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Aliases for VPS37B Gene

Aliases for VPS37B Gene

  • VPS37B, ESCRT-I Subunit 2 3 5
  • ESCRT-I Complex Subunit VPS37B 3 4
  • HVps37B 3 4
  • Vacuolar Protein Sorting 37 Homolog B (S. Cerevisiae) 2
  • Vacuolar Protein Sorting-Associated Protein 37B 3
  • Vacuolar Protein Sorting 37 Homolog B 3
  • Vacuolar Protein Sorting 37B (Yeast) 2
  • Vacuolar Protein Sorting 37B 3

External Ids for VPS37B Gene

Previous GeneCards Identifiers for VPS37B Gene

  • GC12M121875
  • GC12M123349
  • GC12M120309

Summaries for VPS37B Gene

GeneCards Summary for VPS37B Gene

VPS37B (VPS37B, ESCRT-I Subunit) is a Protein Coding gene. Among its related pathways are HIV Life Cycle and Budding and maturation of HIV virion. GO annotations related to this gene include calcium-dependent protein binding. An important paralog of this gene is VPS37C.

UniProtKB/Swiss-Prot for VPS37B Gene

  • Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.

Additional gene information for VPS37B Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VPS37B Gene

Genomics for VPS37B Gene

Regulatory Elements for VPS37B Gene

Enhancers for VPS37B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12H122866 1.4 FANTOM5 ENCODE dbSUPER 31.9 +28.7 28675 2 FOXA2 RB1 ARID4B DMAP1 RAD21 RARA YY1 SCRT2 ZNF143 CREM VPS37B HIP1R CCDC62 PITPNM2 B3GNT4 PIR39782 PIR41686 GC12M122867
GH12H122879 1.7 FANTOM5 Ensembl ENCODE dbSUPER 23.3 +13.9 13886 6 ZSCAN4 INSM2 FEZF1 ZNF2 RAD21 ZNF366 ZNF391 RUNX3 ZNF654 ZNF362 VPS37B OGFOD2 ABCB9 B3GNT4 ENSG00000280138 PIR39782
GH12H122834 1.6 Ensembl ENCODE dbSUPER 18.1 +57.7 57698 9 PKNOX1 FOXA2 ARID4B SIN3A YBX1 FEZF1 ZNF2 YY1 FOS SP3 VPS37B ATP6V0A2 HIP1R ABCB9 B3GNT4 PIR62748
GH12H122885 1.4 ENCODE dbSUPER 19.7 +4.8 4836 11 HDGF PKNOX1 FOXA2 ARNT SIN3A ZNF2 YY1 ZNF766 CBX5 ZNF143 RSRC2 ZCCHC8 DDX55 EIF2B1 ATP6V0A2 KNTC1 VPS37B OGFOD2 LOC101927415 TCTN2
GH12H122870 1.1 ENCODE dbSUPER 24.4 +24.2 24197 4 HDGF SIN3A BATF ETS1 SCRT2 ATF7 ETV6 RUNX3 CREM IKZF2 VPS37B HIP1R CCDC62 B3GNT4 PIR39782 ENSG00000280138
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around VPS37B on UCSC Golden Path with GeneCards custom track

Promoters for VPS37B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000058661 644 1601 HDGF PKNOX1 ARNT SIN3A ZNF2 ZNF766 CBX5 ZNF143 ZNF207 FOS

Genomic Location for VPS37B Gene

Chromosome:
12
Start:
122,865,328 bp from pter
End:
122,896,444 bp from pter
Size:
31,117 bases
Orientation:
Minus strand

Genomic View for VPS37B Gene

Genes around VPS37B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
VPS37B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for VPS37B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VPS37B Gene

Proteins for VPS37B Gene

  • Protein details for VPS37B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H9H4-VP37B_HUMAN
    Recommended name:
    Vacuolar protein sorting-associated protein 37B
    Protein Accession:
    Q9H9H4

