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Aliases for VPS37B Gene

Aliases for VPS37B Gene

  • Vacuolar Protein Sorting 37 Homolog B (S. Cerevisiae) 2 3
  • ESCRT-I Complex Subunit VPS37B 3 4
  • HVps37B 3 4
  • Vacuolar Protein Sorting-Associated Protein 37B 3
  • Vacuolar Protein Sorting 37B (Yeast) 2
  • Vacuolar Protein Sorting 37B 3

External Ids for VPS37B Gene

Previous GeneCards Identifiers for VPS37B Gene

  • GC12M121875
  • GC12M123349
  • GC12M120309

Summaries for VPS37B Gene

GeneCards Summary for VPS37B Gene

VPS37B (Vacuolar Protein Sorting 37 Homolog B (S. Cerevisiae)) is a Protein Coding gene. Among its related pathways are Disease and Endocytosis. An important paralog of this gene is VPS37C.

UniProtKB/Swiss-Prot for VPS37B Gene

  • Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VPS37B Gene

Genomics for VPS37B Gene

Regulatory Elements for VPS37B Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for VPS37B Gene

Start:
122,865,328 bp from pter
End:
122,896,444 bp from pter
Size:
31,117 bases
Orientation:
Minus strand

Genomic View for VPS37B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for VPS37B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VPS37B Gene

Proteins for VPS37B Gene

  • Protein details for VPS37B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H9H4-VP37B_HUMAN
    Recommended name:
    Vacuolar protein sorting-associated protein 37B
    Protein Accession:
    Q9H9H4
    Secondary Accessions:

    Protein attributes for VPS37B Gene

    Size:
    285 amino acids
    Molecular mass:
    31307 Da
    Quaternary structure:
    • Component of the ESCRT-I complex (endosomal sorting complex required for transport I) which consists of TSG101, VPS28, a VPS37 protein (VPS37A to -D) and MVB12A or MVB12B in a 1:1:1:1 stoechiometry. Interacts with TSG101, VPS28, MVB12A and MVB12B. Component of the ESCRT-I complex (endosomal sorting complex required for transport I) which consists of TSG101, VPS28, a VPS37 protein (VPS37A to -D) and UBAP1 in a 1:1:1:1 stoechiometry. Interacts with CEP55. Interacts with IST1.

neXtProt entry for VPS37B Gene

Proteomics data for VPS37B Gene at MOPED

Post-translational modifications for VPS37B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for VPS37B Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for VPS37B Gene

Domains for VPS37B Gene

Protein Domains for VPS37B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for VPS37B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H9H4

UniProtKB/Swiss-Prot:

VP37B_HUMAN :
  • Q9H9H4
Domain:
  • Contains 1 VPS37 C-terminal domain.
Family:
  • Belongs to the VPS37 family.
genes like me logo Genes that share domains with VPS37B: view

No data available for Gene Families for VPS37B Gene

Function for VPS37B Gene

Molecular function for VPS37B Gene

UniProtKB/Swiss-Prot Function: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.

Gene Ontology (GO) - Molecular Function for VPS37B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15218037
GO:0048306 calcium-dependent protein binding IPI 23924735
genes like me logo Genes that share ontologies with VPS37B: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for VPS37B

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for VPS37B Gene

Localization for VPS37B Gene

Subcellular locations from UniProtKB/Swiss-Prot for VPS37B Gene

Late endosome membrane; Peripheral membrane protein. Note=Recruited to the endosomal membrane in a VPS4A-dependent fashion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for VPS37B Gene COMPARTMENTS Subcellular localization image for VPS37B gene
Compartment Confidence
endosome 5
cytosol 2
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for VPS37B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000813 ESCRT I complex IDA 18005716
GO:0005737 cytoplasm IDA 15218037
GO:0005768 endosome IDA 17940959
GO:0005886 plasma membrane IDA 17940959
GO:0010008 endosome membrane TAS --
genes like me logo Genes that share ontologies with VPS37B: view

Pathways for VPS37B Gene

genes like me logo Genes that share pathways with VPS37B: view

Pathways by source for VPS37B Gene

1 KEGG pathway for VPS37B Gene

Gene Ontology (GO) - Biological Process for VPS37B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015031 protein transport IEA --
GO:0016032 viral process TAS --
GO:0016197 endosomal transport TAS --
GO:0019058 viral life cycle TAS --
GO:0019068 virion assembly TAS --
genes like me logo Genes that share ontologies with VPS37B: view

Transcripts for VPS37B Gene

Unigene Clusters for VPS37B Gene

Vacuolar protein sorting 37 homolog B (S. cerevisiae):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for VPS37B

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for VPS37B Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b
SP1: - -
SP2: -
SP3:

Relevant External Links for VPS37B Gene

GeneLoc Exon Structure for
VPS37B
ECgene alternative splicing isoforms for
VPS37B

