: 610037
OMIM disorders: --
1  disease for VPS37B: About MalaCardswilliams-beuren syndrome
Human Genome Epidemiology (HuGE) Navigator: VPS37B (1 document)
Export disorders for VPS37B gene to outside databases
|
Publications
for VPS37B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for VPS37B gene, integrated from 9 sources (see all 20):
(articles sorted by number of sources associating them with VPS37B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The human endosomal sorting complex required for transport (ESCRT-I) and its role in HIV-1 budding. (PubMed id 15218037)1, 2, 3 Stuchell M.D....Sundquist W.I. (2004)
- Biochemical analyses of human IST1 and its function in cytokinesis. (PubMed id 19129479)1, 2 Bajorek M....Sundquist W.I. (2009)
- Human ESCRT and ALIX proteins interact with proteins of the midbody and function in cytokinesis. (PubMed id 17853893)1, 2 Morita E....Sundquist W.I. (2007)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- The UBAP1 subunit of ESCRT-I interacts with ubiquitin via a SOUBA domain. (PubMed id 22405001)1 Agromayor M....Williams R.L. (2012)
- In vitro reconstitution of the ordered assembly of the endosomal sorting complex required for transport at membrane-bound HIV-1 Gag cl usters. (PubMed id 23027949)1 Carlson L.A. and Hurley J.H. (2012)
- Essential and supporting host cell factors for HIV-1 b udding. (PubMed id 22004035)1 Dordor A....Weissenhorn W. (2011)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
|
External Searches for VPS37B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing VPS37B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing VPS37B gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing VPS37B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for VPS37B | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for VPS37B gene:
Search GeneIP for patents involving VPS37B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for VPS37B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| |
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| |  |  |  |  | | | | |
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 |
 | | | VPS37B Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VPS37B |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VPS37B |
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