    Protein attributes for VPS37B Gene

    Size:
    285 amino acids
    Molecular mass:
    31307 Da
    Quaternary structure:
    • Component of the ESCRT-I complex (endosomal sorting complex required for transport I) which consists of TSG101, VPS28, a VPS37 protein (VPS37A to -D) and MVB12A or MVB12B in a 1:1:1:1 stoichiometry. Interacts with TSG101, VPS28, MVB12A and MVB12B. Component of the ESCRT-I complex (endosomal sorting complex required for transport I) which consists of TSG101, VPS28, a VPS37 protein (VPS37A to -D) and UBAP1 in a 1:1:1:1 stoichiometry. Interacts with CEP55. Interacts with IST1.

neXtProt entry for VPS37B Gene

Post-translational modifications for VPS37B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for VPS37B Gene

Domains & Families for VPS37B Gene

Gene Families for VPS37B Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for VPS37B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for VPS37B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H9H4

UniProtKB/Swiss-Prot:

VP37B_HUMAN :
  • Belongs to the VPS37 family.
Family:
  • Belongs to the VPS37 family.
genes like me logo Genes that share domains with VPS37B: view

Function for VPS37B Gene

Molecular function for VPS37B Gene

UniProtKB/Swiss-Prot Function:
Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.

Phenotypes From GWAS Catalog for VPS37B Gene

Gene Ontology (GO) - Molecular Function for VPS37B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15218037
GO:0048306 calcium-dependent protein binding IPI 23924735
genes like me logo Genes that share ontologies with VPS37B: view
genes like me logo Genes that share phenotypes with VPS37B: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for VPS37B
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for VPS37B Gene

Localization for VPS37B Gene

Subcellular locations from UniProtKB/Swiss-Prot for VPS37B Gene

Late endosome membrane; Peripheral membrane protein. Note=Recruited to the endosomal membrane in a VPS4A-dependent fashion.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for VPS37B gene
Compartment Confidence
plasma membrane 5
extracellular 5
endosome 5
nucleus 2
cytosol 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for VPS37B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000813 ESCRT I complex TAS 20588296
GO:0005737 cytoplasm IDA 15218037
GO:0005768 endosome IEA,IDA 17940959
GO:0005886 plasma membrane IDA 17940959
GO:0010008 endosome membrane TAS,IDA --
genes like me logo Genes that share ontologies with VPS37B: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for VPS37B Gene

Pathways & Interactions for VPS37B Gene

genes like me logo Genes that share pathways with VPS37B: view

Pathways by source for VPS37B Gene

Gene Ontology (GO) - Biological Process for VPS37B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0015031 protein transport IEA --
GO:0016197 endosomal transport TAS --
GO:0016236 macroautophagy TAS 20588296
GO:0019058 viral life cycle TAS --
genes like me logo Genes that share ontologies with VPS37B: view

No data available for SIGNOR curated interactions for VPS37B Gene

Drugs & Compounds for VPS37B Gene

No Compound Related Data Available

Transcripts for VPS37B Gene

Unigene Clusters for VPS37B Gene

Vacuolar protein sorting 37 homolog B (S. cerevisiae):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for VPS37B
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for VPS37B Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b
SP1: - -
SP2: -
SP3:

Relevant External Links for VPS37B Gene

GeneLoc Exon Structure for
VPS37B
ECgene alternative splicing isoforms for
VPS37B

Expression for VPS37B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for VPS37B Gene

mRNA differential expression in normal tissues according to GTEx for VPS37B Gene

This gene is overexpressed in Whole Blood (x4.5).

Protein differential expression in normal tissues from HIPED for VPS37B Gene

This gene is overexpressed in Breast (17.9), Urine (9.0), and Peripheral blood mononuclear cells (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for VPS37B Gene



Protein tissue co-expression partners for VPS37B Gene

NURSA nuclear receptor signaling pathways regulating expression of VPS37B Gene:

VPS37B

SOURCE GeneReport for Unigene cluster for VPS37B Gene:

Hs.507162

mRNA Expression by UniProt/SwissProt for VPS37B Gene:

Q9H9H4-VP37B_HUMAN
Tissue specificity: Widely expressed. Expressed in macrophages and lymphocytes.