Expression for VPS37B Gene

mRNA expression in normal human tissues for VPS37B Gene

mRNA differential expression in normal tissues according to GTEx for VPS37B Gene

This gene is overexpressed in Whole Blood (4.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for VPS37B Gene

SOURCE GeneReport for Unigene cluster for VPS37B Gene Hs.507162

mRNA Expression by UniProt/SwissProt for VPS37B Gene

Q9H9H4-VP37B_HUMAN
Tissue specificity: Widely expressed. Expressed in macrophages and lymphocytes.
genes like me logo Genes that share expressions with VPS37B: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for VPS37B Gene

Orthologs for VPS37B Gene

This gene was present in the common ancestor of animals.

Orthologs for VPS37B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia VPS37B 35
  • 98.23 (n)
  • 98.1 (a)
cow
(Bos Taurus)
Mammalia VPS37B 35
  • 86.67 (n)
  • 92.28 (a)
dog
(Canis familiaris)
Mammalia VPS37B 35
  • 87.72 (n)
  • 90.53 (a)
mouse
(Mus musculus)
Mammalia Vps37b 35
  • 83.27 (n)
  • 83.86 (a)
Vps37b 16
Vps37b 36
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia VPS37B 36
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia VPS37B 36
  • 66 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Vps37b 35
  • 84.56 (n)
  • 84.56 (a)
chicken
(Gallus gallus)
Aves VPS37B 35
  • 74.03 (n)
  • 75.1 (a)
VPS37B 36
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia VPS37B 36
  • 71 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia flj12750-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC75912 35
vps37b 35
  • 64.26 (n)
  • 62.55 (a)
zebrafish
(Danio rerio)
Actinopterygii vps37b 36
  • 52 (a)
OneToMany
VPS37B (1 of 2) 36
  • 51 (a)
OneToMany
zgc:114173 35
  • 60.4 (n)
  • 60.61 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003731 35
  • 48.88 (n)
  • 36.52 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG1115 35
  • 46.96 (n)
  • 34.59 (a)
CG1115 36
  • 32 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea vps-37 36
  • 25 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10674 36
  • 31 (a)
OneToMany
Species with no ortholog for VPS37B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for VPS37B Gene

ENSEMBL:
Gene Tree for VPS37B (if available)
TreeFam:
Gene Tree for VPS37B (if available)

Paralogs for VPS37B Gene

Paralogs for VPS37B Gene

Selected SIMAP similar genes for VPS37B Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with VPS37B: view

Variants for VPS37B Gene

Sequence variations from dbSNP and Humsavar for VPS37B Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs12255 -- 122,865,657(+) ATGTA(C/T)GGTCA utr-variant-3-prime
rs1026395 -- 122,893,274(+) actaa(C/T)aggca intron-variant
rs1037593 -- 122,884,582(+) AGTGT(A/G)GGAGC intron-variant
rs1050280 -- 122,865,699(-) GGGGT(C/T)TGGGC utr-variant-3-prime
rs1983098 -- 122,898,094(-) taaca(C/T)ggtga upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for VPS37B Gene

Variant ID Type Subtype PubMed ID
nsv899571 CNV Loss 21882294
dgv1497n71 CNV Loss 21882294
nsv517200 CNV Loss 19592680
dgv1498n71 CNV Loss 21882294
nsv7239 OTHER Inversion 18451855

Relevant External Links for VPS37B Gene

HapMap Linkage Disequilibrium report
VPS37B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VPS37B Gene

Disorders for VPS37B Gene

Relevant External Links for VPS37B

Genetic Association Database (GAD)
VPS37B
Human Genome Epidemiology (HuGE) Navigator
VPS37B
genes like me logo Genes that share disorders with VPS37B: view

No data available for UniProtKB/Swiss-Prot for VPS37B Gene

Publications for VPS37B Gene

  1. The human endosomal sorting complex required for transport (ESCRT-I) and its role in HIV-1 budding. (PMID: 15218037) Stuchell M.D. … Sundquist W.I. (J. Biol. Chem. 2004) 2 3 4
  2. Human ESCRT and ALIX proteins interact with proteins of the midbody and function in cytokinesis. (PMID: 17853893) Morita E. … Sundquist W.I. (EMBO J. 2007) 3 4
  3. Identification of human MVB12 proteins as ESCRT-I subunits that function in HIV budding. (PMID: 18005716) Morita E. … Sundquist W.I. (Cell Host Microbe 2007) 3 4
  4. The UBAP1 subunit of ESCRT-I interacts with ubiquitin via a SOUBA domain. (PMID: 22405001) Agromayor M. … Williams R.L. (Structure 2012) 3 4
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48

Products for VPS37B Gene

Sources for VPS37B Gene

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