Evidence on tissue expression from TISSUES for VPS37B Gene

  • Muscle(4.2)
  • Nervous system(3.5)
  • Gall bladder(2)
  • Intestine(2)
  • Lymph node(2)
  • Stomach(2)
genes like me logo Genes that share expression patterns with VPS37B: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for VPS37B Gene

Orthologs for VPS37B Gene

This gene was present in the common ancestor of animals.

Orthologs for VPS37B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia VPS37B 33
  • 98.23 (n)
dog
(Canis familiaris)
Mammalia VPS37B 33
  • 87.72 (n)
cow
(Bos Taurus)
Mammalia VPS37B 33
  • 86.67 (n)
rat
(Rattus norvegicus)
Mammalia Vps37b 33
  • 84.56 (n)
mouse
(Mus musculus)
Mammalia Vps37b 33 16 34
  • 83.27 (n)
oppossum
(Monodelphis domestica)
Mammalia VPS37B 34
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia VPS37B 34
  • 66 (a)
OneToOne
chicken
(Gallus gallus)
Aves VPS37B 33 34
  • 74.03 (n)
lizard
(Anolis carolinensis)
Reptilia VPS37B 34
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia vps37b 33
  • 64.26 (n)
MGC75912 33
African clawed frog
(Xenopus laevis)
Amphibia flj12750-prov 33
zebrafish
(Danio rerio)
Actinopterygii zgc:114173 33
  • 60.4 (n)
vps37b 34
  • 52 (a)
OneToMany
VPS37B (1 of 2) 34
  • 51 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003731 33
  • 48.88 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG1115 33 34
  • 46.96 (n)
worm
(Caenorhabditis elegans)
Secernentea vps-37 34
  • 25 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10674 34
  • 31 (a)
OneToMany
Species where no ortholog for VPS37B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for VPS37B Gene

ENSEMBL:
Gene Tree for VPS37B (if available)
TreeFam:
Gene Tree for VPS37B (if available)

Paralogs for VPS37B Gene

Paralogs for VPS37B Gene

(3) SIMAP similar genes for VPS37B Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with VPS37B: view

Variants for VPS37B Gene

Sequence variations from dbSNP and Humsavar for VPS37B Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000037591 -- 122,881,894(+) AGGTT(C/T)GACAA intron-variant
rs1000090174 -- 122,874,683(+) GTGGC(C/T)CACAC intron-variant, utr-variant-5-prime
rs1000119167 -- 122,871,930(+) CAGCC(A/G)CCGCC intron-variant, utr-variant-5-prime
rs1000163742 -- 122,875,029(+) TCCTT(G/T)GGGTA intron-variant, upstream-variant-2KB
rs1000344487 -- 122,867,910(+) AGCCC(A/G)CTGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for VPS37B Gene

Variant ID Type Subtype PubMed ID
nsv517200 CNV loss 19592680
nsv7239 OTHER inversion 18451855
nsv952498 CNV deletion 24416366

Variation tolerance for VPS37B Gene

Residual Variation Intolerance Score: 72.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.93; 19.36% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for VPS37B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
VPS37B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VPS37B Gene

Disorders for VPS37B Gene

Relevant External Links for VPS37B

Genetic Association Database (GAD)
VPS37B
Human Genome Epidemiology (HuGE) Navigator
VPS37B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
VPS37B

No disorders were found for VPS37B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for VPS37B Gene

Publications for VPS37B Gene

  1. The human endosomal sorting complex required for transport (ESCRT-I) and its role in HIV-1 budding. (PMID: 15218037) Stuchell MD … Sundquist WI (The Journal of biological chemistry 2004) 2 3 4 60
  2. The UBAP1 subunit of ESCRT-I interacts with ubiquitin via a SOUBA domain. (PMID: 22405001) Agromayor M … Williams RL (Structure (London, England : 1993) 2012) 3 4 60
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  4. Biochemical analyses of human IST1 and its function in cytokinesis. (PMID: 19129479) Bajorek M … Sundquist WI (Molecular biology of the cell 2009) 3 4 60
  5. Identification of human MVB12 proteins as ESCRT-I subunits that function in HIV budding. (PMID: 18005716) Morita E … Sundquist WI (Cell host & microbe 2007) 3 4 60

Products for VPS37B Gene

Sources for VPS37B Gene

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